W D Leslie

Summary

Affiliation: University of Manitoba
Country: Canada

Publications

  1. ncbi request reprint Biphasic fracture risk in diabetes: a population-based study
    William D Leslie
    Department of Medicine C5121, University of Manitoba, 409 Tache Avenue, Winnipeg, Manitoba, Canada R2H 2A6
    Bone 40:1595-601. 2007
  2. doi request reprint The post-fracture care gap among Canadian First Nations peoples: a retrospective cohort study
    W D Leslie
    Department of Medicine, C5121, University of Manitoba, 409 Tache Avenue, Winnipeg, Manitoba, Canada R2H 2A6
    Osteoporos Int 23:929-36. 2012
  3. ncbi request reprint Lumbar spine texture enhances 10-year fracture probability assessment
    W D Leslie
    Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Osteoporos Int 25:2271-7. 2014
  4. ncbi request reprint Choice of lumbar spine bone density reference database for fracture prediction in men and women: a population-based analysis
    William D Leslie
    Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada Electronic address
    J Clin Densitom 17:295-300. 2014
  5. doi request reprint Treatment implications for men when switching from male to female bone mineral density reference data: the Manitoba Bone Density Program
    William D Leslie
    Department of Medicine, University of Manitoba, Winnipeg, MB, Canada Electronic address
    J Clin Densitom 16:537-42. 2013
  6. doi request reprint Selection of women aged 50-64 yr for bone density measurement
    William D Leslie
    Department of Medicine, University of Manitoba, Winnipeg, MB, Canada Electronic address
    J Clin Densitom 16:570-8. 2013
  7. doi request reprint Direct comparison of eight national FRAX® tools for fracture prediction and treatment qualification in Canadian women
    W D Leslie
    Department of Medicine C5121, University of Manitoba, 409 Tache Avenue, St Boniface General Hospital, Winnipeg R2H 2A6, Canada
    Arch Osteoporos 8:145. 2013
  8. doi request reprint Clinical factors associated with trabecular bone score
    William D Leslie
    Department of Medicine, University of Manitoba, Winnipeg, MB, Canada
    J Clin Densitom 16:374-9. 2013
  9. doi request reprint Cost-effectiveness of two inexpensive postfracture osteoporosis interventions: results of a randomized trial
    Sumit R Majumdar
    Department of Medicine, University of Alberta, and the Institute of Health Economics, Edmonton, Alberta, Canada T6G 2B7
    J Clin Endocrinol Metab 98:1991-2000. 2013
  10. doi request reprint Direct healthcare costs for 5 years post-fracture in Canada: a long-term population-based assessment
    W D Leslie
    Department of Medicine C5121, University of Manitoba, 409 Tache Avenue, Winnipeg, Manitoba, Canada
    Osteoporos Int 24:1697-705. 2013

Detail Information

Publications126 found, 100 shown here

  1. ncbi request reprint Biphasic fracture risk in diabetes: a population-based study
    William D Leslie
    Department of Medicine C5121, University of Manitoba, 409 Tache Avenue, Winnipeg, Manitoba, Canada R2H 2A6
    Bone 40:1595-601. 2007
    ..It is hypothesized that the opposing effects of overweight/obesity and diabetes-related complications contribute to the observed biphasic fracture risk, though causality cannot be proven from this observational study...
  2. doi request reprint The post-fracture care gap among Canadian First Nations peoples: a retrospective cohort study
    W D Leslie
    Department of Medicine, C5121, University of Manitoba, 409 Tache Avenue, Winnipeg, Manitoba, Canada R2H 2A6
    Osteoporos Int 23:929-36. 2012
    ..First Nations peoples were eight times less likely to receive post-fracture care compared to non-First Nations peoples, representing a clinically significant ethnic difference in post-fracture care...
  3. ncbi request reprint Lumbar spine texture enhances 10-year fracture probability assessment
    W D Leslie
    Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Osteoporos Int 25:2271-7. 2014
    ..We found that lumbar spine texture analysis using trabecular bone score (TBS) is a risk factor for MOF and a risk factor for death in a retrospective cohort study from a large clinical registry for the province of Manitoba, Canada...
  4. ncbi request reprint Choice of lumbar spine bone density reference database for fracture prediction in men and women: a population-based analysis
    William D Leslie
    Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada Electronic address
    J Clin Densitom 17:295-300. 2014
    ..The least complicated model for describing fracture risk is therefore to use the same reference lumbar spine data for generating T-scores in men and women. ..
  5. doi request reprint Treatment implications for men when switching from male to female bone mineral density reference data: the Manitoba Bone Density Program
    William D Leslie
    Department of Medicine, University of Manitoba, Winnipeg, MB, Canada Electronic address
    J Clin Densitom 16:537-42. 2013
    ..We conclude that choice of male or female reference data for T-score calculation in men has little effect on overall treatment eligibility rates under NOF guidelines...
  6. doi request reprint Selection of women aged 50-64 yr for bone density measurement
    William D Leslie
    Department of Medicine, University of Manitoba, Winnipeg, MB, Canada Electronic address
    J Clin Densitom 16:570-8. 2013
    ..These data may help to inform an evidence-based approach for targeting BMD testing in postmenopausal women younger than 65yr under the NOF treatment guidelines...
