Research Topics
| Michael J KovacsSummaryAffiliation: University of Western Ontario Country: Canada Publications
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Publications
Long-term low-dose warfarin use is effective in the prevention of recurrent venous thromboembolism: noM J Kovacs
Department of Hematology, London Health Sciences Center, London, Ontario, Canada
J Thromb Haemost 2:1041-3. 2004- A pilot study of central venous catheter survival in cancer patients using low-molecular-weight heparin (dalteparin) and warfarin without catheter removal for the treatment of upper extremity deep vein thrombosis (The Catheter Study)M J Kovacs
Department of Medicine, Victoria Hospital, London, ON, Canada
J Thromb Haemost 5:1650-3. 2007..Central venous catheters in patients with cancer are associated with development of deep vein thrombosis (DVT); however, there is no accepted standard treatment... 
Normal levels of protein C and protein S tested in the acute phase of a venous thromboembolic event are not falsely elevatedLeonard Minuk
Department of Medicine, Division of Hematology, London Health Sciences Centre, London, Ontario, Canada
Thromb J 8:10. 2010..In the current study, we sought to show that normal PC and PS values determined during the acute phase of VTE are not false negatives...
Effectiveness of compression stockings to prevent the post-thrombotic syndrome (the SOX Trial and Bio-SOX biomarker substudy): a randomized controlled trialSusan R Kahn
Centre for Clinical Epidemiology and Community Studies, Jewish General Hospital, Montreal, Quebec, Canada
BMC Cardiovasc Disord 7:21. 2007..Elastic compression stockings (ECS) could be helpful in preventing PTS; however, data on their effectiveness are scarce and conflicting...- Prospective assessment of the natural history of positive D-dimer results in persons with acute venous thromboembolism (DVT or PE)John Kuruvilla
Department of Hematology, University of British Columbia, Vancouver, British Columbia, Canada
Thromb Haemost 89:284-7. 2003..D-dimer testing for the diagnosis of recurrence of venous thromboembolism deserves further study... - Comparison of 10-mg and 5-mg warfarin initiation nomograms together with low-molecular-weight heparin for outpatient treatment of acute venous thromboembolism. A randomized, double-blind, controlled trialMichael J Kovacs
Department of Hematology, London Health Sciences Centre, 800 Commissioners Road East, London, Ontario N6A 4G5, Canada
Ann Intern Med 138:714-9. 2003..The optimal means of achieving therapeutic oral anticoagulation in the outpatient setting has not been determined... - Prospective assessment of a nomogram for the initiation of oral anticoagulation therapy for outpatient treatment of venous thromboembolismM J Kovacs
Department of Medicine, London Health Sciences Centre, London, Ontario, Canada
Pathophysiol Haemost Thromb 32:131-3. 2002..There were no major bleeds and only 6 instances of INR >4.5. This outpatient warfarin nomogram appears to be safe and efficacious in obtaining timely therapeutic levels of warfarin and deserves further study... - Anti-Xa effect of a low molecular weight heparin (dalteparin) does not accumulate in extended duration therapy for venous thromboembolism in cancer patientsMichael J Kovacs
London Health Sciences Centre, 800 Commissioners Road East, London, Ontario, N6A 4G5, Canada
Thromb Haemost 93:1185-8. 2005..Monitoring of anti-Xa levels in this situation is usually not required... - Influence of warfarin on symptoms of fatigue: findings of a randomized trialMichael J Kovacs
Department of Medicine, University of Western Ontario, London, Ontario, Canada
Ann Pharmacother 39:840-2. 2005..Some patients develop fatigue while taking warfarin, but causality is uncertain... - Successful treatment of heparin induced thrombocytopenia (HIT) with fondaparinuxMichael J Kovacs
London Health Sciences Centre, ON, Canada
Thromb Haemost 93:999-1000. 2005 - Protein C and protein S levels can be accurately determined within 24 hours of diagnosis of acute venous thromboembolismM J Kovacs
Department of Medicine, London Health Sciences Centre, London, ON, Canada
Clin Lab Haematol 28:9-13. 2006..8% of initial protein C and protein S results were accurate. If protein C and protein S are measured at the time of diagnosis of acute venous thromboembolism, the majority of the results will be normal and false positives are uncommon... - A comparison of three rapid D-dimer methods for the diagnosis of venous thromboembolismM J Kovacs
Department of Medicine, London Health Sciences Centre, London, Ontario, Canada
Br J Haematol 115:140-4. 2001..The SimpliRED D-dimer was found to be less sensitive than the Accuclot or IL-Test. When combined with pre-test probability all three methods are probably acceptable for use in the diagnosis of venous thromboembolism... 
