Dale W Laird

Summary

Affiliation: University of Western Ontario
Country: Canada

Publications

  1. ncbi request reprint Rat epidermal keratinocytes as an organotypic model for examining the role of Cx43 and Cx26 in skin differentiation
    Amy C Maher
    Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada
    Cell Commun Adhes 12:219-30. 2005
  2. pmc Life cycle of connexins in health and disease
    Dale W Laird
    Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada N6A 5C1
    Biochem J 394:527-43. 2006
  3. ncbi request reprint Closing the gap on autosomal dominant connexin-26 and connexin-43 mutants linked to human disease
    Dale W Laird
    Departments of Anatomy and Cell Biology and Physiology and Pharmacology, University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Biol Chem 283:2997-3001. 2008
  4. doi request reprint The gap junction proteome and its relationship to disease
    Dale W Laird
    Department of Anatomy and Cell Biology, and Physiology and Pharmacology, University of Western Ontario, London, Ontario N6A 5C1, Canada
    Trends Cell Biol 20:92-101. 2010
  5. doi request reprint The tumor-suppressive function of Connexin43 in keratinocytes is mediated in part via interaction with caveolin-1
    Stephanie Langlois
    Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada
    Cancer Res 70:4222-32. 2010
  6. doi request reprint Implications of pannexin 1 and pannexin 3 for keratinocyte differentiation
    Steven J Celetti
    Department of Physiology and Pharmacology, University of Western Ontario, London, ON, Canada
    J Cell Sci 123:1363-72. 2010
  7. ncbi request reprint Differential potency of dominant negative connexin43 mutants in oculodentodigital dysplasia
    Xiang Qun Gong
    Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Biol Chem 282:19190-202. 2007
  8. pmc Pannexin1 and pannexin3 delivery, cell surface dynamics, and cytoskeletal interactions
    Ruchi Bhalla-Gehi
    Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Biol Chem 285:9147-60. 2010
  9. doi request reprint Fate of connexin43 in cardiac tissue harbouring a disease-linked connexin43 mutant
    Janet L Manias
    Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada
    Cardiovasc Res 80:385-95. 2008
  10. pmc Caveolin-1 and -2 interact with connexin43 and regulate gap junctional intercellular communication in keratinocytes
    Stephanie Langlois
    Department of Anatomy and Cell Biology, University of Western Ontario, London, ON N6A 5C1, Canada
    Mol Biol Cell 19:912-28. 2008

Collaborators

  • Donglin Bai
  • Gerald M Kidder
  • Hong Qin
  • Moulay A Alaoui-Jamali
  • Dan Tong
  • Tao Huang
  • Andrew Macdonald
  • Hong Liu
  • Jessica Kalra
  • Qin Liu
  • Xiaowei Wang
  • Jack Lee
  • Trond Aasen
  • Brian J Nieman
  • GINA ELLEN SOSINSKY
  • ROSS JOHNSON
  • Mary Ann Pollmann
  • Alexander M Ferreira
  • Qing Shao
  • Jared M Churko
  • Silvia Penuela
  • Xiang Qun Gong
  • Stephanie Langlois
  • Elizabeth McLachlan
  • Tamsin Thomas
  • Isabelle Plante
  • Cindy M L Hutnik
  • Kyle N Cowan
  • Steven J Celetti
  • Janet L Manias
  • Ruchi Gehi
  • Cady E Pocrnich
  • Jared Churko
  • Bryce J Cowan
  • Ruchi Bhalla
  • Jamie Simek
  • Amy C Maher
  • Michael K G Stewart
  • Wendi Roscoe
  • Gregory I L Veitch
  • JACINDA SAMPSON
  • Edmund Tsui
  • Ruchi Bhalla-Gehi
  • Guo Yu
  • Kakon Nag
  • Naznin Sultana
  • Suzanne M Bernier
  • Maite Hernandez
  • Crystal S Lounsbury
  • Ann M Flenniken
  • Joanne E I Gittens
  • Gregory I Veitch
  • Guido Gaietta
  • Kevin J Barr
  • Glenn I Fishman
  • David W Litchfield
