A Levin

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. ncbi request reprint Vitamin D and its analogues: do they protect against cardiovascular disease in patients with kidney disease?
    Adeera Levin
    Division of Nephrology, University of British Columbia, Vancouver, Canada
    Kidney Int 68:1973-81. 2005
  2. doi request reprint Diabetes, kidney disease and cardiovascular disease patients. Assessing care of complex patients using outpatient testing and visits: additional metrics by which to evaluate health care system functioning
    Adeera Levin
    University of British Columbia, Vancouver, Canada
    Nephrol Dial Transplant 24:2714-20. 2009
  3. ncbi request reprint Activity-based funding model provides foundation for province-wide best practices in renal care
    Adeera Levin
    head of the Division of Nephrology and professor of medicine, Faculty of Medicine, University of British Columbia and executive director of the BC Provincial Renal Agency, in Vancouver, British Columbia Dr Levin is an academic clinician researcher and administrator involved in health outcomes research and translation of research findings into clinical care Dr Levin can be contacted at 604 682 2344, ext 62232, or by e mail at
    Healthc Q 16:49-54. 2013
  4. doi request reprint Targets, trends, excesses, and deficiencies: refocusing clinical investigation to improve patient outcomes
    Adeera Levin
    Division of Nephrology, University of British Columbia, Vancouver, British Columbia, Canada
    Kidney Int 83:1001-9. 2013
  5. pmc Cohort profile: Canadian study of prediction of death, dialysis and interim cardiovascular events (CanPREDDICT)
    Adeera Levin
    University of British Columbia, 1081 Burrard Street Room 6010A, Vancouver, BC V6Z1Y6, Canada
    BMC Nephrol 14:121. 2013
  6. doi request reprint Responsiveness of FGF-23 and mineral metabolism to altered dietary phosphate intake in chronic kidney disease (CKD): results of a randomized trial
    Mhairi Sigrist
    Division of Nephrology, University of British Columbia, Vancouver, British Columbia, Canada
    Nephrol Dial Transplant 28:161-9. 2013
  7. doi request reprint Towards rational approaches of health care utilization in complex patients: an exploratory randomized trial comparing a novel combined clinic to multiple specialty clinics in patients with renal disease-cardiovascular disease-diabetes
    Catherine Weber
    Department of Medicine, Division of Nephrology, St Paul s Hospital, University of British Columbia, Vancouver, Canada
    Nephrol Dial Transplant 27:iii104-10. 2012
  8. doi request reprint Incident isolated 1,25(OH)(2)D(3) deficiency is more common than 25(OH)D deficiency in CKD
    Adeera Levin
    BC Provincial Renal Agency, Vancouver, British Columbia, Canada
    J Nephrol 25:204-10. 2012
  9. doi request reprint Nondialysis chronic kidney disease in 2011: Progression, prediction, populations and possibilities
    Adeera Levin
    Division of Nephrology, Department of Medicine, St Paul s Hospital, University of British Columbia, 1081 Burrard Street, Room 6010 A, Vancouver, BC V6Z 1Y6, Canada
    Nat Rev Nephrol 8:70-2. 2012
  10. pmc Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury
    Ravindra L Mehta
    Department of Medicine, University of California San Diego Medical Center 8342, 200 W, Arbor Drive, San Diego, CA 92103, USA
    Crit Care 11:R31. 2007

Detail Information

Publications119 found, 100 shown here

  1. ncbi request reprint Vitamin D and its analogues: do they protect against cardiovascular disease in patients with kidney disease?
    Adeera Levin
    Division of Nephrology, University of British Columbia, Vancouver, Canada
    Kidney Int 68:1973-81. 2005
    ..In light of recent observational studies showing an association of vitamin D therapy and survival benefit in hemodialysis patients, the effects of vitamin D on cardiovascular system have become a heavily debated issue...
  2. doi request reprint Diabetes, kidney disease and cardiovascular disease patients. Assessing care of complex patients using outpatient testing and visits: additional metrics by which to evaluate health care system functioning
    Adeera Levin
    University of British Columbia, Vancouver, Canada
    Nephrol Dial Transplant 24:2714-20. 2009
    ..Patients with these conditions contribute excessively to health care costs. Opportunities for system redesign require metrics by which to evaluate the impact...
  3. ncbi request reprint Activity-based funding model provides foundation for province-wide best practices in renal care
    Adeera Levin
    head of the Division of Nephrology and professor of medicine, Faculty of Medicine, University of British Columbia and executive director of the BC Provincial Renal Agency, in Vancouver, British Columbia Dr Levin is an academic clinician researcher and administrator involved in health outcomes research and translation of research findings into clinical care Dr Levin can be contacted at 604 682 2344, ext 62232, or by e mail at
    Healthc Q 16:49-54. 2013
    ..Since its introduction, the outpatient renal services budget has grown less than the population, while maintaining or improving clinical outcomes. ..
  4. doi request reprint Targets, trends, excesses, and deficiencies: refocusing clinical investigation to improve patient outcomes
    Adeera Levin
    Division of Nephrology, University of British Columbia, Vancouver, British Columbia, Canada
    Kidney Int 83:1001-9. 2013
    ..Improved understanding of pathophysiological mechanisms, in conjunction with more innovative but stringent clinical trial design, will ultimately lead to improved patient outcomes...
