Matthew B Lanktree

Summary

Affiliation: University of Western Ontario
Country: Canada

Publications

  1. doi request reprint Genetic variation in hyaluronan metabolism loci is associated with plasma plasminogen activator inhibitor-1 concentration
    Matthew B Lanktree
    Department of Medicine, Robarts Research Institute and Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada
    Blood 116:2160-3. 2010
  2. pmc An increased burden of common and rare lipid-associated risk alleles contributes to the phenotypic spectrum of hypertriglyceridemia
    Christopher T Johansen
    Department of Biochemistry, Robarts Research Institute, University of Western Ontario, London, Canada
    Arterioscler Thromb Vasc Biol 31:1916-26. 2011
  3. doi request reprint Comprehensive analysis of genomic variation in the LPA locus and its relationship to plasma lipoprotein(a) in South Asians, Chinese, and European Caucasians
    Matthew B Lanktree
    Department of Medicine and Biochemistry, Robarts Research Institute and Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    Circ Cardiovasc Genet 3:39-46. 2010
  4. pmc Excess of rare variants in non-genome-wide association study candidate genes in patients with hypertriglyceridemia
    Christopher T Johansen
    Department of Biochemistry, Robarts Research Institute, University of Western Ontario, London, ON, Canada
    Circ Cardiovasc Genet 5:66-72. 2012
  5. doi request reprint Advances in genomic analysis of stroke: what have we learned and where are we headed?
    Matthew B Lanktree
    Robarts Research Institute and Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    Stroke 41:825-32. 2010
  6. doi request reprint Multi-ethnic genetic association study of carotid intima-media thickness using a targeted cardiovascular SNP microarray
    Matthew B Lanktree
    Robarts Research Institute and Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    Stroke 40:3173-9. 2009
  7. pmc BRCA2 variants and cardiovascular disease in a multi-ethnic study
    Kevin Zbuk
    Population Health Research Institute, Hamilton Health Sciences, Hamilton, ON, Canada
    BMC Med Genet 13:56. 2012
  8. pmc Replication of genetic associations with plasma lipoprotein traits in a multiethnic sample
    Matthew B Lanktree
    Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    J Lipid Res 50:1487-96. 2009
  9. pmc Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia
    Christopher T Johansen
    Department of Biochemistry, University of Western Ontario, London, Ontario, Canada
    Nat Genet 42:684-7. 2010
  10. pmc Determination of lipoprotein(a) kringle repeat number from genomic DNA: copy number variation genotyping using qPCR
    Matthew B Lanktree
    Robarts Research Institute, Departments of Medicine and Biochemistry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    J Lipid Res 50:768-72. 2009

