Svetlana V Komarova

Summary

Affiliation: University of Western Ontario
Country: Canada

Publications

  1. ncbi request reprint Mathematical model predicts a critical role for osteoclast autocrine regulation in the control of bone remodeling
    Svetlana V Komarova
    CIHR Group in Skeletal Development and Remodeling, Department of Physiology and Pharmacology, Faculty of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada N6A 5C1
    Bone 33:206-15. 2003
  2. pmc Convergent signaling by acidosis and receptor activator of NF-kappaB ligand (RANKL) on the calcium/calcineurin/NFAT pathway in osteoclasts
    Svetlana V Komarova
    Canadian Institutes of Health Research Group in Skeletal Development and Remodeling, Department of Physiology and Pharmacology, Faculty of Medicine and Dentistry, University of Western Ontario, London, ON, Canada N6A 5C1
    Proc Natl Acad Sci U S A 102:2643-8. 2005
  3. ncbi request reprint Extracellular acidification enhances osteoclast survival through an NFAT-independent, protein kinase C-dependent pathway
    Alexey Pereverzev
    CIHR Group in Skeletal Development and Remodeling, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada N6A 5C1
    Bone 42:150-61. 2008
  4. ncbi request reprint RANK ligand-induced elevation of cytosolic Ca2+ accelerates nuclear translocation of nuclear factor kappa B in osteoclasts
    Svetlana V Komarova
    CIHR Group in Skeletal Development and Remodeling, Department of Physiology and Pharmacology, Faculty of Medicine and Dentistry, The University of Western Ontario, London, Canada
    J Biol Chem 278:8286-93. 2003
  5. ncbi request reprint Mathematical model of paracrine interactions between osteoclasts and osteoblasts predicts anabolic action of parathyroid hormone on bone
    Svetlana V Komarova
    Faculty of Dentistry, McGill University, 3640 University Street, Montreal, Quebec, Canada H3A 2B2
    Endocrinology 146:3589-95. 2005
  6. ncbi request reprint Bone remodeling in health and disease: lessons from mathematical modeling
    Svetlana V Komarova
    Faculty of Dentistry, McGill University, 3640 University Street, Montreal, QC, Canada H3A 2B2
    Ann N Y Acad Sci 1068:557-9. 2006
  7. doi request reprint The use of RANKL-coated brushite cement to stimulate bone remodelling
    Damien Le Nihouannen
    Faculty of Dentistry, McGill University, 3640 University Street, Montreal, Quebec, Canada H3A 2B2
    Biomaterials 29:3253-9. 2008
  8. pmc Complex dynamics of osteoclast formation and death in long-term cultures
    Timur Akchurin
    Faculty of Dentistry, McGill University, Montreal, Quebec, Canada
    PLoS ONE 3:e2104. 2008
  9. doi request reprint Osteoclast precursors acquire sensitivity to breast cancer derived factors early in differentiation
    Yubin Guo
    Faculty of Dentistry, McGill University, Montreal, Quebec, Canada
    Bone 43:386-93. 2008

Collaborators

  • Stephen M Sims
  • Alexey Pereverzev
  • Yubin Guo
  • Timur Akchurin
  • Damien Le Nihouannen
  • Tayeb Aissiou
  • Uwe Gbureck
  • Erin Prosk
  • S Jeffrey Dixon
  • Kerstin Tiedemann
  • Gilles B Tremblay
  • Naomi Kemeny
  • S Adam Hacking
  • Jasminka Korcok
  • Jake E Barralet
  • Peter M Siegel
  • Souzan Armstrong
  • Nilima Nigam
  • Jad Abou Khalil
  • Caterina Russo

