Affiliation: University of Ottawa
- Central cholecystokinin activity in irritable bowel syndrome, panic disorder, and healthy controlsDiana Koszycki
Department of Psychiatry, University of Ottawa, and the University of Ottawa Institute of Mental Health Research, Royal Ottawa Hospital, Ottawa, Ontario, Canada
Psychosom Med 67:590-5. 2005..To test this hypothesis, we assessed whether the enhanced panicogenic response to CCK-tetrapeptide (CCK-4) observed in PD is also present in IBS...
- Lack of association between the corticotrophin-releasing hormone receptor 2 gene and panic disorderSubi Tharmalingam
Neurogenetics Section, Centre for Addiction and Mental Health, University of Toronto, Canada
Psychiatr Genet 16:93-7. 2006..Further studies investigating additional polymorphisms in this gene and other components of the CRH signalling system may prove useful...
- Sensitivity to cholecystokinin-tetrapeptide in major depressionDiana Koszycki
Department of Psychiatry, University of Ottawa, and the Stress and Anxiety Clinical Research Unit, Institute of Mental Health Research, Royal Ottawa Hospital, 1145 Carling Avenue, Ottawa, ON K1Z 7K4, Canada
J Affect Disord 80:285-90. 2004..In the present study, we determined whether sensitivity to CCK-4 is enhanced in patients with major depressive disorder (MDD) with no history of panic attacks. We also determined whether CCK-4 would exacerbate depressive symptoms...
- Randomized trial of a meditation-based stress reduction program and cognitive behavior therapy in generalized social anxiety disorderDiana Koszycki
Stress and Anxiety Clinical Research Unit, University of Ottawa Institute of Mental Health Research, Royal Ottawa Mental Health Centre, 1145 Carling Ave, Ottawa, Ont, Canada K1Z 7K4
Behav Res Ther 45:2518-26. 2007..The results confirm that CBGT is the treatment of choice of generalized SAD and suggest that MBSR may have some benefit in the treatment of generalized SAD...
- An open-label trial of interpersonal psychotherapy in depressed patients with coronary diseaseDiana Koszycki
University of Ottawa Heart Institute and the Institute of Mental Health Research, Royal Ottawa Hospital, ONT Canada
Psychosomatics 45:319-24. 2004..The therapy was well tolerated and accepted by patients, with a high proportion achieving remission. Future randomized clinical trials are needed to establish its efficacy...
- Behavioral, cardiovascular, and neuroendocrine profiles following CCK-4 challenge in healthy volunteers: a comparison of panickers and nonpanickersD Koszycki
Stress and Anxiety Clinical Research Unit, Royal Ottawa Hospital, Ontario, Canada
Depress Anxiety 8:1-7. 1998....
- Anxiety sensitivity does not predict fearful responding to 35% carbon dioxide in patients with panic disorderD Koszycki
Stress and Anxiety Clinical Research Unit, Royal Ottawa Hospital, 1145 Carling Avenue, K1Z 7K4, Ottawa, Canada
Psychiatry Res 101:137-43. 2001..Overall, these data do not support the view that anxiety sensitivity plays a key role in mediating behavioural sensitivity to CO(2) inhalation in panic disorder...
- Effects of CCK-4 infusion on the acoustic eye-blink startle and psychophysiological measures in healthy volunteersJ Shlik
Royal Ottawa Hospital, University of Ottawa, Ontario, Canada
J Psychopharmacol 13:385-90. 1999..The results of this study show that a prolonged intravenous administration of CCK-4 may be a useful challenge method for further studies on the role of CCK system in the modulation of human anxiety and stress response...
- Effect of aging on cholecystokinin-induced panicA J Flint
Department of Psychiatry, University of Toronto, Quebec, Canada
Am J Psychiatry 155:283-5. 1998..The goal of this study was to determine whether aging has an effect on healthy subjects' responses to the panicogenic agent cholecystokinin tetrapeptide (CCK-4)...
- Investigation of cholecystokinin system genes in panic disorderJ L Kennedy
Clarke Division, Centre for Addiction and Mental Health, University of Toronto, Ontario, Canada
Mol Psychiatry 4:284-5. 1999..Our genetic dissection of the CCK system thus far suggests that the CCK-B receptor gene variation may contribute to the neurobiology of panic disorder...
- Neurohormonal responses to cholecystokinin tetrapeptide: a comparison of younger and older healthy subjectsA J Flint
The Department of Psychiatry, University of Toronto, Ontario, Canada
Psychoneuroendocrinology 25:633-47. 2000..For the most part, maximum changes in hormonal levels were not correlated with symptom severity, suggesting that other factors may have contributed to the differential effect of panic on the HPA axis...
- A double-blind, placebo-controlled study on the effects of Gotu Kola (Centella asiatica) on acoustic startle response in healthy subjectsJ Bradwejn
Royal Ottawa Hospital and the Department of Psychiatry, University of Ottawa, Ontario, Canada
J Clin Psychopharmacol 20:680-4. 2000..These preliminary findings suggest that Gotu Kola has anxiolytic activity in humans as revealed by the ASR. It remains to be seen whether this herb has therapeutic efficacy in the treatment of anxiety syndromes...
- Arginine-vasopressin and oxytocin response to cholecystokinin-tetrapeptideJ M Le Melledo
Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada
Peptides 22:1349-57. 2001..AVP and OT may play a role in the hypothalamo-pituitary adrenal (HPA) axis activity associated with the panic response induced by CCK-4...
