K B Laupland

Summary

Affiliation: University of Calgary
Country: Canada

Publications

  1. doi request reprint Staphylococcus aureus bloodstream infections: risk factors, outcomes, and the influence of methicillin resistance in Calgary, Canada, 2000-2006
    Kevin B Laupland
    Department of Medicine, University of Calgary and Calgary Health Region, Calgary, Alberta, Canada
    J Infect Dis 198:336-43. 2008
  2. doi request reprint The changing epidemiology of Staphylococcus aureus bloodstream infection: a multinational population-based surveillance study
    K B Laupland
    Department of Medicine, University of Calgary, Calgary, AB, Canada
    Clin Microbiol Infect 19:465-71. 2013
  3. pmc Mortality associated with timing of admission to and discharge from ICU: a retrospective cohort study
    Kevin B Laupland
    University of Grenoble 1 Joseph Fourier Integrated Research Center U 823 Albert Bonniot Institute, Rond Point de la Chantourne 38706, La Tronche Cedex, France
    BMC Health Serv Res 11:321. 2011
  4. pmc Occurrence and adverse effect on outcome of hyperlactatemia in the critically ill
    Houman Khosravani
    Department of Critical Care Medicine, University of Calgary, Calgary, Alberta T2N 2T9, Canada
    Crit Care 13:R90. 2009
  5. pmc Kinetic bed therapy to prevent nosocomial pneumonia in mechanically ventilated patients: a systematic review and meta-analysis
    Anthony Delaney
    Intensive Care Unit, Royal North Shore Hospital, Sydney, NSW, Australia
    Crit Care 10:R70. 2006
  6. pmc Prognosis for long-term survival and renal recovery in critically ill patients with severe acute renal failure: a population-based study
    Sean M Bagshaw
    Department of Critical Care Medicine, Calgary Health Region, University of Calgary, Calgary, Alberta, Canada
    Crit Care 9:R700-9. 2005
  7. pmc SOFA is superior to MOD score for the determination of non-neurologic organ dysfunction in patients with severe traumatic brain injury: a cohort study
    David Zygun
    Department of Critical Care Medicine, University of Calgary, Alberta
    Crit Care 10:R115. 2006
  8. pmc Dialysis Disequilibrium Syndrome: brain death following hemodialysis for metabolic acidosis and acute renal failure--a case report
    Sean M Bagshaw
    Department of Critical Care Medicine, Calgary Health Region, University of Calgary, Calgary, Alberta, Canada
    BMC Nephrol 5:9. 2004
  9. pmc Development of a Health-Related Quality of Life Questionnaire (HRQL) for patients with Extremity Soft Tissue Infections (ESTI)
    Aric J Storck
    Department of Emergency Medicine, Calgary Health Region, Calgary, Alberta, Canada
    BMC Infect Dis 6:148. 2006
  10. pmc Acute hepatic failure and multi-system organ failure secondary to replacement of the liver with metastatic melanoma
    Gilaad G Kaplan
    Department of Medicine, University of Calgary and Calgary Health Region, Calgary, Alberta, Canada
    BMC Cancer 5:67. 2005

Detail Information

Publications105 found, 100 shown here

  1. doi request reprint Staphylococcus aureus bloodstream infections: risk factors, outcomes, and the influence of methicillin resistance in Calgary, Canada, 2000-2006
    Kevin B Laupland
    Department of Medicine, University of Calgary and Calgary Health Region, Calgary, Alberta, Canada
    J Infect Dis 198:336-43. 2008
    ..We sought to describe the epidemiological profile of S. aureus bacteremia and to assess whether the incidence and severity of and the antimicrobial resistance rates associated with this bacteremia are increasing...
  2. doi request reprint The changing epidemiology of Staphylococcus aureus bloodstream infection: a multinational population-based surveillance study
    K B Laupland
    Department of Medicine, University of Calgary, Calgary, AB, Canada
    Clin Microbiol Infect 19:465-71. 2013
    ..Although major changes in the epidemiology of community-onset and hospital-onset MSSA and MRSA BSIs are occurring, this multinational population-based study did not find that the overall incidence of S. aureus BSI is increasing...
  3. pmc Mortality associated with timing of admission to and discharge from ICU: a retrospective cohort study
    Kevin B Laupland
    University of Grenoble 1 Joseph Fourier Integrated Research Center U 823 Albert Bonniot Institute, Rond Point de la Chantourne 38706, La Tronche Cedex, France
    BMC Health Serv Res 11:321. 2011
    ..The objective of this study was to assess effect of timing of admission to and discharge from ICUs and subsequent risk for death...
  4. pmc Occurrence and adverse effect on outcome of hyperlactatemia in the critically ill
    Houman Khosravani
    Department of Critical Care Medicine, University of Calgary, Calgary, Alberta T2N 2T9, Canada
    Crit Care 13:R90. 2009
    ..We sought to determine the occurrence and relation of hyperlactatemia with ICU mortality in all patients admitted to four ICUs in a large regional critical care system...
  5. pmc Kinetic bed therapy to prevent nosocomial pneumonia in mechanically ventilated patients: a systematic review and meta-analysis
    Anthony Delaney
    Intensive Care Unit, Royal North Shore Hospital, Sydney, NSW, Australia
    Crit Care 10:R70. 2006
    ..The objective of this study was to investigate whether kinetic bed therapy reduces the incidence of nosocomial pneumonia and improves outcomes in critically ill mechanically ventilated patients...
  6. pmc Prognosis for long-term survival and renal recovery in critically ill patients with severe acute renal failure: a population-based study
    Sean M Bagshaw
    Department of Critical Care Medicine, Calgary Health Region, University of Calgary, Calgary, Alberta, Canada
    Crit Care 9:R700-9. 2005
    ..Severe acute renal failure (sARF) is associated with considerable morbidity, mortality and use of healthcare resources; however, its precise epidemiology and long-term outcomes have not been well described in a non-specified population...
