Research Topics
| R W LamSummaryAffiliation: University of British Columbia Country: Canada Publications
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Publications
The prevalence and impact of depression in self-referred clients attending an employee assistance programRaymond W Lam
Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada
J Occup Environ Med 54:1395-9. 2012..To determine the prevalence and characteristics of clients with depression attending an employee assistance program (EAP)...
Onset, time course and trajectories of improvement with antidepressantsRaymond W Lam
Department of Psychiatry, University of British Columbia, Mood Disorders Centre of Excellence, UBC Hospital, 2255 Wesbrook Mall, Vancouver, BC, Canada V6T 2A1
Eur Neuropsychopharmacol 22:S492-8. 2012..A lack of improvement (defined as ≤20% reduction from baseline in scores on a depression rating scale) at 2-3 weeks after initiation of an antidepressant should prompt the clinician to consider a change in management...
Quality of life in bipolar disorder: a review of the literatureErin E Michalak
Department of Psychiatry, University of British Columbia, Vancouver, Canada
Health Qual Life Outcomes 3:72. 2005..We identified several important avenues for future research, including a need for more assessment of QoL in hypo/manic patients, more longitudinal research and the development of a disease-specific measure of QoL for patients with BD...- A controlled trial of the Litebook light-emitting diode (LED) light therapy device for treatment of Seasonal Affective Disorder (SAD)Paul H Desan
Department of Psychiatry, Yale University, New Haven, CT 06520 8068, USA
BMC Psychiatry 7:38. 2007..Light treatment devices using efficient light-emitting diodes (LEDs) whose output is relatively concentrated in short wavelengths may enable a more convenient effective therapy for Seasonal Affective Disorder (SAD)... - Is remission of depressive symptoms in primary care a realistic goal? A meta-analysisMarliese Y Dawson
Division of Clinical Neuroscience, Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, Canada V6T 2A1
BMC Fam Pract 5:19. 2004..The goal of this study was to determine remission rates obtained in RCTs of treatment interventions for Major Depressive Disorder (MDD) conducted in primary care settings... - Canadian Network for Mood and Anxiety Treatments (CANMAT) clinical guidelines for the management of major depressive disorder in adults. III. PharmacotherapyRaymond W Lam
University of British Columbia, Canada
J Affect Disord 117:S26-43. 2009..A revision of these guidelines was undertaken by CANMAT in 2008-2009 to reflect advances in the field... - A new clinical rating scale for work absence and productivity: validation in patients with major depressive disorderRaymond W Lam
Department of Psychiatry, University of BC, Mood Disorders Centre, UBC Hospital, Vancouver, Canada
BMC Psychiatry 9:78. 2009..This study seeks to validate the Lam Employment Absence and Productivity Scale (LEAPS), a 10-item self-report questionnaire that takes 3-5 minutes to complete... - The influence of baseline severity on efficacy of escitalopram and citalopram in the treatment of major depressive disorder: an extended analysisR W Lam
University of British Columbia, Vancouver, British Columbia, Canada
Pharmacopsychiatry 39:180-4. 2006..To determine the differences between escitalopram and citalopram in the treatment of patients with major depressive disorder across a range of baseline severity of depression using trend analysis... - Efficacy, effectiveness and efficiency of escitalopram in the treatment of major depressive and anxiety disordersRaymond W Lam
Professor of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, V6T 2A1, Canada
Expert Rev Pharmacoecon Outcomes Res 7:559-76. 2007..Escitalopram has a prominent role in the treatment of major depressive disorder and anxiety disorders, and may also prove to be important in the treatment of mixed depressive anxiety disorder... - Repetitive transcranial magnetic stimulation for treatment-resistant depression: a systematic review and metaanalysisRaymond W Lam
Division of Clinical Neuroscience, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia
Can J Psychiatry 53:621-31. 2008..None have specifically examined outcomes in patients with treatment-resistant depression (TRD)... - The Can-SAD study: a randomized controlled trial of the effectiveness of light therapy and fluoxetine in patients with winter seasonal affective disorderRaymond W Lam
Mood Disorders Centre, UBC Hospital, 2255 Wesbrook Mall, Vancouver, BC V6T 2A1