  7. doi request reprint Direct comparison of eight national FRAX® tools for fracture prediction and treatment qualification in Canadian women
    W D Leslie
    Department of Medicine C5121, University of Manitoba, 409 Tache Avenue, St Boniface General Hospital, Winnipeg R2H 2A6, Canada
    Arch Osteoporos 8:145. 2013
    ..Our data underscores the importance of applying country-specific FRAX tools that are based upon high-quality national fracture epidemiology...
  8. doi request reprint Clinical factors associated with trabecular bone score
    William D Leslie
    Department of Medicine, University of Manitoba, Winnipeg, MB, Canada
    J Clin Densitom 16:374-9. 2013
    ..Further work is needed to determine whether lumbar spine TBS can replace some of the clinical risk factors currently used in fracture risk assessment...
  9. doi request reprint Cost-effectiveness of two inexpensive postfracture osteoporosis interventions: results of a randomized trial
    Sumit R Majumdar
    Department of Medicine, University of Alberta, and the Institute of Health Economics, Edmonton, Alberta, Canada T6G 2B7
    J Clin Endocrinol Metab 98:1991-2000. 2013
    ..The cost-effectiveness of these interventions is unknown...
  10. doi request reprint Direct healthcare costs for 5 years post-fracture in Canada: a long-term population-based assessment
    W D Leslie
    Department of Medicine C5121, University of Manitoba, 409 Tache Avenue, Winnipeg, Manitoba, Canada
    Osteoporos Int 24:1697-705. 2013
    ..Economic analyses that do not account for the possibility of a long-term reduction in direct healthcare costs in the post-fracture population may systematically overestimate the total economic burden of fracture...
  11. doi request reprint The contributions of First Nations ethnicity, income, and delays in surgery on mortality post-fracture: a population-based analysis
    W D Leslie
    Department of Medicine C5121, University of Manitoba, 409 Tache Avenue, Winnipeg, MB, R2H 2A6, Canada
    Osteoporos Int 24:1247-56. 2013
    ..Lower income also predicted increased mortality post-fracture...
  12. ncbi request reprint TBS (trabecular bone score) and diabetes-related fracture risk
    William D Leslie
    Department of Medicine C5121, St Boniface General Hospital, 409 Tache Avenue, Winnipeg, MB, Canada R2H 2A6
    J Clin Endocrinol Metab 98:602-9. 2013
    ..Trabecular bone score (TBS) is derived from the texture of the spine dual x-ray absorptiometry (DXA) image and is related to bone microarchitecture and fracture risk, providing information independent of BMD...
  13. doi request reprint Competing mortality and fracture risk assessment
    W D Leslie
    University of Manitoba, Winnipeg, MB, Canada
    Osteoporos Int 24:681-8. 2013
    ..A modified Kaplan-Meier method is easy to implement and provides an alternative approach to existing methods for competing mortality risk adjustment...
  14. doi request reprint Clinical review: Ethnic differences in bone mass--clinical implications
    William D Leslie
    Department of Medicine, University of Manitoba, Winnipeg, Canada R2H 2A6
    J Clin Endocrinol Metab 97:4329-40. 2012
    ..Differences in bone mineral density (BMD) as assessed with dual-energy x-ray absorptiometry are observed between geographic and ethnic groups, with important implications in clinical practice...
  15. doi request reprint Type 2 diabetes and bone
    William D Leslie
    Department of Medicine, University of Manitoba, Winnipeg, Canada
    J Bone Miner Res 27:2231-7. 2012
    ..The need for improved methods for identification of fracture in older adults with T2D is an important priority for osteoporosis research...
  16. pmc Measurement equivalence of the SF-36 in the Canadian Multicentre Osteoporosis Study
    Lisa M Lix
    School of Public Health, University of Saskatchewan, Saskatoon, Canada
    Health Qual Life Outcomes 10:29. 2012
    ..This study examined the measurement equivalence (ME) of the 36-item Medical Outcomes Study Short Form Survey (SF-36), a widely-used measure of HRQOL, by sex and race in a population-based Canadian sample...
  17. pmc Osteoporosis-related fracture case definitions for population-based administrative data
    Lisa M Lix
    School of Public Health, University of Saskatchewan, Saskatoon, Canada
    BMC Public Health 12:301. 2012
    ....
  18. pmc A pilot study of exercise in men with prostate cancer receiving androgen deprivation therapy
    C Ellen Lee
    Department of Physical Therapy, University of Manitoba, R106 771 McDermot Ave, Winnipeg MB R3E 0T6, Canada
    BMC Cancer 12:103. 2012
    ..The objectives of this study are to determine the efficacy of a home-based walking exercise program in promoting bone health, physical function and quality of life in men with prostate cancer receiving ADT...
  19. doi request reprint Does osteoporosis therapy invalidate FRAX for fracture prediction?
    William D Leslie
    Department of Medicine C5121, University of Manitoba, 409 Tache Avenue, Winnipeg, Manitoba, Canada
    J Bone Miner Res 27:1243-51. 2012
    ..Although FRAX should not be used to assess the reduction in fracture risk in individuals on treatment, it may still have value for guiding the need for continued treatment or treatment withdrawal..
