Peter C K Leung

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. Chang H, Qiao J, Leung P. Oocyte-somatic cell interactions in the human ovary-novel role of bone morphogenetic proteins and growth differentiation factors. Hum Reprod Update. 2016;23:1-18 pubmed
  2. Fang Y, Chang H, Cheng J, Klausen C, Leung P, Yang X. Transforming growth factor-?1 increases lysyl oxidase expression by downregulating MIR29A in human granulosa lutein cells. Reproduction. 2016;152:205-13 pubmed publisher
    ..Our findings suggest that TGFB1 and MIR29A may play essential roles in the regulation of extracellular matrix remodeling during the periovulatory phase. ..
  3. Zhang X, Chang H, Zhu H, Liu R, Leung P. BMP6 increases TGF-β1 production by up-regulating furin expression in human granulosa-lutein cells. Cell Signal. 2019;55:109-118 pubmed publisher
    ..Our findings provide insights into the molecular interactions and mechanisms of two intrafollicular growth factors in hGL cells. ..
  4. Bai L, Chang H, Zhu Y, Leung P. Bone morphogenetic protein 2 increases lysyl oxidase activity via up-regulation of snail in human granulosa-lutein cells. Cell Signal. 2019;53:201-211 pubmed publisher
    ..These findings may provide insights into the functional role of BMP2 in the regulation of ECM formation during folliculogenesis. ..
  5. Yi Y, Cheng J, Klausen C, Leung P. TGF-?1 inhibits human trophoblast cell invasion by upregulating cyclooxygenase-2. Placenta. 2018;68:44-51 pubmed publisher
    ..Clinically, targeting TGF-?1/COX-2 could be a useful therapeutic strategy for the treatment of placental disorders. ..
  6. Chang H, Cheng J, Klausen C, Leung P. BMP15 suppresses progesterone production by down-regulating StAR via ALK3 in human granulosa cells. Mol Endocrinol. 2013;27:2093-104 pubmed publisher
    ..Our findings suggest that oocyte may play a critical role in the regulation of progesterone to prevent premature luteinization during the late stage of follicle development. ..
  7. So W, Cheng J, Fan Q, Wong A, Huntsman D, Gilks C, et al. Loss of Sprouty2 in human high-grade serous ovarian carcinomas promotes EGF-induced E-cadherin down-regulation and cell invasion. FEBS Lett. 2015;589:302-9 pubmed publisher
    ..This study reveals the loss of SPRY2 in HGSC and indicates an important tumor-suppressive role for SPRY2 in mediating the stimulatory effect of EGF on human EOC progression. ..
  8. Chang H, Fang L, Cheng J, Klausen C, Sun Y, Leung P. Growth differentiation factor 8 down-regulates pentraxin 3 in human granulosa cells. Mol Cell Endocrinol. 2015;404:82-90 pubmed publisher
    ..These novel findings support a potential role for GDF8 in the regulation of follicular function, likely via autocrine effects on human granulosa cells. ..
  9. So W, Fan Q, Lau M, Qiu X, Cheng J, Leung P. Amphiregulin induces human ovarian cancer cell invasion by down-regulating E-cadherin expression. FEBS Lett. 2014;588:3998-4007 pubmed publisher
    ..This study demonstrates that AREG induces ovarian cancer cell invasion by down-regulating E-cadherin expression. ..

More Information

Publications31

  1. Fan Q, Cheng J, Qiu X, Chang H, Leung P. EpCAM is up-regulated by EGF via ERK1/2 signaling and suppresses human epithelial ovarian cancer cell migration. Biochem Biophys Res Commun. 2015;457:256-61 pubmed publisher
    ..This study demonstrates the regulation of EpCAM and its role in mediating the effects of EGF on human EOC cell migration. ..
  2. Qiu X, Cheng J, Zhao J, Chang H, Leung P. Transforming growth factor-β stimulates human ovarian cancer cell migration by up-regulating connexin43 expression via Smad2/3 signaling. Cell Signal. 2015;27:1956-62 pubmed publisher
    ..Moreover, knockdown of Cx43 attenuates TGF-β-stimulated cell migration. This study demonstrates an important role for Cx43 in mediating the effects of TGF-β on human ovarian cancer cell migration. ..
