W Wayne Lautt

Summary

Affiliation: University of Manitoba
Country: Canada

Publications

  1. ncbi Should clinical cardiologists report total peripheral resistance or total peripheral conductance?
    W W Lautt
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, Winnipeg
    Can J Cardiol 15:45-7. 1999
  2. doi Bethanechol and N-acetylcysteine mimic feeding signals and reverse insulin resistance in fasted and sucrose-induced diabetic rats
    W Wayne Lautt
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, 753 McDermot Avenue, Winnipeg, Manitoba, Canada
    Can J Physiol Pharmacol 89:135-42. 2011
  3. ncbi The HISS story overview: a novel hepatic neurohumoral regulation of peripheral insulin sensitivity in health and diabetes
    W W Lautt
    Department of Pharmacology and Therapeutics, Faculty of Medicine, The University of Manitoba, Winnipeg, Canada
    Can J Physiol Pharmacol 77:553-62. 1999
  4. ncbi Hepatic parasympathetic (HISS) control of insulin sensitivity determined by feeding and fasting
    W W Lautt
    Faculty of Medicine, Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Manitoba, Canada R3E OW3
    Am J Physiol Gastrointest Liver Physiol 281:G29-36. 2001
  5. pmc Attenuation of age- and sucrose-induced insulin resistance and syndrome X by a synergistic antioxidant cocktail: the AMIS syndrome and HISS hypothesis
    W Wayne Lautt
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, 753 McDermot Avenue, Winnipeg, MB R3E 0T6, Canada
    Can J Physiol Pharmacol 88:313-23. 2010
  6. ncbi Practice and principles of pharmacodynamic determination of HISS-dependent and HISS-independent insulin action: methods to quantitate mechanisms of insulin resistance
    W Wayne Lautt
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, A210 753 McDermot Avenue, Winnipeg, Manitoba, Canada, R3E 0T6
    Med Res Rev 23:1-14. 2003
  7. pmc HISS-dependent insulin resistance (HDIR) in aged rats is associated with adiposity, progresses to syndrome X, and is attenuated by a unique antioxidant cocktail
    W Wayne Lautt
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, Winnipeg, Man, Canada R3E 0T6
    Exp Gerontol 43:790-800. 2008
  8. ncbi Pharmaceutical reversal of insulin resistance
    W Wayne Lautt
    Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Manitoba, Canada
    Proc West Pharmacol Soc 47:30-2. 2004
  9. doi Obesity, syndrome X, and diabetes: the role of HISS-dependent insulin resistance altered by sucrose, an antioxidant cocktail, and age
    Zhi Ming
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, 753 McDermot Avenue, Winnipeg, MB R3E 0T6, Canada
    Can J Physiol Pharmacol 87:873-82. 2009
  10. ncbi Intrahepatic adenosine-mediated activation of hepatorenal reflex is via A1 receptors in rats
    Zhi Ming
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, 753 McDermot Avenue, Winnipeg, MB R3E 0T6, Canada
    Can J Physiol Pharmacol 84:1177-84. 2006

Collaborators

Detail Information

Publications45

  1. ncbi Should clinical cardiologists report total peripheral resistance or total peripheral conductance?
    W W Lautt
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, Winnipeg
    Can J Cardiol 15:45-7. 1999
    ....
  2. doi Bethanechol and N-acetylcysteine mimic feeding signals and reverse insulin resistance in fasted and sucrose-induced diabetic rats
    W Wayne Lautt
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, 753 McDermot Avenue, Winnipeg, Manitoba, Canada
    Can J Physiol Pharmacol 89:135-42. 2011
    ..Neither was effective alone. Both "feeding signals" are necessary and sufficient for insulin to stimulate HISS release...
  3. ncbi The HISS story overview: a novel hepatic neurohumoral regulation of peripheral insulin sensitivity in health and diabetes
    W W Lautt
    Department of Pharmacology and Therapeutics, Faculty of Medicine, The University of Manitoba, Winnipeg, Canada
    Can J Physiol Pharmacol 77:553-62. 1999
    ..Possible relevance of this HISS-dependent control of insulin action to insulin resistance in diabetes, liver disease, and obesity is discussed...