Ambulatory management of pulmonary embolism: a pragmatic evaluationM J Kovacs
Division of Hematology, Department of Medicine, University of Western Ontario, London, ON, Canada
J Thromb Haemost 8:2406-11. 2010..Patients diagnosed with pulmonary embolism should be considered for treatment on an outpatient basis; however, this practise is not accepted in many centers...- Randomized assessment of a warfarin nomogram for initial oral anticoagulation after venous thromboembolic diseaseM J Kovacs
Department of Hematology, London Health Sciences Centre, London, Ont, Canada
Haemostasis 28:62-9. 1998..0 vs. 5.6 days, p = 0.02). The warfarin nomogram as tested is safe and leads to a significantly shorter length of stay for patients with primary venous thromboembolism as compared to standard practice... - Body weight does not predict for anti-Xa levels after fixed dose prophylaxis with enoxaparin after orthopedic surgeryM J Kovacs
Department of Medicine, University of Western Ontario, Canada
Thromb Res 91:137-42. 1998..Recognizing the low overall event rate this study does not support the need to monitor anti-Xa levels or adjusting the dose according to weight... - Outpatient treatment of pulmonary embolism with dalteparinM J Kovacs
London Health Sciences Centre, University of Western Ontario, Canada
Thromb Haemost 83:209-11. 2000.... - Single-arm study of bridging therapy with low-molecular-weight heparin for patients at risk of arterial embolism who require temporary interruption of warfarinM J Kovacs
London Health Sciences Centre, 800 Commissioners Rd E, London, Ontario, Canada N6A 4G5
Circulation 110:1658-63. 2004..However, this practice has never been evaluated in a large prospective study. This study was designed to assess the efficacy and safety of bridging therapy with low-molecular-weight heparin initiated out of hospital... - A phase II study of ZD6474 (Zactima, a selective inhibitor of VEGFR and EGFR tyrosine kinase in patients with relapsed multiple myeloma--NCIC CTG IND.145Michael J Kovacs
NCIC Clinical Trials Group, Kingston, Ontario, Canada
Invest New Drugs 24:529-35. 2006..However, this was not reflected in clinical benefit since none of the patients had a reduction in M protein... - The standard is still the standard or why an INR of 2-3 is still the optimal intensity for secondary prevention of venous thromboembolismMichael J Kovacs
London Health Sciences Centre, 800 Commissioners Road East, London, Ontario N6A 4G5, Canada
J Thromb Thrombolysis 21:53-6. 2006..For long term secondary prophylaxis of spontaneous venous thromboembolism, the optimal INR intensity of warfarin remains 2.0-3.0... - Patients with a first symptomatic unprovoked deep vein thrombosis are at higher risk of recurrent venous thromboembolism than patients with a first unprovoked pulmonary embolismM J Kovacs
Department of Hematology, London Health Sciences Centre, Victoria Hospital, London, Ontario, Canada
J Thromb Haemost 8:1926-32. 2010.... - Psychological impact of thrombophilia testing in asymptomatic family membersMartha L Louzada
University of Western Ontario, London, Ontario, Canada
Thromb Res 128:530-5. 2011.... - Development of a clinical prediction rule for risk stratification of recurrent venous thromboembolism in patients with cancer-associated venous thromboembolismMartha L Louzada
Department of Medicine, Division of Hematology, University of Western Ontario, 800 E3637 Commissioners Rd E, London, ON, Canada, N6A 5W9
Circulation 126:448-54. 2012..We performed a retrospective cohort study and a validation study in patients with cancer-associated VTE to derive a clinical prediction rule that stratifies VTE recurrence risk... - Low-molecular-weight heparin versus a coumarin for the prevention of recurrent venous thromboembolism in patients with cancerAgnes Y Y Lee
Department of Medicine, McMaster University, Hamilton, Ont, Canada
N Engl J Med 349:146-53. 2003..CONCLUSIONS: In patients with cancer and acute venous thromboembolism, dalteparin was more effective than an oral anticoagulant in reducing the risk of recurrent thromboembolism without increasing the risk of bleeding... - Risk of recurrent venous thromboembolism after a first oestrogen-associated episode. Data from the REVERSE cohort studyGregoire Le Gal
Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada
Thromb Haemost 104:498-503. 2010..The risk of recurrent VTE is low in women after a first otherwise unprovoked oestrogen-associated VTE. However, this risk is not significantly lower than in women whose VTE was not related to oestrogen use... - Evidence-based management of anticoagulant therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice GuidelinesAnne Holbrook
Division of Clinical Pharmacology and Therapeutics, Department of Medicine, McMaster University, Hamilton, ON, Canada
Chest 141:e152S-84S. 2012..This article focuses on the common important management questions for which, at a minimum, low-quality published evidence is available to guide best practices... - An evaluation of D-dimer in the diagnosis of pulmonary embolism: a randomized trialClive Kearon
McMaster University and the Henderson Research Centre, Hamilton, Ontario, Canada
Ann Intern Med 144:812-21. 2006..It may be safe to omit additional diagnostic testing in selected patients with suspected pulmonary embolism (PE) who have a negative D-dimer test, but this approach has never been evaluated in a randomized, controlled trial... - Evaluation of D-dimer in the diagnosis of suspected deep-vein thrombosisPhilip S Wells
Department of Medicine, Ottawa Hospital, University of Ottawa, Ottawa, Ont, Canada
N Engl J Med 349:1227-35. 2003.... - A comparison of two intensities of warfarin for the prevention of recurrent thrombosis in patients with the antiphospholipid antibody syndromeMark A Crowther
Department of Medicine, McMaster University, Hamilton, Ont, Canada
N Engl J Med 349:1133-8. 2003..0. However, there are no prospective data to support this approach to thromboprophylaxis... - Oral vitamin K versus placebo to correct excessive anticoagulation in patients receiving warfarin: a randomized trialMark A Crowther
McMaster University, Hamilton, Ontario, Canada
Ann Intern Med 150:293-300. 2009..Low-dose oral vitamin K decreases the international normalized ratio (INR) in overanticoagulated patients who receive warfarin therapy. Its effects on bleeding events are uncertain... - Study of Octaplex dosing accuracy: an in vitro analysisChristopher J Patriquin
Department of Medicine, University of Western Ontario, London, Ontario, Canada
Thromb Haemost 107:248-52. 2012..5 but factors were not uniformly >0.50 IU until 2,000 IU, and not >1.00 IU until 3,000 IU. This suggests that INR correction alone may not accurately reflect factor activity, and lends support for weight-based dosing... - A pilot study to assess the feasibility of a multicenter cluster randomized trial for the management of asymptomatic persons with a thrombophiliaPhilip S Wells
University of Ottawa, ON, Canada
J Genet Couns 18:475-82. 2009..The question of the best educational approach in these patients remains unanswered. The value of testing and following asymptomatic carriers of probands with VTE and thrombophilia remains unknown... - Computed tomographic pulmonary angiography vs ventilation-perfusion lung scanning in patients with suspected pulmonary embolism: a randomized controlled trialDavid R Anderson
Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
JAMA 298:2743-53. 2007..Ventilation-perfusion scanning has been largely replaced by CTPA in many centers despite limited comparative formal evaluations and concerns about CTPA's low sensitivity (ie, chance of missing clinically important pulmonary embuli)... - A 10 mg warfarin initiation nomogram is safe and effective in outpatients starting oral anticoagulant therapy for venous thromboembolismKatherine Monkman
Department of Medicine, Division of Hematology, University of Western Ontario, London, Ontario, Canada
Thromb Res 124:275-80. 2009..Eighty-four percent of patients achieved a therapeutic INR by day 5. In outpatients, a 10 mg nomogram results in timely achievement of a therapeutic INR with an acceptable incidence of bleeding and recurrent thromboembolism... - Six-month exercise training program to treat post-thrombotic syndrome: a randomized controlled two-centre trialSusan R Kahn
Department of Medicine, McGill University, Ottawa, Ont, Canada
CMAJ 183:37-44. 2011.... - Expanding eligibility for outpatient treatment of deep venous thrombosis and pulmonary embolism with low-molecular-weight heparin: a comparison of patient self-injection with homecare injectionP S Wells
Department of Medicine, University of Ottawa, Ontario, Canada
Arch Intern Med 158:1809-12. 1998.... - The safety of dosing dalteparin based on actual body weight for the treatment of acute venous thromboembolism in obese patientsE Al-Yaseen
