Michael J Kovacs

Summary

Affiliation: University of Western Ontario
Country: Canada

Publications

  1. ncbi request reprint A pilot study of central venous catheter survival in cancer patients using low-molecular-weight heparin (dalteparin) and warfarin without catheter removal for the treatment of upper extremity deep vein thrombosis (The Catheter Study)
    M J Kovacs
    Department of Medicine, Victoria Hospital, London, ON, Canada
    J Thromb Haemost 5:1650-3. 2007
  2. ncbi request reprint Long-term low-dose warfarin use is effective in the prevention of recurrent venous thromboembolism: no
    M J Kovacs
    Department of Hematology, London Health Sciences Center, London, Ontario, Canada
    J Thromb Haemost 2:1041-3. 2004
  3. ncbi request reprint Prospective assessment of the natural history of positive D-dimer results in persons with acute venous thromboembolism (DVT or PE)
    John Kuruvilla
    Department of Hematology, University of British Columbia, Vancouver, British Columbia, Canada
    Thromb Haemost 89:284-7. 2003
  4. ncbi request reprint Comparison of 10-mg and 5-mg warfarin initiation nomograms together with low-molecular-weight heparin for outpatient treatment of acute venous thromboembolism. A randomized, double-blind, controlled trial
    Michael J Kovacs
    Department of Hematology, London Health Sciences Centre, 800 Commissioners Road East, London, Ontario N6A 4G5, Canada
    Ann Intern Med 138:714-9. 2003
  5. pmc Normal levels of protein C and protein S tested in the acute phase of a venous thromboembolic event are not falsely elevated
    Leonard Minuk
    Department of Medicine, Division of Hematology, London Health Sciences Centre, London, Ontario, Canada
    Thromb J 8:10. 2010
  6. pmc Effectiveness of compression stockings to prevent the post-thrombotic syndrome (the SOX Trial and Bio-SOX biomarker substudy): a randomized controlled trial
    Susan R Kahn
    Centre for Clinical Epidemiology and Community Studies, Jewish General Hospital, Montreal, Quebec, Canada
    BMC Cardiovasc Disord 7:21. 2007
  7. ncbi request reprint Prospective assessment of a nomogram for the initiation of oral anticoagulation therapy for outpatient treatment of venous thromboembolism
    M J Kovacs
    Department of Medicine, London Health Sciences Centre, London, Ontario, Canada
    Pathophysiol Haemost Thromb 32:131-3. 2002
  8. ncbi request reprint Successful treatment of heparin induced thrombocytopenia (HIT) with fondaparinux
    Michael J Kovacs
    London Health Sciences Centre, ON, Canada
    Thromb Haemost 93:999-1000. 2005
  9. ncbi request reprint A phase II study of ZD6474 (Zactima, a selective inhibitor of VEGFR and EGFR tyrosine kinase in patients with relapsed multiple myeloma--NCIC CTG IND.145
    Michael J Kovacs
    NCIC Clinical Trials Group, Kingston, Ontario, Canada
    Invest New Drugs 24:529-35. 2006
  10. doi request reprint Ambulatory management of pulmonary embolism: a pragmatic evaluation
    M J Kovacs
    Division of Hematology, Department of Medicine, University of Western Ontario, London, ON, Canada
    J Thromb Haemost 8:2406-11. 2010

Collaborators

Detail Information

Publications72

  1. ncbi request reprint A pilot study of central venous catheter survival in cancer patients using low-molecular-weight heparin (dalteparin) and warfarin without catheter removal for the treatment of upper extremity deep vein thrombosis (The Catheter Study)
    M J Kovacs
    Department of Medicine, Victoria Hospital, London, ON, Canada
    J Thromb Haemost 5:1650-3. 2007
    ..Central venous catheters in patients with cancer are associated with development of deep vein thrombosis (DVT); however, there is no accepted standard treatment...
