G F Lewis

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. pmc Sodium phenylbutyrate, a drug with known capacity to reduce endoplasmic reticulum stress, partially alleviates lipid-induced insulin resistance and beta-cell dysfunction in humans
    Changting Xiao
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Diabetes 60:918-24. 2011
  2. pmc Effects of acute hyperglucagonemia on hepatic and intestinal lipoprotein production and clearance in healthy humans
    Changting Xiao
    Department of Medicine, Division of Endocrinology and Metabolism, University of Toronto, Toronto, Ontario, Canada
    Diabetes 60:383-90. 2011
  3. pmc Insulin acutely inhibits intestinal lipoprotein secretion in humans in part by suppressing plasma free fatty acids
    Mirjana Pavlic
    Division of Endocrinology and Metabolism, Department of Medicine and Physiology, University of Toronto, Toronto, Canada
    Diabetes 59:580-7. 2010
  4. ncbi request reprint Mechanisms of incretin effects on plasma lipids and implications for the cardiovascular system
    Changting Xiao
    Departments of Medicine and Physiology, University of Toronto, Toronto, ON, Canada
    Cardiovasc Hematol Agents Med Chem 10:289-94. 2012
  5. ncbi request reprint Are the lipid-modifying effects of fibrates mediated by alterations in plasma lipid transfer activity?
    Gary F Lewis
    Toronto General Hospital, 200 Elizabeth Street, EN12 218, Toronto, ON, Canada M5G 2C4
    Clin Sci (Lond) 111:185-7. 2006
  6. ncbi request reprint Determinants of plasma HDL concentrations and reverse cholesterol transport
    Gary F Lewis
    Department of Medicine, University of Toronto, Ontario, Canada
    Curr Opin Cardiol 21:345-52. 2006
  7. ncbi request reprint Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes
    Gary F Lewis
    Department of Medicine, Division of Endocrinology, University of Toronto, Canada M5G 2C4
    Endocr Rev 23:201-29. 2002
  8. ncbi request reprint Hepatic lipase mRNA, protein, and plasma enzyme activity is increased in the insulin-resistant, fructose-fed Syrian golden hamster and is partially normalized by the insulin sensitizer rosiglitazone
    Gary F Lewis
    Department of Medicine and Physiology, Division of Endocrinology and Metabolism, University of Toronto, Ontario, Canada
    Diabetes 53:2893-900. 2004
  9. doi request reprint The effect of high-dose sodium salicylate on chronically elevated plasma nonesterified fatty acid-induced insulin resistance and β-cell dysfunction in overweight and obese nondiabetic men
    Changting Xiao
    Departments of Medicine and Physiology, University of Toronto, Toronto, Ontario, Canada
    Am J Physiol Endocrinol Metab 297:E1205-11. 2009
  10. ncbi request reprint Intestinal lipoprotein overproduction, a newly recognized component of insulin resistance, is ameliorated by the insulin sensitizer rosiglitazone: studies in the fructose-fed Syrian golden hamster
    Gary F Lewis
    Department of Medicine, Division of Endocrinology and Metabolism, Hospital for Sick Children, Univeristy of Toronto, Toronto, Ontario, Canada
    Endocrinology 146:247-55. 2005

Collaborators

Detail Information

Publications62

  1. pmc Sodium phenylbutyrate, a drug with known capacity to reduce endoplasmic reticulum stress, partially alleviates lipid-induced insulin resistance and beta-cell dysfunction in humans
    Changting Xiao
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Diabetes 60:918-24. 2011
    ..Here we examined the efficacy of the chemical chaperone, sodium phenylbutyrate (PBA), a drug with known capacity to reduce ER stress in animal models and in vitro, on lipid-induced insulin resistance and β-cell dysfunction in humans...
  2. pmc Effects of acute hyperglucagonemia on hepatic and intestinal lipoprotein production and clearance in healthy humans
    Changting Xiao
    Department of Medicine, Division of Endocrinology and Metabolism, University of Toronto, Toronto, Ontario, Canada
    Diabetes 60:383-90. 2011
    ..Here we examined the direct effects of glucagon on regulation of hepatic and intestinal lipoprotein metabolism in humans...
