Research Topics
| Deepali KumarSummaryAffiliation: University of Alberta Country: Canada Publications
| Collaborators
|
Detail Information
Publications
Emerging viruses in transplantationDeepali Kumar
Transplant Infectious Diseases, University of Alberta, Edmonton, Alberta, Canada
Curr Opin Infect Dis 23:374-8. 2010..Several viruses have recently gained importance for the transplant recipient. The purpose of this review is to give an update on emerging viruses in transplantation...- Respiratory viral infections in transplant and oncology patientsDeepali Kumar
Department of Medicine, Transplant Infectious Diseases, University of Alberta, 6 030 Katz Rexall Center for Health Research, Edmonton, Alberta T6G 2E1, Canada
Infect Dis Clin North Am 24:395-412. 2010..This article describes the current knowledge about respiratory viral infections as it relates to solid organ transplant, hematopoietic stem cell transplant, and oncology settings... - A randomized, double-blind trial of pneumococcal vaccination in adult allogeneic stem cell transplant donors and recipientsDeepali Kumar
Transplant Infectious Diseases, University of Alberta, Edmonton, Alberta, Canada
Clin Infect Dis 45:1576-82. 2007..Pneumococcal conjugate vaccine (PCV7) may improve immunogenicity in this population, and a donor vaccination strategy may benefit patients undergoing HSCT... - A randomized, double-blind, placebo-controlled trial to evaluate the prime-boost strategy for pneumococcal vaccination in adult liver transplant recipientsDeepali Kumar
Transplant Infectious Diseases, University of Alberta, Edmonton, Canada
Clin Infect Dis 47:885-92. 2008..It may be possible to enhance immunogenicity by priming the recipient with the 7-valent pneumococcal conjugate vaccine (PCV7), followed by boosting with PPV23... - Invasive pneumococcal disease in adult hematopoietic stem cell transplant recipients: a decade of prospective population-based surveillanceD Kumar
Division of Infectious Diseases, University of Alberta, Edmonton, Alberta, Canada
Bone Marrow Transplant 41:743-7. 2008..The antimicrobial resistance rates were high, especially for trimethoprim/sulfamethoxazole. HSCT recipients are at significantly greater risk for IPD than the general population. Preventative strategies are necessary... - Pneumocystis jirovecii pneumonia after rituximab therapy for antibody-mediated rejection in a renal transplant recipientD Kumar
Transplant Infectious Diseases, Division of Infectious Diseases, University of Alberta, Edmonton, Alberta, Canada
Transpl Infect Dis 11:167-70. 2009..After therapy with rituximab, she developed Pneumocystis jirovecii pneumonia (PJP) requiring hospitalization. We discuss the increasing literature for the use of rituximab for AMR and the need for PJP prophylaxis in this setting... - Influenza vaccination in the organ transplant recipient: review and summary recommendationsD Kumar
Transplant Infectious Diseases, University of Alberta, Edmonton, AB, Canada Division of Infectious Diseases, University of Pennsylvania, Philadelphia, PA, USA
Am J Transplant 11:2020-30. 2011..In this document, we review the current state of knowledge on influenza vaccines in transplant recipients and make recommendations on the use of vaccine in both adult and pediatric organ transplant recipients... - A prospective molecular surveillance study evaluating the clinical impact of community-acquired respiratory viruses in lung transplant recipientsDeepali Kumar
Transplant Infectious Diseases, University of Alberta, Edmonton, Alberta, Canada
Transplantation 89:1028-33. 2010..The use of sensitive molecular methods that can simultaneously detect a large panel of respiratory viruses may help better define their effects... 
