Murray D Krahn

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. doi request reprint A reference set of health utilities for long-term survivors of prostate cancer: population-based data from Ontario, Canada
    Murray D Krahn
    Department of Medicine, University of Toronto, Toronto, Canada
    Qual Life Res 22:2951-62. 2013
  2. pmc Specialized multi-disciplinary heart failure clinics in Ontario, Canada: an environmental scan
    Harindra C Wijeysundera
    Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, Ontario, Canada
    BMC Health Serv Res 12:236. 2012
  3. pmc Understanding the role of scientific evidence in consumer evaluation of natural health products for osteoarthritis an application of the means end chain approach
    Teresa Tsui
    University of Toronto, Toronto, ON, Canada
    BMC Complement Altern Med 12:198. 2012
  4. pmc Health-state utilities in a prisoner population: a cross-sectional survey
    Christopher A K Y Chong
    Section of General Internal Medicine, Lakeridge Health Oshawa, Canada
    Health Qual Life Outcomes 7:78. 2009
  5. doi request reprint The next step in guideline development: incorporating patient preferences
    Murray Krahn
    Toronto Health Economics and Technology Assessment Collaborative, Toronto General Research Institute, and University of Toronto, Toronto, Ontario, Canada
    JAMA 300:436-8. 2008
  6. doi request reprint Healthcare costs associated with prostate cancer: estimates from a population-based study
    Murray D Krahn
    Department of Medicine, University of Toronto, Toronto, Canada
    BJU Int 105:338-46. 2010
  7. ncbi request reprint 30-day mortality and major complications after radical prostatectomy: influence of age and comorbidity
    Shabbir M H Alibhai
    Division of General Internal Medicine and Clinical Epidemiology, University Health Network, Toronto, Canada
    J Natl Cancer Inst 97:1525-32. 2005
  8. doi request reprint Health care costs associated with hepatocellular carcinoma: a population-based study
    Hla Hla Thein
    Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada Ontario Institute for Cancer Research Cancer Care Ontario, Toronto, Ontario, Canada
    Hepatology 58:1375-84. 2013
  9. ncbi request reprint Do older men benefit from curative therapy of localized prostate cancer?
    Shabbir M H Alibhai
    University Health Network, Room ENG 233, 200 Elizabeth St, Toronto, Ontario, Canada M5G 2C4
    J Clin Oncol 21:3318-27. 2003
  10. doi request reprint Is there an optimal comorbidity index for prostate cancer?
    Shabbir M H Alibhai
    Division of General Internal Medicine and Clinical Epidemiology, University Health Network, Toronto, Ontario, Canada
    Cancer 112:1043-50. 2008

Detail Information

Publications72

  1. doi request reprint A reference set of health utilities for long-term survivors of prostate cancer: population-based data from Ontario, Canada
    Murray D Krahn
    Department of Medicine, University of Toronto, Toronto, Canada
    Qual Life Res 22:2951-62. 2013
    ..To measure quality of life (QOL) and utilities for prostate cancer (PC) patients and determine their predictors...
  2. pmc Specialized multi-disciplinary heart failure clinics in Ontario, Canada: an environmental scan
    Harindra C Wijeysundera
    Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, Ontario, Canada
    BMC Health Serv Res 12:236. 2012
    ..Also, the service models of current clinics have not been described. It is therefore uncertain whether the efficacy of HF clinics in trials is generalizable to the HF clinics currently operating in the province...
  3. pmc Understanding the role of scientific evidence in consumer evaluation of natural health products for osteoarthritis an application of the means end chain approach
    Teresa Tsui
    University of Toronto, Toronto, ON, Canada
    BMC Complement Altern Med 12:198. 2012
    ..The primary objective was to investigate how the level of scientific evidence supporting the efficacy of NHPs impacts consumer decision-making in the self-selection of NHPs by individuals with osteoarthritis...
  4. pmc Health-state utilities in a prisoner population: a cross-sectional survey
    Christopher A K Y Chong
    Section of General Internal Medicine, Lakeridge Health Oshawa, Canada
    Health Qual Life Outcomes 7:78. 2009
    ..Health-state utilities for prisoners have not been described...
