Francesco Leri

Summary

Affiliation: University of Guelph
Country: Canada

Publications

  1. ncbi request reprint High-dose methadone maintenance in rats: effects on cocaine self-administration and behavioral side effects
    Francesco Leri
    Department of Psychology, University of Guelph, Guelph, ON, Canada NIG 2WI
    Neuropsychopharmacology 32:2290-300. 2007
  2. doi request reprint Reacquisition of heroin and cocaine place preference involves a memory consolidation process sensitive to systemic and intra-ventral tegmental area naloxone
    Martin Sticht
    Department of Psychology, University of Guelph, Guelph, Canada N1G 2W1
    Neurobiol Learn Mem 93:248-60. 2010
  3. doi request reprint Effects of post-training heroin and d-amphetamine on consolidation of win-stay learning and fear conditioning
    Francesco Leri
    Psychology, University of Guelph, Guelph, Canada
    J Psychopharmacol 27:292-301. 2013
  4. pmc Treatment-like steady-state methadone in rats interferes with incubation of cocaine sensitization and associated alterations in gene expression
    Francesco Leri
    Department of Psychology, University of Guelph, Canada
    Eur Neuropsychopharmacol 22:143-52. 2012
  5. pmc Steady-state methadone blocks cocaine seeking and cocaine-induced gene expression alterations in the rat brain
    Francesco Leri
    Department of Psychology, University of Guelph, Guelph, Canada
    Eur Neuropsychopharmacol 19:238-49. 2009
  6. ncbi request reprint Co-administration of opioid agonists and antagonists in addiction and pain medicine
    Francesco Leri
    University of Guelph, Department of Psychology, 50 Stone Road East, Guelph, Ontario, N1G 2W1, Canada
    Expert Opin Pharmacother 9:1387-96. 2008
  7. ncbi request reprint Patterns of opioid and cocaine co-use: a descriptive study in a Canadian sample of untreated opioid-dependent individuals
    Francesco Leri
    Department of Psychology, College of Social and Applied Human Sciences, University of Guelph, ON, Canada
    Exp Clin Psychopharmacol 13:303-10. 2005
  8. ncbi request reprint Effects of high-dose methadone maintenance on cocaine place conditioning, cocaine self-administration, and mu-opioid receptor mRNA expression in the rat brain
    Francesco Leri
    Department of Psychology, University of Guelph, Guelph, ON, Canada
    Neuropsychopharmacology 31:1462-74. 2006
  9. ncbi request reprint Ultra-low-dose naltrexone reduces the rewarding potency of oxycodone and relapse vulnerability in rats
    Francesco Leri
    Department of Psychology, University of Guelph Guelph, ON, Canada N1G 2W1
    Pharmacol Biochem Behav 82:252-62. 2005
  10. ncbi request reprint Reconditioning of drug-related cues: a potential contributor to relapse after drug reexposure
    Francesco Leri
    Department of Psychology, University of Guelph, Guelph Ontario, N1G 2W1, Canada
    Pharmacol Biochem Behav 80:621-30. 2005

