Olga Kovalchuk

Summary

Affiliation: University of Lethbridge
Country: Canada

Publications

  1. ncbi Estrogen-induced rat breast carcinogenesis is characterized by alterations in DNA methylation, histone modifications and aberrant microRNA expression
    Olga Kovalchuk
    Department of Biological Sciences, University of Lethbridge, Lethbridge, Canada
    Cell Cycle 6:2010-8. 2007
  2. ncbi Radiation-induced bystander effects in vivo are epigenetically regulated in a tissue-specific manner
    Yaroslav Ilnytskyy
    Department of Biological Sciences, University of Lethbridge, Alberta, Canada
    Environ Mol Mutagen 50:105-13. 2009
  3. ncbi Extremely complex pattern of microsatellite mutation in the germline of wheat exposed to the post-Chernobyl radioactive contamination
    Olga Kovalchuk
    Friedrich Miescher Institute, Novartis Research Foundation, PO Box 2543, CH 4002 Basel, Switzerland
    Mutat Res 525:93-101. 2003
  4. ncbi Epigenetic changes and nontargeted radiation effects--is there a link?
    Olga Kovalchuk
    Department of Biological Sciences, University of Lethbridge, Alberta, Canada
    Environ Mol Mutagen 49:16-25. 2008
  5. ncbi Dissimilar genome response to acute and chronic low-dose radiation in male and female mice
    Olga Kovalchuk
    Department of Biological Sciences, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, Canada T1K 3M4
    Mutat Res 550:59-72. 2004
  6. ncbi Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin
    Olga Kovalchuk
    Department of Biological Sciences, University of Lethbridge, Lethbridge, Alberta, Canada T1K 3M4
    Mol Cancer Ther 7:2152-9. 2008
  7. ncbi Methylation changes in muscle and liver tissues of male and female mice exposed to acute and chronic low-dose X-ray-irradiation
    Olga Kovalchuk
    Department of Biological Sciences, University of Lethbridge, 4401 University Drive, Lethbridge, Alta, Canada T1K 3M4
    Mutat Res 548:75-84. 2004
  8. ncbi Genome hypermethylation in Pinus silvestris of Chernobyl--a mechanism for radiation adaptation?
    Olga Kovalchuk
    Department of Biological Sciences, University of Lethbridge, 4401 University Drive, Lethbridge, Alta, Canada T1K 3M4
    Mutat Res 529:13-20. 2003
  9. ncbi microRNAome changes in bystander three-dimensional human tissue models suggest priming of apoptotic pathways
    Olga Kovalchuk
    Department of Biological Sciences, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, T1K 3M4 Canada
    Carcinogenesis 31:1882-8. 2010
  10. ncbi Epigenetic dysregulation underlies radiation-induced transgenerational genome instability in vivo
    Igor Koturbash
    Department of Biological Sciences, University of Lethbridge, Lethbridge, AB, Canada
    Int J Radiat Oncol Biol Phys 66:327-30. 2006

Collaborators

Detail Information

Publications62

  1. ncbi Estrogen-induced rat breast carcinogenesis is characterized by alterations in DNA methylation, histone modifications and aberrant microRNA expression
    Olga Kovalchuk
    Department of Biological Sciences, University of Lethbridge, Lethbridge, Canada
    Cell Cycle 6:2010-8. 2007
    ..The results of this study show that deregulation of cellular epigenetic processes plays a crucial role in the mechanism of E(2)-induced mammary carcinogenesis in ACI rats, especially in the tumor initiation process...
  2. ncbi Radiation-induced bystander effects in vivo are epigenetically regulated in a tissue-specific manner
    Yaroslav Ilnytskyy
    Department of Biological Sciences, University of Lethbridge, Alberta, Canada
    Environ Mol Mutagen 50:105-13. 2009
    ..Future studies are clearly needed to address organismal and carcinogenic repercussions of those changes...
  3. ncbi Extremely complex pattern of microsatellite mutation in the germline of wheat exposed to the post-Chernobyl radioactive contamination
    Olga Kovalchuk
    Friedrich Miescher Institute, Novartis Research Foundation, PO Box 2543, CH 4002 Basel, Switzerland
    Mutat Res 525:93-101. 2003
    ..Our data also support the conclusion that the spectra of spontaneous and radiation-induced mutation in wheat may be similar...
  4. ncbi Epigenetic changes and nontargeted radiation effects--is there a link?