  3. Chen Y, Chang H, Cheng J, Tsai H, Wu C, Leung P. Transforming growth factor-β1 up-regulates connexin43 expression in human granulosa cells. Hum Reprod. 2015;30:2190-201 pubmed publisher
    ..This research was supported by an operating grant from the Canadian Institutes of Health Research to P.C.K.L. There are no conflicts of interest to declare. NA. ..
  4. Qiu X, Cheng J, Klausen C, Fan Q, Chang H, So W, et al. Transforming growth factor-α induces human ovarian cancer cell invasion by down-regulating E-cadherin in a Snail-independent manner. Biochem Biophys Res Commun. 2015;461:128-35 pubmed publisher
    ..This study shows that TGF-α uses common and divergent molecular mediators to regulate E-cadherin expression and cell invasion. ..
  5. Zhang H, Tian S, Klausen C, Zhu H, Liu R, Leung P. Differential activation of noncanonical SMAD2/SMAD3 signaling by bone morphogenetic proteins causes disproportionate induction of hyaluronan production in immortalized human granulosa cells. Mol Cell Endocrinol. 2016;428:17-27 pubmed publisher
    ..Our results suggest differential activation of noncanonical SMAD2/SMAD3 signaling by BMPs causes disproportionate induction of HAS2 expression and hyaluronan production in immortalized human granulosa cells. ..
  6. Cheng J, Chang H, Liu P, Leung P. Sphingosine-1-phosphate induces COX-2 expression and PGE2 production in human granulosa cells through a S1P1/3-mediated YAP signaling. Cell Signal. 2016;28:643-51 pubmed publisher
    ..These results provide evidence that S1P induces COX-2 expression and PGE2 production in human granulosa cells through a S1P1/3-mediated YAP signaling pathway. ..
  7. Chang H, Fang L, Cheng J, Taylor E, Sun Y, Leung P. Effects of growth differentiation factor 8 on steroidogenesis in human granulosa-lutein cells. Fertil Steril. 2016;105:520-8 pubmed publisher
    ..In human granulosa cells, GDF8 may play an important role in the modulation of cellular responsiveness to gonadotropins and in the regulation of ovarian steroid production, most likely as a luteinization inhibitor. ..
  8. Chang H, Pan H, Cheng J, Zhu Y, Leung P. Growth differentiation factor 8 suppresses cell proliferation by up-regulating CTGF expression in human granulosa cells. Mol Cell Endocrinol. 2016;422:9-17 pubmed publisher
    ..Our findings suggest that GDF8 and CTGF may play critical roles in the regulation of proliferative events in human granulosa cells. ..
  9. Peng B, Zhu H, Klausen C, Ma L, Wang Y, Leung P. GnRH regulates trophoblast invasion via RUNX2-mediated MMP2/9 expression. Mol Hum Reprod. 2016;22:119-29 pubmed publisher
    ..Not applicable. This research was supported by Canadian Institutes of Health Research (Grant #143317) to P.C.K.L. The authors have nothing to disclose. ..
  10. Zhao H, Klausen C, Li Y, Zhu H, Wang Y, Leung P. Bone morphogenetic protein 2 promotes human trophoblast cell invasion by upregulating N-cadherin via non-canonical SMAD2/3 signaling. Cell Death Dis. 2018;9:174 pubmed publisher
    ..Our results show that BMP2 promotes trophoblast cell invasion by upregulating N-cadherin via non-canonical ALK2/3/4-SMAD2/3-SMAD4 signaling. ..
  11. So W, Cheng J, Liu Y, Xu C, Zhao J, Chang V, et al. Sprouty4 mediates amphiregulin-induced down-regulation of E-cadherin and cell invasion in human ovarian cancer cells. Tumour Biol. 2016;37:9197-207 pubmed publisher
    ..Moreover, SPRY4 knockdown attenuated AREG-induced cell migration and invasion. Overexpression of SPRY4 enhanced AREG-induced cell invasion. This study reveals that SPRY4 is involved in EGFR-mediated human ovarian cancer progression. ..
  12. Chang H, Fang Y, Liu P, Cheng J, Yang X, Leung P. Connective tissue growth factor mediates growth differentiation factor 8-induced increase of lysyl oxidase activity in human granulosa-lutein cells. Mol Cell Endocrinol. 2016;434:186-98 pubmed publisher
    ..Our findings suggest that GDF8 and CTGF may play critical roles in the regulation of ECM formation in human granulosa cells. ..