  7. pmc SOFA is superior to MOD score for the determination of non-neurologic organ dysfunction in patients with severe traumatic brain injury: a cohort study
    David Zygun
    Department of Critical Care Medicine, University of Calgary, Alberta
    Crit Care 10:R115. 2006
    ..To compare the discriminative ability of the SOFA and MOD scoring systems with respect to hospital mortality and unfavorable neurologic outcome in patients with severe traumatic brain injury admitted to intensive care...
  8. pmc Dialysis Disequilibrium Syndrome: brain death following hemodialysis for metabolic acidosis and acute renal failure--a case report
    Sean M Bagshaw
    Department of Critical Care Medicine, Calgary Health Region, University of Calgary, Calgary, Alberta, Canada
    BMC Nephrol 5:9. 2004
    ..We describe a case of DDS-induced cerebral edema that resulted in irreversible brain injury and death following acute HD and review the relevant literature of the association of DDS and HD...
  9. pmc Development of a Health-Related Quality of Life Questionnaire (HRQL) for patients with Extremity Soft Tissue Infections (ESTI)
    Aric J Storck
    Department of Emergency Medicine, Calgary Health Region, Calgary, Alberta, Canada
    BMC Infect Dis 6:148. 2006
    ..The objective of this study was to develop a health-related quality of life questionnaire (HRQL) for patients with extremity soft tissue infections (ESTI) for future use in clinical trials...
  10. pmc Acute hepatic failure and multi-system organ failure secondary to replacement of the liver with metastatic melanoma
    Gilaad G Kaplan
    Department of Medicine, University of Calgary and Calgary Health Region, Calgary, Alberta, Canada
    BMC Cancer 5:67. 2005
    ..Metastatic malignant melanoma to the liver resulting in fulminant hepatic failure is a rare occurrence...
  11. pmc Burden of community-onset bloodstream infection: a population-based assessment
    K B Laupland
    Department of Medicine, University of Calgary, and Calgary Health Region, Alberta, Canada
    Epidemiol Infect 135:1037-42. 2007
    ..Four hundred and sixty patients died in hospital for a case-fatality rate of 13%. Community-onset BSI is common and has a major patient and societal impact. These data support further efforts to reduce the burden of community-onset BSI...
  12. ncbi request reprint Population-based laboratory surveillance for tribe Proteeae isolates in a large Canadian health region
    K B Laupland
    Department of Medicine, University of Calgary and Calgary Health Region, Alberta, Canada
    Clin Microbiol Infect 13:683-8. 2007
    ..The occurrence, demographical risk-factors and microbiology of Proteeae isolates varied according to the individual species...
  13. ncbi request reprint Vascular and parameningeal infections of the head and neck
    Kevin B Laupland
    Department of Medicine, University of Calgary, Room 1W 415, 9, 3535 Research Road NW, Calgary, Alberta, Canada T2L 2K8
    Infect Dis Clin North Am 21:577-90, viii. 2007
    ..They usually arise as complications of otogenic, oropharyngeal, or paranasal sinus infections, and management involves an aggressive combined medical-surgical approach...
  14. ncbi request reprint Distribution and determinants of critical illness among status Aboriginal Canadians. A population-based assessment
    Kevin B Laupland
    Department of Critical Care Medicine, Calgary Health Region, University of Calgary, Calgary, Alberta, Canada T2L 2K8
    J Crit Care 21:243-7. 2006
    ..The aim of the study is to determine the incidence, demographic risk factors, and outcomes of critical illness among all adult status Aboriginal Canadians (SACs) admitted to intensive care units (ICUs)...
  15. ncbi request reprint Acute group A streptococcal mastoiditis complicated by pneumocephaly in a previously healthy adult
    Kevin B Laupland
    Department of Medicine, Peter Lougheed Centre and University of Calgary, Alberta, Canada
    Scand J Infect Dis 38:719-21. 2006
    ..We report a previously healthy adult patient who had acute bacteraemic S. pyogenes mastoiditis complicated by intra-cranial air. This novel report adds pneumocephaly to the currently recognized list of complications of acute mastoiditis...
  16. pmc Population-based laboratory surveillance of Hafnia alvei isolates in a large Canadian health region
    Kevin B Laupland
    Department of Medicine, University of Calgary and Calgary Health Region, Calgary Alberta, Canada
    Ann Clin Microbiol Antimicrob 5:12. 2006
    ..Hospital-based series have characterized Hafnia alvei primarily as an infrequent agent of polymicrobial nosocomial infections in males with underlying illness...
  17. ncbi request reprint Cost of intensive care unit-acquired bloodstream infections
    K B Laupland
    Department of Critical Care Medicine, University of Calgary, Calgary Health Region, Calgary, Alberta, Canada
    J Hosp Infect 63:124-32. 2006
    ..These data support expenditures on infection prevention and control programmes and further research into reducing the impact of these infections...
  18. ncbi request reprint Long-term mortality outcome associated with prolonged admission to the ICU
    Kevin B Laupland
    Department of Critical Care Medicine, University of Calgary and Calgary Health Region, Calgary, AB, Canada
    Chest 129:954-9. 2006
    ..The objective of this study was to describe the occurrence and factors predictive of prolonged ICU stay at admission, and to define the long-term (>/= 1 year) mortality outcome...
  19. ncbi request reprint Isolation of Candida species from critically ill patients
    Kevin B Laupland
    Department of Critical Care Medicine, Calgary Health Region, University of Calgary, Calgary, Alberta, Canada T2N 2T5
    J Crit Care 22:250-1. 2007
  20. ncbi request reprint Community-onset urinary tract infections: a population-based assessment
    K B Laupland
    Calgary Laboratory Services, Centre for Anti microbial Resistance, University of Calgary and Calgary Health Region, Room 1W 415, 9, 3535 Research Road NW, T2L 2K8 Calgary, AB, Canada
    Infection 35:150-3. 2007
    ..We therefore conducted population-based laboratory surveillance in order to define the incidence, demographic risk factors, etiology, and antimicrobial susceptibilities of community onset UTI in a large Canadian region...
