R W Lam

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. pmc A controlled trial of the Litebook light-emitting diode (LED) light therapy device for treatment of Seasonal Affective Disorder (SAD)
    Paul H Desan
    Department of Psychiatry, Yale University, New Haven, CT 06520 8068, USA
    BMC Psychiatry 7:38. 2007
  2. doi request reprint The prevalence and impact of depression in self-referred clients attending an employee assistance program
    Raymond W Lam
    Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada
    J Occup Environ Med 54:1395-9. 2012
  3. ncbi request reprint Onset, time course and trajectories of improvement with antidepressants
    Raymond W Lam
    Department of Psychiatry, University of British Columbia, Mood Disorders Centre of Excellence, UBC Hospital, 2255 Wesbrook Mall, Vancouver, BC, Canada V6T 2A1
    Eur Neuropsychopharmacol 22:S492-8. 2012
  4. pmc Quality of life in bipolar disorder: a review of the literature
    Erin E Michalak
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Health Qual Life Outcomes 3:72. 2005
  5. pmc Is remission of depressive symptoms in primary care a realistic goal? A meta-analysis
    Marliese Y Dawson
    Division of Clinical Neuroscience, Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, Canada V6T 2A1
    BMC Fam Pract 5:19. 2004
  6. doi request reprint Canadian Network for Mood and Anxiety Treatments (CANMAT) clinical guidelines for the management of major depressive disorder in adults. III. Pharmacotherapy
    Raymond W Lam
    University of British Columbia, Canada
    J Affect Disord 117:S26-43. 2009
  7. pmc A new clinical rating scale for work absence and productivity: validation in patients with major depressive disorder
    Raymond W Lam
    Department of Psychiatry, University of BC, Mood Disorders Centre, UBC Hospital, Vancouver, Canada
    BMC Psychiatry 9:78. 2009
  8. ncbi request reprint The influence of baseline severity on efficacy of escitalopram and citalopram in the treatment of major depressive disorder: an extended analysis
    R W Lam
    University of British Columbia, Vancouver, British Columbia, Canada
    Pharmacopsychiatry 39:180-4. 2006
  9. ncbi request reprint Efficacy, effectiveness and efficiency of escitalopram in the treatment of major depressive and anxiety disorders
    Raymond W Lam
    Professor of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, V6T 2A1, Canada
    Expert Rev Pharmacoecon Outcomes Res 7:559-76. 2007
  10. ncbi request reprint Repetitive transcranial magnetic stimulation for treatment-resistant depression: a systematic review and metaanalysis
    Raymond W Lam
    Division of Clinical Neuroscience, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia
    Can J Psychiatry 53:621-31. 2008

Detail Information

Publications83

  1. pmc A controlled trial of the Litebook light-emitting diode (LED) light therapy device for treatment of Seasonal Affective Disorder (SAD)
    Paul H Desan
    Department of Psychiatry, Yale University, New Haven, CT 06520 8068, USA
    BMC Psychiatry 7:38. 2007
    ..Light treatment devices using efficient light-emitting diodes (LEDs) whose output is relatively concentrated in short wavelengths may enable a more convenient effective therapy for Seasonal Affective Disorder (SAD)...
  2. doi request reprint The prevalence and impact of depression in self-referred clients attending an employee assistance program
    Raymond W Lam
    Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada
    J Occup Environ Med 54:1395-9. 2012
    ..To determine the prevalence and characteristics of clients with depression attending an employee assistance program (EAP)...
  3. ncbi request reprint Onset, time course and trajectories of improvement with antidepressants
    Raymond W Lam
    Department of Psychiatry, University of British Columbia, Mood Disorders Centre of Excellence, UBC Hospital, 2255 Wesbrook Mall, Vancouver, BC, Canada V6T 2A1
    Eur Neuropsychopharmacol 22:S492-8. 2012
    ..A lack of improvement (defined as ≤20% reduction from baseline in scores on a depression rating scale) at 2-3 weeks after initiation of an antidepressant should prompt the clinician to consider a change in management...
  4. pmc Quality of life in bipolar disorder: a review of the literature
    Erin E Michalak
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Health Qual Life Outcomes 3:72. 2005
    ..We identified several important avenues for future research, including a need for more assessment of QoL in hypo/manic patients, more longitudinal research and the development of a disease-specific measure of QoL for patients with BD...
