A D Krahn

Summary

Affiliation: University of Western Ontario
Country: Canada

Publications

  1. ncbi Recurrent unexplained syncope: diagnostic and therapeutic approach
    A D Krahn
    Department of Medicine, University of Western Ontario, London
    Can J Cardiol 12:989-94. 1996
  2. ncbi Predicting the outcome of patients with unexplained syncope undergoing prolonged monitoring
    Andrew D Krahn
    Division of Cardiology, University of Western Ontario, London, Ontario, Canada
    Pacing Clin Electrophysiol 25:37-41. 2002
  3. ncbi Beta blockers normalize QT hysteresis in long QT syndrome
    Andrew D Krahn
    Division of Cardiology, University of Western Ontario, London, Ontario, Canada
    Am Heart J 143:528-34. 2002
  4. ncbi A randomized, double-blind, placebo-controlled evaluation of the efficacy and safety of intravenously administered dofetilide in patients with Wolff-Parkinson-White syndrome
    A D Krahn
    Division of Cardiology, University of Western Ontario, London, Canada
    Pacing Clin Electrophysiol 24:1258-60. 2001
  5. ncbi Predictive value of presyncope in patients monitored for assessment of syncope
    A D Krahn
    Division of Cardiology, University of Western Ontario, London, Canada
    Am Heart J 141:817-21. 2001
  6. ncbi A novel mutation in KVLQT1, L122P, found in a family with autosomal dominant long QT syndrome
    A D Krahn
    Division of Cardiology and the Blackburn Cardiovascular Genetics Laboratory, Robarts Research Institute, University of Western Ontario, London, Ontario, Canada
    Am Heart J 140:146-9. 2000
  7. ncbi Use of an extended monitoring strategy in patients with problematic syncope. Reveal Investigators
    A D Krahn
    Division of Cardiology, University of Western Ontario, London, Ontario, Canada
    Circulation 99:406-10. 1999
  8. ncbi Progressive anterior ablation in the coronary sinus region: evidence to support the presence of a 'slow pathway' input in normal patients?
    A D Krahn
    Division of Cardiology, University of Western Ontario, London, Canada
    Circulation 96:3477-83. 1997
  9. ncbi Time-dependent change in fast pathway refractoriness after slow pathway ablation in atrioventricular node reentrant tachycardia. Mansfield Polaris Investigators
    A D Krahn
    Division of Cardiology, University Hospital, University of Western Ontario, London
    Can J Cardiol 13:583-8. 1997
  10. ncbi Hysteresis of the RT interval with exercise: a new marker for the long-QT syndrome?
    A D Krahn
    Department of Medicine, University of Western Ontario, Canada
    Circulation 96:1551-6. 1997

Collaborators

Detail Information

Publications83

  1. ncbi Recurrent unexplained syncope: diagnostic and therapeutic approach
    A D Krahn
    Department of Medicine, University of Western Ontario, London
    Can J Cardiol 12:989-94. 1996
    ..In the future, such a device may assume a prominent role in the investigation of syncope...
  2. ncbi Predicting the outcome of patients with unexplained syncope undergoing prolonged monitoring
    Andrew D Krahn
    Division of Cardiology, University of Western Ontario, London, Ontario, Canada
    Pacing Clin Electrophysiol 25:37-41. 2002
    ..01). The etiology of recurrent syncope is diverse and cannot be predicted by baseline clinical variables. Empiric pacing appears to have little role in the management of this patient population...
  3. ncbi Beta blockers normalize QT hysteresis in long QT syndrome
    Andrew D Krahn
    Division of Cardiology, University of Western Ontario, London, Ontario, Canada
    Am Heart J 143:528-34. 2002
    ..This study was performed to evaluate the impact of beta blockers on QT adaptation to heart rate during the exercise and recovery phases of exercise testing in long QT syndrome...
  4. ncbi A randomized, double-blind, placebo-controlled evaluation of the efficacy and safety of intravenously administered dofetilide in patients with Wolff-Parkinson-White syndrome
    A D Krahn
    Division of Cardiology, University of Western Ontario, London, Canada
    Pacing Clin Electrophysiol 24:1258-60. 2001
    ..046). Atrial fibrillation converted to sinus rhythm in 82% of patients who received dofetilide. Intravenous dofetilide was safe and effective at converting induced atrial fibrillation in patients with WPW syndrome...