  13. Zhao J, Klausen C, Xiong S, Cheng J, Chang H, Leung P. Growth differentiation factor 8 induces SKOV3 ovarian cancer cell migration and E-cadherin down-regulation. Cell Signal. 2016;28:1615-22 pubmed publisher
    ..Importantly, GDF8 treatment increases SKOV3 cell migration and this effect is blocked by SB431542. Our study suggests that GDF8 promotes ovarian cancer cell migration via ALK4/5-SMAD2/3-E-cadherin signaling. ..
  14. Chang H, Cheng J, Liu Y, Klausen C, Xu C, Leung P. Activin A-induced increase in LOX activity in human granulosa-lutein cells is mediated by CTGF. Reproduction. 2016;152:293-301 pubmed publisher
    ..These findings may provide insight into the mechanisms by which intrafollicular growth factors regulate the expression of LOX for ECM formation and tissue remodeling in the human ovary. ..
  15. request reprint
    Liu P, Chang H, Cheng J, Leung P. Activin A upregulates PTGS2 expression and increases PGE2 production in human granulosa-lutein cells. Reproduction. 2016;152:655-664 pubmed
    ..Our results suggest that activin A may be involved in the modulation of human corpus luteum formation via the induction of PTGS2 expression and PGE2 production. ..
  16. Xiong S, Klausen C, Cheng J, Leung P. TGF?1 induces endometrial cancer cell adhesion and migration by up-regulating integrin ?v?3 via SMAD-independent MEK-ERK1/2 signaling. Cell Signal. 2017;34:92-101 pubmed publisher
    ..Our results suggest that TGF?1-MEK-ERK1/2-integrin ?v?3 signaling could contribute to the invasive behaviour of high-risk endometrial cancer by promoting cell adhesion and migration. ..
  17. Bai L, Chang H, Cheng J, Klausen C, Chu G, Leung P, et al. SMAD1/5 mediates bone morphogenetic protein 2-induced up-regulation of BAMBI expression in human granulosa-lutein cells. Cell Signal. 2017;37:52-61 pubmed publisher
    ..Our findings indicate that BAMBI is a BMP-responsive gene and that BAMBI participates in the negative feedback regulation of TGF-? signaling in the human ovary. ..
  18. Bai L, Chang H, Cheng J, Chu G, Leung P, Yang G. Lithium chloride inhibits StAR and progesterone production through GSK-3? and ERK1/2 signaling pathways in human granulosa-lutein cells. Mol Cell Endocrinol. 2018;461:89-99 pubmed publisher
    ..Our findings deepen our understanding of the pathological effects and the underlying molecular mechanisms of how lithium might affect the female reproductive system. ..
  19. Cheng J, Yi Y, Chang H, Leung P. TGF-β1 up-regulates cadherin-11 expression through Snail: A potential mechanism for human trophoblast cell differentiation. Cell Signal. 2018;43:55-61 pubmed publisher
    ..Our results suggest that TGFβ1-SMAD2/3-Snail signaling could contribute to the human trophoblast cell differentiation by up-regulating cadherin-11 expression. ..
  20. Chang H, Cheng J, Huang H, Shi F, Leung P. Activin A, B and AB decrease progesterone production by down-regulating StAR in human granulosa cells. Mol Cell Endocrinol. 2015;412:290-301 pubmed publisher
    ..Our findings provide important insights into the molecular mechanisms underlying the regulatory effects of activins on human granulosa cell steroidogenesis. ..
  21. Fang L, Cheng J, Chang H, Sun Y, Leung P. EGF-like growth factors induce COX-2-derived PGE2 production through ERK1/2 in human granulosa cells. J Clin Endocrinol Metab. 2013;98:4932-41 pubmed publisher
    ..However, whether the same is true in humans remains largely unknown...
  22. Wu H, Wang H, Huang H, Lai C, Lee C, Soong Y, et al. Gonadotropin-releasing hormone type II (GnRH-II) agonist regulates the invasiveness of endometrial cancer cells through the GnRH-I receptor and mitogen-activated protein kinase (MAPK)-dependent activation of matrix metalloproteinase (MMP)-2. BMC Cancer. 2013;13:300 pubmed publisher
    ..In mammals, expression of GnRH-II is higher than GnRH-I in reproductive tissues. Here, we examined the effect of a GnRH-II agonist on the motility of endometrial cancer cells and its mechanism of action in endometrial cancer therapy...