Collaborators

Detail Information

Publications39

  1. ncbi request reprint High-dose methadone maintenance in rats: effects on cocaine self-administration and behavioral side effects
    Francesco Leri
    Department of Psychology, University of Guelph, Guelph, ON, Canada NIG 2WI
    Neuropsychopharmacology 32:2290-300. 2007
    ..Taken together, these results from studies in rats support the usefulness of larger doses of methadone to reduce severe cocaine abuse in opioid-dependent individuals and possibly in the management of pure-cocaine addiction...
  2. doi request reprint Reacquisition of heroin and cocaine place preference involves a memory consolidation process sensitive to systemic and intra-ventral tegmental area naloxone
    Martin Sticht
    Department of Psychology, University of Guelph, Guelph, Canada N1G 2W1
    Neurobiol Learn Mem 93:248-60. 2010
    ....
  3. doi request reprint Effects of post-training heroin and d-amphetamine on consolidation of win-stay learning and fear conditioning
    Francesco Leri
    Psychology, University of Guelph, Guelph, Canada
    J Psychopharmacol 27:292-301. 2013
    ..These results support the hypothesis that one of the ways in which drugs of abuse such as opiates and psychomotor stimulants reinforce behavior is by enhancing memory consolidation processes...
  4. pmc Treatment-like steady-state methadone in rats interferes with incubation of cocaine sensitization and associated alterations in gene expression
    Francesco Leri
    Department of Psychology, University of Guelph, Canada
    Eur Neuropsychopharmacol 22:143-52. 2012
    ....
  5. pmc Steady-state methadone blocks cocaine seeking and cocaine-induced gene expression alterations in the rat brain
    Francesco Leri
    Department of Psychology, University of Guelph, Guelph, Canada
    Eur Neuropsychopharmacol 19:238-49. 2009
    ..This is the first demonstration that steady-state methadone administered after cocaine exposure blocks cocaine-induced behavioral and neural adaptations...
  6. ncbi request reprint Co-administration of opioid agonists and antagonists in addiction and pain medicine
    Francesco Leri
    University of Guelph, Department of Psychology, 50 Stone Road East, Guelph, Ontario, N1G 2W1, Canada
    Expert Opin Pharmacother 9:1387-96. 2008
    ..However, repeated exposure to these drugs can lead to the development of physiologic dependence and, in some individuals, to opioid addiction...
  7. ncbi request reprint Patterns of opioid and cocaine co-use: a descriptive study in a Canadian sample of untreated opioid-dependent individuals
    Francesco Leri
    Department of Psychology, College of Social and Applied Human Sciences, University of Guelph, ON, Canada
    Exp Clin Psychopharmacol 13:303-10. 2005
    ..These findings indicate that different individuals display different patterns of opioids and cocaine co-use...
  8. ncbi request reprint Effects of high-dose methadone maintenance on cocaine place conditioning, cocaine self-administration, and mu-opioid receptor mRNA expression in the rat brain
    Francesco Leri
    Department of Psychology, University of Guelph, Guelph, ON, Canada
    Neuropsychopharmacology 31:1462-74. 2006
    ....
  9. ncbi request reprint Ultra-low-dose naltrexone reduces the rewarding potency of oxycodone and relapse vulnerability in rats
    Francesco Leri
    Department of Psychology, University of Guelph Guelph, ON, Canada N1G 2W1
    Pharmacol Biochem Behav 82:252-62. 2005
    ..c.). In summary, this work shows that ultra-low-dose NTX co-treatment augments the locomotor effects of oxycodone as it enhances opioid analgesia, but reduces oxycodone's rewarding potency and subsequent vulnerability to relapse...
  10. ncbi request reprint Reconditioning of drug-related cues: a potential contributor to relapse after drug reexposure
    Francesco Leri
    Department of Psychology, University of Guelph, Guelph Ontario, N1G 2W1, Canada
    Pharmacol Biochem Behav 80:621-30. 2005
    ....
  11. ncbi request reprint Understanding polydrug use: review of heroin and cocaine co-use
    Francesco Leri
    Center for Studies in Behavioural Neurobiology, Concordia University, Montreal, Montreal, Canada
    Addiction 98:7-22. 2003
    ..Once clearly identified, pharmacological and neuroanatomical methods can be employed in self-administering laboratory animals to uncover the neurobiological correlates of specific patterns of co-use...
  12. ncbi request reprint The consequences of different "lapses" on relapse to heroin seeking in rats
    Francesco Leri
    Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, Canada
    Exp Clin Psychopharmacol 10:339-49. 2002
    ..Simple exposure to heroin, or to heroin-related stimuli, during the lapse had little effect on responding in the test for relapse...
  13. ncbi request reprint Effects of cocaine in rats exposed to heroin
    Francesco Leri
    Department of Psychology, University of Guelph, Canada
    Neuropsychopharmacology 28:2102-16. 2003
    ..In response to cocaine, however, DA activity in the Acb was significantly lower in rats withdrawn from the highest dose of heroin...
  14. pmc Heroin and cocaine co-use in a group of injection drug users in Montréal
    Francesco Leri
    Department of Psychology, University of Guelph, Guelph, Ont
    J Psychiatry Neurosci 29:40-7. 2004
    ..To describe the pattern of co-use of heroin and cocaine in individuals who were not receiving methadone maintenance treatment...