Outcomes from pandemic influenza A H1N1 infection in recipients of solid-organ transplants: a multicentre cohort studyDeepali Kumar
University of Alberta, Edmonton, AB, Canada
Lancet Infect Dis 10:521-6. 2010..We aimed to establish the outcomes of pandemic influenza A H1N1 and factors leading to severe disease in a cohort of patients who had received transplants...- Cell-mediated immunity to predict cytomegalovirus disease in high-risk solid organ transplant recipientsD Kumar
Transplant Infectious Diseases, University of Alberta, Edmonton, Alberta, Canada
Am J Transplant 9:1214-22. 2009..0%) patients with a detectable interferon-gamma response (cutoff 0.1 IU/mL) versus 10/25 (40.0%) patients with a negative CMI, p = 0.12. Monitoring of CMI may be useful for predicting late-onset CMV disease... - Lack of association between beta-herpesvirus infection and bronchiolitis obliterans syndrome in lung transplant recipients in the era of antiviral prophylaxisOriol Manuel
Transplant Infectious Diseases, University of Alberta, Edmonton, AB, Canada
Transplantation 87:719-25. 2009..We assessed the contribution of these viruses in the development of bronchiolitis obliterans syndrome (BOS) after lung transplantation... - The clinical utility of whole blood versus plasma cytomegalovirus viral load assays for monitoring therapeutic responseLuiz F Lisboa
Department of Medicine, University of Alberta, Edmonton, AB, Canada
Transplantation 91:231-6. 2011..We compared a whole blood real-time PCR with a plasma PCR assay for monitoring therapeutic response... - An analysis of regulatory T-cell and Th-17 cell dynamics during cytomegalovirus replication in solid organ transplant recipientsAdrian Egli
Alberta Transplant Institute and Li Ka Shing Institute of Virology, University of Alberta, Edmonton, Alberta, Canada
PLoS ONE 7:e43937. 2012..However, T-cell subsets such as T-regs and IL-17 producing T-cells (Th-17) are not well studied in this context. We explored T-regs and Th-17 frequencies during CMV-replication after transplantation... - Impact of genetic polymorphisms in cytomegalovirus glycoprotein B on outcomes in solid-organ transplant recipients with cytomegalovirus diseaseOriol Manuel
Transplant Infectious Diseases and Provincial Laboratory for Public Health Microbiology, University of Alberta, Edmonton, Alberta, Canada
Clin Infect Dis 49:1160-6. 2009..Polymorphisms in the CMV glycoprotein B (gB) gene allow discrimination of 4 distinct genotypes (gB1-gB4). We assessed the influence of gB genotypes on the clinical and virologic outcome of CMV disease... - Clinical utility of molecular surveillance for cytomegalovirus after antiviral prophylaxis in high-risk solid organ transplant recipientsLuiz F Lisboa
Transplant Infectious Diseases, University of Alberta, Edmonton, AB, Canada
Transplantation 92:1063-8. 2011..Virologic monitoring after prophylaxis has been proposed as a way to prevent late-onset disease... - Clinical utility of cytomegalovirus cell-mediated immunity in transplant recipients with cytomegalovirus viremiaLuiz F Lisboa
Transplant Infectious Diseases, Department of Medicine, University of Alberta, Edmonton, Canada
Transplantation 93:195-200. 2012..A CD8+ T-cell response to cytomegalovirus (CMV) has been associated with control of viral replication. Assessment shortly after the onset of asymptomatic viremia could help significantly refine preemptive strategies... - Incidence and clinical characteristics of herpes zoster after lung transplantationOriol Manuel
Department of Transplant Infectious Diseases, University of Alberta, Edmonton, Alberta, Canada
J Heart Lung Transplant 27:11-6. 2008..Epidemiologic data in lung transplant recipients are lacking. We determined the incidence and clinical characteristics of herpes zoster, and the risk factors for developing herpes zoster, after lung transplantation... - An assessment of donor-to-recipient transmission patterns of human cytomegalovirus by analysis of viral genomic variantsOriol Manuel
Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
J Infect Dis 199:1621-8. 2009..We studied human cytomegalovirus (CMV) donor-to-recipient transmission patterns in organ transplantation by analyzing genomic variants on the basis of CMV glycoprotein B (gB) genotyping... 