  21. ncbi request reprint Investigation of sources of potential bias in laboratory surveillance for anti-microbial resistance
    Kevin B Laupland
    Department of Medicine, University of Calgary and Calgary Health Region, Calgary, Alberta, Canada
    Clin Invest Med 30:E159-66. 2007
    ..Our objective was to evaluate the potential magnitude of bias in reporting of etiologic agents and their resistance rates associated with inclusion of multiple patient samples and non-random timing and location of sampling...
  22. ncbi request reprint Population-based laboratory surveillance for Serratia species isolates in a large Canadian health region
    K B Laupland
    Department of Medicine, University of Calgary and Calgary Health Region, Calgary, AB, Canada
    Eur J Clin Microbiol Infect Dis 27:89-95. 2008
    ..Serratia species isolation is most commonly of community onset and older patients and males are at increased risk. Despite reports of increasing resistance among Serratia species, the incidence in our region remains at a low stable rate...
  23. doi request reprint Long-term mortality associated with community-onset bloodstream infection
    K B Laupland
    Department of Medicine, University of Calgary and Alberta Health Services, Calgary, AB, Canada
    Infection 39:405-10. 2011
    ..The objective of this study was to define the early (≤28 days) and late (>28 days) mortality and assess determinants of late death following community-onset bloodstream infection...
  24. doi request reprint Epidemiology of Haemophilus influenzae bacteremia: a multi-national population-based assessment
    Kevin B Laupland
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    J Infect 62:142-8. 2011
    ..Haemophilus influenzae is an important cause of invasive infection but contemporary data in non-selected populations is limited...
  25. doi request reprint Admission to hospital with community-onset bloodstream infection during the 'after hours' is not associated with an increased risk for death
    Kevin B Laupland
    Department of Medicine, University of Calgary and Alberta Health Services, Calgary, Alberta, Canada
    Scand J Infect Dis 42:862-5. 2010
    ..99, 95% confidence interval 0.83-1.16; p = 0.88). Admission with community-onset bloodstream infection during the after hours is not associated with adverse outcome in this region...
  26. pmc Salmonella enterica bacteraemia: a multi-national population-based cohort study
    Kevin B Laupland
    Department of Medicine, University of Calgary and Calgary Laboratory Services, Calgary, Alberta, Canada
    BMC Infect Dis 10:95. 2010
    ..However, population-based data are limited. The objective of this study was to define the occurrence of S. enterica bacteremia in a large international population and to evaluate temporal and regional differences...
  27. pmc Hospital mortality among major trauma victims admitted on weekends and evenings: a cohort study
    Kevin B Laupland
    Department of Medicine, University of Calgary and Calgary Health Region, Calgary, Alberta, Canada
    J Trauma Manag Outcomes 3:8. 2009
    ..Clinical and outcome information was obtained from regional databases. Weekends were defined as anytime Saturday or Sunday, evenings as 18:00-22:59, and nights as 23:00-07:59...
  28. pmc Rationale for and protocol of a multi-national population-based bacteremia surveillance collaborative
    Kevin B Laupland
    Departments of Medicine and Pathology and Laboratory Medicine, University of Calgary and Calgary Laboratory Services, Calgary, Alberta, Canada
    BMC Res Notes 2:146. 2009
    ..CONCLUSION: Future studies from this collaborative should lead to a better understanding of the epidemiology of bloodstream infections...
  29. doi request reprint Long-term mortality outcome of victims of major trauma
    Kevin B Laupland
    Department of Medicine, University of Calgary and Calgary Health Region, Calgary, Alberta, Canada
    Injury 41:69-72. 2010
    ..Although trauma is associated with major acute morbidity and mortality, its long-term outcome is less well defined. We sought to define the rate of readmission to hospital and long-term mortality of victims of major trauma...
  30. doi request reprint Fever in the critically ill medical patient
    Kevin B Laupland
    Department of Critical Care Medicine, University of Calgary, Calgary, Alberta, Canada
    Crit Care Med 37:S273-8. 2009
    ..Clinical trials specifically comparing fever management strategies in neurologically intact critically ill medical patients are needed...
  31. doi request reprint Surveillance for antimicrobial resistant organisms: potential sources and magnitude of bias
    O R Rempel
    O Brien Centre for the Bachelor of Health Sciences Program, Health Sciences Centre, Faculty of Medicine, University of Calgary, Alberta, Canada
    Epidemiol Infect 137:1665-73. 2009
    ..There are a number of potential biases that should be considered in the methodological design and interpretation of antimicrobial-resistant organism surveillance...
  32. doi request reprint The changing burden of pediatric bloodstream infections in Calgary, Canada, 2000-2006
    Kevin B Laupland
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    Pediatr Infect Dis J 28:114-7. 2009
    ....
  33. doi request reprint Incidence, risk factors and outcomes of Escherichia coli bloodstream infections in a large Canadian region
    K B Laupland
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    Clin Microbiol Infect 14:1041-7. 2008
    ..coli bacteraemia and identifies groups at increased risk for acquiring and dying from these infections. The emergence of ciprofloxacin resistance and its adverse effect on patient outcome is a major concern...
  34. doi request reprint Community-onset extended-spectrum beta-lactamase (ESBL) producing Escherichia coli: importance of international travel
    Kevin B Laupland
    Department of Medicine, University of Calgary and Calgary Health Region, Calgary, Alberta, Canada
    J Infect 57:441-8. 2008
    ..Extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli have emerged as significant causes of community-onset disease. We sought to identify risk factors for acquiring community-onset ESBL-producing E. coli...