  5. ncbi Predictive value of presyncope in patients monitored for assessment of syncope
    A D Krahn
    Division of Cardiology, University of Western Ontario, London, Canada
    Am Heart J 141:817-21. 2001
    ..The purpose of this study was to assess the diagnostic value of recording the cardiac rhythm during presyncope in patients undergoing monitoring for undiagnosed syncope...
  6. ncbi A novel mutation in KVLQT1, L122P, found in a family with autosomal dominant long QT syndrome
    A D Krahn
    Division of Cardiology and the Blackburn Cardiovascular Genetics Laboratory, Robarts Research Institute, University of Western Ontario, London, Ontario, Canada
    Am Heart J 140:146-9. 2000
    ..Linkage and mutation analysis in long QT syndrome kindreds has demonstrated locus heterogeneity, with causative mutations reported in at least 5 different genes, including KVLQT1...
  7. ncbi Use of an extended monitoring strategy in patients with problematic syncope. Reveal Investigators
    A D Krahn
    Division of Cardiology, University of Western Ontario, London, Ontario, Canada
    Circulation 99:406-10. 1999
    ..A symptom-rhythm correlation is often difficult to obtain during spontaneous syncope because of its sporadic, infrequent, and unpredictable nature...
  8. ncbi Progressive anterior ablation in the coronary sinus region: evidence to support the presence of a 'slow pathway' input in normal patients?
    A D Krahn
    Division of Cardiology, University of Western Ontario, London, Canada
    Circulation 96:3477-83. 1997
    ..AV node modification is an emerging approach to rate control in patients with medically refractory atrial fibrillation. The mechanism of benefit of this procedure is not completely understood...
  9. ncbi Time-dependent change in fast pathway refractoriness after slow pathway ablation in atrioventricular node reentrant tachycardia. Mansfield Polaris Investigators
    A D Krahn
    Division of Cardiology, University Hospital, University of Western Ontario, London
    Can J Cardiol 13:583-8. 1997
    ..To determine the time course of change in fast pathway refractoriness after slow pathway ablation...
  10. ncbi Hysteresis of the RT interval with exercise: a new marker for the long-QT syndrome?
    A D Krahn
    Department of Medicine, University of Western Ontario, Canada
    Circulation 96:1551-6. 1997
    ..The diagnosis of the long-QT syndrome (LQTS) may be difficult to establish in patients with normal or borderline prolongation of the QT interval. Noninvasive markers are needed to identify patients with LQTS...
  11. ncbi Randomized assessment of syncope trial: conventional diagnostic testing versus a prolonged monitoring strategy
    A D Krahn
    Division of Cardiology, University of Western Ontario, London, Ontario, Canada
    Circulation 104:46-51. 2001
    ..005). CONCLUSIONS: A prolonged monitoring strategy is more likely to provide a diagnosis than conventional testing in patients with unexplained syncope. Consideration should be given to earlier implementation of a monitoring strategy...
  12. ncbi Rate-control versus conversion strategy in postoperative atrial fibrillation: a prospective, randomized pilot study
    J K Lee
    Arrhythmia Monitoring Unit, University of Western Ontario, London Health Sciences Centre, Canada
    Am Heart J 140:871-7. 2000
    ..The optimal strategy to treat the condition has not been established. Several retrospective studies have suggested that a primary rate-control strategy may be equivalent to a strategy that restores sinus rhythm...
  13. ncbi Sevoflurane has no effect on sinoatrial node function or on normal atrioventricular and accessory pathway conduction in Wolff-Parkinson-White syndrome during alfentanil/midazolam anesthesia
    M D Sharpe
    Department of Anaesthesia, London Health Sciences Centre, University Campus, University of Western Ontario, Canada
    Anesthesiology 90:60-5. 1999
    ....
  14. ncbi Safety and feasibility of a novel rate-smoothed ventricular pacing algorithm for atrial fibrillation
    C S Simpson
    Arrhythmia Service, Division of Cardiology, London Health Sciences Centre, London, Ontario, Canada
    Am Heart J 142:294-300. 2001
    ..The RSA may help to reduce symptoms in patients with medically refractory AF; more study is required to define its efficacy in reducing symptoms and morbidity in this population...