  20. ncbi request reprint Rate of bone density change does not enhance fracture prediction in routine clinical practice
    William D Leslie
    University of Manitoba and Department of Medicine C5121, 409 Tache Avenue, St Boniface General Hospital, Winnipeg, Manitoba, Canada R2H 2A6
    J Clin Endocrinol Metab 97:1211-8. 2012
    ..There is contradictory information on whether the rate of bone mineral density (BMD) loss is an independent risk factor for osteoporotic fractures and whether this should be included in fracture prediction systems...
  21. doi request reprint A population-based analysis of the post-fracture care gap 1996-2008: the situation is not improving
    W D Leslie
    Department of Medicine, University of Manitoba, C5121 409 Tache Avenue, Winnipeg, MB R2H 2A6, Canada
    Osteoporos Int 23:1623-9. 2012
    ..The post-fracture care gap has not narrowed in recent years. Following an initial improvement, rates of medication initiation have actually declined...
  22. pmc Closing the gap in postfracture care at the population level: a randomized controlled trial
    William D Leslie
    University of Manitoba, Winnipeg, Man
    CMAJ 184:290-6. 2012
    ..Postfracture care is suboptimal, and strategies to address this major gap in care are necessary. We investigated whether notifications sent by mail to physicians and patients would lead to improved postfracture care...
  23. doi request reprint A comparative study of using non-hip bone density inputs with FRAX®
    W D Leslie
    University of Manitoba, Winnipeg, Canada
    Osteoporos Int 23:853-60. 2012
    ..Use of a weighted mean between the lumbar spine and femoral neck T-scores was found to provide an arithmetically equivalent result to a previously described offset adjustment...
  24. doi request reprint Fracture risk assessment without bone density measurement in routine clinical practice
    W D Leslie
    Department of Medicine C5121, University of Manitoba, 409 Tache Avenue, Winnipeg, MB, Canada R2H 2A6
    Osteoporos Int 23:75-85. 2012
    ..For individuals falling in a moderate risk range, there is incremental value in using BMD in the probability calculation as this appropriately reclassifies risk in over one third of the individuals...
  25. doi request reprint High fracture probability with FRAX usually indicates densitometric osteoporosis: implications for clinical practice
    W D Leslie
    University of Manitoba, Winnipeg, Canada
    Osteoporos Int 23:391-7. 2012
    ....
  26. ncbi request reprint Prediction of body composition from spine and hip bone densitometry
    William D Leslie
    Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    J Clin Densitom 12:428-33. 2009
    ..Further research is needed to see whether these measures can in turn predict the metabolic complications associated with overweight and obesity...
  27. ncbi request reprint Trends in hip fracture rates in Canada
    William D Leslie
    Department of Medicine, University of Manitoba, Winnipeg, Canada
    JAMA 302:883-9. 2009
    ..Hip fractures are a public health concern because they are associated with significant morbidity, excess mortality, and the majority of the costs directly attributable to osteoporosis...
  28. ncbi request reprint Factors affecting short-term bone density precision assessment and the effect on patient monitoring
    William D Leslie
    Department of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    J Bone Miner Res 23:199-204. 2008
    ....
  29. ncbi request reprint Imputation of 10-year osteoporotic fracture rates from hip fractures: a clinical validation study
    William D Leslie
    Faculty of Medicine, University of Manitoba, Winnipeg, Canada
    J Bone Miner Res 25:388-92. 2010
    ..Since collection of population-based hip fracture data is considerably easier than collection of non-hip fracture data, this study supports the current emphasis on using hip fractures as the preferred site for FRAX model calibration...
  30. ncbi request reprint Prediction of hip and other osteoporotic fractures from hip geometry in a large clinical cohort
    W D Leslie
    Department of Medicine, University of Manitoba, Winnipeg, Canada
    Osteoporos Int 20:1767-74. 2009
    ..7 years of observation. Hip axis length (HAL) and strength index (SI) made a small but statistically significant contribution to hip fracture prediction that was independent of age and hip bone density...
  31. doi request reprint Bone density and fragility fractures in patients with developmental disabilities
    W D Leslie
    Section of Nuclear Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Osteoporos Int 20:379-83. 2009
    ..We found a very high prevalence of BMD in the osteoporotic range and a significant correlation between lower BMD and prior fragility fractures...
  32. ncbi request reprint Ethnic differences in adiposity and body composition: the First Nations bone health study
    William D Leslie
    Faculty of Medicine C5121, 409 Tache Ave, University of Manitoba, Winnipeg, MB R2H 2A6, Canada
    Appl Physiol Nutr Metab 32:1065-72. 2007
    ..First Nations women had a preferential increase in trunk fat and this may contribute to high reported rates of diabetes, metabolic syndrome, and cardiovascular events...
  33. doi request reprint Body mass and composition affect bone density in recently diagnosed inflammatory bowel disease: the Manitoba IBD Cohort Study
    William D Leslie
    Department of Medicine, University of Manitoba, Winnipeg, MB, Canada
    Inflamm Bowel Dis 15:39-46. 2009
    ..This prospective study was undertaken to clarify the role of body mass and composition as a determinant of bone mineral density (BMD) in recently diagnosed inflammatory bowel disease (IBD)...
