Celine M Levesque

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. pmc The chromosomal mazEF locus of Streptococcus mutans encodes a functional type II toxin-antitoxin addiction system
    Mohammad Adnan Syed
    Dental Research Institute, Faculty of Dentistry, University of Toronto, Toronto, Ontario M5G 1G6, Canada
    J Bacteriol 193:1122-30. 2011
  2. pmc Systemic inactivation and phenotypic characterization of two-component systems in expression of Streptococcus mutans virulence properties
    C M Lévesque
    Dental Research Institute, Faculty of Dentistry, University of Toronto, Toronto, ON, Canada
    Lett Appl Microbiol 45:398-404. 2007
  3. pmc TcyR regulates L-cystine uptake via the TcyABC transporter in Streptococcus mutans
    Jennifer Kim
    Dental Research Institute, University of Toronto, Toronto, ON, Canada
    FEMS Microbiol Lett 328:114-21. 2012
  4. pmc Characterization of a Streptococcus mutans intergenic region containing a small toxic peptide and its cis-encoded antisense small RNA antitoxin
    Stephanie Koyanagi
    Dental Research Institute, Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 8:e54291. 2013
  5. pmc Involvement of sortase anchoring of cell wall proteins in biofilm formation by Streptococcus mutans
    Celine M Levesque
    Oral Microbiology, Faculty of Dentistry, University of Toronto, 124 Edward Street, Toronto, Ontario, Canada M5G 1G6
    Infect Immun 73:3773-7. 2005
  6. doi request reprint The involvement of the pyruvate dehydrogenase E1alpha subunit, in Streptococcus mutans acid tolerance
    Bryan Korithoski
    Dental Research Institute, University of Toronto, Toronto, ON, Canada
    FEMS Microbiol Lett 289:13-9. 2008
  7. pmc Cell death in Streptococcus mutans biofilms: a link between CSP and extracellular DNA
    Julie A Perry
    Dental Research Institute, Faculty of Dentistry, University of Toronto, 124 Edward Street, Toronto, Ontario, Canada
    FEMS Microbiol Lett 299:261-6. 2009
  8. pmc Regulation of the competence pathway as a novel role associated with a streptococcal bacteriocin
    Delphine Dufour
    Dental Research Institute, Faculty of Dentistry, University of Toronto, 124 Edward St, Toronto, Ontario M5G 1G6, Canada
    J Bacteriol 193:6552-9. 2011
  9. pmc A stress-inducible quorum-sensing peptide mediates the formation of persister cells with noninherited multidrug tolerance
    Vincent Leung
    Dental Research Institute, Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada
    J Bacteriol 194:2265-74. 2012
  10. pmc The LiaFSR system regulates the cell envelope stress response in Streptococcus mutans
    Prashanth Suntharalingam
    Dental Research Institute, Faculty of Dentistry, University of Toronto, 124 Edward St, Toronto, Ontario M5G1G6, Canada
    J Bacteriol 191:2973-84. 2009