  • Sarah Harasym
  • Laszlo Gyenis
  • Melissa Savage
  • Amber Ablack
  • Mary M Feng
  • Sarit Khimdas
  • Robert Lorentz
  • Amy C Berger
  • John D Lewis
  • Gary S Shaw
  • John J Kelly
  • Jason Chan
  • Daniel Paluzzi
  • Kathleen A Hill
  • Kathryn J Swoboda
  • Ilia Kisilevsky
  • J Godfrey Heathcote
  • Alex M Laliberte
  • Andrea Wallis
  • Xinyue Pan
  • Karel Tyml
  • Michael Bolon
  • Kazuyuki Hoshijima
  • Shigehisa Hirose
  • Atsushi Kawakami
  • Gerald Batist
  • Mustapha Kandouz
  • Hong Ling Wang
  • Shi Ping Luh
  • Xiang Jiao Yang
  • Janet E Henderson
  • Crystal Lounsbury
  • Benoit G Bruneau
  • Igor Vukobradovic

Detail Information

Publications60

  1. ncbi request reprint Rat epidermal keratinocytes as an organotypic model for examining the role of Cx43 and Cx26 in skin differentiation
    Amy C Maher
    Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada
    Cell Commun Adhes 12:219-30. 2005
    ....
  2. pmc Life cycle of connexins in health and disease
    Dale W Laird
    Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada N6A 5C1
    Biochem J 394:527-43. 2006
    ..This review will assess the current understanding of wild-type and selected disease-linked mutant connexin transport through the secretory pathway, gap-junction assembly at the cell surface, internalization and degradation...
  3. ncbi request reprint Closing the gap on autosomal dominant connexin-26 and connexin-43 mutants linked to human disease
    Dale W Laird
    Departments of Anatomy and Cell Biology and Physiology and Pharmacology, University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Biol Chem 283:2997-3001. 2008
    ....
  4. doi request reprint The gap junction proteome and its relationship to disease
    Dale W Laird
    Department of Anatomy and Cell Biology, and Physiology and Pharmacology, University of Western Ontario, London, Ontario N6A 5C1, Canada
    Trends Cell Biol 20:92-101. 2010
    ....
  5. doi request reprint The tumor-suppressive function of Connexin43 in keratinocytes is mediated in part via interaction with caveolin-1
    Stephanie Langlois
    Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada
    Cancer Res 70:4222-32. 2010
    ....
  6. doi request reprint Implications of pannexin 1 and pannexin 3 for keratinocyte differentiation
    Steven J Celetti
    Department of Physiology and Pharmacology, University of Western Ontario, London, ON, Canada
    J Cell Sci 123:1363-72. 2010
    ..In summary, Panx1 and Panx3 are coexpressed in the mammalian epidermis, and the regulation of Panx1 plays a key role in keratinocyte differentiation...
  7. ncbi request reprint Differential potency of dominant negative connexin43 mutants in oculodentodigital dysplasia
    Xiang Qun Gong
    Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Biol Chem 282:19190-202. 2007
    ..The potency difference in the dominant negative properties of ODDD-linked Cx43 mutants may have clinical implications for the various symptoms and disease severity observed in ODDD patients...
  8. pmc Pannexin1 and pannexin3 delivery, cell surface dynamics, and cytoskeletal interactions
    Ruchi Bhalla-Gehi
    Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Biol Chem 285:9147-60. 2010
    ..Importantly, Panx1 has an interaction with actin microfilaments that regulates its cell surface localization and mobility...
  9. doi request reprint Fate of connexin43 in cardiac tissue harbouring a disease-linked connexin43 mutant
    Janet L Manias
    Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada
    Cardiovasc Res 80:385-95. 2008
    ....