  5. pmc Is remission of depressive symptoms in primary care a realistic goal? A meta-analysis
    Marliese Y Dawson
    Division of Clinical Neuroscience, Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, Canada V6T 2A1
    BMC Fam Pract 5:19. 2004
    ..The goal of this study was to determine remission rates obtained in RCTs of treatment interventions for Major Depressive Disorder (MDD) conducted in primary care settings...
  6. doi request reprint Canadian Network for Mood and Anxiety Treatments (CANMAT) clinical guidelines for the management of major depressive disorder in adults. III. Pharmacotherapy
    Raymond W Lam
    University of British Columbia, Canada
    J Affect Disord 117:S26-43. 2009
    ..A revision of these guidelines was undertaken by CANMAT in 2008-2009 to reflect advances in the field...
  7. pmc A new clinical rating scale for work absence and productivity: validation in patients with major depressive disorder
    Raymond W Lam
    Department of Psychiatry, University of BC, Mood Disorders Centre, UBC Hospital, Vancouver, Canada
    BMC Psychiatry 9:78. 2009
    ..This study seeks to validate the Lam Employment Absence and Productivity Scale (LEAPS), a 10-item self-report questionnaire that takes 3-5 minutes to complete...
  8. ncbi request reprint The influence of baseline severity on efficacy of escitalopram and citalopram in the treatment of major depressive disorder: an extended analysis
    R W Lam
    University of British Columbia, Vancouver, British Columbia, Canada
    Pharmacopsychiatry 39:180-4. 2006
    ..To determine the differences between escitalopram and citalopram in the treatment of patients with major depressive disorder across a range of baseline severity of depression using trend analysis...
  9. ncbi request reprint Efficacy, effectiveness and efficiency of escitalopram in the treatment of major depressive and anxiety disorders
    Raymond W Lam
    Professor of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, V6T 2A1, Canada
    Expert Rev Pharmacoecon Outcomes Res 7:559-76. 2007
    ..Escitalopram has a prominent role in the treatment of major depressive disorder and anxiety disorders, and may also prove to be important in the treatment of mixed depressive anxiety disorder...
  10. ncbi request reprint Repetitive transcranial magnetic stimulation for treatment-resistant depression: a systematic review and metaanalysis
    Raymond W Lam
    Division of Clinical Neuroscience, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia
    Can J Psychiatry 53:621-31. 2008
    ..None have specifically examined outcomes in patients with treatment-resistant depression (TRD)...
  11. ncbi request reprint The Can-SAD study: a randomized controlled trial of the effectiveness of light therapy and fluoxetine in patients with winter seasonal affective disorder
    Raymond W Lam
    Mood Disorders Centre, UBC Hospital, 2255 Wesbrook Mall, Vancouver, BC V6T 2A1
    Am J Psychiatry 163:805-12. 2006
    ..This study compared the effectiveness of light therapy and an antidepressant within a single trial...
  12. doi request reprint Escitalopram and duloxetine in the treatment of major depressive disorder: a pooled analysis of two trials
    Raymond W Lam
    Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    Int Clin Psychopharmacol 23:181-7. 2008
    ..This pooled analysis shows that over an 8-week treatment period, escitalopram (10-20 mg/day) is superior in both effectiveness and tolerability compared with duloxetine (60 mg/day)...
  13. doi request reprint Escitalopram versus serotonin noradrenaline reuptake inhibitors as second step treatment for patients with major depressive disorder: a pooled analysis
    Raymond W Lam
    Department of Psychiatry, University of British Columbia, Mood Disorders Centre, UBC Hospital, Vancouver, Canada
    Int Clin Psychopharmacol 25:199-203. 2010
    ..These results should be confirmed in prospective randomized clinical trials...
  14. ncbi request reprint Citalopram and bupropion-SR: combining versus switching in patients with treatment-resistant depression
    Raymond W Lam
    Division of Clinical Neuroscience, Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, V6T 2A1 Canada
    J Clin Psychiatry 65:337-40. 2004
    ..In this study, we compared the effects of combining citalopram and bupropion-SR versus switching to the other monotherapy in treatment-resistant depression...
  15. ncbi request reprint Evidence-based strategies for achieving and sustaining full remission in depression: focus on metaanalyses
    Raymond W Lam
    Department of Psychiatry, University of British Columbia, Vancouver
    Can J Psychiatry 49:17S-26S. 2004
    ..Randomized controlled clinical trials conducted in the last 5 years provide very good evidence to show that achieving and sustaining the fully remitted state is an attainable goal in the management of patients with depression...