  35. doi request reprint Occurrence and outcome of fever in critically ill adults
    Kevin B Laupland
    Department of Medicine, University of Calgary and Calgary Health Region, Calgary, Alberta, Canada
    Crit Care Med 36:1531-5. 2008
    ..The objective of this study was to describe the occurrence of fever in the critically ill and assess its effect on ICU outcome...
  36. ncbi request reprint Population-based surveillance of invasive pyogenic streptococcal infection in a large Canadian region
    K B Laupland
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    Clin Microbiol Infect 12:224-30. 2006
    ..Differences in the seasonal occurrence and focus of infection occurred between the different groups...
  37. ncbi request reprint One-year mortality of bloodstream infection-associated sepsis and septic shock among patients presenting to a regional critical care system
    Kevin B Laupland
    Department of Critical Care Medicine, University of Calgary, 3535 Research Road NW, Calgary, AB, T2L 2K8, Canada
    Intensive Care Med 31:213-9. 2005
    ....
  38. ncbi request reprint Intravenous immunoglobulin for severe infections: a survey of Canadian specialists
    Kevin B Laupland
    Department of Critical Care Medicine, University of Calgary, and Calgary Health Region, Calgary, Alberta, Canada
    J Crit Care 19:75-81. 2004
    ..To survey the opinions of Canadian critical care medicine and infectious disease specialists about the use of intravenous immunoglobulin (IVIG) for the treatment of severe infections...
  39. ncbi request reprint Invasive Candida species infections: a 5 year population-based assessment
    Kevin B Laupland
    Department of Medicine, Calgary Health Region and University of Calgary, Calgary, Alberta, Canada
    J Antimicrob Chemother 56:532-7. 2005
    ..The objective of this study was to define the occurrence of, risk factors for, and antifungal susceptibilities of invasive Candida species infections in a large Canadian health region...
  40. ncbi request reprint Intensive-care-unit-acquired bloodstream infections in a regional critically ill population
    K B Laupland
    Department of Critical Care Medicine, University of Calgary and Calgary Health Region, Calgary, Alta, Canada
    J Hosp Infect 58:137-45. 2004
    ..0001) Development of an ICU-acquired BSI was an independent risk factor for death (OR 1.79; 95% CI 1.3-2.5) and increases the risk of dying from critical illness...
  41. pmc Population-based epidemiology of intensive care: critical importance of ascertainment of residency status
    Kevin B Laupland
    Department of Critical Care Medicine, University of Calgary, Calgary Health Region, and Calgary Laboratory Services, Calgary, Alberta, Canada
    Crit Care 8:R431-6. 2004
    ..The objective of this study was to evaluate the potential effects of inclusion of nonresidents in population-based studies in intensive care...
  42. pmc Intensive care unit-acquired urinary tract infections in a regional critical care system
    Kevin B Laupland
    Department of Critical Care Medicine, Center for Anti microbial Resistance, Calgary Health Region, Calgary Laboratory Services, and University of Calgary, Calgary, Alberta, Canada
    Crit Care 9:R60-5. 2005
    ..The objectives of this study were to describe the occurrence, microbiology, and risk factors for acquiring UTIs in the ICU and to determine whether these infections independently increase mortality...
  43. pmc Blood cultures in ambulatory outpatients
    Kevin B Laupland
    Department of Medicine, Centre for Anti microbial Resistance and Infectious Diseases Research Group, University of Calgary, Calgary Health Region, and Calgary Laboratory Services, Calgary, Alberta, Canada
    BMC Infect Dis 5:35. 2005
    ..However, the low yield may limit their usefulness, particularly in low-risk populations. This study was conducted to assess the utility of blood cultures drawn from ambulatory outpatients...
  44. ncbi request reprint Treatment of Staphylococcus aureus colonization and prophylaxis for infection with topical intranasal mupirocin: an evidence-based review
    Kevin B Laupland
    Department of Medicine, University of Calgary and the Calgary Health Region, Calgary, Alberta, Canada
    Clin Infect Dis 37:933-8. 2003
    ..Although mupirocin is effective at reducing nasal carriage, routine use of topical intranasal mupirocin for infection prophylaxis is not supported by the currently available evidence...
  45. ncbi request reprint To close or not to close, that is one of the questions? Perceptions of Trauma Association of Canada surgical members on the management of the open abdomen
    Shahzeer Karmali
    Foothills Medical Centre, Calgary, Alberta, Canada
    J Trauma 60:287-93. 2006
    ..We sought to evaluate clinical equipoise by surveying Canadian surgeons regarding the use of temporary abdominal closure strategies in damage control and emergency situations...
  46. doi request reprint Epidemiology of Clostridium species bacteremia in Calgary, Canada, 2000-2006
    J Leal
    Department of Medicine, University of Calgary, Calgary Health Region, Calgary, Alberta, Canada
    J Infect 57:198-203. 2008
    ..To define the incidence, risk factors for acquisition, and outcomes associated with clostridial bacteremia in a large Canadian health region...
  47. ncbi request reprint Bloodstream infection-associated sepsis and septic shock in critically ill adults: a population-based study
    K B Laupland
    Department of Critical Care Medicine, Foothills Medical Centre, 1403 29th Street NW, Calgary, Alberta, Canada T2N 2L9
    Infection 32:59-64. 2004
    ..The objective of this study was to define the epidemiology of bloodstream infection (BSI)-associated sepsis and septic shock among all critically ill patients in a large, fully integrated health region in Canada...
  48. doi request reprint Population-based study of the epidemiology and the risk factors for Pseudomonas aeruginosa bloodstream infection
    M D Parkins
    Dept of Medicine, Calgary Health Region, Alberta, Canada
    Infection 38:25-32. 2010
    ..We sought to describe the incidence rate, risk factors, and outcomes associated with P. aeruginosa bacteremia in a large Canadian health region...
