Affiliation: University of Ottawa
Busca A, Konarski Y, Gajanayaka N, O Hara S, Angel J, Kozlowski M, et al
. cIAP1/2-TRAF2-SHP-1-Src-MyD88 Complex Regulates Lipopolysaccharide-Induced IL-27 Production through NF-ÎºB Activation in Human Macrophages. J Immunol. 2018;200:1593-1606 pubmed publisher
..These signaling pathways may constitute novel therapeutic avenues for immune modulation of IL-27 and provide insight into the modulatory immune effects of SMM. ..
Busca A, Saxena M, Iqbal S, Angel J, Kumar A. PI3K/Akt regulates survival during differentiation of human macrophages by maintaining NF-?B-dependent expression of antiapoptotic Bcl-xL. J Leukoc Biol. 2014;96:1011-22 pubmed publisher
..Our results also suggest new, potential therapeutic targets to modulate differentiation and survival of this cell type. ..
Saxena M, Busca A, Holcik M, Kumar A. Bacterial DNA Protects Monocytic Cells against HIV-Vpr-Induced Mitochondrial Membrane Depolarization. J Immunol. 2016;196:3754-67 pubmed publisher
..Thus, c-IAP-2 may prevent Vpr-mediated mitochondrial depolarization through stabilizing TRAF-1/2 expression and sequential inhibition of caspase-8, Bid, and Bax. ..
Sirskyj D, Kumar A, Azizi A. Mechanisms Underlying the Immune Response Generated by an Oral Vibrio cholerae Vaccine. Int J Mol Sci. 2016;17: pubmed publisher
..Determining the critical signaling pathways involved in the induction of immune response to this vaccine would be beneficial, and could contribute to more precisely-designed versions of other oral vaccines in the future. ..
Gajanayaka N, O Hara S, Konarski Y, Fernandes J, Muthumani K, Kozlowski M, et al
. HIV and HIV-Tat inhibit LPS-induced IL-27 production in human macrophages by distinct intracellular signaling pathways. J Leukoc Biol. 2017;102:925-939 pubmed publisher