  16. ncbi request reprint High-quality remission: potential benefits of the melatonergic approach for patients with major depressive disorder
    Raymond W Lam
    Division of Clinical Neuroscience, Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    Int Clin Psychopharmacol 22:S21-5. 2007
    ....
  17. ncbi request reprint Does neuroimmune dysfunction mediate seasonal mood changes in winter depression?
    Raymond W Lam
    Division of Clinical Neuroscience, Department of Psychiatry, University of British Columbia UBC, 2255 Wesbrook Mall, Vancouver, BC, Canada V6T 2A1
    Med Hypotheses 63:567-73. 2004
    ..The etiology of winter depression (seasonal affective disorder, or SAD) is not known, but a number of studies have provided support for both photoperiod and neurotransmitter hypotheses...
  18. ncbi request reprint Combining antidepressants for treatment-resistant depression: a review
    Raymond W Lam
    Division of Mood Disorders, Department of Psychiatry, University of British Columbia, UBC Hospital, Vancouver, British Columbia, Canada
    J Clin Psychiatry 63:685-93. 2002
    ..This review critically evaluates the evidence for efficacy of combining antidepressants...
  19. doi request reprint The importance of early symptom relief in antidepressant treatment: focus on agomelatine
    Raymond W Lam
    Department of Psychiatry, University of British Columbia, UBC Hospital, Vancouver, BC, Canada
    J Psychopharmacol 24:27-30. 2010
    ..These properties suggest that agomelatine can be considered a first-line treatment for patients with major depression...
  20. ncbi request reprint Telephone-administered cognitive-behavioral therapy for clients with depressive symptoms in an employee assistance program: a pilot study
    Raymond W Lam
    Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    Ann Clin Psychiatry 23:11-6. 2011
    ..To assess the clinical and work productivity effects of a brief intervention using telephone-administered cognitive-behavioral therapy (CBT) for clients with depressive symptoms attending an employee assistance program (EAP)...
  21. doi request reprint Clinical effectiveness: the importance of psychosocial functioning outcomes
    Raymond W Lam
    Department of Psychiatry, University of BC, Mood Disorders Centre, UBC Hospital, Vancouver, BC, Canada
    J Affect Disord 132:S9-S13. 2011
    ..However, clinical trials for depression have primarily focused on reduction in symptoms, as measured by symptom severity scales such as the HDRS and MADRS or by standard definitions of response and remission...
  22. doi request reprint Addressing circadian rhythm disturbances in depressed patients
    R W Lam
    Division of Clinical Neuroscience, Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    J Psychopharmacol 22:13-8. 2008
    ..These positive features provide a novel approach to the treatment of depression and the attainment of high-quality remission in MDD...
  23. ncbi request reprint Using metaanalysis to evaluate evidence: practical tips and traps
    Raymond W Lam
    Division of Clinical Neuroscience, Department of Psychiatry, University of British Columbia, Vancouver
    Can J Psychiatry 50:167-74. 2005
    ..This paper focuses on basic principles and terms used in metaanalysis, so that clinicians can appropriately evaluate and use their results to guide treatment decisions...
  24. ncbi request reprint Decrease in brain serotonin 2 receptor binding in patients with major depression following desipramine treatment: a positron emission tomography study with fluorine-18-labeled setoperone
    L N Yatham
    Division of Mood Disorders, The University of British Columbia, Vancouver, Canada
    Arch Gen Psychiatry 56:705-11. 1999
    ..Our purpose, therefore, was to assess the effects of treatment with desipramine hydrochloride on brain 5-HT2 receptors in depressed patients using positron emission tomography (PET) and fluorine-18 (18F)-labeled setoperone...
  25. ncbi request reprint Brain serotonin2 receptors in major depression: a positron emission tomography study
    L N Yatham
    Mood Disorders Clinical Research Unit, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 2A1
    Arch Gen Psychiatry 57:850-8. 2000
    ..1 +/- 9.5 years; range, 22-60 years) and 20 healthy controls similar in age (37.2 +/- 12.6 years; range, 19-59 years) using positron emission tomography and setoperone labeled with fluorine 18 ([(18)F]setoperone)...
  26. ncbi request reprint L-tryptophan augmentation of light therapy in patients with seasonal affective disorder
    R W Lam
    Department of Psychiatry, University of British Columbia, Vancouver
    Can J Psychiatry 42:303-6. 1997
    ..Given the evidence for serotonergic dysregulation in SAD, we examined the possible role of l-tryptophan as an augmentation strategy for nonresponders and partial responders to light therapy...