  15. ncbi Supraventricular tachycardia
    V S Chauhan
    Division of Cardiology, Department of Medicine, University of Western Ontario, London, Ontario, Canada
    Med Clin North Am 85:193-223, ix. 2001
    ..The mechanism and clinical manifestation of SVTs, which is essential to their correct diagnosis, is reviewed. The therapeutic management of SVTs, including acute and chronic drug therapy and catheter ablation, is discussed also...
  16. ncbi Cryothermal ablation of the slow pathway for the elimination of atrioventricular nodal reentrant tachycardia
    A C Skanes
    Arrhythmia Services, University of Western Ontario, Montreal, Quebec, Canada
    Circulation 102:2856-60. 2000
    ..We report the first successful slow pathway ablation using a novel catheter-based cryothermal technology for the elimination of atrioventricular nodal reentrant tachycardia (AVNRT)...
  17. ncbi Recurrent seizure diagnosed by the insertable loop recorder
    C S Simpson
    Arrhythmia Service, London Health Sciences Centre London, Ontario, Canada
    J Interv Card Electrophysiol 4:475-9. 2000
    ..The Insertable Loop Recorder (ILR) has emerged as an important new tool in the diagnostic armamentarium for patients with syncope...
  18. ncbi Use of medications in Wolff-Parkinson-White syndrome
    D P Redfearn
    Division of Cardiology, University of Western Ontario, London, Ontario, Canada
    Expert Opin Pharmacother 6:955-63. 2005
    ..An overview of the agents commonly used is provided together with recommendations...
  19. ncbi Progression to chronic atrial fibrillation after pacing: the Canadian Trial of Physiologic Pacing. CTOPP Investigators
    A C Skanes
    Division of Cardiology, University of Western Ontario, London, Canada
    J Am Coll Cardiol 38:167-72. 2001
    ..This study examined the effect of physiologic pacing on the development of chronic atrial fibrillation (CAF) in the Canadian Trial Of Physiologic Pacing (CTOPP)...
  20. ncbi Correlation of waiting time with adverse events in patients admitted for nonelective permanent pacemaker implantation
    C S Simpson
    Division of Cardiology, University of Western Ontario, London
    Can J Cardiol 14:817-21. 1998
    ..To determine the effect of a dedicated permanent pacemaker implantation procedure room on waiting time and waiting time-related morbidity...
  21. ncbi Use of the implantable loop recorder in patients with unexplained syncope
    A D Krahn
    Division of Cardiology, University of Western Ontario, London, Ontario, Canada
    Minerva Cardioangiol 51:21-7. 2003
    ....
  22. ncbi Clinical relevance of arrhythmias during sleep: guidance for clinicians
    L J Gula
    Department of Medicine, University of Western Ontario, London, Ontario, Canada
    Heart 90:347-52. 2004
  23. ncbi Formation of a national network for rapid response to device and lead advisories: The Canadian Heart Rhythm Society Device Advisory Committee
    A D Krahn
    London Health Sciences Centre, London, Canada
    Can J Cardiol 25:403-5. 2009
    ..The network is an ideal tool to collect specific data on implanted device system performance and allows for prompt reporting of clinically relevant data to front-line clinicians and patients...
  24. ncbi Implications of mechanism of bradycardia on response to pacing in patients with unexplained syncope
    Sachin Sud
    Division of Cardiology, University of Western Ontario, London Health Sciences Centre, University Campus, C6 113 339 Windermere road, London, Ontario N6A 5A5, Canada
    Europace 9:312-8. 2007
    ....
  25. ncbi Differentiating arrhythmogenic right ventricular cardiomyopathy from right ventricular outflow tract ventricular tachycardia using multilead QRS duration and axis
    Craig D Ainsworth
    Division of Cardiology, University of Western Ontario, London, Canada
    Heart Rhythm 3:416-23. 2006
    ..CONCLUSION: QRS duration is longer in ARVC compared with RVOT VT. An algorithm combining lead I QRS duration for sensitivity and axis for specificity is useful for differentiating the two tachycardia substrates...