  2. ncbi request reprint Long-term low-dose warfarin use is effective in the prevention of recurrent venous thromboembolism: no
    M J Kovacs
    Department of Hematology, London Health Sciences Center, London, Ontario, Canada
    J Thromb Haemost 2:1041-3. 2004
  3. ncbi request reprint Prospective assessment of the natural history of positive D-dimer results in persons with acute venous thromboembolism (DVT or PE)
    John Kuruvilla
    Department of Hematology, University of British Columbia, Vancouver, British Columbia, Canada
    Thromb Haemost 89:284-7. 2003
    ..D-dimer testing for the diagnosis of recurrence of venous thromboembolism deserves further study...
  4. ncbi request reprint Comparison of 10-mg and 5-mg warfarin initiation nomograms together with low-molecular-weight heparin for outpatient treatment of acute venous thromboembolism. A randomized, double-blind, controlled trial
    Michael J Kovacs
    Department of Hematology, London Health Sciences Centre, 800 Commissioners Road East, London, Ontario N6A 4G5, Canada
    Ann Intern Med 138:714-9. 2003
    ..The optimal means of achieving therapeutic oral anticoagulation in the outpatient setting has not been determined...
  5. pmc Normal levels of protein C and protein S tested in the acute phase of a venous thromboembolic event are not falsely elevated
    Leonard Minuk
    Department of Medicine, Division of Hematology, London Health Sciences Centre, London, Ontario, Canada
    Thromb J 8:10. 2010
    ..In the current study, we sought to show that normal PC and PS values determined during the acute phase of VTE are not false negatives...
  6. pmc Effectiveness of compression stockings to prevent the post-thrombotic syndrome (the SOX Trial and Bio-SOX biomarker substudy): a randomized controlled trial
    Susan R Kahn
    Centre for Clinical Epidemiology and Community Studies, Jewish General Hospital, Montreal, Quebec, Canada
    BMC Cardiovasc Disord 7:21. 2007
    ..Elastic compression stockings (ECS) could be helpful in preventing PTS; however, data on their effectiveness are scarce and conflicting...
  7. ncbi request reprint Prospective assessment of a nomogram for the initiation of oral anticoagulation therapy for outpatient treatment of venous thromboembolism
    M J Kovacs
    Department of Medicine, London Health Sciences Centre, London, Ontario, Canada
    Pathophysiol Haemost Thromb 32:131-3. 2002
    ..There were no major bleeds and only 6 instances of INR >4.5. This outpatient warfarin nomogram appears to be safe and efficacious in obtaining timely therapeutic levels of warfarin and deserves further study...
  8. ncbi request reprint Successful treatment of heparin induced thrombocytopenia (HIT) with fondaparinux
    Michael J Kovacs
    London Health Sciences Centre, ON, Canada
    Thromb Haemost 93:999-1000. 2005
  9. ncbi request reprint A phase II study of ZD6474 (Zactima, a selective inhibitor of VEGFR and EGFR tyrosine kinase in patients with relapsed multiple myeloma--NCIC CTG IND.145
    Michael J Kovacs
    NCIC Clinical Trials Group, Kingston, Ontario, Canada
    Invest New Drugs 24:529-35. 2006
    ..However, this was not reflected in clinical benefit since none of the patients had a reduction in M protein...
  10. doi request reprint Ambulatory management of pulmonary embolism: a pragmatic evaluation
    M J Kovacs
    Division of Hematology, Department of Medicine, University of Western Ontario, London, ON, Canada
    J Thromb Haemost 8:2406-11. 2010
    ..Patients diagnosed with pulmonary embolism should be considered for treatment on an outpatient basis; however, this practise is not accepted in many centers...
  11. ncbi request reprint The standard is still the standard or why an INR of 2-3 is still the optimal intensity for secondary prevention of venous thromboembolism
    Michael J Kovacs
    London Health Sciences Centre, 800 Commissioners Road East, London, Ontario N6A 4G5, Canada
    J Thromb Thrombolysis 21:53-6. 2006
    ..For long term secondary prophylaxis of spontaneous venous thromboembolism, the optimal INR intensity of warfarin remains 2.0-3.0...
