Research Topics
| Francesco LeriSummaryAffiliation: University of Guelph Country: Canada Publications
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Detail Information
Publications
High-dose methadone maintenance in rats: effects on cocaine self-administration and behavioral side effectsFrancesco Leri
Department of Psychology, University of Guelph, Guelph, ON, Canada NIG 2WI
Neuropsychopharmacology 32:2290-300. 2007..Taken together, these results from studies in rats support the usefulness of larger doses of methadone to reduce severe cocaine abuse in opioid-dependent individuals and possibly in the management of pure-cocaine addiction...
Reacquisition of heroin and cocaine place preference involves a memory consolidation process sensitive to systemic and intra-ventral tegmental area naloxoneMartin Sticht
Department of Psychology, University of Guelph, Guelph, Canada N1G 2W1
Neurobiol Learn Mem 93:248-60. 2010....- Effects of post-training heroin and d-amphetamine on consolidation of win-stay learning and fear conditioningFrancesco Leri
Psychology, University of Guelph, Guelph, Canada
J Psychopharmacol 27:292-301. 2013..These results support the hypothesis that one of the ways in which drugs of abuse such as opiates and psychomotor stimulants reinforce behavior is by enhancing memory consolidation processes... - Treatment-like steady-state methadone in rats interferes with incubation of cocaine sensitization and associated alterations in gene expressionFrancesco Leri
Department of Psychology, University of Guelph, Canada
Eur Neuropsychopharmacol 22:143-52. 2012.... - Co-administration of opioid agonists and antagonists in addiction and pain medicineFrancesco Leri
University of Guelph, Department of Psychology, 50 Stone Road East, Guelph, Ontario, N1G 2W1, Canada
Expert Opin Pharmacother 9:1387-96. 2008..However, repeated exposure to these drugs can lead to the development of physiologic dependence and, in some individuals, to opioid addiction... 
Steady-state methadone blocks cocaine seeking and cocaine-induced gene expression alterations in the rat brainFrancesco Leri
Department of Psychology, University of Guelph, Guelph, Canada
Eur Neuropsychopharmacol 19:238-49. 2009..This is the first demonstration that steady-state methadone administered after cocaine exposure blocks cocaine-induced behavioral and neural adaptations...- Patterns of opioid and cocaine co-use: a descriptive study in a Canadian sample of untreated opioid-dependent individualsFrancesco Leri
Department of Psychology, College of Social and Applied Human Sciences, University of Guelph, ON, Canada
Exp Clin Psychopharmacol 13:303-10. 2005..These findings indicate that different individuals display different patterns of opioids and cocaine co-use... - Effects of high-dose methadone maintenance on cocaine place conditioning, cocaine self-administration, and mu-opioid receptor mRNA expression in the rat brainFrancesco Leri
Department of Psychology, University of Guelph, Guelph, ON, Canada
Neuropsychopharmacology 31:1462-74. 2006.... - Ultra-low-dose naltrexone reduces the rewarding potency of oxycodone and relapse vulnerability in ratsFrancesco Leri
Department of Psychology, University of Guelph Guelph, ON, Canada N1G 2W1
Pharmacol Biochem Behav 82:252-62. 2005..c.). In summary, this work shows that ultra-low-dose NTX co-treatment augments the locomotor effects of oxycodone as it enhances opioid analgesia, but reduces oxycodone's rewarding potency and subsequent vulnerability to relapse... - Reconditioning of drug-related cues: a potential contributor to relapse after drug reexposureFrancesco Leri
Department of Psychology, University of Guelph, Guelph Ontario, N1G 2W1, Canada
Pharmacol Biochem Behav 80:621-30. 2005.... - Methadone maintenance reduces heroin- and cocaine-induced relapse without affecting stress-induced relapse in a rodent model of poly-drug useFrancesco Leri
Department of Psychology, University of Guelph, Guelph, Ontario, Canada
Neuropsychopharmacology 29:1312-20. 2004..These results suggest that although methadone maintenance may not reduce the direct stimulatory effects of cocaine, it has the potential to reduce both spontaneous and cocaine-primed cocaine-seeking behavior... - Heroin and cocaine co-use in a group of injection drug users in MontréalFrancesco Leri
Department of Psychology, University of Guelph, Guelph, Ont
J Psychiatry Neurosci 29:40-7. 2004..To describe the pattern of co-use of heroin and cocaine in individuals who were not receiving methadone maintenance treatment... - Effects of cocaine in rats exposed to heroinFrancesco Leri
