Anthony E Lang

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi request reprint Deep brain stimulation: preoperative issues
    Anthony E Lang
    Department of Neurology, Toronto Western Hospital, Toronto, Ontario, Canada
    Mov Disord 21:S171-96. 2006
  2. doi request reprint Trial designs used to study neuroprotective therapy in Parkinson's disease
    Anthony E Lang
    Morton and Gloria Shulman Movement Disorders Clinic and the Edmond J Safra Program in Parkinson s Disease, Toronto Western Hospital, Toronto, Ontario, Canada
    Mov Disord 28:86-95. 2013
  3. ncbi request reprint Corticobasal degeneration: selected developments
    Anthony E Lang
    Department of Medicine Neurology, University of Toronto, Toronto Western Hospital, Toronto, Ontario, Canada
    Mov Disord 18:S51-6. 2003
  4. doi request reprint A critical appraisal of the premotor symptoms of Parkinson's disease: potential usefulness in early diagnosis and design of neuroprotective trials
    Anthony E Lang
    University of Toronto, Toronto, Ontario, Canada
    Mov Disord 26:775-83. 2011
  5. doi request reprint Psychogenic movement disorders: past developments, current status, and future directions
    Anthony E Lang
    Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    Mov Disord 26:1175-86. 2011
  6. doi request reprint When and how should treatment be started in Parkinson disease?
    Anthony E Lang
    Toronto Western Hospital, University of Toronto, Canada
    Neurology 72:S39-43. 2009
  7. ncbi request reprint The progression of Parkinson disease: a hypothesis
    Anthony E Lang
    Movement Disorders Centre, Toronto Western Hospital, Toronto, ON, Canada
    Neurology 68:948-52. 2007
  8. ncbi request reprint Deep brain stimulation for Parkinson's disease: patient selection and evaluation
    Anthony E Lang
    Division of Neurology, Toronto Western Hospital Movement and University of Toronto, Ontario, Canada
    Mov Disord 17:S94-101. 2002
  9. ncbi request reprint Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease
    Anthony E Lang
    Toronto Western Hospital, University of Toronto, Ontario, Canada
    Ann Neurol 59:459-66. 2006
  10. ncbi request reprint Challenges in Parkinson's disease: restoration of the nigrostriatal dopamine system is not enough
    Anthony E Lang
    Movement Disorders Clinic, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    Lancet Neurol 3:309-16. 2004

Detail Information

Publications113 found, 100 shown here

  1. ncbi request reprint Deep brain stimulation: preoperative issues
    Anthony E Lang
    Department of Neurology, Toronto Western Hospital, Toronto, Ontario, Canada
    Mov Disord 21:S171-96. 2006
    ..It outlines answers to a series of questions developed to address all aspects of deep brain stimulation preoperative decision-making...
  2. doi request reprint Trial designs used to study neuroprotective therapy in Parkinson's disease
    Anthony E Lang
    Morton and Gloria Shulman Movement Disorders Clinic and the Edmond J Safra Program in Parkinson s Disease, Toronto Western Hospital, Toronto, Ontario, Canada
    Mov Disord 28:86-95. 2013
    ....
  3. ncbi request reprint Corticobasal degeneration: selected developments
    Anthony E Lang
    Department of Medicine Neurology, University of Toronto, Toronto Western Hospital, Toronto, Ontario, Canada
    Mov Disord 18:S51-6. 2003
    ..Even if they are eventually found to be distinct disorders, treatments that alter the progression of one may have similar ameliorative effects on the other. Each of these issues are discussed in this selective review of CBD...
  4. doi request reprint A critical appraisal of the premotor symptoms of Parkinson's disease: potential usefulness in early diagnosis and design of neuroprotective trials
    Anthony E Lang
    University of Toronto, Toronto, Ontario, Canada
    Mov Disord 26:775-83. 2011
    ..This article will review the current status of premotor symptoms of Parkinson's disease and discuss their potential for early diagnosis and the design of neuroprotective trials...
  5. doi request reprint Psychogenic movement disorders: past developments, current status, and future directions
    Anthony E Lang
    Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    Mov Disord 26:1175-86. 2011
    ..Given the personal and societal impact of these problems, further advances in our understanding of their pathogenesis and the subsequent development of effective therapies are sorely needed...
  6. doi request reprint When and how should treatment be started in Parkinson disease?
    Anthony E Lang
    Toronto Western Hospital, University of Toronto, Canada
    Neurology 72:S39-43. 2009
    ..This review will highlight these and other issues that must be considered when deciding on the early treatment of PD...
  7. ncbi request reprint The progression of Parkinson disease: a hypothesis
    Anthony E Lang
    Movement Disorders Centre, Toronto Western Hospital, Toronto, ON, Canada
    Neurology 68:948-52. 2007
    ..This hypothesis has implications for the development of disease-modifying therapy and the interpretation of endpoints of clinical trials evaluating the efficacy of such treatments...
  8. ncbi request reprint Deep brain stimulation for Parkinson's disease: patient selection and evaluation
    Anthony E Lang
    Division of Neurology, Toronto Western Hospital Movement and University of Toronto, Ontario, Canada
    Mov Disord 17:S94-101. 2002
    ....
