G Liu

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. pmc Polymorphisms of inflammatory and metalloproteinase genes, Helicobacter pylori infection and the risk of oesophageal adenocarcinoma
    M Fruh
    Medical Oncology, Department of Medicine, Princess Margaret Hospital, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
    Br J Cancer 98:689-92. 2008
  2. pmc Association between UGT1A1*28 polymorphisms and clinical outcomes of irinotecan-based chemotherapies in colorectal cancer: a meta-analysis in Caucasians
    Xiang Liu
    Ontario Cancer Institute, Toronto, Ontario, Canada
    PLoS ONE 8:e58489. 2013
  3. pmc Addition of multiple rare SNPs to known common variants improves the association between disease and gene in the Genetic Analysis Workshop 17 data
    Jenna Sykes
    Department of Biostatistics, Princess Margaret Hospital, 610 University Avenue, Toronto, ON M5G 2M9, Canada
    BMC Proc 5:S97. 2011
  4. pmc A pathway-based association analysis model using common and rare variants
    Lu Cheng
    Department of Biostatistics, Princess Margaret Hospital, 610 University Ave, Toronto, ON M5G 2M9, Canada
    BMC Proc 5:S85. 2011
  5. ncbi request reprint Pharmacogenetic analysis of BR.21, a placebo-controlled randomized phase III clinical trial of erlotinib in advanced non-small cell lung cancer
    Geoffrey Liu
    Medical Oncology and Hematology, Department of Medicine, Princess Margaret Hospital University Health Network and University of Toronto, Toronto, Canada
    J Thorac Oncol 7:316-22. 2012
  6. ncbi request reprint XRCC1 and XPD polymorphisms and esophageal adenocarcinoma risk
    Geoffrey Liu
    Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Carcinogenesis 28:1254-8. 2007
  7. ncbi request reprint Epidermal growth factor receptor polymorphisms and clinical outcomes in non-small-cell lung cancer patients treated with gefitinib
    G Liu
    Department of Medicine, Harvard Medical School, Massachusetts General Hospital Cancer Center and Hematology Oncology Division, Massachusetts General Hospital, Boston, MA, USA
    Pharmacogenomics J 8:129-38. 2008
  8. ncbi request reprint Genetic polymorphisms of MDM2, cumulative cigarette smoking and nonsmall cell lung cancer risk
    Geoffrey Liu
    Applied Molecular Oncology Department of Medicine, Ontario Cancer Institute Princess Margaret Hospital, University of Toronto, Toronto, ON, Canada
    Int J Cancer 122:915-8. 2008
  9. pmc p53 Arg72Pro, MDM2 T309G and CCND1 G870A polymorphisms are not associated with susceptibility to esophageal adenocarcinoma
    G Liu
    Division of Medical Oncology and Hematology, Department of Medicine, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
    Dis Esophagus 23:36-9. 2010
  10. ncbi request reprint Differential association of the codon 72 p53 and GSTM1 polymorphisms on histological subtype of non-small cell lung carcinoma
    G Liu
    Department of Environmental Health, Occupational Health Program, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Res 61:8718-22. 2001

Research Grants

Collaborators

Detail Information

Publications84

  1. pmc Polymorphisms of inflammatory and metalloproteinase genes, Helicobacter pylori infection and the risk of oesophageal adenocarcinoma
    M Fruh
    Medical Oncology, Department of Medicine, Princess Margaret Hospital, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
    Br J Cancer 98:689-92. 2008
    ..In MMP2 wild-type individuals, HP was significantly protective of EA risk (adjusted odds ratio: 0.29; 95% confidence interval=0.1-0.7). Matrix metalloproteinases may modulate the EA-HP relationship...
  2. pmc Association between UGT1A1*28 polymorphisms and clinical outcomes of irinotecan-based chemotherapies in colorectal cancer: a meta-analysis in Caucasians
    Xiang Liu
    Ontario Cancer Institute, Toronto, Ontario, Canada
    PLoS ONE 8:e58489. 2013
    ..Published data on the association between UGT1A1*28 gene polymorphisms and clinical outcomes of IRI-based chemotherapy in CRC were inconsistent...
  3. pmc Addition of multiple rare SNPs to known common variants improves the association between disease and gene in the Genetic Analysis Workshop 17 data
    Jenna Sykes
    Department of Biostatistics, Princess Margaret Hospital, 610 University Avenue, Toronto, ON M5G 2M9, Canada
    BMC Proc 5:S97. 2011
    ..Adjusting for significant clinical parameters, several genes were found to have multiple rare variants that were significantly associated with disease outcome...
  4. pmc A pathway-based association analysis model using common and rare variants
    Lu Cheng
    Department of Biostatistics, Princess Margaret Hospital, 610 University Ave, Toronto, ON M5G 2M9, Canada
    BMC Proc 5:S85. 2011
    ..In this simulated example, we were able to identify several pathways that were potentially associated with the disease status and found that common variants showed stronger genetic effect than rare variants...