  5. pmc Cohort profile: Canadian study of prediction of death, dialysis and interim cardiovascular events (CanPREDDICT)
    Adeera Levin
    University of British Columbia, 1081 Burrard Street Room 6010A, Vancouver, BC V6Z1Y6, Canada
    BMC Nephrol 14:121. 2013
    ..This information could then be used to better understand biological variation in outcomes, to develop clinical prediction models and to inform enrolment into interventional studies which may lead to novel treatments...
  6. doi request reprint Responsiveness of FGF-23 and mineral metabolism to altered dietary phosphate intake in chronic kidney disease (CKD): results of a randomized trial
    Mhairi Sigrist
    Division of Nephrology, University of British Columbia, Vancouver, British Columbia, Canada
    Nephrol Dial Transplant 28:161-9. 2013
    ..We studied the responsiveness of FGF-23 and mineral metabolism to altered dietary phosphate intake in chronic kidney disease (CKD) and healthy control patients...
  7. doi request reprint Towards rational approaches of health care utilization in complex patients: an exploratory randomized trial comparing a novel combined clinic to multiple specialty clinics in patients with renal disease-cardiovascular disease-diabetes
    Catherine Weber
    Department of Medicine, Division of Nephrology, St Paul s Hospital, University of British Columbia, Vancouver, Canada
    Nephrol Dial Transplant 27:iii104-10. 2012
    ..We sought to examine if streamlining medical care of complex patients (two or more conditions) is associated with similar, worse or improved outcomes using a randomized controlled study design...
  8. doi request reprint Incident isolated 1,25(OH)(2)D(3) deficiency is more common than 25(OH)D deficiency in CKD
    Adeera Levin
    BC Provincial Renal Agency, Vancouver, British Columbia, Canada
    J Nephrol 25:204-10. 2012
    ....
  9. doi request reprint Nondialysis chronic kidney disease in 2011: Progression, prediction, populations and possibilities
    Adeera Levin
    Division of Nephrology, Department of Medicine, St Paul s Hospital, University of British Columbia, 1081 Burrard Street, Room 6010 A, Vancouver, BC V6Z 1Y6, Canada
    Nat Rev Nephrol 8:70-2. 2012
    ....
  10. pmc Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury
    Ravindra L Mehta
    Department of Medicine, University of California San Diego Medical Center 8342, 200 W, Arbor Drive, San Diego, CA 92103, USA
    Crit Care 11:R31. 2007
    ..We describe an initiative to develop uniform standards for defining and classifying AKI and to establish a forum for multidisciplinary interaction to improve care for patients with or at risk for AKI...
  11. ncbi request reprint Prevalence of abnormal serum vitamin D, PTH, calcium, and phosphorus in patients with chronic kidney disease: results of the study to evaluate early kidney disease
    A Levin
    Department of Nephrology, University of British Columbia, Vancouver, BC, Canada
    Kidney Int 71:31-8. 2007
    ..As bone, cardiovascular disease, and mineral metabolite are correlated; further studies are necessary to determine the importance of these findings relative to outcomes...
  12. ncbi request reprint N-acetylcysteine reduces urinary albumin excretion following contrast administration: evidence of biological effect
    Adeera Levin
    Division of Nephrology, Room 6010, Providence Health Care Saint Paul s Hospital, University of British Columbia, 1081 Burrard Street, Vancouver V6Z 1Y6, BC, Canada
    Nephrol Dial Transplant 22:2520-4. 2007
    ....
  13. doi request reprint Low birth weight and nephron mass and their role in the progression of chronic kidney disease: a case report on identical twins with Alport disease
    Tasleem Rajan
    Department of Medicine, University of British Columbia, Vancouver, Canada
    Nephrol Dial Transplant 26:4136-9. 2011
    ..We suggest further studies and surveillance for this high-risk group of infants in order to gain additional insights into the impact of perinatal factors such as LBW...
  14. ncbi request reprint Haemoglobin at time of referral prior to dialysis predicts survival: an association of haemoglobin with long-term outcomes
    Adeera Levin
    Division of Nephrology, University of British Columbia, 1081 Burrard Street, Rm 6010A, Vancouver BC Canada V6Z1Y8
    Nephrol Dial Transplant 21:370-7. 2006
    ..Substantial variation in Hgb values exists at all GFR levels. These findings underscore the importance of evaluating Hgb at all GFR levels, and the need to study the impact of modification of Hgb at different GFR levels on survival...
  15. ncbi request reprint Cardiac disease in chronic kidney disease: current understandings and opportunities for change
    A Levin
    St Paul s Hospital, University of British Columbia, Vancouver, Canada
    Blood Purif 22:21-7. 2004
    ..This overview describes the current state of knowledge and emphasizes the interplay between CVD and CKD as two aspects of a set of pathophysiological processes, which impact on patient outcomes...
  16. ncbi request reprint Kidneys, hearts, hormones and immunomodulators: integrated understandings
    Adeera Levin
    University of British Columbia, St Paul s Hospital, Vancouver, Canada
    Blood Purif 24:46-50. 2006
    ....
  17. ncbi request reprint Executing change in the management of chronic kidney disease: perspectives on guidelines and practice
    Adeera Levin
    Nephrology Education and Research, St Paul s Hospital, 1081 Burrard Street, Room 6010A, Vancouver, BC V6Z 1Y6, Canada
    Med Clin North Am 89:701-9. 2005
    ..The systematic evaluation of all patients and incorporation of simplified definitions and classification systems should enhance the ability to improve the outcomes of patients with kidney disease irrespective of time of identification...