  4. ncbi Hepatic parasympathetic (HISS) control of insulin sensitivity determined by feeding and fasting
    W W Lautt
    Faculty of Medicine, Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Manitoba, Canada R3E OW3
    Am J Physiol Gastrointest Liver Physiol 281:G29-36. 2001
    ..We also tested the hypothesis that HISS release is controlled by the feed/fast status. Feeding resulted in maximal HISS action, which decreased progressively with the duration of fasting...
  5. pmc Attenuation of age- and sucrose-induced insulin resistance and syndrome X by a synergistic antioxidant cocktail: the AMIS syndrome and HISS hypothesis
    W Wayne Lautt
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, 753 McDermot Avenue, Winnipeg, MB R3E 0T6, Canada
    Can J Physiol Pharmacol 88:313-23. 2010
    ..AMIS is explained by the HISS (hepatic insulin-sensitizing substance) hypothesis, which is outlined in the paper...
  6. ncbi Practice and principles of pharmacodynamic determination of HISS-dependent and HISS-independent insulin action: methods to quantitate mechanisms of insulin resistance
    W Wayne Lautt
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, A210 753 McDermot Avenue, Winnipeg, Manitoba, Canada, R3E 0T6
    Med Res Rev 23:1-14. 2003
    ..The RIST can be carried out up to six times in the same animal, is not affected by pentobarbital anesthesia, and can readily differentiate HISS-dependent and HISS-independent insulin action...
  7. pmc HISS-dependent insulin resistance (HDIR) in aged rats is associated with adiposity, progresses to syndrome X, and is attenuated by a unique antioxidant cocktail
    W Wayne Lautt
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, Winnipeg, Man, Canada R3E 0T6
    Exp Gerontol 43:790-800. 2008
    ..Data are consistent with the hypotheses. Early detection and therapy directed towards treatment of HDIR offers a novel therapeutic target...
  8. ncbi Pharmaceutical reversal of insulin resistance
    W Wayne Lautt
    Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Manitoba, Canada
    Proc West Pharmacol Soc 47:30-2. 2004
    ..The MIS process has now been demonstrated in mice, rats, guinea pigs, cats, dogs, and humans, and has been demonstrated by independent laboratories...
  9. doi Obesity, syndrome X, and diabetes: the role of HISS-dependent insulin resistance altered by sucrose, an antioxidant cocktail, and age
    Zhi Ming
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, 753 McDermot Avenue, Winnipeg, MB R3E 0T6, Canada
    Can J Physiol Pharmacol 87:873-82. 2009
    ....
  10. ncbi Intrahepatic adenosine-mediated activation of hepatorenal reflex is via A1 receptors in rats
    Zhi Ming
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, 753 McDermot Avenue, Winnipeg, MB R3E 0T6, Canada
    Can J Physiol Pharmacol 84:1177-84. 2006
    ..In conclusion, intrahepatic adenosine A1 receptors are responsible for the adenosine-mediated hepatorenal reflex that regulates renal water and sodium excretion...
  11. ncbi Acute hemorrhage causes hepatic insulin sensitizing substance (HISS)-dependent insulin resistance
    Larissa I Seredycz
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, A210 753 McDermot Avenue, Winnipeg, MB R3E 0T6, Canada
    Can J Physiol Pharmacol 84:1145-51. 2006
    ..HDIR represents a useful hormonal response to assure a hyperglycemic response to hemorrhage...
  12. doi Insulin sensitization by voluntary exercise in aging rats is mediated through hepatic insulin sensitizing substance (HISS)
    Kawshik K Chowdhury
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, 753 McDermot Avenue, Winnipeg, MB R3E 0T6, Canada
    Exp Gerontol 46:73-80. 2011
    ..HISS release decreases with age, and exercise causes metabolic improvements in aging, therefore it is important to analyze the effect of exercise on age-associated decline in HISS-action...
  13. ncbi Insulin sensitivity in skeletal muscle regulated by a hepatic hormone, HISS
    W Wayne Lautt
    Dept of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, 753 McDermot Ave, Winnipeg, Manitoba, Canada
    Can J Appl Physiol 30:304-12. 2005
    ..It is suggested that HISS-dependent insulin resistance occurs in animal models including sucrose-fed rats, spontaneously hypertensive rats, chronic liver disease, fetal alcohol effect in the adult offspring, and type 2 diabetes...