  3. pmc Insulin acutely inhibits intestinal lipoprotein secretion in humans in part by suppressing plasma free fatty acids
    Mirjana Pavlic
    Division of Endocrinology and Metabolism, Department of Medicine and Physiology, University of Toronto, Toronto, Canada
    Diabetes 59:580-7. 2010
    ..Here, we investigated the effect of acute hyperinsulinemia on intestinal (and hepatic) lipoprotein production in six healthy men in the presence and absence of concomitant suppression of plasma free fatty acids (FFAs)...
  4. ncbi request reprint Mechanisms of incretin effects on plasma lipids and implications for the cardiovascular system
    Changting Xiao
    Departments of Medicine and Physiology, University of Toronto, Toronto, ON, Canada
    Cardiovasc Hematol Agents Med Chem 10:289-94. 2012
    ..This review aims to summarize the evidence and potential mechanism of such agents in humans in modulating fasting and postprandial lipoprotein metabolism...
  5. ncbi request reprint Are the lipid-modifying effects of fibrates mediated by alterations in plasma lipid transfer activity?
    Gary F Lewis
    Toronto General Hospital, 200 Elizabeth Street, EN12 218, Toronto, ON, Canada M5G 2C4
    Clin Sci (Lond) 111:185-7. 2006
    ....
  6. ncbi request reprint Determinants of plasma HDL concentrations and reverse cholesterol transport
    Gary F Lewis
    Department of Medicine, University of Toronto, Ontario, Canada
    Curr Opin Cardiol 21:345-52. 2006
    ..This review focuses on recent progress in our understanding of reverse cholesterol transport and the factors that determine plasma HDL cholesterol concentrations...
  7. ncbi request reprint Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes
    Gary F Lewis
    Department of Medicine, Division of Endocrinology, University of Toronto, Canada M5G 2C4
    Endocr Rev 23:201-29. 2002
    ....
  8. ncbi request reprint Hepatic lipase mRNA, protein, and plasma enzyme activity is increased in the insulin-resistant, fructose-fed Syrian golden hamster and is partially normalized by the insulin sensitizer rosiglitazone
    Gary F Lewis
    Department of Medicine and Physiology, Division of Endocrinology and Metabolism, University of Toronto, Ontario, Canada
    Diabetes 53:2893-900. 2004
    ....
  9. doi request reprint The effect of high-dose sodium salicylate on chronically elevated plasma nonesterified fatty acid-induced insulin resistance and β-cell dysfunction in overweight and obese nondiabetic men
    Changting Xiao
    Departments of Medicine and Physiology, University of Toronto, Toronto, Ontario, Canada
    Am J Physiol Endocrinol Metab 297:E1205-11. 2009
    ..These data suggest that oral sodium salicylate at this dose impairs insulin clearance but does not ameliorate lipid-induced insulin resistance and β-cell dysfunction in overweight and obese nondiabetic men...
  10. ncbi request reprint Intestinal lipoprotein overproduction, a newly recognized component of insulin resistance, is ameliorated by the insulin sensitizer rosiglitazone: studies in the fructose-fed Syrian golden hamster
    Gary F Lewis
    Department of Medicine, Division of Endocrinology and Metabolism, Hospital for Sick Children, Univeristy of Toronto, Toronto, Ontario, Canada
    Endocrinology 146:247-55. 2005
    ..The data suggest that intestinal lipoprotein overproduction can be ameliorated with the insulin sensitizer rosiglitazone...
  11. ncbi request reprint Intestinal lipoprotein production is stimulated by an acute elevation of plasma free fatty acids in the fasting state: studies in insulin-resistant and insulin-sensitized Syrian golden hamsters
    Gary F Lewis
    Toronto General Hospital, 200 Elizabeth Street, EN11 229, Toronto, Ontario, Canada
    Endocrinology 145:5006-12. 2004
    ..With RSG treatment, basal PR is partially normalized, and they become more susceptible to the acute FFA stimulatory effect...
  12. ncbi request reprint Lipid metabolism
    Gary F Lewis
    Department of Medicine and Physiology, University of Toronto, Toronto, Ontario, Canada
    Curr Opin Lipidol 15:85-7. 2004
  13. ncbi request reprint New insights into the regulation of HDL metabolism and reverse cholesterol transport
    Gary F Lewis
    Department of Medicine and Physiology, University of Toronto, Canada
    Circ Res 96:1221-32. 2005
    ....