  18. ncbi request reprint The treatment of anemia in chronic kidney disease: understandings in 2006
    Adeera Levin
    Division of Nephrology, University of British Columbia, St Paul s Hospital, Vancouver, British Columbia, Canada
    Curr Opin Nephrol Hypertens 16:267-71. 2007
    ..It is important for clinical care to identify appropriate treatments and targets for hemoglobin. This review describes current understandings of the treatment of anemia using the most recent published articles...
  19. doi request reprint Variability and risk factors for kidney disease progression and death following attainment of stage 4 CKD in a referred cohort
    Adeera Levin
    Division of Nephrology, University of British Columbia, BC Provincial Renal Agency, Vancouver, British Columbia, Canada
    Am J Kidney Dis 52:661-71. 2008
    ..The objectives of this analysis are to describe the predictors of rapid progression of kidney disease and death in patients followed up by nephrologists...
  20. ncbi request reprint Canadian randomized trial of hemoglobin maintenance to prevent or delay left ventricular mass growth in patients with CKD
    Adeera Levin
    University of British Columbia, St Paul s Hospital, Vancouver, British Columbia, Canada
    Am J Kidney Dis 46:799-811. 2005
    ..Study design and sample size calculations were based on previously published Canadian data...
  21. ncbi request reprint Clinical epidemiology of cardiovascular disease in chronic kidney disease prior to dialysis
    Adeera Levin
    Department of Medicine, Division of Nephrology, University of British Columbia, Vancouver, Canada
    Semin Dial 16:101-5. 2003
    ..We identify the importance of well-conducted studies of patient groups with and without CVD, with and without CKD, in order to better understand the complex physiology so that treatment strategies can be appropriately applied...
  22. ncbi request reprint Cardiovascular disease in patients with chronic kidney disease: getting to the heart of the matter
    A Levin
    Division of Nephrology, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Kidney Dis 38:1398-407. 2001
    ..Further large-scale, observational studies as well as interventional studies are needed to more clearly understand the complex biology of cardiovascular and kidney disease progression...
  23. ncbi request reprint The relationship of haemoglobin level and survival: direct or indirect effects?
    Adeera Levin
    University of British Columbia, Vancouver, Canada
    Nephrol Dial Transplant 17:8-13. 2002
    ....
  24. ncbi request reprint Cardiovascular disease and the kidney. Tracking a killer in chronic kidney disease
    Adeera Levin
    Division of Nephrology, University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada
    Postgrad Med 111:53-60. 2002
    ..Finally, physicians should be careful to avoid therapeutic nihilism in patients with kidney disease; those at highest risk of CVD are likely to receive the greatest benefit from cardiovascular therapies...
  25. doi request reprint Acute kidney injury: toward an integrated understanding through development of a research agenda
    Adeera Levin
    Division of Nephrology UBC, St Pauls Hospital, Providence Wing, Room 6010A, 1160 Burrard Street, Vancouver BC, V6Z1Y8, Canada
    Clin J Am Soc Nephrol 3:862-3. 2008
  26. ncbi request reprint Cardiovascular disease in chronic renal insufficiency
    A Levin
    University of British Columbia, St Paul s Hospital, Vancouver, British Columbia, Canada
    Am J Kidney Dis 36:S24-30. 2000
    ..Long-term interventional studies are needed to determine costs, benefits, and risks of such strategies...
  27. doi request reprint Practice guidelines do improve patient outcomes: association or causation?
    A Levin
    Division of Nephrology, University of British Columbia, Vancouver, BC, Canada
    Blood Purif 26:67-72. 2008
    ..Rigorous evaluation of current implementation techniques and resultant impacts should be undertaken...
  28. ncbi request reprint Left ventricular mass index increase in early renal disease: impact of decline in hemoglobin
    A Levin
    Centre for Health Outcomes and Evaluation Sciences, St Paul s Hospital, Vancouver, Canada
    Am J Kidney Dis 34:125-34. 1999
    ..We defined the important modifiable risk factors. There remains a critical need to establish optimal therapeutic strategies and targets to improve clinical outcomes...
  29. ncbi request reprint Canadian survey of clinical status at dialysis initiation 1998-1999: a multicenter prospective survey
    B M Curtis
    Division of Nephrology, Memorial University of Newfoundland, Canada
    Clin Nephrol 58:282-8. 2002
    ..Our main objective was to improve the understanding of current Canadian nephrology practice between October 1998 and December 1999...
  30. ncbi request reprint Screening for renal disease using serum creatinine: who are we missing?
    L Duncan
    Division of Nephrology, Department of Medicine, St Paul s Hospital, University of British Columbia, Vancouver, BC, Canada V6Z 1Y6
    Nephrol Dial Transplant 16:1042-6. 2001
    ..This study was designed to estimate the prevalence of patients who have significantly reduced GFR as calculated by the Cockcroft-Gault (C-G) formula, but normal-range SCR:..
  31. ncbi request reprint The short- and long-term impact of multi-disciplinary clinics in addition to standard nephrology care on patient outcomes
    Bryan M Curtis
    Division of Nephrology, Patient Research Center, Memorial University of Newfoundland, Canada
    Nephrol Dial Transplant 20:147-54. 2005
    ..This two country case control study of incident dialysis patients evaluates the outcomes of patients exposed to formalized multi-disciplinary clinic (MDC) programmes vs standard nephrologist care...