  5. ncbi request reprint Pharmacogenetic analysis of BR.21, a placebo-controlled randomized phase III clinical trial of erlotinib in advanced non-small cell lung cancer
    Geoffrey Liu
    Medical Oncology and Hematology, Department of Medicine, Princess Margaret Hospital University Health Network and University of Toronto, Toronto, Canada
    J Thorac Oncol 7:316-22. 2012
    ..Predictive and prognostic analyses of epidermal growth factor receptor (EGFR), ABCG2, and AKT1 genetic polymorphisms were performed...
  6. ncbi request reprint XRCC1 and XPD polymorphisms and esophageal adenocarcinoma risk
    Geoffrey Liu
    Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Carcinogenesis 28:1254-8. 2007
    ..No relationships were found for the XPD Asp312Asn polymorphism. We conclude that combined NER and BER pathways are important to the development of EA...
  7. ncbi request reprint Epidermal growth factor receptor polymorphisms and clinical outcomes in non-small-cell lung cancer patients treated with gefitinib
    G Liu
    Department of Medicine, Harvard Medical School, Massachusetts General Hospital Cancer Center and Hematology Oncology Division, Massachusetts General Hospital, Boston, MA, USA
    Pharmacogenomics J 8:129-38. 2008
    ..01) and a significantly higher risk of treatment-related rash/diarrhea (P=0.004, multivariate model). EGFR intron 1 and -216G/T polymorphisms influence clinical outcomes in gefitinib-treated non-small-cell lung cancer patients...
  8. ncbi request reprint Genetic polymorphisms of MDM2, cumulative cigarette smoking and nonsmall cell lung cancer risk
    Geoffrey Liu
    Applied Molecular Oncology Department of Medicine, Ontario Cancer Institute Princess Margaret Hospital, University of Toronto, Toronto, ON, Canada
    Int J Cancer 122:915-8. 2008
    ..63 (0.4-1.1), respectively, for never, mild (<30 pack-years), moderate (30-57 pack-years) and heavy smokers (>or=58 pack-years). In conclusion, a strong gene-smoking interaction was observed between the MDM2 SNP309 and NSCLC risk...
  9. pmc p53 Arg72Pro, MDM2 T309G and CCND1 G870A polymorphisms are not associated with susceptibility to esophageal adenocarcinoma
    G Liu
    Division of Medical Oncology and Hematology, Department of Medicine, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
    Dis Esophagus 23:36-9. 2010
    ..In contrast to the results of smaller published studies, no association between p53 Arg72Pro, MDM2 T309G, and CCND1 G870A SNPs and susceptibility to esophageal adenocarcinoma, age of onset, or stage of disease at diagnosis was detected...
  10. ncbi request reprint Differential association of the codon 72 p53 and GSTM1 polymorphisms on histological subtype of non-small cell lung carcinoma
    G Liu
    Department of Environmental Health, Occupational Health Program, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Res 61:8718-22. 2001
    ..1-2.8; case-only analysis) of having AC versus SCC if they also carried a p53 Pro allele. We conclude that different genotype combinations of p53 and GSTM1 increase the risk of developing specific histological subtypes of NSCLC...
  11. pmc Two novel BRM insertion promoter sequence variants are associated with loss of BRM expression and lung cancer risk
    G Liu
    Department of Medicine, Division of Medical Oncology and Hematology, Ontario Cancer Institute, Princess Margaret Hospital University Health Network, University of Toronto, Toronto, Ontario, Canada
    Oncogene 30:3295-304. 2011
    ..These polymorphisms thus have the potential to identify a sub-population of smokers at greater lung cancer risk, wherein this risk could be driven by an aberrant SWI/SNF chromatin-remodeling pathway...
  12. pmc Volumetric bone mineral density at the spine and hip in Chinese American and White women
    M D Walker
    Department of Medicine, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, PH8 West 864, New York, NY 10032, USA
    Osteoporos Int 23:2499-506. 2012
    ..Compared with White women, Chinese American women have greater cortical volumetric bone density (vBMD) at the hip, congruent with the results at the peripheral skeleton...
  13. ncbi request reprint The interaction between microsomal epoxide hydrolase polymorphisms and cumulative cigarette smoking in different histological subtypes of lung cancer
    W Zhou
    Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 10:461-6. 2001
    ....
  14. ncbi request reprint The SOD2 Val/Val genotype enhances the risk of nonsmall cell lung carcinoma by p53 and XRCC1 polymorphisms
    Geoffrey Liu
    Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer 101:2802-8. 2004
    ..p53 is a tumor suppressor gene, and X-ray cross-complementing group 1 (XRCC1) is involved in the base-excision repair of ROS-induced DNA damage...
  15. ncbi request reprint Polymorphisms in the DNA repair genes XRCC1 and ERCC2, smoking, and lung cancer risk
    Wei Zhou
    Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 12:359-65. 2003
    ..In conclusion, cumulative cigarette smoking plays an important role in altering the direction and magnitude of the associations between the XRCC1 and ERCC2 polymorphisms and lung cancer risk...