  12. ncbi request reprint Protein C and protein S levels can be accurately determined within 24 hours of diagnosis of acute venous thromboembolism
    M J Kovacs
    Department of Medicine, London Health Sciences Centre, London, ON, Canada
    Clin Lab Haematol 28:9-13. 2006
    ..8% of initial protein C and protein S results were accurate. If protein C and protein S are measured at the time of diagnosis of acute venous thromboembolism, the majority of the results will be normal and false positives are uncommon...
  13. ncbi request reprint Single-arm study of bridging therapy with low-molecular-weight heparin for patients at risk of arterial embolism who require temporary interruption of warfarin
    M J Kovacs
    London Health Sciences Centre, 800 Commissioners Rd E, London, Ontario, Canada N6A 4G5
    Circulation 110:1658-63. 2004
    ..However, this practice has never been evaluated in a large prospective study. This study was designed to assess the efficacy and safety of bridging therapy with low-molecular-weight heparin initiated out of hospital...
  14. ncbi request reprint Anti-Xa effect of a low molecular weight heparin (dalteparin) does not accumulate in extended duration therapy for venous thromboembolism in cancer patients
    Michael J Kovacs
    London Health Sciences Centre, 800 Commissioners Road East, London, Ontario, N6A 4G5, Canada
    Thromb Haemost 93:1185-8. 2005
    ..Monitoring of anti-Xa levels in this situation is usually not required...
  15. ncbi request reprint Influence of warfarin on symptoms of fatigue: findings of a randomized trial
    Michael J Kovacs
    Department of Medicine, University of Western Ontario, London, Ontario, Canada
    Ann Pharmacother 39:840-2. 2005
    ..Some patients develop fatigue while taking warfarin, but causality is uncertain...
  16. doi request reprint Patients with a first symptomatic unprovoked deep vein thrombosis are at higher risk of recurrent venous thromboembolism than patients with a first unprovoked pulmonary embolism
    M J Kovacs
    Department of Hematology, London Health Sciences Centre, Victoria Hospital, London, Ontario, Canada
    J Thromb Haemost 8:1926-32. 2010
    ....
  17. ncbi request reprint Body weight does not predict for anti-Xa levels after fixed dose prophylaxis with enoxaparin after orthopedic surgery
    M J Kovacs
    Department of Medicine, University of Western Ontario, Canada
    Thromb Res 91:137-42. 1998
    ..Recognizing the low overall event rate this study does not support the need to monitor anti-Xa levels or adjusting the dose according to weight...
  18. ncbi request reprint A comparison of three rapid D-dimer methods for the diagnosis of venous thromboembolism
    M J Kovacs
    Department of Medicine, London Health Sciences Centre, London, Ontario, Canada
    Br J Haematol 115:140-4. 2001
    ..The SimpliRED D-dimer was found to be less sensitive than the Accuclot or IL-Test. When combined with pre-test probability all three methods are probably acceptable for use in the diagnosis of venous thromboembolism...
  19. ncbi request reprint Randomized assessment of a warfarin nomogram for initial oral anticoagulation after venous thromboembolic disease
    M J Kovacs
    Department of Hematology, London Health Sciences Centre, London, Ont, Canada
    Haemostasis 28:62-9. 1998
    ..0 vs. 5.6 days, p = 0.02). The warfarin nomogram as tested is safe and leads to a significantly shorter length of stay for patients with primary venous thromboembolism as compared to standard practice...
  20. ncbi request reprint Outpatient treatment of pulmonary embolism with dalteparin
    M J Kovacs
    London Health Sciences Centre, University of Western Ontario, Canada
    Thromb Haemost 83:209-11. 2000
    ....
  21. doi request reprint Psychological impact of thrombophilia testing in asymptomatic family members
    Martha L Louzada
    University of Western Ontario, London, Ontario, Canada
    Thromb Res 128:530-5. 2011
    ....
