R W Lam

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. ncbi request reprint Effects of light therapy on suicidal ideation in patients with winter depression
    R W Lam
    Department of Psychiatry, University of British Columbia, and the University of British Columbia Hospital, Vancouver, Canada
    J Clin Psychiatry 61:30-2. 2000
  2. ncbi request reprint Seasonal depression: the dual vulnerability hypothesis revisited
    R W Lam
    Division of Mood Disorders, Department of Psychiatry, University of British Columbia Hospital, Vancouver Hospital and Health Sciences Centre, 2255 Wesbrook Mall, BC, Canada V6T 2A1
    J Affect Disord 63:123-32. 2001
  3. ncbi request reprint Effects of alpha-methyl-para-tyrosine-induced catecholamine depletion in patients with seasonal affective disorder in summer remission
    R W Lam
    Division of Mood Disorders, Department of Psychiatry, University of British Columbia, and UBC Hospital, Vancouver Hospital and Health Sciences Centre, Vancouver, B C, Canada
    Neuropsychopharmacology 25:S97-101. 2001
  4. ncbi request reprint An open trial of light therapy for women with seasonal affective disorder and comorbid bulimia nervosa
    R W Lam
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    J Clin Psychiatry 62:164-8. 2001
  5. ncbi request reprint A controlled study of light therapy in women with late luteal phase dysphoric disorder
    R W Lam
    Department of Psychiatry, University of British Columbia, Vancouver Hospital and Health Sciences Centre, Canada
    Psychiatry Res 86:185-92. 1999
  6. pmc Pathophysiology of seasonal affective disorder: a review
    R W Lam
    Division of Mood Disorders, Department of Psychiatry, University of British Columbia, UBC Hospital, Vancouver, BC
    J Psychiatry Neurosci 25:469-80. 2000
  7. ncbi request reprint Decrease in brain serotonin 2 receptor binding in patients with major depression following desipramine treatment: a positron emission tomography study with fluorine-18-labeled setoperone
    L N Yatham
    Division of Mood Disorders, The University of British Columbia, Vancouver, Canada
    Arch Gen Psychiatry 56:705-11. 1999
  8. ncbi request reprint Brain serotonin2 receptors in major depression: a positron emission tomography study
    L N Yatham
    Mood Disorders Clinical Research Unit, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 2A1
    Arch Gen Psychiatry 57:850-8. 2000
  9. ncbi request reprint Childhood inattention and dysphoria and adult obesity associated with the dopamine D4 receptor gene in overeating women with seasonal affective disorder
    R D Levitan
    Department of Psychiatry, Centre for Addiction and Mental Health, University of Toronto, Canada
    Neuropsychopharmacology 29:179-86. 2004
  10. ncbi request reprint L-tryptophan augmentation of light therapy in patients with seasonal affective disorder
    R W Lam
    Department of Psychiatry, University of British Columbia, Vancouver
    Can J Psychiatry 42:303-6. 1997

Detail Information

Publications24

  1. ncbi request reprint Effects of light therapy on suicidal ideation in patients with winter depression
    R W Lam
    Department of Psychiatry, University of British Columbia, and the University of British Columbia Hospital, Vancouver, Canada
    J Clin Psychiatry 61:30-2. 2000
    ..This retrospective study sought to determine the effects of light therapy on suicidal ideation in patients with SAD...
  2. ncbi request reprint Seasonal depression: the dual vulnerability hypothesis revisited
    R W Lam
    Division of Mood Disorders, Department of Psychiatry, University of British Columbia Hospital, Vancouver Hospital and Health Sciences Centre, 2255 Wesbrook Mall, BC, Canada V6T 2A1
    J Affect Disord 63:123-32. 2001
    ..In this study, we compare the clinical characteristics of these three seasonal groups and their response to light therapy...
  3. ncbi request reprint Effects of alpha-methyl-para-tyrosine-induced catecholamine depletion in patients with seasonal affective disorder in summer remission
    R W Lam
    Division of Mood Disorders, Department of Psychiatry, University of British Columbia, and UBC Hospital, Vancouver Hospital and Health Sciences Centre, Vancouver, B C, Canada
    Neuropsychopharmacology 25:S97-101. 2001
    ..AMPT-induced depressive relapse may be a trait marker for SAD, and/or brain catecholamines may play a direct role in the pathogenesis of SAD...
