Paige Lacy

Summary

Affiliation: University of Alberta
Country: Canada

Publications

  1. pmc An essential role for Rab27a GTPase in eosinophil exocytosis
    John Dongil Kim
    2 559 HMRC, Department of Medicine, University of Alberta, Edmonton, AB, T6G 2S2, Canada
    J Leukoc Biol 94:1265-74. 2013
  2. pmc Agonist activation of f-actin-mediated eosinophil shape change and mediator release is dependent on Rac2
    Paige Lacy
    Pulmonary Research Group, Department of Medicine, University of Alberta, Edmonton, Alta, Canada
    Int Arch Allergy Immunol 156:137-47. 2011
  3. doi Cytokine release from innate immune cells: association with diverse membrane trafficking pathways
    Paige Lacy
    Pulmonary Research Group, Department of Medicine, University of Alberta, Edmonton, AB, Australia
    Blood 118:9-18. 2011
  4. ncbi Divergence of mechanisms regulating respiratory burst in blood and sputum eosinophils and neutrophils from atopic subjects
    Paige Lacy
    Pulmonary Research Group, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    J Immunol 170:2670-9. 2003
  5. pmc Mechanisms of degranulation in neutrophils
    Paige Lacy
    Pulmonary Research Group, Department of Medicine, University of Alberta, Edmonton, AB
    Allergy Asthma Clin Immunol 2:98-108. 2006
  6. ncbi Control of granule exocytosis in neutrophils
    Paige Lacy
    Pulmonary Research Group, Department of Medicine, University of Alberta, Edmonton, Canada
    Front Biosci 13:5559-70. 2008
  7. ncbi Neutrophil primary granule release and maximal superoxide generation depend on Rac2 in a common signalling pathway
    Dalia Abdel-Latif
    Pulmonary Research Group, Department of Medicine, University of Alberta, Edmonton, AB, Canada
    Can J Physiol Pharmacol 83:69-75. 2005
  8. pmc Regulation of inflammation by Rac2 in immune complex-mediated acute lung injury
    James L Dooley
    Dept of Medicine, Univ of Alberta, Edmonton, Canada
    Am J Physiol Lung Cell Mol Physiol 297:L1091-102. 2009
  9. ncbi Effects of clarithromycin on inflammatory cell mediator release and survival
    Peter D Borszcz
    Pulmonary Research Group, Department of Medicine, University of Alberta, Edmonton, Canada
    Chemotherapy 51:206-10. 2005
  10. pmc Primary granule exocytosis in human neutrophils is regulated by Rac-dependent actin remodeling
    Troy Mitchell
    Dept of Cell Biology, Univ of Alberta, Edmonton, Alberta, Canada T6G 2H7
    Am J Physiol Cell Physiol 295:C1354-65. 2008

