Jeffrey A Kleim

Summary

Affiliation: University of Lethbridge
Country: Canada

Publications

  1. ncbi request reprint III STEP: a basic scientist's perspective
    Jeffrey A Kleim
    Phys Ther 86:614-7. 2006
  2. ncbi request reprint Motor map expansion following repeated cortical and limbic seizures is related to synaptic potentiation
    G Campbell Teskey
    Behavioural Neuroscience Research Group, Department of Psychology, University of Calgary, Calgary, Alberta, Canada T2N 1N4
    Cereb Cortex 12:98-105. 2002
  3. ncbi request reprint BDNF val66met polymorphism is associated with modified experience-dependent plasticity in human motor cortex
    Jeffrey A Kleim
    Brain Research Rehabilitation Center, Malcom Randall VA Hospital, 1601 SW Archer Road, Gainesville, Florida 32608, USA
    Nat Neurosci 9:735-7. 2006
  4. ncbi request reprint Functional organization of adult motor cortex is dependent upon continued protein synthesis
    Jeffrey A Kleim
    Canadian Centre for Behavioural Neuroscience, Department of Psychology and Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta T1K 3M4, Canada
    Neuron 40:167-76. 2003
  5. ncbi request reprint Motor learning-dependent synaptogenesis is localized to functionally reorganized motor cortex
    Jeffrey A Kleim
    Department of Psychology and Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, Canada, T1K 3M4
    Neurobiol Learn Mem 77:63-77. 2002
  6. ncbi request reprint Exercise induces angiogenesis but does not alter movement representations within rat motor cortex
    Jeffrey A Kleim
    Department of Psychology and Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Dr, Lethbridge, Alberta T1K 3M4, Canada
    Brain Res 934:1-6. 2002
  7. pmc Synapse formation is associated with memory storage in the cerebellum
    Jeffrey A Kleim
    Canadian Centre for Behavioural Neuroscience, Department of Psychology and Neuroscience, University of Lethbridge, Lethbridge, AB, Canada T1K 3M4
    Proc Natl Acad Sci U S A 99:13228-31. 2002
  8. ncbi request reprint Cortical synaptogenesis and motor map reorganization occur during late, but not early, phase of motor skill learning
    Jeffrey A Kleim
    Canadian Centre for Behavioural Neuroscience, Department of Psychology and Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada T1K 3M4
    J Neurosci 24:628-33. 2004
  9. ncbi request reprint Motor cortex stimulation enhances motor recovery and reduces peri-infarct dysfunction following ischemic insult
    Jeffrey A Kleim
    Department of Psychology and Neuroscience, Canadian Centre for Behavioural Neuroscience University of Lethbridge, 4401 University Dr, Lethbridge, Alberta, Canada T1K 3M4
    Neurol Res 25:789-93. 2003
  10. ncbi request reprint FGF-2-induced cell proliferation stimulates anatomical, neurophysiological and functional recovery from neonatal motor cortex injury
    Marie H Monfils
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, Canada
    Eur J Neurosci 24:739-49. 2006

