F H Leenen


Affiliation: University of Ottawa Heart Institute
Country: Canada


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    Leenen F, Yuan B. Prevention of hypertension by irbesartan in Dahl S rats relates to central angiotensin II type 1 receptor blockade. Hypertension. 2001;37:981-4 pubmed
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    Leenen F, Coletta E, Fourney A, White R. Aging and cardiac responses to epinephrine in humans: role of neuronal uptake. Am J Physiol Heart Circ Physiol. 2005;288:H2498-503 pubmed
  3. Leenen F, Hou X, Wang H, Ahmad M. Enhanced expression of epithelial sodium channels causes salt-induced hypertension in mice through inhibition of the α2-isoform of Na+, K+-ATPase. Physiol Rep. 2015;3: pubmed publisher
    ..These findings substantiate the concept that enhanced ENaC activity causes salt-induced pressor responses mainly through EO inhibiting the α2-isoform of Na(+), K(+)-ATPase in the brain. ..
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    Leenen F, Yuan B. Mortality after coronary artery occlusion in different models of cardiac hypertrophy in rats. Hypertension. 2001;37:209-15 pubmed
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    Leenen F, Nwachuku C, Black H, Cushman W, Davis B, Simpson L, et al. Clinical events in high-risk hypertensive patients randomly assigned to calcium channel blocker versus angiotensin-converting enzyme inhibitor in the antihypertensive and lipid-lowering treatment to prevent heart attack trial. Hypertension. 2006;48:374-84 pubmed
    ..Some, but not all, of these differences may be explained by less effective blood pressure control in the lisinopril arm. ..
  6. Rafatian N, Westcott K, White R, Leenen F. Cardiac macrophages and apoptosis after myocardial infarction: effects of central MR blockade. Am J Physiol Regul Integr Comp Physiol. 2014;307:R879-87 pubmed publisher
    ..These findings indicate that MR activation in the brain enhances apoptosis both in myocytes and nonmyocytes in the peri-infarct and infarct area post-MI and contributes to the inflammatory response. ..
  7. Leenen F. The central role of the brain aldosterone-"ouabain" pathway in salt-sensitive hypertension. Biochim Biophys Acta. 2010;1802:1132-9 pubmed publisher
  8. Wang H, Huang B, Chen A, Ahmad M, White R, Leenen F. Role of brain aldosterone and mineralocorticoid receptors in aldosterone-salt hypertension in rats. Neuroscience. 2016;314:90-105 pubmed publisher
    ..This central aldosterone-MR-AT1R neuro-modulatory pathway appears to play a major role in the progressive hypertension. ..
  9. Shehata M, Leenen F, Tesson F. Sequence analysis of coding and 3' and 5' flanking regions of the epithelial sodium channel alpha, beta, and gamma genes in Dahl S versus R rats. BMC Genet. 2007;8:35 pubmed

More Information


  1. Wang H, Huang B, White R, Chen A, Ahmad M, Leenen F. Mineralocorticoid and angiotensin II type 1 receptors in the subfornical organ mediate angiotensin II - induced hypothalamic reactive oxygen species and hypertension. Neuroscience. 2016;329:112-21 pubmed publisher
    ..Activation of Aldo-MR signaling from the SFO to the SON may enhance AT1R dependent activation of pre-sympathetic neurons in the PVN. ..
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    Leenen F, White R, Yuan B. Isoproterenol-induced cardiac hypertrophy: role of circulatory versus cardiac renin-angiotensin system. Am J Physiol Heart Circ Physiol. 2001;281:H2410-6 pubmed
    ..These findings do not support a role for the circulatory or cardiac RAS in the cardiac trophic responses to beta-receptor stimulation...
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    Leenen F, Ruzicka M, Huang B. The brain and salt-sensitive hypertension. Curr Hypertens Rep. 2002;4:129-35 pubmed
  4. Leenen F, Blaustein M, Hamlyn J. Update on angiotensin II: new endocrine connections between the brain, adrenal glands and the cardiovascular system. Endocr Connect. 2017;6:R131-R145 pubmed publisher