  9. ncbi request reprint Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease
    Anthony E Lang
    Toronto Western Hospital, University of Toronto, Ontario, Canada
    Ann Neurol 59:459-66. 2006
    ..This randomized controlled clinical trial was designed to confirm initial clinical benefits observed in a small, open-label trial using intraputamenal (Ipu) infusion of recombinant human GDNF (liatermin)...
  10. ncbi request reprint Challenges in Parkinson's disease: restoration of the nigrostriatal dopamine system is not enough
    Anthony E Lang
    Movement Disorders Clinic, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    Lancet Neurol 3:309-16. 2004
    ..Knowledge of the widespread, multisystem nature of the neurodegeneration that accounts for these problems suggests that restoration of the nigrostriatal dopamine system should not be the ultimate goal of future research...
  11. ncbi request reprint Beta oscillatory activity in the subthalamic nucleus and its relation to dopaminergic response in Parkinson's disease
    Moran Weinberger
    Department of Physiology, Med Sci Building 3302, 1 King s College Circle, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Neurophysiol 96:3248-56. 2006
    ..The study also suggests that LFP beta oscillatory activity is generated largely within the dorsal portion of the STN and can produce synchronous oscillatory activity of the local neuronal population...
  12. doi request reprint Electrophysiological features of myoclonus-dystonia
    Jie Yuan Li
    Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Mov Disord 23:2055-61. 2008
    ....
  13. pmc Stimulation of the subthalamic nucleus and impulsivity: release your horses
    Benedicte Ballanger
    Division of Brain, Imaging and Behaviour Systems Neuroscience, Toronto Western Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Ann Neurol 66:817-24. 2009
    ....
  14. ncbi request reprint Cerebral blood flow changes induced by pedunculopontine nucleus stimulation in patients with advanced Parkinson's disease: a [(15)O] H2O PET study
    Benedicte Ballanger
    Toronto Western Research Institute Division of Brain, Imaging and Behaviour Systems Neuroscience, UHN, University of Toronto, Toronto, Ontario, Canada
    Hum Brain Mapp 30:3901-9. 2009
    ..Whether these findings are associated with the DBS-PPN clinical effect remains to be proven. However, they suggest that PPN modulation may induce functional changes in neural networks associated with the control of lower limb movements...
  15. ncbi request reprint Involvement of human thalamus in the preparation of self-paced movement
    Guillermo Paradiso
    The Krembil Neuroscience Centre and Toronto Western Research Institute, Toronto, Ontario, Canada
    Brain 127:2717-31. 2004
    ..Different cortico-subcortical circuits may mediate alpha and beta oscillations. During movement preparation, the motor thalamus and the supplementary motor area predominantly interact in the beta band...
  16. ncbi request reprint Neuronal firing rates and patterns in the globus pallidus internus of patients with cervical dystonia differ from those with Parkinson's disease
    Joyce K H Tang
    Department of Physiology, University of Toronto, Toronto, ON, Canada
    J Neurophysiol 98:720-9. 2007
    ..These findings suggest that alterations in both firing rate and firing pattern may underlie the differing motor symptoms associated with these two movement disorders...
  17. pmc Prefrontal dopaminergic receptor abnormalities and executive functions in Parkinson's disease
    Ji Hyun Ko
    Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Ontario, Canada
    Hum Brain Mapp 34:1591-604. 2013
    ..These observations provide important insights on the pathophysiology of cognitive dysfunction in PD...
  18. ncbi request reprint Involvement of the basal ganglia and cerebellar motor pathways in the preparation of self-initiated and externally triggered movements in humans
    Jamie Purzner
    The Krembil Neuroscience Centre and Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada M5T 2S8
    J Neurosci 27:6029-36. 2007
    ..The CTC pathway is involved in the preparation of self-paced but not externally cued movements, although the pathway may still be involved in the execution of these movements...
  19. doi request reprint Predictors of time to requiring dopaminergic treatment in 2 Parkinson's disease cohorts
    Connie Marras
    Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, Toronto, Ontario, Canada
    Mov Disord 26:608-13. 2011
    ..We suspect that individuals employed full time may have a lower threshold for requiring dopaminergic therapy because of occupational demands...
  20. doi request reprint LRRK2 and Parkin mutations in a family with parkinsonism-Lack of genotype-phenotype correlation
    Connie Marras
    Movement Disorders Centre, Toronto Western Hospital, Toronto, Canada
    Neurobiol Aging 31:721-2. 2010
    ..In the combined mutation carriers the age at onset and clinical course was highly variable and not always younger than in the carriers of LRRK2 G2019S mutations alone...
  21. ncbi request reprint Selective enhancement of rapid eye movement sleep by deep brain stimulation of the human pons
    Andrew S Lim
    Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Ann Neurol 66:110-4. 2009
    ..This represents the first demonstration that DBS can selectively modulate human sleep, and it supports an important role for the pedunculopontine nucleus region in modulating human REM sleep. Ann Neurol 2009;66:110-114...
  22. doi request reprint The nature and time course of cortical activation following subthalamic stimulation in Parkinson's disease
    Renju Kuriakose
    Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada M5T 2S8
    Cereb Cortex 20:1926-36. 2010
    ..Cortical activation may be related to the clinical effects of STN DBS in PD...