  16. doi request reprint Overview of molecular testing in non-small-cell lung cancer: mutational analysis, gene copy number, protein expression and other biomarkers of EGFR for the prediction of response to tyrosine kinase inhibitors
    T John
    University Health Network, Princess Margaret Hospital Site, Ontario Cancer Institute, University of Toronto, Toronto, Ontario, Canada
    Oncogene 28:S14-23. 2009
    ..Many techniques are available to assay for these biomarkers. In this review, we present the current weight of evidence for using these methods as biomarkers for anti-EGFR therapy in patients with NSCLC...
  17. pmc Polymorphisms of the NER pathway genes, ERCC1 and XPD are associated with esophageal adenocarcinoma risk
    Darren Tse
    Department of Applied Molecular Oncology, Ontario Cancer Institute, Princess Margaret Hospital, Toronto, ON, Canada
    Cancer Causes Control 19:1077-83. 2008
    ..Studies have focused on the nucleotide excision repair (NER) and base excision repair (BER) pathways. We investigated whether variant alleles in seven SNPs within these pathways increased the risk of esophageal adenocarcinoma...
  18. pmc A phase I study of the combination of ro4929097 and cediranib in patients with advanced solid tumours (PJC-004/NCI 8503)
    S Sahebjam
    Princess Margaret Hospital, Toronto, ON M5G 2M9, Canada
    Br J Cancer 109:943-9. 2013
    ....
  19. pmc Polymorphisms in GSTM1, GSTT1 and CYP1A1 and risk of pancreatic adenocarcinoma
    G Liu
    Centre for Research in Women s Health, Women s College Hospital, University of Toronto, Canada
    Br J Cancer 82:1646-9. 2000
    ..14), GSTT1 (AOR: 1.19) and CYP1A1 (AOR: 1.08) polymorphisms and pancreatic cancer susceptibility. Smoking and drinking status did not affect results. These polymorphisms do not appear to be important gene modifiers in pancreatic cancer...
  20. ncbi request reprint Matrix metalloproteinase-1 promoter polymorphism and lung cancer risk
    Li Su
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 14:567-70. 2005
    ..00-1.75; 1G/2G) and 1.23 (95% CI, 0.88-1.73; 2G/2G) in males, respectively. In conclusion, genotypes containing the 2G allele of the MMP-1 polymorphism are associated with higher risk of lung cancer in never-smokers and in males...
  21. pmc Interactions among genetic variants in apoptosis pathway genes, reflux symptoms, body mass index, and smoking indicate two distinct etiologic patterns of esophageal adenocarcinoma
    Rihong Zhai
    Department of Environmental Health, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    J Clin Oncol 28:2445-51. 2010
    ..However, how multiple factors jointly affect EA risk remains unclear...
  22. pmc Matrix metalloproteinase 1, 3 and 12 polymorphisms and esophageal adenocarcinoma risk and prognosis
    Penelope A Bradbury
    Medical Oncology and Hematology, Biostatistics, Princess Margaret Hospital and Department of Medicine, Dalla Lama School of Public Health and University of Toronto, Ontario, Canada
    Carcinogenesis 30:793-8. 2009
    ..MMP1, MMP3 and possibly MMP12 -82A/G polymorphisms and their haplotypes are associated with increased EA risk...
  23. ncbi request reprint XPD and XRCC1 genetic polymorphisms are prognostic factors in advanced non-small-cell lung cancer patients treated with platinum chemotherapy
    Sarada Gurubhagavatula
    Department of Medicine, Massachusetts General Hospital, Boston, MA USA
    J Clin Oncol 22:2594-601. 2004
    ..Genetic polymorphisms of DNA repair genes are associated with differential DNA repair activity and may explain interindividual differences in overall survival after therapy with platinum agents for non-small-cell lung cancer (NSCLC)...
  24. ncbi request reprint Gene-environment interaction for the ERCC2 polymorphisms and cumulative cigarette smoking exposure in lung cancer
    Wei Zhou
    Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Res 62:1377-81. 2002
    ..A stronger gene-smoking interaction was observed for the Asp312Asn polymorphism than for the Lys751Gln polymorphism. In conclusion, cumulative cigarette smoking modifies the associations between ERCC2 polymorphisms and lung cancer risk...
  25. doi request reprint Vascular endothelial growth factor genotypes, haplotypes, gender, and the risk of non-small cell lung cancer
    Rihong Zhai
    Department of Environmental Health, Princess Margaret Hospital Ontario Cancer Institute, University of Toronto, Toronto, Ontario, Canada
    Clin Cancer Res 14:612-7. 2008
    ..In this large case-control study, we investigated whether functional polymorphisms (-460C/T, +405C/G, +936C/T) in the VEGF gene are associated with the risk of non-small cell lung cancer (NSCLC)...