Am J Psychiatry 163:805-12. 2006..This study compared the effectiveness of light therapy and an antidepressant within a single trial... - Escitalopram and duloxetine in the treatment of major depressive disorder: a pooled analysis of two trialsRaymond W Lam
Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
Int Clin Psychopharmacol 23:181-7. 2008..This pooled analysis shows that over an 8-week treatment period, escitalopram (10-20 mg/day) is superior in both effectiveness and tolerability compared with duloxetine (60 mg/day)... - Escitalopram versus serotonin noradrenaline reuptake inhibitors as second step treatment for patients with major depressive disorder: a pooled analysisRaymond W Lam
Department of Psychiatry, University of British Columbia, Mood Disorders Centre, UBC Hospital, Vancouver, Canada
Int Clin Psychopharmacol 25:199-203. 2010..These results should be confirmed in prospective randomized clinical trials... - Citalopram and bupropion-SR: combining versus switching in patients with treatment-resistant depressionRaymond W Lam
Division of Clinical Neuroscience, Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, V6T 2A1 Canada
J Clin Psychiatry 65:337-40. 2004..In this study, we compared the effects of combining citalopram and bupropion-SR versus switching to the other monotherapy in treatment-resistant depression... - Evidence-based strategies for achieving and sustaining full remission in depression: focus on metaanalysesRaymond W Lam
Department of Psychiatry, University of British Columbia, Vancouver
Can J Psychiatry 49:17S-26S. 2004..Randomized controlled clinical trials conducted in the last 5 years provide very good evidence to show that achieving and sustaining the fully remitted state is an attainable goal in the management of patients with depression... - High-quality remission: potential benefits of the melatonergic approach for patients with major depressive disorderRaymond W Lam
Division of Clinical Neuroscience, Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
Int Clin Psychopharmacol 22:S21-5. 2007.... - Does neuroimmune dysfunction mediate seasonal mood changes in winter depression?Raymond W Lam
Division of Clinical Neuroscience, Department of Psychiatry, University of British Columbia UBC, 2255 Wesbrook Mall, Vancouver, BC, Canada V6T 2A1
Med Hypotheses 63:567-73. 2004..The etiology of winter depression (seasonal affective disorder, or SAD) is not known, but a number of studies have provided support for both photoperiod and neurotransmitter hypotheses... - Combining antidepressants for treatment-resistant depression: a reviewRaymond W Lam
Division of Mood Disorders, Department of Psychiatry, University of British Columbia, UBC Hospital, Vancouver, British Columbia, Canada
J Clin Psychiatry 63:685-93. 2002..This review critically evaluates the evidence for efficacy of combining antidepressants... - The importance of early symptom relief in antidepressant treatment: focus on agomelatineRaymond W Lam
Department of Psychiatry, University of British Columbia, UBC Hospital, Vancouver, BC, Canada
J Psychopharmacol 24:27-30. 2010..These properties suggest that agomelatine can be considered a first-line treatment for patients with major depression... - Telephone-administered cognitive-behavioral therapy for clients with depressive symptoms in an employee assistance program: a pilot studyRaymond W Lam
Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
Ann Clin Psychiatry 23:11-6. 2011..To assess the clinical and work productivity effects of a brief intervention using telephone-administered cognitive-behavioral therapy (CBT) for clients with depressive symptoms attending an employee assistance program (EAP)... - Clinical effectiveness: the importance of psychosocial functioning outcomesRaymond W Lam
Department of Psychiatry, University of BC, Mood Disorders Centre, UBC Hospital, Vancouver, BC, Canada
J Affect Disord 132:S9-S13. 2011..However, clinical trials for depression have primarily focused on reduction in symptoms, as measured by symptom severity scales such as the HDRS and MADRS or by standard definitions of response and remission... - Addressing circadian rhythm disturbances in depressed patientsR W Lam
Division of Clinical Neuroscience, Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
J Psychopharmacol 22:13-8. 2008..These positive features provide a novel approach to the treatment of depression and the attainment of high-quality remission in MDD... - Using metaanalysis to evaluate evidence: practical tips and trapsRaymond W Lam
Division of Clinical Neuroscience, Department of Psychiatry, University of British Columbia, Vancouver