  14. ncbi request reprint Fatty acids mediate the acute extrahepatic effects of insulin on hepatic glucose production in humans
    G F Lewis
    Department of Medicine, University of Toronto, Ontario, Canada
    Diabetes 46:1111-9. 1997
    ..This suggests that other mechanisms, most likely hepatic, dominate the acute insulin-induced suppression of glucose production...
  15. ncbi request reprint Counterregulatory response to hypoglycemia differs according to the insulin delivery route, but does not affect glucose production in normal humans
    G F Lewis
    Department of Medicine, University of Toronto, Ontario, Canada
    J Clin Endocrinol Metab 84:1037-46. 1999
    ..The clinical importance of these observations in diabetic subjects as they relate to route of insulin delivery (portal or peripheral) during insulin dissipation remains to be determined...
  16. ncbi request reprint Resistance to insulin's acute direct hepatic effect in suppressing steady-state glucose production in individuals with type 2 diabetes
    G F Lewis
    Department of Medicine, University of Toronto, Ontario, Canada
    Diabetes 48:570-6. 1999
    ..In conclusion, this is the first study in patients with type 2 diabetes to characterize insulin resistance to the acute direct suppressive effect of insulin on hepatic glucose production...
  17. ncbi request reprint Effect of increased plasma non-esterified fatty acids (NEFAs) on arginine-stimulated insulin secretion in obese humans
    A Carpentier
    Department of Medicine, Division of Endocrinology, University of Toronto, Toronto General Hospital, Toronto, Ontario, Canada
    Diabetologia 44:1989-97. 2001
    ..These findings suggest that the previously demonstrated NEFA-induced impairment in insulin secretory response to glucose cannot be generalized for non-glucose secretagogues...
  18. ncbi request reprint Prolonged increase of plasma non-esterified fatty acids fully abolishes the stimulatory effect of 24 hours of moderate hyperglycaemia on insulin sensitivity and pancreatic beta-cell function in obese men
    N Leung
    Department of Medicine, Division of Endocrinology and Metabolism and the Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    Diabetologia 47:204-13. 2004
    ..A prolonged increase of plasma NEFA impairs acute glucose-stimulated insulin secretion (GSIS) in vitro and in vivo. Our study therefore examined the combined effect of increased plasma NEFA and glucose on GSIS in humans...
  19. ncbi request reprint The effect of systemic versus portal insulin delivery in pancreas transplantation on insulin action and VLDL metabolism
    A Carpentier
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Diabetes 50:1402-13. 2001
    ....
  20. ncbi request reprint Mechanisms of hepatic very low-density lipoprotein overproduction in insulin resistance
    K Adeli
    Division of Clinical Biochemistry, Department of Laboratory Medicine and Pathobiology, Hospital for Sick Children, University of Toeonto, Toronto, Ontario, Canada
    Trends Cardiovasc Med 11:170-6. 2001
    ..g., in streptozotocin-treated animals), which appears to have a different etiology and is related to a catabolic defect rather than secretory overproduction of triglyceride-rich lipoproteins...
  21. ncbi request reprint Fasting and postprandial overproduction of intestinally derived lipoproteins in an animal model of insulin resistance. Evidence that chronic fructose feeding in the hamster is accompanied by enhanced intestinal de novo lipogenesis and ApoB48-containing li
    Mehran Haidari
    Department of Laboratory Medicine and Pathobiology, Hospital for Sick Children, University of Toronto, Toronto, Ontario M5G 1X8, Canada
    J Biol Chem 277:31646-55. 2002
    ....
  22. ncbi request reprint Ameliorated hepatic insulin resistance is associated with normalization of microsomal triglyceride transfer protein expression and reduction in very low density lipoprotein assembly and secretion in the fructose-fed hamster
    Andre Carpentier
    Department of Medicine, Division of Endocrinology and Metabolism, University Health Network, Hospital for Sick Children, University of Toronto, Toronto, Ontario M5G 2C4, Canada
    J Biol Chem 277:28795-802. 2002
    ....