Collaborators

Detail Information

Publications25

  1. pmc An essential role for Rab27a GTPase in eosinophil exocytosis
    John Dongil Kim
    2 559 HMRC, Department of Medicine, University of Alberta, Edmonton, AB, T6G 2S2, Canada
    J Leukoc Biol 94:1265-74. 2013
    ..These findings suggest that Rab27a has a key role in eosinophil degranulation. Furthermore, these findings have implications for Rab27a-dependent eosinophil degranulation in airway inflammation. ..
  2. pmc Agonist activation of f-actin-mediated eosinophil shape change and mediator release is dependent on Rac2
    Paige Lacy
    Pulmonary Research Group, Department of Medicine, University of Alberta, Edmonton, Alta, Canada
    Int Arch Allergy Immunol 156:137-47. 2011
    ..We set out to determine the role of Rac2 in eosinophil mediator release and F-actin-dependent shape change in response to chemotactic stimuli...
  3. doi Cytokine release from innate immune cells: association with diverse membrane trafficking pathways
    Paige Lacy
    Pulmonary Research Group, Department of Medicine, University of Alberta, Edmonton, AB, Australia
    Blood 118:9-18. 2011
    ..Surprisingly complex machinery, multiple organelles, and specialized membrane domains exist in these cells to ensure the selective, temporal, and often polarized release of cytokines in innate immunity...
  4. ncbi Divergence of mechanisms regulating respiratory burst in blood and sputum eosinophils and neutrophils from atopic subjects
    Paige Lacy
    Pulmonary Research Group, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    J Immunol 170:2670-9. 2003
    ..Our findings suggest that the differential modes of NADPH oxidase assembly in these cells may have important implications for oxidant-mediated tissue injury...
  5. pmc Mechanisms of degranulation in neutrophils
    Paige Lacy
    Pulmonary Research Group, Department of Medicine, University of Alberta, Edmonton, AB
    Allergy Asthma Clin Immunol 2:98-108. 2006
    ..This review focuses on new findings from the literature on the mechanisms that control the release of granule-derived mediators from neutrophils...
  6. ncbi Control of granule exocytosis in neutrophils
    Paige Lacy
    Pulmonary Research Group, Department of Medicine, University of Alberta, Edmonton, Canada
    Front Biosci 13:5559-70. 2008
    ..This review focuses on the understanding of distal molecular mechanisms controlling exocytosis from neutrophils...
  7. ncbi Neutrophil primary granule release and maximal superoxide generation depend on Rac2 in a common signalling pathway
    Dalia Abdel-Latif
    Pulmonary Research Group, Department of Medicine, University of Alberta, Edmonton, AB, Canada
    Can J Physiol Pharmacol 83:69-75. 2005
    ..These findings shed light on possible signalling mechanisms involved in granule secretion from activated neutrophils responding to different stimuli...
  8. pmc Regulation of inflammation by Rac2 in immune complex-mediated acute lung injury
    James L Dooley
    Dept of Medicine, Univ of Alberta, Edmonton, Canada
    Am J Physiol Lung Cell Mol Physiol 297:L1091-102. 2009
    ..We propose that lung injury in response to immune complex deposition is dependent on Rac2 in alveolar macrophages and neutrophils...
  9. ncbi Effects of clarithromycin on inflammatory cell mediator release and survival
    Peter D Borszcz
    Pulmonary Research Group, Department of Medicine, University of Alberta, Edmonton, Canada
    Chemotherapy 51:206-10. 2005
    ..The mode of anti-inflammatory effects of clarithromycin on inflammatory cells is not well understood. We hypothesized that clarithromycin inhibits inflammatory cell mediator release and survival...
  10. pmc Primary granule exocytosis in human neutrophils is regulated by Rac-dependent actin remodeling
    Troy Mitchell
    Dept of Cell Biology, Univ of Alberta, Edmonton, Alberta, Canada T6G 2H7
    Am J Physiol Cell Physiol 295:C1354-65. 2008
    ..Therefore, we propose a role for F-actin depolymerization at the cell cortex coupled with Rac-dependent F-actin polymerization in the cell cytoplasm to promote primary granule exocytosis...
  11. ncbi Mast cell tryptase activates peripheral blood eosinophils to release granule-associated enzymes
    Harissios Vliagoftis
    Pulmonary Research Group, Department of Medicine, University of Alberta, Edmonton, Alta, Canada
    Int Arch Allergy Immunol 135:196-204. 2004
    ..However, little is known about the effects of mast cell-specific mediators, such as tryptase, on eosinophils. Our objective was to investigate the effects of mast cell tryptase on human peripheral blood eosinophils...
  12. ncbi The role of Rho GTPases and SNAREs in mediator release from granulocytes
    Paige Lacy
    Pulmonary Research Group, 550A HMRC, Department of Medicine, University of Alberta, Edmonton, Canada, AB T6G 2S2
    Pharmacol Ther 107:358-76. 2005
    ..Together, these molecules link together to form a common signaling pathway for mediator release from granulocytes. Identifying these molecules and their function may provide novel targets for the prevention of inflammatory reactions...
  13. ncbi Rac2 is critical for neutrophil primary granule exocytosis
    Dalia Abdel-Latif
