Olga Kovalchuk

Summary

Affiliation: University of Lethbridge
Country: Canada

Publications

  1. ncbi request reprint Estrogen-induced rat breast carcinogenesis is characterized by alterations in DNA methylation, histone modifications and aberrant microRNA expression
    Olga Kovalchuk
    Department of Biological Sciences, University of Lethbridge, Lethbridge, Canada
    Cell Cycle 6:2010-8. 2007
  2. doi request reprint Radiation-induced bystander effects in vivo are epigenetically regulated in a tissue-specific manner
    Yaroslav Ilnytskyy
    Department of Biological Sciences, University of Lethbridge, Alberta, Canada
    Environ Mol Mutagen 50:105-13. 2009
  3. ncbi request reprint Does bacterial infection cause genome instability and cancer in the host cell?
    Olga Kovalchuk
    Department of Biological Sciences, University of Lethbridge, Lethbridge T1K 3M4, Alberta, Canada Electronic address
    Mutat Res Fundam Mol Mech Mutagen 761:1-14. 2014
  4. pmc Induction and persistence of radiation-induced DNA damage is more pronounced in young animals than in old animals
    Darryl Hudson
    Department of Biological Sciences, University of Lethbridge, Lethbridge, AB, T1K 3M4 Canada
    Aging (Albany NY) 3:609-20. 2011
  5. pmc Epigenetic bystander-like effects of stroke in somatic organs
    Anna Kovalchuk
    Department of Biology, University of Lethbridge, Lethbridge, Alberta
    Aging (Albany NY) 4:224-34. 2012
  6. pmc Epigenetics in radiation biology: a new research frontier
    Matt Merrifield
    Department of Biological Sciences, University of Lethbridge Lethbridge, AB, Canada
    Front Genet 4:40. 2013
  7. ncbi request reprint Extremely complex pattern of microsatellite mutation in the germline of wheat exposed to the post-Chernobyl radioactive contamination
    Olga Kovalchuk
    Friedrich Miescher Institute, Novartis Research Foundation, PO Box 2543, CH 4002 Basel, Switzerland
    Mutat Res 525:93-101. 2003
  8. doi request reprint Epigenetic changes and nontargeted radiation effects--is there a link?
    Olga Kovalchuk
    Department of Biological Sciences, University of Lethbridge, Alberta, Canada
    Environ Mol Mutagen 49:16-25. 2008
  9. doi request reprint Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin
    Olga Kovalchuk
    Department of Biological Sciences, University of Lethbridge, Lethbridge, Alberta, Canada T1K 3M4
    Mol Cancer Ther 7:2152-9. 2008
  10. pmc microRNAome changes in bystander three-dimensional human tissue models suggest priming of apoptotic pathways
    Olga Kovalchuk
    Department of Biological Sciences, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, T1K 3M4 Canada
    Carcinogenesis 31:1882-8. 2010

Collaborators

Detail Information

Publications74

  1. ncbi request reprint Estrogen-induced rat breast carcinogenesis is characterized by alterations in DNA methylation, histone modifications and aberrant microRNA expression
    Olga Kovalchuk
    Department of Biological Sciences, University of Lethbridge, Lethbridge, Canada
    Cell Cycle 6:2010-8. 2007
    ..The results of this study show that deregulation of cellular epigenetic processes plays a crucial role in the mechanism of E(2)-induced mammary carcinogenesis in ACI rats, especially in the tumor initiation process...
  2. doi request reprint Radiation-induced bystander effects in vivo are epigenetically regulated in a tissue-specific manner
    Yaroslav Ilnytskyy
    Department of Biological Sciences, University of Lethbridge, Alberta, Canada
    Environ Mol Mutagen 50:105-13. 2009
    ..Future studies are clearly needed to address organismal and carcinogenic repercussions of those changes...
  3. ncbi request reprint Does bacterial infection cause genome instability and cancer in the host cell?