  10. pmc Caveolin-1 and -2 interact with connexin43 and regulate gap junctional intercellular communication in keratinocytes
    Stephanie Langlois
    Department of Anatomy and Cell Biology, University of Western Ontario, London, ON N6A 5C1, Canada
    Mol Biol Cell 19:912-28. 2008
    ..Our results suggest that the Cx43/Cavs association occurs during exocytic transport, and they clearly indicate that caveolin regulates GJIC...
  11. doi request reprint The G60S Cx43 mutant enhances keratinocyte proliferation and differentiation
    Jared M Churko
    Department of Anatomy and Cell Biology, University of Western Ontario, London, ON, Canada
    Exp Dermatol 21:612-8. 2012
    ..Thus, we conclude that during wound healing, mutant Cx43 may enhance keratinocyte proliferation and promote early differentiation of keratinocytes...
  12. pmc Oogenesis defects in a mutant mouse model of oculodentodigital dysplasia
    Dan Tong
    Department of Physiology and Pharmacology, The University of Western Ontario, London, Canada
    Dis Model Mech 2:157-67. 2009
    ..We conclude that the Gja1(Jrt) mutation has a dominant negative effect on Cx43 function in the ovary, rendering the females subfertile. Given these findings, closer examination of reproductive function in ODDD human females is warranted...
  13. doi request reprint Autosomal recessive GJA1 (Cx43) gene mutations cause oculodentodigital dysplasia by distinct mechanisms
    Tao Huang
    Department of Anatomy and Cell Biology, University of Western Ontario, London ON N6A 5C1, Canada
    J Cell Sci 126:2857-66. 2013
    ....
  14. pmc The severity of mammary gland developmental defects is linked to the overall functional status of Cx43 as revealed by genetically modified mice
    Michael K G Stewart
    Department of Physiology and Pharmacology, Western University, London, ON, Canada N6A 5C1
    Biochem J 449:401-13. 2013
    ....
  15. ncbi request reprint Connexin levels regulate keratinocyte differentiation in the epidermis
    Stephanie Langlois
    Department of Anatomy and Cell Biology, The University of Western Ontario, London, Ontario, N6A 5C1, Canada
    J Biol Chem 282:30171-80. 2007
    ..Altogether, these studies provide an explanation as to why the vast majority of ODDD patients, where Cx43 function is highly compromised, do not suffer from skin disease...
  16. ncbi request reprint Functional characterization of oculodentodigital dysplasia-associated Cx43 mutants
    Elizabeth McLachlan
    Department of Anatomy and Cell Biology, The University of Western Ontario, London, Ontario, Canada
    Cell Commun Adhes 12:279-92. 2005
    ..Thus, we hypothesize that the bone phenotype of ODDD patients may result from disrupted gap junctional intercellular communication earlier in development or during bone remodeling...
  17. doi request reprint Diverse subcellular distribution profiles of pannexin 1 and pannexin 3
    Silvia Penuela
    Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada
    Cell Commun Adhes 15:133-42. 2008
    ..Collectively, diverse expression and distribution profiles of Panx1 and Panx3 suggest that they may have multiple cellular functions...
  18. ncbi request reprint Down-regulation of Cx43 by retroviral delivery of small interfering RNA promotes an aggressive breast cancer cell phenotype
    Qing Shao
    Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada
    Cancer Res 65:2705-11. 2005
    ..Taken together, these results suggest that Cx43 is required for maintaining cell differentiation and the regulation of molecules important in angiogenesis...
  19. doi request reprint Cx43 has distinct mobility within plasma-membrane domains, indicative of progressive formation of gap-junction plaques
    Jamie Simek
    Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Cell Sci 122:554-62. 2009
    ....
  20. ncbi request reprint Cx26 inhibits breast MDA-MB-435 cell tumorigenic properties by a gap junctional intercellular communication-independent mechanism
    Jessica Kalra
    Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada N6A 5C1
    Carcinogenesis 27:2528-37. 2006
    ....