  32. pmc Exploration of association of 1,25-OH2D3 with augmentation index, a composite measure of arterial stiffness
    Jason Andrade
    Department of Medicine, University of British Columbia, Saint Paul s Hospital, Vancouver, BC, Canada
    Clin J Am Soc Nephrol 3:1800-6. 2008
    ..Central arterial stiffness can be measured using noninvasive technologies, including augmentation index (AIx), a composite measure of arterial stiffness...
  33. ncbi request reprint Anaemia, cardiovascular disease and kidney disease: integrating new knowledge in 2002
    Lesley A Stevens
    University of British Columbia, Vancouver, Canada
    Curr Opin Nephrol Hypertens 12:133-8. 2003
    ..The present review assesses recent publications, from 2001 until the present, which address the relationship between cardiovascular disease (CVD) and anaemia in patients with chronic kidney disease...
  34. ncbi request reprint Current and future challenges in anaemia management
    A Levin
    University of British Columbia, Vancouver, Canada
    Nephrol Dial Transplant 20:vi1-2. 2005
  35. ncbi request reprint Sex, haemoglobin and kidney disease: new perspectives
    J A Duncan
    Division of Nephrology, University of British Columbia, Vancouver, Canada
    Eur J Clin Invest 35:52-7. 2005
    ..The value of a new perspective on haemoglobin and gender in kidney disease is important from both a physiological and an economical perspective...
  36. ncbi request reprint Prevalence of cardiovascular damage in early renal disease
    A Levin
    University of British Columbia, Renal Insufficiency Clinic, Vancouver, Canada
    Nephrol Dial Transplant 16:7-11. 2001
    ..Recognizing modifiable risk factors and addressing them early in the course of renal disease will facilitate the improvement of patient outcomes...
  37. pmc Identifying and slowing progressive chronic renal failure
    B Curtis
    Division of Nephrology, St Paul's Hospital, Vancouver
    Can Fam Physician 47:2512-8. 2001
    ..CONCLUSION: Family physicians play an important role in recognizing patients with potential for renal failure, in demonstrating progressive chronic renal failure, and in initiating therapy early to improve outcomes...
  38. doi request reprint The prevalence of hematologic and metabolic abnormalities during chronic kidney disease stages in different ethnic groups
    S J Barbour
    Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Kidney Int 74:108-14. 2008
    ..Hence, it appears that South Asians and Oriental Asians have more laboratory abnormalities compared with Caucasians at most levels of eGFR...
  39. doi request reprint Early initiation of phosphate lowering dietary therapy in non-dialysis chronic kidney disease: a critical review
    M K Sigrist
    University of British Columbia, St Paul s Hospital, Vancouver, Canada
    J Ren Care 35:71-8. 2009
    ....
  40. ncbi request reprint Analysis of cardiovascular disease and kidney outcomes in multidisciplinary chronic kidney disease clinics: complex disease requires complex care models
    Paul Komenda
    Division of Nephrology, University of British Columbia, Vancouver, British Columbia, Canada
    Curr Opin Nephrol Hypertens 15:61-6. 2006
    ..Specifically we examine the rationale and outcomes of those seen in multidisciplinary clinics...
  41. ncbi request reprint Stage of chronic kidney disease predicts seroconversion after hepatitis B immunization: earlier is better
    Gerald DaRoza
    Division of Nephrology, Kidney Function Clinic, Canada
    Am J Kidney Dis 42:1184-92. 2003
    ..This prospective cohort study evaluated factors impacting on the effectiveness of a vaccination program before dialysis therapy initiation, including level of kidney function...
  42. doi request reprint Incidental atherosclerotic renal artery stenosis in patients undergoing elective coronary angiography: are these lesions significant?
    M E Schachter
    Division of Nephrology, University of British Columbia, St Paul s Hospital, 1081 Burrard Street, Vancouver, B C, Canada
    Am J Nephrol 29:434-9. 2009
    ..The present study sought to describe renal perfusion using non-captopril (baseline) nuclear renograms in patients with iARAS, and to determine characteristics associated with a positive captopril renogram...
  43. ncbi request reprint Obstacles to residents' conducting research and predictors of publication
    S Gill
    Department of Medicine, University of British Columbia, Vancouver, BC, Canada
    Acad Med 76:477. 2001
    ..Insufficient time was the key obstacle to completing research. Residents with previous research experience, senior residents, and men were more likely to publish...
  44. doi request reprint Pulse wave velocity measurements are reproducible in multiple trained observers: a short report
    M K Sigrist
    St Paul s Hospital, Vancouver, B C, Canada
    Nephron Clin Pract 116:c60-4. 2010
    ..The aim of this study was to investigate the ability of 4 observers to acquire reproducible PWV and pulse wave analysis (PWA) measurements after a 6-week training period...
  45. ncbi request reprint Outcomes after percutaneous coronary interventions in patients with CKD: improved outcome in the stenting era
    Caroline Stigant
    Department of Health Care and Epidemiology, St Paul s Hospital, University of British Columbia, Vancouver, BC, Canada
    Am J Kidney Dis 45:1002-9. 2005
    ..The benefit of stents in high-risk patients normally excluded from clinical trials has not been well studied. Outcomes after PCIs in patients with chronic kidney disease (CKD) before and after widespread use of stents were compared...
  46. doi request reprint Matrix metalloproteinase-2 and -9 exacerbate arterial stiffening and angiogenesis in diabetes and chronic kidney disease
    Ada W Y Chung
    Department of Cardiovascular Science, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada V5Z 4H4
    Cardiovasc Res 84:494-504. 2009
    ..We hypothesized that MMP-2 and -9 were up-regulated in the arterial vasculature from CKD patients with diabetes, compared with those without diabetes...