  26. ncbi Detection of asymptomatic arrhythmias in unexplained syncope
    Andrew D Krahn
    Division of Cardiology, University of Western Ontario, London, Ontario, Canada
    Am Heart J 148:326-32. 2004
    ..We hypothesized that long-term monitoring of patients with syncope would yield significant asymptomatic abnormalities that might preclude waiting for recurrence of actual syncope...
  27. ncbi Relationships between sinus rhythm, treatment, and survival in the Atrial Fibrillation Follow-Up Investigation of Rhythm Management (AFFIRM) Study
    Scott D Corley
    Axio Research Corporation, Seattle, Wash, USA
    Circulation 109:1509-13. 2004
    ..If an effective method for maintaining SR with fewer adverse effects were available, it might be beneficial...
  28. ncbi Pacing for vasovagal syncope after the second Vasovagal Pacemaker Study (VPS II): a matter of judgement
    Geoffrey M Trim
    Division of Cardiology, University of Western Ontario, London, Ontario, Canada
    Card Electrophysiol Rev 7:416-20. 2003
    ..More needs to be learned about optimal pacing modalities...
  29. ncbi Effect of change in posture and exercise on repolarization in patients with long QT syndrome with HERG channel mutations
    Bruce D Walker
    Division of Cardiology and the Blackburn Genetics Laboratory, Roberts Research Institute, University of Western Ontario, London
    Can J Cardiol 21:33-8. 2005
    ..CONCLUSIONS: Abnormal repolarization in LQT2 is accentuated by a change in posture and exercise. Beta-blockers normalize the QTc prolongation elicited by such manoeuvres...
  30. ncbi Sudden intense exercise increases QT heart rate slope and T wave complexity in long QT syndrome and normal subjects
    Vijay S Chauhan
    Division of Cardiology, University of Western Ontario, London, Canada
    Pacing Clin Electrophysiol 27:1415-23. 2004
    ....
  31. ncbi A novel pacing maneuver to localize focal atrial tachycardia
    Uwais Mohamed
    Division of Cardiology, Department of Medicine, University of Western Ontario, London, Ontario, Canada
    J Cardiovasc Electrophysiol 18:1-6. 2007
    ....
  32. ncbi Rate-control versus conversion strategy in postoperative atrial fibrillation: trial design and pilot study results
    John K Lee
    The Arrhythmia Service, University of Western Ontario, London Health Sciences Centre, London, Ontario, Canada
    Card Electrophysiol Rev 7:178-84. 2003
    ..Regardless of the strategy, majority of patients will be in sinus rhythm after two months. A larger randomized, controlled study is needed to assess the impact of restoration of sinus rhythm on length of stay...
  33. ncbi Sex differences in QTc interval and QT dispersion: dynamics during exercise and recovery in healthy subjects
    Vijay S Chauhan
    Division of Cardiology, University of Western Ontario, London, Ontario, Canada
    Am Heart J 144:858-64. 2002
    ..Greater QT prolongation during decelerating heart rates in recovery may play a role in increasing proarrhythmia risk in women...
  34. ncbi Current of injury predicts acute performance of catheter-delivered active fixation pacing leads
    Damian P Redfearn
    Division of Cardiology, University of Western Ontario, London, Ontario, Canada
    Pacing Clin Electrophysiol 30:1438-44. 2007
    ..Continuously monitoring lead parameters during fixation might better identify predictors of acute lead stability and performance...
  35. ncbi Investigating syncope: a review
    Paul A Gould
    Division of Cardiology, University of Western Ontario, London, Ontario, Canada
    Curr Opin Cardiol 21:34-41. 2006
    ..Electrophysiological studies have largely been supplanted by implantable cardioverter defibrillator use in structural heart disease, with a low yield in patients with preserved heart function...
  36. ncbi Is ambulatory monitoring for "community-acquired" syncope economically attractive? A cost-effectiveness analysis of a randomized trial of external loop recorders versus Holter monitoring
    Marie Antoinette Rockx
    Division of Cardiology, Department of Medicine, University of Western Ontario, London, Ontario, Canada
    Am Heart J 150:1065. 2005
    ..The cost-effectiveness of 2 monitoring strategies was assessed in a prospective randomized trial...