  23. ncbi request reprint Mechanisms of HDL lowering in insulin resistant, hypertriglyceridemic states: the combined effect of HDL triglyceride enrichment and elevated hepatic lipase activity
    Shirya Rashid
    Department of Medicine, Division of Endocrinology, University of Toronto, Toronto, Ontario, Canada
    Clin Biochem 36:421-9. 2003
    ..The present review focuses on these metabolic alterations in insulin resistant states and their important contributions to the reduction of HDL-c and HDL-apoA-I plasma concentrations...
  24. doi request reprint Enhanced cellular uptake of remnant high-density lipoprotein particles: a mechanism for high-density lipoprotein lowering in insulin resistance and hypertriglyceridemia
    Changting Xiao
    Department of Medicine and Physiology, University of Toronto, Ontario, Canada
    Circ Res 103:159-66. 2008
    ....
  25. ncbi request reprint Triglyceride enrichment of HDL does not alter HDL-selective cholesteryl ester clearance in rabbits
    S Rashid
    Department of Medicine, Division of Endocrinology, University of Toronto, Toronto, Ontario, Canada M5G 2C4
    J Lipid Res 42:265-71. 2001
    ..Further studies are needed to determine whether, in the presence of HL, TG enrichment of HDL alters selective HDL CE clearance...
  26. doi request reprint Dissociation between the insulin-sensitizing effect of rosiglitazone and its effect on hepatic and intestinal lipoprotein production
    Hélène Duez
    Departments of Medicine and Physiology, Toronto General Hospital, 200 Elizabeth Street, Toronto, Ontario, Canada
    J Clin Endocrinol Metab 93:1722-9. 2008
    ..The mechanism of this effect is currently not known...
  27. ncbi request reprint Oral taurine but not N-acetylcysteine ameliorates NEFA-induced impairment in insulin sensitivity and beta cell function in obese and overweight, non-diabetic men
    C Xiao
    Department of Medicine, University of Toronto, Toronto, ON, Canada
    Diabetologia 51:139-46. 2008
    ..The aim of the present study was to examine the effects of two orally administered antioxidants, N-acetylcysteine (NAC) and taurine (TAU), on lipotoxicity in humans...
  28. ncbi request reprint Hyperinsulinemia is associated with increased production rate of intestinal apolipoprotein B-48-containing lipoproteins in humans
    Hélène Duez
    Division of Endocrinology and Metabolism, Department of Medicine, University of Toronto, Ontario, Canada
    Arterioscler Thromb Vasc Biol 26:1357-63. 2006
    ....
  29. pmc Triglyceride-rich lipoprotein-associated apolipoprotein C-III production is stimulated by plasma free fatty acids in humans
    Mirjana Pavlic
    Department of Medicine, University of Toronto, Canada
    Arterioscler Thromb Vasc Biol 28:1660-5. 2008
    ..The mechanism underlying that increase is not known, but because apoC-III and VLDL production are closely linked we hypothesized that FFAs may stimulate TRL apoC-III production...
  30. ncbi request reprint Rosiglitazone improves intestinal lipoprotein overproduction in the fat-fed Syrian Golden hamster, an animal model of nutritionally-induced insulin resistance
    Nathalie Leung
    Department of Medicine, University of Toronto, Toronto, Ont, Canada
    Atherosclerosis 174:235-41. 2004
    ..These data further support the link between insulin resistance and intestinal lipoprotein overproduction...
  31. ncbi request reprint Lipolytically modified triglyceride-enriched HDLs are rapidly cleared from the circulation
    Shirya Rashid
    Department of Medicine, Division of Endocrinology, University of Toronto, Canada
    Arterioscler Thromb Vasc Biol 22:483-7. 2002
    ..These data further support the important interaction between HDL TG enrichment and HL action in the pathogenesis of HDL lowering in hypertriglyceridemic states...
  32. ncbi request reprint Differential effects of monounsaturated, polyunsaturated and saturated fat ingestion on glucose-stimulated insulin secretion, sensitivity and clearance in overweight and obese, non-diabetic humans
    C Xiao
    Department of Medicine and Physiology, University of Toronto, Toronto, ON, Canada
    Diabetologia 49:1371-9. 2006
    ..Prolonged elevation of plasma specific fatty acids may exert differential effects on glucose-stimulated insulin secretion (GSIS), insulin sensitivity and clearance...