  26. pmc Genetic polymorphisms of VEGF, interactions with cigarette smoking exposure and esophageal adenocarcinoma risk
    Rihong Zhai
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Carcinogenesis 29:2330-4. 2008
    ..70; 95% CI, 1.04-2.73; P = 0.034). These results suggested that cigarette smoking modifies the association between VEGF polymorphisms and EA risk among Caucasians...
  27. pmc p53 Arg72Pro and MDM2 T309G polymorphisms, histology, and esophageal cancer prognosis
    David W Cescon
    Department of Medical Biophysics, Princess Margaret Hospital, University of Toronto, Canada
    Clin Cancer Res 15:3103-9. 2009
    ....
  28. ncbi request reprint Polymorphisms in ERCC1 and grade 3 or 4 toxicity in non-small cell lung cancer patients
    Rebecca Suk
    Massachusetts General Hospital and Harvard School of Public Health, Boston, MA 02115, USA
    Clin Cancer Res 11:1534-8. 2005
    ..Polymorphisms have been identified in the ERCC1 gene, the C8092A and codon 118 polymorphisms, which may lead to an altered capacity to regenerate damaged normal tissue and greater treatment-related toxicity...
  29. ncbi request reprint Counterpoint: the myeloperoxidase -463G-->a polymorphism does not decrease lung cancer susceptibility in Caucasians
    Li Lian Xu
    Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 11:1555-9. 2002
    ..These findings are in contrast with earlier studies suggesting a protective effect of carrying the variant A allele...
  30. ncbi request reprint MPO and SOD2 polymorphisms, gender, and the risk of non-small cell lung carcinoma
    Geoffrey Liu
    Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Lett 214:69-79. 2004
    ..For women carrying the MPO variant genotypes, the adjusted odds ratio of the SOD2 polymorphism (Val/Val vs. Ala/Ala) was 3.26 (95% CI, 1.55-6.83). No associations were found in men or in women carrying the MPO GG wildtype genotype...
  31. ncbi request reprint The G to C polymorphism at -174 of the interleukin-6 gene is rare in a Southern Chinese population
    R Zhai
    Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Pharmacogenetics 11:699-701. 2001
    ..Only one GC heterozygous and no CC homozygous variants were found. Our results suggest that the frequency of the C allele in this Chinese population is lower than in Caucasian and east Indian populations...
  32. ncbi request reprint Gene-smoking interaction associations for the ERCC1 polymorphisms in the risk of lung cancer
    Wei Zhou
    Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 14:491-6. 2005
    ..In conclusion, ERCC1 8092C > A polymorphism may modify the associations between cumulative cigarette smoking and lung cancer risk...
  33. pmc Cisplatin pharmacogenetics, DNA repair polymorphisms, and esophageal cancer outcomes
    Penelope A Bradbury
    Princess Margaret Hospital and University of Toronto, Toronto, Ontario, Canada
    Pharmacogenet Genomics 19:613-25. 2009
    ..We investigated the potential predictive significance of functional NER single nucleotide polymorphisms in esophageal cancer patients treated with (n = 262) or without (n = 108) cisplatin...
  34. ncbi request reprint MDM2 promoter polymorphism and pancreatic cancer risk and prognosis
    Kofi Asomaning
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Clin Cancer Res 14:4010-5. 2008
    ..We hypothesized that the G allele is also associated with increased risk and worse outcome in pancreatic cancer...
  35. pmc Apoptosis gene polymorphisms, age, smoking and the risk of non-small cell lung cancer
    Monica Ter-Minassian
    Department of Environmental Health, Harvard School of Public Health, Boston 02115, MA, USA
    Carcinogenesis 29:2147-52. 2008
    ..17). No interactions were observed for FAS -1377 G>A and BAT3 Ser625Pro polymorphisms. Our findings indicate that age and smoking may modify the association of the FASLG -844 and IL1B + 3954 SNPs with the risk of NSCLC...
  36. ncbi request reprint No association between the p21 codon 31 serine-arginine polymorphism and lung cancer risk
    Li Su
    Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 12:174-5. 2003
  37. ncbi request reprint Combinations of the variant genotypes of GSTP1, GSTM1, and p53 are associated with an increased lung cancer risk
    David P Miller
    Department of Environmental Heath, Occupational Health Program, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Cancer Res 62:2819-23. 2002
    ..03 (95% CI, 1.47-11.1); for the P1-p53 DV the AOR was 5.10 (95% CI, 1.42-18.30). Specific DVs of GSTM1, GSTP1, and p53 codon 72 are associated with a higher lung cancer risk. This susceptibility is highest among younger individuals...
  38. ncbi request reprint MDM2 polymorphism, survival, and histology in early-stage non-small-cell lung cancer
    Rebecca Suk Heist
    Massachusetts General Hospital, Boston, MA, USA
    J Clin Oncol 25:2243-7. 2007
    ..We hypothesized that the MDM2 G/G genotype may be associated with worse survival outcomes in lung cancer, especially in squamous cell cancers where p53 abnormalities are more common...