  27. ncbi request reprint Seasonal depression: the dual vulnerability hypothesis revisited
    R W Lam
    Division of Mood Disorders, Department of Psychiatry, University of British Columbia Hospital, Vancouver Hospital and Health Sciences Centre, 2255 Wesbrook Mall, BC, Canada V6T 2A1
    J Affect Disord 63:123-32. 2001
    ..In this study, we compare the clinical characteristics of these three seasonal groups and their response to light therapy...
  28. ncbi request reprint An open trial of light therapy for women with seasonal affective disorder and comorbid bulimia nervosa
    R W Lam
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    J Clin Psychiatry 62:164-8. 2001
    ..Controlled studies of light therapy in SAD and in bulimia nervosa have shown beneficial effects on mood and binge/purge symptoms. We explored the clinical use of light therapy in women with SAD who also had comorbid bulimia nervosa...
  29. ncbi request reprint Effects of light therapy on suicidal ideation in patients with winter depression
    R W Lam
    Department of Psychiatry, University of British Columbia, and the University of British Columbia Hospital, Vancouver, Canada
    J Clin Psychiatry 61:30-2. 2000
    ..This retrospective study sought to determine the effects of light therapy on suicidal ideation in patients with SAD...
  30. ncbi request reprint Clinical predictors of short-term outcome in electroconvulsive therapy
    R W Lam
    Department of Psychiatry, University of British Columbia, Vancouver
    Can J Psychiatry 44:158-63. 1999
    ..This study examined ECT use in a university teaching hospital to determine predictors of short-term ECT outcome...
  31. ncbi request reprint Gender differences in the heritability of seasonal mood change
    K L Jang
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Psychiatry Res 70:145-54. 1997
    ..5%) and females (median, 30.5%). For both sexes, weight changes were not heritable. Sex-by-genotype analyses suggested that the genetic factors influencing female seasonality may not be the same as those influencing male seasonality...
  32. ncbi request reprint A community-based clinic survey of antidepressant use in persons with schizophrenia
    R W Lam
    Department of Psychiatry, University of British Columbia, Vancouver
    Can J Psychiatry 43:513-6. 1998
    ..To determine the rates of antidepressant and antipsychotic use in the treatment of schizophrenia...
  33. ncbi request reprint A PET study of brain 5-HT2 receptors and their correlation with platelet 5-HT2 receptors in healthy humans
    L N Yatham
    Division of Mood Disorders Clinical Research Unit, The University of British Columbia, Vancouver, Canada
    Psychopharmacology (Berl) 151:424-7. 2000
    ..Platelets share many properties with brain serotonergic neurons such as active 5-hydroxytryptamine (5-HT) transport, 5-HT2 receptors, and mitochondrial monoamine oxidase...
  34. ncbi request reprint A controlled study of light therapy in women with late luteal phase dysphoric disorder
    R W Lam
    Department of Psychiatry, University of British Columbia, Vancouver Hospital and Health Sciences Centre, Canada
    Psychiatry Res 86:185-92. 1999
    ..These results suggest that bright light therapy is an effective treatment for LLPDD...
  35. ncbi request reprint Hypothermic, ACTH, and cortisol responses to ipsapirone in patients with mania and healthy controls
    L N Yatham
    Department of Psychiatry, The University of British Columbia, Vancouver, Canada
    J Affect Disord 54:295-301. 1999
    ....
  36. ncbi request reprint Personality and seasonal affective disorder: results from the CAN-SAD study
    Murray W Enns
    Department of Psychiatry, University of Manitoba, Canada
    J Affect Disord 93:35-42. 2006
    ..The present study investigated the relationship between the five-factor model of personality (neuroticism, extraversion, openness, agreeableness, conscientiousness) and SAD...
  37. ncbi request reprint Effects of alpha-methyl-para-tyrosine-induced catecholamine depletion in patients with seasonal affective disorder in summer remission
    R W Lam
    Division of Mood Disorders, Department of Psychiatry, University of British Columbia, and UBC Hospital, Vancouver Hospital and Health Sciences Centre, Vancouver, B C, Canada
    Neuropsychopharmacology 25:S97-101. 2001
    ..AMPT-induced depressive relapse may be a trait marker for SAD, and/or brain catecholamines may play a direct role in the pathogenesis of SAD...