    Olga Kovalchuk
    Department of Biological Sciences, University of Lethbridge, Lethbridge T1K 3M4, Alberta, Canada Electronic address
    Mutat Res Fundam Mol Mech Mutagen 761:1-14. 2014
    ..We will discuss the mechanisms of host responses to the bacterial infection and present the possible pathways leading to genome instability and cancer through exposure to bacteria. ..
  4. pmc Induction and persistence of radiation-induced DNA damage is more pronounced in young animals than in old animals
    Darryl Hudson
    Department of Biological Sciences, University of Lethbridge, Lethbridge, AB, T1K 3M4 Canada
    Aging (Albany NY) 3:609-20. 2011
    ..The mechanisms of cell and tissue-specificity of in vivo IR responses need to be further dissected. This study provides a roadmap for the future analyses of DNA damage and repair induction in young individuals...
  5. pmc Epigenetic bystander-like effects of stroke in somatic organs
    Anna Kovalchuk
    Department of Biology, University of Lethbridge, Lethbridge, Alberta
    Aging (Albany NY) 4:224-34. 2012
    ....
  6. pmc Epigenetics in radiation biology: a new research frontier
    Matt Merrifield
    Department of Biological Sciences, University of Lethbridge Lethbridge, AB, Canada
    Front Genet 4:40. 2013
    ....
  7. ncbi request reprint Extremely complex pattern of microsatellite mutation in the germline of wheat exposed to the post-Chernobyl radioactive contamination
    Olga Kovalchuk
    Friedrich Miescher Institute, Novartis Research Foundation, PO Box 2543, CH 4002 Basel, Switzerland
    Mutat Res 525:93-101. 2003
    ..Our data also support the conclusion that the spectra of spontaneous and radiation-induced mutation in wheat may be similar...
  8. doi request reprint Epigenetic changes and nontargeted radiation effects--is there a link?
    Olga Kovalchuk
    Department of Biological Sciences, University of Lethbridge, Alberta, Canada
    Environ Mol Mutagen 49:16-25. 2008
    ..Transgeneration radiation effects were also proposed to be of an epigenetic nature. We will discuss the role of the epigenetic mechanisms in radiation responses, bystander effects, and transgeneration effects...
  9. doi request reprint Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin
    Olga Kovalchuk
    Department of Biological Sciences, University of Lethbridge, Lethbridge, Alberta, Canada T1K 3M4
    Mol Cancer Ther 7:2152-9. 2008
    ....
  10. pmc microRNAome changes in bystander three-dimensional human tissue models suggest priming of apoptotic pathways
    Olga Kovalchuk
    Department of Biological Sciences, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, T1K 3M4 Canada
    Carcinogenesis 31:1882-8. 2010
    ..In summary, this study creates a roadmap for understanding the role of microRNAome in RIBE and for developing novel RIBE biomarkers...
  11. ncbi request reprint Dissimilar genome response to acute and chronic low-dose radiation in male and female mice
    Olga Kovalchuk
    Department of Biological Sciences, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, Canada T1K 3M4
    Mutat Res 550:59-72. 2004
    ..If confirmed in other experimental systems, these findings could potentially lead to fundamental changes in radiation safety regulations...
  12. ncbi request reprint Methylation changes in muscle and liver tissues of male and female mice exposed to acute and chronic low-dose X-ray-irradiation
    Olga Kovalchuk
    Department of Biological Sciences, University of Lethbridge, 4401 University Drive, Lethbridge, Alta, Canada T1K 3M4
    Mutat Res 548:75-84. 2004
    ..This supports previous findings that chronic exposure leads to greater genome destabilization than acute exposure...
  13. ncbi request reprint Genome hypermethylation in Pinus silvestris of Chernobyl--a mechanism for radiation adaptation?
    Olga Kovalchuk
    Department of Biological Sciences, University of Lethbridge, 4401 University Drive, Lethbridge, Alta, Canada T1K 3M4
    Mutat Res 529:13-20. 2003
    ..Further studies are clearly needed to analyze in detail the involvement of DNA methylation and other epigenetic mechanisms in the complex process of radiation stress and adaptive response...