Collaborators

Detail Information

Publications20

  1. pmc The chromosomal mazEF locus of Streptococcus mutans encodes a functional type II toxin-antitoxin addiction system
    Mohammad Adnan Syed
    Dental Research Institute, Faculty of Dentistry, University of Toronto, Toronto, Ontario M5G 1G6, Canada
    J Bacteriol 193:1122-30. 2011
    ..Our results suggest that the MazEF TA module might represent a cell growth modulator facilitating the persistence of S. mutans under the harsh conditions of the oral cavity...
  2. pmc Systemic inactivation and phenotypic characterization of two-component systems in expression of Streptococcus mutans virulence properties
    C M Lévesque
    Dental Research Institute, Faculty of Dentistry, University of Toronto, Toronto, ON, Canada
    Lett Appl Microbiol 45:398-404. 2007
    ..To assess potential function of each two-component signal transduction system in the expression of Streptococcus mutans virulence properties...
  3. pmc TcyR regulates L-cystine uptake via the TcyABC transporter in Streptococcus mutans
    Jennifer Kim
    Dental Research Institute, University of Toronto, Toronto, ON, Canada
    FEMS Microbiol Lett 328:114-21. 2012
    ..Our study enhances the understanding of l-cystine uptake in S. mutans, which allows survival and persistence of this pathogen in the oral biofilm...
  4. pmc Characterization of a Streptococcus mutans intergenic region containing a small toxic peptide and its cis-encoded antisense small RNA antitoxin
    Stephanie Koyanagi
    Dental Research Institute, Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 8:e54291. 2013
    ..In contrast, mild-overproduction of Fst-Sm/srSm type I TA system decreases the levels of persister cells tolerant to bacterial cell wall synthesis inhibitors...
  5. pmc Involvement of sortase anchoring of cell wall proteins in biofilm formation by Streptococcus mutans
    Celine M Levesque
    Oral Microbiology, Faculty of Dentistry, University of Toronto, 124 Edward Street, Toronto, Ontario, Canada M5G 1G6
    Infect Immun 73:3773-7. 2005
    ..Genes encoding three putative sortase-dependent proteins were also found to be up-regulated in biofilms versus planktonic cells and mutations in these genes resulted in reduced biofilm biomass...
  6. doi request reprint The involvement of the pyruvate dehydrogenase E1alpha subunit, in Streptococcus mutans acid tolerance
    Bryan Korithoski
    Dental Research Institute, University of Toronto, Toronto, ON, Canada
    FEMS Microbiol Lett 289:13-9. 2008
    ..This study demonstrated that in S. mutans, pdhA expression responds to conditions conducive to heterofermentation and deletion of pdhA resulted in decreased aciduricity...
  7. pmc Cell death in Streptococcus mutans biofilms: a link between CSP and extracellular DNA
    Julie A Perry
    Dental Research Institute, Faculty of Dentistry, University of Toronto, 124 Edward Street, Toronto, Ontario, Canada
    FEMS Microbiol Lett 299:261-6. 2009
    ..mutans biofilm formation through the release of chromosomal DNA into the extracellular matrix, providing a long sought-after mechanistic explanation for the role of CSP in S. mutans biofilm formation...
  8. pmc Regulation of the competence pathway as a novel role associated with a streptococcal bacteriocin
    Delphine Dufour
    Dental Research Institute, Faculty of Dentistry, University of Toronto, 124 Edward St, Toronto, Ontario M5G 1G6, Canada
    J Bacteriol 193:6552-9. 2011
    ..Our data suggest that besides its role in cell lysis, the S. mutans CipB bacteriocin also functions as a peptide regulator for the transcriptional control of the competence regulon...
  9. pmc A stress-inducible quorum-sensing peptide mediates the formation of persister cells with noninherited multidrug tolerance
    Vincent Leung
    Dental Research Institute, Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada
    J Bacteriol 194:2265-74. 2012
    ..To the best of our knowledge, this is the first study reporting the induction of bacterial persistence using a quorum-sensing regulatory system...
  10. pmc The LiaFSR system regulates the cell envelope stress response in Streptococcus mutans
    Prashanth Suntharalingam
    Dental Research Institute, Faculty of Dentistry, University of Toronto, 124 Edward St, Toronto, Ontario M5G1G6, Canada
    J Bacteriol 191:2973-84. 2009
    ..While LiaF appears to be an integral component of the LiaSR signaling cascade, taken collectively, we report a novel role for LiaFSR in sensing cell envelope stress and preserving envelope integrity in S. mutans...