    Olga Kovalchuk
    Department of Biological Sciences, University of Lethbridge, Alberta, Canada
    Environ Mol Mutagen 49:16-25. 2008
    ..Transgeneration radiation effects were also proposed to be of an epigenetic nature. We will discuss the role of the epigenetic mechanisms in radiation responses, bystander effects, and transgeneration effects...
  5. ncbi Dissimilar genome response to acute and chronic low-dose radiation in male and female mice
    Olga Kovalchuk
    Department of Biological Sciences, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, Canada T1K 3M4
    Mutat Res 550:59-72. 2004
    ..If confirmed in other experimental systems, these findings could potentially lead to fundamental changes in radiation safety regulations...
  6. ncbi Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin
    Olga Kovalchuk
    Department of Biological Sciences, University of Lethbridge, Lethbridge, Alberta, Canada T1K 3M4
    Mol Cancer Ther 7:2152-9. 2008
    ....
  7. ncbi Methylation changes in muscle and liver tissues of male and female mice exposed to acute and chronic low-dose X-ray-irradiation
    Olga Kovalchuk
    Department of Biological Sciences, University of Lethbridge, 4401 University Drive, Lethbridge, Alta, Canada T1K 3M4
    Mutat Res 548:75-84. 2004
    ..This supports previous findings that chronic exposure leads to greater genome destabilization than acute exposure...
  8. ncbi Genome hypermethylation in Pinus silvestris of Chernobyl--a mechanism for radiation adaptation?
    Olga Kovalchuk
    Department of Biological Sciences, University of Lethbridge, 4401 University Drive, Lethbridge, Alta, Canada T1K 3M4
    Mutat Res 529:13-20. 2003
    ..Further studies are clearly needed to analyze in detail the involvement of DNA methylation and other epigenetic mechanisms in the complex process of radiation stress and adaptive response...
  9. ncbi microRNAome changes in bystander three-dimensional human tissue models suggest priming of apoptotic pathways
    Olga Kovalchuk
    Department of Biological Sciences, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, T1K 3M4 Canada
    Carcinogenesis 31:1882-8. 2010
    ..In summary, this study creates a roadmap for understanding the role of microRNAome in RIBE and for developing novel RIBE biomarkers...
  10. ncbi Epigenetic dysregulation underlies radiation-induced transgenerational genome instability in vivo
    Igor Koturbash
    Department of Biological Sciences, University of Lethbridge, Lethbridge, AB, Canada
    Int J Radiat Oncol Biol Phys 66:327-30. 2006
    ..Future studies are clearly needed to address the cellular and carcinogenic repercussions of those changes...
  11. ncbi Sex and tissue-specific differences in low-dose radiation-induced oncogenic signaling
    Jill Besplug
    Department of Biological Sciences, University of Lethbridge, Alberta, Canada
    Int J Radiat Biol 81:157-68. 2005
    ..From our results we could identify the genes that may serve as sex- and tissue-specific biomarkers of the LDR exposure...
  12. ncbi Sex-specific microRNAome deregulation in the shielded bystander spleen of cranially exposed mice
    Igor Koturbash
    Department of Biological Sciences, University of Lethbridge, Alberta, Canada
    Cell Cycle 7:1658-67. 2008
    ..Our data may provide a roadmap for further analysis of the role of microRNAome in genotoxic stress responses and may help us explain sex specificity of radiation-induced carcinogenesis...
  13. ncbi Paternal cranial irradiation induces distant bystander DNA damage in the germline and leads to epigenetic alterations in the offspring
    Jan Tamminga
    Department of Biological Sciences, University of Lethbridge, Alberta, Canada
    Cell Cycle 7:1238-45. 2008
    ....
  14. ncbi Hypomethylation and genome instability in the germline of exposed parents and their progeny is associated with altered miRNA expression
    Jody N Filkowski
    Department of Biological Sciences, University of Lethbridge, 4401 University of Lethbridge, Alberta, Canada T1K 3M4
    Carcinogenesis 31:1110-5. 2010
    ..In summary, altered microRNAome and hypomethylation of retroelements constitute deleterious effects that may significantly influence genome stability of the parental germline and consequently cause genome instability in the progeny...
  15. ncbi DNA damage-induced upregulation of miR-709 in the germline downregulates BORIS to counteract aberrant DNA hypomethylation
    Jan Tamminga
    Department of Biological Sciences, University of Lethbridge, Lethbridge, Alberta, Canada
    Cell Cycle 7:3731-6. 2008
    ....