London Health Sciences Center, London, Ontario, Canada
J Thromb Haemost 3:100-2. 2005..0-3.0. All patients were followed for 12 weeks post diagnosis. Only two patients had a major hemorrhage, 4 and 8 weeks from diagnosis. This study supports the safety of dosing dalteparin based on actual body weight in obese patients... - Comparison of 1 month with 3 months of anticoagulation for a first episode of venous thromboembolism associated with a transient risk factorC Kearon
McMaster University, Hamilton, Ontario, Canada
J Thromb Haemost 2:743-9. 2004..Retrospective analyses suggest that 1 month of anticoagulation is adequate for patients whose venous thromboembolic event was provoked by a transient risk factor... - Treatment of relapsed and refractory myelomaDonna E Reece
Program for Multiple Myeloma and Related Diseases, Princess Margaret Hospital, Toronto, Ontario, Canada
Leuk Lymphoma 49:1470-85. 2008.... - Identifying unprovoked thromboembolism patients at low risk for recurrence who can discontinue anticoagulant therapyMarc A Rodger
Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, Ont
CMAJ 179:417-26. 2008..We sought to determine clinical predictors to identify patients who are at low risk of recurrent venous thromboembolism who could safely discontinue oral anticoagulants... - Predicting warfarin doseAlejandro Lazo-Langner
Department of Medicine, Division of Hematology, University of Western Ontario, and London Health Sciences Centre, Victoria Hospital, London, Ontario, Canada
Curr Opin Pulm Med 16:426-31. 2010..It has been suggested that dosing algorithms incorporating genetics might outperform usual care but it is still unclear whether such an approach has a definitive clinical advantage... - Use of spiral computed tomography contrast angiography and ultrasonography to exclude the diagnosis of pulmonary embolism in the emergency departmentDavid R Anderson
Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
J Emerg Med 29:399-404. 2005..These findings suggest that the combination of a negative spiral CT contrast angiography scan and normal venous ultrasound imaging safely excludes the diagnosis of pulmonary embolism in the Emergency Department setting... - Combined use of clinical assessment and d-dimer to improve the management of patients presenting to the emergency department with suspected deep vein thrombosis (the EDITED Study)D R Anderson
Department of Medicine, QEII Health Sciences Center, Dalhousie University, Halifax, Nova Scotia, Canada
J Thromb Haemost 1:645-51. 2003..5%) developed pulmonary embolism in the follow-up period. A diagnostic strategy for the evaluation of patients with suspected DVT based on pretest probability and d-dimer is safe and feasible in the emergency department setting... - Extended outpatient therapy with low molecular weight heparin for the treatment of recurrent venous thromboembolism despite warfarin therapyC Luk
University of Western Ontario, London, Ontario, Canada
Am J Med 111:270-3. 2001.... - Dalteparin as periprocedure anticoagulation for patients on warfarin and at high risk of thrombosisA H Tinmouth
Canadian Blood Services, Toronto, Ontario, Canada
Ann Pharmacother 35:669-74. 2001..CONCLUSIONS: Outpatient perioperative anticoagulation with dalteparin for high-risk patients requiring long-term oral anticoagulation appears feasible and warrants further study... - The prevalence of antibodies to the platelet factor 4 -heparin complex and association with access thrombosis in patients on chronic hemodialysisMarc Carrier
Thrombosis Program, Division of Hematology, University of Ottawa, Ottawa, Ontario, Canada
Thromb Res 120:215-20. 2007.... - Effect of 3.2 vs. 3.8% sodium citrate concentration on anti-Xa levels for patients on therapeutic low molecular weight heparinS Payne
Unversity of Western Ontario, Ontario, Canada
Clin Lab Haematol 25:317-9. 2003..In accordance with previous recommendations, we advocate the exclusive use of 3.2% sodium citrate in an effort to standardize coagulation testing... - Low molecular weight heparin for the treatment of retinal vein occlusion: a systematic review and meta-analysis of randomized trialsAlejandro Lazo-Langner
Hematology Division, London Health Sciences Centre, Victoria Hospital 800 Commissioners Rd E PO Box 5010 Rm A2 401 London ON, N6A 5W9, Canada
