Research Topics


Dale W Laird


Affiliation: University of Western Ontario
Country: Canada


  1. Novielli Kuntz N, Jelen M, Barr K, DeLalio L, Feng Q, Isakson B, et al. Ablation of both Cx40 and Panx1 results in similar cardiovascular phenotypes exhibited in Cx40 knockout mice. Biosci Rep. 2019;39: pubmed publisher
    ..Nevertheless, the augmented renin homeostasis observed in the double knockout mice suggests that both Cx40 and Panx1 may play an integrative role. ..
  2. Kelly J, Shao Q, Jagger D, Laird D. Cx30 exhibits unique characteristics including a long half-life when assembled into gap junctions. J Cell Sci. 2015;128:3947-60 pubmed publisher
    ..In summary, Cx30 was found to be an unusually stable, long-lived connexin (half-life >12 h), which may underlie its specific role in the epidermis and cochlea. ..
  3. Abitbol J, Kelly J, Barr K, Allman B, Laird D. Mice harbouring an oculodentodigital dysplasia-linked Cx43 G60S mutation have severe hearing loss. J Cell Sci. 2018;131: pubmed publisher
    ..Taken together, this study suggests that Cx43 plays an important role in baseline hearing and is essential for auditory processing.This article has an associated First Person interview with the first author of the paper. ..
  4. Stewart M, Simek J, Laird D. Insights into the role of connexins in mammary gland morphogenesis and function. Reproduction. 2015;149:R279-90 pubmed publisher
    ..Yet, there remain gaps in our understanding of the role of mammary gland gap junctions. ..
  5. Esseltine J, Shao Q, Huang T, Kelly J, SAMPSON J, Laird D. Manipulating Cx43 expression triggers gene reprogramming events in dermal fibroblasts from oculodentodigital dysplasia patients. Biochem J. 2015;472:55-69 pubmed publisher
    ..These findings further illuminate the altered function of Cx43 in ODDD-affected individuals and highlight the impact of manipulating Cx43 expression in human cells. ..
  6. Merrifield P, Laird D. Connexins in skeletal muscle development and disease. Semin Cell Dev Biol. 2016;50:67-73 pubmed publisher
    ..This review will focus on the role connexins play in muscle development and repair and discuss the impact of Cx43 mutants on muscle function. ..
  7. Kelly J, Esseltine J, Shao Q, Jabs E, SAMPSON J, Auranen M, et al. Specific functional pathologies of Cx43 mutations associated with oculodentodigital dysplasia. Mol Biol Cell. 2016;27:2172-85 pubmed publisher
    ..Together these findings enabled us to discover mutation-specific pathologies that may help to predict future clinical outcomes. ..
  8. Laird D. Closing the gap on autosomal dominant connexin-26 and connexin-43 mutants linked to human disease. J Biol Chem. 2008;283:2997-3001 pubmed
  9. Shao Q, Lindstrom K, Shi R, Kelly J, Schroeder A, Juusola J, et al. A Germline Variant in the PANX1 Gene Has Reduced Channel Function and Is Associated with Multisystem Dysfunction. J Biol Chem. 2016;291:12432-43 pubmed publisher
    ..Collectively, we demonstrate a PANX1 missense change associated with human disease in the first report of a "PANX1-related disorder." ..

More Information


  1. Esseltine J, Laird D. Next-Generation Connexin and Pannexin Cell Biology. Trends Cell Biol. 2016;26:944-955 pubmed publisher
  2. Press E, Shao Q, Kelly J, Chin K, Alaga A, Laird D. Induction of cell death and gain-of-function properties of connexin26 mutants predict severity of skin disorders and hearing loss. J Biol Chem. 2017;292:9721-9732 pubmed publisher
    ..Moreover, cell death-inducing GJB2 mutations lead to more severe syndromic disease. ..