  16. ncbi Epigenetic bystander-like effects of stroke in somatic organs
    Anna Kovalchuk
    Department of Biology, University of Lethbridge, Lethbridge, Alberta
    Aging (Albany NY) 4:224-34. 2012
    ....
  17. ncbi Transcriptome analysis reveals fundamental differences in plant response to acute and chronic exposure to ionizing radiation
    Igor Kovalchuk
    Department of Biological Sciences, University of Lethbridge, Lethbridge, Alta T1K 3M4, Canada
    Mutat Res 624:101-13. 2007
    ..Plants exposed to chronic but not acute radiation showed early flowering; transcriptome analysis also revealed induction of flowering genes in "chronic" group...
  18. ncbi Role of epigenetic effectors in maintenance of the long-term persistent bystander effect in spleen in vivo
    Igor Koturbash
    Department of Biological Sciences, University of Lethbridge, Alberta, T1K 3M4, Canada
    Carcinogenesis 28:1831-8. 2007
    ....
  19. ncbi Heat-killed bacteria induce genome instability in mouse small intestine, liver and spleen tissues
    Igor Koturbash
    Department of Biological Sciences, University of Lethbridge, Lethbridge, AB, Canada
    Cell Cycle 8:1935-9. 2009
    ..Even though bacteria were non-pathogenic and unable to cause infection, their remnants still caused a profound effect on exposed animals...
  20. ncbi Novel retinoblastoma binding protein RBBP9 modulates sex-specific radiation responses in vivo
    Scott Cassie
    Department of Biological Sciences, University of Lethbridge, Lethbridge, Alberta, Canada
    Carcinogenesis 27:465-74. 2006
    ..The molecular mechanisms and possible repercussions of the radiation-induced sex differences in cellular proliferation and apoptosis are discussed...
  21. ncbi Radiation-induced bystander effects in vivo are sex specific
    Igor Koturbash
    Department of Biological Sciences, University of Lethbridge, Alberta, Canada
    Mutat Res 642:28-36. 2008
    ..These data constitute the first evidence of sex differences in radiation-induced bystander effects in mouse spleen in vivo. We show the role of sex hormones in spleen bystander responses and discuss implications of the observed changes...
  22. ncbi Molecular aspects of plant adaptation to life in the Chernobyl zone
    Igor Kovalchuk
    Department of Biological Sciences, University of Lethbridge, Lethbridge, Alberta, Canada T1K 3M4
    Plant Physiol 135:357-63. 2004
    ..This data suggests that adaptation to ionizing radiation is a complex process involving epigenetic regulation of gene expression and genome stabilization that improves plants' resistance to environmental mutagens...
  23. ncbi Genome stability of vtc1, tt4, and tt5 Arabidopsis thaliana mutants impaired in protection against oxidative stress
    Jody Filkowski
    Department of Biological Sciences, University of Lethbridge, Lethbridge, Alta, Canada T1K 3M4
    Plant J 38:60-9. 2004
    ....
  24. ncbi Altered microRNA expression patterns in irradiated hematopoietic tissues suggest a sex-specific protective mechanism
    Yaroslav Ilnytskyy
    Department of Biological Sciences, University of Lethbridge, Lethbridge, Alta, Canada
    Biochem Biophys Res Commun 377:41-5. 2008
    ..These cellular changes may constitute an attempt to counteract radiation-induced hypomethylation. Tissue specificity of miRNA responses and possible regulation of miRNA expression upon irradiation are discussed...
  25. ncbi Radiation-induced molecular changes in rat mammary tissue: possible implications for radiation-induced carcinogenesis
    Jonathan Loree
    Department of Biological Sciences, University of Lethbridge, Lethbridge, Alberta, Canada
    Int J Radiat Biol 82:805-15. 2006
    ..Ionizing radiation is a potent mammary gland carcinogen, yet the exact molecular etiology of radiation-induced breast cancer remains unknown...
  26. ncbi Induction and persistence of radiation-induced DNA damage is more pronounced in young animals than in old animals
    Darryl Hudson
    Department of Biological Sciences, University of Lethbridge, Lethbridge, AB, T1K 3M4 Canada
    Aging (Albany NY) 3:609-20. 2011
    ..The mechanisms of cell and tissue-specificity of in vivo IR responses need to be further dissected. This study provides a roadmap for the future analyses of DNA damage and repair induction in young individuals...