  4. ncbi request reprint An open trial of light therapy for women with seasonal affective disorder and comorbid bulimia nervosa
    R W Lam
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    J Clin Psychiatry 62:164-8. 2001
    ..Controlled studies of light therapy in SAD and in bulimia nervosa have shown beneficial effects on mood and binge/purge symptoms. We explored the clinical use of light therapy in women with SAD who also had comorbid bulimia nervosa...
  5. ncbi request reprint A controlled study of light therapy in women with late luteal phase dysphoric disorder
    R W Lam
    Department of Psychiatry, University of British Columbia, Vancouver Hospital and Health Sciences Centre, Canada
    Psychiatry Res 86:185-92. 1999
    ..These results suggest that bright light therapy is an effective treatment for LLPDD...
  6. pmc Pathophysiology of seasonal affective disorder: a review
    R W Lam
    Division of Mood Disorders, Department of Psychiatry, University of British Columbia, UBC Hospital, Vancouver, BC
    J Psychiatry Neurosci 25:469-80. 2000
    ..Recent progress in defining the molecular mechanisms of the human circadian clock and retinal phototransduction of light will provide important new directions for future studies of the etiology and pathophysiology of SAD...
  7. ncbi request reprint Decrease in brain serotonin 2 receptor binding in patients with major depression following desipramine treatment: a positron emission tomography study with fluorine-18-labeled setoperone
    L N Yatham
    Division of Mood Disorders, The University of British Columbia, Vancouver, Canada
    Arch Gen Psychiatry 56:705-11. 1999
    ..Our purpose, therefore, was to assess the effects of treatment with desipramine hydrochloride on brain 5-HT2 receptors in depressed patients using positron emission tomography (PET) and fluorine-18 (18F)-labeled setoperone...
  8. ncbi request reprint Brain serotonin2 receptors in major depression: a positron emission tomography study
    L N Yatham
    Mood Disorders Clinical Research Unit, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 2A1
    Arch Gen Psychiatry 57:850-8. 2000
    ..1 +/- 9.5 years; range, 22-60 years) and 20 healthy controls similar in age (37.2 +/- 12.6 years; range, 19-59 years) using positron emission tomography and setoperone labeled with fluorine 18 ([(18)F]setoperone)...
  9. ncbi request reprint Childhood inattention and dysphoria and adult obesity associated with the dopamine D4 receptor gene in overeating women with seasonal affective disorder
    R D Levitan
    Department of Psychiatry, Centre for Addiction and Mental Health, University of Toronto, Canada
    Neuropsychopharmacology 29:179-86. 2004
    ....
  10. ncbi request reprint L-tryptophan augmentation of light therapy in patients with seasonal affective disorder
    R W Lam
    Department of Psychiatry, University of British Columbia, Vancouver
    Can J Psychiatry 42:303-6. 1997
    ..Given the evidence for serotonergic dysregulation in SAD, we examined the possible role of l-tryptophan as an augmentation strategy for nonresponders and partial responders to light therapy...
  11. doi request reprint Childhood maltreatment and corpus callosum volume in recently diagnosed patients with bipolar I disorder: data from the Systematic Treatment Optimization Program for Early Mania (STOP-EM)
    J Bücker
    Department of Psychiatry, University of British Columbia, Vancouver, Canada Bipolar Disorder Program and Laboratory of Molecular Psychiatry, National Institute for Translational Medicine, INCT TM, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    J Psychiatr Res 48:65-72. 2014
    ..It might mean there may be two sources of CC volume reduction in these patients: the reduction due to trauma, and the further reduction due to the illness...
  12. ncbi request reprint Gender differences in the heritability of seasonal mood change
    K L Jang
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Psychiatry Res 70:145-54. 1997
    ..5%) and females (median, 30.5%). For both sexes, weight changes were not heritable. Sex-by-genotype analyses suggested that the genetic factors influencing female seasonality may not be the same as those influencing male seasonality...
  13. ncbi request reprint A PET study of brain 5-HT2 receptors and their correlation with platelet 5-HT2 receptors in healthy humans
    L N Yatham
    Division of Mood Disorders Clinical Research Unit, The University of British Columbia, Vancouver, Canada
    Psychopharmacology (Berl) 151:424-7. 2000
    ..Platelets share many properties with brain serotonergic neurons such as active 5-hydroxytryptamine (5-HT) transport, 5-HT2 receptors, and mitochondrial monoamine oxidase...