  49. ncbi request reprint Severe bloodstream infections: a population-based assessment
    Kevin B Laupland
    Department of Critical Care Medicine, University of Calgary, Calgary Health Region, and Calgary Laboratory Services, Calgary, Alberta, Canada
    Crit Care Med 32:992-7. 2004
    ..We sought to define the incidence and microbiology of severe bloodstream infection (bloodstream infection associated with intensive care unit admission within 48 hrs) and assess risk factors for acquisition and death...
  50. doi request reprint Population-based assessment of the incidence, risk factors, and outcomes of anaerobic bloodstream infections
    J T Ngo
    Department of Medicine, Alberta Health Services, The University of Calgary, 3330 Hospital Drive NW, Calgary, AB, T2N 4N1, Canada
    Infection 41:41-8. 2013
    ..However, their epidemiology has not been well defined in non-selected populations. We sought to describe the incidence of, risk factors for, and outcomes associated with anaerobic bacteremia...
  51. ncbi request reprint Treatment of infections caused by metallo-beta-lactamase-producing Pseudomonas aeruginosa in the Calgary Health Region
    M D Parkins
    Department of Medicine, University of Calgary, Calgary Health Region, Calgary, Alberta, Canada
    Clin Microbiol Infect 13:199-202. 2007
    ..45). Further prospective studies are warranted to determine the optimal treatment of MBL-producing P. aeruginosa infections...
  52. ncbi request reprint Are occult pneumothoraces truly occult or simply missed?
    Chad G Ball
    Department of Surgery, Foothills Medical Centre, Calgary, Alberta, Canada
    J Trauma 60:294-8 discussion 298-9. 2006
    ..The purpose was to (1) determine whether perceived OPTXs were truly occult or simply missed and (2) address factors that contribute to the poor sensitivity of the supine CXR...
  53. doi request reprint Population-based laboratory assessment of the burden of community-onset bloodstream infection in Victoria, Canada
    K B Laupland
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    Epidemiol Infect 141:174-80. 2013
    ..The in-hospital case-fatality rate was 13%. Community-onset BSI is associated with a major burden of illness. These data support ongoing and future preventative and research efforts aimed at reducing the major impact of these infections...
  54. doi request reprint Cost and outcomes of nosocomial bloodstream infections complicating major traumatic injury
    D J Niven
    Department of Critical Care Medicine, University of Calgary, Calgary, Alberta, Canada
    J Hosp Infect 76:296-9. 2010
    ..Our data provide justification to support efforts to reduce the adverse impact of BSI in trauma victims...
  55. ncbi request reprint Population-based assessment of intensive care unit-acquired bloodstream infections in adults: Incidence, risk factors, and associated mortality rate
    Kevin B Laupland
    Division of Critical Care Medicine, University of Calgary, Calgary Health Region, Alberta, Canada
    Crit Care Med 30:2462-7. 2002
    ..The study objective was to define the incidence, risk factors, microbiology, and clinical outcomes of intensive care unit-acquired bloodstream infections...
  56. ncbi request reprint Population-based laboratory surveillance for Escherichia coli-producing extended-spectrum beta-lactamases: importance of community isolates with blaCTX-M genes
    Johann D D Pitout
    Department of Pathology and Laboratory Medicine, University of Calgary, Calgary Laboratory Services, and the Centre for Antimicrobial Resistance, Calgary, Alberta, Canada
    Clin Infect Dis 38:1736-41. 2004
    ..2; 95% confidence interval, 3.69-54.84). Strains of E. coli with blaCTX-M genes commonly cause community-onset infections, and women and older patients are at highest risk...
  57. pmc Population-based laboratory surveillance for AmpC beta-lactamase-producing Escherichia coli, Calgary
    Johann D D Pitout
    University of Calgary, Calgary, Alberta, Canada
    Emerg Infect Dis 13:443-8. 2007
    ..In this large Canadian region, AmpC beta-lactamase-producing E. coli is an emerging community pathogen that commonly causes urinary tract infections in older women...
  58. ncbi request reprint Population-based study of the epidemiology of and the risk factors for invasive Staphylococcus aureus infections
    Kevin B Laupland
    Department of Medicine, University of Calgary, Calgary Health Region, Calgary, Canada
    J Infect Dis 187:1452-9. 2003
    ..This study provides important data on the burden of ISA disease and identifies risk groups that may potentially benefit from preventive efforts...
  59. ncbi request reprint Adequacy of empirical antifungal therapy and effect on outcome among patients with invasive Candida species infections
    Michael D Parkins
    Department of Medicine, Calgary Health Region and University of Calgary, Calgary, Alberta, Canada
    J Antimicrob Chemother 60:613-8. 2007
    ..We sought to assess the adequacy of empirical therapy and its effect on mortality in invasive Candida species infections...
  60. doi request reprint Concomitant ceftriaxone and high-concentration intravenous calcium therapy in adult critical care patients: a matched cohort study
    Bruce R Dalton
    Department of Pharmacy Services, Foothills Medical Centre, Alberta Health Services, Calgary, Alberta, Canada
    Ann Pharmacother 44:1158-63. 2010
    ..Systematic population-based data to guide clinicians with respect to this risk are, however, lacking...
  61. ncbi request reprint Incidence and risk factors for acquiring nosocomial urinary tract infection in the critically ill
    Kevin B Laupland
    Division of Critical Care Medicine, University of Calgary, Calgary Health Region, Canada
    J Crit Care 17:50-7. 2002
    ..However, the epidemiology of intensive care unit (ICU)-acquired UTIs is not well defined. The objective of this study was to describe the incidence, risk factors, and clinical outcomes of ICU-acquired UTIs...