  14. ncbi request reprint Sex and tissue-specific differences in low-dose radiation-induced oncogenic signaling
    Jill Besplug
    Department of Biological Sciences, University of Lethbridge, Alberta, Canada
    Int J Radiat Biol 81:157-68. 2005
    ..Genes involved in oncogenic signaling were of specific interest, as radiation is a well-known carcinogen...
  15. ncbi request reprint Epigenetic dysregulation underlies radiation-induced transgenerational genome instability in vivo
    Igor Koturbash
    Department of Biological Sciences, University of Lethbridge, Lethbridge, AB, Canada
    Int J Radiat Oncol Biol Phys 66:327-30. 2006
    ..We hypothesized that epigenetic alterations may play a pivotal role in the molecular etiology of transgenerational genome instability...
  16. pmc Genomic instability in liver cells caused by an LPS-induced bystander-like effect
    Igor Kovalchuk
    Department of Biological Sciences, University of Lethbridge, Lethbridge, Canada
    PLoS ONE 8:e67342. 2013
    ..This study suggests that lipopolysaccharides are a major component of Gram-negative bacteria that induce molecular changes within naïve cells of the host. ..
  17. ncbi request reprint Novel retinoblastoma binding protein RBBP9 modulates sex-specific radiation responses in vivo
    Scott Cassie
    Department of Biological Sciences, University of Lethbridge, Lethbridge, Alberta, Canada
    Carcinogenesis 27:465-74. 2006
    ..The molecular mechanisms and possible repercussions of the radiation-induced sex differences in cellular proliferation and apoptosis are discussed...
  18. ncbi request reprint Paternal cranial irradiation induces distant bystander DNA damage in the germline and leads to epigenetic alterations in the offspring
    Jan Tamminga
    Department of Biological Sciences, University of Lethbridge, Alberta, Canada
    Cell Cycle 7:1238-45. 2008
    ....
  19. ncbi request reprint Sex-specific microRNAome deregulation in the shielded bystander spleen of cranially exposed mice
    Igor Koturbash
    Department of Biological Sciences, University of Lethbridge, Alberta, Canada
    Cell Cycle 7:1658-67. 2008
    ..Our data may provide a roadmap for further analysis of the role of microRNAome in genotoxic stress responses and may help us explain sex specificity of radiation-induced carcinogenesis...
  20. ncbi request reprint DNA damage-induced upregulation of miR-709 in the germline downregulates BORIS to counteract aberrant DNA hypomethylation
    Jan Tamminga
    Department of Biological Sciences, University of Lethbridge, Lethbridge, Alberta, Canada
    Cell Cycle 7:3731-6. 2008
    ....
  21. ncbi request reprint Hypomethylation and genome instability in the germline of exposed parents and their progeny is associated with altered miRNA expression
    Jody N Filkowski
    Department of Biological Sciences, University of Lethbridge, 4401 University of Lethbridge, Alberta, Canada T1K 3M4
    Carcinogenesis 31:1110-5. 2010
    ..In summary, altered microRNAome and hypomethylation of retroelements constitute deleterious effects that may significantly influence genome stability of the parental germline and consequently cause genome instability in the progeny...
  22. ncbi request reprint Transcriptome analysis reveals fundamental differences in plant response to acute and chronic exposure to ionizing radiation
    Igor Kovalchuk
    Department of Biological Sciences, University of Lethbridge, Lethbridge, Alta T1K 3M4, Canada
    Mutat Res 624:101-13. 2007
    ..Plants exposed to chronic but not acute radiation showed early flowering; transcriptome analysis also revealed induction of flowering genes in "chronic" group...
  23. ncbi request reprint Role of epigenetic effectors in maintenance of the long-term persistent bystander effect in spleen in vivo
    Igor Koturbash
    Department of Biological Sciences, University of Lethbridge, Alberta, T1K 3M4, Canada
    Carcinogenesis 28:1831-8. 2007
    ....