  39. pmc A functional epidermal growth factor (EGF) polymorphism, EGF serum levels, and esophageal adenocarcinoma risk and outcome
    Michael Lanuti
    Division of Thoracic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Clin Cancer Res 14:3216-22. 2008
    ..We hypothesized that the EGF A61G homozygous variant genotype (GG) is (a) both a risk and poor prognostic factor for EAC and (b) associated with higher EGF serum levels in individuals with gastroesophageal reflux disease (GERD)...
  40. ncbi request reprint Genetic polymorphisms in N-acetyltransferase-2 and microsomal epoxide hydrolase, cumulative cigarette smoking, and lung cancer
    Wei Zhou
    Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 11:15-21. 2002
    ..The joint effects of NAT2 and mEH polymorphisms are consistent with an independent, additive effect of these two genes, modified by smoking history...
  41. doi request reprint Role of mitochondrial hOGG1 and aconitase in oxidant-induced lung epithelial cell apoptosis
    V Panduri
    Department of Medicine, Northwestern University Feinberg School of Medicine and Jesse Brown VA Medical Center, 240 E Huron, McGaw M 330, Chicago, IL 60611, USA
    Free Radic Biol Med 47:750-9. 2009
    ....
  42. pmc Vascular endothelial growth factor polymorphisms and esophageal cancer prognosis
    Penelope A Bradbury
    Medical Oncology and Haematology, Department of Medicine, Princess Margaret Hospital, Ontario Cancer Institute, University of Toronto, Toronto, Ontario M5G 2M9, Canada
    Clin Cancer Res 15:4680-5. 2009
    ..Vascular endothelial growth factor (VEGF) promotes angiogenesis and vascular permeability. The VEGF gene is polymorphic. We investigated the prognostic significance of three VEGF single nucleotide polymorphisms (SNP) in esophageal cancer...
  43. doi request reprint Genetic variations in esophageal cancer risk and prognosis
    Winson Y Cheung
    Medical Oncology and Hematology, Medicine, Princess Margaret Hospital Ontario Cancer Institute, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada
    Gastroenterol Clin North Am 38:75-91, viii. 2009
    ..This review discusses the role of genetic polymorphisms and their association with esophageal cancer risk and prognosis. The article also highlights future directions in this new, emerging field of molecular epidemiology...
  44. ncbi request reprint Molecular epidemiology of non-small cell lung cancer
    Geoffrey Liu
    Harvard Medical School, Boston, MA 02115, USA
    Semin Respir Crit Care Med 26:265-72. 2005
    ..Molecular epidemiological studies are now focused on building larger databases from existing smaller studies and developing strategies to simultaneously evaluate multiple polymorphisms and genes within the same pathway...
  45. ncbi request reprint Polymorphisms of vitamin D receptor and survival in early-stage non-small cell lung cancer patients
    Wei Zhou
    Departments of Environmental Health, Occupational Health Program, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 15:2239-45. 2006
    ..71). Similar associations were found in haplotype analysis and for RFS among SCC patients. In conclusion, VDR polymorphisms may be associated with improved survival among SCC patients of early-stage NSCLC...
  46. ncbi request reprint Matrix metalloproteinase polymorphisms and survival in stage I non-small cell lung cancer
    Rebecca Suk Heist
    Massachusetts General Hospital and Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Clin Cancer Res 12:5448-53. 2006
    ..We hypothesized that polymorphisms in these MMP genes may be associated with survival outcomes in early-stage non-small cell lung cancer (NSCLC)...
  47. ncbi request reprint Genotypes and haplotypes of matrix metalloproteinase 1, 3 and 12 genes and the risk of lung cancer
    Li Su
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Carcinogenesis 27:1024-9. 2006
    ..62-8.20) when compared with the most common 1G-5A-82A-1082A haplotype. In conclusion, the combined MMP genotypes and associated haplotypes may be associated with higher risk of lung cancer, particularly among never smokers and men...
  48. doi request reprint VEGF polymorphisms and survival in early-stage non-small-cell lung cancer
    Rebecca Suk Heist
    Massachusetts General Hospital, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    J Clin Oncol 26:856-62. 2008
    ..Polymorphisms in the VEGF gene have been identified that are believed to have functional activity. We hypothesized that such polymorphisms may affect survival outcomes among early-stage non-small-cell lung cancer (NSCLC) patients...
  49. pmc Association of UGT1A1*28 polymorphisms with irinotecan-induced toxicities in colorectal cancer: a meta-analysis in Caucasians
    X Liu
    1 Ontario Cancer Institute, Toronto, ON, Canada 2 School of Laboratory Medicine, Hubei University of Chinese Medicine, Wuhan, China
    Pharmacogenomics J 14:120-9. 2014
    ..Although the toxicity relationships were much stronger with the UGT1A1*28 homozygous variant, associations were also found with the UGT1A1*28 heterozygous variant. ..