  47. doi request reprint Incidental atherosclerotic renal artery stenosis diagnosed at cardiac catheterization: no difference in kidney function with or without stenting
    Nadia Zalunardo
    Division of Nephrology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Nephrol 28:921-8. 2008
    ....
  48. ncbi request reprint The evaluation of a successful home hemodialysis program: establishing a prospective framework for quality
    P Komenda
    Department of Medicine, Section of Nephrology, St Boniface General Hospital, University of Manitoba, Manitoba Renal Program, Winnipeg, MB, Canada
    Clin Nephrol 71:467-74. 2009
    ..This will allow for the assessment of numerous outcomes on a global scale for this state-of-the art dialysis modality in the form of a multidimensional programmatic evaluation...
  49. ncbi request reprint Evaluation of predictive formulae for glomerular filtration rate for carboplatin dosing in gynecological malignancies
    Mario L de Lemos
    Provincial Drug Information Coordinator, Provincial Systemic Therapy Program, British Columbia Cancer Agency, 600 West 10th Avenue, Vancouver, BC, V5Z 4E6, Canada
    Gynecol Oncol 103:1063-9. 2006
    ..The MDRD formula has been shown to be more accurate in non-cancer patients with chronic renal disease. We compared the accuracy of these formulae for dosing carboplatin in patients with gynecological cancers...
  50. doi request reprint A comparison of the predictive performance of different methods of kidney function estimation in a well-characterized HIV-infected population
    Katherine Barraclough
    Division of Nephrology, University of British Columbia, Vancouver, B C, Canada
    Nephron Clin Pract 111:c39-48. 2009
    ..Glomerular filtration rate (GFR) estimation equations have never been validated in the HIV population. This pilot study aimed to compare all currently available methods of kidney function assessment with nuclear GFR in HIV-infected adults...
  51. ncbi request reprint An unusual case of acute kidney injury due to vancomycin lessons learnt from reliance on eGFR
    Katherine Barraclough
    Department of Nephrology, St Paul s Hospital, Vancouver, British Colombia, V6Z1Y6, Canada
    Nephrol Dial Transplant 22:2391-4. 2007
    ..We support ongoing efforts to develop or refine equations for specific unique and easily identifiable populations...
  52. ncbi request reprint Renal safety of 1-hour pamidronate infusion for breast cancer and multiple myeloma patients: comparison between clinical trials and population-based database
    Mario L de Lemos
    Provincial Systemic Therapy Program, British Columbia Cancer Agency, Vancouver, BC, Canada
    J Oncol Pharm Pract 12:193-9. 2006
    ..The American Society of Clinical Oncology recommends infusion of pamidronate over 2 hours to avoid renal deterioration, although there are data to suggest that 1-hour infusions may be safe...
  53. doi request reprint Analysis of multidisciplinary care models and interface with primary care in management of chronic kidney disease
    Monica Beaulieu
    Division of Nephrology, University of British Columbia, Vancouver, British Columbia, Canada
    Semin Nephrol 29:467-74. 2009
    ....
  54. doi request reprint Differential microvasculature dysfunction in living kidney donor transplant recipients: nondialyzed versus dialyzed chronic kidney disease patients
    Ada W Y Chung
    Department of Cardiovascular Science, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada
    J Vasc Res 47:128-38. 2010
    ..282, p = 0.01). In conclusion, we have uniquely demonstrated differential microvasculature dysfunction between nondialyzed and dialyzed CKD patients...
  55. doi request reprint Systematic review of evidence for the use of intradialytic parenteral nutrition in malnourished hemodialysis patients
    Mhairi K Sigrist
    Department of Nephrology, University of British Columbia, St Paul s Hospital, Vancouver, British Columbia, Canada
    J Ren Nutr 20:1-7. 2010
    ..This study systematically reviews the current literature, to assess whether IDPN improves survival, quality of life, or nutritional status in those receiving maintenance HD...
  56. ncbi request reprint A randomized controlled trial of intravenous N-acetylcysteine for the prevention of contrast-induced nephropathy after cardiac catheterization: lack of effect
    John G Webb
    Division of Cardiology, Pharmacy Department, St Paul s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    Am Heart J 148:422-9. 2004
    ..The objective of this study was to evaluate, in a blinded, randomized, placebo-controlled fashion, whether intravenous NAC reduced CIN in the setting of cardiac catheterization in patients with preexisting renal insufficiency...
  57. doi request reprint Vitamin D and parathyroid hormone in general populations: understandings in 2009 and applications to chronic kidney disease
    Manraj Johal
    Division of Nephrology, University of British Columbia, Vancouver BC, Canada V6Z 1Y8
    Clin J Am Soc Nephrol 4:1508-14. 2009
    ..Some recommendations for pragmatic approaches and study design are suggested...
  58. ncbi request reprint Cardiovascular events and investigation in patients who are awaiting cadaveric kidney transplantation
    John S Gill
    Division of Nephrology, University of British Columbia, St Paul s Hospital, Providence 6a, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
    J Am Soc Nephrol 16:808-16. 2005
    ..Initial cardiac investigations have limited value in guiding the timing of patient reevaluation after wait-listing. Periodic surveillance cardiac investigation after wait-listing may be unnecessary and requires further study...