Cytomegalovirus (CMV) glycoprotein B genotypes and response to antiviral therapy, in solid-organ-transplant recipients with CMV diseaseAtul Humar
Department of Medicine, Division of Multi Organ Transplantation, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
J Infect Dis 188:581-4. 2003..It appears that the gB genotype, which causes CMV disease, does not significantly influence CMV-load kinetics or clinical response to therapy...- Cytomegalovirus (CMV) virus load kinetics to predict recurrent disease in solid-organ transplant patients with CMV diseaseAtul Humar
Department of Medicine, Division of Infectious Diseases and Multi Organ Transplantation, Toronto, Canada
J Infect Dis 186:829-33. 2002..17 days among patients without recurrence (P=.001). This was not explainable by detectable ganciclovir resistance. CMV load kinetics are useful for identifying, at a very early stage, patients who are more likely to have recurrence... - Emergence of Aspergillus calidoustus infection in the era of posttransplantation azole prophylaxisAdrian Egli
Transplant Infectious Diseases, University of Alberta, Edmonton, Alberta, Canada
Transplantation 94:403-10. 2012..We noted an increase in isolates of Aspergillus calidoustus in our transplant population and hypothesized that increasing azole use (universal prophylaxis since 2008) may be promoting this infection... - Assessment of adenovirus infection in adult lung transplant recipients using molecular surveillanceAtul Humar
Department of Medicine, University of Toronto, Toronto, Ontario, Canada
J Heart Lung Transplant 25:1441-6. 2006..Little is known about adenovirus infections in adult lung transplant recipients. Because the virus can establish latency, re-activation may be relatively common after transplantation... - An international survey of cytomegalovirus management practices in lung transplantationDalyce M Zuk
Lung Transplant Program, University of Alberta, Edmonton, Alberta, Canada
Transplantation 90:672-6. 2010..Cytomegalovirus (CMV) is an important infection in lung transplant recipients. Center-to-center variation in preventive and treatment strategies is unknown... - Methicillin-resistant Staphylococcus aureus infection after lung transplantation: 5-year review of clinical and molecular epidemiologyOriol Manuel
Transplant Infectious Diseases, University of Alberta, Edmonton, Alberta, Canada
J Heart Lung Transplant 28:1231-6. 2009..Data on the epidemiology of MRSA infection in lung transplantation is limited... - Early post-transplant vaccination with pandemic influenza A/H1N1 vaccine in pediatric heart transplant recipientsLuis Altamirano-Diaz
Pediatric Heart Transplant, Stollery Children s Hospital, Transplant Infectious Diseases, University of Alberta, Edmonton, AB, Canada
Pediatr Transplant 15:172-5. 2011..Three of five developed protective titers against H1N1. A proportion of pediatric patients may respond to influenza vaccine even when immunized in the early post-transplant period... - Interactions between cytomegalovirus, human herpesvirus-6, and the recurrence of hepatitis C after liver transplantationAtul Humar
Department of Medicine, Multi Organ Transplantation, Toronto General Hospital, University Health Network, Department of Microbiology, University of Toronto, Toronto, Canada
Am J Transplant 2:461-6. 2002..031). In conclusion, HHV-6 and CMV infection and viral load were not associated with increased overall rates of HCV recurrence or HCV viral load after liver transplantation but may be associated with more severe forms of recurrence... - Humoral immune response following seasonal influenza vaccine in islet transplant recipientsMoacyr Silva
Alberta Transplant Institute, University of Alberta, Edmonton, Alberta, Canada
Cell Transplant 22:469-76. 2013..Novel strategies for protection in this group of patients need further study... - Long term immune responses to pandemic influenza A/H1N1 infection in solid organ transplant recipientsAliyah Baluch
Alberta Institute of Transplant Sciences, University of Alberta, Edmonton, Alberta, Canada
PLoS ONE 6:e28627. 2011..We show that a substantial proportion of SOT recipients with previous pH1N1 infection lack long-term humoral and cellular immune responses to pH1N1. These patients most likely are at risk for re-infection... - Guidance on novel influenza A/H1N1 in solid organ transplant recipientsD Kumar
Transplant Infectious Diseases, University of Alberta, Edmonton, Alberta, Canada
Am J Transplant 10:18-25. 2010..As new information emerges about novel H1N1, updates will be made to the electronic version of the document posted on the websites of the AST and TTS... - An assessment of herpesvirus co-infections in patients with CMV disease: correlation with clinical and virologic outcomesA Humar
Department of Medicine, University of Alberta, Edmonton, AB, Canada