  24. ncbi request reprint Radiation-induced bystander effects in vivo are sex specific
    Igor Koturbash
    Department of Biological Sciences, University of Lethbridge, Alberta, Canada
    Mutat Res 642:28-36. 2008
    ..These data constitute the first evidence of sex differences in radiation-induced bystander effects in mouse spleen in vivo. We show the role of sex hormones in spleen bystander responses and discuss implications of the observed changes...
  25. ncbi request reprint Heat-killed bacteria induce genome instability in mouse small intestine, liver and spleen tissues
    Igor Koturbash
    Department of Biological Sciences, University of Lethbridge, Lethbridge, AB, Canada
    Cell Cycle 8:1935-9. 2009
    ..Even though bacteria were non-pathogenic and unable to cause infection, their remnants still caused a profound effect on exposed animals...
  26. pmc Molecular aspects of plant adaptation to life in the Chernobyl zone
    Igor Kovalchuk
    Department of Biological Sciences, University of Lethbridge, Lethbridge, Alberta, Canada T1K 3M4
    Plant Physiol 135:357-63. 2004
    ..This data suggests that adaptation to ionizing radiation is a complex process involving epigenetic regulation of gene expression and genome stabilization that improves plants' resistance to environmental mutagens...
  27. ncbi request reprint Sex- and tissue-specific expression of maintenance and de novo DNA methyltransferases upon low dose X-irradiation in mice
    Joe Raiche
    Department of Biological Sciences, University of Lethbridge, 4401 University Drive, Lethbridge, Alta, Canada T1K 3M4
    Biochem Biophys Res Commun 325:39-47. 2004
    ..We also discuss the role of sex hormones, especially estrogen, in the generation of the sex-specific radiation-induced methylation changes...
  28. ncbi request reprint Genome stability of vtc1, tt4, and tt5 Arabidopsis thaliana mutants impaired in protection against oxidative stress
    Jody Filkowski
    Department of Biological Sciences, University of Lethbridge, Lethbridge, Alta, Canada T1K 3M4
    Plant J 38:60-9. 2004
    ....
  29. doi request reprint Altered microRNA expression patterns in irradiated hematopoietic tissues suggest a sex-specific protective mechanism
    Yaroslav Ilnytskyy
    Department of Biological Sciences, University of Lethbridge, Lethbridge, Alta, Canada
    Biochem Biophys Res Commun 377:41-5. 2008
    ..These cellular changes may constitute an attempt to counteract radiation-induced hypomethylation. Tissue specificity of miRNA responses and possible regulation of miRNA expression upon irradiation are discussed...
  30. doi request reprint In vivo bystander effect: cranial X-irradiation leads to elevated DNA damage, altered cellular proliferation and apoptosis, and increased p53 levels in shielded spleen
    Igor Koturbash
    Department of Biological Sciences, University of Lethbridge, Alberta, Canada
    Int J Radiat Oncol Biol Phys 70:554-62. 2008
    ..Although bystander effects were well studied by using cell cultures, data for somatic bystander effects in vivo are relatively scarce...
  31. ncbi request reprint Radiation-induced molecular changes in rat mammary tissue: possible implications for radiation-induced carcinogenesis
    Jonathan Loree
    Department of Biological Sciences, University of Lethbridge, Lethbridge, Alberta, Canada
    Int J Radiat Biol 82:805-15. 2006
    ..Ionizing radiation is a potent mammary gland carcinogen, yet the exact molecular etiology of radiation-induced breast cancer remains unknown...
  32. ncbi request reprint Selective brain responses to acute and chronic low-dose X-ray irradiation in males and females
    Greg Silasi
    Department of Psychology and Neuroscience, University of Lethbridge, Lethbridge, Alta, Canada T1K 3M4
    Biochem Biophys Res Commun 325:1223-35. 2004
    ..We also present the first evidence of sex differences in radiation-induced signaling in the hippocampus and frontal cortex. We show the role of estrogens in brain radiation responses and discuss the implications of the observed changes...