  37. ncbi Comparison of patients with syncope with left ventricular dysfunction and negative electrophysiologic testing to cardiac arrest survivors and patients with syncope and preserved left ventricular function and impact of an implantable defibrillator
    Paul Lelorier
    London Health Sciences Center, University of Western Ontario, London, Ontario, Canada
    Am J Cardiol 90:77-9. 2002
  38. ncbi Utility of a simplified lidocaine and potassium infusion in diagnosing long QT syndrome among patients with borderline QTc interval prolongation
    Vijay S Chauhan
    Division of Cardiology, University of Western Ontario, London, ON, Canada
    Ann Noninvasive Electrocardiol 9:12-8. 2004
    ..This study compared the response of the QTc interval and QT dispersion to a sequential lidocaine/K+ infusion in LQTS patients with borderline QTc interval prolongation and control patients as a means of diagnosing LQTS...
  39. ncbi Unexpected AV block during cavotricuspid isthmus ablation
    Emoke Posan
    Division of Cardiology, Department of Medicine, University of Western Ontario, London Health Sciences Center, 339 Windermere Road, London, Ontario, Canada N6A 5A5
    Pacing Clin Electrophysiol 28:980-1. 2005
  40. ncbi Using the net benefit regression framework to construct cost-effectiveness acceptability curves: an example using data from a trial of external loop recorders versus Holter monitoring for ambulatory monitoring of "community acquired" syncope
    Jeffrey S Hoch
    Centre for Research on Inner City Health, St Michael s Hospital, Toronto, Canada
    BMC Health Serv Res 6:68. 2006
    ..The net benefit regression framework (NBRF) allows cost-effectiveness analysis to be done in a simple regression framework. The objective of the paper is to illustrate how net benefit regression can be used to construct a CEAC...
  41. ncbi Age of first faint in patients with vasovagal syncope
    Robert S Sheldon
    Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada
    J Cardiovasc Electrophysiol 17:49-54. 2006
    ..Accordingly, we determined the age of the first syncopal spell in adult patients who sought care for syncope...
  42. ncbi Diagnosis of unexplained cardiac arrest: role of adrenaline and procainamide infusion
    Andrew D Krahn
    Division of Cardiology, University of Western Ontario, London, Canada
    Circulation 112:2228-34. 2005
    ..Although these may be evident on the ECG, long-term monitoring or provocative testing is often necessary to unmask latent primary electrical disease...
  43. ncbi Burst bicycle exercise facilitates diagnosis of latent long QT syndrome
    Bruce D Walker
    Division of Cardiology, University of Western Ontario, London, Ontario, Canada
    Am Heart J 150:1059-63. 2005
    ..0004). CONCLUSION: Marked QTc prolongation during burst bicycle ergometry provides potentially diagnostic information for patients with normal baseline QTc and suspected LQTS...
  44. ncbi A classic but uncommon principle
    Emoke Posan
    Department of Medicine, Division of Cardiology at London Health Science Centre, London, Ontario, Canada
    J Cardiovasc Electrophysiol 17:106-7. 2006
  45. ncbi Effect of defibrillation testing on management during implantable cardioverter-defibrillator implantation
    Peter Leong-Sit
    Division of Cardiology, University of Western Ontario, London, Ontario, Canada
    Am Heart J 152:1104-8. 2006
    ..Defibrillation threshold testing appears to be most useful for patients taking amiodarone...
  46. ncbi Images in cardiovascular medicine. A sensitive dissection: profound bradycardia complicating carotid dissection
    Daisy Dulay
    FRCPC, London Health Sciences Centre, Arrhythmia Service, 339 Windermere Rd, London, Ontario, Canada
    Circulation 118:e152-3. 2008
  47. ncbi Reduction of complex ventricular ectopy and improvement in exercise capacity with flecainide therapy in Andersen-Tawil syndrome
    David J Fox
    Department of Medicine, Division of Cardiology, University of Western Ontario, London, Ontario, Canada
    Europace 10:1006-8. 2008
    ....
  48. ncbi Utility of isoproterenol in unmasking latent escape rhythm in pacemaker dependent patients undergoing pacemaker replacement
    Stephen M Chihrin
    Division of Cardiology, University of Western Ontario, London, Ontario, Canada
    Am J Cardiol 101:631-3. 2008
    ..In conclusion, this suggests that a standardized protocol to elicit an underlying rhythm in patients previously assessed as pacemaker dependent effectively minimizes the need for temporary pacing during device replacement...