Can J Psychiatry 50:167-74. 2005..This paper focuses on basic principles and terms used in metaanalysis, so that clinicians can appropriately evaluate and use their results to guide treatment decisions... - Decrease in brain serotonin 2 receptor binding in patients with major depression following desipramine treatment: a positron emission tomography study with fluorine-18-labeled setoperoneL N Yatham
Division of Mood Disorders, The University of British Columbia, Vancouver, Canada
Arch Gen Psychiatry 56:705-11. 1999..Our purpose, therefore, was to assess the effects of treatment with desipramine hydrochloride on brain 5-HT2 receptors in depressed patients using positron emission tomography (PET) and fluorine-18 (18F)-labeled setoperone... - Brain serotonin2 receptors in major depression: a positron emission tomography studyL N Yatham
Mood Disorders Clinical Research Unit, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 2A1
Arch Gen Psychiatry 57:850-8. 2000..1 +/- 9.5 years; range, 22-60 years) and 20 healthy controls similar in age (37.2 +/- 12.6 years; range, 19-59 years) using positron emission tomography and setoperone labeled with fluorine 18 ([(18)F]setoperone)... - L-tryptophan augmentation of light therapy in patients with seasonal affective disorderR W Lam
Department of Psychiatry, University of British Columbia, Vancouver
Can J Psychiatry 42:303-6. 1997..Given the evidence for serotonergic dysregulation in SAD, we examined the possible role of l-tryptophan as an augmentation strategy for nonresponders and partial responders to light therapy... - Seasonal depression: the dual vulnerability hypothesis revisitedR W Lam
Division of Mood Disorders, Department of Psychiatry, University of British Columbia Hospital, Vancouver Hospital and Health Sciences Centre, 2255 Wesbrook Mall, BC, Canada V6T 2A1
J Affect Disord 63:123-32. 2001..In this study, we compare the clinical characteristics of these three seasonal groups and their response to light therapy... - An open trial of light therapy for women with seasonal affective disorder and comorbid bulimia nervosaR W Lam
Department of Psychiatry, University of British Columbia, Vancouver, Canada
J Clin Psychiatry 62:164-8. 2001..Controlled studies of light therapy in SAD and in bulimia nervosa have shown beneficial effects on mood and binge/purge symptoms. We explored the clinical use of light therapy in women with SAD who also had comorbid bulimia nervosa... - Effects of light therapy on suicidal ideation in patients with winter depressionR W Lam
Department of Psychiatry, University of British Columbia, and the University of British Columbia Hospital, Vancouver, Canada
J Clin Psychiatry 61:30-2. 2000..This retrospective study sought to determine the effects of light therapy on suicidal ideation in patients with SAD... - Clinical predictors of short-term outcome in electroconvulsive therapyR W Lam
Department of Psychiatry, University of British Columbia, Vancouver
Can J Psychiatry 44:158-63. 1999..This study examined ECT use in a university teaching hospital to determine predictors of short-term ECT outcome... - Gender differences in the heritability of seasonal mood changeK L Jang
Department of Psychiatry, University of British Columbia, Vancouver, Canada
Psychiatry Res 70:145-54. 1997..5%) and females (median, 30.5%). For both sexes, weight changes were not heritable. Sex-by-genotype analyses suggested that the genetic factors influencing female seasonality may not be the same as those influencing male seasonality... - A community-based clinic survey of antidepressant use in persons with schizophreniaR W Lam
Department of Psychiatry, University of British Columbia, Vancouver
Can J Psychiatry 43:513-6. 1998..To determine the rates of antidepressant and antipsychotic use in the treatment of schizophrenia... - A PET study of brain 5-HT2 receptors and their correlation with platelet 5-HT2 receptors in healthy humansL N Yatham
Division of Mood Disorders Clinical Research Unit, The University of British Columbia, Vancouver, Canada
Psychopharmacology (Berl) 151:424-7. 2000..Platelets share many properties with brain serotonergic neurons such as active 5-hydroxytryptamine (5-HT) transport, 5-HT2 receptors, and mitochondrial monoamine oxidase... - A controlled study of light therapy in women with late luteal phase dysphoric disorderR W Lam
Department of Psychiatry, University of British Columbia, Vancouver Hospital and Health Sciences Centre, Canada
Psychiatry Res 86:185-92. 1999..These results suggest that bright light therapy is an effective treatment for LLPDD... - Hypothermic, ACTH, and cortisol responses to ipsapirone in patients with mania and healthy controlsL N Yatham
