E K Lambe

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi request reprint Hypocretin (orexin) induces calcium transients in single spines postsynaptic to identified thalamocortical boutons in prefrontal slice
    Evelyn K Lambe
    Department of Psychiatry, Yale School of Medicine, New Haven, CT 06519, USA
    Neuron 40:139-50. 2003
  2. ncbi request reprint Hallucinogen-induced UP states in the brain slice of rat prefrontal cortex: role of glutamate spillover and NR2B-NMDA receptors
    Evelyn K Lambe
    Department of Psychiatry, Yale School of Medicine, New Haven, CT 06508, USA
    Neuropsychopharmacology 31:1682-9. 2006
  3. ncbi request reprint Severe deficits in 5-HT2A -mediated neurotransmission in BDNF conditional mutant mice
    Maribel Rios
    Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Neurobiol 66:408-20. 2006
  4. pmc Serotonin receptor expression in human prefrontal cortex: balancing excitation and inhibition across postnatal development
    Evelyn K Lambe
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 6:e22799. 2011
  5. pmc Schizophrenia, hypocretin (orexin), and the thalamocortical activating system
    Evelyn K Lambe
    Department of Physiology, University of Toronto, Toronto, Canada
    Schizophr Bull 33:1284-90. 2007
  6. pmc Prefrontal cortical network activity: Opposite effects of psychedelic hallucinogens and D1/D5 dopamine receptor activation
    E K Lambe
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06508, USA
    Neuroscience 145:900-10. 2007
  7. ncbi request reprint Serotonin induces EPSCs preferentially in layer V pyramidal neurons of the frontal cortex in the rat
    E K Lambe
    Interdepartmental Neuroscience Program, Section of Neurobiology, and Departments of Psychiatry and Pharmacology, Yale University School of Medicine, New Haven, CT, USA
    Cereb Cortex 10:974-80. 2000
  8. ncbi request reprint Differential postnatal development of catecholamine and serotonin inputs to identified neurons in prefrontal cortex of rhesus monkey
    E K Lambe
    Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 20:8780-7. 2000
  9. ncbi request reprint MRI correlates of treatment response in first episode psychosis
    R B Zipursky
    Clarke Institute of Psychiatry, University of Toronto School of Medicine, Ontario, Canada
    Schizophr Res 30:81-90. 1998
  10. ncbi request reprint The role of Kv1.2-containing potassium channels in serotonin-induced glutamate release from thalamocortical terminals in rat frontal cortex
    E K Lambe
    Interdepartmental Neuroscience Program and Departments of Psychiatry and Pharmacology, Yale University School of Medicine, New Haven Connecticut 06508, USA
    J Neurosci 21:9955-63. 2001

Collaborators

  • George Aghajanian
  • Rong Jian Liu
  • S Kapur
  • Schahram Akbarian
  • MARINA PICCIOTTO
  • Craig D C Bailey
  • Nyresa C Alves
  • Nathalie M Goodfellow
  • Sameera M Kassam
  • Maribel Rios
  • R B Zipursky
  • Raad Nashmi
  • Paul J Fletcher
  • Mariella De Biasi
  • Vidita A Vaidya
  • Madhurima Benekareddy
  • Patrick M Herman
  • Jinhong Liu
  • Sarah Teillon
  • Suzanne Roffler-Tarlov
  • Rudolf Jaenisch
  • G Bean
  • D J Mikulis
  • M Beiser
  • J Zhang-Wong