  5. doi request reprint The next step in guideline development: incorporating patient preferences
    Murray Krahn
    Toronto Health Economics and Technology Assessment Collaborative, Toronto General Research Institute, and University of Toronto, Toronto, Ontario, Canada
    JAMA 300:436-8. 2008
  6. doi request reprint Healthcare costs associated with prostate cancer: estimates from a population-based study
    Murray D Krahn
    Department of Medicine, University of Toronto, Toronto, Canada
    BJU Int 105:338-46. 2010
    ..Health Economic (multiway sensitivity analyses)...
  7. ncbi request reprint 30-day mortality and major complications after radical prostatectomy: influence of age and comorbidity
    Shabbir M H Alibhai
    Division of General Internal Medicine and Clinical Epidemiology, University Health Network, Toronto, Canada
    J Natl Cancer Inst 97:1525-32. 2005
    ..Prior studies have suggested an increased risk of short-term complications among older men who underwent radical prostatectomy, but these studies did not adjust for comorbidity...
  8. doi request reprint Health care costs associated with hepatocellular carcinoma: a population-based study
    Hla Hla Thein
    Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada Ontario Institute for Cancer Research Cancer Care Ontario, Toronto, Ontario, Canada
    Hepatology 58:1375-84. 2013
    ....
  9. ncbi request reprint Do older men benefit from curative therapy of localized prostate cancer?
    Shabbir M H Alibhai
    University Health Network, Room ENG 233, 200 Elizabeth St, Toronto, Ontario, Canada M5G 2C4
    J Clin Oncol 21:3318-27. 2003
    ....
  10. doi request reprint Is there an optimal comorbidity index for prostate cancer?
    Shabbir M H Alibhai
    Division of General Internal Medicine and Clinical Epidemiology, University Health Network, Toronto, Ontario, Canada
    Cancer 112:1043-50. 2008
    ..Comorbidity is an important consideration in oncology practice, particularly among older patients. Although a variety of comorbidity indices have been employed in research studies, it is unclear whether any one index is preferred...
  11. ncbi request reprint An unadjusted NNT was a moderately good predictor of health benefit
    Christopher A K Y Chong
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Clin Epidemiol 59:224-33. 2006
    ..Whether the number needed to treat (NNT) is sufficiently precise to use in clinical practice remains unclear. We compared unadjusted NNTs to quality-adjusted life years (QALYs) gained, a more comprehensive measures of health benefit...
  12. ncbi request reprint Continued undertreatment of older men with localized prostate cancer
    Kevin L Schwartz
    University of Toronto, School of Medicine, Toronto, Ontario, Canada
    Urology 62:860-5. 2003
    ..To explore the association among patient factors (age, comorbidity), disease-specific factors (stage, Gleason score), and suboptimal initial treatment in a cohort of men with localized prostate cancer...
  13. ncbi request reprint Is there age bias in the treatment of localized prostate carcinoma?
    Shabbir M H Alibhai
    Division of General Internal Medicine and Clinical Epidemiology, University Health Network, Toronto, Ontario, Canada
    Cancer 100:72-81. 2004
    ..Previous studies have evaluated the influence of age and comorbidity, but to the authors' knowledge not RLE, on actual treatment decisions...
  14. pmc Management of solitary 1 cm to 2 cm liver nodules in patients with compensated cirrhosis: a decision analysis
    Karen E Bremner
    Toronto General Research Institute, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada
    Can J Gastroenterol 21:491-500. 2007
    ..Alternative strategies are immediate treatment or observation until disease progression occurs...
  15. ncbi request reprint The association between patient age and prostate cancer stage and grade at diagnosis
    Shabbir M H Alibhai
    Division of General Internal Medicine and Clinical Epidemiology, University Health Network, 200 Elizabeth Street, Toronto, Ontario M50 2C4, Canada
    BJU Int 94:303-6. 2004
    ..To investigate the association of age with prostate cancer stage and grade, as the latter factors at the time of diagnosis influence management and prognosis, with some studies suggesting that they may change as a function of patient age...
  16. doi request reprint Canada's contribution to global research in cardiovascular diseases
    Hai V Nguyen
    Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
    Can J Cardiol 29:742-6. 2013
    ..As the burden of chronic diseases including CVD rises with Canada's aging population, the increase in Canadian research into CVD is encouraging...
  17. doi request reprint Development and validation of a utility weighting function for the patient-oriented prostate utility scale (PORPUS)
    George Tomlinson
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Med Decis Making 32:11-30. 2012
    ..In this study, we developed a scoring system to allow indirect calculation of utilities from the PORPUS...