Detail Information

Publications16

  1. doi request reprint Genetic variation in hyaluronan metabolism loci is associated with plasma plasminogen activator inhibitor-1 concentration
    Matthew B Lanktree
    Department of Medicine, Robarts Research Institute and Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada
    Blood 116:2160-3. 2010
    ..The protein products of 2 of these loci, hyaluronan binding protein 2 (HABP2) and hyaluronoglucosaminidase 1 (HYAL1), play key roles in hyaluronan metabolism, providing genetic evidence to link these pathways...
  2. pmc An increased burden of common and rare lipid-associated risk alleles contributes to the phenotypic spectrum of hypertriglyceridemia
    Christopher T Johansen
    Department of Biochemistry, Robarts Research Institute, University of Western Ontario, London, Canada
    Arterioscler Thromb Vasc Biol 31:1916-26. 2011
    ..Here, we comprehensively analyzed 504 HLP-HTG patients and 1213 normotriglyceridemic controls and confirmed that a spectrum of common and rare lipid-associated variants underlies this heterogeneity...
  3. doi request reprint Comprehensive analysis of genomic variation in the LPA locus and its relationship to plasma lipoprotein(a) in South Asians, Chinese, and European Caucasians
    Matthew B Lanktree
    Department of Medicine and Biochemistry, Robarts Research Institute and Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    Circ Cardiovasc Genet 3:39-46. 2010
    ..Genomic analysis of LPA, including both single-nucleotide polymorphisms (SNPs) and kringle IV type 2 (KIV-2) copy number, has yet to be performed...
  4. pmc Excess of rare variants in non-genome-wide association study candidate genes in patients with hypertriglyceridemia
    Christopher T Johansen
    Department of Biochemistry, Robarts Research Institute, University of Western Ontario, London, ON, Canada
    Circ Cardiovasc Genet 5:66-72. 2012
    ..We sought to determine whether rare variants in non-GWAS candidate genes identified from mouse models and human mendelian syndromes of hypertriglyceridemia (HTG) accumulate in patients with polygenic adult-onset HTG...
  5. doi request reprint Advances in genomic analysis of stroke: what have we learned and where are we headed?
    Matthew B Lanktree
    Robarts Research Institute and Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    Stroke 41:825-32. 2010
    ..Intelligent, appropriately powered, multidisciplinary studies incorporating knowledge from clinical medicine, epidemiology, genetics, and molecular biology will be required to fully characterize the genomic contributors to stroke...
  6. doi request reprint Multi-ethnic genetic association study of carotid intima-media thickness using a targeted cardiovascular SNP microarray
    Matthew B Lanktree
    Robarts Research Institute and Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    Stroke 40:3173-9. 2009
    ....
  7. pmc BRCA2 variants and cardiovascular disease in a multi-ethnic study
    Kevin Zbuk
    Population Health Research Institute, Hamilton Health Sciences, Hamilton, ON, Canada
    BMC Med Genet 13:56. 2012
    ..We therefore tested the association of BRCA2 variants with clinical cardiovascular disease (CVD)...
  8. pmc Replication of genetic associations with plasma lipoprotein traits in a multiethnic sample
    Matthew B Lanktree
    Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    J Lipid Res 50:1487-96. 2009
    ..The findings indicate the potential utility of the Illumina CVD beadchip, but they underscore the need to consider meta-analysis of results from commonly studied clinical or epidemiological samples...
  9. pmc Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia
    Christopher T Johansen
    Department of Biochemistry, University of Western Ontario, London, Ontario, Canada
    Nat Genet 42:684-7. 2010
    ..1% of affected individuals and 15.3% of controls (P = 2.6 x 10(-5)). Considering rare variants in these genes incrementally increased the proportion of genetic variation contributing to HTG...
  10. pmc Determination of lipoprotein(a) kringle repeat number from genomic DNA: copy number variation genotyping using qPCR
    Matthew B Lanktree
    Robarts Research Institute, Departments of Medicine and Biochemistry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    J Lipid Res 50:768-72. 2009
    ....
  11. pmc Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height
    Matthew B Lanktree
    Department of Medicine and Biochemistry, University of Western Ontario, London, Ontario, N6A 5C1, Canada
    Am J Hum Genet 88:6-18. 2011
    ..Overall, we show that dense coverage of genes for uncommon SNPs, coupled with large-scale meta-analysis, can successfully identify additional variants associated with a common complex trait...
  12. doi request reprint Translating genomic analyses into improved management of coronary artery disease
    Christopher T Johansen
    Blackburn Cardiovascular Genetics Laboratory, Robarts Research Institute, University of Western Ontario, London, ON N6A 5K8, Canada
    Future Cardiol 6:507-21. 2010
    ..This article outlines the relevance of genetic variation in the elucidation of novel CAD risk factors and the clinical utility of genetic variants in the management and treatment of CAD...
  13. doi request reprint A translational view of the genetics of lipodystrophy and ectopic fat deposition
    Matthew B Lanktree
    Departments of Medicine and Biochemistry, Schulich School of Medicine and Dentistry, Robarts Research Institute, University of Western Ontario, London, Ontario, Canada Blackburn Cardiovascular Genetics Laboratory, Robarts Research Institute, University of Western Ontario, London, Canada
    Prog Mol Biol Transl Sci 94:159-96. 2010
    ....
  14. doi request reprint Genetic risk factors for stroke in the genome-wide association era
    Neeraj Patel
    University of Western Ontario, Robarts Research Institute, Schulich School of Medicine and Dentistry, Blackburn Cardiovascular Genetics Laboratory, London, Ontario, Canada N6A 5K8 519 931 5271 519 931 5218
    Expert Opin Med Diagn 5:75-84. 2011
    ....
  15. doi request reprint Phenomics: expanding the role of clinical evaluation in genomic studies
    Matthew B Lanktree
    Department of Medicine, University of Western Ontario, London, Ontario, Canada
    J Investig Med 58:700-6. 2010
    ....
  16. pmc Gene-gene and gene-environment interactions: new insights into the prevention, detection and management of coronary artery disease
    Matthew B Lanktree
    Departments of Medicine and Biochemistry, Blackburn Cardiovascular Genetics Laboratory, Robarts Research Institute, University of Western Ontario, London, Ontario N6A 5K8, Canada
    Genome Med 1:28. 2009
    ..Here we discuss these issues, particularly in relation to the investigation and potential clinical utility of gene-gene and gene-environment interactions in CAD...