Affiliation: University of Ottawa
- The right profile: mismatch negativity in schizophrenia with and without auditory hallucinations as measured by a multi-feature paradigmDerek J Fisher
Department of Psychology Institute of Neuroscience, Carleton University, Ottawa, Ont, Canada
Clin Neurophysiol 119:909-21. 2008..To examine pre-attentive acoustic change detection in schizophrenia patients with and without auditory hallucinations via mismatch negativity (MMN) extracted from a multi-feature paradigm...
- Evidence review and clinical guidance for the use of ziprasidone in CanadaDavid M Gardner
Department of Psychiatry, Dalhousie University, Halifax, NS, Canada
Ann Gen Psychiatry 12:1. 2013..Key challenges in practice include the need for dosing on a full stomach and managing its early onset adverse effect of restlessness. Addressing these issues are critical to its long-term success...
- Association study of the trinucleotide repeat polymorphism within SMARCA2 and schizophreniaSarojini Sengupta
Department of Human Genetics, McGill University, Montreal, Canada
BMC Genet 7:34. 2006....
- Retention rates in placebo- and nonplacebo-controlled clinical trials of schizophreniaA Labelle
University of Ottawa, Ontario
Can J Psychiatry 44:887-92. 1999..To determine if the inclusion of a placebo control in clinical trials of schizophrenia affects retention rates in the first 35 days of inclusion relative to trials that did not have a placebo control...
- Risperidone treatment of outpatients with schizophrenia: no evidence of sex differences in treatment responseA Labelle
Schizophrenia Program, Royal Ottawa Hospital, Ottawa, Ontario
Can J Psychiatry 46:534-41. 2001....
- Switching outpatients with schizophrenia and related disorders on long-acting injectable antipsychotics to olanzapine: an open-label naturalistic pilot studyAlain Labelle
University of Ottawa, Psychology, Carleton University, Ottawa, Ontario, Canada
J Clin Psychopharmacol 22:545-53. 2002..These results should be considered preliminary and require replication using appropriate control groups...
- Event-related potentials in schizophrenic patients during a degraded stimulus version of the visual continuous performance taskV Knott
Department of Psychiatry, University of Ottawa Royal Ottawa Hospital, Ontario, Canada
Schizophr Res 35:263-78. 1999..The implications of these findings are described in relation to attentional disturbances and trait versus state issues in schizophrenics...
- The treatment of negative symptoms: a clinical and methodological studyY D Lapierre
Department of Psychiatry, Royal Ottawa Hospital, Ontario, Canada
Int Clin Psychopharmacol 14:101-12. 1999..In addition, the design of the study provides a methodology that is appropriate to the study of primary negative symptoms in schizophrenia...
- Quantitative EEG in schizophrenia and in response to acute and chronic clozapine treatmentV Knott
Department of Psychiatry and Psychology, University of Ottawa and Institute of Mental Health Research, Royal Ottawa Hospital, 1145 Carling Avenue, Ottawa, Ont, Canada K1Z 7K4
Schizophr Res 50:41-53. 2001..The preliminary findings suggest that brain electric profiling may be a promising tool for assessing and understanding the central impact of pharmacotherapeutic interventions in schizophrenia...
- Double-blind, placebo-controlled comparison of the efficacy of sertraline as treatment for a major depressive episode in patients with remitted schizophreniaDonald Addington
Departments of Psychiatry, University of Calgary, Calgary, Alberta, Canada
J Clin Psychopharmacol 22:20-5. 2002..Testing the efficacy of widely accepted but poorly evaluated treatments should be a research priority. Future studies require a larger sample size and longer duration of treatment...
- Monthly administration of long-acting injectable risperidone and striatal dopamine D2 receptor occupancy for the management of schizophreniaHiroyuki Uchida
Centre for Addiction and Mental Health, Toronto, Ontario, Canada
J Clin Psychiatry 69:1281-6. 2008..The objective of this positron emission tomography (PET) study was to examine the striatal dopamine D(2) binding of long-acting risperidone administered intramuscularly once a month...
- Dissociating medication effects from learning and practice effects in a neurocognitive study of schizophrenia: Olanzapine versus haloperidolLuc J Boulay
University of Ottawa Institute of Mental Health Research, Royal Ottawa Hospital Ottawa, Ontario Canada
Cogn Neuropsychiatry 12:322-38. 2007..To contrast the effect of a typical antipsychotic (haloperidol) and an atypical antipsychotic (olanzapine) on neurocognitive functioning in schizophrenia when learning and practice (LP) effects are controlled...
- A PET study evaluating dopamine D2 receptor occupancy for long-acting injectable risperidoneGary Remington
Schizophrenia Program, Centre for Addiction and Mental Health, Toronto, Ont M5T 1R8, Canada
Am J Psychiatry 163:396-401. 2006..The present study used positron emission tomography (PET) to evaluate its dopamine D(2) binding profile at doses of 25, 50, or 75 mg administered every 2 weeks...
- Increased prevalence of schizophrenia spectrum disorders in relatives of neuroleptic-nonresponsive schizophrenic patientsRidha Joober
Douglas Hospital Research Center, Douglas Hospital, Verdun, Quebec, Canada
Schizophr Res 77:35-41. 2005..In order to test this hypothesis, we compared the pattern of familial aggregation of schizophrenia related disorders in schizophrenic patients who are either responders (R) or nonresponders (NR) to typical neuroleptics...
- Neuropsychological impairments in neuroleptic-responder vs. -nonresponder schizophrenic patients and healthy volunteersRidha Joober
Douglas Hospital Research Center, McGill University, Que, H3A 1A1, Montreal, Canada
Schizophr Res 53:229-38. 2002....
- Catechol-O-methyltransferase Val-108/158-Met gene variants associated with performance on the Wisconsin Card Sorting TestRidha Joober
Arch Gen Psychiatry 59:662-3. 2002
- EEG coherence following acute and chronic clozapine in treatment-resistant schizophrenicsVerner J Knott
Department of Psychiatry and Psychology, University of Ottawa Royal Ottawa Hospital, Ontario, Canada
Exp Clin Psychopharmacol 10:435-44. 2002..Findings are discussed in relation to "disconnection" theories of schizophrenia...
- CAA insertion polymorphism in the 3'UTR of Nogo gene on 2p14 is not associated with schizophreniaLan Xiong
Department of Psychiatry, Douglas Hospital Research Centre, 6875 Boulevard LaSalle, FBC Pavillion, Verdun, Quebec, Canada H4H1R3
Brain Res Mol Brain Res 133:153-6. 2005..0% vs. 15.0%, chi2=0.985, p>0.1). Furthermore, neither CAAins/TATCdel individually, nor the haplotype carrying both CAAins and TATCdel is preferentially transmitted to affected offspring...
- Dopamine beta-hydroxylase (DBH) gene and schizophrenia phenotypic variability: a genetic association studyKenji Yamamoto
Douglas Hospital Research Centre 6875 Boulevard LaSalle, Verdun H4H 1R3, Canada
Am J Med Genet B Neuropsychiatr Genet 117:33-8. 2003..These results suggest that the DBH gene is not a causative factor in schizophrenia but that it may be a modulator of psychotic symptoms, severity of the disorder and therapeutic response to neuroleptic drugs...