  18. ncbi request reprint Rethinking 30-day mortality risk after radical prostatectomy
    Shabbir M H Alibhai
    Division of General Internal Medicine and Clinical Epidemiology, University Health Network, Toronto, Ontario, Canada
    Urology 68:1057-60. 2006
    ..Although radical prostatectomy (RP) is associated with greater 30-day mortality in older men, the magnitude of the excess risk in older age groups compared with younger ones has not been well characterized...
  19. doi request reprint Natural history of hepatitis C virus infection in HIV-infected individuals and the impact of HIV in the era of highly active antiretroviral therapy: a meta-analysis
    Hla Hla Thein
    University Health Network, Division of Clinical Decision Making and Healthcare Research, Toronto, Canada
    AIDS 22:1979-91. 2008
    ....
  20. doi request reprint Sustained responders have better quality of life and productivity compared with treatment failures long after antiviral therapy for hepatitis C
    Ava A John-Baptiste
    Department of Health Policy, Management and Evaluation, University of Toronto, Toronto General Hospital, EN13 239, 200 Elizabeth Street, Toronto, ON M5G 2C4, Canada
    Am J Gastroenterol 104:2439-48. 2009
    ..We sought to compare the health status of patients with a sustained response to antiviral therapy for hepatitis C virus (HCV) infection with that of treatment failures, using health-related quality of life and preference (utility) measures...
  21. pmc Health status utilities and the impact of pressure ulcers in long-term care residents in Ontario
    Hla Hla Thein
    Toronto General Research Institute, University Health Network, Toronto, ON, Canada
    Qual Life Res 19:81-9. 2010
    ..To estimate health status utilities in long-term care (LTC) residents in Ontario, both with and without pressure ulcers (PUs), and to determine the impact of PU on health-related quality of life (HRQOL)...
  22. ncbi request reprint Azathioprine or ileocolic resection for steroid-dependent terminal ileal Crohn's disease? A Markov analysis
    Erin D Kennedy
    Department of Surgery and Medicine, University of Toronto, the Samuel Lunenfield Research Institute, Mount Sinai Hospital, Toronto, Canada
    Dis Colon Rectum 47:2120-30. 2004
    ....
  23. ncbi request reprint Health care costs for state transition models in prostate cancer
    Murray D Krahn
    Department of Medicine, Toronto, ON, Canada MDK, SMHA, GT, GN
    Med Decis Making 34:366-78. 2014
    ..To obtain estimates of direct health care costs for prostate cancer (PC) from diagnosis to death to inform state transition models...
  24. doi request reprint Patient time and out-of-pocket costs for long-term prostate cancer survivors in Ontario, Canada
    Claire de Oliveira
    Department of Social and Epidemiological Research, Centre for Addiction and Mental Health, 33 Russell Street, Room T414, Toronto, Ontario, M5S 2S1, Canada
    J Cancer Surviv 8:9-20. 2014
    ..We estimated these costs, their predictors, and their relationship to financial income, among a cohort of long-term prostate cancer (PC) survivors...
  25. ncbi request reprint Marker states and a health state prompt provide modest improvements in the reliability and validity of the standard gamble and rating scale in prostate cancer patients
    Karen E Bremner
    Toronto General Hospital, University Health Network, Toronto, ON, Canada
    Qual Life Res 16:1665-75. 2007
    ..To evaluate the combined effect of marker states and a prompt on the reliability and validity of direct utility assessment...
  26. ncbi request reprint The ten-year rule revisited: accuracy of clinicians' estimates of life expectancy in patients with localized prostate cancer
    Murray D Krahn
    Department of Medicine, University of Toronto School of Medicine, Toronto, Ontario, Canada
    Urology 60:258-63. 2002
    ....
  27. doi request reprint Predicting EQ-5D utility scores from the Seattle Angina Questionnaire in coronary artery disease: a mapping algorithm using a Bayesian framework
    Harindra C Wijeysundera
    Division of Cardiology, Schulich Heart Centre and Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada
    Med Decis Making 31:481-93. 2011
    ..In its current form, however, it cannot be used in economic evaluations. The investigators sought to create a mapping algorithm that would allow translation of SAQ scores into EQ-5D utility scores...