  23. pmc Extrastriatal dopaminergic abnormalities of DA homeostasis in Parkinson's patients with medication-induced pathological gambling: a [11C] FLB-457 and PET study
    Nicola J Ray
    Morton and Gloria Shulman Movement Disorder Unit and E J Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Toronto, Ontario, Canada
    Neurobiol Dis 48:519-25. 2012
    ..Thus, altered striatal and cortical DA homeostasis may incur vulnerability for the development of PG in PD, linked with the impulsive personality trait...
  24. ncbi request reprint Changes in cortical and pallidal oscillatory activity during the execution of a sensory trick in patients with cervical dystonia
    Joyce K H Tang
    Department of Physiology, Med Sci Bldg 3302, 1 King s College Circle, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    Exp Neurol 204:845-8. 2007
    ..These preliminary findings suggest a role for 4-8 Hz frequency synchronization in the pathophysiology of dystonia...
  25. doi request reprint Unilateral subdural motor cortex stimulation improves essential tremor but not Parkinson's disease
    Elena Moro
    Movement Disorders Centre, Division of Neurology, Department of Medicine, University of Toronto, Toronto Western Hospital, University Health Network, Toronto, ON M5T2S8, Canada
    Brain 134:2096-105. 2011
    ..These findings suggest that unilateral subdural motor cortex stimulation may be useful for contralateral hand tremor in selected patients with essential tremor but was not effective in improving parkinsonian signs in our series...
  26. ncbi request reprint Levodopa response in long-term bilateral subthalamic stimulation for Parkinson's disease
    Panida Piboolnurak
    Movement Disorders Center, Division of Neurology, University of Toronto, Toronto Western Hospital, Toronto, Ontario, Canada
    Mov Disord 22:990-7. 2007
    ..1% at 3 years and 19.2% at 5 years). Anti-PD drugs were significantly reduced by 47.9% at 3 years and 39.8% at 5 years. However, the magnitude of the preoperative response to levodopa did not predict DBS benefit at 3 and 5 years...
  27. ncbi request reprint Cortical and spinal abnormalities in psychogenic dystonia
    Alberto J Espay
    Toronto Western Research Institute, University of Toronto, Toronto, Ontario, Canada
    Ann Neurol 59:825-34. 2006
    ..We tested the hypothesis that aberrant sensory input associated with abnormal posture may cause similar abnormalities by testing patients with psychogenic dystonia...
  28. doi request reprint The nonmotor symptoms of Parkinson's disease--an overview
    Shen Yang Lim
    Movement Disorders Centre, Toronto Western Hospital, Ontario, Canada
    Mov Disord 25:S123-30. 2010
    ..The increased focus on these important clinical features represents a major advance in the care of PD patients. In this article, we provide an overview of recent developments in the field...
  29. ncbi request reprint Subthalamic nucleus deep brain stimulation for parkinson's disease after successful pallidotomy: clinical and electrophysiological observations
    Galit Kleiner-Fisman
    Division of Neurology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    Mov Disord 19:1209-14. 2004
    ..017, 0.005). There were no side-to-side differences clinically or in the STN neuronal firing rates and patterns. Bilateral STN DBS is safe and efficacious in improving motor symptoms in patients with prior pallidotomy...
  30. ncbi request reprint Neuronal activity in the globus pallidus of multiple system atrophy patients
    Luiz C M Pereira
    Department of Surgery, Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada
    Mov Disord 19:1485-92. 2004
    ....
  31. ncbi request reprint Subdural motor cortex stimulation in Parkinson's disease does not modify movement-related rCBF pattern
    Antonio P Strafella
    Movement Disorders Center, Division of Neurology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    Mov Disord 22:2113-6. 2007
    ..We conclude that while MCS may be a simpler and safer surgical procedure than DBS of STN, it failed to provide evidence of clear effect on motor performance and movement-related activation pattern in patients with advanced PD...
  32. ncbi request reprint Combined insular and striatal dopamine dysfunction are associated with executive deficits in Parkinson's disease with mild cognitive impairment
    Leigh Christopher
    1 Morton and Gloria Shulman Movement Disorder Unit and E J Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Ontario, M5T 2S8, Canada
    Brain 137:565-75. 2014
    ..Furthermore, these findings suggest a crucial and direct role for dopaminergic modulation in the insula in facilitating cognitive function. ..
  33. doi request reprint A comparison of treatment thresholds in two large Parkinson's disease clinical trial cohorts
    Connie Marras
    Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, Toronto, Ontario, Canada
    Mov Disord 24:2370-8. 2009
    ..This may relate to changes in philosophies with respect to starting treatment for Parkinson's disease, but the factors underlying this change remain to be elucidated...
  34. ncbi request reprint Childhood onset in familial prion disease with a novel mutation in the PRNP gene
    Ekaterina Rogaeva
    Centre for Research in Neurodegenerative Diseases, Department of Medicine, Toronto, Ontario, Canada
    Arch Neurol 63:1016-21. 2006
    ..Up to 15% of cases of prion diseases are due to the autosomal dominant inheritance of coding PRNP mutations...
  35. ncbi request reprint Psychiatric symptoms following surgery for Parkinson's disease with an emphasis on subthalamic stimulation
    Valerie Voon
    Department of Psychiatry, Toronto Western Hospital, UHN, Toronto, Canada
    Adv Neurol 96:130-47. 2005
    ..The paucity of the literature underscores the need for well-designed studies on psychiatric issues investigating both pathophysiology and clinical outcomes...