  34. doi request reprint Validation of ten-year fracture risk prediction: a clinical cohort study from the Manitoba Bone Density Program
    William D Leslie
    Department of Medicine C5121, 409 Tache Avenue, Winnipeg, Manitoba, Canada
    Bone 43:667-71. 2008
    ..Absolute 10-year fracture risk is the preferred method for fracture risk assessment. The validity of applying published fracture rates from one population to another population is uncertain...
  35. ncbi request reprint Effect of total hip bone area on osteoporosis diagnosis and fractures
    William D Leslie
    Faculty of Medicine, University of Manitoba, Winnipeg, Canada
    J Bone Miner Res 23:1468-76. 2008
    ..Incident fracture rates correlate equally well with BMD across all bone area quartiles when adjusted for age...
  36. doi request reprint Simplified system for absolute fracture risk assessment: clinical validation in Canadian women
    William D Leslie
    Department of Medicine, University of Manitoba, Winnipeg, Canada
    J Bone Miner Res 24:353-60. 2009
    ..3-16.4] per 1000 person-years) or major CS use (11.2 [95% CI, 4.1-18.2] per 1000 person-years). This simplified fracture risk assessment system provides an assessment of fracture risk that is consistent with observed fracture rates...
  37. doi request reprint Body composition and bone density in Canadian White and Aboriginal women: the First Nations Bone Health Study
    William D Leslie
    University of Manitoba, Department of Medicine, Canada
    Bone 42:990-5. 2008
    ....
  38. doi request reprint Absolute fracture risk reporting in clinical practice: a physician-centered survey
    W D Leslie
    Department of Medicine, University of Manitoba, 409 Tache Avenue, Winnipeg R2H 2A6 Manitoba, Canada
    Osteoporos Int 19:459-63. 2008
    ..Absolute fracture risk reporting was well received and was strongly preferred to traditional T-score-based reporting. Non-specialist physicians were particularly supportive of risk-based bone mineral density (BMD) reporting...
  39. doi request reprint Population-based Canadian hip fracture rates with international comparisons
    W D Leslie
    Faculty of Medicine, Department of Medicine C5121, University of Manitoba, 409 Tache Avenue, Winnipeg, Manitoba, R2H 2A6, Canada
    Osteoporos Int 21:1317-22. 2010
    ..Use of the US fracture risk assessment tool (FRAX) would be inappropriate for Canada as it would overestimate fracture risk in Canadian women and older men...
  40. doi request reprint Abdominal fat from spine dual-energy x-ray absorptiometry and risk for subsequent diabetes
    William D Leslie
    University of Manitoba, Winnipeg, Canada R2H 2A6
    J Clin Endocrinol Metab 95:3272-6. 2010
    ..Abdominal obesity is a major risk factor for diabetes. Dual-energy x-ray absorptiometry (DXA) of the lumbar spine provides an index of abdominal fat...
  41. doi request reprint Simplified 10-year absolute fracture risk assessment: a comparison of men and women
    William D Leslie
    Department of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    J Clin Densitom 13:141-6. 2010
    ..Despite evidence of greater referral bias in men resulting in a higher rate of clinical risk factors, the performance of the prediction algorithm was not affected...
  42. ncbi request reprint Bone density monitoring with the total hip site: time for a re-evaluation?
    William D Leslie
    Department of Medicine, University of Manitoba, Winnipeg, Canada
    J Clin Densitom 7:269-74. 2004
    ..In summary, we believe that the total hip site has been undervalued for monitoring purposes and might actually be the preferred site in older individuals with a high prevalence of lumbar spine artifact...
  43. doi request reprint Effects of FRAX(®) model calibration on intervention rates: a simulation study
    William D Leslie
    Department of Medicine, University of Manitoba, Winnipeg, Canada
    J Clin Densitom 14:272-8. 2011
    ..These results highlight the importance of FRAX(®) model calibration, and speak to the importance of using high-quality fracture epidemiology in constructing FRAX(®) tools...
  44. doi request reprint Spine-hip T-score difference predicts major osteoporotic fracture risk independent of FRAX(®): a population-based report from CAMOS
    William D Leslie
    Department of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    J Clin Densitom 14:286-93. 2011
    ..In summary, the T-score difference between the lumbar spine and femoral neck is an independent risk factor for major osteoporotic fractures that is independent of the FRAX probability calculated with femoral neck BMD...
  45. doi request reprint Fracture burden in relation to low bone mineral density and FRAX(®) probability
    William D Leslie
    Department of Medicine, University of Manitoba, Winnipeg, MB, Canada
    J Clin Densitom 14:279-85. 2011
    ..Strategies to enhance risk stratification in this group should be developed through international collaborations...
  46. doi request reprint Direct costs of fractures in Canada and trends 1996-2006: a population-based cost-of-illness analysis
    William D Leslie
    Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    J Bone Miner Res 26:2419-29. 2011
    ..We found that there are large incremental health care costs associated with incident fractures in Canada. Identifying COI from HCR use offers a cost baseline for measuring the effects of evidence-based guidelines implementation...