Haematologica 95:1587-93. 2010..Further studies are required to confirm these findings and clarify its benefits in specific subgroups of patients before definitive recommendations can be made... - Results of a multicenter randomized phase II trial of thalidomide and prednisone maintenance therapy for multiple myeloma after autologous stem cell transplantA Keith Stewart
Princess Margaret Hospital, Toronto, Ontario, Canada
Clin Cancer Res 10:8170-6. 2004.... - Validation of a diagnostic approach to exclude recurrent venous thromboembolismG Le Gal
Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, ON, Canada
J Thromb Haemost 7:752-9. 2009..Our objective was to evaluate the safety of a diagnostic strategy utilizing comparison of diagnostic test results with baseline imaging results to rule out suspected recurrent VTE... - Serum lipoprotein (a) levels in patients with first unprovoked venous thromboembolism is not associated with subsequent risk of recurrent VTEM A Rodger
Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Clinical Epidemiology Unit, Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, Ottawa, Ontario, Canada
Thromb Res 126:222-6. 2010..We sought to determine if serum Lp(a) levels in patients with unprovoked VTE who discontinue anticoagulants after 5 to 7 months of therapy predict VTE recurrence in a prospective cohort study... - Excluding pulmonary embolism at the bedside without diagnostic imaging: management of patients with suspected pulmonary embolism presenting to the emergency department by using a simple clinical model and d-dimerP S Wells
Division of Hematology, The Ottawa Hospital, Civic Campus, Suite 452, 737 Parkdale Avenue, Ottawa, Ontario K1Y 1J8, Canada
Ann Intern Med 135:98-107. 2001..5% (CI, 99.1% to 100%). CONCLUSION: Managing patients for suspected pulmonary embolism on the basis of pretest probability and D -dimer result is safe and decreases the need for diagnostic imaging... - Should vitamin K antagonist therapy be started simultaneously with parenteral anticoagulation: a meta-analysis?Fareeha Qayyum
aDepartment of Clinical Epidemiology and Biostatistics bDivision of Clinical Pharmacology and Therapeutics cDepartment of Medicine, McMaster University dCentre for Evaluation of Medicines, St Joseph s Healthcare Hamilton, Hamilton, Ontario eDivision of Hematology, Department of Medicine, University of Western Ontario, London, Ontario, Canada
Blood Coagul Fibrinolysis 23:705-13. 2012..However, these results should be interpreted with caution, as the quality and quantity of evidence is limited... - Predicting warfarin maintenance dose in patients with venous thromboembolism based on the response to a standardized warfarin initiation nomogramA Lazo-Langner
Division of Hematology, Department of Medicine, University of Western Ontario, London, ON, Canada
J Thromb Haemost 7:1276-83. 2009..Standardized warfarin initiation nomograms are safe and effective and patients' responses to them could be used to predict warfarin requirements without the need for genetic testing... - A latex D-dimer reliably excludes venous thromboembolismS M Bates
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Arch Intern Med 161:447-53. 2001..D-Dimer, a cross-linked fibrin degradation product, has a high sensitivity in patients with suspected venous thrombosis. Traditional latex D-dimer assays, however, have not been sufficiently sensitive to exclude venous thromboembolism... - Fondaparinux: a potential new therapy for HITK H M Kuo
University of Western Ontario, London, Ontario, Canada
Hematology 10:271-5. 2005..Successes in the use of fondaparinux in the treatment of HIT, as demonstrated in recent published case reports, warrant further study in larger controlled trials for this indication... - Cutaneous dalteparin reactions associated with antibodies of heparin-induced thrombocytopeniaSonja M Payne
University of Western Ontario, London, Ontario, Canada
Ann Pharmacother 37:655-8. 2003..Patients who develop skin lesions should have their heparin therapy discontinued and a diagnosis of HIT investigated... - Imatinib mesylate treatment in two patients with idiopathic hypereosinophilic syndromeSonja M Payne
University of Western Ontario, London, Ontario, Canada
Ann Pharmacother 38:1215-8. 2004.... - Heparin-induced thrombocytopeniaA K Gupta
Department of Medicine, University of Toronto, Sunnybrook Health Science Center, North York, Ontario, Canada
