V J Knott

Summary

Affiliation: University of Ottawa
Country: Canada

Publications

  1. ncbi Clonidine pre-treatment fails to block acute smoking-induced EEG arousal/mood in cigarette smokers
    Verner J Knott
    Department of Psychiatry, University of Ottawa and Institute of Mental Health Research Royal Ottawa Hospital, 1145 Carling Avenue, Ottawa, Ontario, Canada K1Z 7K4
    Pharmacol Biochem Behav 80:161-71. 2005
  2. ncbi Acute nicotine fails to alter event-related potential or behavioral performance indices of auditory distraction in cigarette smokers
    Verner J Knott
    University of Ottawa Institute of Mental Health Research, Royal Ottawa Hospital, Ottawa, Ontario, Canada
    Nicotine Tob Res 8:263-73. 2006
  3. ncbi Acute cholecystokinin effects on event-related potentials in healthy volunteers
    Verner J Knott
    Department of Psychiatry, University of Ottawa and Royal Ottawa Hospital Institute of Mental Health Research, Ottawa, Ontario, Canada
    Hum Psychopharmacol 17:285-91. 2002
  4. ncbi EEG coherence following acute and chronic clozapine in treatment-resistant schizophrenics
    Verner J Knott
    Department of Psychiatry and Psychology, University of Ottawa Royal Ottawa Hospital, Ontario, Canada
    Exp Clin Psychopharmacol 10:435-44. 2002
  5. ncbi Effects of stimulus modality and response mode on the P300 event-related potential differentiation of young and elderly adults
    Verner Knott
    Department of Psychiatry, University of Ottawa, Institute of Mental Health Research Royal Ottawa Hospital, Ottawa, Canada
    Clin Electroencephalogr 34:182-90. 2003
  6. doi Sensory gating and source analysis of the auditory P50 in low and high suppressors
    Verner Knott
    University of Ottawa Institute of Mental Health Research, Ottawa, ON, Canada
    Neuroimage 44:992-1000. 2009
  7. ncbi Effects of acute cholecystokinin infusion on hemispheric EEG asymmetry and coherence in healthy volunteers
    Verner Knott
    Department of Psychiatry, University of Ottawa, Ottawa, Ontario, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 27:179-84. 2003
  8. doi Electrophysiological evidence of nicotine's distracter-filtering properties in non-smokers
    Verner Knott
    Clinical Neuroelectrophysiological and Cognitive Research Laboratory, University of Ottawa Institute of Mental Health Research, Royal Ottawa Mental Health Centre, Ottawa, ON, Canada
    J Psychopharmacol 25:239-48. 2011
  9. ncbi Event-related potentials in young and elderly adults during a visual spatial working memory task
    Verner Knott
    Department of Psychiatry, University of Ottawa, Canada
    Clin EEG Neurosci 35:185-92. 2004
  10. ncbi Neural effects of nicotine during auditory selective attention in smokers: an event-related potential study
    Verner Knott
    University of Ottawa Institute of Mental Health Research, Ottawa, Canada
    Neuropsychobiology 53:115-26. 2006

Collaborators

Detail Information

Publications40

  1. ncbi Clonidine pre-treatment fails to block acute smoking-induced EEG arousal/mood in cigarette smokers
    Verner J Knott
    Department of Psychiatry, University of Ottawa and Institute of Mental Health Research Royal Ottawa Hospital, 1145 Carling Avenue, Ottawa, Ontario, Canada K1Z 7K4
    Pharmacol Biochem Behav 80:161-71. 2005
    ..The results are discussed in relation to neural mechanisms underlying the acute reinforcement maintaining nicotine use...
  2. ncbi Acute nicotine fails to alter event-related potential or behavioral performance indices of auditory distraction in cigarette smokers
    Verner J Knott
    University of Ottawa Institute of Mental Health Research, Royal Ottawa Hospital, Ottawa, Ontario, Canada
    Nicotine Tob Res 8:263-73. 2006
    ..Results are discussed in relation to a stimulus-filter model of smoking and in relation to future research directions...