Detail Information

Publications18

  1. ncbi request reprint Hypocretin (orexin) induces calcium transients in single spines postsynaptic to identified thalamocortical boutons in prefrontal slice
    Evelyn K Lambe
    Department of Psychiatry, Yale School of Medicine, New Haven, CT 06519, USA
    Neuron 40:139-50. 2003
    ..By this mechanism, the hypocretin projection to prefrontal cortex may play a larger role in prefrontal or "executive" aspects of alertness and attention than previously anticipated...
  2. ncbi request reprint Hallucinogen-induced UP states in the brain slice of rat prefrontal cortex: role of glutamate spillover and NR2B-NMDA receptors
    Evelyn K Lambe
    Department of Psychiatry, Yale School of Medicine, New Haven, CT 06508, USA
    Neuropsychopharmacology 31:1682-9. 2006
    ..Such recruitment could account for certain cognitive, affective, and sensory perturbations generated by psychedelic hallucinogens...
  3. ncbi request reprint Severe deficits in 5-HT2A -mediated neurotransmission in BDNF conditional mutant mice
    Maribel Rios
    Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Neurobiol 66:408-20. 2006
    ....
  4. pmc Serotonin receptor expression in human prefrontal cortex: balancing excitation and inhibition across postnatal development
    Evelyn K Lambe
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 6:e22799. 2011
    ..Examining and understanding the healthy balance is critical to appreciate how abnormal expression of an individual HTR may create a window of vulnerability for the emergence of psychiatric illness...
  5. pmc Schizophrenia, hypocretin (orexin), and the thalamocortical activating system
    Evelyn K Lambe
    Department of Physiology, University of Toronto, Toronto, Canada
    Schizophr Bull 33:1284-90. 2007
    ....
  6. pmc Prefrontal cortical network activity: Opposite effects of psychedelic hallucinogens and D1/D5 dopamine receptor activation
    E K Lambe
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06508, USA
    Neuroscience 145:900-10. 2007
    ..The tempering of network UP states by D1/D5 receptor activation may have implications for the proposed use of D1/D5 agonists in the treatment of schizophrenia...
  7. ncbi request reprint Serotonin induces EPSCs preferentially in layer V pyramidal neurons of the frontal cortex in the rat
    E K Lambe
    Interdepartmental Neuroscience Program, Section of Neurobiology, and Departments of Psychiatry and Pharmacology, Yale University School of Medicine, New Haven, CT, USA
    Cereb Cortex 10:974-80. 2000
    ..The specific induction of EPSCs in layer V neurons suggests that 5-HT preferentially modulates the output neurons of the frontal cortex...
  8. ncbi request reprint Differential postnatal development of catecholamine and serotonin inputs to identified neurons in prefrontal cortex of rhesus monkey
    E K Lambe
    Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 20:8780-7. 2000
    ..By contrast, 5-HT innervation of both types of neurons remains relatively constant over the age range studied...
  9. ncbi request reprint MRI correlates of treatment response in first episode psychosis
    R B Zipursky
    Clarke Institute of Psychiatry, University of Toronto School of Medicine, Ontario, Canada
    Schizophr Res 30:81-90. 1998
    ..It remains to be determined whether the degree to which particular domains of symptomatology can improve is related to the severity of structural brain pathology in specific brain regions...
  10. ncbi request reprint The role of Kv1.2-containing potassium channels in serotonin-induced glutamate release from thalamocortical terminals in rat frontal cortex
    E K Lambe
    Interdepartmental Neuroscience Program and Departments of Psychiatry and Pharmacology, Yale University School of Medicine, New Haven Connecticut 06508, USA
    J Neurosci 21:9955-63. 2001
    ..These results indicate that blockade of Kv1.2-containing potassium channels is part of the mechanism underlying 5-HT-induced glutamate release from thalamocortical terminals...
  11. ncbi request reprint Hypocretin and nicotine excite the same thalamocortical synapses in prefrontal cortex: correlation with improved attention in rat
    Evelyn K Lambe
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    J Neurosci 25:5225-9. 2005
    ..We show for the first time that hypocretin can improve attentional processes relevant to executive functions of the prefrontal cortex...
  12. ncbi request reprint Cerebral gray matter volume deficits in first episode psychosis
    R B Zipursky
    Clarke Institute of Psychiatry, Department of Psychiatry, University of Toronto School of Medicine, Ontario, Canada
    Arch Gen Psychiatry 55:540-6. 1998
    ..We hypothesized that deficits in gray matter volume would be present in patients presenting with a first episode of nonaffective psychosis...
  13. ncbi request reprint Nicotine induces glutamate release from thalamocortical terminals in prefrontal cortex
    Evelyn K Lambe
    Departments of Psychiatry and Pharmacology, Yale School of Medicine, New Haven, CT, USA
    Neuropsychopharmacology 28:216-25. 2003
    ..These findings give new insight into the mechanism by which nicotine affects excitatory neurotransmission to the output neurons of the cerebral cortex in a pathway that is critical for cognitive function and reward expectation...
  14. pmc Developmental excitation of corticothalamic neurons by nicotinic acetylcholine receptors
    Sameera M Kassam
    Departments of Physiology and Obstetrics and Gynaecology, University of Toronto, Toronto, Ontario, Canada
    J Neurosci 28:8756-64. 2008
    ..In summary, we show that layer VI corticothalamic neurons can be strongly excited during development by an unusual subtype of nicotinic receptor...
  15. pmc Layer II/III of the prefrontal cortex: Inhibition by the serotonin 5-HT1A receptor in development and stress
    Nathalie M Goodfellow
    Department of Physiology, University of Toronto, Ontario, Canada
    J Neurosci 29:10094-103. 2009
    ..These data represent the first examination of functional 5-HT(1A) receptors in layer II/III of the prefrontal cortex during normal development as well as after stress...
  16. pmc Developmental sex differences in nicotinic currents of prefrontal layer VI neurons in mice and rats
    Nyresa C Alves
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 5:e9261. 2010
    ..The present study was undertaken to investigate whether there are sex differences in the nicotinic currents in prefrontal layer VI neurons during development...
  17. pmc The nicotinic acetylcholine receptor alpha5 subunit plays a key role in attention circuitry and accuracy
    Craig D C Bailey
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    J Neurosci 30:9241-52. 2010
    ..Together, these findings demonstrate a novel and important role for the nicotinic receptor alpha5 subunit in adult brain circuitry required for attentional performance...
  18. ncbi request reprint Somatodendritic autoreceptor regulation of serotonergic neurons: dependence on L-tryptophan and tryptophan hydroxylase-activating kinases
    Rong Jian Liu
    Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA
    Eur J Neurosci 21:945-58. 2005
    ..Increased calcium influx at higher firing rates, by activating tryptophan hydroxylase via CaMKII and PKA, can work together with tryptophan to enhance negative feedback control of the output of the serotonergic system...