  33. ncbi request reprint Systemic plant signal triggers genome instability
    Jody Filkowski
    Department of Biological Sciences, University of Lethbridge, Lethbridge, Alta, Canada T1K 3M4
    Plant J 38:1-11. 2004
    ..We discuss potential mechanisms for generation of the signal and possible adaptive advantages of enhanced genomic flexibility following exposure to DNA-damaging agents...
  34. doi request reprint Sex-specific radiation-induced microRNAome responses in the hippocampus, cerebellum and frontal cortex in a mouse model
    Igor Koturbash
    Department of Biological Sciences, University of Lethbridge, Lethbridge, AB, Canada
    Mutat Res 722:114-8. 2011
    ..In summary, our study may provide an important roadmap for further analysis of microRNA expression in different brain regions of male and female mice and for detailed dissection of radiation-induced brain responses...
  35. ncbi request reprint Atrazine induces homologous recombination but not point mutation in the transgenic plant-based biomonitoring assay
    Jill Besplug
    Department of Biological Sciences, University of Lethbridge, Lethbridge, Alberta, T1K 3M4, Canada
    Arch Environ Contam Toxicol 46:296-300. 2004
    ..In the future this system can be used to study molecular mechanisms of genotoxicity and mutagenicity atrazine and other triazine herbicides...
  36. pmc Crucial role for early growth response-1 in the transcriptional regulation of miR-20b in breast cancer
    Dongping Li
    Department of Biological Sciences, University of Lethbridge, Lethbridge, Canada
    Oncotarget 4:1373-87. 2013
    ....
  37. doi request reprint The increased expression of proteins involved in proliferation, DNA repair and DNA methylation in spleen of mice exposed to E. coli O157:H7 lipopolysaccharide
    Igor Kovalchuk
    Department of Biological Sciences, University of Lethbridge, 4401 University Drive, Lethbridge, T1K 3M4, Canada
    Environ Mol Mutagen 54:421-8. 2013
    ..Other bacterial components analysed in this study mostly did not alter protein expression. The data suggest that LPS is a bacterial component capable of inducing molecular changes in naïve spleen cells of hosts exposed to it...
  38. doi request reprint Reversibility of pre-malignant estrogen-induced epigenetic changes
    Kristy R Kutanzi
    Department of Biological Sciences, University of Lethbridge, Lethbridge, AB, Canada
    Cell Cycle 9:3078-84. 2010
    ....
  39. doi request reprint Molecular mechanisms of radiation resistance in doxorubicin-resistant breast adenocarcinoma cells
    Lidia Luzhna
    Department of Biological Sciences, University of Lethbridge, Lethbridge, AB T1K3M4, Canada
    Int J Oncol 42:1692-708. 2013
    ..Therefore, this study provides a roadmap for the analysis of the roles of the DNA repair function and effectiveness, and apoptosis in response to radiation, chemotherapy and combinations of both treatment modalities...
  40. ncbi request reprint Role of DNA damage and epigenetic DNA methylation changes in radiation-induced genomic instability and bystander effects in germline in vivo
    Jan Tamminga
    Department of Biological Sciences, University of Lethbridge, Alberta, Canada
    Curr Mol Pharmacol 4:115-25. 2011
    ..The possible molecular mechanisms and biological consequences of the observed changes are discussed...
  41. pmc Exposure to estrogen and ionizing radiation causes epigenetic dysregulation, activation of mitogen-activated protein kinase pathways, and genome instability in the mammary gland of ACI rats
    Kristy Kutanzi
    Department of Biological Sciences, University of Lethbridge, Lethbridge, AB, Canada
    Cancer Biol Ther 14:564-73. 2013
    ..The precise role of MAPK pathways and their inter-relationship with H3S10 phosphorylation and genome instability in mammary gland tissues needs to be explored further. ..