Department of Psychiatry, The University of British Columbia, Vancouver, Canada
J Affect Disord 54:295-301. 1999.... - Personality and seasonal affective disorder: results from the CAN-SAD studyMurray W Enns
Department of Psychiatry, University of Manitoba, Canada
J Affect Disord 93:35-42. 2006..The present study investigated the relationship between the five-factor model of personality (neuroticism, extraversion, openness, agreeableness, conscientiousness) and SAD... - Effects of alpha-methyl-para-tyrosine-induced catecholamine depletion in patients with seasonal affective disorder in summer remissionR W Lam
Division of Mood Disorders, Department of Psychiatry, University of British Columbia, and UBC Hospital, Vancouver Hospital and Health Sciences Centre, Vancouver, B C, Canada
Neuropsychopharmacology 25:S97-101. 2001..AMPT-induced depressive relapse may be a trait marker for SAD, and/or brain catecholamines may play a direct role in the pathogenesis of SAD... - Quality of life as an outcome indicator in patients with seasonal affective disorder: results from the Can-SAD studyErin E Michalak
Division of Clinical Neuroscience, Department of Psychiatry, University of British Columbia, Vancouver, Canada
Psychol Med 37:727-36. 2007..We report here on results from the Can-SAD trial, which assessed the impact of treatment with either antidepressant medication or light therapy upon QoL in patients diagnosed with SAD... - Breaking the myths: new treatment approaches for chronic depressionErin E Michalak
Division of Mood Disorders, Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC V6T 2A1
Can J Psychiatry 47:635-43. 2002..In the past, chronic depression has been thought to be treatment-resistant, and evidence suggests that it is currently underdiagnosed, misdiagnosed, and suboptimally treated... - Seasonal mood change and personality: an investigation of genetic co-morbidityK L Jang
Department of Psychiatry, University of British Columbia, Vancouver, Canada
Psychiatry Res 78:1-7. 1998..19. These results provide evidence that the observed correlations between these seasonality and personality dimensions are attributable to common genetic factors and that environmental influences are domain specific... - The impact of childhood trauma on cognitive functioning in patients recently recovered from a first manic episode: Data from the Systematic Treatment Optimization Program for Early Mania (STOP-EM)J Bücker
Department of Psychiatry, University of British Columbia, Vancouver, Canada BC V6T2A1 Bipolar Disorder Program and Laboratory of Molecular Psychiatry, National Institute for Translational Medicine, INCT TM Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
J Affect Disord 148:424-30. 2013..The results require replication, but suggest that the co-occurrence of trauma and bipolar disorder can affect those cognitive areas that are already more susceptible in patients with BD... - Relationship between cognitive functioning and 6-month clinical and functional outcome in patients with first manic episode bipolar I disorderI J Torres
Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
Psychol Med 41:971-82. 2011..The purpose of this study was to evaluate the impact of cognitive functioning on longitudinal 6-month functional and clinical outcome in recently diagnosed clinically stable patients with bipolar disorder... - Pathophysiology of seasonal affective disorder: a reviewR W Lam
Division of Mood Disorders, Department of Psychiatry, University of British Columbia, UBC Hospital, Vancouver, BC
J Psychiatry Neurosci 25:469-80. 2000..Recent progress in defining the molecular mechanisms of the human circadian clock and retinal phototransduction of light will provide important new directions for future studies of the etiology and pathophysiology of SAD... - Effects of rapid tryptophan depletion on brain 5-HT(2) receptors: a PET studyL N Yatham
Division of Mood Disorders, The University of British Columbia, Canada
Br J Psychiatry 178:448-53. 2001..The mechanism by which rapid tryptophan depletion (RTD) paradigm induces depressive relapse in recently remitted patients with depression is unknown... - Mirtazapine for treatment-resistant depression: a preliminary reportDante D C Wan
Division of Mood Disorders, Department of Psychiatry, University of British Columbia and UBC Hospital, Vancouver, BC
J Psychiatry Neurosci 28:55-9. 2003..Further controlled studies are required to demonstrate the efficacy of mirtazapine in treatment-resistant depression... - Sleep disturbances and depression: a challenge for antidepressantsRaymond W Lam