  36. doi request reprint Involvement of the cerebellothalamocortical pathway in Parkinson disease
    Zhen Ni
    Division of Neurology, Department of Medicine, University of Toronto and Toronto Western Research Institute, Krembil Neuroscience Centre, University Health Network, Toronto, Ontario, Canada
    Ann Neurol 68:816-24. 2010
    ..We tested whether M1 or cerebellar stimulation can reset PD tremor, and investigated the excitability of the CTC pathway in PD...
  37. ncbi request reprint Psychiatric symptoms in patients with Parkinson disease presenting for deep brain stimulation surgery
    Valerie Voon
    Department of Psychiatry, Toronto Western Hospital, University Health Network, University of Toronto, Ontario, Canada
    J Neurosurg 103:246-51. 2005
    ..In the present study, preoperative psychiatric symptoms were systematically assessed in patients with PD presenting for routine preoperative psychiatric assessment...
  38. doi request reprint Long-term effect of unilateral pallidotomy on levodopa-induced dyskinesia
    Galit Kleiner-Fisman
    Morton and Gloria Shulman Movement Disorders Center, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    Mov Disord 25:1496-8. 2010
    ..Though sample size was small, there was a trend towards a reduction in LID lasting up to 12 years suggesting that posteroventral pallidotomy may provide sustained benefit in reducing LID...
  39. ncbi request reprint Movement disorder society unified Parkinson disease rating scale experiences in daily living: longitudinal changes and correlation with other assessments
    Anthony E Lang
    Morton and Gloria Shulman Movement Disorders Clinic and the Edmond J Safra Program in Parkinson s Disease, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    Mov Disord 28:1980-6. 2013
    ..The nM-EDL and M-EDL components of the MDS-UPDRS provide an effective, relevant measure of change in the broad spectrum of symptoms of PD over the first decade of the disease...
  40. ncbi request reprint Motor cortex plasticity in Parkinson's disease and levodopa-induced dyskinesias
    Francesca Morgante
    Division of Neurology and Toronto Western Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Brain 129:1059-69. 2006
    ..Abnormal synaptic plasticity in the motor cortex may play a role in the development of LID...
  41. ncbi request reprint Treatment of progressive supranuclear palsy and corticobasal degeneration
    Anthony E Lang
    Toronto Western Hospital, Movement Disorders Clinic, Ontario, Canada
    Mov Disord 20:S83-91. 2005
    ..The similarities in the molecular pathology of these four-repeat tauopathies suggests that important advances in the management of one will have a definite impact on the treatment of the other...
  42. ncbi request reprint Genetic association study of PINK1 coding polymorphisms in Parkinson's disease
    Justus L Groen
    Centre for Research in Neurodegenerative Diseases, Department of Medicine, University of Toronto, 6 Queen s Park Crescent West, Toronto, Ont, Canada M5S 3H2
    Neurosci Lett 372:226-9. 2004
    ..19). Nevertheless, it remains to be evaluated whether PINK1 variations contribute to the risk of common late onset sporadic PD...
  43. doi request reprint Impairments of speed and amplitude of movement in Parkinson's disease: a pilot study
    Alberto J Espay
    Toronto Western Research Institute, Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Mov Disord 24:1001-8. 2009
    ..Levodopa, however, normalized speed to a greater extent than amplitude. Our observations suggest that amplitude and speed impairments may be associated with different functional aspects in PD and deserve separate clinical assessment...
  44. ncbi request reprint Predictors of deterioration in health-related quality of life in Parkinson's disease: results from the DATATOP trial
    Connie Marras
    Division of Neurology, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Mov Disord 23:653-9; quiz 776. 2008
    ..Our focus in clinical care needs to be broadened beyond assessing and treating Parkinsonism, recognizing the impact of mood, cognition and function on HRQOL...
  45. doi request reprint Levodopa-related motor complications--phenomenology
    Susan H Fox
    Division of Neurology, Toronto Western Hospital, Movement Disorders Clinic, University of Toronto, Toronto, Ontario, Canada
    Mov Disord 23:S509-14. 2008
    ..These include fluctuations in FD symptoms termed motor fluctuations, as well as non-motor symptoms, termed non-motor fluctuations. Here we review the phenomenology and methods of assessing these levodopa-related complications...
  46. ncbi request reprint Stimulation of the subthalamic nucleus in Parkinson's disease does not produce striatal dopamine release
    Aviva Abosch
    Department of Surgery, Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, and University Health Network, University of Toronto, Toronto, Ontario, Canada
    Neurosurgery 53:1095-102; discussion 1102-5. 2003
    ..We sought to determine whether STN stimulation could release endogenous striatal dopamine...
  47. ncbi request reprint Analysis of the PINK1 gene in a large cohort of cases with Parkinson disease
    Ekaterina Rogaeva
    Centre for Research in Neurodegenerative Diseases and Division of Neurology, Department of Medicine, Toronto Western Hospital, University of Toronto, Ontario, Canada
    Arch Neurol 61:1898-904. 2004
    ..Mutations in the PTEN-induced kinase (PINK1) gene located within the PARK6 locus on chromosome 1p35-p36 have recently been identified in patients with recessive early-onset Parkinson disease...