  62. pmc Community-wide outbreaks of clonally related CTX-M-14 beta-lactamase-producing Escherichia coli strains in the Calgary health region
    Johann D D Pitout
    Division of Microbiology, Calgary Laboratory Services, 9 3535 Research Rd NW, Calgary, Alberta T2L 2K8, Canada
    J Clin Microbiol 43:2844-9. 2005
    ..Further studies are warranted to investigate whether community-onset diseases caused by ESBL-producing E. coli are related to a point source or transmission within the community...
  63. ncbi request reprint Severe traumatic brain injury in a large Canadian health region
    David A Zygun
    Department of Critical Care Medicine, University of Calgary and the Calgary Health Region, Calgary, AB Canada
    Can J Neurol Sci 32:87-92. 2005
    ..We sought to define the incidence, risk factors and outcome of patients suffering sTBI in a large Canadian region...
  64. ncbi request reprint Olecranon septic bursitis managed in an ambulatory setting. The Calgary Home Parenteral Therapy Program Study Group
    K B Laupland
    Department of Microbiology and Infectious Diseases, University of Calgary, Alta
    Clin Invest Med 24:171-8. 2001
    ..CONCLUSION: OSB is more common than reported and can be treated successfully in ambulatory settings with sequential intravenous therapy followed by oral therapy and drainage in selected cases...
  65. ncbi request reprint Renal recovery after severe acute renal failure
    S M Bagshaw
    Department of Critical Care Medicine, Calgary Health Region and University of Calgary, Calgary, Alberta, Canada
    Int J Artif Organs 29:1023-30. 2006
    ..There is limited information about renal recovery to independence from renal replacement therapy (RRT) and about factors associated with its occurrence after severe acute renal failure (ARF)...
  66. ncbi request reprint Evaluation of a rapid bacterial ATP assay for screening BAL samples from ICU patients submitted for quantitative bacterial cultures
    Kevin B Laupland
    Department of Critical Care Medicine, University of Calgary and Calgary Laboratory Services, Calgary, Alberta, Canada
    Diagn Microbiol Infect Dis 47:465-9. 2003
    ..A combined negative rapid test consisting of Gram's stain/bacterial ATP assay rules out significant bacteria in BAL samples with a high degree of certainty. Future studies are needed to clinically validate these observations...
  67. ncbi request reprint Non-neurologic organ dysfunction in severe traumatic brain injury
    David A Zygun
    Departments of Critical Care Medicine, University of Calgary, Calgary Alberta, Canada
    Crit Care Med 33:654-60. 2005
    ..To describe the incidence of non-neurologic organ dysfunction and its association with outcome in patients with severe traumatic brain injury admitted to intensive care...
  68. ncbi request reprint Outpatient parenteral antibiotic therapy: evolution of the Calgary adult home parenteral therapy program
    Kevin B Laupland
    Department of Medicine, University of Calgary, Alta
    Clin Invest Med 25:185-90. 2002
    ....
  69. ncbi request reprint Polyclonal intravenous immunoglobulin for the treatment of severe sepsis and septic shock in critically ill adults: a systematic review and meta-analysis
    Kevin B Laupland
    Department of Critical Care Medicine, University of Calgary, Calgary, AB, Canada
    Crit Care Med 35:2686-92. 2007
    ..To systematically review the literature to assess whether adjunctive therapy with polyclonal intravenous immunoglobulin (ivIg) reduces mortality among critically ill adults with severe sepsis and septic shock...
  70. ncbi request reprint Incidence, risk factors, and outcomes for occult pneumothoraces in victims of major trauma
    Chad G Ball
    Department of Surgery, Foothills Medical Centre, Calgary, Alberta, Canada
    J Trauma 59:917-24; discussion 924-5. 2005
    ..Computed tomographic (CT) scanning often detects PTXs that were not diagnosed on CXR (occult PTXs [OPTXs]). The purpose of this study was to define the incidence, predictors, and outcomes for OPTXs after trauma...
  71. doi request reprint Defining the epidemiology of bloodstream infections: the 'gold standard' of population-based assessment
    K B Laupland
    Departments of Medicine, Critical Care Medicine, Community Health Sciences, and Pathology and Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada
    Epidemiol Infect 141:2149-57. 2013
    ..Due to their comprehensive nature and intrinsic minimization of bias, population-based designs should be considered the gold standard means of defining the epidemiology of an infectious disease...
  72. pmc Molecular characteristics of extended-spectrum-beta-lactamase-producing Escherichia coli isolates causing bacteremia in the Calgary Health Region from 2000 to 2007: emergence of clone ST131 as a cause of community-acquired infections
    Johann D D Pitout
    Division of Microbiology, Calgary Laboratory Services, 9, 3535 Research Road NW, Calgary, Alberta, Canada
    Antimicrob Agents Chemother 53:2846-51. 2009
    ..coli isolates; and this is the first study to identify CTX-M-14 in E. coli clone ST131...
  73. ncbi request reprint A population-based assessment of major trauma in a large Canadian region
    Kevin B Laupland
    Department of Critical Care Medicine, University of Calgary and the Calgary Health Region, Calgary, Alberta, Canada
    Am J Surg 189:571-5; discussion 576. 2005
    ..The cause of major trauma has not been well defined using population-based methodologies...
  74. ncbi request reprint Clostridium perfringens pleuropulmonary infection and septic shock: case report and population-based laboratory surveillance study
    Shannon Jackson
    Department of Medicine, Calgary Laboratory Services, University of Calgary, and the Calgary Health Region, Calgary, Alberta, Canada
    Scand J Infect Dis 35:883-6. 2003
    ..Population-based laboratory surveillance was subsequently conducted that identified an annual incidence of invasive C. perfringens disease of 0.83 per 100,000 population with a striking age-related increased risk for acquisition...