  21. doi request reprint The G60S connexin43 mutant regulates hair growth and hair fiber morphology in a mouse model of human oculodentodigital dysplasia
    Jared M Churko
    Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada
    J Invest Dermatol 131:2197-204. 2011
    ..These results suggest that the G60S mutant mouse model mimics the hair phenotype found in at least some ODDD patients and suggests an important role for Cx43 in hair regeneration, growth, and cuticle formation...
  22. doi request reprint ODDD-linked Cx43 mutants reduce endogenous Cx43 expression and function in osteoblasts and inhibit late stage differentiation
    Elizabeth McLachlan
    Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada
    J Bone Miner Res 23:928-38. 2008
    ..The disease is characterized by craniofacial bone deformities and limb abnormalities. It is our hypothesis that Cx43 mutation causes osteoblast dysfunction, which may contribute to the bone phenotype of ODDD...
  23. ncbi request reprint Lysosomal and proteasomal degradation play distinct roles in the life cycle of Cx43 in gap junctional intercellular communication-deficient and -competent breast tumor cells
    Hong Qin
    Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Biol Chem 278:30005-14. 2003
    ..Overall proteasomal degradation regulates the stability of phosphorylated Cx43 and appears to promote the internalization of Cx43 from the cell surface...
  24. pmc Glycosylation regulates pannexin intermixing and cellular localization
    Silvia Penuela
    Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario N6A 5C1, Canada
    Mol Biol Cell 20:4313-23. 2009
    ..Collectively, these results reveal that the functional state and cellular distribution of mouse pannexins are regulated by their glycosylation status and interactions among pannexin family members...
  25. pmc The potency of the fs260 connexin43 mutant to impair keratinocyte differentiation is distinct from other disease-linked connexin43 mutants
    Jared M Churko
    Department of Anatomy and Cell Biology, University of Western Ontario, London, Canada
    Biochem J 429:473-83. 2010
    ..Collectively, our results suggest that the increased skin disease burden exhibited in ODDD patients harbouring the fs260 mutant is probably due to multiple additive effects cause by the mutant during epidermal differentiation...
  26. doi request reprint Gap junction remodeling in skin repair following wounding and disease
    Jared M Churko
    Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada
    Physiology (Bethesda) 28:190-8. 2013
    ..We also consider the therapeutic value of targeting connexins in wound healing...
  27. pmc Structure and functional studies of N-terminal Cx43 mutants linked to oculodentodigital dysplasia
    Qing Shao
    Department of Anatomy and Cell Biology, University of Western Ontario, London, ON N6A 5C1, Canada
    Mol Biol Cell 23:3312-21. 2012
    ..Collectively, these studies suggest that the nature of the mutation conveys loss of Cx43 function by distinctly different mechanisms that are rooted in the structure of the N-terminal region...
  28. ncbi request reprint Connexins act as tumor suppressors in three-dimensional mammary cell organoids by regulating differentiation and angiogenesis
    Elizabeth McLachlan
    Departments of Anatomy and Cell Biology and Physiology and Pharmacology, The University of Western Ontario, London, Ontario, Canada
    Cancer Res 66:9886-94. 2006
    ..In summary, Cx26 and Cx43 inhibit the malignant properties of MDA-MB-231 cells via GJIC-independent mechanisms, including regulation of EMT and angiogenesis...
  29. ncbi request reprint Differentiation of organotypic epidermis in the presence of skin disease-linked dominant-negative Cx26 mutants and knockdown Cx26
    Tamsin Thomas
    Department of Anatomy and Cell Biology, University of Western Ontario, London, ON, Canada
    J Membr Biol 217:93-104. 2007
    ....