  47. doi request reprint A review of osteoporosis diagnosis and treatment options in new and recently updated guidelines on case finding around the world
    William D Leslie
    University of Manitoba, Winnipeg, MB, Canada
    Curr Osteoporos Rep 9:129-40. 2011
    ..This paper reviews recently updated CPGs from the following countries: Australia, Belgium, Canada, Germany, the United Kingdom, and the United States...
  48. doi request reprint Construction of a FRAX® model for the assessment of fracture probability in Canada and implications for treatment
    W D Leslie
    University of Manitoba, Winnipeg, Canada
    Osteoporos Int 22:817-27. 2011
    ..This FRAX tool was used to examine possible thresholds for therapeutic intervention in Canada in two large complementary cohorts of women and men...
  49. ncbi request reprint A before-and-after study of fracture risk reporting and osteoporosis treatment initiation
    William D Leslie
    University of Manitoba, Winnipeg, Canada
    Ann Intern Med 153:580-6. 2010
    ..Several national organizations recommend that fracture risk assessment and osteoporotic treatment be based on estimated absolute 10-year fracture risk rather than bone mineral density (BMD) alone...
  50. doi request reprint Construction and validation of a simplified fracture risk assessment tool for Canadian women and men: results from the CaMos and Manitoba cohorts
    W D Leslie
    Department of Medicine, University of Manitoba, Winnipeg, MB, Canada
    Osteoporos Int 22:1873-83. 2011
    ..A procedure for creating a simplified version of fracture risk assessment tool (FRAX®) is described. Calibration, fracture prediction, and concordance were compared with the full FRAX tool using two large, complementary Canadian datasets...
  51. doi request reprint Spine-hip discordance and fracture risk assessment: a physician-friendly FRAX enhancement
    W D Leslie
    Department of Medicine, University of Manitoba, Winnipeg, Canada
    Osteoporos Int 22:839-47. 2011
    ..We describe a simple procedure for using lumbar spine BMD to enhance fracture risk assessment under the FRAX system...
  52. doi request reprint Absolute fracture risk assessment using lumbar spine and femoral neck bone density measurements: derivation and validation of a hybrid system
    William D Leslie
    Department of Medicine, University of Manitoba, Winnipeg, Canada
    J Bone Miner Res 26:460-7. 2011
    ..The improvement in fracture risk prediction is small but supports clinical interest in a system that integrates LS in fracture risk assessment...
  53. doi request reprint Independent clinical validation of a Canadian FRAX tool: fracture prediction and model calibration
    William D Leslie
    Department of Medicine, University of Manitoba, Winnipeg, Canada
    J Bone Miner Res 25:2350-8. 2010
    ..In conclusion, a Canadian FRAX tool calibrated on national hip fracture data generates fracture risk predictions that generally are consistent with observed fracture rates across a wide range of risk categories...
  54. doi request reprint Validation of a case definition for osteoporosis disease surveillance
    W D Leslie
    Department of Medicine C5121, University of Manitoba, 409 Tache Avenue, Winnipeg, Manitoba, R2H 2A6, Canada
    Osteoporos Int 22:37-46. 2011
    ..This may facilitate implementation of a population-based osteoporosis surveillance program, providing information that could help to inform and guide screening, prevention, and treatment resources...
  55. doi request reprint Secular decreases in fracture rates 1986-2006 for Manitoba, Canada: a population-based analysis
    W D Leslie
    University of Manitoba, Winnipeg, Canada
    Osteoporos Int 22:2137-43. 2011
    ..We examined trends in fracture rates over 20 years in the Province of Manitoba, Canada. Hip fractures, major low-trauma fractures, and high-trauma fractures declined significantly from 1986 to 2006...
  56. ncbi request reprint A new approach for quantifying change and test precision in bone densitometry
    William D Leslie
    University of Manitoba, Winnipeg, Manitoba, Canada
    J Clin Densitom 10:365-9. 2007
    ..Approaches that consider the error in the LSC estimate may provide more robust determinations of BMD change even when the precision study sample size is limited...
  57. ncbi request reprint Large-body radiation doses following radioiodine therapy
    W D Leslie
    Department of Nuclear Medicine, University of Manitoba, Winnipeg, Canada
    Nucl Med Commun 23:1091-7. 2002
    ..The doses measured were significantly lower than previously predicted for the adult and infant phantom. Our measurements suggest that patient contact restrictions could be made less stringent than those currently in widespread use...
  58. ncbi request reprint Reproducibility of volume-adjusted bone mineral density of spine and hip from dual X-ray absorptiometry
    W D Leslie
    Section of Nuclear Medicine, Department of Diagnostic Imaging, University of Manitoba and St Boniface Hospital, Winnipeg, Manitoba, Canada
    J Clin Densitom 4:307-12. 2001
    ..Volumetric measures of lumbar spine density can be obtained with high precision. Because of poor reproducibility in the femoral neck, the total hip region may be preferable for measuring volumetric bone density in the proximal femur...
  59. ncbi request reprint The interaction of ethnicity and chronic disease as risk factors for osteoporotic fractures: a comparison in Canadian Aboriginals and non-Aboriginals
    W D Leslie
    Department of Medicine, University of Manitoba, Winnipeg, Canada
    Osteoporos Int 17:1358-68. 2006
    ..Aboriginal Canadians have higher fractures rates than non-Aboriginals. This analysis examined the interaction of ethnicity with diabetes mellitus, disease comorbidity and substance abuse as possible explanatory variables...