  50. pmc Pharmacologic reversal of epigenetic silencing of the anticancer protein BRM: a novel targeted treatment strategy
    S Gramling
    Division of Hematology Oncology, Department of Medicine, University of Florida, Gainesville, FL 32610, USA
    Oncogene 30:3289-94. 2011
    ..We therefore show, for the first time, that pharmacologic reversal of epigenetic changes of the SWI/SNF chromatic remodeling complex subunit, BRM, is a potentially viable and novel therapeutic approach...
  51. ncbi request reprint The combination of SKY and specific loci detection with FISH or immunostaining
    C J Ye
    SeeDNA Biotech Inc, Windsor, Ontario, Canada
    Cytogenet Cell Genet 93:195-202. 2001
    ..It is particularly useful when simultaneously monitoring the behavior of both protein complexes and DNA loci within the genome. The details of this methodology are described and systematically tested in this communication...
  52. pmc IL-6 promotes prostate tumorigenesis and progression through autocrine cross-activation of IGF-IR
    A Rojas
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    Oncogene 30:2345-55. 2011
    ..Our findings suggest that STAT3 and IGF-IR may represent potential effective targets for prevention or treatment of prostate cancer...
  53. doi request reprint Genetic polymorphisms and head and neck cancer outcomes: a review
    Jessica Hopkins
    Community Medicine Residency Program and Department of Family Medicine, McMaster University, Hamilton, Ontario, Canada
    Cancer Epidemiol Biomarkers Prev 17:490-9. 2008
    ..Despite a large number of exploratory studies, large replication studies in well-characterized HNC populations are warranted...
  54. ncbi request reprint Dietary iron, zinc, and calcium and the risk of lung cancer
    Wei Zhou
    Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, and the Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02115, USA
    Epidemiology 16:772-9. 2005
    ..Dietary intakes of these micronutrients have been associated with altered risks of colorectal, breast, and prostate cancers...
  55. pmc Circulating 25-hydroxyvitamin D, VDR polymorphisms, and survival in advanced non-small-cell lung cancer
    Rebecca Suk Heist
    Massachusetts General Hospital, USA
    J Clin Oncol 26:5596-602. 2008
    ..We hypothesized that vitamin D levels and VDR polymorphisms may also affect survival among patients with advanced NSCLC...
  56. pmc A Large-scale genetic association study of esophageal adenocarcinoma risk
    Chen Yu Liu
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Carcinogenesis 31:1259-63. 2010
    ....
  57. ncbi request reprint Smoking cessation before diagnosis and survival in early stage non-small cell lung cancer patients
    Wei Zhou
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Lung Cancer 53:375-80. 2006
    ..In conclusion, smoking cessation is associated with improved survival in early stage NSCLC patients. The longer the time since cessation of smoking, the better the survival outcome...
  58. ncbi request reprint Circulating 25-hydroxyvitamin D levels predict survival in early-stage non-small-cell lung cancer patients
    Wei Zhou
    Departments of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    J Clin Oncol 25:479-85. 2007
    ..We further investigated the results of circulating 25-hydroxyvitamin D (25[OH]D) levels on overall survival (OS) and recurrence-free survival (RFS) in NSCLC patients...
  59. ncbi request reprint An association between glutathione S-transferase P1 gene polymorphism and younger age at onset of lung carcinoma
    David P Miller
    Department of Environmental Heath, Occupational Health Program, Harvard School of Public Health, Boston, Massachusetts, USA
    Cancer 107:1570-7. 2006
    ..The variant GSTP1 GG genotype is associated with lower enzymatic activity and higher DNA adduct levels in human lymphocytes compared with the AA genotype...
  60. ncbi request reprint Myeloperoxidase and superoxide dismutase polymorphisms are associated with an increased risk of developing pancreatic adenocarcinoma
    Paul Wheatley-Price
    Department of Medical Oncology and Hematology, Department of Medicine, Princess Margaret Hospital, Toronto, Ontario, Canada
    Cancer 112:1037-42. 2008
    ..Myeloperoxidase (MPO) and superoxide dismutase (SOD2) are enzymes that regulate reactive oxygen species and contain recognized single nucleotide polymorphisms (SNPs) that confer altered enzyme activity...
  61. ncbi request reprint A novel and simplified route to the synthesis of N3S chelators for 99mTc labeling
    Z Zhu
    Division of Nuclear Medicine, Department of Radiology, University of Massachusetts Medical School, Worcester, MA, USA
    Nucl Med Biol 28:703-8. 2001
    ..We conclude that this synthesis route provides a simplified path to the synthesis of N(3)S chelators which in principle may be used to incorporate any natural or unnatural amino acid...
  62. pmc A comparison of batch effect removal methods for enhancement of prediction performance using MAQC-II microarray gene expression data
    J Luo
    Systems Analytics Inc, Waltham, MA, USA
    Pharmacogenomics J 10:278-91. 2010
    ....