Detail Information

Publications9

  1. ncbi request reprint Mathematical model predicts a critical role for osteoclast autocrine regulation in the control of bone remodeling
    Svetlana V Komarova
    CIHR Group in Skeletal Development and Remodeling, Department of Physiology and Pharmacology, Faculty of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada N6A 5C1
    Bone 33:206-15. 2003
    ....
  2. pmc Convergent signaling by acidosis and receptor activator of NF-kappaB ligand (RANKL) on the calcium/calcineurin/NFAT pathway in osteoclasts
    Svetlana V Komarova
    Canadian Institutes of Health Research Group in Skeletal Development and Remodeling, Department of Physiology and Pharmacology, Faculty of Medicine and Dentistry, University of Western Ontario, London, ON, Canada N6A 5C1
    Proc Natl Acad Sci U S A 102:2643-8. 2005
    ..In summary, acidification and RANKL induce signals in osteoclasts that converge on the Ca2+/calcineurin/NFAT pathway. Acidosis acts directly on osteoclasts to activate NFATc1 and stimulate resorption...
  3. ncbi request reprint Extracellular acidification enhances osteoclast survival through an NFAT-independent, protein kinase C-dependent pathway
    Alexey Pereverzev
    CIHR Group in Skeletal Development and Remodeling, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada N6A 5C1
    Bone 42:150-61. 2008
    ..Thus, this study reveals that extracellular acidification enhances osteoclast survival through an NFAT-independent, PKC-dependent pathway. Increased osteoclast survival may contribute to bone loss in systemic and local acidosis...
  4. ncbi request reprint RANK ligand-induced elevation of cytosolic Ca2+ accelerates nuclear translocation of nuclear factor kappa B in osteoclasts
    Svetlana V Komarova
    CIHR Group in Skeletal Development and Remodeling, Department of Physiology and Pharmacology, Faculty of Medicine and Dentistry, The University of Western Ontario, London, Canada
    J Biol Chem 278:8286-93. 2003
    ..Such cross-talk between NFkappaB and Ca(2+) signaling provides a novel mechanism for the temporal regulation of gene expression in osteoclasts and other cell types...
  5. ncbi request reprint Mathematical model of paracrine interactions between osteoclasts and osteoblasts predicts anabolic action of parathyroid hormone on bone
    Svetlana V Komarova
    Faculty of Dentistry, McGill University, 3640 University Street, Montreal, Quebec, Canada H3A 2B2
    Endocrinology 146:3589-95. 2005
    ..This study presents an original concept for the regulation of bone remodeling by PTH, currently the only approved anabolic treatment for osteoporosis...
  6. ncbi request reprint Bone remodeling in health and disease: lessons from mathematical modeling
    Svetlana V Komarova
    Faculty of Dentistry, McGill University, 3640 University Street, Montreal, QC, Canada H3A 2B2
    Ann N Y Acad Sci 1068:557-9. 2006
    ..This study provides a novel conceptual framework for the development of highly desirable anabolic treatments for bone diseases...
  7. doi request reprint The use of RANKL-coated brushite cement to stimulate bone remodelling
    Damien Le Nihouannen
    Faculty of Dentistry, McGill University, 3640 University Street, Montreal, Quebec, Canada H3A 2B2
    Biomaterials 29:3253-9. 2008
    ..Thus, we developed a formulation of brushite cement with RANKL - a synthetic bone graft that is similar to autografts in its ability to actively induce osteoclastogenesis...
  8. pmc Complex dynamics of osteoclast formation and death in long-term cultures
    Timur Akchurin
    Faculty of Dentistry, McGill University, Montreal, Quebec, Canada
    PLoS ONE 3:e2104. 2008
    ..We aimed to investigate the dynamics of osteoclast formation and death in cultures that considerably exceeded the length of standard protocol and to design a mathematical model describing osteoclastogenesis...
  9. doi request reprint Osteoclast precursors acquire sensitivity to breast cancer derived factors early in differentiation
    Yubin Guo
    Faculty of Dentistry, McGill University, Montreal, Quebec, Canada
    Bone 43:386-93. 2008
    ..Our data suggest that, during differentiation, osteoclast precursors acquire the competency to respond to factors secreted by breast cancer cells, which may serve to promote tumor growth at skeletal sites undergoing active bone turnover...