  75. doi request reprint A population-based study of pyogenic liver abscesses in the United States: incidence, mortality, and temporal trends
    Liisa Meddings
    Department of Medicine, University of Calgary, Alberta, Canada
    Am J Gastroenterol 105:117-24. 2010
    ..Few population-based studies have evaluated pyogenic liver abscess (PLA) in North America. We assessed the incidence of PLA and evaluated predictors of mortality...
  76. ncbi request reprint Spill your guts! Perceptions of Trauma Association of Canada member surgeons regarding the open abdomen and the abdominal compartment syndrome
    Andrew W Kirkpatrick
    Department of Medicine, Foothills Medical Centre, Calgary, Alberta, Canada
    J Trauma 60:279-86. 2006
    ..To survey surgeon opinion regarding the management of the open abdomen (OA) and abdominal compartment syndrome (ACS) to assess current practice and direct future prospective clinical studies...
  77. doi request reprint Hospital mortality among adults admitted to and discharged from intensive care on weekends and evenings
    Kevin B Laupland
    Department of Critical Care Medicine, University of Calgary and Calgary Health Region, Calgary, Alberta, Canada
    J Crit Care 23:317-24. 2008
    ..Patient care may be inconsistent during off hours. We sought to determine whether adults admitted to or discharged from intensive care units (ICUs) on evenings and weekends have increased mortality rates...
  78. doi request reprint Antimicrobial susceptibility of well-characterised multiresistant CTX-M-producing Escherichia coli: failure of automated systems to detect resistance to piperacillin/tazobactam
    Johann D D Pitout
    Division of Microbiology, Calgary Laboratory Services, Calgary, Alberta, Canada
    Int J Antimicrob Agents 32:333-8. 2008
    ..coli. We recommend that laboratories using Vitek should employ alternative susceptibility testing methods for TZP before reporting the activity of this agent against ESBL-producing E. coli...
  79. ncbi request reprint Ventilator-associated pneumonia in severe traumatic brain injury
    David A Zygun
    Department of Critical Care Medicine, University of Calgary, Calgary, Alberta, Canada
    Neurocrit Care 5:108-14. 2006
    ..An additional goal was to define the relationship of ventilator-associated pneumonia (VAP) with nonneurological organ dysfunction...
  80. doi request reprint Time to blood culture positivity in Staphylococcus aureus bacteremia: association with 30-day mortality
    Joseph Kim
    Division of Infectious Diseases, University of Calgary, 3500 26 Avenue NE, Calgary, AB, Canada T1Y 6J4
    J Infect 61:197-204. 2010
    ..This study describes the relationship between TTP and clinical outcome in all patients with Staphylococcus aureus bacteremia (SAB) in a large Canadian health region...
  81. pmc Molecular epidemiology of CTX-M-producing Escherichia coli in the Calgary Health Region: emergence of CTX-M-15-producing isolates
    Johann D D Pitout
    Calgary Laboratory Services, Department of Pathology and Laboratory Medicine, University of Calgary, 9, 3535 Research Road NW, Calgary, Alberta, Canada T2L 2K8
    Antimicrob Agents Chemother 51:1281-6. 2007
    ..This study illustrates the importance of molecular surveillance in tracking CTX-M-producing E. coli strains in the community and investigating their influx into hospitals...
  82. pmc Prospective evaluation of hand-held focused abdominal sonography for trauma (FAST) in blunt abdominal trauma
    Andrew W Kirkpatrick
    Department of Critical Care Medicine, Foothills Medical Centre, Calgary, Alberta
    Can J Surg 48:453-60. 2005
    ..Although hand-held US equipment is now commercially available and may expand the availability and speed of US in assessing the trauma patient, it has not been subjected to controlled evaluation in early trauma care...
  83. ncbi request reprint The hand-held ultrasound examination for penetrating abdominal trauma
    Andrew W Kirkpatrick
    Department of Critical Care Medicine, Foothills Medical Center, Calgary, Alberta, Canada
    Am J Surg 187:660-5. 2004
    ..An evaluation of hand-held ultrasonography (US) in the assessment of penetrating torso trauma has not yet been reported...
  84. doi request reprint Incidence of bloodstream infection: a review of population-based studies
    K B Laupland
    Departments of Medicine, Critical Care Medicine, Community Health Sciences, and Pathology and Laboratory Medicine, University of Calgary, Calgary, AB, Canada
    Clin Microbiol Infect 19:492-500. 2013
    ..Knowledge of the incidence of BSI is important for setting healthcare and research priorities and for evaluating the effectiveness of preventative interventions...
  85. ncbi request reprint "The higher the abdominal pressure, the less the secretion of urine": another target disease for renal ultrasonography?
    Andrew W Kirkpatrick
    Department of Surgery, Foothills Medical Centre, Calgary, Canada
    Crit Care Med 35:S206-7. 2007
  86. ncbi request reprint Hand-held thoracic sonography for detecting post-traumatic pneumothoraces: the Extended Focused Assessment with Sonography for Trauma (EFAST)
    A W Kirkpatrick
    Department of Critical Care Medicine, Foothills Medical Centre, Calgary, Alberta, Canada
    J Trauma 57:288-95. 2004
    ..However, the diagnostic utility of hand-held US has not been previously evaluated in this role...
  87. pmc Molecular characteristics of travel-related extended-spectrum-beta-lactamase-producing Escherichia coli isolates from the Calgary Health Region
    Johann D D Pitout
    Division of Microbiology, Calgary Laboratory Services, University of Calgary, Calgary, Alberta, Canada
    Antimicrob Agents Chemother 53:2539-43. 2009
    ..Our study suggested that clone ST131 coproducing CTX-M-15, OXA-1, TEM-1, and AAC(6')-Ib-cr and clonally unrelated CTX-M-14 producers have emerged as important causes of community-acquired, travel-related infections...
