Research Topics
| R A LaniusSummaryAffiliation: University of Western Ontario Country: Canada Publications
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Detail Information
Publications
Neural correlates of traumatic memories in posttraumatic stress disorder: a functional MRI investigationR A Lanius
Department of Psychiatry, University of Western Ontario, London, Canada
Am J Psychiatry 158:1920-2. 2001..The neuronal circuitry underlying posttraumatic stress disorder (PTSD) was studied in traumatized subjects with and without PTSD...
How understanding the neurobiology of complex post-traumatic stress disorder can inform clinical practice: a social cognitive and affective neuroscience approachR A Lanius
Department of Psychiatry, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, ON, Canada
Acta Psychiatr Scand 124:331-48. 2011....
Does neuroimaging research examining the pathophysiology of posttraumatic stress disorder require medication-free patients?Ruth A Lanius
Department of Psychiatry, University of Western Ontario, London, Ont, Canada
J Psychiatry Neurosci 35:80-9. 2010..The evidence for potentially confounding effects of psychotherapy in PTSD are also discussed...
Default mode network connectivity as a predictor of post-traumatic stress disorder symptom severity in acutely traumatized subjectsR A Lanius
Department of Psychiatry, The University of Western Ontario, London, ON, Canada
Acta Psychiatr Scand 121:33-40. 2010..The goal of this study was to investigate the relationship between default mode network connectivity and the severity of post-traumatic stress disorder (PTSD) symptoms in a sample of eleven acutely traumatized subjects...
Neural correlates of trauma script-imagery in posttraumatic stress disorder with and without comorbid major depression: a functional MRI investigationRuth A Lanius
Department of Psychiatry, University of Western Ontario, London, Ontario, Canada
Psychiatry Res 155:45-56. 2007..These results suggest different patterns of brain activation related to comorbid major depression occurring in the context of PTSD...
A review of neuroimaging studies in PTSD: heterogeneity of response to symptom provocationR A Lanius
Department of Psychiatry, London Health Sciences Centre, University of Western Ontario, 339 Windermere Road, P O Box 5339, London, Ont, Canada N6A 5A5
J Psychiatr Res 40:709-29. 2006..This review will integrate findings of different experiential, psychophysiological, and neurobiological responses to traumatic symptom provocation with the clinical symptomatology and the neurobiology of PTSD...
Functional connectivity of dissociative responses in posttraumatic stress disorder: a functional magnetic resonance imaging investigationRuth A Lanius
Department of Psychiatry, University of Western Ontario, London, Ontario, Canada
Biol Psychiatry 57:873-84. 2005..The purpose of this study was to assess interregional brain activity covariations during traumatic script-driven imagery in subjects with posttraumatic stress disorder (PTSD)...
The nature of traumatic memories: a 4-T FMRI functional connectivity analysisRuth A Lanius
Department of Psychiatry, University of Western Ontario, London, Canada
Am J Psychiatry 161:36-44. 2004..This study used functional connectivity analyses to assess interregional brain activity correlations during the recall of traumatic memories in traumatized subjects with and without posttraumatic stress disorder (PTSD)...
Individual differences in a husband and wife who developed PTSD after a motor vehicle accident: a functional MRI case studyRuth A Lanius
Department of Psychiatry, Medical Biophysics, University of Western Ontario, London, Canada
Am J Psychiatry 160:667-9. 2003
Brain activation during script-driven imagery induced dissociative responses in PTSD: a functional magnetic resonance imaging investigationRuth A Lanius
Department of Psychiatry, University of Western Ontario, London, Ontario, Canada
Biol Psychiatry 52:305-11. 2002....
Alexithymia in PTSD: psychometric and FMRI studiesPaul A Frewen
London Health Sciences Centre, 339 Windermere Road, PO Box 5339, London, Ontario, Canada, N6A 5A5
Ann N Y Acad Sci 1071:397-400. 2006..In 26 individuals with PTSD, TAS-20 scores correlated positively with response in insula, posterior cingulate cortex (PCC), and thalamus, and negatively with response in ACC...
Switching between executive and default mode networks in posttraumatic stress disorder: alterations in functional connectivityJudith K Daniels
Department of Psychiatry, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ont, Canada
J Psychiatry Neurosci 35:258-66. 2010....
Recall of emotional states in posttraumatic stress disorder: an fMRI investigationRuth A Lanius
Department of Psychiatry, University of Western Ontario, London, Ontario, Canada
Biol Psychiatry 53:204-10. 2003..Thalamic and anterior cingulate dysfunction may underlie emotion dysregulation often observed clinically in PTSD...