  15. ncbi request reprint Methadone maintenance reduces heroin- and cocaine-induced relapse without affecting stress-induced relapse in a rodent model of poly-drug use
    Francesco Leri
    Department of Psychology, University of Guelph, Guelph, Ontario, Canada
    Neuropsychopharmacology 29:1312-20. 2004
    ..These results suggest that although methadone maintenance may not reduce the direct stimulatory effects of cocaine, it has the potential to reduce both spontaneous and cocaine-primed cocaine-seeking behavior...
  16. doi request reprint The effects of acute and chronic steady state methadone on memory retrieval in rats
    Erin Cummins
    Department of Psychology, University of Guelph, Guelph, N1G 2W1, Ontario, Canada
    Psychopharmacology (Berl) 222:225-35. 2012
    ..Although widely prescribed to treat opioid addiction, little is known about the possible side effects of methadone on memory functions...
  17. doi request reprint Co-sensitivity to the incentive properties of palatable food and cocaine in rats; implications for co-morbid addictions
    Annemarie Levy
    Department of Psychology, University of Guelph, Ontario, Canada
    Addict Biol 18:763-73. 2013
    ..This supports the hypothesis that co-morbid food-drug addictions may result from a shared vulnerability to acquire behaviors motivated by strong incentives...
  18. doi request reprint Unreinforced responding during limited access to heroin self-administration
    Erin Cummins
    Department of Psychology, University of Guelph, Guelph ON, Canada N1G 2W1
    Pharmacol Biochem Behav 90:420-7. 2008
    ..This suggests that acquisition of heroin self-administration is regulated by a balance between drug effects that promote and limit heroin intake...
  19. doi request reprint Inactivation of the ventromedial prefrontal cortex mimics re-emergence of heroin seeking caused by heroin reconditioning
    Jelena Ovari
    Department of Psychology, University of Guelph, 50 Stone Road East, Ontario, Canada
    Neurosci Lett 444:52-5. 2008
    ..These results indicate that the vmPFC modulates expression of extinguished heroin seeking and suggest that prefrontal inhibitory mechanisms are involved in relapse to drug seeking...
  20. doi request reprint Effect of food restriction on cocaine locomotor sensitization in Sprague-Dawley rats: role of kappa opioid receptors
    Craig P Allen
    Department of Psychology, University of Guelph, 50 Stone Road East, Guelph, ON, Canada
    Psychopharmacology (Berl) 226:571-8. 2013
    ..The interaction between repeated cocaine exposure and food restriction on sensitization to the stimulatory effects of cocaine has not been characterized...
  21. doi request reprint Enhancing effect of heroin on social recognition learning in male Sprague-Dawley rats: modulation by heroin pre-exposure
    Annemarie Levy
    Department of Psychology, University of Guelph, Guelph, Ontario, Canada
    Psychopharmacology (Berl) 204:413-21. 2009
    ..There is evidence that pre-exposure to drugs of abuse can induce sensitization to several of their effects...
  22. doi request reprint Oxycodone dose-dependently imparts conditioned reinforcing properties to discrete sensory stimuli in rats
    Stephanie L Grella
    Department of Psychology, University of Guelph, 50 Stone Rd E, Guelph, ON, N1W 2G1, Canada
    Pharmacol Res 64:364-70. 2011
    ..Therefore, the intravenous conditioned reinforcement procedure appears a useful method to study how opioid drugs impart reinforcing value to discrete environmental stimuli...
  23. doi request reprint Effect of acute and repeated cocaine exposure on response matching capabilities of Sprague-Dawley rats responding for sucrose on concurrent schedules of reinforcement
    Craig P Allen
    Department of Psychology, University of Guelph, Guelph ON, Canada
    Pharmacol Biochem Behav 96:96-103. 2010
    ..These results suggest that prior exposure to cocaine can produce perseverative behavior even when animals are required to match two well-learned and rewarded response options. The implications for addictive behaviors are discussed...
  24. doi request reprint FAAH inhibitor, URB-597, promotes extinction and CB(1) antagonist, SR141716, inhibits extinction of conditioned aversion produced by naloxone-precipitated morphine withdrawal, but not extinction of conditioned preference produced by morphine in rats
    Laurie A Manwell
    Department of Psychology, University of Guelph, Guelph, ON N1G2W1, Canada
    Pharmacol Biochem Behav 94:154-62. 2009
    ..3). These data support previous reports that the eCB system selectively facilitates extinction of aversive memories. URB-597 may prove useful in targeting extinction of aversively motivated behaviours...
  25. ncbi request reprint Blockade of stress-induced but not cocaine-induced reinstatement by infusion of noradrenergic antagonists into the bed nucleus of the stria terminalis or the central nucleus of the amygdala
    Francesco Leri
    Center for Studies in Behavioral Neurobiology, Concordia University, H3G 1M8, Montreal, Quebec, Canada
    J Neurosci 22:5713-8. 2002
    ....
  26. doi request reprint Antidepressant-like effects of paroxetine are produced by lower doses than those which produce nausea
    Katharine J Tuerke
    University of Guelph, Ontario, Canada
    Pharmacol Biochem Behav 93:190-5. 2009
    ..The TR test may be beneficial for assessing the side effect of nausea in preclinical tests of new compounds...