  33. pmc Portal venous and enteric exocrine drainage versus systemic venous and bladder exocrine drainage of pancreas grafts: clinical outcome of 40 consecutive transplant recipients
    M S Cattral
    Multiorgan Transplantation Program, The Toronto General Hospital, University Health Network, and the Departments of Surgery and Medicine, University of Toronto, Toronto, Ontario, Canada
    Ann Surg 232:688-95. 2000
    ....
  34. ncbi request reprint Free fatty acid-mediated impairment of glucose-stimulated insulin secretion in nondiabetic Oji-Cree individuals from the Sandy Lake community of Ontario, Canada: a population at very high risk for developing type 2 diabetes
    Andre Carpentier
    Department of Medicine, University of Sherbrooke, Sherbrooke, Quebec, Canada
    Diabetes 52:1485-95. 2003
    ..Whether this reflects an inherent resistance to lipotoxicity or an already-present lipotoxic effect in this population will require further study...
  35. ncbi request reprint Expression of human hepatic lipase in the rabbit model preferentially enhances the clearance of triglyceride-enriched versus native high-density lipoprotein apolipoprotein A-I
    Shirya Rashid
    Department of Medicine, Division of Endocrinology, University of Toronto, Toronto, Canada
    Circulation 107:3066-72. 2003
    ..Here, we examined in the rabbit the interaction between in vivo HL lipolytic action and HDL TG enrichment on the subsequent metabolic clearance of HDL apoA-I...
  36. doi request reprint Intestinal lipoprotein overproduction in insulin-resistant states
    Khosrow Adeli
    Molecular Structure and Function, Research Institute, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Curr Opin Lipidol 19:221-8. 2008
    ..This article will review our current understanding of the link between insulin resistance and intestinal lipoprotein overproduction and highlight some of the key recent findings in the field...
  37. ncbi request reprint Hepatic very low density lipoprotein-ApoB overproduction is associated with attenuated hepatic insulin signaling and overexpression of protein-tyrosine phosphatase 1B in a fructose-fed hamster model of insulin resistance
    Changiz Taghibiglou
    Division of Clinical Biochemistry, Department of Laboratory Medicine and Pathobiology, Hospital for Sick Children, University of Toronto, Toronto, Ontario M5G 1X8, Canada
    J Biol Chem 277:793-803. 2002
    ..Induction of hepatic insulin resistance may then contribute to reduced apoB degradation and enhanced VLDL particle assembly and secretion...
  38. ncbi request reprint Free fatty acid-induced reduction in glucose-stimulated insulin secretion: evidence for a role of oxidative stress in vitro and in vivo
    Andrei I Oprescu
    Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
    Diabetes 56:2927-37. 2007
    ..Our objective was to investigate the role of oxidative stress in FFA-induced decrease in beta-cell function...
  39. ncbi request reprint Effect of atorvastatin on high-density lipoprotein apolipoprotein A-I production and clearance in the New Zealand white rabbit
    Shirya Rashid
    Department of Medicine, Division of Endocrinology, University of Toronto, Toronto, Canada
    Circulation 106:2955-60. 2002
    ..We therefore studied the effect of atorvastatin on HDL apolipoprotein (apo) A-I production and clearance in normolipidemic male New Zealand White rabbits...
  40. ncbi request reprint Sensitivity to acute insulin-mediated suppression of plasma free fatty acids is not a determinant of fasting VLDL triglyceride secretion in healthy humans
    Andre Carpentier
    Department of Medicine, Division of Endocrinology, University of Toronto, Ontario, Canada
    Diabetes 51:1867-75. 2002
    ..The sensitivity to insulin's acute suppressive effect on plasma FFA levels during fasting is not an important determinant of postabsorptive VLDL-TG secretion in humans...
  41. doi request reprint Acute cannabinoid receptor type 1 (CB1R) modulation influences insulin sensitivity by an effect outside the central nervous system in mice
    D Song
    Department of Medicine, University of Toronto, Toronto, ON, Canada
    Diabetologia 54:1181-9. 2011
    ..Here we examined the relative contributions of acute CNS and extra-CNS CB1R modulation on insulin sensitivity using pharmacological gain- and loss-of-function of CB1R in mice...
  42. ncbi request reprint Thiazolidinediones: novel treatments for cognitive deficits in mood disorders?