  63. ncbi request reprint Determinants of bone mineral density in Chinese-American women
    M D Walker
    Department of Medicine, College of Physicians and Surgeons, Columbia University, PH8W 864, 630 West 168th Street, New York, NY 10032, USA
    Osteoporos Int 18:471-8. 2007
    ..We identified determinants of BMD among 359 Chinese-American women in order to identify risk factors for low BMD in this burgeoning population. BMD in Chinese-American women is influenced by a number of factors, including immigration...
  64. ncbi request reprint Harvesting the genome's bounty: integrative genomics
    P Jorgensen
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5
    Cold Spring Harb Symp Quant Biol 68:431-43. 2003
  65. ncbi request reprint Hydrogen peroxide-mediated, lysyl oxidase-dependent chemotaxis of vascular smooth muscle cells
    W Li
    Department of Microbiology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Cell Biochem 78:550-7. 2000
    ..The addition of LO to VSMC elevated the levels of intracellular H(2)O(2), enhanced stress fiber formation, and focal adhesion assembly, is consistent with the induction of the chemotactic response...
  66. pmc Regulation of type-II collagen gene expression during human chondrocyte de-differentiation and recovery of chondrocyte-specific phenotype in culture involves Sry-type high-mobility-group box (SOX) transcription factors
    D G Stokes
    Department of Medicine, Division of Rheumatology, 233 S 10th Street, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Biochem J 360:461-70. 2001
    ..These results underscore the overt change in phenotype that occurs when chondrocytes are cultured as monolayers on tissue-culture plastic substrata...
  67. ncbi request reprint Risk and predictors for pregnancy-related complications in women with heart disease
    S C Siu
    Department of Medicine, The Toronto Hospital, Ontario, Canada
    Circulation 96:2789-94. 1997
    ..Prior studies have focused on specific cardiac lesions or identified univariate predictors. There is a need to refine the risk stratification of women with heart disease so they can receive appropriate obstetrical counseling and care...
  68. ncbi request reprint Enhancing forest carbon sequestration in China: toward an integration of scientific and socio-economic perspectives
    J M Chen
    Department of Geography, University of Toronto, 100 St George Street, Room 5047, Toronto, ON, Canada M5S 3G3
    J Environ Manage 85:515-23. 2007
    ..Articles included in this special issue are highlights of the results of each of these components...
  69. ncbi request reprint Early changes in gene expression that influence the course of primary glomerular disease
    L C Clement
    Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Kidney Int 72:337-47. 2007
    ..Our studies suggest that an early and persistent change in mostly steroid-resistant glomerular gene expression is the hallmark of severe and progressive glomerular disease...
  70. ncbi request reprint Second hand smoke exposure and survival in early-stage non-small-cell lung cancer patients
    Wei Zhou
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Clin Cancer Res 12:7187-93. 2006
    ..Second hand smoke (SHS) exposure is associated with higher risk of lung cancer. However, the role of SHS in lung cancer survival is not clear...
  71. doi request reprint Phase II study of preoperative gefitinib in clinical stage I non-small-cell lung cancer
    Humberto Lara-Guerra
    University Ave, Toronto, Ontario, Canada M5G 2M9
    J Clin Oncol 27:6229-36. 2009
    ..Their role in early-stage NSCLC has not been established. Our purpose was to explore the use of preoperative gefitinib in clinical stage I NSCLC to assess tumor response, toxicity, and clinical and molecular predictors of response...
  72. ncbi request reprint P53 (codon 72) and P21 (codon 31) polymorphisms alter in vivo mRNA expression of p21
    Li Su
    Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Lung Cancer 40:259-66. 2003
    ..Results were consistent in both patients with lung cancer (n=63) and in normal controls (n=21). In conclusion, the presence of a p53 Pro allele and/or p21 Arg allele is associated with lower downstream target gene expression of p21...
  73. doi request reprint A rapid outcomes ascertainment system improves the quality of prognostic and pharmacogenetic outcomes from observational studies
    Penelope A Bradbury
    Princess Margaret Hospital Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario, Canada
    Cancer Epidemiol Biomarkers Prev 17:204-11. 2008
    ..Using clinical trial and epidemiologic methods, we assessed the quality of prognostic and outcomes data obtainable from a large case-control study of lung cancer...
  74. ncbi request reprint Vitamin D is associated with improved survival in early-stage non-small cell lung cancer patients
    Wei Zhou
    Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 14:2303-9. 2005
    ..In conclusion, the joint effects of surgery season and recent vitamin D intake seem to be associated with the survival of early-stage non-small cell lung cancer patients...
  75. ncbi request reprint Genetic polymorphisms of MnSOD, GSTM1, GSTT1, and OGG1 in coal workers' pneumoconiosis
    Rihong Zhai
    Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    J Occup Environ Med 44:372-7. 2002
    ..Cumulative dust exposures, but not genetic polymorphisms, were associated significantly with the presence of CWP. This study illustrates the complexity of factors that may contribute to the development of CWP...