  27. ncbi In vivo bystander effect: cranial X-irradiation leads to elevated DNA damage, altered cellular proliferation and apoptosis, and increased p53 levels in shielded spleen
    Igor Koturbash
    Department of Biological Sciences, University of Lethbridge, Alberta, Canada
    Int J Radiat Oncol Biol Phys 70:554-62. 2008
    ..Although bystander effects were well studied by using cell cultures, data for somatic bystander effects in vivo are relatively scarce...
  28. ncbi Sex-specific radiation-induced microRNAome responses in the hippocampus, cerebellum and frontal cortex in a mouse model
    Igor Koturbash
    Department of Biological Sciences, University of Lethbridge, Lethbridge, AB, Canada
    Mutat Res 722:114-8. 2011
    ..In summary, our study may provide an important roadmap for further analysis of microRNA expression in different brain regions of male and female mice and for detailed dissection of radiation-induced brain responses...
  29. ncbi Sex- and tissue-specific expression of maintenance and de novo DNA methyltransferases upon low dose X-irradiation in mice
    Joe Raiche
    Department of Biological Sciences, University of Lethbridge, 4401 University Drive, Lethbridge, Alta, Canada T1K 3M4
    Biochem Biophys Res Commun 325:39-47. 2004
    ..We also discuss the role of sex hormones, especially estrogen, in the generation of the sex-specific radiation-induced methylation changes...
  30. ncbi Atrazine induces homologous recombination but not point mutation in the transgenic plant-based biomonitoring assay
    Jill Besplug
    Department of Biological Sciences, University of Lethbridge, Lethbridge, Alberta, T1K 3M4, Canada
    Arch Environ Contam Toxicol 46:296-300. 2004
    ..In the future this system can be used to study molecular mechanisms of genotoxicity and mutagenicity atrazine and other triazine herbicides...
  31. ncbi Role of DNA damage and epigenetic DNA methylation changes in radiation-induced genomic instability and bystander effects in germline in vivo
    Jan Tamminga
    Department of Biological Sciences, University of Lethbridge, Alberta, Canada
    Curr Mol Pharmacol 4:115-25. 2011
    ..The possible molecular mechanisms and biological consequences of the observed changes are discussed...
  32. ncbi Systemic plant signal triggers genome instability
    Jody Filkowski
    Department of Biological Sciences, University of Lethbridge, Lethbridge, Alta, Canada T1K 3M4
    Plant J 38:1-11. 2004
    ..We discuss potential mechanisms for generation of the signal and possible adaptive advantages of enhanced genomic flexibility following exposure to DNA-damaging agents...
  33. ncbi Parental enrichment and offspring development: modifications to brain, behavior and the epigenome
    Richelle Mychasiuk
    University of Lethbridge, Canadian Centre for Behavioural Neuroscience, Canada
    Behav Brain Res 228:294-8. 2012
    ..This study demonstrates that positive prenatal experiences; preconceptionally in fathers and prenatally in mothers, have the ability to significantly alter offspring developmental trajectories...
  34. ncbi Modulation of DNA methylation levels sensitizes doxorubicin-resistant breast adenocarcinoma cells to radiation-induced apoptosis
    Lidia Luzhna
    Department of Biological Sciences, University of Lethbridge, AB T1K3M4, Canada
    Biochem Biophys Res Commun 392:113-7. 2010
    ..This data suggests that a fine balance of DNA methylation is needed to insure proper radiation and drug responsiveness...
  35. ncbi Selective brain responses to acute and chronic low-dose X-ray irradiation in males and females
    Greg Silasi
    Department of Psychology and Neuroscience, University of Lethbridge, Lethbridge, Alta, Canada T1K 3M4
    Biochem Biophys Res Commun 325:1223-35. 2004
    ..We also present the first evidence of sex differences in radiation-induced signaling in the hippocampus and frontal cortex. We show the role of estrogens in brain radiation responses and discuss the implications of the observed changes...
  36. ncbi Genotoxicity of 2,4-D and dicamba revealed by transgenic Arabidopsis thaliana plants harboring recombination and point mutation markers
    Jody Filkowski
    Department of Biological Sciences, University of Lethbridge, Lethbridge, AB, Canada T1K 3M4
    Mutat Res 542:23-32. 2003
    ....
  37. ncbi Reversibility of pre-malignant estrogen-induced epigenetic changes
    Kristy R Kutanzi
    Department of Biological Sciences, University of Lethbridge, Lethbridge, AB, Canada
    Cell Cycle 9:3078-84. 2010
    ....