  42. doi request reprint Parental enrichment and offspring development: modifications to brain, behavior and the epigenome
    Richelle Mychasiuk
    University of Lethbridge, Canadian Centre for Behavioural Neuroscience, Canada
    Behav Brain Res 228:294-8. 2012
    ..This study demonstrates that positive prenatal experiences; preconceptionally in fathers and prenatally in mothers, have the ability to significantly alter offspring developmental trajectories...
  43. doi request reprint Modulation of DNA methylation levels sensitizes doxorubicin-resistant breast adenocarcinoma cells to radiation-induced apoptosis
    Lidia Luzhna
    Department of Biological Sciences, University of Lethbridge, AB T1K3M4, Canada
    Biochem Biophys Res Commun 392:113-7. 2010
    ..This data suggests that a fine balance of DNA methylation is needed to insure proper radiation and drug responsiveness...
  44. ncbi request reprint Genotoxicity of 2,4-D and dicamba revealed by transgenic Arabidopsis thaliana plants harboring recombination and point mutation markers
    Jody Filkowski
    Department of Biological Sciences, University of Lethbridge, Lethbridge, AB, Canada T1K 3M4
    Mutat Res 542:23-32. 2003
    ....
  45. pmc p53 Ser15 phosphorylation and histone modifications contribute to IR-induced miR-34a transcription in mammary epithelial cells
    Bo Wang
    Department of Biological Sciences, University of Lethbridge, Lethbridge, AB Canada
    Cell Cycle 12:2073-83. 2013
    ....
  46. doi request reprint Small molecules with big effects: the role of the microRNAome in cancer and carcinogenesis
    Igor Koturbash
    Department of Biological Sciences, University of Lethbridge, AB, Canada
    Mutat Res 722:94-105. 2011
    ..This review focuses on microRNA biogenesis and function, and their role in cancer, metastasis, drug resistance, and tumorigenesis...
  47. pmc Intense THz pulses down-regulate genes associated with skin cancer and psoriasis: a new therapeutic avenue?
    Lyubov V Titova
    Department of Physics, University of Alberta, Edmonton, Alberta, Canada
    Sci Rep 3:2363. 2013
    ..The ability of intense THz pulses to cause concerted favorable changes in the expression of multiple genes implicated in inflammatory skin diseases and skin cancers suggests potential therapeutic applications of intense THz pulses. ..
  48. doi request reprint Prenatal bystander stress alters brain, behavior, and the epigenome of developing rat offspring
    Richelle Mychasiuk
    Canadian Centre for Behavioural Neurosciences, University of Lethbridge, Lethbridge, Alta, Canada
    Dev Neurosci 33:159-69. 2011
    ..Furthermore, this type of 'indirect' prenatal stress alters offspring DNA methylation patterns, gene expression profiles, and behavior...
  49. ncbi request reprint Stable loss of global DNA methylation in the radiation-target tissue--a possible mechanism contributing to radiation carcinogenesis?
    Igor Koturbash
    Department of Biological Sciences, University of Lethbridge, Alta, Canada
    Biochem Biophys Res Commun 337:526-33. 2005
    ..The possible role of radiation-induced DNA hypomethylation in radiation-induced genome instability and aberrant gene expression in molecular etiology of thymic lymphomas is discussed...
  50. pmc Maternal stress induces epigenetic signatures of psychiatric and neurological diseases in the offspring
    Fabiola C R Zucchi
    Department of Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada
    PLoS ONE 8:e56967. 2013
    ..These observations provide a new mechanistic association between environmental and genetic risk factors in psychiatric and neurological disease...
  51. pmc Lifetime stress cumulatively programs brain transcriptome and impedes stroke recovery: benefit of sensory stimulation
    Fabiola C R Zucchi
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada Departments of Medicine and Biological Sciences, University of Mato Grosso State, Caceres, MT, Brazil
    PLoS ONE 9:e92130. 2014
    ..These findings suggest that beneficial experience later in life can moderate adverse consequences of early programming to improve cerebrovascular health. ..