  22. doi request reprint Development of a clinical prediction rule for risk stratification of recurrent venous thromboembolism in patients with cancer-associated venous thromboembolism
    Martha L Louzada
    Department of Medicine, Division of Hematology, University of Western Ontario, 800 E3637 Commissioners Rd E, London, ON, Canada, N6A 5W9
    Circulation 126:448-54. 2012
    ..We performed a retrospective cohort study and a validation study in patients with cancer-associated VTE to derive a clinical prediction rule that stratifies VTE recurrence risk...
  23. doi request reprint Risk of recurrent venous thromboembolism after a first oestrogen-associated episode. Data from the REVERSE cohort study
    Gregoire Le Gal
    Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Thromb Haemost 104:498-503. 2010
    ..The risk of recurrent VTE is low in women after a first otherwise unprovoked oestrogen-associated VTE. However, this risk is not significantly lower than in women whose VTE was not related to oestrogen use...
  24. ncbi request reprint Low-molecular-weight heparin versus a coumarin for the prevention of recurrent venous thromboembolism in patients with cancer
    Agnes Y Y Lee
    Department of Medicine, McMaster University, Hamilton, Ont, Canada
    N Engl J Med 349:146-53. 2003
    ..We compared the efficacy of a low-molecular-weight heparin with that of an oral anticoagulant agent in preventing recurrent thrombosis in patients with cancer...
  25. pmc Evidence-based management of anticoagulant therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
    Anne Holbrook
    Division of Clinical Pharmacology and Therapeutics, Department of Medicine, McMaster University, Hamilton, ON, Canada
    Chest 141:e152S-84S. 2012
    ..This article focuses on the common important management questions for which, at a minimum, low-quality published evidence is available to guide best practices...
  26. ncbi request reprint Evaluation of D-dimer in the diagnosis of suspected deep-vein thrombosis
    Philip S Wells
    Department of Medicine, Ottawa Hospital, University of Ottawa, Ottawa, Ont, Canada
    N Engl J Med 349:1227-35. 2003
    ....
  27. ncbi request reprint An evaluation of D-dimer in the diagnosis of pulmonary embolism: a randomized trial
    Clive Kearon
    McMaster University and the Henderson Research Centre, Hamilton, Ontario, Canada
    Ann Intern Med 144:812-21. 2006
    ..It may be safe to omit additional diagnostic testing in selected patients with suspected pulmonary embolism (PE) who have a negative D-dimer test, but this approach has never been evaluated in a randomized, controlled trial...
  28. doi request reprint Non-OO blood type influences the risk of recurrent venous thromboembolism. A cohort study
    Esteban Gandara
    Dr Marc Rodger, Division of Hematology, The Ottawa Hospital, General Campus, 501 Smyth Rd, Ottawa, ON K1H 8L6, Canada, Fax 1 613 739 6102, E mail
    Thromb Haemost 110:1172-9. 2013
    ..2-3.8). In conclusion, non-OO blood type is associated with a statistically significant and clinically relevant increased risk of recurrent VTE following discontinuation of anticoagulant therapy for a first episode of unprovoked VTE. ..
  29. doi request reprint Should vitamin K antagonist therapy be started simultaneously with parenteral anticoagulation: a meta-analysis?
    Fareeha Qayyum
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    Blood Coagul Fibrinolysis 23:705-13. 2012
    ..However, these results should be interpreted with caution, as the quality and quantity of evidence is limited...
  30. ncbi request reprint A comparison of two intensities of warfarin for the prevention of recurrent thrombosis in patients with the antiphospholipid antibody syndrome
    Mark A Crowther
    Department of Medicine, McMaster University, Hamilton, Ont, Canada
    N Engl J Med 349:1133-8. 2003
    ..0. However, there are no prospective data to support this approach to thromboprophylaxis...
  31. ncbi request reprint Oral vitamin K versus placebo to correct excessive anticoagulation in patients receiving warfarin: a randomized trial
    Mark A Crowther
    McMaster University, Hamilton, Ontario, Canada
    Ann Intern Med 150:293-300. 2009
    ..Low-dose oral vitamin K decreases the international normalized ratio (INR) in overanticoagulated patients who receive warfarin therapy. Its effects on bleeding events are uncertain...