  11. pmc Cell death of Streptococcus mutans induced by a quorum-sensing peptide occurs via a conserved streptococcal autolysin
    Delphine Dufour
    Dental Research Institute, Faculty of Dentistry, University of Toronto, Ontario, Canada
    J Bacteriol 195:105-14. 2013
    ..mutans induced by its quorum-sensing CSP pheromone may represent a kind of altruistic act that provides a way for the species to survive environmental stresses at the expense of some of its cells...
  12. doi request reprint Chromosomal bacterial type II toxin-antitoxin systems
    Mohammad Adnan Syed
    Dental Research Institute, Faculty of Dentistry, University of Toronto, 124 Edward Street, Toronto, ON M5G 1G6, Canada
    Can J Microbiol 58:553-62. 2012
    ..This review describes the currently known type II toxins and their characteristics. The different hypotheses that have been proposed to explain their role in bacterial physiology are also discussed...
  13. doi request reprint Identification of a novel adhesin involved in acid-induced adhesion of enterohaemorrhagic Escherichia coli O157 : H7
    Frances Chingcuanco
    Department of Chemistry and Biology, Ryerson University, Toronto, ON, Canada
    Microbiology 158:2399-407. 2012
    ....
  14. pmc Microbial biofilm proliferation within sealer-root dentin interfaces is affected by sealer type and aging period
    Karina A Roth
    Discipline of Endodontics, University of Toronto, Toronto, Ontario, Canada
    J Endod 38:1253-6. 2012
    ..The objective of this study was to assess biofilm proliferation within the sealer-dentin interfaces of 2 methacrylate resin-based systems, self-etch (SE) and total-etch (TE), and an epoxy resin-based sealer (EP), aged for up to 6 months...
  15. doi request reprint Bacterial behaviors associated with the quorum-sensing peptide pheromone ('alarmone') in streptococci
    Delphine Dufour
    Dental Research Institute, Faculty of Dentistry, University of Toronto, 124 Edward St, Room 454B, Toronto, ON, M5G 1G6, Canada
    Future Microbiol 8:593-605. 2013
    ..Using a small quorum-sensing peptide pheromone acting as a stress-inducible 'alarmone', oral streptococci synchronize the gene expression of a specific group of cells to coordinate important biological activities...
  16. pmc Peptide alarmone signalling triggers an auto-active bacteriocin necessary for genetic competence
    Julie A Perry
    Dental Research Institute, Faculty of Dentistry, University of Toronto, Toronto, ON, Canada
    Mol Microbiol 72:905-17. 2009
    ..The role of the lytic response in S. mutans competence is also discussed. Together, these findings reveal a novel autolytic pathway in S. mutans which may be involved in the dissemination of fitness-enhancing genes in the oral biofilm...
  17. pmc Involvement of the detoxifying enzyme lactoylglutathione lyase in Streptococcus mutans aciduricity
    Bryan Korithoski
    Dental Research Institute, University of Toronto, 124 Edward St, Toronto, Ontario, Canada M5G 1G6
    J Bacteriol 189:7586-92. 2007
    ..5-fold) and following acid adaptation (approximately 2-fold). This study demonstrates that in S. mutans, LGL functions in the detoxification of methylglyoxal, resulting in increased aciduricity...
  18. pmc Cell density modulates acid adaptation in Streptococcus mutans: implications for survival in biofilms
    Y H Li
    Dental Research Institute, University of Toronto, 124 Edward St, Toronto, Ontario M5G 1G6, Canada
    J Bacteriol 183:6875-84. 2001
    ..This study demonstrated that cell density and biofilm growth mode modulated acid adaptation in S. mutans, suggesting that optimal development of acid adaptation in this organism involves both low pH induction and cell-cell communication...
  19. pmc Natural genetic transformation of Streptococcus mutans growing in biofilms
    Y H Li
    Dental Research Institute, University of Toronto, Toronto, Ontario, Canada M5G 1G6
    J Bacteriol 183:897-908. 2001
    ..This work demonstrated that a peptide pheromone system controls genetic competence in S. mutans and that the system functions optimally when the cells are living in actively growing biofilms...
  20. pmc uvrA is an acid-inducible gene involved in the adaptive response to low pH in Streptococcus mutans
    M N Hanna
    Dental Research Institute, University of Toronto, Toronto, Ontario, Canada M5G 1G6
    J Bacteriol 183:5964-73. 2001
    ..Here we suggest that uvrA and the nucleotide excision repair pathway are involved in the repair of acid-induced DNA damage and are associated with successful adaptation of S. mutans to low pH...