  52. ncbi request reprint High frequency of nucleotide misincorporations upon the processing of double-strand breaks
    Igor Kovalchuk
    Department of Biological Sciences, University of Lethbridge, Lethbridge, Alta, Canada, T1K 3M4
    DNA Repair (Amst) 3:217-23. 2004
    ..The data suggest that the error prone processing of the free ends involves partial degradation and re-synthesis of the DNA repair substrate...
  53. ncbi request reprint Transcriptome profiling reveals similarities and differences in plant responses to cadmium and lead
    Igor Kovalchuk
    Department of Biological Sciences, University of Lethbridge, Alta, Canada T1K 3M4
    Mutat Res 570:149-61. 2005
    ..The greater number of genes regulated by Cd reflects generally higher genome instability of plants as well as higher uptake as compared to Pb...
  54. doi request reprint Imbalance between apoptosis and cell proliferation during early stages of mammary gland carcinogenesis in ACI rats
    Kristy R Kutanzi
    Department of Biological Sciences, University of Lethbridge, Lethbridge, AB, T1K3M4 Canada
    Mutat Res 694:1-6. 2010
    ....
  55. ncbi request reprint A new use for transgenic plants--environmental biomonitors
    Igor Kovalchuk
    Department of Biological Sciences, University of Lethbridge, Lethbridge, Alberta T1K 3M4, Canada
    Biotechnol Genet Eng Rev 20:23-45. 2003
  56. doi request reprint Non-targeted radiation effects-an epigenetic connection
    Yaroslav Ilnytskyy
    Department of Biological Sciences, University of Lethbridge, Lethbridge T1K 3M4, Alberta, Canada
    Mutat Res 714:113-25. 2011
    ..Here, we present evidence that IR-mediated effects are maintained by epigenetic mechanisms...
  57. ncbi request reprint In vivo recombination after chronic damage exposure falls to below spontaneous levels in "recombomice"
    Olga Kovalchuk
    Department of Biological Sciences, University of Lethbridge, Lethbridge, Alberta, Canada
    Mol Cancer Res 2:567-73. 2004
    ....
  58. doi request reprint Monte Carlo-based dose reconstruction in a rat model for scattered ionizing radiation investigations
    Charles Kirkby
    Department of Medical Physics, Jack Ady Cancer Centre, Lethbridge, Alberta, Canada
    Int J Radiat Biol 89:741-9. 2013
    ..We used a non-dedicated set of resources to calculate detailed dose distributions, including doses to peripheral organs well outside of the primary field, in common rat exposure settings...
  59. ncbi request reprint Pathogen-induced systemic plant signal triggers DNA rearrangements
    Igor Kovalchuk
    Department of Biological Sciences, University of Lethbridge, Lethbridge, Alberta T1K 3M4, Canada
    Nature 423:760-2. 2003
    ..These results indicate the existence of a systemic recombination signal that also results in an increased frequency of meiotic and/or inherited late somatic recombination...
  60. doi request reprint Epigenetics and miRNAs in the diagnosis and treatment of multiple sclerosis
    Marcus W Koch
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    Trends Mol Med 19:23-30. 2013
    ..We also discuss how the current studies address important clinical questions and how future studies could be designed to best inform clinical practice...
  61. ncbi request reprint Dose-dependence, sex- and tissue-specificity, and persistence of radiation-induced genomic DNA methylation changes
    Igor Pogribny
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Biochem Biophys Res Commun 320:1253-61. 2004
    ..Based on the correlation between the levels of DNA methylation and DNA damage we propose that radiation-induced global genome DNA hypomethylation is DNA repair-related...
  62. ncbi request reprint Induction of microRNAome deregulation in rat liver by long-term tamoxifen exposure
    Igor P Pogribny
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, United States
    Mutat Res 619:30-7. 2007
    ..Thus, our findings indicate that miRNA changes occur prior to tumor formation and are not merely a consequence of a transformed state...