  38. ncbi request reprint Quality of life as an outcome indicator in patients with seasonal affective disorder: results from the Can-SAD study
    Erin E Michalak
    Division of Clinical Neuroscience, Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Psychol Med 37:727-36. 2007
    ..We report here on results from the Can-SAD trial, which assessed the impact of treatment with either antidepressant medication or light therapy upon QoL in patients diagnosed with SAD...
  39. ncbi request reprint Breaking the myths: new treatment approaches for chronic depression
    Erin E Michalak
    Division of Mood Disorders, Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC V6T 2A1
    Can J Psychiatry 47:635-43. 2002
    ..In the past, chronic depression has been thought to be treatment-resistant, and evidence suggests that it is currently underdiagnosed, misdiagnosed, and suboptimally treated...
  40. ncbi request reprint Seasonal mood change and personality: an investigation of genetic co-morbidity
    K L Jang
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Psychiatry Res 78:1-7. 1998
    ..19. These results provide evidence that the observed correlations between these seasonality and personality dimensions are attributable to common genetic factors and that environmental influences are domain specific...
  41. doi request reprint The impact of childhood trauma on cognitive functioning in patients recently recovered from a first manic episode: data from the Systematic Treatment Optimization Program for Early Mania (STOP-EM)
    J Bücker
    Department of Psychiatry, University of British Columbia, Vancouver, Canada BC V6T2A1
    J Affect Disord 148:424-30. 2013
    ..In this study, we investigated the impact of childhood trauma on specific cognitive dysfunction in patients who recently recovered from their first episode of mania...
  42. doi request reprint Relationship between cognitive functioning and 6-month clinical and functional outcome in patients with first manic episode bipolar I disorder
    I J Torres
    Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    Psychol Med 41:971-82. 2011
    ..The purpose of this study was to evaluate the impact of cognitive functioning on longitudinal 6-month functional and clinical outcome in recently diagnosed clinically stable patients with bipolar disorder...
  43. pmc Pathophysiology of seasonal affective disorder: a review
    R W Lam
    Division of Mood Disorders, Department of Psychiatry, University of British Columbia, UBC Hospital, Vancouver, BC
    J Psychiatry Neurosci 25:469-80. 2000
    ..Recent progress in defining the molecular mechanisms of the human circadian clock and retinal phototransduction of light will provide important new directions for future studies of the etiology and pathophysiology of SAD...
  44. ncbi request reprint Effects of rapid tryptophan depletion on brain 5-HT(2) receptors: a PET study
    L N Yatham
    Division of Mood Disorders, The University of British Columbia, Canada
    Br J Psychiatry 178:448-53. 2001
    ..The mechanism by which rapid tryptophan depletion (RTD) paradigm induces depressive relapse in recently remitted patients with depression is unknown...
  45. pmc Mirtazapine for treatment-resistant depression: a preliminary report
    Dante D C Wan
    Division of Mood Disorders, Department of Psychiatry, University of British Columbia and UBC Hospital, Vancouver, BC
    J Psychiatry Neurosci 28:55-9. 2003
    ..To describe the effectiveness and tolerability of mirtazapine, a noradrenergic and specific serotonergic antidepressant, in the open-label treatment of patients with depression who were resistant to other antidepressant agents...
  46. ncbi request reprint Sleep disturbances and depression: a challenge for antidepressants
    Raymond W Lam
    Division of Clinical Neuroscience, Department of Psychiatry, University of British Columbia UBC and Mood Disorders Centre of Excellence, UBC Hospital, Vancouver, Canada
    Int Clin Psychopharmacol 21:S25-9. 2006
    ..It also describes a novel antidepressant, agomelatine, which improves symptoms of depression and rapidly relieves sleep complaints without sedative effects...
  47. ncbi request reprint Course and outcome after the first manic episode in patients with bipolar disorder: prospective 12-month data from the Systematic Treatment Optimization Program For Early Mania project
    Lakshmi N Yatham
    Mood Disorders Program, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia V6T 2A1
    Can J Psychiatry 54:105-12. 2009
    ..To describe clinical characteristics, course, and outcome during a 1-year period after the first manic episode in patients with bipolar disorder (BD)...
  48. ncbi request reprint Treatment of seasonal affective disorder: unipolar versus bipolar differences
    Chang Ho Sohn
    Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, Canada V6T 2A1
    Curr Psychiatry Rep 6:478-85. 2004
    ..Chronobiological treatments such as bright light therapy may be combined with pharmacotherapy to enhance therapeutic effects, reduce adverse side effects, and optimize treatment in patients with seasonal and nonseasonal bipolar disorder...