  27. ncbi request reprint Reconditioning of heroin place preference requires the basolateral amygdala
    Zoe Rizos
    Department of Psychology, University of Guelph, Guelph Ontario, Canada, N1G 2W1
    Pharmacol Biochem Behav 82:300-5. 2005
    ..These results suggest that the BLA plays an important role in a putative learning process initiated by drug re-exposure which may underlie the process of relapse...
  28. doi request reprint Fos expression in mesocorticolimbic areas during heroin place conditioning
    Michael J M Honsberger
    Department of Psychology, University of Guelph, Guelph, Ontario, Canada
    Neuroreport 19:63-7. 2008
    ..It is concluded that the medial prefrontal cortex may be the neural site whereby neural representations of novel stimuli with motivational value are associated during associative learning...
  29. pmc Oral gavage in rats: animal welfare evaluation
    Patricia V Turner
    Department of Pathobiology, University of Guelph, Guelph, Canada
    J Am Assoc Lab Anim Sci 51:25-30. 2012
    ..We conclude that orogastric gavage of aqueous solutions at 5 mL/kg does not negatively affect the welfare of laboratory rats acclimated to handling...
  30. ncbi request reprint Effects of single compared with pair housing on hypothalamic-pituitary-adrenal axis activity and low-dose heroin place conditioning in adult male sprague-dawley rats
    Patricia V Turner
    Department of Pathobiology, University of Guelph, Guelph, Ontario, Canada
    J Am Assoc Lab Anim Sci 53:161-7. 2014
    ..Single housing can enhance both this effect and sensitivity to the stimulatory and rewarding actions of heroin after withdrawal. ..
  31. doi request reprint Effect of yohimbine stress on reacquisition of oxycodone seeking in rats
    Amanda T Campbell
    Department of Psychology, University of Guelph, 50 Stone Rd E, Guelph, ON, N1W 2G1, Canada
    Psychopharmacology (Berl) 222:247-55. 2012
    ..Stress, a powerful precipitant of drug seeking during abstinence, may also accelerate the return to pathological patterns of intake after initial instances of drug reuse...
  32. ncbi request reprint Reinstatement of conditioned reinforcing properties of cocaine-conditioned stimuli
    Benjamin Goddard
    Department of Psychology, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Pharmacol Biochem Behav 83:540-6. 2006
    ..These findings suggest that cocaine primes and stress can induce reinstatement by reactivating the motivational value of cocaine-conditioned cues...
  33. doi request reprint Excitotoxic lesions to the prefrontal cortex of Sprague-Dawley rats do not impair response matching
    Craig P Allen
    Department of Psychology, University of Guelph, Guelph, ON, Canada
    Neurosci Lett 495:30-4. 2011
    ..When animals were re-tested post-surgery, no significant impairments were found. These results indicate that, in trained rats, the PFC is not necessary for selecting responses on the basis of favorable effort-to-reward contingencies...
  34. doi request reprint Cue-induced renewal of heroin place preference: involvement of the basolateral amygdala
    Erin Cummins
    Department of Psychology, University of Guelph, Guelph, Ontario, Canada
    Neuroreport 25:297-302. 2014
    ..3 nmol) just prior to the test. These data suggest that an extinguished heroin place preference can be renewed by a contextual tactual stimulus that was part of the conditioning context, and that this process requires an intact BLA. ..
  35. pmc Nitric oxide and histone deacetylases modulate cocaine-induced mu-opioid receptor levels in PC12 cells
    Warren Winick-Ng
    Department of Biomedical Sciences, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
    BMC Pharmacol Toxicol 13:11. 2012
    ..Cocaine exposure has been reported to alter central μ-opioid receptor (MOR) expression in vivo. The present study employed an in vitro cellular model to explore possible mechanisms that may be involved in this action of cocaine...
  36. doi request reprint Perseveration in the presence of punishment: the effects of chronic cocaine exposure and lesions to the prefrontal cortex
    Craig P Allen
    Department of Psychology, University of Guelph, Guelph, ON, Canada
    Behav Brain Res 261:185-92. 2014
    ....
  37. doi request reprint Animal studies trigger new insights on the use of methadone maintenance
    Erin Cummins
    PhD Student University of Guelph, Department of Psychology, Guelph ON, N1G 2W1, Canada
    Expert Opin Drug Discov 4:577-86. 2009
    ..These findings suggest that SSM could be an effective pharmacological agent to assist cocaine detoxification and prevention of relapse to cocaine abuse in individuals not co-dependent on opioid...
  38. ncbi request reprint Using latent class analysis (LCA) to analyze patterns of drug use in a population of illegal opioid users
    Neerav Monga
    Centre for Addiction and Mental Health, Toronto, Ontario M5S 2S1, Canada
    Drug Alcohol Depend 88:1-8. 2007
    ..The objective of this paper is to empirically determine a categorization of illegal opioid users in Canada in order to describe and analyze drug use patterns within this population...
  39. ncbi request reprint Involvement of arginine vasopressin and V1b receptor in heroin withdrawal and heroin seeking precipitated by stress and by heroin
    Yan Zhou
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10021, USA
    Neuropsychopharmacology 33:226-36. 2008
    ....