  63. ncbi request reprint Epigenetic profiling of multidrug-resistant human MCF-7 breast adenocarcinoma cells reveals novel hyper- and hypomethylated targets
    Nataliya Yu Lukyanova
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Mol Cancer Ther 6:1089-98. 2007
    ..Finally, deregulation of similar pathways may explain the existence and provide mechanism of cross-resistance of cancer cells to different types of chemotherapeutic agents...
  64. ncbi request reprint DNA double-strand breaks form in bystander cells after microbeam irradiation of three-dimensional human tissue models
    Olga A Sedelnikova
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 67:4295-302. 2007
    ..Thus, this study points to the importance of considering the indirect biological effects of radiation in cancer risk assessment...
  65. ncbi request reprint Identification of differentially methylated sites within unmethylated DNA domains in normal and cancer cells
    Volodymyr Tryndyak
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Anal Biochem 356:202-7. 2006
    ....
  66. ncbi request reprint Effect of long-term tamoxifen exposure on genotoxic and epigenetic changes in rat liver: implications for tamoxifen-induced hepatocarcinogenesis
    Volodymyr P Tryndyak
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Carcinogenesis 27:1713-20. 2006
    ..These data indicate the importance of genotoxic and epigenetic alterations in the etiology of tamoxifen-induced hepatocarcinogenesis...
  67. ncbi request reprint Gene expression profiling reveals underlying molecular mechanisms of the early stages of tamoxifen-induced rat hepatocarcinogenesis
    Igor P Pogribny
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Toxicol Appl Pharmacol 225:61-9. 2007
    ..The early appearance of these alterations suggests their importance in the mechanism of neoplastic cell transformation induced by tamoxifen...
  68. doi request reprint Epigenetic research sheds new light on the nature of interactions between organisms and their environment
    Olga Kovalchuk
    Environ Mol Mutagen 49:1-3. 2008
  69. ncbi request reprint Loss of DNA methylation and histone H4 lysine 20 trimethylation in human breast cancer cells is associated with aberrant expression of DNA methyltransferase 1, Suv4-20h2 histone methyltransferase and methyl-binding proteins
    Volodymyr P Tryndyak
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AK 72079, USA
    Cancer Biol Ther 5:65-70. 2006
    ..Such epigenetic dysregulation may contribute to and may be indicative of the formation of a more aggressive tumor phenotype during tumor progression...
  70. pmc Germ-line mutations, DNA damage, and global hypermethylation in mice exposed to particulate air pollution in an urban/industrial location
    Carole Yauk
    Environmental and Occupational Toxicology Division, HECSB, Ottawa, ON, Canada K1A 0K9
    Proc Natl Acad Sci U S A 105:605-10. 2008
    ..Changes in methylation can have widespread repercussions for chromatin structure, gene expression and genome stability. Potential health effects warrant extensive further investigation...
  71. ncbi request reprint Fractionated low-dose radiation exposure leads to accumulation of DNA damage and profound alterations in DNA and histone methylation in the murine thymus
    Igor Pogribny
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas, USA
    Mol Cancer Res 3:553-61. 2005
    ..Our results show the involvement of epigenetic alterations in radiation-induced responses in vivo. These changes may play a role in genome destabilization that ultimately leads to cancer...
  72. ncbi request reprint Epigenetic reprogramming of liver cells in tamoxifen-induced rat hepatocarcinogenesis
    Volodymyr P Tryndyak
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Mol Carcinog 46:187-97. 2007
    ....
  73. doi request reprint Tandem repeat mutation, global DNA methylation, and regulation of DNA methyltransferases in cultured mouse embryonic fibroblast cells chronically exposed to chemicals with different modes of action
    Carole L Yauk
    Environmental Health Sciences and Research Bureau, Safe Environments Programme, Health Canada, Ottawa, Ontario, Canada
    Environ Mol Mutagen 49:26-35. 2008
    ....