  28. pmc Influence of socioeconomic status on survival of hepatocellular carcinoma in the Ontario population; a population-based study, 1990-2009
    Nathaniel Jembere
    Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 7:e40917. 2012
    ..We aimed to assess if an association between SES and HCC survival existed in the Canadian context...
  29. doi request reprint Economics of preventing premature mortality and impaired cognitive development in children through home-fortification: a health policy perspective
    Waseem Sharieff
    Department of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada
    Int J Technol Assess Health Care 24:303-11. 2008
    ..Zinc supplementation may prevent morbidity and mortality related to diarrheal illnesses, and iron supplementation may improve cognitive development, in children...
  30. ncbi request reprint Delay in surgical therapy for clinically localized prostate cancer and biochemical recurrence after radical prostatectomy
    Robert K Nam
    Division of Urology, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Can J Urol 10:1891-8. 2003
    ..We examined whether delay from diagnosis for patients undergoing surgery for clinically localized prostate cancer affects cancer cure rates...
  31. ncbi request reprint International drug price comparisons: quality assessment
    Marcio Machado
    Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
    Rev Panam Salud Publica 29:46-51. 2011
    ..To quantitatively summarize results (i.e., prices and affordability) reported from international drug price comparison studies and assess their methodological quality...
  32. ncbi request reprint Content validity for dementia of three generic preference based health related quality of life instruments
    Michel Silberfeld
    Department of Psychiatry, Baycrest Centre for Geriatric Care, University of Toronto, Ontario, Canada
    Qual Life Res 11:71-9. 2002
    ..Compared to the respondent generated attributes all three utility-based quality of life instruments have important shortcomings in content validity...
  33. ncbi request reprint The cost effectiveness of rofecoxib and celecoxib in patients with osteoarthritis or rheumatoid arthritis
    Andreas Maetzel
    University Health Network, Toronto, Ontario, Canada
    Arthritis Rheum 49:283-92. 2003
    ..To evaluate the cost effectiveness of the cyclooxygenase 2 (COX-2) selective nonsteroidal antiinflammatory drug (NSAID) rofecoxib compared with naproxen and the COX-2 NSAID celecoxib compared with ibuprofen and diclofenac...
  34. pmc Economic appraisal of Ontario's Universal Influenza Immunization Program: a cost-utility analysis
    Beate Sander
    Department of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada
    PLoS Med 7:e1000256. 2010
    ..This is the first large-scale program of its kind worldwide. The objective of this study was to conduct an economic appraisal of Ontario's UIIP compared to a targeted influenza immunization program (TIIP)...
  35. ncbi request reprint The cost effectiveness of ACE inhibitors as first-line antihypertensive therapy
    Alain J Nordmann
    The Programme in Clinical Epidemiology and Health Care Research, University of Toronto, Toronto, Ontario, Canada
    Pharmacoeconomics 21:573-85. 2003
    ..Current hypertension guidelines differ in their recommendations for first-line antihypertensive therapy...
  36. pmc Neck pain patients' preference scores for their current health
    Gabrielle van der Velde
    Toronto Health Economics and Technology Assessment THETA Collaborative, University of Toronto, Leslie Dan Pharmacy Building, 6th Floor, Room 658, 144 College Street, and Centre for Research on Inner City Health, Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, ON, M5S 3M2, Canada
    Qual Life Res 19:687-700. 2010
    ..To elicit neck pain (NP) patients' preference scores for their current health, and investigate the association between their scores and NP disability...
  37. ncbi request reprint Decision analysis in aerospace medicine: costs and benefits of a hyperbaric facility in space
    Ava John-Baptiste
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Aviat Space Environ Med 77:434-42; discussion 442-3. 2006
    ..We illustrate the use of decision analysis to compare a hyperbaric oxygen (HBO) chamber to currently available therapy for DCS treatment on the ISS...
  38. ncbi request reprint Tenofovir and entecavir are the most effective antiviral agents for chronic hepatitis B: a systematic review and Bayesian meta-analyses
    Gloria Woo
    Toronto Health Economics and Technology Assessment Collaborative, University of Toronto, Toronto, Ontario, Canada
    Gastroenterology 139:1218-29. 2010
    ..We evaluated the relative efficacies of the first 12 months of CHB treatments...
  39. pmc Economic analysis of Heart and Stroke Foundation of Ontario's Hypertension Management Initiative
    Claire de Oliveira
    University Health Network, Toronto, ON, Canada Toronto Health Economics and Technology Assessment Collaborative, Toronto, ON, Canada
    Clinicoecon Outcomes Res 4:323-36. 2012
    ....