  30. pmc Connexin 43 mediated gap junctional communication enhances breast tumor cell diapedesis in culture
    Mary Ann Pollmann
    Department of Anatomy and Cell Biology, The University of Western Ontario, London, Ontario, Canada
    Breast Cancer Res 7:R522-34. 2005
    ..The molecular mechanisms regulating tumor cell diapedesis are poorly understood, but may involve heterocellular gap junctional intercellular communication (GJIC) between tumor cells and endothelial cells...
  31. ncbi request reprint Connexin26 regulates the expression of angiogenesis-related genes in human breast tumor cells by both GJIC-dependent and -independent mechanisms
    Hong Qin
    Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada
    Cell Commun Adhes 10:387-93. 2003
    ..CTGF mRNA and protein levels were found to be down-regulated by both Cx26 and GFP-Cx26. Thus, our data indicates that Cx26 regulates angiogenesis-related molecules by mechanisms that are both GJIC-dependent and -independent...
  32. doi request reprint Milk secretion and ejection are impaired in the mammary gland of mice harboring a Cx43 mutant while expression and localization of tight and adherens junction proteins remain unchanged
    Isabelle Plante
    Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada
    Biol Reprod 82:837-47. 2010
    ....
  33. pmc A dominant loss-of-function GJA1 (Cx43) mutant impairs parturition in the mouse
    Dan Tong
    Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, The University of Western Ontario, Ontario, Canada
    Biol Reprod 80:1099-106. 2009
    ..We conclude that the Gja1(Jrt) mutation has a dominant-negative effect on Cx43 function in the myometrium, severely reducing GJIC, leading to impaired parturition...
  34. ncbi request reprint Functional domain mapping and selective trans-dominant effects exhibited by Cx26 disease-causing mutations
    Tamsin Thomas
    Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Biol Chem 279:19157-68. 2004
    ....
  35. ncbi request reprint Functional characterization of a GJA1 frameshift mutation causing oculodentodigital dysplasia and palmoplantar keratoderma
    Xiang Qun Gong
    Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Biol Chem 281:31801-11. 2006
    ..These results suggest that the 46 aberrant amino acid residues associated with the frameshift mutant are, at least in part, responsible for the manifestation of palmoplantar keratoderma symptoms...
  36. pmc Pathways regulating the trafficking and turnover of pannexin1 protein and the role of the C-terminal domain
    Ruchi Gehi
    Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Biol Chem 286:27639-53. 2011
    ....
  37. ncbi request reprint Selective assembly of connexin37 into heterocellular gap junctions at the oocyte/granulosa cell interface
    Gregory I Veitch
    Department of Physiology and Pharmacology, The University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Cell Sci 117:2699-707. 2004
    ....
  38. ncbi request reprint Pannexin 1 and pannexin 3 are glycoproteins that exhibit many distinct characteristics from the connexin family of gap junction proteins
    Silvia Penuela
    Department of Anatomy and Cell Biology, University of Western Ontario, London, ON, N6A 5C1, Canada
    J Cell Sci 120:3772-83. 2007
    ..Collectively, these studies show that Panx1 and Panx3 have many characteristics that are distinct from Cx43 and that these proteins probably play an important biological role as single membrane channels...
  39. doi request reprint The effect of connexin43 on the level of vascular endothelial growth factor in human retinal pigment epithelial cells
    Cady E Pocrnich
    Department of Ophthalmology, University of Western Ontario, Ivey Eye Institute, St Joseph s Hospital, 268 Grosvenor Street, London, ON, Canada
    Graefes Arch Clin Exp Ophthalmol 250:515-22. 2012
    ....
  40. pmc Human dermal fibroblasts derived from oculodentodigital dysplasia patients suggest that patients may have wound-healing defects
    Jared M Churko
    Department of Anatomy and Cell Biology, University of Western Ontario, London, ON, Canada
    Hum Mutat 32:456-66. 2011
    ..Collectively, our results suggest that ODDD patients may have subclinical defects in wound healing due to impaired function of dermal fibroblasts...