  14. ncbi Contribution of hepatic adenosine A1 receptors to renal dysfunction associated with acute liver injury in rats
    Zhi Ming
    Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Manitoba, Canada
    Hepatology 44:813-22. 2006
    ..In conclusion, an activated hepatorenal reflex, triggered by intrahepatic adenosine A(1) receptors, contributed to the pathogenesis of the water and sodium retention associated with acute liver injury...
  15. doi Acetylcholinesterase antagonist potentiated insulin action in fed but not fasted state
    Joshua Schafer
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    J Pharmacol Exp Ther 333:621-8. 2010
    ..No potentiation of the response to insulin by neostigmine occurred in normal, fed rats. The data suggest the use of either direct or indirectly acting cholinergic agonists for the treatment of impaired postprandial insulin sensitization...
  16. doi Lifestyle impact on meal-induced insulin sensitization in health and prediabetes: a focus on diet, antioxidants, and exercise interventions
    Kawshik K Chowdhury
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, A210 753 McDermot Avenue, Winnipeg, MB R3E 0T6, Canada
    Can J Physiol Pharmacol 91:91-100. 2013
    ..High fat or sugar supplemented diet reduces MIS; exercise elevates MIS; and antioxidants protect MIS against reductions associated with diet and age...
  17. ncbi Insulin sensitivity regulated by feeding in the conscious unrestrained rat
    Martin G Latour
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
    Can J Physiol Pharmacol 80:8-12. 2002
    ..Re-feeding fasted rats reversed HISS-dependent insulin resistance. Merits of use of the RIST in conscious versus anesthetized rats are discussed...
  18. ncbi Increased incidence of hepatic insulin-sensitizing substance (HISS)-dependent insulin resistance in female rats prenatally exposed to ethanol
    Parissa Sadri
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
    Can J Physiol Pharmacol 83:383-7. 2005
    ..The results are consistent with the hypothesis that adult-female offspring are more severely affected by in utero ethanol exposure compared with adult-male offspring...
  19. ncbi Blockade of intrahepatic adenosine receptors improves urine excretion in cirrhotic rats induced by thioacetamide
    Zhi Ming
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, A210 753 McDermot Avenue, Winnipeg, Man, Canada
    J Hepatol 42:680-6. 2005
    ..We hypothesize that the impaired urine excretion in liver cirrhosis is related to an increase in intrahepatic adenosine...
  20. doi Absence of meal-induced insulin sensitization (AMIS) in aging rats is associated with cardiac dysfunction that is protected by antioxidants
    Zhi Ming
    Dept of Pharmacology and Therapeutics, Faculty of Medicine, Univ of Manitoba, Winnipeg, MB R3E0T6, Canada
    J Appl Physiol (1985) 111:704-14. 2011
    ..These results indicate that AMIS is the first metabolic defect that leads to homeostatic disturbances and dysfunctions, including cardiovascular diseases...
  21. doi Exercise enhancement of hepatic insulin-sensitising substance-mediated glucose uptake in diet-induced prediabetic rats
    Kawshik K Chowdhury
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, A210 753 McDermot Avenue, Winnipeg, Canada MB R3E 0T6
    Br J Nutr 109:844-52. 2013
    ..Exercise improves insulin sensitivity in diet-induced insulin resistance primarily by restoration of HISS-mediated glucose uptake...
  22. pmc Synergistic protection by S-adenosylmethionine with vitamins C and E on liver injury induced by thioacetamide in rats
    Zhi Ming
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada R3E 0W3
    Free Radic Biol Med 40:617-24. 2006
    ..There are synergistic antioxidative effects among the antioxidants, SAMe and vitamins C and E, that protect the liver from TAA-induced HDIR, suggesting that antioxidant treatment may best be done using a balanced "cocktail."..
  23. doi Caffeine-induced natriuresis and diuresis via blockade of hepatic adenosine-mediated sensory nerves and a hepatorenal reflex
    Zhi Ming
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, A210 753 McDermot Avenue, Winnipeg, MB R3E 0W3, Canada
    Can J Physiol Pharmacol 88:1115-21. 2010
    ..The liver-dependent diuretic effect of caffeine is consistent with the hypothesis for the adenosine-mediated mechanism of hepatorenal syndrome...