  59. ncbi request reprint Should hemoglobin be normalized in patients with chronic kidney disease?
    Lesley Stevens
    Department of Medicine, Nephrology Division, University of British Columbia, Vancouver, British Columbia, Canada
    Semin Dial 15:8-13. 2002
    ..However, the effects of therapy will be most impressive when accompanied by the optimal care of all hemodynamic and metabolic abnormalities that are associated with CKD...
  60. ncbi request reprint Central vein stenosis: a common problem in patients on hemodialysis
    Jennifer M MacRae
    Division of Nephrology, University of British Columbia, Vancouver, Canada
    ASAIO J 51:77-81. 2005
    ..Thus further studies should attempt to determine the true incidence of this problem and ultimately address the optimal treatment strategies...
  61. doi request reprint Outcomes of vascular access creation prior to dialysis: building the case for early referral
    Catherine L Weber
    Division of Nephrology, Department of Medicine, University British Columbia, Vancouver, British Columbia, Canada
    ASAIO J 55:355-60. 2009
    ..001). In conclusion, the success rate of early AVF creation is reasonable and complications when identified can be remedied without the need for a catheter, thus ultimately maximizing the use of AVF in dialysis patients...
  62. doi request reprint Elevated osteoprotegerin is associated with all-cause mortality in CKD stage 4 and 5 patients in addition to vascular calcification
    Mhairi K Sigrist
    School of Graduate Entry Medicine and Health, The University of Nottingham, Derby, UK
    Nephrol Dial Transplant 24:3157-62. 2009
    ..The mechanisms of vascular damage are not fully understood. The objective of this study was to prospectively investigate the importance of novel mediators of vascular damage, in conjunction with vascular calcification (VC), on survival...
  63. doi request reprint Upregulation of matrix metalloproteinase-2 in the arterial vasculature contributes to stiffening and vasomotor dysfunction in patients with chronic kidney disease
    Ada W Y Chung
    Department of Cardiovascular Science, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
    Circulation 120:792-801. 2009
    ....
  64. pmc Chronic kidney disease, heart failure and anemia
    Sean A Virani
    University of British Columbia, Vancouver, British Columbia
    Can J Cardiol 24:22B-4B. 2008
    ..Future research in this arena must focus on the optimal dose of erythropoietin administered to hemoglobin level achieved that will result in improved cardiovascular outcomes for patients with heart failure and kidney disease...
  65. ncbi request reprint N-acetylcysteine for prevention of radiographic contrast material-induced nephropathy: is the intravenous route best?
    Stephen J Shalansky
    Pharmacy Department, St Paul s Hospital, and Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada
    Pharmacotherapy 25:1095-103. 2005
    ....
  66. ncbi request reprint The profile of cardiac patients with renal artery stenosis
    Christopher E Buller
    Department of Medicine, Division of Cardiology, University of British Columbia, Vancouver, Canada
    J Am Coll Cardiol 43:1606-13. 2004
    ....
  67. doi request reprint Nephrogenic systemic fibrosis: the story unfolds
    D Prchal
    University of British Columbia, Department of Medicine, Division of Nephrology, St Paul s Hospital, Vancouver, British Columbia, Canada
    Kidney Int 73:1335-7. 2008
    ..The purpose of this Commentary is to briefly summarize the current knowledge of nephrogenic systemic fibrosis in order to promote better understanding of the complexity of chronic kidney disease and its associated conditions...
  68. doi request reprint Progressive kidney disease in three sisters with elevated lipoprotein(a)
    J Staples
    University of British Columbia, Room 6010A 1081 Burrard, Vancouver BC V6Z 1Y8, Canada
    Nephrol Dial Transplant 23:1756-9. 2008
  69. doi request reprint Increased matrix metalloproteinase 2 activity in the human internal mammary artery is associated with ageing, hypertension, diabetes and kidney dysfunction
    A W Chung
    The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, University of British Columbia, Vancouver, BC, Canada
    J Vasc Res 45:357-62. 2008
    ..It is the first report suggesting that MMP-2 in the arterial vasculature could be the possible mediator crucial in linking the progression of kidney function to cardiovascular disease...
  70. ncbi request reprint Coronary artery disease in chronic kidney disease patients: assessing the evidence for diagnosis, screening and revascularization
    Jacqueline Saw
    Department of Medicine, Vancouver General Hospital, British Columbia
    Can J Cardiol 20:807-13. 2004
    ..The current diagnostic and revascularization strategy for CAD in CKD patients is discussed, highlighting current controversies that warrant further investigation...
  71. ncbi request reprint Short and long alteplase dwells in dysfunctional hemodialysis catheters
    Jennifer Marie Macrae
    Division of Nephrology, St Paul s Hospital, Univeristy of British Columbia, Vancouver, British Columbia, Canada
    Hemodial Int 9:189-95. 2005
    ..The purpose of this study was to determine if TPA dwell time affects short- or long-term catheter patency rates...
  72. ncbi request reprint C-reactive protein levels in patients on maintenance hemodialysis: reliability and reflection on the utility of single measurements
    Caroline E Stigant
    Kidney Foundation of Canada Research Fellow, Division of Nephrology, University of British Columbia, British Columbia, Canada
    Int Urol Nephrol 37:133-40. 2005
    ..We prospectively obtained multiple CRP values in stable patients, hypothesizing that values would remain stable in the absence of disease and that a single CRP value would be a reliable marker of risk...