Division of Clinical Neuroscience, Department of Psychiatry, University of British Columbia (UBC) and Mood Disorders Centre of Excellence, UBC Hospital, Vancouver, Canada
Int Clin Psychopharmacol 21:S25-9. 2006..It also describes a novel antidepressant, agomelatine, which improves symptoms of depression and rapidly relieves sleep complaints without sedative effects... - Course and outcome after the first manic episode in patients with bipolar disorder: prospective 12-month data from the Systematic Treatment Optimization Program For Early Mania projectLakshmi N Yatham
Mood Disorders Program, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia V6T 2A1
Can J Psychiatry 54:105-12. 2009..To describe clinical characteristics, course, and outcome during a 1-year period after the first manic episode in patients with bipolar disorder (BD)... - Treatment of seasonal affective disorder: unipolar versus bipolar differencesChang-Ho Sohn
Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, Canada V6T 2A1
Curr Psychiatry Rep 6:478-85. 2004..Chronobiological treatments such as bright light therapy may be combined with pharmacotherapy to enhance therapeutic effects, reduce adverse side effects, and optimize treatment in patients with seasonal and nonseasonal bipolar disorder... - Generic and health-related quality of life in patients with seasonal and nonseasonal depressionErin E Michalak
Division of Clinical Neuroscience, Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, Canada V6T 2A1
Psychiatry Res 128:245-51. 2004..Future research is required to determine whether perceived QoL is improved by treatment interventions for seasonal depression such as light therapy or antidepressant medication... - Hard times and good friends: negative life events and social support in patients with seasonal and nonseasonal depressionErin E Michalak
Department of Psychiatry, University of British Columbia UBC Hospital, VCHA, Vancouver, British Columbia
Can J Psychiatry 49:408-11. 2004..This study aimed to compare baseline levels of negative life events (NLEs) and perceived social support (SS) in patients with seasonal and nonseasonal depression... - Comparative efficacy of typical and atypical antipsychotics as add-on therapy to mood stabilizers in the treatment of acute maniaD S Miller
Department of Psychiatry, University of British Columbia, Vancouver, Canada
J Clin Psychiatry 62:975-80. 2001..atypical antipsychotics are an excellent choice as add-on therapy to mood stabilizers for the treatment of patients with mania... - Antidepressant-associated mood elevations in bipolar II disorder compared with bipolar I disorder and major depressive disorder: a systematic review and meta-analysisDavid J Bond
Research and International Affairs, Mood Disorders Centre, Department of Psychiatry, University of British Columbia, Room 2C7, 2255 Wesbrook Mall, Vancouver, BC V6T 2A1 Canada
J Clin Psychiatry 69:1589-601. 2008..The risk of antidepressant-associated mood elevations (AAME) in bipolar II disorder relative to bipolar I disorder and MDD is unknown... - A season-of-birth/DRD4 interaction predicts maximal body mass index in women with bulimia nervosaRobert D Levitan
Mood and Anxiety Division, Department of Psychiatry, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada
Neuropsychopharmacology 35:1729-33. 2010..9 vs 8.8%, respectively, p=0.008). These data offer further evidence that season of birth interacts with the 7R allele of DRD4 to influence body weight regulation in female overeating populations... - A magnetic resonance imaging study of mood stabilizer- and neuroleptic-naïve first-episode maniaLakshmi N Yatham
Division of Mood Disorders, University of British Columbia, Vancouver, BC, Canada
Bipolar Disord 9:693-7. 2007..Studies in first-episode (FE) manic patients have the potential to provide answers to these questions... - A comparison of open treatment of seasonal major and minor depression with light therapyAnthony J Levitt
Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
J Affect Disord 71:243-8. 2002..The current study evaluates 3 weeks of open treatment with light therapy in SAD and subsyndromal SAD patients... - Update on the biology of seasonal affective disorderChang-Ho Sohn
Mood Disorders Centre, University of British Columbia Hospital, Vancouver, British Columbia, Canada
CNS Spectr 10:635-46; quiz 1-14. 2005.... - A pilot study of adherence with light treatment for seasonal affective disorderErin E Michalak
Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall Vancouver, BC, Canada V6T 2A1