  24. pmc The role of prostaglandins in triggering the liver regeneration cascade
    Jodi M Schoen Smith
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada R3E 0T6
    Nitric Oxide 13:111-7. 2005
    ..This suggests that exogenous NO and/or PGs may play a role in potentiation of the liver regeneration cascade...
  25. ncbi Pattern of insulin delivery affects hepatic insulin sensitizing substance (HISS) action and insulin resistance
    Maria A G Reid
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, A210 753 McDermot Avenue, Winnipeg, Manitoba R3E 0T6, Canada
    Can J Physiol Pharmacol 82:1068-74. 2004
    ..Continuous insulin infusion (10-30 min) showed progressive postinfusion blockade of HISS action. To maintain HISS-dependent insulin action, continuous insulin infusions should be avoided...
  26. doi HISS, not insulin, causes vasodilation in response to administered insulin
    Zhi Ming
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of anitoba, Winnipeg, Manitoba, Canada
    J Appl Physiol (1985) 110:60-8. 2011
    ..These studies report vascular actions of HISS for the first time and demonstrate that HISS, not insulin action, results in the peripheral vasodilation generally attributed to insulin...
  27. ncbi Hemorrhage results in hepatic insulin-sensitizing substance-dependent insulin resistance mediated by somatostatin in rats
    Larissa I Seredycz
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
    Neuroendocrinology 84:94-102. 2006
    ..Blockade of HISS action secondary to blood loss leads to a state known as HISS-dependent insulin resistance (HDIR) which results in a decrease in the glucose disposal action of insulin by 33 +/- 3%...
  28. pmc Nitric oxide and prostaglandins potentiate the liver regeneration cascade
    Jodi M Schoen Smith
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, Winnipeg
    Can J Gastroenterol 20:329-34. 2006
    ..These results also provide support for the hypothesis that NO and PGs are possible therapeutic targets to potentiate liver regeneration following surgical resection...
  29. ncbi The effect of acute, chronic, and prenatal ethanol exposure on insulin sensitivity
    Justin W Ting
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, A210 753 McDermot Avenue, Winnipeg, Manitoba, Canada R3E 0T6
    Pharmacol Ther 111:346-73. 2006
    ..The impaired HISS release may be related to a reduction in hepatic glutathione (GSH) levels. The effect of chronic ethanol consumption on HISS has not been evaluated...
  30. ncbi Reflex regulation by portal blood flow on renal function in healthy and cirrhotic rats: role of adenosine--a conceptual overview
    Zhi Ming
    Department of Pharmacology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Proc West Pharmacol Soc 47:33-4. 2004
  31. ncbi Comparison of the rapid insulin sensitivity test (RIST), the insulin tolerance test (ITT), and the hyperinsulinemic euglycemic clamp (HIEC) to measure insulin action in rats
    Maria A G Reid
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
    Can J Physiol Pharmacol 80:811-8. 2002
    ....
  32. ncbi The hepatic vagus nerve in the control of insulin sensitivity in the rat
    Martin G Latour
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
    Auton Neurosci 95:125-30. 2002
    ..This approach provides an additional research tool to study the hepatic parasympathetic reflex control of peripheral insulin action...
  33. ncbi New paradigm for the mechanism and treatment of insulin resistance
    W Wayne Lautt
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba R3E 0T6, Canada
    Proc West Pharmacol Soc 45:223-4. 2002
  34. ncbi Regulation of cardiac mitochondrial monolysocardiolipin acyltransferase activity and expression during development and in fetal alcohol syndrome
    William A Taylor
    Department of Pharmacology and Therapeutics, Center for Research and Treatment of Atherosclerosis, University of Manitoba, Winnipeg, Manitoba, Canada
    Proc West Pharmacol Soc 50:115-8. 2007
    ....
  35. ncbi A new paradigm for diabetes and obesity: the hepatic insulin sensitizing substance (HISS) hypothesis
    W Wayne Lautt
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
    J Pharmacol Sci 95:9-17. 2004
    ..New diagnostic approaches and therapeutic targets are described...