Ann Pharmacother 32:55-9. 1998..To highlight the importance of heparin-induced thrombocytopenia (HIT), a potentially fatal adverse effect of heparin therapy... - Does the type of hormone replacement therapy influence the risk of deep vein thrombosis? A prospective case-control studyJ D Douketis
Department of Medicine, McMaster University, Hamilton, Canada
J Thromb Haemost 3:943-8. 2005..Although hormone replacement therapy (HRT) is associated with an increased risk of deep vein thrombosis (DVT), it is not clear if the risk differs in users of combined estrogen-progestin HRT and estrogen-only HRT... - Increased mortality in hemodialysis patients having specific antibodies to the platelet factor 4-heparin complexM Carrier
Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada
Kidney Int 73:213-9. 2008..Our study suggests that IgG-specific PF4-H antibody formation is associated with increased mortality in hemodialysis patients... - Frequently relapsing thrombotic thrombocytopenic purpura treated with cytotoxic immunosuppressive therapyD S Allan
Divison of Hematology, Department of Medicine, University of Western Ontario, London, Ontario, Canada
Haematologica 86:844-50. 2001..Immunosuppression, thus, has a biologically plausible role in TTP. We describe three consecutive cases of relapsing TTP treated with cytotoxic therapy to highlight the potential role of immunosuppression... - Long-term dalteparin in pregnancy not associated with a decrease in bone mineral density: substudy of a randomized controlled trialM A Rodger
Ottawa Health Research Institute, University of Ottawa, Ottawa, ON, Canada
J Thromb Haemost 5:1600-6. 2007..The risk of decreased bone mineral density (BMD) with prophylactic dose long-term low-molecular-weight heparin (LMWH) is unknown... - Standard-intensity vs low-dose anticoagulation for long-term management of patients with venous thromboembolismAlejandro Lazo-Langner
The Ottawa Hospital, Department of Epidemiology and Community Medicine, University of Ottawa
Clin Adv Hematol Oncol 3:877-9. 2005 - Comparison of low-intensity warfarin therapy with conventional-intensity warfarin therapy for long-term prevention of recurrent venous thromboembolismClive Kearon
McMaster University, Hamilton, Ont
N Engl J Med 349:631-9. 2003..The low-intensity warfarin regimen does not reduce the risk of clinically important bleeding... - Comparing the quality of oral anticoagulant management by anticoagulation clinics and by family physicians: a randomized controlled trialS Jo Anne Wilson
Department of Pharmacy, Queen Elizabeth II Health Sciences Centre and Dalhousie University, Halifax, NS
CMAJ 169:293-8. 2003..We carried out a randomized controlled trial to evaluate these 2 models of anticoagulant care... - A randomized trial comparing 2 low-molecular-weight heparins for the outpatient treatment of deep vein thrombosis and pulmonary embolismPhilip S Wells
Departments of Medicine, University of Ottawa, Ottawa Health Research Institute, Ottawa, Ontario
Arch Intern Med 165:733-8. 2005..No published trials have compared LMWHs, and few studies have examined outpatient therapy for PE. Only tinzaparin sodium has demonstrated superiority to unfractionated heparin in a clinical trial... - The effect of dalteparin on coagulation activation during pregnancy in women with thrombophilia. A randomized trialKarim Abou Nassar
The Ottawa Hospital, General Campus, 501 Smyth Road, Box 201, Ottawa, ONT K1H 8L6, Canada
Thromb Haemost 98:163-71. 2007..Prophylaxis with dalteparin at doses used in this study did not reduce coagulation activation in high risk thrombophilic women during pregnancy... - A randomised comparison of melphalan with prednisone or dexamethasone as induction therapy and dexamethasone or observation as maintenance therapy in multiple myeloma: NCIC CTG MY.7Chaim Shustik
Royal Victoria Hospital, Montreal, QC, Canada
Br J Haematol 136:203-11. 2007..Dexamethasone did not improve clinical outcome when combined with melphalan during induction; maintenance dexamethasone improved PFS, but this did not translate into a detectable survival advantage... - Deep vein thrombosisClive Kearon
Lancet 366:118; author reply 119-20. 2005 - Inter-observer reliability of measures to assess the post-thrombotic syndromeMarc A Rodger
Thromb Haemost 100:164-6. 2008 - Timing of hypercoagulable screensMichael J Kovacs
Arch Intern Med 162:613-4. 2002