Neural correlates of self-reflection in post-traumatic stress disorderR L Bluhm
Department of Philosophy and Religious Studies, Old Dominion University, Norfolk, VA, USA
Acta Psychiatr Scand 125:238-46. 2012..We hypothesized that individuals with PTSD would differ from controls in functional activation of the MPFC and PCC during SRP...
Emotion modulation in PTSD: Clinical and neurobiological evidence for a dissociative subtypeRuth A Lanius
Department of Psychiatry, The University of Western Ontario, London, Canada
Am J Psychiatry 167:640-7. 2010..These findings have important implications for treatment of PTSD, including the need to assess patients with PTSD for dissociative symptoms and to incorporate the treatment of dissociative symptoms into stage-oriented trauma treatment...
Cognitive distortions in an acutely traumatized sample: an investigation of predictive power and neural correlatesJ K Daniels
Department of Psychiatry, The University of Western Ontario, University Hospital, London, Ontario, Canada
Psychol Med 41:2149-57. 2011..Previous studies have shown that cognitive distortions in the early aftermath of traumatic events can predict future PTSD severity but, to date, no studies have investigated the neural correlates of this association...
Spontaneous low-frequency fluctuations in the BOLD signal in schizophrenic patients: anomalies in the default networkRobyn L Bluhm
Department of Psychiatry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Canada
Schizophr Bull 33:1004-12. 2007..Because these data suggest significant abnormalities in resting-state neural networks in schizophrenia, further investigations of spontaneous slow fluctuations of the BOLD signal seem warranted in this population...
Toward a psychobiology of posttraumatic self-dysregulation: reexperiencing, hyperarousal, dissociation, and emotional numbingPaul A Frewen
Department of Psychology, The University of Western Ontario (UWO, N6A 5C2 London, Ontario, Canada
Ann N Y Acad Sci 1071:110-24. 2006..We conclude by discussing the clinical significance of this framework for psychological assessment and treatment of posttrauma psychopathology...
Meta-analysis of alexithymia in posttraumatic stress disorderPaul A Frewen
Department of Psychology, The University of Western Ontario, Ontario, Canada
J Trauma Stress 21:243-6. 2008..A large effect size was found associating PTSD with alexithymia. Effect sizes were higher in studies of male combat PTSD samples in comparison with studies of other PTSD samples. Clinical and research directions are discussed...
Neuroimaging studies of psychological interventions for mood and anxiety disorders: empirical and methodological reviewPaul A Frewen
Department of Psychology, The University of Western Ontario, Canada
Clin Psychol Rev 28:228-46. 2008..Specific recommendations for future studies are outlined, and the clinical and theoretical significance of this research is discussed...
Default mode network connectivity: effects of age, sex, and analytic approachRobyn L Bluhm
Department of Psychiatry, Schulich School of Medicine and Dentistry, Canada
Neuroreport 19:887-91. 2008..Age and sex differences were small and there was less agreement between analytic techniques regarding age and sex effects than regarding default mode network structure...
Psychologic trauma, posttraumatic stress disorder, and dermatologyMadhulika A Gupta
Department of Psychiatry, University of Western Ontario, London, Ontario, Canada
Dermatol Clin 23:649-56. 2005....
Neurobiology of dissociation: unity and disunity in mind-body-brainPaul A Frewen
Department of Psychology, The University of Western Ontario, 339 Windermere Road, P.O. Box 5339, London, Ontario N6A 5A5, Canada
Psychiatr Clin North Am 29:113-28, ix. 2006
Clinical and neural correlates of alexithymia in posttraumatic stress disorderPaul A Frewen
Department of Psychology, University of Western Ontario, London, Ontario, Canada
J Abnorm Psychol 117:171-81. 2008..Clinical and theoretical implications and future research directions are discussed...
Neural correlates of reexperiencing, avoidance, and dissociation in PTSD: symptom dimensions and emotion dysregulation in responses to script-driven trauma imageryJames W Hopper
Behavioral Psychopharmacology Research Laboratory, Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont, MA 02478, USA
J Trauma Stress 20:713-25. 2007..Theoretical and clinical implications are discussed, particularly with respect to an emotion-dysregulation account of PTSD...
Functional magnetic resonance imaging: application to posttraumatic stress disorderKatherine H Taber
Department of Radiology, Baylor College of Medicine, Houston, Texas 77030-3498, USA
J Neuropsychiatry Clin Neurosci 15:125-9. 2003
Stage-oriented trauma treatment using dialectical behaviour therapyRuth A Lanius
Can J Psychiatry 48:126-7. 2003