  49. ncbi request reprint Generic and health-related quality of life in patients with seasonal and nonseasonal depression
    Erin E Michalak
    Division of Clinical Neuroscience, Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, Canada V6T 2A1
    Psychiatry Res 128:245-51. 2004
    ..Future research is required to determine whether perceived QoL is improved by treatment interventions for seasonal depression such as light therapy or antidepressant medication...
  50. ncbi request reprint Hard times and good friends: negative life events and social support in patients with seasonal and nonseasonal depression
    Erin E Michalak
    Department of Psychiatry, University of British Columbia UBC Hospital, VCHA, Vancouver, British Columbia
    Can J Psychiatry 49:408-11. 2004
    ..This study aimed to compare baseline levels of negative life events (NLEs) and perceived social support (SS) in patients with seasonal and nonseasonal depression...
  51. ncbi request reprint Comparative efficacy of typical and atypical antipsychotics as add-on therapy to mood stabilizers in the treatment of acute mania
    D S Miller
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    J Clin Psychiatry 62:975-80. 2001
    ..atypical antipsychotics are an excellent choice as add-on therapy to mood stabilizers for the treatment of patients with mania...
  52. ncbi request reprint Antidepressant-associated mood elevations in bipolar II disorder compared with bipolar I disorder and major depressive disorder: a systematic review and meta-analysis
    David J Bond
    Research and International Affairs, Mood Disorders Centre, Department of Psychiatry, University of British Columbia, Room 2C7, 2255 Wesbrook Mall, Vancouver, BC V6T 2A1 Canada
    J Clin Psychiatry 69:1589-601. 2008
    ..The risk of antidepressant-associated mood elevations (AAME) in bipolar II disorder relative to bipolar I disorder and MDD is unknown...
  53. pmc A season-of-birth/DRD4 interaction predicts maximal body mass index in women with bulimia nervosa
    Robert D Levitan
    Mood and Anxiety Division, Department of Psychiatry, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada
    Neuropsychopharmacology 35:1729-33. 2010
    ..9 vs 8.8%, respectively, p=0.008). These data offer further evidence that season of birth interacts with the 7R allele of DRD4 to influence body weight regulation in female overeating populations...
  54. ncbi request reprint A magnetic resonance imaging study of mood stabilizer- and neuroleptic-naïve first-episode mania
    Lakshmi N Yatham
    Division of Mood Disorders, University of British Columbia, Vancouver, BC, Canada
    Bipolar Disord 9:693-7. 2007
    ..Studies in first-episode (FE) manic patients have the potential to provide answers to these questions...
  55. ncbi request reprint A comparison of open treatment of seasonal major and minor depression with light therapy
    Anthony J Levitt
    Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    J Affect Disord 71:243-8. 2002
    ..The current study evaluates 3 weeks of open treatment with light therapy in SAD and subsyndromal SAD patients...
  56. ncbi request reprint Update on the biology of seasonal affective disorder
    Chang Ho Sohn
    Mood Disorders Centre, University of British Columbia Hospital, Vancouver, British Columbia, Canada
    CNS Spectr 10:635-46; quiz 1-14. 2005
    ....
  57. ncbi request reprint A pilot study of adherence with light treatment for seasonal affective disorder
    Erin E Michalak
    Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall Vancouver, BC, Canada V6T 2A1
    Psychiatry Res 149:315-20. 2007
    ..Future research studies should routinely measure and evaluate adherence with light therapy and evidence-based techniques for maximising treatment adherence should be incorporated into routine clinical practice...
  58. ncbi request reprint The dopamine-4 receptor gene associated with binge eating and weight gain in women with seasonal affective disorder: an evolutionary perspective
    Robert D Levitan
    Mood and Anxiety Division, Centre for Addiction and Mental Health, University of Toronto, Department of Psychiatry, 250 College Street, Room 1126, Toronto, Ontario M5T 1R8, Canada
    Biol Psychiatry 56:665-9. 2004
    ..In this study, we examined whether binge eating behavior mediated this putative association...
  59. ncbi request reprint Bipolar disorder and quality of life: a patient-centered perspective
    Erin E Michalak
    Division of Mood Disorders, Department of Psychiatry, University of British Columbia, Vancouver, BC V6T 2A1, Canada
    Qual Life Res 15:25-37. 2006
    ..We report here on a series of in-depth qualitative interviews we conducted as part of the item generation phase for a disease-specific scale to assess QoL in BD...