Department of Psychology, University of Guelph, Canada
Neuropsychopharmacology 28:2102-16. 2003..In response to cocaine, however, DA activity in the Acb was significantly lower in rats withdrawn from the highest dose of heroin... - The consequences of different "lapses" on relapse to heroin seeking in ratsFrancesco Leri
Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, Canada
Exp Clin Psychopharmacol 10:339-49. 2002..Simple exposure to heroin, or to heroin-related stimuli, during the lapse had little effect on responding in the test for relapse... - Understanding polydrug use: review of heroin and cocaine co-useFrancesco Leri
Center for Studies in Behavioural Neurobiology, Concordia University, Montreal, Montreal, Canada
Addiction 98:7-22. 2003..Once clearly identified, pharmacological and neuroanatomical methods can be employed in self-administering laboratory animals to uncover the neurobiological correlates of specific patterns of co-use... - The effects of acute and chronic steady state methadone on memory retrieval in ratsErin Cummins
Department of Psychology, University of Guelph, Guelph, N1G 2W1, Ontario, Canada
Psychopharmacology (Berl) 222:225-35. 2012..Although widely prescribed to treat opioid addiction, little is known about the possible side effects of methadone on memory functions... - Unreinforced responding during limited access to heroin self-administrationErin Cummins
Department of Psychology, University of Guelph, Guelph ON, Canada N1G 2W1
Pharmacol Biochem Behav 90:420-7. 2008..This suggests that acquisition of heroin self-administration is regulated by a balance between drug effects that promote and limit heroin intake... - Inactivation of the ventromedial prefrontal cortex mimics re-emergence of heroin seeking caused by heroin reconditioningJelena Ovari
Department of Psychology, University of Guelph, 50 Stone Road East, Ontario, Canada
Neurosci Lett 444:52-5. 2008..These results indicate that the vmPFC modulates expression of extinguished heroin seeking and suggest that prefrontal inhibitory mechanisms are involved in relapse to drug seeking... - Enhancing effect of heroin on social recognition learning in male Sprague-Dawley rats: modulation by heroin pre-exposureAnnemarie Levy
Department of Psychology, University of Guelph, Guelph, Ontario, Canada
Psychopharmacology (Berl) 204:413-21. 2009..There is evidence that pre-exposure to drugs of abuse can induce sensitization to several of their effects... - Effect of acute and repeated cocaine exposure on response matching capabilities of Sprague-Dawley rats responding for sucrose on concurrent schedules of reinforcementCraig P Allen
Department of Psychology, University of Guelph, Guelph ON, Canada
Pharmacol Biochem Behav 96:96-103. 2010..These results suggest that prior exposure to cocaine can produce perseverative behavior even when animals are required to match two well-learned and rewarded response options. The implications for addictive behaviors are discussed... - Oxycodone dose-dependently imparts conditioned reinforcing properties to discrete sensory stimuli in ratsStephanie L Grella
Department of Psychology, University of Guelph, 50 Stone Rd E, Guelph, ON, N1W 2G1, Canada
Pharmacol Res 64:364-70. 2011..Therefore, the intravenous conditioned reinforcement procedure appears a useful method to study how opioid drugs impart reinforcing value to discrete environmental stimuli... - FAAH inhibitor, URB-597, promotes extinction and CB(1) antagonist, SR141716, inhibits extinction of conditioned aversion produced by naloxone-precipitated morphine withdrawal, but not extinction of conditioned preference produced by morphine in ratsLaurie A Manwell
Department of Psychology, University of Guelph, Guelph, ON N1G2W1, Canada
Pharmacol Biochem Behav 94:154-62. 2009..3). These data support previous reports that the eCB system selectively facilitates extinction of aversive memories. URB-597 may prove useful in targeting extinction of aversively motivated behaviours... - Blockade of stress-induced but not cocaine-induced reinstatement by infusion of noradrenergic antagonists into the bed nucleus of the stria terminalis or the central nucleus of the amygdalaFrancesco Leri
Center for Studies in Behavioral Neurobiology, Concordia University, H3G-1M8, Montreal, Quebec, Canada
J Neurosci 22:5713-8. 2002.... - Antidepressant-like effects of paroxetine are produced by lower doses than those which produce nauseaKatharine J Tuerke