  49. ncbi Feasibility of magnetic resonance imaging in patients with an implantable loop recorder
    Jorge A Wong
    Division of Cardiology, University of Western Ontario, London, Ontario, Canada
    Pacing Clin Electrophysiol 31:333-7. 2008
    ..Our understanding of their functional and safety profile in interfering environments such as magnetic resonance imaging (MRI) becomes increasingly important as they become more prevalent...
  50. ncbi Take heart: gone but not forgotten?
    David J Fox
    Division of Cardiology, Department of Medicine, University of Western Ontario, London, Ontario, Canada
    J Cardiovasc Electrophysiol 19:438-9. 2008
  51. ncbi When should we recommend catheter ablation for patients with the Wolff-Parkinson-White syndrome?
    Alexander Tischenko
    Arrhythmia Service, London Health Sciences Centre, London, Ontario, Canada
    Curr Opin Cardiol 23:32-7. 2008
    ..Its application in asymptomatic individuals with WPW pattern remains controversial. This review will elaborate on the role of catheter ablation in symptomatic and asymptomatic patients with WPW pattern on ECG...
  52. ncbi Noninvasive assessment of atrial substrate change after wide area circumferential ablation: a comparison with segmental pulmonary vein isolation
    Damian P Redfearn
    Arrhythmia Service, London Health Sciences Centre, London, Ontario, Canada
    Ann Noninvasive Electrocardiol 12:329-37. 2007
    ..We examined this prospectively by comparing WACA and segmental pulmonary vein isolation (PVI) using noninvasive surrogate markers...
  53. ncbi A sheep in wolf's clothing?
    Oliver R Segal
    Department of Medicine, Division of Cardiology at London Health Science Centre, London, Canada
    J Cardiovasc Electrophysiol 18:1338-9. 2007
  54. ncbi Arrhythmia device lead extraction: factors that necessitate laser assistance
    Lorne J Gula
    Department of Medicine, University of Western Ontario, London, Canada
    Can J Cardiol 24:767-70. 2008
    ..It is not an option at all centres and introduces an element of risk to the procedure. Anticipation of the need for laser assistance may be of benefit to procedure planning...
  55. ncbi The expectation effect and cardiac pacing for refractory vasovagal syncope
    Sachin Sud
    Division of Cardiology, Department of Medicine, University of Western Ontario, London, Ontario, Canada
    Am J Med 120:54-62. 2007
    ..Clinical trials of pacing for vasovagal syncope have shown conflicting results. We performed a meta-analysis to determine whether permanent pacemaker therapy prevents refractory vasovagal syncope...
  56. ncbi Sudden cardiac death despite an implantable cardioverter-defibrillator in a young female with catecholaminergic ventricular tachycardia
    Uwais Mohamed
    Division of Cardiology, University of Western Ontario, London, Ontario, Canada
    Heart Rhythm 3:1486-9. 2006
  57. ncbi Physiologic pacing in patients with obstructive sleep apnea: a prospective, randomized crossover trial
    Andrew D Krahn
    Division of Cardiology, University of Western Ontario, London, Ontario, Canada
    J Am Coll Cardiol 47:379-83. 2006
    ..This study was designed to assess the impact of prevention of bradycardia with physiologic pacing on the severity of obstructive sleep apnea...
  58. ncbi Primary prophylaxis of sudden death in hypertrophic cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy, and dilated cardiomyopathy
    George J Klein
    Division of Cardiology, University of Western Ontario, London, Ontario, Canada
    J Cardiovasc Electrophysiol 16:S28-34. 2005
    ..A rational approach to these therapies, with emphasis on implanted cardiovertor defibrillators, is discussed...
  59. ncbi Optimal pacing for symptomatic AV block: a comparison of VDD and DDD pacing
    Max Huang
    Division of Cardiology, University of Western Ontario, London, Ontario, Canada
    Pacing Clin Electrophysiol 27:19-23. 2004
    ..The lower cost, high reliability, and abbreviated implantation time suggest that VDD pacing is a viable alternative to DDD pacing in patients with high degree AV block and normal sinus node function...