  38. ncbi Prenatal bystander stress alters brain, behavior, and the epigenome of developing rat offspring
    Richelle Mychasiuk
    Canadian Centre for Behavioural Neurosciences, University of Lethbridge, Lethbridge, Alta, Canada
    Dev Neurosci 33:159-69. 2011
    ..Furthermore, this type of 'indirect' prenatal stress alters offspring DNA methylation patterns, gene expression profiles, and behavior...
  39. ncbi High frequency of nucleotide misincorporations upon the processing of double-strand breaks
    Igor Kovalchuk
    Department of Biological Sciences, University of Lethbridge, Lethbridge, Alta, Canada, T1K 3M4
    DNA Repair (Amst) 3:217-23. 2004
    ..The data suggest that the error prone processing of the free ends involves partial degradation and re-synthesis of the DNA repair substrate...
  40. ncbi Small molecules with big effects: the role of the microRNAome in cancer and carcinogenesis
    Igor Koturbash
    Department of Biological Sciences, University of Lethbridge, AB, Canada
    Mutat Res 722:94-105. 2011
    ..This review focuses on microRNA biogenesis and function, and their role in cancer, metastasis, drug resistance, and tumorigenesis...
  41. ncbi Stable loss of global DNA methylation in the radiation-target tissue--a possible mechanism contributing to radiation carcinogenesis?
    Igor Koturbash
    Department of Biological Sciences, University of Lethbridge, Alta, Canada
    Biochem Biophys Res Commun 337:526-33. 2005
    ..The possible role of radiation-induced DNA hypomethylation in radiation-induced genome instability and aberrant gene expression in molecular etiology of thymic lymphomas is discussed...
  42. ncbi Transcriptome profiling reveals similarities and differences in plant responses to cadmium and lead
    Igor Kovalchuk
    Department of Biological Sciences, University of Lethbridge, Alta, Canada T1K 3M4
    Mutat Res 570:149-61. 2005
    ..The greater number of genes regulated by Cd reflects generally higher genome instability of plants as well as higher uptake as compared to Pb...
  43. ncbi Molecular mechanisms of radiation resistance in doxorubicin-resistant breast adenocarcinoma cells
    Lidia Luzhna
    Department of Biological Sciences, University of Lethbridge, Lethbridge, AB T1K3M4, Canada
    Int J Oncol 42:1692-708. 2013
    ..Therefore, this study provides a roadmap for the analysis of the roles of the DNA repair function and effectiveness, and apoptosis in response to radiation, chemotherapy and combinations of both treatment modalities...
  44. ncbi Non-targeted radiation effects-an epigenetic connection
    Yaroslav Ilnytskyy
    Department of Biological Sciences, University of Lethbridge, Lethbridge T1K 3M4, Alberta, Canada
    Mutat Res 714:113-25. 2011
    ..Here, we present evidence that IR-mediated effects are maintained by epigenetic mechanisms...
  45. ncbi Imbalance between apoptosis and cell proliferation during early stages of mammary gland carcinogenesis in ACI rats
    Kristy R Kutanzi
    Department of Biological Sciences, University of Lethbridge, Lethbridge, AB, T1K3M4 Canada
    Mutat Res 694:1-6. 2010
    ....
  46. ncbi In vivo recombination after chronic damage exposure falls to below spontaneous levels in "recombomice"
    Olga Kovalchuk
    Department of Biological Sciences, University of Lethbridge, Lethbridge, Alberta, Canada
    Mol Cancer Res 2:567-73. 2004
    ....
  47. ncbi Maternal stress induces epigenetic signatures of psychiatric and neurological diseases in the offspring
    Fabiola C R Zucchi
    Department of Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada
    PLoS ONE 8:e56967. 2013
    ..These observations provide a new mechanistic association between environmental and genetic risk factors in psychiatric and neurological disease...
  48. ncbi Pathogen-induced systemic plant signal triggers DNA rearrangements
    Igor Kovalchuk
    Department of Biological Sciences, University of Lethbridge, Lethbridge, Alberta T1K 3M4, Canada
    Nature 423:760-2. 2003
    ..These results indicate the existence of a systemic recombination signal that also results in an increased frequency of meiotic and/or inherited late somatic recombination...