  88. doi request reprint Extended-spectrum beta-lactamase-producing Enterobacteriaceae: an emerging public-health concern
    Johann D D Pitout
    Division of Microbiology, Calgary Laboratory Services, Department of Microbiology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada
    Lancet Infect Dis 8:159-66. 2008
    ..Thus, more rapid diagnostic testing of ESBL-producing bacteria and the possible modification of guidelines for community-onset bacteraemia associated with UTIs are required...
  89. ncbi request reprint Population-based epidemiological study of infections caused by carbapenem-resistant Pseudomonas aeruginosa in the Calgary Health Region: importance of metallo-beta-lactamase (MBL)-producing strains
    Kevin B Laupland
    Department of Medicine, University of Calgary, Centre for Anti microbial Resistance, and Calgary Health Region, Calgary, Alberta, Canada
    J Infect Dis 192:1606-12. 2005
    ....
  90. ncbi request reprint Epidemiology of intensive care unit-acquired urinary tract infections
    Sean M Bagshaw
    Department of Critical Care Medicine, Calgary Laboratory Services, Calgary Health Region, and University of Calgary, Calgary, Alberta, Canada
    Curr Opin Infect Dis 19:67-71. 2006
    ..We review the occurrence, microbiology, risk factors for acquisition, and outcomes associated with intensive care unit-acquired urinary tract infections...
  91. doi request reprint Epidemiology of Staphylococcus aureus nasal colonization and influence on outcome in the critically ill
    Daniel J Niven
    Department of Medicine, University of Calgary, Calgary Health Region, and Calgary Laboratory Services, Calgary, Alberta, Canada
    J Crit Care 24:583-9. 2009
    ..To determine the rate of Staphylococcus aureus nasal colonization at admission to intensive care units (ICU) and assess its effect on the development of an ICU-acquired S aureus infection...
  92. doi request reprint Incidence, risk factors, and outcomes of Klebsiella pneumoniae bacteremia
    Bonnie L Meatherall
    Department of Medicine, University of Calgary and Calgary Laboratory Services, Calgary, Alberta, Canada
    Am J Med 122:866-73. 2009
    ..We sought to describe the incidence of, risk factors for, and outcomes associated with K. pneumoniae bacteremia...
  93. doi request reprint Validity of ascertainment of co-morbid illness using administrative databases: a systematic review
    J R Leal
    Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada
    Clin Microbiol Infect 16:715-21. 2010
    ..Studies evaluating administrative database ascertainment of co-morbidities specifically in infectious diseases research are needed...
  94. doi request reprint Validity of electronic surveillance systems: a systematic review
    J Leal
    Department of Community Health Sciences, University of Calgary, Calgary Health Region, Calgary, Alberta, Canada
    J Hosp Infect 69:220-9. 2008
    ..Electronic surveillance has moderate to excellent utility compared with conventional methods for nosocomial infections. Future studies are needed to refine electronic algorithms further, especially with community-onset infections...
  95. ncbi request reprint Renal arterial resistive index response to intraabdominal hypertension in a porcine model
    Andrew W Kirkpatrick
    Department of Surgery, Foothills Medical Centre, Calgary, Alberta, Canada
    Crit Care Med 35:207-13. 2007
    ....
  96. ncbi request reprint Characteristics and conviction rates of injured alcohol-impaired drivers admitted to a tertiary care Canadian Trauma Centre
    Michelle E Goecke
    Departments of Surgery, University of Calgary, Calgary, Alberta, Canada
    Clin Invest Med 30:26-32. 2007
    ..Despite greater societal attention, medical admission after MVC results in avoidance of legal consequences. We sought to determine characteristics of, and consequences to, injured alcohol-impaired drivers (IAIDs)...
  97. ncbi request reprint Validation of a rapid diagnostic strategy for determination of significant bacterial counts in bronchoalveolar lavage samples
    Kevin B Laupland
    Department of Critical Care Medicine, Centre for Antimicrobial Resistance, University of Calgary, Alberta, Canada
    Arch Pathol Lab Med 129:78-81. 2005
    ..We developed a rapid diagnostic testing strategy that is highly sensitive for screening bacteria in bronchoalveolar lavage (BAL) samples, with results available within hours of collection...
  98. ncbi request reprint The burden of large and small duct primary sclerosing cholangitis in adults and children: a population-based analysis
    Gilaad G Kaplan
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    Am J Gastroenterol 102:1042-9. 2007
    ....
  99. ncbi request reprint Factors related to the failure of radiographic recognition of occult posttraumatic pneumothoraces
    Chad G Ball
    Department of Surgery, Foothills Medical Centre, Room EG23, 1403 29 Street NW, Calgary, Alberta, Canada
    Am J Surg 189:541-6; discussion 546. 2005
    ..Computed tomography (CT) often identifies occult pneumothoraces (OPTXs). Previous descriptions of OPTX topography have been poor. Our purpose was to define their distribution and aid in the targeting of thoracic ultrasound...
  100. doi request reprint Validation and experience with a simple continuous intra-abdominal pressure measurement technique in a multidisciplinary medical/surgical critical care unit
    Imme Zengerink
    Department of Medicine, Maastricht University, The Netherlands
    J Trauma 64:1159-64. 2008
    ..We evaluated a new technique for continuous monitoring of intra-abdominal pressure (CIAP) using a standard three-way bladder catheter in a diverse group of intensive care unit patients...
  101. ncbi request reprint Population-based study of the epidemiology of and the risk factors for pyogenic liver abscess
    Gilaad G Kaplan
    Department of Medicine, University of Calgary, Calgary Health Region, Alberta, Canada
    Clin Gastroenterol Hepatol 2:1032-8. 2004
    ..Our objective was to characterize the incidence of, risk factors for, and outcomes of PLA in a nonselected population...