  3. ncbi Acute cholecystokinin effects on event-related potentials in healthy volunteers
    Verner J Knott
    Department of Psychiatry, University of Ottawa and Royal Ottawa Hospital Institute of Mental Health Research, Ottawa, Ontario, Canada
    Hum Psychopharmacol 17:285-91. 2002
    ..These preliminary findings suggest that CCK-4 may interfere with information processing relating to the selection of significant stimuli and as such, may be of relevance to mechanisms underlying panic disorder...
  4. ncbi EEG coherence following acute and chronic clozapine in treatment-resistant schizophrenics
    Verner J Knott
    Department of Psychiatry and Psychology, University of Ottawa Royal Ottawa Hospital, Ontario, Canada
    Exp Clin Psychopharmacol 10:435-44. 2002
    ..Findings are discussed in relation to "disconnection" theories of schizophrenia...
  5. ncbi Effects of stimulus modality and response mode on the P300 event-related potential differentiation of young and elderly adults
    Verner Knott
    Department of Psychiatry, University of Ottawa, Institute of Mental Health Research Royal Ottawa Hospital, Ottawa, Canada
    Clin Electroencephalogr 34:182-90. 2003
    ..Implications of the findings are discussed in relation to P300 applications in the clinical assessment of dementia and aging-associated cognitive alterations...
  6. doi Sensory gating and source analysis of the auditory P50 in low and high suppressors
    Verner Knott
    University of Ottawa Institute of Mental Health Research, Ottawa, ON, Canada
    Neuroimage 44:992-1000. 2009
    ..These findings suggest that impaired gating of the kind evident in schizophrenia may involve the deficient functioning of multiple interconnected and temporally overlapping activated brain regions...
  7. ncbi Effects of acute cholecystokinin infusion on hemispheric EEG asymmetry and coherence in healthy volunteers
    Verner Knott
    Department of Psychiatry, University of Ottawa, Ottawa, Ontario, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 27:179-84. 2003
    ..These findings support the contention that functional imbalance of the temporal cortex, perhaps mediated by CCK-4, is involved in panic disorder (PD)...
  8. doi Electrophysiological evidence of nicotine's distracter-filtering properties in non-smokers
    Verner Knott
    Clinical Neuroelectrophysiological and Cognitive Research Laboratory, University of Ottawa Institute of Mental Health Research, Royal Ottawa Mental Health Centre, Ottawa, ON, Canada
    J Psychopharmacol 25:239-48. 2011
    ..These findings and the behavioral-electrophysiological dissociation seen with nicotine are discussed in relation to theories of attention and smoking motivation...
  9. ncbi Event-related potentials in young and elderly adults during a visual spatial working memory task
    Verner Knott
    Department of Psychiatry, University of Ottawa, Canada
    Clin EEG Neurosci 35:185-92. 2004
    ....
  10. ncbi Neural effects of nicotine during auditory selective attention in smokers: an event-related potential study
    Verner Knott
    University of Ottawa Institute of Mental Health Research, Ottawa, Canada
    Neuropsychobiology 53:115-26. 2006
    ..The findings are discussed in relation to the stimulus filter theory of smoking, and with respect to nicotine's actions on involuntary and controlled aspects of selective attention processes...
  11. ncbi Nicotine and smoker status moderate brain electric and mood activation induced by ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist
    V Knott
    Clinical Neuroelectrophysiology and Cognitive Research Laboratory, University of Ottawa Institute of Mental Health Research, Royal Ottawa Hospital, Ottawa, ON, Canada
    Pharmacol Biochem Behav 85:228-42. 2006
    ....
  12. ncbi Naltrexone alteration of the nicotine-induced EEG and mood activation response in tobacco-deprived cigarette smokers
    Verner J Knott
    University of Ottawa Institute of Mental Health Research, Ottawa, ON, Canada
    Exp Clin Psychopharmacol 15:368-81. 2007
    ..These findings suggest that the opioid system is involved in nicotine-induced subjective and neuroelectric arousal and implicate opioid-cholinergic interactions in the elicitation of these arousal responses to nicotine...