Psychiatry Res 149:315-20. 2007..Future research studies should routinely measure and evaluate adherence with light therapy and evidence-based techniques for maximising treatment adherence should be incorporated into routine clinical practice... - The dopamine-4 receptor gene associated with binge eating and weight gain in women with seasonal affective disorder: an evolutionary perspectiveRobert D Levitan
Mood and Anxiety Division, Centre for Addiction and Mental Health, University of Toronto, Department of Psychiatry, 250 College Street, Room 1126, Toronto, Ontario M5T 1R8, Canada
Biol Psychiatry 56:665-9. 2004..In this study, we examined whether binge eating behavior mediated this putative association... - Bipolar disorder and quality of life: a patient-centered perspectiveErin E Michalak
Division of Mood Disorders, Department of Psychiatry, University of British Columbia, Vancouver, BC V6T 2A1, Canada
Qual Life Res 15:25-37. 2006..We report here on a series of in-depth qualitative interviews we conducted as part of the item generation phase for a disease-specific scale to assess QoL in BD... - Antidepressant effects of exercise: evidence for an adult-neurogenesis hypothesis?Carl Ernst
Neuroscience Program, UBC Hospital, University of British Columbia, Vancouver, BC
J Psychiatry Neurosci 31:84-92. 2006..We conclude that there is evidence to support the hypothesis that exercise alleviates MDD and that several mechanisms exist that could mediate this effect through adult neurogenesis... - Quality of life in patients with seasonal affective disorder: summer vs winter scoresErin E Michalak
Department of Psychiatry, University of British Columbia, Vancouver
Can J Psychiatry 50:292-5. 2005..To compare perceived quality of life (QoL) in patients diagnosed with seasonal affective disorder (SAD) during the winter and summer months... - A birth-season/DRD4 gene interaction predicts weight gain and obesity in women with seasonal affective disorder: A seasonal thrifty phenotype hypothesisRobert D Levitan
Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, ON, Canada
Neuropsychopharmacology 31:2498-503. 2006..We speculate that these data may reflect the vestigial expression of a seasonal thrifty phenotype that contributed to the positive selection of the 7R allele over the past 40,000 years... - Oxcarbazepine in the treatment of bipolar disorder: a reviewWetid Pratoomsri
Mood Disorders Centre of Excellence, University of British Columbia, Vancouver
Can J Psychiatry 51:540-5. 2006.... - Neurocognitive functioning in patients with bipolar I disorder recently recovered from a first manic episodeIvan J Torres
Research Department, Riverview Hospital, British Columbia Mental Health and Addictions Services, Coquitlam, British Columbia, Canada
J Clin Psychiatry 71:1234-42. 2010..The purpose of this study was to determine whether neuropsychological impairments are present in clinically stable patients with bipolar disorder shortly after resolution of their first manic episode... - Oxcarbazepine add-on in the treatment of refractory bipolar disorderWetid Pratoomsri
Mood Disorders Clinical Research Unit, The University of British Columbia, Vancouver, BC, Canada
Bipolar Disord 7:37-42. 2005..CONCLUSION: OXC was effective and well-tolerated in refractory BD and schizoaffective disorder. These preliminary data are promising but controlled studies are needed to confirm its efficacy in refractory BD... - Perceived quality of life in patients with bipolar disorder. Does group psychoeducation have an impact?Erin E Michalak
Department of Psychiatry, University of British Columbia, Vancouver
Can J Psychiatry 50:95-100. 2005..We aimed to assess the impact of a time-limited psychoeducation (PE) group therapy upon perceived QoL among patients with BD... - A comparison of personality function among patients with seasonal depression, nonseasonal depression, and nonclinical participantsErin E Michalak
Department of Psychiatry, University of British Columbia, Vancouver, Canada
J Pers Disord 18:448-58. 2004..The results demonstrated that the traits associated with seasonal and nonseasonal depression differ in degree, not kind... - Effect of electroconvulsive therapy on brain 5-HT(2) receptors in major depressionLakshmi N Yatham
UBC Department of Psychiatry, The University of British Columbia, UBC Hospital, 2255 Wesbrook Mall, Vancouver, BC V6T2A1, Canada
Br J Psychiatry 196:474-9. 2010..Positron emission tomography (PET) studies in individuals with depression confirmed that antidepressant medications reduce brain 5-HT(2) receptors, but the effects of ECT on these receptors in individuals with depression are unknown... - Therapeutic mechanism in seasonal affective disorder: do fluoxetine and light operate through advancing circadian phase?Greg Murray