  60. pmc Antidepressant effects of exercise: evidence for an adult-neurogenesis hypothesis?
    Carl Ernst
    Neuroscience Program, UBC Hospital, University of British Columbia, Vancouver, BC
    J Psychiatry Neurosci 31:84-92. 2006
    ..We conclude that there is evidence to support the hypothesis that exercise alleviates MDD and that several mechanisms exist that could mediate this effect through adult neurogenesis...
  61. ncbi request reprint Quality of life in patients with seasonal affective disorder: summer vs winter scores
    Erin E Michalak
    Department of Psychiatry, University of British Columbia, Vancouver
    Can J Psychiatry 50:292-5. 2005
    ..To compare perceived quality of life (QoL) in patients diagnosed with seasonal affective disorder (SAD) during the winter and summer months...
  62. ncbi request reprint A birth-season/DRD4 gene interaction predicts weight gain and obesity in women with seasonal affective disorder: A seasonal thrifty phenotype hypothesis
    Robert D Levitan
    Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, ON, Canada
    Neuropsychopharmacology 31:2498-503. 2006
    ..We speculate that these data may reflect the vestigial expression of a seasonal thrifty phenotype that contributed to the positive selection of the 7R allele over the past 40,000 years...
  63. ncbi request reprint Oxcarbazepine in the treatment of bipolar disorder: a review
    Wetid Pratoomsri
    Mood Disorders Centre of Excellence, University of British Columbia, Vancouver
    Can J Psychiatry 51:540-5. 2006
    ..To review the data on the efficacy of oxcarbazepine (OXC) in bipolar disorder (BD) and to provide recommendations for clinicians on the use of this medication in treating BD...
  64. doi request reprint Neurocognitive functioning in patients with bipolar I disorder recently recovered from a first manic episode
    Ivan J Torres
    Research Department, Riverview Hospital, British Columbia Mental Health and Addictions Services, Coquitlam, British Columbia, Canada
    J Clin Psychiatry 71:1234-42. 2010
    ..The purpose of this study was to determine whether neuropsychological impairments are present in clinically stable patients with bipolar disorder shortly after resolution of their first manic episode...
  65. ncbi request reprint Oxcarbazepine add-on in the treatment of refractory bipolar disorder
    Wetid Pratoomsri
    Mood Disorders Clinical Research Unit, The University of British Columbia, Vancouver, BC, Canada
    Bipolar Disord 7:37-42. 2005
    ..To assess the effectiveness and safety of oxcarbazepine (OXC) in bipolar disorder (BD) and related conditions...
  66. ncbi request reprint Perceived quality of life in patients with bipolar disorder. Does group psychoeducation have an impact?
    Erin E Michalak
    Department of Psychiatry, University of British Columbia, Vancouver
    Can J Psychiatry 50:95-100. 2005
    ..We aimed to assess the impact of a time-limited psychoeducation (PE) group therapy upon perceived QoL among patients with BD...
  67. ncbi request reprint A comparison of personality function among patients with seasonal depression, nonseasonal depression, and nonclinical participants
    Erin E Michalak
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    J Pers Disord 18:448-58. 2004
    ..The results demonstrated that the traits associated with seasonal and nonseasonal depression differ in degree, not kind...
  68. doi request reprint Effect of electroconvulsive therapy on brain 5-HT(2) receptors in major depression
    Lakshmi N Yatham
    UBC Department of Psychiatry, The University of British Columbia, UBC Hospital, 2255 Wesbrook Mall, Vancouver, BC V6T2A1, Canada
    Br J Psychiatry 196:474-9. 2010
    ..Positron emission tomography (PET) studies in individuals with depression confirmed that antidepressant medications reduce brain 5-HT(2) receptors, but the effects of ECT on these receptors in individuals with depression are unknown...
  69. ncbi request reprint Therapeutic mechanism in seasonal affective disorder: do fluoxetine and light operate through advancing circadian phase?
    Greg Murray
    Faculty of Life and Social Sciences, Swinburne University of Technology, Melbourne, Victoria, Australia
    Chronobiol Int 22:937-43. 2005
    ..The study therefore provides no evidence that circadian phase advance mediates the therapeutic mechanism in patients with SAD. Findings are discussed in terms of the limitations of the circadian measures employed...