  13. ncbi EEG correlates of imagery-induced cigarette craving in male and female smokers
    Verner Knott
    Royal Ottawa Mental Health Centre, Ottawa, Ontario, Canada
    Addict Behav 33:616-21. 2008
    ..This imagery-elicited neuroelectric profile, appearing to reflect opposing actions of reward and withdrawal, suggests that EEG may be a sensitive tool for probing the multidimensional nature of craving...
  14. doi Effects of acute nicotine on event-related potential and performance indices of auditory distraction in nonsmokers
    Verner J Knott
    Clinical Neuroelectrophysiology and Cognitive Research Laboratory, University of Ottawa Institute of Mental Health Research, Royal Ottawa Mental Health Centre, 1145 Carling Avenue, Ottawa, Ontario K1Z 7K4, Canada
    Nicotine Tob Res 11:519-30. 2009
    ....
  15. doi Craving-induced EEG reactivity in smokers: effects of mood induction, nicotine dependence and gender
    Verner J Knott
    Clinical Neuroelectrophysiology and Cognitive Research Laboratory, University of Ottawa Institute of Mental Health Research, Ottawa, Ont, Canada
    Neuropsychobiology 58:187-99. 2008
    ....
  16. ncbi EEG correlates of acute and chronic paroxetine treatment in depression
    Verner Knott
    Department of Psychiatry and Psychology, University of Ottawa Royal Ottawa Hospital and Institute of Mental Health Research, Ottawa, ON, Canada
    J Affect Disord 69:241-9. 2002
    ..The chronic pharmaco-EEG response pattern reflects both sedating and activating actions in regional specific areas which are relevant to the pathophysiology and the pharmacotherapeutic treatment of depression...
  17. ncbi Effects of acute nicotine administration on cognitive event-related potentials in tacrine-treated and non-treated patients with Alzheimer's disease
    V Knott
    Department of Psychiatry, University of Ottawa Royal Ottawa Hospital and Institute of Mental Health Research, Ottawa, Ontario, Canada
    Neuropsychobiology 45:156-60. 2002
    ..Neither THA treatment nor single-dose nicotine altered behavioural performance in the visual and auditory task paradigms. The results are discussed in relation to nicotinic cholinergic, attentional and cognitive processes in DAT...
  18. ncbi Relaxation-induced EEG alterations in panic disorder patients
    V Knott
    Department of Psychiatry, University of Ottawa, Royal Ottawa Hospital, Ontario, Canada
    J Anxiety Disord 11:365-76. 1997
    ..High frequency beta activity was less evident in patients, regardless of tape conditions. Results are discussed in relation to arousal and treatment issues in panic disorder...
  19. ncbi Event-related potential correlates of primed and unprimed words in children co-morbid for disruptive behaviour disorders and academic delay
    V Knott
    Royal Ottawa Hospital, Department of Psychiatry, Ontario, Canada
    Eur Child Adolesc Psychiatry 7:209-18. 1998
    ..unprimed N400 amplitudes at either frontal, central or parietal sites. These findings suggest that DD-AD children may represent a unique neuroelectric subgroup of learning disabilities...
  20. ncbi Smoking history and aging-associated cognitive decline: An event-related brain potential study
    V J Knott
    Department of Psychiatry, University of Ottawa Royal Ottawa Hospital and Institute of Mental Health Research, Ottawa, Ont, Canada
    Neuropsychobiology 40:95-106. 1999
    ..Young smokers exhibited longer latencies than young nonsmokers. The results were discussed in relation to normal and pathological cognition in the elderly...
  21. ncbi Acute nicotine administration in Alzheimer's disease: an exploratory EEG study
    V Knott
    Department of Psychiatry, University of Ottawa Royal Ottawa Hospital and Institute of Mental Health Research, Ont, Canada
    Neuropsychobiology 41:210-20. 2000
    ..No differences were observed between treated and nontreated patients in response to nicotine. The results are discussed in relation to cholinergic and brain arousal systems and their relationship to cognitive processes...