Faculty of Life and Social Sciences, Swinburne University of Technology, Melbourne, Victoria, Australia
Chronobiol Int 22:937-43. 2005..The study therefore provides no evidence that circadian phase advance mediates the therapeutic mechanism in patients with SAD. Findings are discussed in terms of the limitations of the circadian measures employed... - Evidence supports validity of seasonal affective disorderErin E Michalak
Can J Psychiatry 47:786; author reply 786-7. 2002 - Seasonal affective disorder: a clinical updateAsa Westrin
Department of Clinical Sciences, Division of Psychiatry, Lund University Hospital, Lund, Sweden
Ann Clin Psychiatry 19:239-46. 2007..Seasonal affective disorder (SAD) consists of recurrent major depressive episodes in the fall/winter with remissions in spring/summer... - Which antidepressants have demonstrated superior efficacy? A review of the evidenceStuart A Montgomery
Imperial College School of Medicine, University of London, UK
Int Clin Psychopharmacol 22:323-9. 2007..This review of published data found evidence that only a very few antidepressants are shown to be more effective than others... - Efficacy of escitalopram in the treatment of major depressive disorder compared with conventional selective serotonin reuptake inhibitors and venlafaxine XR: a meta-analysisSidney H Kennedy
Department of Psychiatry, University of Toronto, University Health Network, Ont
J Psychiatry Neurosci 31:122-31. 2006..We conducted a meta-analysis of studies in which escitalopram was compared with other antidepressants to assess the relative efficacy of these agents... - Enhancing outcomes in the management of treatment resistant depression: a focus on atypical antipsychoticsSidney H Kennedy
University Health Network, 200 Elizabeth Street, Eaton North, 8th Floor, Room 222 Toronto, ON M5G 2C4, Canada
Bipolar Disord 5:36-47. 2003..With today's therapeutic alternatives, full remission of depression is an attainable goal. For some patients, combination and augmentation strategies earlier in treatment may increase the likelihood of remission... - Clinical guidelines for depressive disorders. Summary of recommendations relevant to family physiciansSidney H Kennedy
University Health Network, University of Toronto, Ontario
Can Fam Physician 49:489-91. 2003 - Long-term and preventative treatment for seasonal affective disorderAsa Westrin
Department of Clinical Sciences, Division of Psychiatry, Lund University Hospital, Lund, Sweden
CNS Drugs 21:901-9. 2007.... - Brightening depressionAnna Wirz-Justice
Science 303:467-9. 2004 - O sweet spot where art thou? Light treatment of Seasonal Affective Disorder and the circadian time of sleepGreg Murray
Faculty of Life and Social Sciences, Swinburne University of Technology, PO Box 218 John St, Hawthorn 3122 Melbourne, Victoria, Australia
J Affect Disord 90:227-31. 2006..Findings are discussed in terms of the study's limitations and the experimental challenge of parsing independent and interacting contributions of sleep and circadian phase... - Reboxetine: a preliminary report on its use through the Special Access ProgramSidney H Kennedy
University Health Network, Department of Psychiatry, University of Toronto, Toronto, Ont
J Psychiatry Neurosci 27:418-22. 2002..To describe the effectiveness and tolerability of reboxetine under Special Access Program conditions in Canada in a group of patients with refractory depressive disorders... - Electroretinography in patients with winter seasonal affective disorderMarc Hebert
Department of Ophthalmology, Laval University Medical Research Center CHUQ, Faculty of Medicine, Laval University, Sainte Foy, Quebec, Canada
Psychiatry Res 127:27-34. 2004..We hypothesize that brain neurotransmitter dysregulation may be at the origin of both the mood disorder and retinal sensitivity change... - Bipolar spectrum disorders. New perspectivesAndre Piver
Nelson Mental Health Centre, Kootenay Lake Regional Hospital, Nelson, BC
Can Fam Physician 48:896-904. 2002..To review new perspectives on diagnosis, clinical features, epidemiology, and treatment of bipolar II and related disorders... - Chronotherapeutics (light and wake therapy) in affective disordersAnna Wirz-Justice
Psychol Med 35:939-44. 2005..3) Given the urgent need for new strategies to treat patients with residual depressive symptoms, clinical trials of wake therapy and/or adjuvant light therapy, coupled with follow-up studies of long-term recurrence, are a high priority... - Seasonal affective disorder: the latitude hypothesis revisitedErin E Michalak
Can J Psychiatry 47:787-8. 2002