  32. doi request reprint Study of Octaplex dosing accuracy: an in vitro analysis
    Christopher J Patriquin
    Department of Medicine, University of Western Ontario, London, Ontario, Canada
    Thromb Haemost 107:248-52. 2012
    ..5 but factors were not uniformly >0.50 IU until 2,000 IU, and not >1.00 IU until 3,000 IU. This suggests that INR correction alone may not accurately reflect factor activity, and lends support for weight-based dosing...
  33. doi request reprint A pilot study to assess the feasibility of a multicenter cluster randomized trial for the management of asymptomatic persons with a thrombophilia
    Philip S Wells
    University of Ottawa, ON, Canada
    J Genet Couns 18:475-82. 2009
    ..The question of the best educational approach in these patients remains unanswered. The value of testing and following asymptomatic carriers of probands with VTE and thrombophilia remains unknown...
  34. doi request reprint A 10 mg warfarin initiation nomogram is safe and effective in outpatients starting oral anticoagulant therapy for venous thromboembolism
    Katherine Monkman
    Department of Medicine, Division of Hematology, University of Western Ontario, London, Ontario, Canada
    Thromb Res 124:275-80. 2009
    ..Eighty-four percent of patients achieved a therapeutic INR by day 5. In outpatients, a 10 mg nomogram results in timely achievement of a therapeutic INR with an acceptable incidence of bleeding and recurrent thromboembolism...
  35. doi request reprint Computed tomographic pulmonary angiography vs ventilation-perfusion lung scanning in patients with suspected pulmonary embolism: a randomized controlled trial
    David R Anderson
    Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    JAMA 298:2743-53. 2007
    ..Ventilation-perfusion scanning has been largely replaced by CTPA in many centers despite limited comparative formal evaluations and concerns about CTPA's low sensitivity (ie, chance of missing clinically important pulmonary embuli)...
  36. pmc Six-month exercise training program to treat post-thrombotic syndrome: a randomized controlled two-centre trial
    Susan R Kahn
    Department of Medicine, McGill University, Ottawa, Ont, Canada
    CMAJ 183:37-44. 2011
    ....
  37. ncbi request reprint The safety of dosing dalteparin based on actual body weight for the treatment of acute venous thromboembolism in obese patients
    E Al-Yaseen
    London Health Sciences Center, London, Ontario, Canada
    J Thromb Haemost 3:100-2. 2005
    ..0-3.0. All patients were followed for 12 weeks post diagnosis. Only two patients had a major hemorrhage, 4 and 8 weeks from diagnosis. This study supports the safety of dosing dalteparin based on actual body weight in obese patients...
  38. ncbi request reprint Comparison of 1 month with 3 months of anticoagulation for a first episode of venous thromboembolism associated with a transient risk factor
    C Kearon
    McMaster University, Hamilton, Ontario, Canada
    J Thromb Haemost 2:743-9. 2004
    ..Retrospective analyses suggest that 1 month of anticoagulation is adequate for patients whose venous thromboembolic event was provoked by a transient risk factor...
  39. ncbi request reprint Expanding eligibility for outpatient treatment of deep venous thrombosis and pulmonary embolism with low-molecular-weight heparin: a comparison of patient self-injection with homecare injection
    P S Wells
    Department of Medicine, University of Ottawa, Ontario, Canada
    Arch Intern Med 158:1809-12. 1998
    ....
  40. doi request reprint Treatment of relapsed and refractory myeloma
    Donna E Reece
    Program for Multiple Myeloma and Related Diseases, Princess Margaret Hospital, Toronto, Ontario, Canada
    Leuk Lymphoma 49:1470-85. 2008
    ....
  41. pmc Identifying unprovoked thromboembolism patients at low risk for recurrence who can discontinue anticoagulant therapy
    Marc A Rodger
    Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, Ont
    CMAJ 179:417-26. 2008
    ..We sought to determine clinical predictors to identify patients who are at low risk of recurrent venous thromboembolism who could safely discontinue oral anticoagulants...