  36. ncbi Shear stress-induced nitric oxide release triggers the liver regeneration cascade
    J M Schoen
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, 753 McDermot Avenue, Winnipeg, Manitoba R3E 0W3, Canada
    Nitric Oxide 5:453-64. 2001
    ..These results provide support for the hypothesis that a hemodynamic change results in increased shear stress in the liver causing generation of NO, which then triggers the liver regeneration cascade...
  37. doi Interaction of antioxidants and exercise on insulin sensitivity in healthy and prediabetic rats
    Kawshik K Chowdhury
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, A210 753 McDermot Avenue, Winnipeg, MB R3E 0T6, Canada
    Can J Physiol Pharmacol 91:570-7. 2013
    ..While SAMEC alone was a demonstrated preventive against the progressive loss of HISS action in previous studies, short-term supplementation in this study did not reverse the established disease state. ..
  38. ncbi A preliminary investigation of the effects of maternal ethanol intake during gestation and lactation on brain adenosine A(1) receptor expression in rat offspring
    Timothy Othman
    Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, MB, Canada
    Neurotoxicol Teratol 24:275-9. 2002
    ..These preliminary findings indicate that ethanol intake by dams during pregnancy and lactation can affect adenosine A1 receptor signalling in the offspring. A pair-fed controlled study is warranted to explore these findings further...
  39. ncbi Decreases in portal flow trigger a hepatorenal reflex to inhibit renal sodium and water excretion in rats: role of adenosine
    Zhi Ming
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Hepatology 35:167-75. 2002
    ..The water and sodium retention commonly seen in the hepatorenal syndrome may be related to intrahepatic adenosine accumulation resulting from the associated decrease in intrahepatic portal flow...
  40. ncbi Nitric oxide potentiates C-Fos mRNA expression after 2/3 partial hepatectomy
    Jodi M Schoen
    Department of Pharmacology and Therapeutics, University of Manitoba, 753 McDermot Avenue, Winnipeg, MB, R3E 0T6, Canada
    Proc West Pharmacol Soc 45:47-8. 2002
  41. ncbi Effects of the liver on circulating adenosine in blood
    Y Zhang
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
    Can J Physiol Pharmacol 71:874-8. 1993
    ..Dilazep inhibits extrahepatic elimination but does not affect hepatic extraction of circulating adenosine. Subtypes of nucleoside uptake are suggested to exist between the liver and other cell types, such as red blood cells...
  42. ncbi Intrahepatic adenosine triggers a hepatorenal reflex to regulate renal sodium and water excretion
    Z Ming
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
    Auton Neurosci 93:1-7. 2001
    ..The water and sodium retention commonly seen in the hepatorenal syndrome may be related to intraportal adenosine accumulation due to the decrease in intraportal portal flow...
  43. ncbi Insulin resistance in two animal models of obesity: A comparison of HISS-dependent and HISS-independent insulin action in high-fat diet-fed and Zucker rats
    Ricardo Alexandre Afonso
    Department of Biochemistry, Faculty of Medical Sciences, New University of Lisbon, Portugal
    Proc West Pharmacol Soc 50:110-4. 2007
    ....
  44. ncbi A new technique to assess insulin sensitivity in humans: the rapid insulin sensitivity test (RIST)
    Rita S Patarrao
    Department of Biochemistry, Faculty of Medical Sciences, New University of Lisbon, Lisbon, Portugal
    Proc West Pharmacol Soc 50:105-9. 2007
    ..The RIST is a powerful research tool to assess the glucose utilization action of an insulin bolus in fasted and fed states both evaluated in the same day...
  45. ncbi Insulin sensitivity is mediated by the activation of the ACh/NO/cGMP pathway in rat liver
    Maria P Guarino
    Faculty of Medical Sciences, Department of Physiology, New University of Lisbon, 1169 056 Lisbon, Portugal
    Am J Physiol Gastrointest Liver Physiol 287:G527-32. 2004
    ..6 +/- 18.6 mg glucose/kg; RIST post-ODQ 111.7 +/- 6.2 mg glucose/kg, n = 5). We propose that hepatic parasympathetic nerves release ACh, leading to hepatic NO synthesis, which activates GC, triggering HISS action...