  76. doi request reprint A comprehensive catalogue of functional genetic variations in the EGFR pathway: protein-protein interaction analysis reveals novel genes and polymorphisms important for cancer research
    Sevtap Savas
    Division of Applied Molecular Oncology, Department of Medical Biophysics, Ontario Cancer Institute, Toronto, Ontario, Canada
    Int J Cancer 125:1257-65. 2009
    ..The genes and their SNPs identified in the network-based analysis represent potential candidates for gene-gene and SNP-SNP interaction studies in cancer research...
  77. doi request reprint Genetic variations as cancer prognostic markers: review and update
    Sevtap Savas
    Department of Medical Biophysics, Division of Applied Molecular Oncology, Ontario Cancer Institute, Toronto, Ontario, Canada
    Hum Mutat 30:1369-77. 2009
    ..We discuss the interrelatedness among the disease susceptibility, treatment response, and prognosis at the genetic level and focus on how the emerging technologies and approaches can uniquely benefit the genetic prognosis studies...
  78. ncbi request reprint Studying genetic variations in cancer prognosis (and risk): a primer for clinicians
    Sevtap Savas
    Division of Applied Molecular Oncology, Department of Medical Biophysics, Ontario Cancer Institute, Toronto, Canada
    Oncologist 14:657-66. 2009
    ..In this review, we summarize the current knowledge on how candidate genes and genetic variations are selected to evaluate gene-outcome, gene-prognosis, and gene-treatment response relationships as applicable to the practicing oncologist...
  79. pmc Modeling lung cancer risk in case-control studies using a new dose metric of smoking
    Sally W Thurston
    Department of Biostatistics and Computational Biology, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Cancer Epidemiol Biomarkers Prev 14:2296-302. 2005
    ..In conclusion, we provide a general framework for evaluating different smoking metrics in studies where smoking is a critical variable...
  80. ncbi request reprint Risk of pancreatic cancer among individuals with a family history of cancer of the pancreas
    Parviz Ghadirian
    Centre de Recherche, CHUM Hotel Dieu, Montreal, Quebec, Canada
    Int J Cancer 97:807-10. 2002
    ..Familial site-specific pancreatic cancer appears to be a distinct genetic entity, but contributes only modestly to the total burden of pancreatic cancer...
  81. ncbi request reprint Excision repair cross-complementation group 1 polymorphism predicts overall survival in advanced non-small cell lung cancer patients treated with platinum-based chemotherapy
    Wei Zhou
    Occupational Health Program, Departments of Environmental Health and Biostatistics, Harvard School of Public Health, Boston 02115, Massachusetts, USA
    Clin Cancer Res 10:4939-43. 2004
    ..9 (T/T), 16.1 (C/T), and 13.3 (C/C) months, respectively. In conclusion, the ERCC1 C8092A polymorphism may be a useful predictor of OS in advanced non-small cell lung cancer patients treated with platinum-based chemotherapy...
  82. ncbi request reprint Serum proteomic classifier for predicting response to epidermal growth factor receptor inhibitor therapy: have we built a better mousetrap?
    Ming Sound Tsao
    J Natl Cancer Inst 99:826-7. 2007
  83. doi request reprint A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25
    Rayjean J Hung
    International Agency for Research on Cancer IARC, Lyon 69008, France
    Nature 452:633-7. 2008
    ..Our results provide compelling evidence of a locus at 15q25 predisposing to lung cancer, and reinforce interest in nicotinic acetylcholine receptors as potential disease candidates and chemopreventative targets...
  84. pmc Second hand smoke, age of exposure and lung cancer risk
    Kofi Asomaning
    Department of Environmental Heath Environmental and Occupational Medicine and Epidemiology Program, Harvard School of Public Health, Boston, MA 02115, United States
    Lung Cancer 61:13-20. 2008
    ..e. in the earlier part of life (0-25 years of age) the risk of lung cancer is greater compared to an exposure occurring after age 25...

Research Grants4

  1. Molecular Epidemiology of Esophageal Cancer Prognosis
    Geoffrey Liu; Fiscal Year: 2004
    ..Furthermore, the proposed studies address directly a prioritized research area identified by the NCI Stomach and Esophageal Cancers Progress Review Group (Year 2002). ..
  2. Molecular Epidemiology of Esophageal Cancer Prognosis
    Geoffrey Liu; Fiscal Year: 2005
    ..Furthermore, the proposed studies address directly a prioritized research area identified by the NCI Stomach and Esophageal Cancers Progress Review Group (Year 2002). ..
  3. Molecular Epidemiology of Esophageal Cancer Prognosis
    Geoffrey Liu; Fiscal Year: 2007
    ..Furthermore, the proposed studies address directly a prioritized research area identified by the NCI Stomach and Esophageal Cancers Progress Review Group (Year 2002). ..