  42. doi request reprint Predicting warfarin dose
    Alejandro Lazo-Langner
    Department of Medicine, Division of Hematology, University of Western Ontario, and London Health Sciences Centre, Victoria Hospital, London, Ontario, Canada
    Curr Opin Pulm Med 16:426-31. 2010
    ..It has been suggested that dosing algorithms incorporating genetics might outperform usual care but it is still unclear whether such an approach has a definitive clinical advantage...
  43. ncbi request reprint Extended outpatient therapy with low molecular weight heparin for the treatment of recurrent venous thromboembolism despite warfarin therapy
    C Luk
    University of Western Ontario, London, Ontario, Canada
    Am J Med 111:270-3. 2001
    ....
  44. ncbi request reprint Dalteparin as periprocedure anticoagulation for patients on warfarin and at high risk of thrombosis
    A H Tinmouth
    Canadian Blood Services, Toronto, Ontario, Canada
    Ann Pharmacother 35:669-74. 2001
    ..CONCLUSIONS: Outpatient perioperative anticoagulation with dalteparin for high-risk patients requiring long-term oral anticoagulation appears feasible and warrants further study...
  45. ncbi request reprint Combined use of clinical assessment and d-dimer to improve the management of patients presenting to the emergency department with suspected deep vein thrombosis (the EDITED Study)
    D R Anderson
    Department of Medicine, QEII Health Sciences Center, Dalhousie University, Halifax, Nova Scotia, Canada
    J Thromb Haemost 1:645-51. 2003
    ..5%) developed pulmonary embolism in the follow-up period. A diagnostic strategy for the evaluation of patients with suspected DVT based on pretest probability and d-dimer is safe and feasible in the emergency department setting...
  46. ncbi request reprint Use of spiral computed tomography contrast angiography and ultrasonography to exclude the diagnosis of pulmonary embolism in the emergency department
    David R Anderson
    Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    J Emerg Med 29:399-404. 2005
    ..These findings suggest that the combination of a negative spiral CT contrast angiography scan and normal venous ultrasound imaging safely excludes the diagnosis of pulmonary embolism in the Emergency Department setting...
  47. ncbi request reprint The prevalence of antibodies to the platelet factor 4 -heparin complex and association with access thrombosis in patients on chronic hemodialysis
    Marc Carrier
    Thrombosis Program, Division of Hematology, University of Ottawa, Ottawa, Ontario, Canada
    Thromb Res 120:215-20. 2007
    ....
  48. ncbi request reprint Effect of 3.2 vs. 3.8% sodium citrate concentration on anti-Xa levels for patients on therapeutic low molecular weight heparin
    S Payne
    Unversity of Western Ontario, Ontario, Canada
    Clin Lab Haematol 25:317-9. 2003
    ..In accordance with previous recommendations, we advocate the exclusive use of 3.2% sodium citrate in an effort to standardize coagulation testing...
  49. pmc Low molecular weight heparin for the treatment of retinal vein occlusion: a systematic review and meta-analysis of randomized trials
    Alejandro Lazo-Langner
    Hematology Division, London Health Sciences Centre, Victoria Hospital 800 Commissioners Rd E PO Box 5010 Rm A2 401 London ON, N6A 5W9, Canada
    Haematologica 95:1587-93. 2010
    ..Further studies are required to confirm these findings and clarify its benefits in specific subgroups of patients before definitive recommendations can be made...
  50. ncbi request reprint Results of a multicenter randomized phase II trial of thalidomide and prednisone maintenance therapy for multiple myeloma after autologous stem cell transplant
    A Keith Stewart
    Princess Margaret Hospital, Toronto, Ontario, Canada
    Clin Cancer Res 10:8170-6. 2004
    ....
  51. doi request reprint Validation of a diagnostic approach to exclude recurrent venous thromboembolism
    G Le Gal
    Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, ON, Canada
    J Thromb Haemost 7:752-9. 2009
    ..Our objective was to evaluate the safety of a diagnostic strategy utilizing comparison of diagnostic test results with baseline imaging results to rule out suspected recurrent VTE...