  73. ncbi request reprint Barriers to blood pressure control and angiotensin enzyme inhibitor use in Canadian patients with chronic renal insufficiency
    Marcello Tonelli
    Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Nephrol Dial Transplant 17:1426-33. 2002
    ..We designed this study to describe the use of these therapeutic strategies, and to investigate barriers to their implementation...
  74. pmc Coronary artery calcification scores in patients with chronic kidney disease prior to dialysis: reliability as a trial outcome measure
    Katherine A Barraclough
    Division of Nephrology, University of British Columbia, Vancouver, British Columbia, Canada
    Nephrol Dial Transplant 23:3199-205. 2008
    ....
  75. ncbi request reprint Attitudes of Canadian nephrologists toward multidisciplinary team-based CKD clinic care
    David C Mendelssohn
    Department of Nephrology, Humber River Regional Hospital, University of Toronto, Weston, Canada
    Am J Kidney Dis 47:277-84. 2006
    ..Although evidence supporting the advantages of multidisciplinary team-based chronic kidney disease (CKD) care is not well developed, many groups are advocating increased availability of this model...
  76. ncbi request reprint Collapsing glomerulopathy coexisting with membranous glomerulonephritis in native kidney biopsies: a report of 3 HIV-negative patients
    Ali Al-Shamari
    Division of Nephrology, University of British Columbia, Vancouver, BC, Canada
    Am J Kidney Dis 42:591-5. 2003
    ..We report 3 HIV-negative patients (2 men, 1 woman) who developed nephrotic syndrome secondary to MGN complicated by CG, with relatively rapid disease progression despite aggressive therapy...
  77. ncbi request reprint Use of GFR equations to adjust drug doses in an elderly multi-ethnic group--a cautionary tale
    Jagbir Gill
    Division of Nephrology, UBC, Centre for Health Evaluation and Outcome Sciences, Vancouver, BC, Canada
    Nephrol Dial Transplant 22:2894-9. 2007
    ..A cross-sectional study of long-term care facility patients was conducted to demonstrate the impact of the use of different formulae in the elderly for the purposes of medication dosing...
  78. ncbi request reprint The economics of home nocturnal hemodialysis: how should we cost the benefits?
    P Komenda
    Department of Medicine, Division of Nephrology, University of British Columbia
    Clin Nephrol 68:151-8. 2007
    ..This information will assist decision-makers in determining whether to make HNHD more widely available...
  79. ncbi request reprint Conservative outpatient renoprotective protocol in patients with low GFR undergoing contrast angiography: a case series
    Paul Komenda
    Department of Medicine, Division of Nephrology, St Paul s Hospital, Division of Nephrology, University of British Columbia, 1081 Burrard Street, Providence Wing RM 6010A, Vancouver, BC, Canada
    Clin Exp Nephrol 11:209-13. 2007
    ..For this reason potentially life-saving procedures such as angiography are sometimes withheld or delayed...
  80. doi request reprint Outcomes of a provincial home haemodialysis programme--a two-year experience: establishing benchmarks for programme evaluation
    Paul Komenda
    Division of Nephrology, University of British Columbia, Vancouver, British Columbia, Canada
    Nephrol Dial Transplant 23:2647-52. 2008
    ..HHD programmes have reported successful outcomes with respect to patients' well-being, haemodynamic stability and improvement of clinical and biochemical parameters in small selected groups of patients...
  81. pmc Nephrology: 4. Strategies for the care of adults with chronic kidney disease
    Caroline Stigant
    University of British Columbia, Vancouver, BC
    CMAJ 168:1553-60. 2003
  82. ncbi request reprint Preanalytical influences on DPC IMMULITE 2000 intact PTH assays of plasma and serum from dialysis patients
    Daniel T Holmes
    Department of Pathology and Laboratory Medicine, St Paul s Hospital, Vancouver, Canada
    Clin Chem 51:915-7. 2005
  83. doi request reprint Variability of hepatitis B testing in British Columbian ESRD patients: the case to focus on implementation of guidelines
    Monica Beaulieu
    Division of Nephrology, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Kidney Dis 52:939-46. 2008
    ..Hepatitis B virus (HBV) immunization protocols are routinely followed in dialysis units. Recommendations for retesting and booster dose administration are variable and less well known...
  84. ncbi request reprint Anemia and the heart in chronic kidney disease
    Nadia Zalunardo
    Kidney Foundation of Canada, Clinical Investigator Program, Vancouver, British Columbia, Canada
    Semin Nephrol 26:290-5. 2006
    ....
  85. doi request reprint Utility and limitations of a multicenter nocturnal home hemodialysis cohort
    Robert P Pauly
    Department of Medicine, Division of Nephrology, University of Alberta, Edmonton, Alberta, Canada
    Clin J Am Soc Nephrol 3:1846-51. 2008
    ....
  86. ncbi request reprint Identification of patients and risk factors in chronic kidney disease--evaluating risk factors and therapeutic strategies
    A Levin
    Division of Nephrology, St Paul's Hospital, University of British Columbia, 1081 Burrard Street, Vancouver, British Columbia V6Z 1Y6, Canada
    Nephrol Dial Transplant 16:57-60. 2001
    ..However, further evidence-based demonstrations of success are required, showing benefit to both patients and health care systems...
  87. ncbi request reprint Management of membranoproliferative glomerulonephritis: evidence-based recommendations
    A Levin
    Division of Nephrology, University of British Columbia, St Paul s Hospital, Vancouver, Canada
    Kidney Int Suppl 70:S41-6. 1999
    ..Again, if no benefits are seen, the treatment should be stopped. Attention to factors known to delay the progression of renal decline and close follow-up should be part of the treatment plan (grades B and C)...
