Research Topics
| W Wayne LauttSummaryAffiliation: University of Manitoba Country: Canada Publications
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Publications
Should clinical cardiologists report total peripheral resistance or total peripheral conductance?W W Lautt
Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, Winnipeg
Can J Cardiol 15:45-7. 1999....
Bethanechol and N-acetylcysteine mimic feeding signals and reverse insulin resistance in fasted and sucrose-induced diabetic ratsW Wayne Lautt
Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, 753 McDermot Avenue, Winnipeg, Manitoba, Canada
Can J Physiol Pharmacol 89:135-42. 2011..Neither was effective alone. Both "feeding signals" are necessary and sufficient for insulin to stimulate HISS release...- Pharmaceutical reversal of insulin resistanceW Wayne Lautt
Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Manitoba, Canada
Proc West Pharmacol Soc 47:30-2. 2004..The MIS process has now been demonstrated in mice, rats, guinea pigs, cats, dogs, and humans, and has been demonstrated by independent laboratories... - Practice and principles of pharmacodynamic determination of HISS-dependent and HISS-independent insulin action: methods to quantitate mechanisms of insulin resistanceW Wayne Lautt
Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, A210 753 McDermot Avenue, Winnipeg, Manitoba, Canada, R3E 0T6
Med Res Rev 23:1-14. 2003..The RIST can be carried out up to six times in the same animal, is not affected by pentobarbital anesthesia, and can readily differentiate HISS-dependent and HISS-independent insulin action... 
HISS-dependent insulin resistance (HDIR) in aged rats is associated with adiposity, progresses to syndrome X, and is attenuated by a unique antioxidant cocktailW Wayne Lautt
Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, Winnipeg, Man, Canada R3E 0T6
Exp Gerontol 43:790-800. 2008..Data are consistent with the hypotheses. Early detection and therapy directed towards treatment of HDIR offers a novel therapeutic target...- Attenuation of age- and sucrose-induced insulin resistance and syndrome X by a synergistic antioxidant cocktail: the AMIS syndrome and HISS hypothesisW Wayne Lautt
Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, 753 McDermot Avenue, Winnipeg, MB R3E 0T6, Canada
Can J Physiol Pharmacol 88:313-23. 2010..AMIS is explained by the HISS (hepatic insulin-sensitizing substance) hypothesis, which is outlined in the paper... - The HISS story overview: a novel hepatic neurohumoral regulation of peripheral insulin sensitivity in health and diabetesW W Lautt
Department of Pharmacology and Therapeutics, Faculty of Medicine, The University of Manitoba, Winnipeg, Canada
Can J Physiol Pharmacol 77:553-62. 1999..Possible relevance of this HISS-dependent control of insulin action to insulin resistance in diabetes, liver disease, and obesity is discussed... - Hepatic parasympathetic (HISS) control of insulin sensitivity determined by feeding and fastingW W Lautt
Faculty of Medicine, Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Manitoba, Canada R3E OW3
Am J Physiol Gastrointest Liver Physiol 281:G29-36. 2001..We also tested the hypothesis that HISS release is controlled by the feed/fast status. Feeding resulted in maximal HISS action, which decreased progressively with the duration of fasting... - Obesity, syndrome X, and diabetes: the role of HISS-dependent insulin resistance altered by sucrose, an antioxidant cocktail, and ageZhi Ming
Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, 753 McDermot Avenue, Winnipeg, MB R3E 0T6, Canada
Can J Physiol Pharmacol 87:873-82. 2009.... - Intrahepatic adenosine-mediated activation of hepatorenal reflex is via A1 receptors in ratsZhi Ming
Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, 753 McDermot Avenue, Winnipeg, MB R3E 0T6, Canada
Can J Physiol Pharmacol 84:1177-84. 2006..In conclusion, intrahepatic adenosine A1 receptors are responsible for the adenosine-mediated hepatorenal reflex that regulates renal water and sodium excretion... - Acute hemorrhage causes hepatic insulin sensitizing substance (HISS)-dependent insulin resistanceLarissa I Seredycz
Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, A210-753 McDermot Avenue, Winnipeg, MB R3E 0T6, Canada
Can J Physiol Pharmacol 84:1145-51. 2006..HDIR represents a useful hormonal response to assure a hyperglycemic response to hemorrhage... - Insulin sensitization by voluntary exercise in aging rats is mediated through hepatic insulin sensitizing substance (HISS)Kawshik K Chowdhury
Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, 753 McDermot Avenue, Winnipeg, MB R3E 0T6, Canada
Exp Gerontol 46:73-80. 2011..HISS release decreases with age, and exercise causes metabolic improvements in aging, therefore it is important to analyze the effect of exercise on age-associated decline in HISS-action... - Insulin sensitivity in skeletal muscle regulated by a hepatic hormone, HISSW Wayne Lautt
Dept. of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, 753 McDermot Ave, Winnipeg, Manitoba, Canada
Can J Appl Physiol 30:304-12. 2005..It is suggested that HISS-dependent insulin resistance occurs in animal models including sucrose-fed rats, spontaneously hypertensive rats, chronic liver disease, fetal alcohol effect in the adult offspring, and type 2 diabetes... - Contribution of hepatic adenosine A1 receptors to renal dysfunction associated with acute liver injury in ratsZhi Ming
Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Manitoba, Canada
Hepatology 44:813-22. 2006..In conclusion, an activated hepatorenal reflex, triggered by intrahepatic adenosine A(1) receptors, contributed to the pathogenesis of the water and sodium retention associated with acute liver injury... - Acetylcholinesterase antagonist potentiated insulin action in fed but not fasted stateJoshua Schafer
Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
J Pharmacol Exp Ther 333:621-8. 2010..No potentiation of the response to insulin by neostigmine occurred in normal, fed rats. The data suggest the use of either direct or indirectly acting cholinergic agonists for the treatment of impaired postprandial insulin sensitization... - Absence of meal-induced insulin sensitization (AMIS) in aging rats is associated with cardiac dysfunction that is protected by antioxidantsZhi Ming
Dept of Pharmacology and Therapeutics, Faculty of Medicine, Univ of Manitoba, Winnipeg, MB R3E0T6, Canada
J Appl Physiol 111:704-14. 2011..These results indicate that AMIS is the first metabolic defect that leads to homeostatic disturbances and dysfunctions, including cardiovascular diseases... - Increased incidence of hepatic insulin-sensitizing substance (HISS)-dependent insulin resistance in female rats prenatally exposed to ethanolParissa Sadri
Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
Can J Physiol Pharmacol 83:383-7. 2005..The results are consistent with the hypothesis that adult-female offspring are more severely affected by in utero ethanol exposure compared with adult-male offspring... - Blockade of intrahepatic adenosine receptors improves urine excretion in cirrhotic rats induced by thioacetamideZhi Ming
Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, A210-753 McDermot Avenue, Winnipeg, Man, Canada
J Hepatol 42:680-6. 2005.... - Insulin sensitivity regulated by feeding in the conscious unrestrained ratMartin G Latour
Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
Can J Physiol Pharmacol 80:8-12. 2002..Re-feeding fasted rats reversed HISS-dependent insulin resistance. Merits of use of the RIST in conscious versus anesthetized rats are discussed... - Synergistic protection by S-adenosylmethionine with vitamins C and E on liver injury induced by thioacetamide in ratsZhi Ming
Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada R3E 0W3
Free Radic Biol Med 40:617-24. 2006..There are synergistic antioxidative effects among the antioxidants, SAMe and vitamins C and E, that protect the liver from TAA-induced HDIR, suggesting that antioxidant treatment may best be done using a balanced "cocktail.".. - The role of prostaglandins in triggering the liver regeneration cascadeJodi M Schoen Smith
Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada R3E 0T6
Nitric Oxide 13:111-7. 2005..This suggests that exogenous NO and/or PGs may play a role in potentiation of the liver regeneration cascade... - Caffeine-induced natriuresis and diuresis via blockade of hepatic adenosine-mediated sensory nerves and a hepatorenal reflexZhi Ming
Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, A210 753 McDermot Avenue, Winnipeg, MB R3E 0W3, Canada
Can J Physiol Pharmacol 88:1115-21. 2010..The liver-dependent diuretic effect of caffeine is consistent with the hypothesis for the adenosine-mediated mechanism of hepatorenal syndrome... - HISS, not insulin, causes vasodilation in response to administered insulinZhi Ming
Department of Pharmacology and Therapeutics, Faculty of Medicine, University of anitoba, Winnipeg, Manitoba, Canada
J Appl Physiol 110:60-8. 2011..These studies report vascular actions of HISS for the first time and demonstrate that HISS, not insulin action, results in the peripheral vasodilation generally attributed to insulin... - Pattern of insulin delivery affects hepatic insulin sensitizing substance (HISS) action and insulin resistanceMaria A G Reid
Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, A210-753 McDermot Avenue, Winnipeg, Manitoba R3E 0T6, Canada
Can J Physiol Pharmacol 82:1068-74. 2004..Continuous insulin infusion (10-30 min) showed progressive postinfusion blockade of HISS action. To maintain HISS-dependent insulin action, continuous insulin infusions should be avoided... - The effect of acute, chronic, and prenatal ethanol exposure on insulin sensitivityJustin W Ting
Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, A210-753 McDermot Avenue, Winnipeg, Manitoba, Canada R3E 0T6
Pharmacol Ther 111:346-73. 2006..The impaired HISS release may be related to a reduction in hepatic glutathione (GSH) levels. The effect of chronic ethanol consumption on HISS has not been evaluated... - Reflex regulation by portal blood flow on renal function in healthy and cirrhotic rats: role of adenosine--a conceptual overviewZhi Ming
Department of Pharmacology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
Proc West Pharmacol Soc 47:33-4. 2004 - Comparison of the rapid insulin sensitivity test (RIST), the insulin tolerance test (ITT), and the hyperinsulinemic euglycemic clamp (HIEC) to measure insulin action in ratsMaria A G Reid
Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
Can J Physiol Pharmacol 80:811-8. 2002.... - The hepatic vagus nerve in the control of insulin sensitivity in the ratMartin G Latour
Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
Auton Neurosci 95:125-30. 2002..This approach provides an additional research tool to study the hepatic parasympathetic reflex control of peripheral insulin action... - Hemorrhage results in hepatic insulin-sensitizing substance-dependent insulin resistance mediated by somatostatin in ratsLarissa I Seredycz
Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
Neuroendocrinology 84:94-102. 2006..Blockade of HISS action secondary to blood loss leads to a state known as HISS-dependent insulin resistance (HDIR) which results in a decrease in the glucose disposal action of insulin by 33 +/- 3%... - New paradigm for the mechanism and treatment of insulin resistanceW Wayne Lautt
Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba R3E 0T6, Canada
Proc West Pharmacol Soc 45:223-4. 2002 - Nitric oxide and prostaglandins potentiate the liver regeneration cascadeJodi M Schoen Smith
Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, Winnipeg
Can J Gastroenterol 20:329-34. 2006..These results also provide support for the hypothesis that NO and PGs are possible therapeutic targets to potentiate liver regeneration following surgical resection... - A new paradigm for diabetes and obesity: the hepatic insulin sensitizing substance (HISS) hypothesisW Wayne Lautt
Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
J Pharmacol Sci 95:9-17. 2004..New diagnostic approaches and therapeutic targets are described... - Regulation of cardiac mitochondrial monolysocardiolipin acyltransferase activity and expression during development and in fetal alcohol syndromeWilliam A Taylor
Department of Pharmacology and Therapeutics, Center for Research and Treatment of Atherosclerosis, University of Manitoba, Winnipeg, Manitoba, Canada
Proc West Pharmacol Soc 50:115-8. 2007.... - Shear stress-induced nitric oxide release triggers the liver regeneration cascadeJ M Schoen
Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, 753 McDermot Avenue, Winnipeg, Manitoba R3E 0W3, Canada
Nitric Oxide 5:453-64. 2001..These results provide support for the hypothesis that a hemodynamic change results in increased shear stress in the liver causing generation of NO, which then triggers the liver regeneration cascade... - Decreases in portal flow trigger a hepatorenal reflex to inhibit renal sodium and water excretion in rats: role of adenosineZhi Ming
Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
Hepatology 35:167-75. 2002..The water and sodium retention commonly seen in the hepatorenal syndrome may be related to intrahepatic adenosine accumulation resulting from the associated decrease in intrahepatic portal flow... - A preliminary investigation of the effects of maternal ethanol intake during gestation and lactation on brain adenosine A(1) receptor expression in rat offspringTimothy Othman
Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, MB, Canada
Neurotoxicol Teratol 24:275-9. 2002..These preliminary findings indicate that ethanol intake by dams during pregnancy and lactation can affect adenosine A1 receptor signalling in the offspring. A pair-fed controlled study is warranted to explore these findings further... - Nitric oxide potentiates C-Fos mRNA expression after 2/3 partial hepatectomyJodi M Schoen
Department of Pharmacology and Therapeutics, University of Manitoba, 753 McDermot Avenue, Winnipeg, MB, R3E 0T6, Canada
Proc West Pharmacol Soc 45:47-8. 2002 - Intrahepatic adenosine triggers a hepatorenal reflex to regulate renal sodium and water excretionZ Ming
Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
Auton Neurosci 93:1-7. 2001..The water and sodium retention commonly seen in the hepatorenal syndrome may be related to intraportal adenosine accumulation due to the decrease in intraportal portal flow... - Effects of the liver on circulating adenosine in bloodY Zhang
Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
Can J Physiol Pharmacol 71:874-8. 1993..Dilazep inhibits extrahepatic elimination but does not affect hepatic extraction of circulating adenosine. Subtypes of nucleoside uptake are suggested to exist between the liver and other cell types, such as red blood cells... - Insulin resistance in two animal models of obesity: A comparison of HISS-dependent and HISS-independent insulin action in high-fat diet-fed and Zucker ratsRicardo Alexandre Afonso
Department of Biochemistry, Faculty of Medical Sciences, New University of Lisbon, Portugal
Proc West Pharmacol Soc 50:110-4. 2007.... - Insulin sensitivity is mediated by the activation of the ACh/NO/cGMP pathway in rat liverMaria P Guarino
Faculty of Medical Sciences, Department of Physiology, New University of Lisbon, 1169-056 Lisbon, Portugal
Am J Physiol Gastrointest Liver Physiol 287:G527-32. 2004..6 +/- 18.6 mg glucose/kg; RIST post-ODQ 111.7 +/- 6.2 mg glucose/kg, n = 5). We propose that hepatic parasympathetic nerves release ACh, leading to hepatic NO synthesis, which activates GC, triggering HISS action... - A new technique to assess insulin sensitivity in humans: the rapid insulin sensitivity test (RIST)Rita S Patarrao
Department of Biochemistry, Faculty of Medical Sciences, New University of Lisbon, Lisbon, Portugal
Proc West Pharmacol Soc 50:105-9. 2007..The RIST is a powerful research tool to assess the glucose utilization action of an insulin bolus in fasted and fed states both evaluated in the same day...