  40. pmc Techniques for estimating health care costs with censored data: an overview for the health services researcher
    Harindra C Wijeysundera
    Division of Cardiology, Schulich Heart Centre and Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    Clinicoecon Outcomes Res 4:145-55. 2012
    ..The target audience is health service researchers without an advanced statistical background...
  41. doi request reprint Cost-utility analysis of primary prophylaxis versus secondary prophylaxis with granulocyte colony-stimulating factor in elderly patients with diffuse aggressive lymphoma receiving curative-intent chemotherapy
    Kelvin K W Chan
    Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    J Clin Oncol 30:1064-71. 2012
    ..We examined the cost-effectiveness of PP when compared with SP...
  42. pmc Modelling mitigation strategies for pandemic (H1N1) 2009
    Marija Zivkovic Gojovic
    Toronto Health Economics and Technology Assessment Collaborative, University of Toronto, Research Institute of the Hospital for Sick Children, Toronto, ON
    CMAJ 181:673-80. 2009
    ..Simulation models can be used to project the effectiveness of mitigation strategies, but the choice of the best scenario may change depending on model assumptions and uncertainties...
  43. pmc Predictors of antiviral therapy in a post-transfusion cohort of hepatitis C patients
    Maciej Witkos
    Department of Health Policy, Management and Evaluation, University of Toronto, Toronto General Hospital, Ontario, Canada
    Can J Gastroenterol 20:107-11. 2006
    ..The efficacy of therapy has recently improved with the addition of ribavirin and pegylated interferon. The aim of the present study was to identify the clinical, socioeconomic and health-system predictors of antiviral treatment for HCV...
  44. ncbi request reprint Kidney transplantation in the elderly: a decision analysis
    Sarbjit V Jassal
    Division of Nephrology, University Health Network, Toronto, Ontario, Canada
    J Am Soc Nephrol 14:187-96. 2003
    ..Prolonged waiting times dramatically decrease the clinical benefits and economic attractiveness of transplantation, suggesting that living donor transplantation may be of particular benefit in this population...
  45. doi request reprint Estimation of stage-specific fibrosis progression rates in chronic hepatitis C virus infection: a meta-analysis and meta-regression
    Hla Hla Thein
    University Health Network, Division of Clinical Decision Making and Health Care Research, Toronto, Ontario, Canada
    Hepatology 48:418-31. 2008
    ..Duration of infection was the most consistent factor significantly associated with progression of fibrosis...
  46. ncbi request reprint Utility-based Quality of Life measures in Alzheimer's disease
    Gary Naglie
    Division of General Internal Medicine and Clinical Epidemiology, University Health Network, Toronto, Ontario, Canada
    Qual Life Res 15:631-43. 2006
    ....
  47. doi request reprint Identifying the best treatment among common nonsurgical neck pain treatments: a decision analysis
    Gabrielle van der Velde
    Institute for Work and Health, Toronto, ON, Canada
    Spine (Phila Pa 1976) 33:S184-91. 2008
    ..Decision analysis...
  48. pmc How much are we spending? The estimation of research expenditures on cardiovascular disease in Canada
    Claire de Oliveira
    University Health Network, Toronto, ON, Canada
    BMC Health Serv Res 12:281. 2012
    ..Our objective was to estimate the magnitude of expenditures on CVD research for the public and charitable (not-for profit) sectors in Canada between 1975 and 2005...
  49. ncbi request reprint Potential cost-effectiveness of a preventive hepatitis C vaccine in high risk and average risk populations in Canada
    Murray D Krahn
    Department of Medicine, University Health Network, Department of Health Policy, Management and Evaluation, University of Toronto, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 1C4
    Vaccine 23:1549-58. 2005
    ..These results provide encouragement to vaccine developers that a vaccine that is moderately effective and reasonably priced should not face economic barriers to implementation and will be attractive to third party payers...
  50. ncbi request reprint Patient and community preferences for outcomes in prostate cancer: implications for clinical policy
    Murray Krahn
    Department of Medicine And Programme in Clinical Epidemiology and Health Care Research, University of Toronto, Ontario, Candada
    Med Care 41:153-64. 2003
    ..Utilities can be elicited directly from patients using standard techniques, or indirectly, using questionnaires that incorporate preference weights from community members...