  60. ncbi request reprint The impact of bone area on short-term bone density precision
    William D Leslie
    Department of Medicine, University of Manitoba, Winnipeg, Canada
    J Clin Densitom 9:150-3. 2006
    ..001), but not the total hip. A simpler "1-cm(2) rule" for the lumbar spine also predicted significantly worse spine precision (p<0.005). In conclusion, differences in bone area are sources of short-term bone density measurement error...
  61. ncbi request reprint Minimum sample size requirements for bone density precision assessment produce inconsistency in clinical monitoring
    W D Leslie
    Department of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Osteoporos Int 17:1673-80. 2006
    ..The International Society of Clinical Densitometry (ISCD) recommends that each center determine precision error using repeat measurements in 30 subjects (or an equivalent method providing 30 degrees of freedom)...
  62. ncbi request reprint Bone density and bone area in Canadian Aboriginal women: the First Nations Bone Health Study
    W D Leslie
    Department of Medicine C5121, University of Manitoba, Winnipeg, Manitoba, Canada
    Osteoporos Int 17:1755-62. 2006
    ..Canadian Aboriginal women are at increased risk of fracture compared with the general population...
  63. ncbi request reprint The scintigraphic appearance of de Quervain tenosynovitis
    William D Leslie
    Department of Nuclear Medicine, St Boniface Hospital, Winnipeg, Manitoba, Canada
    Clin Nucl Med 31:602-4. 2006
    ..The purpose of this study is to describe the scintigraphic pattern of de Quervain tenosynovitis, a common inflammatory condition of the thumb tendon sheaths related to repetitive use...
  64. ncbi request reprint Effectiveness of bone density measurement for predicting osteoporotic fractures in clinical practice
    William D Leslie
    Department of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada R2H 2A6
    J Clin Endocrinol Metab 92:77-81. 2007
    ..It has not been established that published gradients of fracture risk from study populations can be directly applied to clinical populations...
  65. ncbi request reprint Race/ethnicity and fracture risk assessment: an issue that is more than skin deep
    William D Leslie
    Department of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    J Clin Densitom 9:406-12. 2006
    ..Race/ethnicity is often a proxy for other disease-related risk factors. Understanding fundamental risk factors goes beyond the language of race/ethnicity...
  66. ncbi request reprint Number of osteoporotic sites and fracture risk assessment: a cohort study from the Manitoba Bone Density Program
    William D Leslie
    Faculty of Medicine, and Manitoba Centre for Health Policy, Department of Community Health Sciences, University of Manitoba, Winnipeg, Canada
    J Bone Miner Res 22:476-83. 2007
    ..Greater number of osteoporotic sites correlates with lower T scores at each index site. This largely explains the positive association between number of osteoporotic sites and fracture risk...
  67. ncbi request reprint A patient with autoimmune liver disease on steroids: screening and treatment of bone disease
    William D Leslie
    Department of Medicine, St Boniface General Hospital, Winnipeg, Manitoba, Canada
    Clin Gastroenterol Hepatol 4:1440-4. 2006
  68. ncbi request reprint The importance of spectrum bias on bone density monitoring in clinical practice
    William D Leslie
    Department of Medicine, C5121, University of Manitoba, 409 Tache Avenue, Winnipeg, Manitoba, Canada, R2H 2A6
    Bone 39:361-8. 2006
    ..Categorization of change based upon absolute change in BMD is strongly preferred in the routine clinical setting...
  69. ncbi request reprint The impact of hip subregion reference data on osteoporosis diagnosis
    William D Leslie
    Faculty of Medicine, University of Manitoba, 409 Tache Avenue, Winnipeg, R2H 2A6, Canada
    Osteoporos Int 16:1669-74. 2005
    ..The impact of changes in reference data need to be carefully evaluated by users and manufacturers before widespread clinical dissemination...
  70. ncbi request reprint Parathyroid 99mTc-sestamibi scintigraphy: dual-tracer subtraction is superior to double-phase washout
    William D Leslie
    Section of Nuclear Medicine, University of Manitoba and St Boniface General Hospital, Winnipeg, Canada
    Eur J Nucl Med Mol Imaging 29:1566-70. 2002
    ..Dual-tracer subtraction parathyroid imaging is superior to double-phase sestamibi-only imaging. The washout data may provide additional information in some cases, however, and an approach that combines both techniques may be optimal...
  71. ncbi request reprint Contribution of clinical risk factors to bone density-based absolute fracture risk assessment in postmenopausal women
    W D Leslie
    Department of Medicine and Radiology C5121, University of Manitoba, 409 Tache Avenue, R2H 2A6, Winnipeg, Canada
    Osteoporos Int 14:334-8. 2003
    ..In conclusion, we have shown that a multidimensional approach to hip fracture risk stratification is feasible, and greatly modifies risk stratification based on BMD alone...
  72. ncbi request reprint Establishing a regional bone density program: lessons from the Manitoba experience
    William D Leslie
    Department of Medicine, University of Manitoba, Winnipeg, Canada
    J Clin Densitom 6:275-82. 2003
    ..We report our experience with this model of bone density service delivery, which is unique in North America, and confront the challenge of balancing accessibility, clear guidelines, and fiscal responsibility...