  49. ncbi A new use for transgenic plants--environmental biomonitors
    Igor Kovalchuk
    Department of Biological Sciences, University of Lethbridge, Lethbridge, Alberta T1K 3M4, Canada
    Biotechnol Genet Eng Rev 20:23-45. 2003
  50. ncbi Loss of DNA methylation and histone H4 lysine 20 trimethylation in human breast cancer cells is associated with aberrant expression of DNA methyltransferase 1, Suv4-20h2 histone methyltransferase and methyl-binding proteins
    Volodymyr P Tryndyak
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AK 72079, USA
    Cancer Biol Ther 5:65-70. 2006
    ..Such epigenetic dysregulation may contribute to and may be indicative of the formation of a more aggressive tumor phenotype during tumor progression...
  51. ncbi Fractionated low-dose radiation exposure leads to accumulation of DNA damage and profound alterations in DNA and histone methylation in the murine thymus
    Igor Pogribny
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas, USA
    Mol Cancer Res 3:553-61. 2005
    ..Our results show the involvement of epigenetic alterations in radiation-induced responses in vivo. These changes may play a role in genome destabilization that ultimately leads to cancer...
  52. ncbi Effect of long-term tamoxifen exposure on genotoxic and epigenetic changes in rat liver: implications for tamoxifen-induced hepatocarcinogenesis
    Volodymyr P Tryndyak
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Carcinogenesis 27:1713-20. 2006
    ..These data indicate the importance of genotoxic and epigenetic alterations in the etiology of tamoxifen-induced hepatocarcinogenesis...
  53. ncbi Epigenetic reprogramming of liver cells in tamoxifen-induced rat hepatocarcinogenesis
    Volodymyr P Tryndyak
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Mol Carcinog 46:187-97. 2007
    ....
  54. ncbi Induction of microRNAome deregulation in rat liver by long-term tamoxifen exposure
    Igor P Pogribny
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, United States
    Mutat Res 619:30-7. 2007
    ..Thus, our findings indicate that miRNA changes occur prior to tumor formation and are not merely a consequence of a transformed state...
  55. ncbi Identification of differentially methylated sites within unmethylated DNA domains in normal and cancer cells
    Volodymyr Tryndyak
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Anal Biochem 356:202-7. 2006
    ....
  56. ncbi Epigenetic profiling of multidrug-resistant human MCF-7 breast adenocarcinoma cells reveals novel hyper- and hypomethylated targets
    Nataliya Yu Lukyanova
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Mol Cancer Ther 6:1089-98. 2007
    ..Finally, deregulation of similar pathways may explain the existence and provide mechanism of cross-resistance of cancer cells to different types of chemotherapeutic agents...
  57. ncbi DNA double-strand breaks form in bystander cells after microbeam irradiation of three-dimensional human tissue models
    Olga A Sedelnikova
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 67:4295-302. 2007
    ..Thus, this study points to the importance of considering the indirect biological effects of radiation in cancer risk assessment...
  58. ncbi Dose-dependence, sex- and tissue-specificity, and persistence of radiation-induced genomic DNA methylation changes
    Igor Pogribny
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Biochem Biophys Res Commun 320:1253-61. 2004
    ..Based on the correlation between the levels of DNA methylation and DNA damage we propose that radiation-induced global genome DNA hypomethylation is DNA repair-related...
  59. ncbi Gene expression profiling reveals underlying molecular mechanisms of the early stages of tamoxifen-induced rat hepatocarcinogenesis
    Igor P Pogribny
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Toxicol Appl Pharmacol 225:61-9. 2007
    ..The early appearance of these alterations suggests their importance in the mechanism of neoplastic cell transformation induced by tamoxifen...
  60. ncbi Tandem repeat mutation, global DNA methylation, and regulation of DNA methyltransferases in cultured mouse embryonic fibroblast cells chronically exposed to chemicals with different modes of action
    Carole L Yauk
    Environmental Health Sciences and Research Bureau, Safe Environments Programme, Health Canada, Ottawa, Ontario, Canada
    Environ Mol Mutagen 49:26-35. 2008
    ....
  61. ncbi Germ-line mutations, DNA damage, and global hypermethylation in mice exposed to particulate air pollution in an urban/industrial location
    Carole Yauk
    Environmental and Occupational Toxicology Division, HECSB, Ottawa, ON, Canada K1A 0K9
    Proc Natl Acad Sci U S A 105:605-10. 2008
    ..Changes in methylation can have widespread repercussions for chromatin structure, gene expression and genome stability. Potential health effects warrant extensive further investigation...
  62. ncbi Epigenetic research sheds new light on the nature of interactions between organisms and their environment
    Olga Kovalchuk
    Environ Mol Mutagen 49:1-3. 2008