  51. ncbi request reprint Health-state utilities and quality of life in hepatitis C patients
    Christopher A K Y Chong
    Faculty of Medicine, University of Toronto, Ontario, Canada
    Am J Gastroenterol 98:630-8. 2003
    ..Currently, utilities for hepatitis C virus (HCV)-infected patients have been estimated using expert judgments. The purpose of this study was to elicit HCV utilities directly from patients...
  52. ncbi request reprint Life expectancy gains and cost-effectiveness of implantable cardioverter/defibrillators for the primary prevention of sudden cardiac death in patients with hypertrophic cardiomyopathy
    John J You
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Am Heart J 154:899-907. 2007
    ..Sudden cardiac death (SCD) is a devastating complication of hypertrophic cardiomyopathy (HCM). The optimal strategy for the primary prevention of SCD in HCM remains controversial...
  53. ncbi request reprint Cost-effectiveness analyses of hepatitis A vaccine: a systematic review to explore the effect of methodological quality on the economic attractiveness of vaccination strategies
    Andrea M Anonychuk
    Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
    Pharmacoeconomics 26:17-32. 2008
    ..Methodological quality varied across studies. Major methodological flaws included inappropriate model type, comparator, incidence estimate and inclusion/exclusion of costs...
  54. ncbi request reprint The half-cycle correction revisited: redemption of a kludge
    David M J Naimark
    Department of Medicine, University of Toronto, Toronto, ON, Canada DMJN, MDK
    Med Decis Making 33:961-70. 2013
    ....
  55. doi request reprint Systematic review, critical appraisal, and analysis of the quality of economic evaluations in stroke imaging
    Kirsteen R Burton
    From the Institute of Health Policy, Management and Evaluation K R B, n p, M K K, M D K, A L, Departments of Medical Imaging K R B, R I A, A R M, Surgery, Division of Urology N P, Institute of Medical Science R I A, A R M, Medicine M K K, M D K, A L, and Toronto Health Economics and Technology Assessment Collaborative M D K, University of Toronto, Toronto, ON, Canada Institute for Clinical and Evaluative Sciences, Toronto, ON, Canada M K K and Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, ON, Canada A L
    Stroke 45:807-14. 2014
    ..This study reviews the quality of economic evaluations of imaging after acute stroke and identifies areas for improvement...
  56. doi request reprint Is a mass immunization program for pandemic (H1N1) 2009 good value for money? Evidence from the Canadian Experience
    Beate Sander
    Department of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada
    Vaccine 28:6210-20. 2010
    ....
  57. ncbi request reprint Indications for interferon/ribavirin therapy in hepatitis C patients: findings from a survey of Canadian hepatologists
    Peter Wang
    Toronto General Hospital, Toronto, Canada
    Can J Gastroenterol 17:183-6. 2003
    ..To survey practising hepatologists about their attitudes and practices regarding interferon and ribavirin combination therapy for hepatitis C (HCV) patients in Canada...
  58. ncbi request reprint Estimating the prognosis of hepatitis C patients infected by transfusion in Canada between 1986 and 1990
    Murray Krahn
    Toronto General Hospital, ES9 408, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada
    Med Decis Making 24:20-9. 2004
    ..To develop a natural history model for chronic hepatitis C virus (HCV) infection to determine allocation of compensatory funds to Canadians who acquired HCV through the blood supply from 1986 through 1990...
  59. doi request reprint Acute appendicitis in young children: cost-effectiveness of US versus CT in diagnosis--a Markov decision analytic model
    Michael J Wan
    Department of Diagnostic Imaging, Hospital for Sick Children, Toronto, ON, Canada
    Radiology 250:378-86. 2009
    ..To compare the cost-effectiveness of different imaging strategies in the diagnosis of pediatric appendicitis by using a decision analytic model...
  60. doi request reprint The half-cycle correction explained: two alternative pedagogical approaches
    David M J Naimark
    Division of Nephrology, Sunny brook and Women s College Health Sciences Centre, Toronto, Canada
    Med Decis Making 28:706-12. 2008
    ..Elements of adult learning theory are discussed, which may help the instructor to choose which approach to employ. Implementation of the half-cycle correction in commonly used decision-analytic software is also discussed...