  41. ncbi request reprint Mechanisms of Cx43 and Cx26 transport to the plasma membrane and gap junction regeneration
    Tamsin Thomas
    Department of Anatomy and Cell Biology, University of Western Ontario, Dental Science Building, Rm 00077, London, Ontario, Canada N6A 5C1
    J Cell Sci 118:4451-62. 2005
    ....
  42. doi request reprint The protective effect of functional connexin43 channels on a human epithelial cell line exposed to oxidative stress
    Cindy M L Hutnik
    Department of Ophthalmology, University of Western Ontario, London, ON, Canada
    Invest Ophthalmol Vis Sci 49:800-6. 2008
    ..To determine the role of connexin43 (Cx43) and gap junctional intercellular communication (GJIC) in the response of the human retinal pigment epithelial cell line ARPE-19 to oxidative stress...
  43. pmc Loss of pannexin 1 attenuates melanoma progression by reversion to a melanocytic phenotype
    Silvia Penuela
    Department of Anatomy and Cell BiologyUniversity of Western Ontario, London, Ontario N6A 5C1, Canada
    J Biol Chem 287:29184-93. 2012
    ....
  44. doi request reprint Optical and biochemical dissection of connexin and disease-linked connexin mutants in 3D organotypic epidermis
    Stephanie Langlois
    Department of Anatomy and Cell Biology, University of Western Ontario, London, ON, Canada
    Methods Mol Biol 585:313-34. 2010
    ..The procedures necessary to assess the architectural characteristics of genetically modified organotypic epidermis and its state of differentiation will be described in this chapter...
  45. doi request reprint Ocular pathology relevant to glaucoma in a Gja1(Jrt/+) mouse model of human oculodentodigital dysplasia
    Edmund Tsui
    Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada
    Invest Ophthalmol Vis Sci 52:3539-47. 2011
    ..Hematoxylin and eosin (H&E)-stained eye sections were examined for ocular histopathology related to the development of glaucoma...
  46. ncbi request reprint Retroviral delivery of connexin genes to human breast tumor cells inhibits in vivo tumor growth by a mechanism that is independent of significant gap junctional intercellular communication
    Hong Qin
    Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Biol Chem 277:29132-8. 2002
    ..Moreover, our studies show that retroviruses are effective vehicles for delivering connexins to human breast tumor cells, facilitating potential gene therapy applications...
  47. ncbi request reprint Connexins and gap junctions in mammary gland development and breast cancer progression
    Elizabeth McLachlan
    Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada
    J Membr Biol 218:107-21. 2007
    ..In breast cancer, connexins generally act as tumor suppressors in the primary tumor; however, in advanced breast tumors, connexins appear to act as both context-dependent tumor suppressors and facilitators of disease progression...
  48. ncbi request reprint Oculodentodigital dysplasia-causing connexin43 mutants are non-functional and exhibit dominant effects on wild-type connexin43
    Wendi Roscoe
    Department of Physiology and Pharmacology and Anatomy, The University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Biol Chem 280:11458-66. 2005
    ....
  49. ncbi request reprint Connexin phosphorylation as a regulatory event linked to gap junction internalization and degradation
    Dale W Laird
    Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada N6A 5C1
    Biochim Biophys Acta 1711:172-82. 2005
    ..This paper will review the evidence that connexin phosphorylation regulates, stimulates or triggers gap junction disassembly, internalization and degradation...
  50. doi request reprint Myogenic bladder defects in mouse models of human oculodentodigital dysplasia
    Tao Huang
    Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada, N6A 5C1
    Biochem J 457:441-9. 2014
    ..Furthermore, although mutant mice have compromised smooth muscle contraction and response to stretch, overriding bladder defects in Cx43I130T mice are likely to be complemented by neurogenic changes. ..
  51. doi request reprint The biochemistry and function of pannexin channels
    Silvia Penuela
    Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada
    Biochim Biophys Acta 1828:15-22. 2013
    ..This article is part of a Special Issue entitled: The communicating junctions, roles and dysfunctions...