  48. ncbi request reprint Bilateral globus pallidus stimulation for Huntington's disease
    Elena Moro
    Movement Disorders Center, Toronto Western Hospital, Toronto, Ontario, Canada
    Ann Neurol 56:290-4. 2004
    ..Adjustment of stimulation parameters in GPi DBS may have the potential to optimize the motor response in HD, improving chorea without aggravating bradykinesia...
  49. ncbi request reprint Is there seasonal variation in risk of Parkinson's disease?
    Ronald B Postuma
    Department of Neurology, McGill University, Montreal General Hospital, Montreal, Quebec, Canada
    Mov Disord 22:1097-101. 2007
    ..We found no evidence of systematic seasonal variation in PD incidence by birth date, or of clustering of birth dates during influenza pandemic years in PD patients...
  50. doi request reprint Overview of the extranigral aspects of Parkinson disease
    Shen Yang Lim
    Movement Disorders Centre, Toronto Western Hospital, 399 Bathurst St, Toronto, Ontario M5T 2S8, Canada
    Arch Neurol 66:167-72. 2009
    ..Later-stage features often contribute markedly to disability and impaired quality of life and, therefore, represent an important future therapeutic challenge...
  51. ncbi request reprint Subthalamic nucleus stimulation: improvements in outcome with reprogramming
    Elena Moro
    Movement Disorders Center and Department of Neurosurgery, Toronto Western Hospital, University Health Network, University of Toronto, 399 Bathurst Street, Toronto, Ontario
    Arch Neurol 63:1266-72. 2006
    ..Even when the electrode is well positioned in the target, the optimization of clinical results depends on careful programming of electrical parameters and changes in antiparkinsonian drug dosages...
  52. ncbi request reprint Pallidal deep brain stimulation influences both reflexive and voluntary saccades in Huntington's disease
    Adrian P Fawcett
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Mov Disord 20:371-7. 2005
    ..Our data demonstrate a task-specific improvement of oculomotor deficits in this HD patient with pallidal DBS, supporting a role of GPi in oculomotor control...
  53. ncbi request reprint Motor cortical stimulation for parkinsonism in multiple system atrophy
    Galit Kleiner-Fisman
    Division of Neurology and Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario
    Arch Neurol 60:1554-8. 2003
    ..We hypothesized that direct cortical stimulation could alleviate the disability of the treatment-refractory parkinsonian symptoms commonly present in MSA...
  54. ncbi request reprint Firing rates of pallidal neurons are similar in Huntington's and Parkinson's disease patients
    Joyce K H Tang
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada, M5S 1A8
    Exp Brain Res 166:230-6. 2005
    ..Furthermore, the findings did reveal a difference between firing patterns in the HD and PD groups, thereby supporting the role of altered firing patterns in the pathophysiology of these diseases...
  55. doi request reprint Impact of mild cognitive impairment on health-related quality of life in Parkinson's disease
    William Reginold
    Toronto Western Hospital, Toronto, Ont, Canada
    Dement Geriatr Cogn Disord 36:67-75. 2013
    ..To assess the impact of mild cognitive impairment (MCI) or cognitive decline on health-related quality of life (HR-QOL) in Parkinson's disease (PD)...
  56. ncbi request reprint The value of GRE, ADC and routine MRI in distinguishing Parkinsonian disorders
    Pettarusp M Wadia
    Movement Disorders Center and the Edmond J Safra Program in Parkinson s Disease, Division of Neurology, University Health Network, University of Toronto, Canada Department of Neurology, Jaslok Hospital and Research Institute, Mumbai, India
    Can J Neurol Sci 40:389-402. 2013
    ..To study different radiological signs and sequences including apparent diffusion coefficient (ADC) and gradient echo (GRE) to differentiate degenerative parkinsonian syndromes...
  57. doi request reprint rCBF changes associated with PPN stimulation in a patient with Parkinson's disease: a PET study
    Antonio P Strafella
    Movement Disorders Center, Toronto Western Hospital, Division of Neurology, University of Toronto, Toronto, Ontario, Canada
    Mov Disord 23:1051-4. 2008
    ....
  58. pmc Caffeine for treatment of Parkinson disease: a randomized controlled trial
    Ronald B Postuma
    Department of Neurology, McGill University, Montreal General Hospital, Montreal, Canada
    Neurology 79:651-8. 2012
    ..Epidemiologic studies consistently link caffeine, a nonselective adenosine antagonist, to lower risk of Parkinson disease (PD). However, the symptomatic effects of caffeine in PD have not been adequately evaluated...
  59. ncbi request reprint Rapidly progressive behavioral changes and parkinsonism in a 68-year-old man
    Galit Kleiner-Fisman
    Department of Medicine, Division of Neurology, Toronto Western Hospital, Toronto, Ontario, Canada
    Mov Disord 19:534-43. 2004
  60. doi request reprint Reduced intracortical and interhemispheric inhibitions in corticobasal syndrome
    Pramod Kr Pal
    Division of Neurology and Toronto Western Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Clin Neurophysiol 25:304-12. 2008
    ..In conclusion, CBS patients had deficits in intracortical and interhemispheric inhibition in the representations for both distal and proximal upper limb muscles bilaterally with relative sparing of motor cortical output pathways...
