Kohei Koga

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. pmc Glutamate acts as a neurotransmitter for gastrin releasing peptide-sensitive and insensitive itch-related synaptic transmission in mammalian spinal cord
    Kohei Koga
    Department of Physiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Pain 7:47. 2011
  2. pmc In vivo whole-cell patch-clamp recording of sensory synaptic responses of cingulate pyramidal neurons to noxious mechanical stimuli in adult mice
    Kohei Koga
    Department of Physiology, Faculty of Medicine, University of Toronto, Medical Science Building, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Pain 6:62. 2010
  3. doi request reprint Identification of an adenylyl cyclase inhibitor for treating neuropathic and inflammatory pain
    Hansen Wang
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, Medical Sciences Building, 1 King s College Circle, Toronto, Ontario M5S1A8, Canada
    Sci Transl Med 3:65ra3. 2011
  4. doi request reprint Cortical GluK1 kainate receptors modulate scratching in adult mice
    Giannina Descalzi
    Department of Physiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, University of Toronto Center for the Study of Pain, Toronto, Ontario, Canada
    J Neurochem 126:636-50. 2013
  5. pmc Interplay of amygdala and cingulate plasticity in emotional fear
    Hiroki Toyoda
    Department of Physiology, University of Toronto, Toronto, ON, Canada
    Neural Plast 2011:813749. 2011
  6. pmc Rapid synaptic potentiation within the anterior cingulate cortex mediates trace fear learning
    Giannina Descalzi
    Department of Physiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Brain 5:6. 2012
  7. doi request reprint Alleviating neuropathic pain hypersensitivity by inhibiting PKMzeta in the anterior cingulate cortex
    Xiang yao Li
    Department of Physiology, Faculty of Medicine, Center for the Study of Pain, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Science 330:1400-4. 2010
  8. doi request reprint Kainate receptor-mediated synaptic transmissions in the adult rodent insular cortex
    Kohei Koga
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    J Neurophysiol 108:1988-98. 2012
  9. ncbi request reprint Long-term depression of synaptic transmission in the adult mouse insular cortex in vitro
    Ming Gang Liu
    Department of Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul, Korea Department of Physiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, Ontario, M5S 1A8, Canada
    Eur J Neurosci 38:3128-45. 2013
  10. pmc Spinal microglial motility is independent of neuronal activity and plasticity in adult mice
    Tao Chen
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, University of Toronto, Toronto, Ontario, Canada
    Mol Pain 6:19. 2010

Detail Information

Publications11

  1. pmc Glutamate acts as a neurotransmitter for gastrin releasing peptide-sensitive and insensitive itch-related synaptic transmission in mammalian spinal cord
    Kohei Koga
    Department of Physiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Pain 7:47. 2011
    ..Our results will help to understand the neuronal mechanism of itch and aid future treatment for patients with pruritic disease...
  2. pmc In vivo whole-cell patch-clamp recording of sensory synaptic responses of cingulate pyramidal neurons to noxious mechanical stimuli in adult mice
    Kohei Koga
    Department of Physiology, Faculty of Medicine, University of Toronto, Medical Science Building, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Pain 6:62. 2010
    ..Our studies provide the first in vivo characterization of ACC neurons in adult mice, and demonstrate that ACC neurons are indeed nociceptive. These findings support the critical roles of ACC in nociception, from mice to humans...
  3. doi request reprint Identification of an adenylyl cyclase inhibitor for treating neuropathic and inflammatory pain
    Hansen Wang
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, Medical Sciences Building, 1 King s College Circle, Toronto, Ontario M5S1A8, Canada
    Sci Transl Med 3:65ra3. 2011
    ..Our study thus shows that AC1 could be a productive therapeutic target for neuropathic pain and describes a new agent for the possible treatment of neuropathic pain...
  4. doi request reprint Cortical GluK1 kainate receptors modulate scratching in adult mice
    Giannina Descalzi
    Department of Physiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, University of Toronto Center for the Study of Pain, Toronto, Ontario, Canada
    J Neurochem 126:636-50. 2013
    ..In addition, we found that inhibiting GluK1-containing KA receptors in the ACC also reduced behavioral nociceptive responses induced by formalin. Our results reveal a new role of the cortex in pruritogen-induced scratching...
  5. pmc Interplay of amygdala and cingulate plasticity in emotional fear
    Hiroki Toyoda
    Department of Physiology, University of Toronto, Toronto, ON, Canada
    Neural Plast 2011:813749. 2011
    ....
  6. pmc Rapid synaptic potentiation within the anterior cingulate cortex mediates trace fear learning
    Giannina Descalzi
    Department of Physiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Brain 5:6. 2012
    ....
  7. doi request reprint Alleviating neuropathic pain hypersensitivity by inhibiting PKMzeta in the anterior cingulate cortex
    Xiang yao Li
    Department of Physiology, Faculty of Medicine, Center for the Study of Pain, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Science 330:1400-4. 2010
    ..Microinjection of ZIP into the ACC blocked behavioral sensitization. These results suggest that PKMĪ¶ in the ACC acts to maintain neuropathic pain. PKMĪ¶ could thus be a new therapeutic target for treating chronic pain...
  8. doi request reprint Kainate receptor-mediated synaptic transmissions in the adult rodent insular cortex
    Kohei Koga
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    J Neurophysiol 108:1988-98. 2012
    ..These data suggest that both GluK1 and GluK2 play functional roles in the IC. Our study may provide the synaptic basis for the physiology and pathology of KA receptors in the IC-related functions...
  9. ncbi request reprint Long-term depression of synaptic transmission in the adult mouse insular cortex in vitro
    Ming Gang Liu
    Department of Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul, Korea Department of Physiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, Ontario, M5S 1A8, Canada
    Eur J Neurosci 38:3128-45. 2013
    ..Our studies have characterised the basic mechanisms of LTD in the IC at the network level, and suggest that two different forms of LTD may co-exist in the same population of IC synapses. ..
  10. pmc Spinal microglial motility is independent of neuronal activity and plasticity in adult mice
    Tao Chen
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, University of Toronto, Toronto, Ontario, Canada
    Mol Pain 6:19. 2010
    ....
  11. pmc Direct inhibition of substantia gelatinosa neurones in the rat spinal cord by activation of dopamine D2-like receptors
    Akihiro Tamae
    Department of Physiology, Faculty of Medicine, Saga University, Saga 849 8501, Japan
    J Physiol 568:243-53. 2005
    ..This may be a possible mechanism for antinociception by the descending dopaminergic pathway...