  60. ncbi Drug induced QT prolongation: lessons from congenital and acquired long QT syndromes
    Bruce D Walker
    Division of Cardiology, University of Western Ontario, London Ontario Canada
    Curr Drug Targets Cardiovasc Haematol Disord 3:327-35. 2003
    ..Discontinuation of the offending agent and supportive care are often all that is necessary when clinical arrhythmias arise...
  61. ncbi Optimal duration of monitoring in patients with unexplained syncope
    Manish D Assar
    Division of Cardiology, University of Western Ontario, London, Ontario, Canada
    Am J Cardiol 92:1231-3. 2003
    ..Syncope is most likely to occur in younger patients with less heart disease and more frequent syncope. There is a low risk of syncope after 1 year of monitoring without an event...
  62. ncbi Hybrid approach for minimally-invasive operative therapy of arrhythmias
    Allan C Skanes
    Arrhythmia Service, Division of Cardiology, University of Western Ontario, London Health Sciences Centre, University Campus, 339 Windermere Road, London, Ontario, Canada N6A 5A5
    J Interv Card Electrophysiol 9:289-94. 2003
    ..This step will be crucial in understanding why specific procedures ultimately fail to cure AF and other complex arrhythmias...
  63. ncbi Use of the implantable loop recorder in evaluation of patients with unexplained syncope
    Andrew D Krahn
    Division of Cardiology, University of Western Ontario, London, Ontario, Canada
    J Cardiovasc Electrophysiol 14:S70-3. 2003
    ....
  64. ncbi Cost implications of testing strategy in patients with syncope: randomized assessment of syncope trial
    Andrew D Krahn
    Division of Cardiology, Department of Medicine, University of Western Ontario, London, Ontario, Canada
    J Am Coll Cardiol 42:495-501. 2003
    ..We sought to assess the cost implications of two investigation strategies in patients with unexplained syncope...
  65. ncbi A prospective randomized comparison of loop recorders versus Holter monitors in patients with syncope or presyncope
    Soori Sivakumaran
    Division of Cardiology, University of Western Ontario, London, Ontario, Canada
    Am J Med 115:1-5. 2003
    ..CONCLUSION: Loop recorders have a much higher diagnostic yield for patients with syncope or presyncope as compared with Holter monitors. The utility of loop recorders is limited by some patients' inability to operate them correctly...
  66. ncbi Heart rate variability in obstructive sleep apnea: a prospective study and frequency domain analysis
    Lorne J Gula
    Divisions of Cardiology and Respirology University of Western Ontario London, Ont, Canada
    Ann Noninvasive Electrocardiol 8:144-9. 2003
    ..CPAP may restore autonomic defects, characteristic of severe OSA, to moderate levels...
  67. ncbi Transition from narrow to wide complex tachycardia: connection or coincidence?
    Manish D Assar
    Arrhythmia Service, London Health Sciences Center, London, Ontario, Canada
    Pacing Clin Electrophysiol 26:99-100. 2003
  68. ncbi Congenital and acquired long QT syndromes
    Bruce D Walker
    Division of Cardiology and the Blackburn Genetics Laboratory, Robarts Research Institute, University of Western Ontario, London
    Can J Cardiol 19:76-87. 2003
    ..This review summarizes the clinical, genetic and electrophysiological understanding of congenital and acquired LQTS...
  69. ncbi Syncope and polymorphic ventricular tachycardia
    Bruce D Walker
    Arrhythmia Service, London Health Sciences Center, Ontario, Canada
    Pacing Clin Electrophysiol 25:1259-61. 2002
  70. ncbi External loop recorders: determinants of diagnostic yield in patients with syncope
    Lorne J Gula
    Division of Cardiology, University of Western Ontario, London, Ontario, Canada
    Am Heart J 147:644-8. 2004
    ..Patients who are unfamiliar with technology, live alone, or have low motivation to reach a diagnosis have a lower diagnostic yield from ELRs for assessment of syncope...
  71. ncbi A wide QRS tachycardia: what is the diagnosis?