  61. pmc Dopamine agonists diminish value sensitivity of the orbitofrontal cortex: a trigger for pathological gambling in Parkinson's disease?
    Thilo van Eimeren
    Division of Brain, Imaging and Behaviour Systems Neuroscience, BIB SN, Toronto Western Research Institute, University of Toronto, Toronto, ON, Canada
    Neuropsychopharmacology 34:2758-66. 2009
    ..Our findings raise the question of whether pathological gambling may in part stem from an impaired capacity of the OFC to guide behavior when facing negative consequences...
  62. ncbi request reprint Extrastriatal dopaminergic dysfunction in tourette syndrome
    Thomas D L Steeves
    Division of Neurology, Toronto Western Hospital, University Health Network, University of Toronto, Ontario, Canada
    Ann Neurol 67:170-81. 2010
    ..A substantial body of evidence has also accrued to implicate regions outside the striatum in the generation of tics...
  63. ncbi request reprint Non-dopaminergic treatments in development for Parkinson's disease
    Susan H Fox
    Movement Disorders Clinic, Division of Neurology, University of Toronto, Toronto, ON, Canada
    Lancet Neurol 7:927-38. 2008
    ..Here, we review novel non-dopaminergic approaches that are in at least phase II clinical development for the treatment of PD...
  64. ncbi request reprint Homocysteine and levodopa: should Parkinson disease patients receive preventative therapy?
    Ronald B Postuma
    Morton and Gloria Shulman Movement Disorders Center, Toronto Western Hospital, Ontario, Canada
    Neurology 63:886-91. 2004
    ..At present, no controlled prospective studies have evaluated this phenomenon, although they are ongoing...
  65. ncbi request reprint Analysis of the glucocerebrosidase gene in Parkinson's disease
    Christine Sato
    Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada
    Mov Disord 20:367-70. 2005
    ..Our results demonstrate a marginally significant association of GBA mutations with PD and suggest that variations in the GBA gene may constitute a rare susceptibility factor for PD (P = 0.048)...
  66. ncbi request reprint Homozygous and heterozygous PINK1 mutations: considerations for diagnosis and care of Parkinson's disease patients
    Cindy Zadikoff
    Movement Disorders Centre, Toronto Western Hospital, Toronto, Ontario, Canada
    Mov Disord 21:875-9. 2006
    ..We describe two unrelated cases with PINK1 mutations (homozygous nonsense and heterozygous missense) that highlight issues regarding the role of heterozygous mutations and the utility of genetic screening in patient care...
  67. ncbi request reprint Unilateral versus bilateral tasks in early asymmetric Parkinson's disease: differential effects on bradykinesia
    Asha Kishore
    Division of Neurology, Department of Medicine, Toronto Western Hospital, Toronto, Ontario, Canada
    Mov Disord 22:328-33. 2007
    ..This observation also highlights the need to perform tasks of bradykinesia in one limb at a time for best accuracy...
  68. ncbi request reprint Orthostatic tremor in progressive supranuclear palsy
    Rob M A De Bie
    Movement Disorders Center, Division of Neurology, Toronto Western Hospital, Toronto, Ontario, Canada
    Mov Disord 22:1192-4. 2007
    ..quot; We describe a patient with OT, with postural tremor of the arms and restless legs syndrome (RLS), who developed features typical of progressive supranuclear palsy (PSP). PSP can be accompanied by OT...
  69. ncbi request reprint Localization of clinically effective stimulating electrodes in the human subthalamic nucleus on magnetic resonance imaging
    Jean A Saint-Cyr
    Department of Surgery, Division of Neurosurgery, University of Toronto and University Health Network, Toronto, Ontario, Canada
    J Neurosurg 97:1152-66. 2002
    ..The authors sought to determine the location of deep brain stimulation (DBS) electrodes that were most effective in treating Parkinson disease (PD)...
  70. ncbi request reprint Long-term follow-up of thalamic deep brain stimulation for essential and parkinsonian tremor
    Rajeev Kumar
    Division of Neurology, Faculty of Medicine, University of Toronto, Canada
    Neurology 61:1601-4. 2003
    ..Two of five patients with essential tremor had contralateral tremor improvement after ongoing stimulation for 2 years; two developed marked tolerance to DBS...
  71. ncbi request reprint Long-term follow up of bilateral deep brain stimulation of the subthalamic nucleus in patients with advanced Parkinson disease
    Galit Kleiner-Fisman
    Division of Neurology and Neurosurgery, Toronto Western Hospital, University of Toronto, Ontario, Canada
    J Neurosurg 99:489-95. 2003
    ..The authors present the long-term results of a cohort of 25 individuals who underwent bilateral DBS of the STN between 1996 and 2001 and were followed up for 1 year or longer after implantation of the stimulator...
  72. doi request reprint Long-term results of a multicenter study on subthalamic and pallidal stimulation in Parkinson's disease
    Elena Moro
    Toronto Western Hospital, Movement Disorders Center, University of Toronto and University Health Network, Toronto, Ontario, Canada
    Mov Disord 25:578-86. 2010
    ..Although the surgical targets were not randomized, there was a trend to a better outcome of motor signs in the STN-DBS patients and fewer adverse events in the GPi-DBS group...