  73. ncbi request reprint Automated quantification of 99mTc sestamibi myocardial perfusion compared with visual analysis
    William D Leslie
    Section of Nuclear Medicine, University of Manitoba, Winnipeg, Canada
    Nucl Med Commun 25:833-8. 2004
    ..Our objective was to assess the degree of concordance between the visual and automated diagnostic assessments of 99mTc sestamibi SPECT...
  74. pmc Fracture risk among First Nations people: a retrospective matched cohort study
    William D Leslie
    Department of Medicine, University of Manitoba, Winnipeg, Man
    CMAJ 171:869-73. 2004
    ..We sought to determine the overall and site-specific fracture rates of First Nations people compared with non-First Nations people...
  75. ncbi request reprint A population-based study of osteoporosis testing and treatment following introduction of a new bone densitometry service
    William D Leslie
    Department of Medicine C5121, St Boniface General Hospital, 409 Tache Avenue, Winnipeg, R2H 2A6, Canada
    Osteoporos Int 16:773-82. 2005
    ....
  76. ncbi request reprint Demographic risk factors for fracture in First Nations people
    William D Leslie
    Department of Medicine, University of Manitoba, 409 Tache Avenue, Winnipeg, MB R2H 2A6
    Can J Public Health 96:S45-50. 2005
    ..This analysis focusses on geographic area of residence, income level, and diabetes mellitus as possible explanatory variables since they have been implicated in the fracture rates observed in other populations...
  77. ncbi request reprint Prognostic value of automated quantification of 99mTc-sestamibi myocardial perfusion imaging
    William D Leslie
    Section of Nuclear Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    J Nucl Med 46:204-11. 2005
    ....
  78. ncbi request reprint Construction and validation of a population-based bone densitometry database
    William D Leslie
    Department of Medicine C5121, St Boniface General Hospital, 409 Tache Avenue, Winnipeg, Canada R2H 2A6
    J Clin Densitom 8:25-30. 2005
    ..In conclusion, the Manitoba bone density database has great potential as a resource for clinical and health policy research because it is population based with a high level of completeness and accuracy...
  79. ncbi request reprint Prognostic value of lung sestamibi uptake in myocardial perfusion imaging of patients with known or suspected coronary artery disease
    William D Leslie
    Department of Nuclear Medicine, St Boniface General Hospital, Winnipeg, Canada
    J Am Coll Cardiol 45:1676-82. 2005
    ..We sought to determine whether lung uptake of technetium-99m (99mTc)-based myocardial perfusion tracers predicts cardiac events...
  80. ncbi request reprint Clinical risk factors for fracture in postmenopausal Canadian women: a population-based prevalence study
    William D Leslie
    University of Manitoba, Winnipeg, Canada
    Bone 40:991-6. 2007
    ..The availability of age-specific risk factor prevalence rates in this population may allow for more accurate fracture risk modeling...
  81. ncbi request reprint Bone mineral density testing in healthy postmenopausal women. The role of clinical risk factor assessment in determining fracture risk
    William D Leslie
    Department of Medicine, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
    J Clin Densitom 5:117-30. 2002
    ....
  82. ncbi request reprint Comparative effects of densitometric and absolute fracture risk classification systems on projected intervention rates in postmenopausal women
    William D Leslie
    Department of Medicine, University of Manitoba, Winnipeg, Canada
    J Clin Densitom 10:124-31. 2007
    ..The profile reversed after age 65 yr, with a greater proportion considered high risk in the 10-yr fracture risk system compared to the densitometric system...
  83. ncbi request reprint Single-site vs multisite bone density measurement for fracture prediction
    William D Leslie
    Faculty of Medicine, University of Manitoba, Winnipeg, MB R2H 2A6, Canada
    Arch Intern Med 167:1641-7. 2007
    ..Bone density measurement with dual-energy x-ray absorptiometry is widely used for fracture risk assessment. Discordance between measurement sites is common, but it is unclear how this affects fracture prediction...
  84. ncbi request reprint Exclusion of focal vertebral artifacts from spine bone densitometry and fracture prediction: a comparison of expert physicians, three computer algorithms, and the minimum vertebra
    James F Tsang
    Manitoba Bone Density Program, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
    J Bone Miner Res 22:789-98. 2007
    ..All methods of vertebral exclusion led to a small improvement in fracture prediction. Computer algorithms performed at least as well as physicians...
  85. doi request reprint Weight and body mass index predict bone mineral density and fractures in women aged 40 to 59 years
    S Morin
    Department of Medicine, McGill University, Montreal, Canada
    Osteoporos Int 20:363-70. 2009
    ..Weight and body mass index are associated with low bone mineral density and fractures in older women. This retrospective cohort study confirms a similar relationship in women aged 40 to 59 years...
  86. doi request reprint High bone mineral density is associated with high body mass index
    S Morin
    Department of Medicine, McGill University, Montreal, Canada
    Osteoporos Int 20:1267-71. 2009
    ..High BMD is an infrequent finding. In this retrospective cohort study of women 50 years and older, we documented a strong association between high BMD and high BMI...