  52. doi request reprint Serum lipoprotein (a) levels in patients with first unprovoked venous thromboembolism is not associated with subsequent risk of recurrent VTE
    M A Rodger
    Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Clinical Epidemiology Unit, Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, Ottawa, Ontario, Canada
    Thromb Res 126:222-6. 2010
    ..We sought to determine if serum Lp(a) levels in patients with unprovoked VTE who discontinue anticoagulants after 5 to 7 months of therapy predict VTE recurrence in a prospective cohort study...
  53. ncbi request reprint Excluding pulmonary embolism at the bedside without diagnostic imaging: management of patients with suspected pulmonary embolism presenting to the emergency department by using a simple clinical model and d-dimer
    P S Wells
    Division of Hematology, The Ottawa Hospital, Civic Campus, Suite 452, 737 Parkdale Avenue, Ottawa, Ontario K1Y 1J8, Canada
    Ann Intern Med 135:98-107. 2001
    ..5% (CI, 99.1% to 100%). CONCLUSION: Managing patients for suspected pulmonary embolism on the basis of pretest probability and D -dimer result is safe and decreases the need for diagnostic imaging...
  54. ncbi request reprint Fondaparinux: a potential new therapy for HIT
    K H M Kuo
    University of Western Ontario, London, Ontario, Canada
    Hematology 10:271-5. 2005
    ..Successes in the use of fondaparinux in the treatment of HIT, as demonstrated in recent published case reports, warrant further study in larger controlled trials for this indication...
  55. doi request reprint Predicting warfarin maintenance dose in patients with venous thromboembolism based on the response to a standardized warfarin initiation nomogram
    A Lazo-Langner
    Division of Hematology, Department of Medicine, University of Western Ontario, London, ON, Canada
    J Thromb Haemost 7:1276-83. 2009
    ..Standardized warfarin initiation nomograms are safe and effective and patients' responses to them could be used to predict warfarin requirements without the need for genetic testing...
  56. ncbi request reprint A latex D-dimer reliably excludes venous thromboembolism
    S M Bates
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Arch Intern Med 161:447-53. 2001
    ..D-Dimer, a cross-linked fibrin degradation product, has a high sensitivity in patients with suspected venous thrombosis. Traditional latex D-dimer assays, however, have not been sufficiently sensitive to exclude venous thromboembolism...
  57. ncbi request reprint Imatinib mesylate treatment in two patients with idiopathic hypereosinophilic syndrome
    Sonja M Payne
    University of Western Ontario, London, Ontario, Canada
    Ann Pharmacother 38:1215-8. 2004
    ..The other patient failed to respond to imatinib mesylate even at the maximum dose (up to 400 mg/day)...
  58. ncbi request reprint Cutaneous dalteparin reactions associated with antibodies of heparin-induced thrombocytopenia
    Sonja M Payne
    University of Western Ontario, London, Ontario, Canada
    Ann Pharmacother 37:655-8. 2003
    ....
  59. ncbi request reprint Heparin-induced thrombocytopenia
    A K Gupta
    Department of Medicine, University of Toronto, Sunnybrook Health Science Center, North York, Ontario, Canada
    Ann Pharmacother 32:55-9. 1998
    ..To highlight the importance of heparin-induced thrombocytopenia (HIT), a potentially fatal adverse effect of heparin therapy...
  60. ncbi request reprint Does the type of hormone replacement therapy influence the risk of deep vein thrombosis? A prospective case-control study
    J D Douketis
    Department of Medicine, McMaster University, Hamilton, Canada
    J Thromb Haemost 3:943-8. 2005
    ..Although hormone replacement therapy (HRT) is associated with an increased risk of deep vein thrombosis (DVT), it is not clear if the risk differs in users of combined estrogen-progestin HRT and estrogen-only HRT...
  61. ncbi request reprint Increased mortality in hemodialysis patients having specific antibodies to the platelet factor 4-heparin complex
    M Carrier
    Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Kidney Int 73:213-9. 2008
    ..Our study suggests that IgG-specific PF4-H antibody formation is associated with increased mortality in hemodialysis patients...