- Behavioral, neurochemical, anatomical and electrophysiological correlates of panic disorder: multiple transmitter interaction and neuropeptide colocalizationR M Zacharko
Psychology Department, Carleton University, Ottawa, Ontario, Canada
Prog Neurobiol 47:371-423. 1995..Such variables presumably underlie the diverse behavioral symptoms associated with panic disorder and variations in the therapeutic efficacy of pharmacological treatment...
- Decrease in short-term memory function induced by CCK-4 in healthy volunteersJ Shlik
Stress and Anxiety Clinical Research Unit, Royal Ottawa Hospital, University of Ottawa, Ontario, Canada
Peptides 19:969-75. 1998..The results of this study indicate that CCK-4 may exert a negative influence on memory consolidation and retrieval...
- Effects of cholecystokinin tetrapeptide on respiratory function in healthy volunteersJ Bradwejn
Department of Psychiatry and Meakins Christie Laboratories, McGill University, Montreal, Canada
Am J Psychiatry 155:280-2. 1998..The authors evaluated respiratory response to cholecystokinin tetrapeptide (CCK-4) in healthy volunteers...
- Association study of serotonin-2A receptor gene polymorphism and panic disorder in patients from Canada and GermanyC Rothe
Department of Psychiatry, University of Ottawa and the University of Ottawa Institute of Mental Health Research, Royal Ottawa Hospital, Ottawa, Canada
Neurosci Lett 363:276-9. 2004..Our data suggest thus that this polymorphism is unlikely to play a major role in the pathogenesis of panic disorder...
- A randomized trial of sertraline, self-administered cognitive behavior therapy, and their combination for panic disorderD Koszycki
Faculty of Education, University of Ottawa, ON, Canada
Psychol Med 41:373-83. 2011..However, it is unknown whether combining SCBT and antidepressants can improve treatment. This trial evaluated the efficacy of SCBT and sertraline, alone or in combination, in PD...
- Cholecystokinin and panic disorder: past and future clinical research strategiesJ Bradwejn
Department of Psychiatry, University of Ottawa and the Royal Ottawa Hospital, Ontario, Canada
Scand J Clin Lab Invest Suppl 234:19-27. 2001....
- Effects of CCK-tetrapeptide in patients with social phobia and obsessive-compulsive disorderMartin A Katzman
Centre for Addiction and Mental Health Clarke Division and the Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
Depress Anxiety 20:51-8. 2004..The lack of effect of CCK-4 on SP and OCD symptoms suggests that this peptide does not play a salient role in the pathophysiology of these disorders...
- A multifaith spiritually based intervention for generalized anxiety disorder: a pilot randomized trialDiana Koszycki
Faculty of Education, University of Ottawa, Ontario, Canada
J Clin Psychol 66:430-41. 2010..These preliminary findings are encouraging and suggest that a multifaith SBI may be an effective treatment option for GAD. Further randomized controlled trials are needed to establish the efficacy of this intervention...
- Aging and panicogenic response to cholecystokinin tetrapeptide: an examination of the cholecystokinin systemAlastair Flint
Toronto General Hospital, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
Neuropsychopharmacology 27:663-71. 2002..These findings are consistent with our hypothesis and suggest that age-related changes in the CCK system could contribute to the diminished panicogenic response to exogenous CCK-4 in older persons...
- Evaluation of anxiolytic properties of Gotukola--(Centella asiatica) extracts and asiaticoside in rat behavioral modelsP Wijeweera
Ottawa Carleton Institute of Biology, University of Ottawa Institute of Mental Health Research, Royal Ottawa Hospital, Canada
Phytomedicine 13:668-76. 2006..Furthermore, the asiaticoside did not affect locomotor activity, suggesting these compounds do not have sedative effects in rodents...
- Prenatal social support, postnatal social support, and postpartum depressionRi Hua Xie
OMNI Research Group, Department of Obstetrics and Gynecology, University of Ottawa, Ottawa, Ontario, Canada
Ann Epidemiol 19:637-43. 2009..To assess the association of antenatal and postnatal social support with postpartum depression (PPD)...
- Effects of citalopram and interpersonal psychotherapy on depression in patients with coronary artery disease: the Canadian Cardiac Randomized Evaluation of Antidepressant and Psychotherapy Efficacy (CREATE) trialFrancois Lesperance
Department of Psychiatry, Universite de Montreal, Montreal, Quebec, Canada
JAMA 297:367-79. 2007..Few randomized controlled trials have evaluated the efficacy of treatments for major depression in patients with coronary artery disease (CAD). None have simultaneously evaluated an antidepressant and short-term psychotherapy...
- Gender differences in anxiety-related traits in patients with panic disorderMeredith Foot
University of Ottawa Institute of Mental Health Research, Royal Ottawa Hospital, Ottawa, Canada
Depress Anxiety 20:123-30. 2004..These findings suggest that gender differences exist among patients with PD+/-AG in the feared consequences of anxiety symptoms as well as in the personality characteristics of extraversion...
- Association of the Val158Met catechol O-methyltransferase genetic polymorphism with panic disorderClaudia Rothe
Clarke Division, Centre for Addiction and Mental Health, University of Toronto, Toronto, and the University of Ottawa Institute of Mental Health Research, Royal Ottawa Hospital, ON, Canada
Neuropsychopharmacology 31:2237-42. 2006..No significant results were found for the other two markers. These results support the hypothesis that the valine allele of the Val158Met COMT polymorphism or a nearby locus is involved in the etiopathogenesis of panic disorder...
- Design and rationale for a randomized, controlled trial of interpersonal psychotherapy and citalopram for depression in coronary artery disease (CREATE)Nancy Frasure-Smith
Department of Psychiatry, McGill University, Montreal Canada
Psychosom Med 68:87-93. 2006....