  22. ncbi Pharmaco-EEG test dose response predicts cholinesterase inhibitor treatment outcome in Alzheimer's disease
    V Knott
    Department of Psychiatry and Psychology, University of Ottawa Royal Ottawa Hospital, Ontario, Canada
    Methods Find Exp Clin Pharmacol 22:115-22. 2000
    ..A discriminant analysis using test dose response EEG variables correctly classified 75-79% of these two patient groups, suggesting that this procedure may be a useful approach for optimizing patient selection for antidementia treatments...
  23. ncbi Pre-treatment EEG and it's relationship to depression severity and paroxetine treatment outcome
    V Knott
    Department of Psychiatry and Psychology, University of Ottawa Royal Ottawa Hospital and Institute of Mental Health Research, Ontario, Canada
    Pharmacopsychiatry 33:201-5. 2000
    ..Findings are discussed in relation to the neurochemistry and neurobiology of depressive disorders...
  24. ncbi Differential effects of nicotine on P50 amplitude, its gating, and their neural sources in low and high suppressors
    V J Knott
    University of Ottawa Institute of Mental Health Research, Ottawa, ON, Canada
    Neuroscience 170:816-26. 2010
    ....
  25. pmc Quantitative electroencephalography in Alzheimer's disease: comparison with a control group, population norms and mental status
    V Knott
    Department of Psychiatry and Psychology, University of Ottawa Royal Ottawa Hospital and Institute of Mental Health Research, Ottawa, Ont
    J Psychiatry Neurosci 26:106-16. 2001
    ....
  26. ncbi EEG power, frequency, asymmetry and coherence in male depression
    V Knott
    Department of Psychiatry and Psychology, University of Ottawa Royal Ottawa Hospital and Institute of Mental Health Research, 1145 Carling Avenue, Ontario, Ottawa, Canada
    Psychiatry Res 106:123-40. 2001
    ..3% of the patients and controls. Quantitative EEG measurements in male depression appear to describe a pattern of aberrant inter-hemispheric synchrony/asymmetry and a profile of frontal activation...
  27. ncbi Electroencephalographic characterization of cigarette smoking behavior
    V J Knott
    Department of Psychiatry, University of Ottawa, Ottawa, Ontario, Canada K1H 8L6
    Alcohol 24:95-7. 2001
    ..nonsmoker differences and the effects of chronic life-long smoking, provide objective insights into the neuroelectrophysiology underlying the smoking habit...
  28. ncbi Glucose and glucoregulatory modulation of memory scanning, event-related potentials and EEG in elderly subjects
    V Knott
    Department of Psychiatry and Psychology, University of Ottawa Royal Ottawa Hospital and Institute of Mental Health Research, Ottawa, Ont, Canada
    Neuropsychobiology 44:156-66. 2001
    ..The study results suggest that peripheral glucoregulation can influence neuroelectric measures of cognition and that the acute ingestion of glucose can modulate central arousal processes...
  29. doi Effects of nicotine on the amplitude and gating of the auditory P50 and its influence by dopamine D2 receptor gene polymorphism
    V Knott
    University of Ottawa Institute of Mental Health Research, Ottawa, ON, Canada
    Neuroscience 166:145-56. 2010
    ..These findings suggest that nicotine exerts mixed gating properties in healthy nicotine naive volunteers and that dopamine functions to alter both P50 and its gating as well as their response to acute nicotine agonist treatment...
  30. ncbi Quantitative EEG correlates of panic disorder
    V J Knott
    Department of Psychiatry, University of Ottawa Royal Ottawa Hospital, ON, Canada
    Psychiatry Res 68:31-9. 1996
    ..Absolute delta and theta power were positively correlated with observer ratings of anxiety, while relative beta power was related to self-ratings of anxiety...