  87. ncbi request reprint Bone density in a population-based cohort of premenopausal adult women with early onset inflammatory bowel disease
    Charles N Bernstein
    Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Am J Gastroenterol 98:1094-100. 2003
    ....
  88. doi request reprint Parathyroid hormone is predictive of low bone mass in Canadian aboriginal and white women
    Hope A Weiler
    Human Nutritional Sciences, University of Manitoba, Winnipeg, MB, Canada
    Bone 42:498-504. 2008
    ..In conclusion, PTH is a better predictor of BMD than 25(OH)D in this population of Aboriginal and White women...
  89. ncbi request reprint Vitamin D status and bone density in recently diagnosed inflammatory bowel disease: the Manitoba IBD Cohort Study
    William D Leslie
    Department of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Am J Gastroenterol 103:1451-9. 2008
    ..Bone mineral density (BMD) is usually normal at the time of inflammatory bowel disease (IBD) diagnosis. The purpose of this study was to evaluate the role of vitamin D metabolism in recently diagnosed IBD...
  90. ncbi request reprint The effect of socioeconomic status on bone density testing in a public health-care system
    S Demeter
    Radiology, University of Manitoba, Winnipeg, MB, Canada
    Osteoporos Int 18:153-8. 2007
    ..Our hypothesis was that there would be a positive association between SES and BMD utilization (i.e. higher utilization rates in higher income women), resulting in disparities that disadvantage lower SES or lower income women...
  91. doi request reprint Proton-pump inhibitor use is not associated with osteoporosis or accelerated bone mineral density loss
    Laura E Targownik
    Section of Gastroenterology, Division of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Gastroenterology 138:896-904. 2010
    ..The mechanism by which PPI use promotes the development of hip fracture is uncharacterized. Therefore, we sought to determine whether PPI use is associated with osteoporosis or accelerated bone mineral density (BMD) loss...
  92. doi request reprint Using multiple data features improved the validity of osteoporosis case ascertainment from administrative databases
    Lisa M Lix
    Manitoba Centre for Health Policy, University of Manitoba, Canada
    J Clin Epidemiol 61:1250-60. 2008
    ..The aim was to construct and validate algorithms for osteoporosis case ascertainment from administrative databases and to estimate the population prevalence of osteoporosis for these algorithms...
  93. ncbi request reprint Changes to osteoporosis prevalence according to method of risk assessment
    J Brent Richards
    Department of Medicine, McGill University, Montreal, Quebec, Canada
    J Bone Miner Res 22:228-34. 2007
    ....
  94. ncbi request reprint Application of the 1994 WHO classification to populations other than postmenopausal Caucasian women: the 2005 ISCD Official Positions
    William D Leslie
    University of Manitoba, Winnipeg, Manitoba, Canada, and McGuire Veterans Affairs Medical Center, Richmond, VA, USA
    J Clin Densitom 9:22-30. 2006
    ..quot; T-scores are preferred and the WHO classification is applicable for postmenopausal women and men age 50 and older. These Official Positions, rationale and evidence are discussed in the following report...
  95. ncbi request reprint Ethnicity, insulin resistance, and inflammatory adipokines in women at high and low risk for vascular disease
    Josef V Silha
    Department of Internal Medicine, University of Manitoba, 715 McDermot Avenue, Winnipeg, R3E 3P4 Canada
    Diabetes Care 30:286-91. 2007
    ..We sought to compare the relationship between body composition, insulin resistance, and inflammatory adipokines in Aboriginal Canadian women, who are at high risk of vascular disease, with white women...
  96. ncbi request reprint Lack of relationship of calcium and vitamin D intake to bone mineral density in premenopausal women with inflammatory bowel disease
    Charles N Bernstein
    University of Manitoba Inflammatory Bowel Disease Clinical and Research Centre, Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Am J Gastroenterol 98:2468-73. 2003
    ..The objective of this study was to assess calcium and vitamin D intake and its relationship to bone mineral density (BMD) in premenopausal women with IBD...
  97. pmc Use of proton pump inhibitors and risk of osteoporosis-related fractures
    Laura E Targownik
    Department of Gastroenterology, Division of Internal Medicine, University of Manitoba, Winnipeg, Man
    CMAJ 179:319-26. 2008
    ..The use of proton pump inhibitors has been associated with an increased risk of hip fracture. We sought to further explore the relation between duration of exposure to proton pump inhibitors and osteoporosis-related fractures...
  98. ncbi request reprint Pediatric appendicitis rupture rate: disparities despite universal health care
    Ioana Bratu
    Department of Pediatric General Surgery, Faculty of Medicine, University of Alberta, Stollery Children s Hospital, Edmonton, Alberta, Canada
    J Pediatr Surg 43:1964-9. 2008
    ..We seek to explore if, in the Canadian system of public, universal health care access, pediatric appendicitis rupture rates are an indicator of health disparities...
  99. doi request reprint Tamoxifen use and osteoporotic fracture risk: a population-based analysis
    Andrew L Cooke
    CancerCare Manitoba, Winnipeg, MB, Canada
    J Clin Oncol 26:5227-32. 2008
    ..A population-based case-control study was undertaken to determine whether tamoxifen use is associated with osteoporotic fractures in routine clinical practice...