  14. ncbi request reprint A community-based clinic survey of antidepressant use in persons with schizophrenia
    R W Lam
    Department of Psychiatry, University of British Columbia, Vancouver
    Can J Psychiatry 43:513-6. 1998
    ..To determine the rates of antidepressant and antipsychotic use in the treatment of schizophrenia...
  15. ncbi request reprint Hypothermic, ACTH, and cortisol responses to ipsapirone in patients with mania and healthy controls
    L N Yatham
    Department of Psychiatry, The University of British Columbia, Vancouver, Canada
    J Affect Disord 54:295-301. 1999
    ....
  16. ncbi request reprint Clinical predictors of short-term outcome in electroconvulsive therapy
    R W Lam
    Department of Psychiatry, University of British Columbia, Vancouver
    Can J Psychiatry 44:158-63. 1999
    ..This study examined ECT use in a university teaching hospital to determine predictors of short-term ECT outcome...
  17. ncbi request reprint Effects of rapid tryptophan depletion on brain 5-HT(2) receptors: a PET study
    L N Yatham
    Division of Mood Disorders, The University of British Columbia, Canada
    Br J Psychiatry 178:448-53. 2001
    ..The mechanism by which rapid tryptophan depletion (RTD) paradigm induces depressive relapse in recently remitted patients with depression is unknown...
  18. doi request reprint The impact of childhood trauma on cognitive functioning in patients recently recovered from a first manic episode: data from the Systematic Treatment Optimization Program for Early Mania (STOP-EM)
    J Bücker
    Department of Psychiatry, University of British Columbia, Vancouver, Canada BC V6T2A1
    J Affect Disord 148:424-30. 2013
    ..In this study, we investigated the impact of childhood trauma on specific cognitive dysfunction in patients who recently recovered from their first episode of mania...
  19. ncbi request reprint Seasonal mood change and personality: an investigation of genetic co-morbidity
    K L Jang
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Psychiatry Res 78:1-7. 1998
    ..19. These results provide evidence that the observed correlations between these seasonality and personality dimensions are attributable to common genetic factors and that environmental influences are domain specific...
  20. ncbi request reprint Comparative efficacy of typical and atypical antipsychotics as add-on therapy to mood stabilizers in the treatment of acute mania
    D S Miller
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    J Clin Psychiatry 62:975-80. 2001
    ..atypical antipsychotics are an excellent choice as add-on therapy to mood stabilizers for the treatment of patients with mania...
  21. ncbi request reprint The influence of baseline severity on efficacy of escitalopram and citalopram in the treatment of major depressive disorder: an extended analysis
    R W Lam
    University of British Columbia, Vancouver, British Columbia, Canada
    Pharmacopsychiatry 39:180-4. 2006
    ..To determine the differences between escitalopram and citalopram in the treatment of patients with major depressive disorder across a range of baseline severity of depression using trend analysis...
  22. doi request reprint Addressing circadian rhythm disturbances in depressed patients
    R W Lam
    Division of Clinical Neuroscience, Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    J Psychopharmacol 22:13-8. 2008
    ..These positive features provide a novel approach to the treatment of depression and the attainment of high-quality remission in MDD...
  23. doi request reprint Relationship between cognitive functioning and 6-month clinical and functional outcome in patients with first manic episode bipolar I disorder
    I J Torres
    Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    Psychol Med 41:971-82. 2011
    ..The purpose of this study was to evaluate the impact of cognitive functioning on longitudinal 6-month functional and clinical outcome in recently diagnosed clinically stable patients with bipolar disorder...
  24. ncbi request reprint Polymorphism of the serotonin-2A receptor gene (HTR2A) associated with childhood attention deficit hyperactivity disorder (ADHD) in adult women with seasonal affective disorder
    R D Levitan
    Centre for Addiction and Mental Health, University of Toronto, Department of Psychiatry, Toronto, Ontario, Canada
    J Affect Disord 71:229-33. 2002
    ..The current study investigated whether variation in HTR2A was associated with symptoms of childhood ADHD in adult women with SAD...