  70. ncbi request reprint Evidence supports validity of seasonal affective disorder
    Erin E Michalak
    Can J Psychiatry 47:786; author reply 786-7. 2002
  71. ncbi request reprint Seasonal affective disorder: a clinical update
    Asa Westrin
    Department of Clinical Sciences, Division of Psychiatry, Lund University Hospital, Lund, Sweden
    Ann Clin Psychiatry 19:239-46. 2007
    ..Seasonal affective disorder (SAD) consists of recurrent major depressive episodes in the fall/winter with remissions in spring/summer...
  72. ncbi request reprint Which antidepressants have demonstrated superior efficacy? A review of the evidence
    Stuart A Montgomery
    Imperial College School of Medicine, University of London, UK
    Int Clin Psychopharmacol 22:323-9. 2007
    ..This review of published data found evidence that only a very few antidepressants are shown to be more effective than others...
  73. pmc Efficacy of escitalopram in the treatment of major depressive disorder compared with conventional selective serotonin reuptake inhibitors and venlafaxine XR: a meta-analysis
    Sidney H Kennedy
    Department of Psychiatry, University of Toronto, University Health Network, Ont
    J Psychiatry Neurosci 31:122-31. 2006
    ..We conducted a meta-analysis of studies in which escitalopram was compared with other antidepressants to assess the relative efficacy of these agents...
  74. ncbi request reprint Enhancing outcomes in the management of treatment resistant depression: a focus on atypical antipsychotics
    Sidney H Kennedy
    University Health Network, 200 Elizabeth Street, Eaton North, 8th Floor, Room 222 Toronto, ON M5G 2C4, Canada
    Bipolar Disord 5:36-47. 2003
    ..With today's therapeutic alternatives, full remission of depression is an attainable goal. For some patients, combination and augmentation strategies earlier in treatment may increase the likelihood of remission...
  75. pmc Clinical guidelines for depressive disorders. Summary of recommendations relevant to family physicians
    Sidney H Kennedy
    University Health Network, University of Toronto, Ontario
    Can Fam Physician 49:489-91. 2003
  76. ncbi request reprint Long-term and preventative treatment for seasonal affective disorder
    Asa Westrin
    Department of Clinical Sciences, Division of Psychiatry, Lund University Hospital, Lund, Sweden
    CNS Drugs 21:901-9. 2007
    ....
  77. ncbi request reprint Brightening depression
    Anna Wirz-Justice
    Science 303:467-9. 2004
  78. ncbi request reprint O sweet spot where art thou? Light treatment of Seasonal Affective Disorder and the circadian time of sleep
    Greg Murray
    Faculty of Life and Social Sciences, Swinburne University of Technology, PO Box 218 John St, Hawthorn 3122 Melbourne, Victoria, Australia
    J Affect Disord 90:227-31. 2006
    ..Findings are discussed in terms of the study's limitations and the experimental challenge of parsing independent and interacting contributions of sleep and circadian phase...
  79. pmc Reboxetine: a preliminary report on its use through the Special Access Program
    Sidney H Kennedy
    University Health Network, Department of Psychiatry, University of Toronto, Toronto, Ont
    J Psychiatry Neurosci 27:418-22. 2002
    ..To describe the effectiveness and tolerability of reboxetine under Special Access Program conditions in Canada in a group of patients with refractory depressive disorders...
  80. ncbi request reprint Electroretinography in patients with winter seasonal affective disorder
    Marc Hebert
    Department of Ophthalmology, Laval University Medical Research Center CHUQ, Faculty of Medicine, Laval University, Sainte Foy, Quebec, Canada
    Psychiatry Res 127:27-34. 2004
    ..We hypothesize that brain neurotransmitter dysregulation may be at the origin of both the mood disorder and retinal sensitivity change...
  81. pmc Bipolar spectrum disorders. New perspectives
    Andre Piver
    Nelson Mental Health Centre, Kootenay Lake Regional Hospital, Nelson, BC
    Can Fam Physician 48:896-904. 2002
    ..To review new perspectives on diagnosis, clinical features, epidemiology, and treatment of bipolar II and related disorders...
  82. ncbi request reprint Chronotherapeutics (light and wake therapy) in affective disorders
    Anna Wirz-Justice
    Psychol Med 35:939-44. 2005
    ..3) Given the urgent need for new strategies to treat patients with residual depressive symptoms, clinical trials of wake therapy and/or adjuvant light therapy, coupled with follow-up studies of long-term recurrence, are a high priority...
  83. ncbi request reprint Seasonal affective disorder: the latitude hypothesis revisited
    Erin E Michalak
    Can J Psychiatry 47:787-8. 2002