    Roger S McIntyre
    University of Toronto, Department of Psychiatry, Toronto, ON, Canada
    Expert Opin Pharmacother 8:1615-28. 2007
    ..Extant data provide the basis for formulating a hypothesis that TZDs may be salutary for cognitive deficits and several aspects of somatic health (e.g., cardiovascular disease) associated with mood disorders...
  43. ncbi request reprint Atorvastatin induces insulin sensitization in Zucker lean and fatty rats
    Victor Wong
    Department of Medicine, Division of Endocrinology and Metabolism, University of Toronto, Ont, Canada Department of Physiology, University of Toronto, Ont, Canada
    Atherosclerosis 184:348-55. 2006
    ..We investigated the effects of an HMG-CoA reductase inhibitor, atorvastatin, on insulin sensitization in Zucker lean and fatty rats...
  44. ncbi request reprint Managing psychiatric disorders with antidiabetic agents: translational research and treatment opportunities
    Roger S McIntyre
    Mood Disorders Psychopharmacology Unit, University Health Network, 399 Bathurst Street Toronto, ON, M5T 2S8, Canada
    Expert Opin Pharmacother 7:1305-21. 2006
    ..Antidiabetic treatments, which maintain euglycaemia, hold promise as potent and clinically significant therapeutic interventions for several neuropsychiatric disorders...
  45. ncbi request reprint Vasopeptidase inhibitor omapatrilat induces profound insulin sensitization and increases myocardial glucose uptake in Zucker fatty rats: Studies comparing a vasopeptidase inhibitor, angiotensin-converting enzyme inhibitor, and angiotensin II type I recept
    Chao Hung Wang
    Department of Medicine, Division of Endocrinology and Metabolism, Toronto General Hospital and University Health Network, Toronto, Ontario, Canada
    Circulation 107:1923-9. 2003
    ..The vasopeptidase inhibitor omapatrilat (OMA) raises BK to a greater extent than ACEIs by dual enzyme inhibition, whereas its insulin-sensitizing effects and mechanisms have not been investigated...
  46. ncbi request reprint The mechanism of HDL lowering in hypertriglyceridemic, insulin-resistant states
    Shirya Rashid
    Department of Medicine, Division of Endocrinology, University of Toronto, Toronto, Ontario, Canada
    J Diabetes Complications 16:24-8. 2002
    ..Clin. Chim. Acta 286 (1999) 145; J. Clin. Invest. 103 (8) (1999) 1191.] to support this hypothesis, in the present brief review, we will focus predominantly on our own recent research in this area...
  47. doi request reprint Mechanism of intestinal lipoprotein overproduction in insulin resistant humans
    Hélène Duez
    Department of Medicine, Division of Endocrinology, University of Toronto, Toronto, Canada
    Atheroscler Suppl 9:33-8. 2008
    ....
  48. ncbi request reprint Hepatic PTP-1B expression regulates the assembly and secretion of apolipoprotein B-containing lipoproteins: evidence from protein tyrosine phosphatase-1B overexpression, knockout, and RNAi studies
    Wei Qiu
    Department of Laboratory Medicine and Pathobiology, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Diabetes 53:3057-66. 2004
    ....
  49. ncbi request reprint Mechanism of highly active anti-retroviral therapy-induced hyperlipidemia in HIV-infected individuals
    Andre Carpentier
    The Department of Medicine, Division of Endocrinology, Universite de Sherbrooke, Que, Canada
    Atherosclerosis 178:165-72. 2005
    ..These changes occur concomitantly with an elevation of plasma free fatty acids but before significant change in body composition...
  50. ncbi request reprint Enhancement of muscle glucose uptake by the vasopeptidase inhibitor, omapatrilat, is independent of insulin signaling and the AMP kinase pathway
    Victor Wong
    Department of Medicine, Division of Endocrinology and Metabolism and the Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    J Endocrinol 190:441-50. 2006
    ..Future studies should examine whether hemodynamic effects of the drug, independent of insulin signaling, enhance glucose uptake in insulin-resistant skeletal muscle...
  51. pmc Both intestinal and hepatic lipoprotein production are stimulated by an acute elevation of plasma free fatty acids in humans
    Hélène Duez
    Department of Medicine, Division of Endocrinology and Metabolism, University of Toronto, Toronto, Canada
    Circulation 117:2369-76. 2008
    ..Here we investigated whether short-term elevation of plasma FFAs stimulates intestinal apolipoprotein (apo) B-48- and hepatic apoB-100-containing triglyceride-rich lipoprotein (TRL) production in humans in the fed state...
