Olga Kovalchuk

Summary

Affiliation: University of Lethbridge
Country: Canada

Publications

  1. Wang B, Li D, Kovalchuk I, Apel I, Chinnaiyan A, Wóycicki R, et al. miR-34a directly targets tRNAiMet precursors and affects cellular proliferation, cell cycle, and apoptosis. Proc Natl Acad Sci U S A. 2018;115:7392-7397 pubmed publisher
  2. Wang B, Li D, Rodriguez Juarez R, Farfus A, Storozynsky Q, Malach M, et al. A suppressive role of guanine nucleotide-binding protein subunit beta-4 inhibited by DNA methylation in the growth of anti-estrogen resistant breast cancer cells. BMC Cancer. 2018;18:817 pubmed publisher
    ..Furthermore, knockdown of GNB4 decreased growth of both antiestrogen resistant and sensitive breast cancer cells. GNB4 is important for growth of breast cancer cells and a potential target for treatment. ..
  3. Wang B, Li D, Filkowski J, Rodriguez Juarez R, Storozynsky Q, Malach M, et al. A dual role of miR-22 modulated by RelA/p65 in resensitizing fulvestrant-resistant breast cancer cells to fulvestrant by targeting FOXP1 and HDAC4 and constitutive acetylation of p53 at Lys382. Oncogenesis. 2018;7:54 pubmed publisher
    ..HER2/NF-?B (p65)/miR-22/HDAC4/p21 and HER2/NF-?B (p65)/miR-22/Ac-p53/p21 signaling circuits may therefore confer this dual role on miR-22 through constitutive transactivation of p21. ..
  4. Luzhna L, Kutanzi K, Kovalchuk O. Gene expression and epigenetic profiles of mammary gland tissue: insight into the differential predisposition of four rat strains to mammary gland cancer. Mutat Res Genet Toxicol Environ Mutagen. 2015;779:39-56 pubmed publisher
    ..Moreover, we have identified several important differences in the basal epigenetic profile of four rat strains with varying degrees of susceptibility to spontaneous and induced mammary carcinogenesis. ..
  5. Kovalchuk O, Filkowski J, Meservy J, Ilnytskyy Y, Tryndyak V, Chekhun V, et al. Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin. Mol Cancer Ther. 2008;7:2152-9 pubmed publisher
  6. Krishnan P, Ghosh S, Wang B, Li D, Narasimhan A, Berendt R, et al. Next generation sequencing profiling identifies miR-574-3p and miR-660-5p as potential novel prognostic markers for breast cancer. BMC Genomics. 2015;16:735 pubmed publisher
    ..Independent validation of signatures (for OS) using an external dataset from TCGA further strengthened the study findings. ..