Am J Transplant 9:374-81. 2009..Routine monitoring for viral co-infection in patients with CMV disease is not indicated... - Comparison of the effect of standard and novel immunosuppressive drugs on CMV-specific T-cell cytokine profilingAdrian Egli
Alberta Transplant Institute, University of Alberta, Edmonton, Alberta, Canada
Transplantation 95:448-55. 2013..We assessed the in vitro effects of individual standard and novel immunosuppressive drugs on a broad range of CMV-specific T-cell responses... - Graphium basitruncatum fungemia in a patient with acute leukemiaDeepali Kumar
Division of Infectious Diseases, University of Toronto, Ontario, Canada
J Clin Microbiol 45:1644-7. 2007..basitruncatum, a member of the Microascaceae, is phylogenetically and morphologically distinct from Graphium penicillioides and the opportunistic pathogens Scedosporium apiospermum (Pseudallescheria boydii) and Scedosporium prolificans... - State-of-the-Art Monitoring of Cytomegalovirus-Specific Cell-Mediated Immunity After Organ Transplant: A Primer for the ClinicianAdrian Egli
Transplant Infectious Diseases, Alberta Transplant Institute, University of Alberta, Edmonton, Canada
Clin Infect Dis 55:1678-89. 2012..In this review, we discuss the measurement of CMV-specific T-cell responses and their clinical impact on the management of CMV after organ transplantation... - Emerging viral infections in transplant recipientsDeepali Kumar
Transplant Infectious Diseases, University of Toronto, Toronto, Ontario, Canada
Curr Opin Infect Dis 18:337-41. 2005..Lessons learned from West Nile virus and severe acute respiratory syndrome in transplantation should be applicable to future outbreaks of other emerging infectious diseases... - Immunogenicity and safety of an intradermal boosting strategy for vaccination against influenza in lung transplant recipientsO Manuel
Transplant Infectious Diseases, University of Alberta, Edmonton, Alberta, Canada
Am J Transplant 7:2567-72. 2007..024). After a single standard dose of influenza vaccine, a booster dose given by intradermal injection did not significantly improve vaccine immunogenicity in lung transplant recipients... - QuantiFERON-TB Gold assay for the diagnosis of latent tuberculosis infectionOriol Manuel
Provincial Laboratory for Public Health Microbiology, University of Alberta Hospital, WMC 2B4 57, 8440 122 Street, Edmonton, AB, Canada
Expert Rev Mol Diagn 8:247-56. 2008..In contrast to TST, there are no prospective studies regarding the association of the QFT-G result and the risk for development of TB. Given its advantages, the QFT-G may become the standard test for the diagnosis of LTBI... - Comparison of quantiferon-TB gold with tuberculin skin test for detecting latent tuberculosis infection prior to liver transplantationO Manuel
Transplant Infectious Diseases, and Microbiology, University of Alberta, Edmonton, Alberta, Canada
Am J Transplant 7:2797-801. 2007..In patients awaiting liver transplantation, both the TST and QFT-G were comparable for the diagnosis of LTBI with reasonable concordance between tests. Indeterminate QFT-G result was more likely in those with more advanced liver disease... - Randomized, double-blind, controlled trial of pneumococcal vaccination in renal transplant recipientsDeepali Kumar
The Immunocompromised Host Infection Service, Division of Multi Organ Transplant and Infectious Diseases, University of Toronto, Toronto, Canada
J Infect Dis 187:1639-45. 2003..09). The response rate and mean fold increase in OPA titers were not significantly different between groups. There was a trend toward enhanced immunogenicity for PCV7 by ELISA. However, functional antibody responses were not different... - Anidulafungin versus fluconazole for invasive candidiasisAnnette C Reboli
University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School and Cooper University Hospital, Camden, NJ 08103, USA
N Engl J Med 356:2472-82. 2007..Anidulafungin, a new echinocandin, has potent activity against candida species. We compared anidulafungin with fluconazole in a randomized, double-blind, noninferiority trial of treatment for invasive candidiasis... - A surveillance study of adenovirus infection in adult solid organ transplant recipientsAtul Humar
University of Toronto, Toronto, Ontario, Canada
Am J Transplant 5:2555-9. 2005..No serious clinical sequelae or effects on subsequent acute rejection were observed... - Community-acquired West Nile virus infection in solid-organ transplant recipientsDeepali Kumar
The Immunocompromised Host Infection Service, Multi organ Transplant and Infectious Diseases, University of Toronto, Toronto, Ontario, Canada
Transplantation 77:399-402. 2004..During 2002, an outbreak of WNV occurred in Toronto, Canada. We observed four cases of severe symptomatic community-acquired WNV infection in our organ-transplant population...