  52. doi request reprint Decreased levels of connexin43 result in impaired development of the mammary gland in a mouse model of oculodentodigital dysplasia
    Isabelle Plante
    Department of Anatomy and Cell Biology, Dental Science Building, University of Western Ontario, London, Ontario, Canada
    Dev Biol 318:312-22. 2008
    ..Together, these data revealed that decreased levels of Cx43 result in delayed development of the mammary gland and a full complement of Cx43 is necessary for the expulsion of milk...
  53. ncbi request reprint Transport and function of cx26 mutants involved in skin and deafness disorders
    Tamsin Thomas
    Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada
    Cell Commun Adhes 10:353-8. 2003
    ..Future experiments will examine the effect of the Cx26 mutants on the function and differentiation of these epidermal keratinocytes...
  54. doi request reprint Hypoxia and reoxygenation-induced oxidant production increase in microvascular endothelial cells depends on connexin40
    Guo Yu
    Lawson Health Research Institute, Critical Illness Research, London, ON, Canada
    Free Radic Biol Med 49:1008-13. 2010
    ..Together, the results raise an intriguing possibility that H/R-induced signaling in endothelial cells involves a cross-talk between Cx40 and NADPH oxidase...
  55. ncbi request reprint Beta3 integrins facilitate matrix interactions during transendothelial migration of PC3 prostate tumor cells
    Xiaowei Wang
    Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada
    Prostate 63:65-80. 2005
    ..We examined the role of beta3 integrins in TEM of PC3 human prostate cancer cells through a monolayer of human lung microvascular endothelial cells (HLMVECs)...
  56. ncbi request reprint A Gja1 missense mutation in a mouse model of oculodentodigital dysplasia
    Ann M Flenniken
    Centre for Modeling Human Disease, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    Development 132:4375-86. 2005
    ..Thus, these mice represent an experimental model with which to explore the clinical manifestations of ODDD and to evaluate potential intervention strategies...
  57. pmc Zebrafish early cardiac connexin, Cx36.7/Ecx, regulates myofibril orientation and heart morphogenesis by establishing Nkx2.5 expression
    Naznin Sultana
    Departments of Biological Sciences and Biological Information, Tokyo Institute of Technology, Yokohama 226 8501, Japan
    Proc Natl Acad Sci U S A 105:4763-8. 2008
    ..5 expression, which in turn promotes unidirectional, parallel alignment of myofibrils and the subsequent proper heart morphogenesis...
  58. ncbi request reprint A histone deacetylation-dependent mechanism for transcriptional repression of the gap junction gene cx43 in prostate cancer cells
    Maite Hernandez
    Departments of Medicine, Oncology, and Pharmacology and Therapeutics, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, McGill University, 3755 Chemin de la Cote Ste Catherine, Montreal, Quebec, Canada
    Prostate 66:1151-61. 2006
    ..cx43 is frequently downregulated in prostate cancer. We investigated the role of a histone deacetylase (HDAC)-dependent mechanism in the transcriptional repression of cx43 in a panel of prostate cancer cells...
  59. ncbi request reprint Multicolor and electron microscopic imaging of connexin trafficking
    Guido Gaietta
    National Center for Microscopy and Imaging Research, Department of Neurosciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Science 296:503-7. 2002
    ..Selective imaging by correlated optical and electron microscopy of protein molecules of known ages will clarify fundamental processes of protein trafficking in situ...
  60. ncbi request reprint Gap junctions assemble in the presence of cytoskeletal inhibitors, but enhanced assembly requires microtubules
    Ross G Johnson
    Department of Genetics, Cell Biology, and Development, University of Minnesota, St Paul, Minnesota 55108, USA
    Exp Cell Res 275:67-80. 2002
    ..However, microtubules are necessary for enhanced GJ growth and likely for facilitating connexin trafficking under basal conditions...