    Pulmonary Research Group and the Canadian Institutes of Health Research Group on Molecular and Cell Biology of Lipids, Department of Medicine, University of Alberta, Edmonton, AB, Canada
    Blood 104:832-9. 2004
    ..These findings suggest an obligatory role for Rac2 in regulation of primary granule release by neutrophils...
  14. pmc Proteomic analysis of secretagogue-stimulated neutrophils implicates a role for actin and actin-interacting proteins in Rac2-mediated granule exocytosis
    Gary Eitzen
    Department of Cell Biology, University of Alberta, Edmonton, AB, Canada
    Proteome Sci 9:70. 2011
    ..abstract:..
  15. ncbi NMR analysis of neutrophil activation in sputum samples from patients with cystic fibrosis
    Erik J Saude
    CIHR Group in Protein Structure and Function, Department of Biochemistry, University of Alberta, Alberta, Canada
    Magn Reson Med 52:807-14. 2004
    ..869). Our findings indicate that neutrophil and eosinophil activation in CF is detectable by NMR. NMR may be a useful tool for the detection of biological markers of inflammatory processes in patient airways...
  16. ncbi Eosinophil function in allergic inflammation: from bone marrow to tissue response
    Darryl Adamko
    Department of Medicine, 550A HMRC, University of Alberta, Edmonton, AB T6G 2S2, Canada
    Curr Allergy Asthma Rep 4:149-58. 2004
    ..In this review, we examine the pathways associated with eosinophil recruitment and activation, and discuss these findings with reference to clinically defined categories...
  17. ncbi Mechanisms of eosinophil recruitment and activation
    Darryl Adamko
    Department of Medicine, University of Alberta, 550A HMRC, Edmonton, AB T6G 2S2, Canada
    Curr Allergy Asthma Rep 2:107-16. 2002
    ..This review examines the pathways associated with eosinophil recruitment and activation and discusses these findings, with reference to clinically defined categories...
  18. ncbi Expression of eosinophil target SNAREs as potential cognate receptors for vesicle-associated membrane protein-2 in exocytosis
    Michael R Logan
    Pulmonary Research Group, Department of Medicine, University of Alberta, Edmonton, Canada
    J Allergy Clin Immunol 109:299-306. 2002
    ....
  19. ncbi The induction of eosinophil peroxidase release: improved methods of measurement and stimulation
    Darryl J Adamko
    The Pulmonary Research Group, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    J Immunol Methods 291:101-8. 2004
    ..Finally, using this technique, we have been able to demonstrate secretory IgA (s-IgA)-induced release of EPO. By using OPD, we have developed a more sensitive and specific method to analyze the release of extracellular EPO...
  20. ncbi Vesicle-associated membrane protein 7 (VAMP-7) is essential for target cell killing in a natural killer cell line
    Marcelo Marcet-Palacios
    Pulmonary Research Group, Department of Medicine, University of Alberta, 550A Heritage Medical Research Centre, Edmonton, Alta, Canada
    Biochem Biophys Res Commun 366:617-23. 2008
    ..Thus, targeting VAMP-7 expression specifically with siRNA, following transplantation, may be a viable strategy for preventing NK cell-mediated transplant rejection, in vivo...
  21. doi Streptococcus pneumoniae and Staphylococcus aureus pneumonia induce distinct metabolic responses
    Carolyn M Slupsky
    Department of Medicine, and Magnetic Resonance Diagnostics Centre, 550A HMRC, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
    J Proteome Res 8:3029-36. 2009
    ..These results underline the potential of metabolomics as a tool for diagnosis, health monitoring, and drug development, and show its usefulness for understanding microbial-host interactions...
  22. pmc Anaplasma phagocytophilum utilizes multiple host evasion mechanisms to thwart NADPH oxidase-mediated killing during neutrophil infection
    Jason A Carlyon
    Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Infect Immun 72:4772-83. 2004
    ..Once internalized, the bacterium resides within a protective vacuole that excludes p22(phox) and gp91(phox). Thus, A. phagocytophilum employs at least two strategies to protect itself from neutrophil NADPH oxidase-mediated killing...
  23. doi Eosinophils: biological properties and role in health and disease
    Simon P Hogan
    Clin Exp Allergy 38:709-50. 2008
    ..Finally, strategies for targeted therapeutic intervention in eosinophil-mediated mucosal diseases are conceptualized...
  24. ncbi Effects of fluticasone on systemic markers of inflammation in chronic obstructive pulmonary disease
    Don D Sin
    James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada
    Am J Respir Crit Care Med 170:760-5. 2004
    ..Inhaled and oral corticosteroids are effective in reducing serum CRP levels in patients with COPD and suggest their potential use for improving cardiovascular outcomes in COPD...
  25. ncbi Human eosinophils express and release IL-13 following CD28-dependent activation
    Gaetane Woerly
    Centre d Immunologie et Biologie Parasitaire, Unité INSERM U547 and IFR17, Institut Pasteur, Lille, France
    J Leukoc Biol 72:769-79. 2002
    ..By having the capacity to synthesize and release IL-13, eosinophils may participate in the development and maintenance of the T helper cell type 2 response, a prominent feature of allergic diseases...