  61. ncbi request reprint Reliability and validity of the PORPUS, a combined psychometric and utility-based quality-of-life instrument for prostate cancer
    Paul Ritvo
    York University, and Cancer Care Ontario, Division of Preventive Oncology, 620 University Ave, 1236, Toronto, Ontario M5G, Canada
    J Clin Epidemiol 58:466-74. 2005
    ..In this study we developed and tested these two forms of quality-of-life instruments, both based on a single, validated, health classification system...
  62. pmc Prescribing patterns for Alzheimer disease: survey of Canadian family physicians
    Melinda Hillmer
    Faculty of Medicine, University of Toronto, Ontario
    Can Fam Physician 52:208-9. 2006
    ..To describe Canadian family physicians' prescribing practices with regard to Alzheimer disease (AD)...
  63. ncbi request reprint Responsiveness of disease-specific and generic utility instruments in prostate cancer patients
    Murray Krahn
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Qual Life Res 16:509-22. 2007
    ..Preferences (utilities) for health outcomes have an important role in decisions about prostate cancer screening and treatment. The responsiveness of utility instruments has not been evaluated...
  64. pmc The effect of English language proficiency on length of stay and in-hospital mortality
    Ava John-Baptiste
    Division of General Internal Medicine, Department of Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Gen Intern Med 19:221-8. 2004
    ..In ambulatory care settings, patients with limited English proficiency receive lower quality of care. Limited information is available describing outcomes for inpatients...
  65. pmc Feasibility of internet-based health-related quality of life data collection in a large patient cohort
    Sacha Bhinder
    Faculty of Medicine, University of Toronto, Toronto, Canada
    J Med Internet Res 12:e35. 2010
    ..Internet-based HRQOL questionnaires are a potential solution, allowing home data collection with immediate storage in a central database...
  66. ncbi request reprint Quality of life in early Parkinson's disease: impact of dyskinesias and motor fluctuations
    Connie Marras
    Division of Neurology, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Mov Disord 19:22-8. 2004
    ..We conclude that motor complications that occur within the first 4 years of treatment of PD do not have a significant negative effect on quality of life as measured by a visual analogue scale for most patients...
  67. ncbi request reprint Economic issues in the use of office spirometry for lung health assessment
    Murray Krahn
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Can Respir J 10:320-6. 2003
    ..Such analyses should play a role in future clinical policy making. Even modest quit rates attributable to screening spirometry may result in highly favourable cost effectiveness ratios...
  68. pmc A review of interventions triggered by hepatitis A infected food-handlers in Canada
    Andrea C Tricco
    Epidemiology and Biostatistics, GlaxoSmithKline Canada, Mississauga, Ontario, Canada
    BMC Health Serv Res 6:157. 2006
    ..We undertook a systematic review of such incidents to evaluate the extent of viral transmission through food contamination and the scope of post-exposure prophylaxis (PEP) interventions...
  69. doi request reprint Association of temporal trends in risk factors and treatment uptake with coronary heart disease mortality, 1994-2005
    Harindra C Wijeysundera
    Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    JAMA 303:1841-7. 2010
    ..Coronary heart disease (CHD) mortality has declined substantially in Canada since 1994...
  70. ncbi request reprint Economic analysis of a phase III clinical trial evaluating the addition of total androgen suppression to radiation versus radiation alone for locally advanced prostate cancer (Radiation Therapy Oncology Group protocol 86-10)
    Andre Konski
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Radiat Oncol Biol Phys 63:788-94. 2005
    ..To evaluate the cost-effectiveness of adding hormone therapy to radiation for patients with locally advanced prostate cancer, using a Monte Carlo simulation of a Markov Model...
  71. ncbi request reprint Estimation of utilities for chronic hepatitis C from SF-36 scores
    Hla Hla Thein
    National Centre in HIV Epidemiology and Clinical Research, The University of New South Wales, Sydney, NSW, Australia
    Am J Gastroenterol 100:643-51. 2005
    ..The aim of this study was to estimate utilities for chronic hepatitis C health states from published studies reporting Short Form-36 (SF-36) quality-of-life scores...
  72. pmc The effect of hepatitis C virus infection on health-related quality of life in prisoners
    Hla Hla Thein
    National Centre in HIV Epidemiology and Clincal Research, The University of New South Wales, Sydney, NSW, Australia
    J Urban Health 83:275-88. 2006
    ..Non-HCV factors may override HCV-specific HRQOL impairment in this population. Targeted management strategies are required to improve HRQOL of prisoners...