    Basilios Petrellis
    University of Western Ontario, London Health Sciences Centre, Arrhythmia Service, London, Ontario, Canada N6A 5A5
    J Cardiovasc Electrophysiol 15:501-3. 2004
  72. ncbi Tachycardia with VA dissociation: an unusual tachycardia mechanism
    Lorne J Gula
    Department of Medicine, Division of Cardiology at London Health Sciences Centre, London, Ontario N6A 5A5, Canada
    J Cardiovasc Electrophysiol 16:663-5. 2005
  73. ncbi Atrial response to ventricular antitachycardia pacing discriminates mechanism of 1:1 atrioventricular tachycardia
    Daryl P Ridley
    London Health Sciences Centre, London, Ontario N6A 5A5, Canada
    J Cardiovasc Electrophysiol 16:601-5. 2005
    ..CONCLUSION: Analysis of atrial response patterns during and after ventricular ATP can successfully discriminate tachycardia mechanism and may reduce inappropriate ICD shocks...
  74. ncbi Inaccurate electrocardiographic interpretation of long QT: the majority of physicians cannot recognize a long QT when they see one
    Sami Viskin
    Department of Cardiology, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Heart Rhythm 2:569-74. 2005
    ..It is important to define the percentage of physicians capable of distinguishing QT intervals that are long from those that are normal because LQTS can be lethal when left untreated...
  75. ncbi An unusual accessory pathway: anteroseptal to ventricular outflow region connection
    Basilios Petrellis
    University of Western Ontario, Arrhythmia Service, London, Ontario, Canada
    J Cardiovasc Electrophysiol 16:546-51. 2005
    ..This is the second such pathway observed at our institution over a 20-year period...
  76. ncbi Long-term outcome of cardiac resynchronization therapy in patients with severe congestive heart failure
    Darryl R Davis
    Division of Cardiology, University of Ottawa Heart Institute, University of Ottawa, Ottawa, Ontario, Canada
    Can J Cardiol 21:413-7. 2005
    ..The significant morbidity and mortality found after CRT highlight the severity of the underlying cardiac pathology and concurrent illnesses...
  77. ncbi Ciprofloxacin-induced acquired long QT syndrome
    Manu Prabhakar
    Division of Cardiology, University of Western Ontario, London, Canada
    Heart Rhythm 1:624-6. 2004
    ..This effect is of particular concern in patients with predisposing factors, such as concomitant medications or underlying heart disease reflecting decreased repolarization reserve...
  78. ncbi Laser lead extraction: is there a learning curve?
    Nina Ghosh
    Division of Cardiology and Cardiac Surgery, University of Western Ontario, London, Ontario, Canada
    Pacing Clin Electrophysiol 28:180-4. 2005
    ....
  79. ncbi Feasibility of his bundle pacing as an alternative pacing site: measurement of his refractoriness
    Lorne J Gula
    Division of Cardiology, University of Western Ontario, London, Ontario, Canada
    J Interv Card Electrophysiol 12:69-73. 2005
    ..Measurement of HERP and HFRP may prove useful in assessing the suitability of the His bundle for permanent pacing...
  80. ncbi The use of monitoring strategies in patients with unexplained syncope--role of the external and implantable loop recorder
    Andrew D Krahn
    Division of Cardiology, University of Western Ontario, London ON, Canada
    Clin Auton Res 14:55-61. 2004
    ....
  81. ncbi Diminishing proportional risk of sudden death with advancing age: implications for prevention of sudden death
    Andrew D Krahn
    Division of Cardiology, University of Western Ontario, London, Ontario, Canada
    Am Heart J 147:837-40. 2004
    ..We sought to determine the effect of advancing age on the mode of death in the Amiodarone Trialists Metanalysis...
  82. ncbi Insertable loop recorder use for detection of intermittent arrhythmias
    Andrew D Krahn
    Division of Cardiology, University of Western Ontario, London, Ontario, Canada
    Pacing Clin Electrophysiol 27:657-64. 2004
    ..The implantable loop recorder is most useful in patients with infrequent unexplained syncope when noninvasive testing is negative...
  83. ncbi Biventricular pacing improves quality of life and exercise tolerance in patients with heart failure and intraventricular conduction delay
    Andrew D Krahn
    London Health Sciences Centre, University Campus, London, Canada
    Can J Cardiol 18:380-7. 2002
    ..Identification of patients most likely to respond to biventricular pacing was not possible...