  73. ncbi request reprint Primary dystonia is more responsive than secondary dystonia to pallidal interventions: outcome after pallidotomy or pallidal deep brain stimulation
    Hazem A Eltahawy
    Division of Neurosurgery, Toronto Western Hospital, Toronto, Ontario, Canada
    Neurosurgery 54:613-19; discussion 619-21. 2004
    ..In this study, we assessed the postoperative outcome of patients with primary and secondary dystonia undergoing pallidotomy or pallidal deep brain stimulation...
  74. pmc Characterization of REM-sleep associated ponto-geniculo-occipital waves in the human pons
    Andrew S Lim
    Division of Neurology, Department of Medicine, University of Toronto, Ontario, Canada
    Sleep 30:823-7. 2007
    ..We sought to identify and characterize human PGO waves...
  75. ncbi request reprint Dependence of subthalamic nucleus oscillations on movement and dopamine in Parkinson's disease
    Ron Levy
    Department of Physiology, University of Toronto, Toronto, Canada
    Brain 125:1196-209. 2002
    ....
  76. ncbi request reprint Neonatal ablation of the nigrostriatal dopamine pathway does not influence limb development in rats
    Matthew O Hebb
    Division of Neurosurgery, University of Toronto, Toronto, Ontario, M5T 2S8, Canada
    Exp Neurol 177:547-56. 2002
    ..The results of this study indicate that early skeletal development in rats is not affected by loss of nigrostriatal dopamine per se, but is markedly attenuated by corticospinal lesions sustained during the neonatal period...
  77. ncbi request reprint Myoclonus in parkinsonian disorders
    Mohamed Shafiq
    Department of Medicine Neurology, Toronto Western Hospital, Toronto, Ontario, Canada
    Adv Neurol 89:77-83. 2002
  78. doi request reprint Translational research in neurology and neuroscience 2011: movement disorders
    Christine Klein
    Section of Clinical and Molecular Neurogenetics, Department of Neurology, University of Lubeck, Lubeck, Germany
    Arch Neurol 68:709-16. 2011
    ..Aetiology and pathogenesis, biomarker directions, and causal treatment opportunities are discussed for each disease, followed by a brief discussion drawing attention to important translational initiatives...
  79. ncbi request reprint Deep brain stimulation for Parkinson's disease dissociates mood and motor circuits: a functional MRI case study
    Taresa Stefurak
    Rotman Research Institute, University of Toronto, Toronto, Ontario, Canada
    Mov Disord 18:1508-16. 2003
    ....
  80. ncbi request reprint Pallidal neuronal activity: implications for models of dystonia
    William D Hutchison
    Department of Surgery, Division of Neurosurgery and Toronto Western Research Institute, Toronto Western Hospital and Faculty of Medicine, University of Toronto, Ontario, Canada
    Ann Neurol 53:480-8. 2003
    ..The widely accepted pathophysiological models of dystonia that propose global decreases in basal ganglia output need to be viewed with caution in light of these findings...
  81. ncbi request reprint Tongue control for swallowing in Parkinson's disease: effects of age, rate, and stimulus consistency
    Pascal H H M van Lieshout
    Department of Speech Language Pathology, University of Toronto, and Toronto Western Hospital Research Institute, University Health Network, Toronto, Ontario, Canada
    Mov Disord 26:1725-9. 2011
    ..Efficient swallows require well-coordinated tongue movements during bolus flow, but little is known about such movements in Parkinson's disease...
  82. ncbi request reprint Antipsychotic use in older adults with Parkinson's disease
    Connie Marras
    Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, University Health Network, Toronto, Canada
    Mov Disord 22:319-23. 2007
    ..Typical antipsychotics are still commonly being chosen as first-line agents for older patients, indicating a need for interventions to improve practice...
  83. ncbi request reprint Punding prevalence in Parkinson's disease
    Janis M Miyasaki
    Movement Disorders Centre, Toronto Western Hospital, University Health Network, Krembil Neuroscience Centre, University of Toronto, Toronto, Canada
    Mov Disord 22:1179-81. 2007
    ..4%) in contrast with previous reports of 14%. Despite the low incidence, this behavior is disruptive and should be carefully elicited by physicians caring for Parkinson's disease patients...
  84. ncbi request reprint Does severity of Parkinson's disease vary according to season?
    Ronald B Postuma
    Department of Neurology, McGill University, Montreal General Hospital, Montreal, Quebec, Canada
    Mov Disord 20:476-9. 2005
    ..We found no evidence for seasonal fluctuation in the UPDRS scores, suggesting that, although considerable day-to-day variation may exist in PD, there is little monthly or seasonal variation...
  85. ncbi request reprint Subthalamic stimulation for Parkinson's disease--living better electrically?
    Anthony E Lang
    University of Toronto, Toronto
    N Engl J Med 349:1888-91. 2003
  86. ncbi request reprint Antidepressants in the treatment of psychosis with comorbid depression in Parkinson disease
    Valerie Voon
    University of Toronto, Toronto Western Hospital University Health Network, Ontario, Canada
    Clin Neuropharmacol 27:90-2. 2004
    ..Potential mechanisms implicated in the response of psychosis to antidepressants are discussed...