  62. ncbi request reprint Long-term dalteparin in pregnancy not associated with a decrease in bone mineral density: substudy of a randomized controlled trial
    M A Rodger
    Ottawa Health Research Institute, University of Ottawa, Ottawa, ON, Canada
    J Thromb Haemost 5:1600-6. 2007
    ..The risk of decreased bone mineral density (BMD) with prophylactic dose long-term low-molecular-weight heparin (LMWH) is unknown...
  63. ncbi request reprint Frequently relapsing thrombotic thrombocytopenic purpura treated with cytotoxic immunosuppressive therapy
    D S Allan
    Divison of Hematology, Department of Medicine, University of Western Ontario, London, Ontario, Canada
    Haematologica 86:844-50. 2001
    ..Immunosuppression, thus, has a biologically plausible role in TTP. We describe three consecutive cases of relapsing TTP treated with cytotoxic therapy to highlight the potential role of immunosuppression...
  64. doi request reprint Inter-observer reliability of measures to assess the post-thrombotic syndrome
    Marc A Rodger
    Thromb Haemost 100:164-6. 2008
  65. ncbi request reprint Comparison of low-intensity warfarin therapy with conventional-intensity warfarin therapy for long-term prevention of recurrent venous thromboembolism
    Clive Kearon
    McMaster University, Hamilton, Ont
    N Engl J Med 349:631-9. 2003
    ..After three months of conventional warfarin therapy, a lower dose of anticoagulant medication may result in less bleeding and still prevent recurrent venous thromboembolism...
  66. pmc Comparing the quality of oral anticoagulant management by anticoagulation clinics and by family physicians: a randomized controlled trial
    S Jo Anne Wilson
    Department of Pharmacy, Queen Elizabeth II Health Sciences Centre and Dalhousie University, Halifax, NS
    CMAJ 169:293-8. 2003
    ..We carried out a randomized controlled trial to evaluate these 2 models of anticoagulant care...
  67. ncbi request reprint The effect of dalteparin on coagulation activation during pregnancy in women with thrombophilia. A randomized trial
    Karim Abou-Nassar
    The Ottawa Hospital, General Campus, 501 Smyth Road, Box 201, Ottawa, ONT K1H 8L6, Canada
    Thromb Haemost 98:163-71. 2007
    ..Prophylaxis with dalteparin at doses used in this study did not reduce coagulation activation in high risk thrombophilic women during pregnancy...
  68. ncbi request reprint A randomised comparison of melphalan with prednisone or dexamethasone as induction therapy and dexamethasone or observation as maintenance therapy in multiple myeloma: NCIC CTG MY.7
    Chaim Shustik
    Royal Victoria Hospital, Montreal, QC, Canada
    Br J Haematol 136:203-11. 2007
    ..Dexamethasone did not improve clinical outcome when combined with melphalan during induction; maintenance dexamethasone improved PFS, but this did not translate into a detectable survival advantage...
  69. ncbi request reprint Standard-intensity vs low-dose anticoagulation for long-term management of patients with venous thromboembolism
    Alejandro Lazo-Langner
    The Ottawa Hospital, Department of Epidemiology and Community Medicine, University of Ottawa
    Clin Adv Hematol Oncol 3:877-9. 2005
  70. ncbi request reprint A randomized trial comparing 2 low-molecular-weight heparins for the outpatient treatment of deep vein thrombosis and pulmonary embolism
    Philip S Wells
    Departments of Medicine, University of Ottawa, Ottawa Health Research Institute, Ottawa, Ontario
    Arch Intern Med 165:733-8. 2005
    ..No published trials have compared LMWHs, and few studies have examined outpatient therapy for PE. Only tinzaparin sodium has demonstrated superiority to unfractionated heparin in a clinical trial...
  71. ncbi request reprint Deep vein thrombosis
    Clive Kearon
    Lancet 366:118; author reply 119-20. 2005
  72. ncbi request reprint Timing of hypercoagulable screens
    Michael J Kovacs
    Arch Intern Med 162:613-4. 2002