  52. ncbi request reprint Lipid-induced beta-cell dysfunction in vivo in models of progressive beta-cell failure
    Tracy T Goh
    Department of Physiology, University of Toronto, Toronto, ON, M5S 1A8, Canada
    Am J Physiol Endocrinol Metab 292:E549-60. 2007
    ..3) This compensation is lost in diabetic rats with more marked hyperglycemia and loss of glucose sensing...
  53. ncbi request reprint Deterioration in renal function associated with fibrate therapy
    J Lipscombe
    Division of Nephrology, University Health Network, Toronto, Canada
    Clin Nephrol 55:39-44. 2001
    ..If patients with pre-existing renal dysfunction are to receive a trial of fibrate therapy, this should be done with caution and..
  54. doi request reprint Acute dipeptidyl peptidase-4 inhibition rapidly enhances insulin-mediated suppression of endogenous glucose production in mice
    Hélène Duez
    Department of Medicine and Physiology, Division of Endocrinology and Metabolism, University of Toronto, Toronto, Ontario, Canada
    Endocrinology 150:56-62. 2009
    ..These findings illustrate that DPP-4 inhibition modulates glucose homeostasis through pathways distinct from those used by GLP-1R agonists in mice...
  55. ncbi request reprint Mechanisms of the free fatty acid-induced increase in hepatic glucose production
    Tony K T Lam
    Department of Physiology and Medicine, Medical Science Building, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Am J Physiol Endocrinol Metab 284:E863-73. 2003
    ..We review recent progress in this area and try to clarify controversial issues regarding the mechanisms responsible for the FFA-induced increase in hepatic glucose production in the postabsorptive state and during hyperinsulinemia...
  56. doi request reprint Short-term oral α-lipoic acid does not prevent lipid-induced dysregulation of glucose homeostasis in obese and overweight nondiabetic men
    Changting Xiao
    Department of Medicine, University of Toronto, Ontario, Canada
    Am J Physiol Endocrinol Metab 301:E736-41. 2011
    ..These results indicate that ALA, administered orally at this dose for 2 wk, does not protect against lipid-induced insulin resistance in overweight and obese humans...
  57. doi request reprint Gut-liver interaction in triglyceride-rich lipoprotein metabolism
    Changting Xiao
    Toronto General Hospital, ON, Canada
    Am J Physiol Endocrinol Metab 301:E429-46. 2011
    ..This review aims to integrate recent advances in our understanding of these processes and attempts to provide insight into the factors that coordinate lipid homeostasis in these two organs in health and disease...
  58. ncbi request reprint Overexpression of the endoplasmic reticulum 60 protein ER-60 downregulates apoB100 secretion by inducing its intracellular degradation via a nonproteasomal pathway: evidence for an ER-60-mediated and pCMB-sensitive intracellular degradative pathway
    Wei Qiu
    Division of Clinical Biochemistry, Department of Laboratory Medicine and Pathobiology, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada M5G 1X8
    Biochemistry 43:4819-31. 2004
    ..ER-60 may act directly as a protease or may be involved indirectly as a chaperone/protein factor targeting apoB100 to this nonproteasomal and pCMB-sensitive degradative pathway...
  59. ncbi request reprint Lipid metabolism
    Gary F Lewis
    Curr Opin Lipidol 13:97-9. 2002
  60. ncbi request reprint Thematic review series: patient-oriented research. What have we learned about HDL metabolism from kinetics studies in humans?
    Shirya Rashid
    Department of Cardiology, McGill University, Montreal, Canada
    J Lipid Res 47:1631-42. 2006
    ..Here, we review the progress in our understanding of HDL metabolism derived from in vivo kinetics studies, focusing primarily on studies in humans but also reviewing key studies in animal models...
  61. ncbi request reprint Objective evidence for the reversibility of nerve injury in diabetic neuropathic cachexia
    Jaspreet Grewal
    Diabetes Care 29:473-4. 2006
  62. ncbi request reprint Lipid metabolism
    Gary F Lewis
    Curr Opin Lipidol 14:103-6. 2003