  31. ncbi The cholinergic basis of the smoking-induced EEG activation profile
    V J Knott
    Department of Psychiatry, University of Ottawa Royal Ottawa Hospital and Institute of Mental Health Research, Ottawa, Ont, Canada
    Neuropsychobiology 38:97-107. 1998
    ..The results are discussed with respect to brain-behaviour relationships and mechanisms maintaining the smoking habit...
  32. doi Effects of nicotine on visuospatial attentional orienting in non-smokers
    D Impey
    University of Ottawa Institute of Mental Health Research, 1145 Carling Ave, Ottawa, ON K1Z 7K4, Canada
    Pharmacol Biochem Behav 106:1-7. 2013
    ..These results demonstrate support in general for the attentional effects of nicotine and nicotinic agonists and they specifically extend these effects to include orienting of visual-spatial attention...
  33. ncbi Effects of haloperidol pretreatment on the smoking-induced EEG/mood activation response profile
    D Walker
    Department of Psychology, Carleton University, Ottawa, Ontario, Canada
    Neuropsychobiology 43:102-12. 2001
    ..Discussion of these results focuses on transmitter systems and their relationship to neuro-electric and behavioural activities associated with the smoking habit...
  34. ncbi Acute nicotine effects on auditory sensory memory in tacrine-treated and nontreated patients with Alzheimer's disease: an event-related potential study
    C Engeland
    Department of Psychiatry and Psychology, University of Western Ontario, London, ON, Canada
    Pharmacol Biochem Behav 72:457-64. 2002
    ..These exploratory findings suggest that nicotine-improved strength of acoustic sensory memory traces and speed of acoustic sensory discrimination in AD are differentially affected by chronic tacrine treatment...
  35. doi Auditory hallucinations and the mismatch negativity: processing speech and non-speech sounds in schizophrenia
    Derek J Fisher
    Department of Psychology Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada
    Int J Psychophysiol 70:3-15. 2008
    ..Recent neuroimaging and behavioural evidence suggest a reciprocal relationship between auditory cortex response to external sounds versus that induced by AHs...
  36. doi The right profile: mismatch negativity in schizophrenia with and without auditory hallucinations as measured by a multi-feature paradigm
    Derek J Fisher
    Department of Psychology Institute of Neuroscience, Carleton University, Ottawa, Ont, Canada
    Clin Neurophysiol 119:909-21. 2008
    ..To examine pre-attentive acoustic change detection in schizophrenia patients with and without auditory hallucinations via mismatch negativity (MMN) extracted from a multi-feature paradigm...
  37. ncbi Light up and see: enhancement of the visual mismatch negativity (vMMN) by nicotine
    Derek J Fisher
    Department of Psychology Institute of Neuroscience, Carleton University, Ottawa, ON, Canada
    Brain Res 1313:162-71. 2010
    ..The findings are discussed in relation to attentional and neurobiological theories of nicotine dependence and of cognition in general...
  38. doi Auditory hallucinations and the P3a: attention-switching to speech in schizophrenia
    Derek J Fisher
    Department of Psychology Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada
    Biol Psychol 85:417-23. 2010
    ..Recent neuroimaging and behavioural evidence suggest altered early cognitive processes may be seen in patients with AH as a result of limited processing resources...
  39. doi Effects of deviant probability on the 'optimal' multi-feature mismatch negativity (MMN) paradigm
    Derek J Fisher
    Department of Psychology Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada
    Int J Psychophysiol 79:311-5. 2011
    ..The focus of this paper is two-fold: first, to examine the effects of altering deviant probability, but not standard probability, on MMN generation and, secondly, to validate a shorter, 3-stimulus version of the 'optimal' paradigm...
  40. ncbi Clinical and attentional effects of acute nicotine treatment in Tourette's syndrome
    Anne L Howson
    Adult Metabolic Disease Clinic, Vancouver General Hospital, Vancouver Coastal Health Authority, BC, Canada
    Eur Psychiatry 19:102-12. 2004
    ..Additional work with intermittent dosing schedules is required to characterize optimal clinical and cognitive effects with nicotine treatment...