  88. doi request reprint The cost of starting and maintaining a large home hemodialysis program
    Paul Komenda
    British Columbia Provincial Renal Agency, Vancouver, Canada
    Kidney Int 77:1039-45. 2010
    ..Consideration of hidden costs is important for administrators and planners to take into account when designing budgets for home hemodialysis...
  89. ncbi request reprint Successful reintroduction of a different erythropoiesis-stimulating agent after pure red cell aplasia: relapse after successful therapy with prednisone
    Jason Andrade
    Department of Medicine, University of British Columbia, St Paul s Hospital, Vancouver BC, Canada
    Nephrol Dial Transplant 20:2548-51. 2005
    ..It appears that there may be problems associated with discontinuation of immunosuppressive therapy in the presence of sustained erythropoiesis-stimulating agent therapy in those in whom the condition has occurred previously...
  90. ncbi request reprint Prognostic value of troponin T and I among asymptomatic patients with end-stage renal disease: a meta-analysis
    Nadia A Khan
    Division of Internal Medicine, University of British Columbia, Canada
    Circulation 112:3088-96. 2005
    ....
  91. ncbi request reprint Kidney function and mortality among patients with left ventricular systolic dysfunction
    Nadia A Khan
    Division of Internal Medicine, University of British Columbia, Department of Medicine, 620 B, 1081 Burrard Street, Vancouver, BC, Canada, V6Z 1Y6
    J Am Soc Nephrol 17:244-53. 2006
    ..Rate of decline in kidney function is a strong predictor of increased mortality in this population, independent of worsening heart failure and baseline kidney function...
  92. ncbi request reprint Surveillance cultures of tunneled cuffed catheter exit sites in chronic hemodialysis patients are of no benefit
    Debbie Rosenbaum
    Division of Nephrology, St Paul s Hospital, University of British Columbia, Vancouver, BC, Canada
    Hemodial Int 10:365-70. 2006
    ..16.7%, p > 0.05). The strategy of treating positive surveillance cultures is not beneficial. Positive Ssc do not predict the occurrence of catheter-related infection, and treatment of these cultures may lead to increased infection rates...
  93. pmc Screening for Fabry disease in patients with chronic kidney disease: limitations of plasma alpha-galactosidase assay as a screening test
    Jason Andrade
    Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Clin J Am Soc Nephrol 3:139-45. 2008
    ..This study sought to determine the prevalence of Fabry disease in a multiethnic male chronic kidney disease population, involving dialysis-dependent, non-dialysis-dependent, and transplant patients...
  94. doi request reprint Urinary NGAL levels before and after coronary angiography: a complex story
    Catherine L Weber
    Division of Nephrology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Nephrol Dial Transplant 26:3207-11. 2011
    ..We describe urinary neutrophil gelatinase-associated lipocalin (uNGAL) values in association with clinical characteristics and urinary parameters in adults undergoing coronary angiography...
  95. doi request reprint Implementing a home haemodialysis programme without adversely affecting a peritoneal dialysis programme
    Michael Copland
    British Columbia Renal Agency, Division of Nephrology, University of British Columbia, Vancouver, BC V5Z 1M9, Canada
    Nephrol Dial Transplant 24:2546-50. 2009
    ..This study attempts to look at the impact of a new home haemodialysis programme on an existing peritoneal dialysis programme in the province of British Columbia...
  96. ncbi request reprint National Kidney Foundation practice guidelines for chronic kidney disease: evaluation, classification, and stratification
    Andrew S Levey
    Tufts New England Medical Center and Tufts University School of Medicine, Boston, Massachusetts, USA
    Ann Intern Med 139:137-47. 2003
    ..Because of the high prevalence of early stages of chronic kidney disease in the general population (approximately 11% of adults), this information is particularly important for general internists and specialists...
  97. ncbi request reprint Calcium, phosphate, and parathyroid hormone levels in combination and as a function of dialysis duration predict mortality: evidence for the complexity of the association between mineral metabolism and outcomes
    Lesley A Stevens
    Division of Nephrology, New England Medical Centre, Boston, Massachusetts, USA
    J Am Soc Nephrol 15:770-9. 2004
    ..In so doing, the complex interaction of time and MM can begin to be understand. Further exploration is required...
  98. ncbi request reprint Effects of early and late intervention with epoetin alpha on left ventricular mass among patients with chronic kidney disease (stage 3 or 4): results of a randomized clinical trial
    Simon D Roger
    Department of Renal Medicine, Gosford Hospital, Gosford, Australia
    J Am Soc Nephrol 15:148-56. 2004
    ..The maintenance of [Hb] above 100 g/L for many patients in group B might have been attributable to the relative preservation of renal function...
  99. ncbi request reprint The advantage of a uniform terminology and staging system for chronic kidney disease (CKD)
    Adeera Levin
    Nephrol Dial Transplant 18:1446-51. 2003
  100. ncbi request reprint The role of anaemia in the genesis of cardiac abnormalities in patients with chronic kidney disease
    Adeera Levin
    Nephrol Dial Transplant 17:207-10. 2002
  101. pmc Slowing the progression of chronic renal insufficiency
    Marcello Tonelli
    Department of Medicine, Dalhousie University, Halifax, NS
    CMAJ 166:906-7. 2002