Research Topics

Species

Dale W Laird

Summary

Affiliation: University of Western Ontario
Country: Canada

Publications

  1. Merrifield P, Laird D. Connexins in skeletal muscle development and disease. Semin Cell Dev Biol. 2016;50:67-73 pubmed publisher
    ..This review will focus on the role connexins play in muscle development and repair and discuss the impact of Cx43 mutants on muscle function. ..
  2. Kelly J, Esseltine J, Shao Q, Jabs E, SAMPSON J, Auranen M, et al. Specific functional pathologies of Cx43 mutations associated with oculodentodigital dysplasia. Mol Biol Cell. 2016;27:2172-85 pubmed publisher
    ..Together these findings enabled us to discover mutation-specific pathologies that may help to predict future clinical outcomes. ..
  3. Laird D. Closing the gap on autosomal dominant connexin-26 and connexin-43 mutants linked to human disease. J Biol Chem. 2008;283:2997-3001 pubmed
    ....
  4. Shao Q, Lindstrom K, Shi R, Kelly J, Schroeder A, Juusola J, et al. A Germline Variant in the PANX1 Gene Has Reduced Channel Function and Is Associated with Multisystem Dysfunction. J Biol Chem. 2016;291:12432-43 pubmed publisher
    ..Collectively, we demonstrate a PANX1 missense change associated with human disease in the first report of a "PANX1-related disorder." ..
  5. Esseltine J, Laird D. Next-Generation Connexin and Pannexin Cell Biology. Trends Cell Biol. 2016;26:944-955 pubmed publisher
    ....
  6. Press E, Shao Q, Kelly J, Chin K, Alaga A, Laird D. Induction of cell death and gain-of-function properties of connexin26 mutants predict severity of skin disorders and hearing loss. J Biol Chem. 2017;292:9721-9732 pubmed publisher
    ..Moreover, cell death-inducing GJB2 mutations lead to more severe syndromic disease. ..

Locale

Detail Information

Publications6

  1. Merrifield P, Laird D. Connexins in skeletal muscle development and disease. Semin Cell Dev Biol. 2016;50:67-73 pubmed publisher
    ..This review will focus on the role connexins play in muscle development and repair and discuss the impact of Cx43 mutants on muscle function. ..
  2. Kelly J, Esseltine J, Shao Q, Jabs E, SAMPSON J, Auranen M, et al. Specific functional pathologies of Cx43 mutations associated with oculodentodigital dysplasia. Mol Biol Cell. 2016;27:2172-85 pubmed publisher
    ..Together these findings enabled us to discover mutation-specific pathologies that may help to predict future clinical outcomes. ..
  3. Laird D. Closing the gap on autosomal dominant connexin-26 and connexin-43 mutants linked to human disease. J Biol Chem. 2008;283:2997-3001 pubmed
    ....
  4. Shao Q, Lindstrom K, Shi R, Kelly J, Schroeder A, Juusola J, et al. A Germline Variant in the PANX1 Gene Has Reduced Channel Function and Is Associated with Multisystem Dysfunction. J Biol Chem. 2016;291:12432-43 pubmed publisher
    ..Collectively, we demonstrate a PANX1 missense change associated with human disease in the first report of a "PANX1-related disorder." ..
  5. Esseltine J, Laird D. Next-Generation Connexin and Pannexin Cell Biology. Trends Cell Biol. 2016;26:944-955 pubmed publisher
    ....
  6. Press E, Shao Q, Kelly J, Chin K, Alaga A, Laird D. Induction of cell death and gain-of-function properties of connexin26 mutants predict severity of skin disorders and hearing loss. J Biol Chem. 2017;292:9721-9732 pubmed publisher
    ..Moreover, cell death-inducing GJB2 mutations lead to more severe syndromic disease. ..