University of Guelph, Ontario, Canada
Pharmacol Biochem Behav 93:190-5. 2009..The TR test may be beneficial for assessing the side effect of nausea in preclinical tests of new compounds... - Fos expression in mesocorticolimbic areas during heroin place conditioningMichael J M Honsberger
Department of Psychology, University of Guelph, Guelph, Ontario, Canada
Neuroreport 19:63-7. 2008..It is concluded that the medial prefrontal cortex may be the neural site whereby neural representations of novel stimuli with motivational value are associated during associative learning... - Reconditioning of heroin place preference requires the basolateral amygdalaZoe Rizos
Department of Psychology, University of Guelph, Guelph (Ontario, Canada, N1G 2W1
Pharmacol Biochem Behav 82:300-5. 2005..These results suggest that the BLA plays an important role in a putative learning process initiated by drug re-exposure which may underlie the process of relapse... - Oral gavage in rats: animal welfare evaluationPatricia V Turner
Department of Pathobiology, University of Guelph, Guelph, Canada
J Am Assoc Lab Anim Sci 51:25-30. 2012..We conclude that orogastric gavage of aqueous solutions at 5 mL/kg does not negatively affect the welfare of laboratory rats acclimated to handling... - Effect of yohimbine stress on reacquisition of oxycodone seeking in ratsAmanda T Campbell
Department of Psychology, University of Guelph, 50 Stone Rd E, Guelph, ON, N1W 2G1, Canada
Psychopharmacology (Berl) 222:247-55. 2012..Stress, a powerful precipitant of drug seeking during abstinence, may also accelerate the return to pathological patterns of intake after initial instances of drug reuse... - Reinstatement of conditioned reinforcing properties of cocaine-conditioned stimuliBenjamin Goddard
Department of Psychology, University of Guelph, Guelph, Ontario, Canada N1G 2W1
Pharmacol Biochem Behav 83:540-6. 2006..These findings suggest that cocaine primes and stress can induce reinstatement by reactivating the motivational value of cocaine-conditioned cues... - Excitotoxic lesions to the prefrontal cortex of Sprague-Dawley rats do not impair response matchingCraig P Allen
Department of Psychology, University of Guelph, Guelph, ON, Canada
Neurosci Lett 495:30-4. 2011..When animals were re-tested post-surgery, no significant impairments were found. These results indicate that, in trained rats, the PFC is not necessary for selecting responses on the basis of favorable effort-to-reward contingencies... - Nitric oxide and histone deacetylases modulate cocaine-induced mu-opioid receptor levels in PC12 cellsWarren Winick-Ng
Department of Biomedical Sciences, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
BMC Pharmacol Toxicol 13:11. 2012..Cocaine exposure has been reported to alter central μ-opioid receptor (MOR) expression in vivo. The present study employed an in vitro cellular model to explore possible mechanisms that may be involved in this action of cocaine... - Effect of food restriction on cocaine locomotor sensitization in Sprague-Dawley rats: role of kappa opioid receptorsCraig P Allen
Department of Psychology, University of Guelph, 50 Stone Road East, Guelph, ON, Canada
Psychopharmacology (Berl) 226:571-8. 2013..The interaction between repeated cocaine exposure and food restriction on sensitization to the stimulatory effects of cocaine has not been characterized... - Animal studies trigger new insights on the use of methadone maintenanceErin Cummins
PhD Student University of Guelph, Department of Psychology, Guelph ON, N1G 2W1, Canada
Expert Opin Drug Discov 4:577-86. 2009..These findings suggest that SSM could be an effective pharmacological agent to assist cocaine detoxification and prevention of relapse to cocaine abuse in individuals not co-dependent on opioid... - Using latent class analysis (LCA) to analyze patterns of drug use in a population of illegal opioid usersNeerav Monga
Centre for Addiction and Mental Health, Toronto, Ontario M5S 2S1, Canada
Drug Alcohol Depend 88:1-8. 2007..The objective of this paper is to empirically determine a categorization of illegal opioid users in Canada in order to describe and analyze drug use patterns within this population... - Involvement of arginine vasopressin and V1b receptor in heroin withdrawal and heroin seeking precipitated by stress and by heroinYan Zhou
Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10021, USA
Neuropsychopharmacology 33:226-36. 2008....