  87. ncbi request reprint Clinical findings in a large family with a parkin ex3delta40 mutation
    Renato P Munhoz
    Movement Disorders Centre, Toronto Western Hospital, and Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada
    Arch Neurol 61:701-4. 2004
    ..To describe a large consanguineous family in which inheritance of a 438- to 477-base pair deletion in exon 3 (Ex3Delta40) in the parkin gene resulted in parkinsonism (age range at onset, 24-32 years)...
  88. ncbi request reprint Progress in clinical neurosciences: a forum on the early management of Parkinson's disease
    Anthony E Lang
    Division of Neurology, Department of Medicine, University of Toronto, Toronto Western Hospital, Canada
    Can J Neurol Sci 32:277-86. 2005
    ..This report summarizes presentations and discussion dealing with these issues from a one-day symposium involving Canadian Movement Disorders neurologists...
  89. ncbi request reprint Corticobasal degeneration syndrome with basal ganglia calcification: Fahr's disease as a corticobasal look-alike?
    Anthony E Lang
    Movement Disorders Centre, Toronto Western Hospital, Toronto, Canada
    Mov Disord 18:351-2; author reply 352. 2003
  90. ncbi request reprint Combination of dopamine transporter and D2 receptor SPECT in the diagnostic evaluation of PD, MSA, and PSP
    Yun J Kim
    Morton and Gloria Shulman Movement Disorders Center and the Division of Neurology Department of Medicine, The Toronto Western Hospital, Toronto, Ontario, Canada
    Mov Disord 17:303-12. 2002
    ..These findings suggest that DAT SPECT may be useful in differentiating parkinsonism from controls and D2 SPECT in further differentiating MSA from Parkinson's disease and possibly PSP...
  91. ncbi request reprint Apraxia in movement disorders
    Cindy Zadikoff
    Morton and Gloria Shulman Movement Disorders Center, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    Brain 128:1480-97. 2005
    ..Finally, although apraxia results in clear disability in patients with the CBS, it is not clear how milder ideomotor apraxia found on specific testing contributes to patients' overall day-to-day motor disability...
  92. ncbi request reprint Neurodegenerative disease and the evolution of art: the effects of presumed corticobasal degeneration in a professional artist
    Galit Kleiner-Fisman
    Morton and Gloria Shulman Movement Disorders Center, Division of Neurology, The Toronto Hospital, University of Toronto, Western Division, 399 Bathurst Street, MP11 306, Toronto, Ontario M5T 2S8, Canada
    Mov Disord 18:294-302. 2003
    ..Our case study adds to the growing literature on the effects of brain damage on artistic expression in the graphic arts...
  93. ncbi request reprint Large deletions account for an increasing number of mutations in SGCE
    Fabin Han
    Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Mov Disord 23:456-60. 2008
    ..This is only the second report of intragenic deletions with SGCE and it highlights the need to include exonic copy number variation when performing mutational analysis of SGCE...
  94. ncbi request reprint Progression of dystonia in complex regional pain syndrome
    John C Morgan
    Neurology 64:2162-3. 2005
  95. ncbi request reprint Time to move beyond nigrostriatal dopamine deficiency in Parkinson's disease
    Anthony E Lang
    Ann Neurol 55:761-5. 2004
  96. ncbi request reprint Criteria for deep-brain stimulation in Parkinson's disease: review and analysis
    Elena Moro
    University of Toronto, Department of Medicine, Movement Disorders Center, 399 Bathurst Street, McL7 402, Canada
    Expert Rev Neurother 6:1695-705. 2006
    ..The recent observation that deep-brain stimulation of the pedunculopontine nucleus improves axial signs, possibly even in those less responsive to levodopa, brings new hope to the management of advanced Parkinson's disease...
  97. ncbi request reprint Pathological gambling in Parkinson's disease improves on chronic subthalamic nucleus stimulation
    Claire Ardouin
    Departement de Neurologie, CHU Grenoble, INSERM U318, Universite Joseph Fourier, Grenoble, France
    Mov Disord 21:1941-6. 2006
    ....
  98. ncbi request reprint Development of dyskinesias in a 5-year trial of ropinirole and L-dopa
    Olivier Rascol
    Clinical Investigation Centre, Department of Pharmacology and INSERM U455, Toulouse Hospital, Toulouse, France
    Mov Disord 21:1844-50. 2006
    ..Early use of ropinirole postpones the onset of dyskinesias, but these benefits decline when levodopa therapy is started, with no evidence of a subsequent rapid "catch-up" or a persisting preventive effect...
  99. ncbi request reprint Antidepressants and psychosis in Parkinson disease: a case series
    Valerie Voon
    Int J Geriatr Psychiatry 22:601-4. 2007
  100. ncbi request reprint Sustained relief of dystonia following cessation of deep brain stimulation
    Matthew O Hebb
    Division of Neurosurgery, Department of Surgery, Dalhousie University, Halifax, Nova Scotia, Canada
    Mov Disord 22:1958-62. 2007
    ....
  101. ncbi request reprint Severe multivalvular heart disease: a new complication of the ergot derivative dopamine agonists
    Judit Horvath
    Department of Neurology, University Hospital, Geneva, Switzerland
    Mov Disord 19:656-62. 2004
    ..Therefore, until more is known about the true prevalence of this side effect, we propose that an assessment of cardiac function be performed before and in the course of a long-term therapy with ergot derivative dopamine agonists...