F H Leenen
Affiliation: University of Ottawa Heart Institute
Leenen F, Yuan B. Prevention of hypertension by irbesartan in Dahl S rats relates to central angiotensin II type 1 receptor blockade. Hypertension. 2001;37:981-4 pubmed
Leenen F, Coletta E, Fourney A, White R. Aging and cardiac responses to epinephrine in humans: role of neuronal uptake. Am J Physiol Heart Circ Physiol. 2005;288:H2498-503 pubmed
Leenen F, Hou X, Wang H, Ahmad M. Enhanced expression of epithelial sodium channels causes salt-induced hypertension in mice through inhibition of the Î±2-isoform of Na+, K+-ATPase. Physiol Rep. 2015;3: pubmed publisher
..These findings substantiate the concept that enhanced ENaC activity causes salt-induced pressor responses mainly through EO inhibiting the Î±2-isoform of Na(+), K(+)-ATPase in the brain. ..
Leenen F, Yuan B. Mortality after coronary artery occlusion in different models of cardiac hypertrophy in rats. Hypertension. 2001;37:209-15 pubmed
Leenen F, Nwachuku C, Black H, Cushman W, Davis B, Simpson L, et al
. Clinical events in high-risk hypertensive patients randomly assigned to calcium channel blocker versus angiotensin-converting enzyme inhibitor in the antihypertensive and lipid-lowering treatment to prevent heart attack trial. Hypertension. 2006;48:374-84 pubmed
..Some, but not all, of these differences may be explained by less effective blood pressure control in the lisinopril arm. ..
Rafatian N, Westcott K, White R, Leenen F. Cardiac macrophages and apoptosis after myocardial infarction: effects of central MR blockade. Am J Physiol Regul Integr Comp Physiol. 2014;307:R879-87 pubmed publisher
..These findings indicate that MR activation in the brain enhances apoptosis both in myocytes and nonmyocytes in the peri-infarct and infarct area post-MI and contributes to the inflammatory response. ..
Leenen F. The central role of the brain aldosterone-"ouabain" pathway in salt-sensitive hypertension. Biochim Biophys Acta. 2010;1802:1132-9 pubmed publisher
Wang H, Huang B, Chen A, Ahmad M, White R, Leenen F. Role of brain aldosterone and mineralocorticoid receptors in aldosterone-salt hypertension in rats. Neuroscience. 2016;314:90-105 pubmed publisher
..This central aldosterone-MR-AT1R neuro-modulatory pathway appears to play a major role in the progressive hypertension. ..
Shehata M, Leenen F, Tesson F. Sequence analysis of coding and 3' and 5' flanking regions of the epithelial sodium channel alpha, beta, and gamma genes in Dahl S versus R rats. BMC Genet. 2007;8:35 pubmed