Detail Information

Publications29

  1. ncbi request reprint III STEP: a basic scientist's perspective
    Jeffrey A Kleim
    Phys Ther 86:614-7. 2006
  2. ncbi request reprint Motor map expansion following repeated cortical and limbic seizures is related to synaptic potentiation
    G Campbell Teskey
    Behavioural Neuroscience Research Group, Department of Psychology, University of Calgary, Calgary, Alberta, Canada T2N 1N4
    Cereb Cortex 12:98-105. 2002
    ..Moreover, both the motor map and field potential enhancements were persistent in nature and could be driven from either cortical or limbic sites. The data have implications for human populations with epilepsy...
  3. ncbi request reprint BDNF val66met polymorphism is associated with modified experience-dependent plasticity in human motor cortex
    Jeffrey A Kleim
    Brain Research Rehabilitation Center, Malcom Randall VA Hospital, 1601 SW Archer Road, Gainesville, Florida 32608, USA
    Nat Neurosci 9:735-7. 2006
    ..The results suggest that BDNF is involved in mediating experience-dependent plasticity of human motor cortex...
  4. ncbi request reprint Functional organization of adult motor cortex is dependent upon continued protein synthesis
    Jeffrey A Kleim
    Canadian Centre for Behavioural Neuroscience, Department of Psychology and Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta T1K 3M4, Canada
    Neuron 40:167-76. 2003
    ..We propose that the circuitry of adult motor cortex is perpetually labile and requires continued protein synthesis in order to maintain its functional organization...
  5. ncbi request reprint Motor learning-dependent synaptogenesis is localized to functionally reorganized motor cortex
    Jeffrey A Kleim
    Department of Psychology and Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, Canada, T1K 3M4
    Neurobiol Learn Mem 77:63-77. 2002
    ....
  6. ncbi request reprint Exercise induces angiogenesis but does not alter movement representations within rat motor cortex
    Jeffrey A Kleim
    Department of Psychology and Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Dr, Lethbridge, Alberta T1K 3M4, Canada
    Brain Res 934:1-6. 2002
    ..These results demonstrate that increases in forelimb motor activity sufficient to induce cortical angiogenesis does not alter the topography of forelimb movement representations within forelimb motor cortex...
  7. pmc Synapse formation is associated with memory storage in the cerebellum
    Jeffrey A Kleim
    Canadian Centre for Behavioural Neuroscience, Department of Psychology and Neuroscience, University of Lethbridge, Lethbridge, AB, Canada T1K 3M4
    Proc Natl Acad Sci U S A 99:13228-31. 2002
    ..These results demonstrate that the modifications of specific neural pathways by means of synaptogenesis contributes to formation of a specific memory within the mammalian brain...
  8. ncbi request reprint Cortical synaptogenesis and motor map reorganization occur during late, but not early, phase of motor skill learning
    Jeffrey A Kleim
    Canadian Centre for Behavioural Neuroscience, Department of Psychology and Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada T1K 3M4
    J Neurosci 24:628-33. 2004
    ..We propose that motor map reorganization and synapse formation do not contribute to the initial acquisition of motor skills but represent the consolidation of motor skill that occurs during late stages of training...
  9. ncbi request reprint Motor cortex stimulation enhances motor recovery and reduces peri-infarct dysfunction following ischemic insult
    Jeffrey A Kleim
    Department of Psychology and Neuroscience, Canadian Centre for Behavioural Neuroscience University of Lethbridge, 4401 University Dr, Lethbridge, Alberta, Canada T1K 3M4
    Neurol Res 25:789-93. 2003
    ..The results demonstrate the behavioral and neurophysiological benefits of cortical stimulation in combination with rehabilitation for recovery from stroke...
  10. ncbi request reprint FGF-2-induced cell proliferation stimulates anatomical, neurophysiological and functional recovery from neonatal motor cortex injury
    Marie H Monfils
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, Canada
    Eur J Neurosci 24:739-49. 2006
    ....
  11. ncbi request reprint Limits on recovery in the corticospinal tract of the rat: partial lesions impair skilled reaching and the topographic representation of the forelimb in motor cortex
    Dionne M Piecharka
    Department of Psychology and Neuroscience, Canadian Centre for Behavioral Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, T1K 3M4, Canada
    Brain Res Bull 66:203-11. 2005
    ..The incomplete recovery, as measured both behaviorally and electrophysiologically, demonstrates that plasticity within the corticospinal system is limited even with lesions that permit substantial sparing of pyramidal tract fibers...
  12. ncbi request reprint Preserved ipsilateral-to-lesion motor map organization in the unilateral 6-OHDA-treated rat model of Parkinson's disease
    Gerlinde A Metz
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada, T1K 3M4, Canada
    Brain Res 1026:126-35. 2004
    ....
  13. ncbi request reprint Long-Evans and Sprague-Dawley rats have similar skilled reaching success and limb representations in motor cortex but different movements: some cautionary insights into the selection of rat strains for neurobiological motor research
    Ian Q Whishaw
    The Canadian Centre for Behavioural Neuroscience, The University of Lethbridge, Lethbridge, Alta, Canada T1K 3M4
    Behav Brain Res 145:221-32. 2003
    ....
  14. ncbi request reprint A novel phosphodiesterase type 4 inhibitor, HT-0712, enhances rehabilitation-dependent motor recovery and cortical reorganization after focal cortical ischemia
    Erin MacDonald
    Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada
    Neurorehabil Neural Repair 21:486-96. 2007
    ..Our results suggest that PDE4 inhibitors during motor rehabilitation facilitate behavioral recovery and cortical reorganization after ischemic insult to levels significantly greater than that observed with rehabilitation alone...
  15. ncbi request reprint Long-Evans rats have a larger cortical topographic representation of movement than Fischer-344 rats: a microstimulation study of motor cortex in naïve and skilled reaching-trained rats
    Penny M VandenBerg
    Department of Psychology and Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Alta, Lethbridge, Canada
    Brain Res Bull 59:197-203. 2002
    ..The results are discussed in relation to using strain differences as a way of examining the behavioral, the physiological, and the anatomical organization of the motor system...
  16. ncbi request reprint In search of the motor engram: motor map plasticity as a mechanism for encoding motor experience
    Marie H Monfils
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Alberta, Canada
    Neuroscientist 11:471-83. 2005
    ..Finally, the role of motor map plasticity in recovery of motor function after brain damage is discussed...
  17. doi request reprint Distributed versus focal cortical stimulation to enhance motor function and motor map plasticity in a rodent model of ischemia
    Jeffery A Boychuk
    University of Calgary, Alberta, Canada
    Neurorehabil Neural Repair 25:88-97. 2011
    ..This study examined the behavioral and neurophysiological effects of delivering CS/RT through a distributed versus focal arrangement of electrical contacts...
  18. ncbi request reprint Evidence for bilateral control of skilled movements: ipsilateral skilled forelimb reaching deficits and functional recovery in rats follow motor cortex and lateral frontal cortex lesions
    Claudia L R Gonzalez
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Dr, Lethbridge, AB T1K 3M4, Canada
    Eur J Neurosci 20:3442-52. 2004
    ....
  19. ncbi request reprint Motor enrichment and the induction of plasticity before or after brain injury
    Jeffrey A Kleim
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada
    Neurochem Res 28:1757-69. 2003
    ..However, it is possible that, in the chronic stages after brain injury, a regimen of exercise would reactivate mechanisms of plasticity and thus enhance rehabilitation targeting residual functional deficits...
  20. ncbi request reprint A quantitative comparison of synaptic density following perfusion versus immersion fixation in the rat cerebral cortex
    Marie H Monfils
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada, T1K 3M4
    Microsc Res Tech 67:300-4. 2005
    ..Our results suggest that, despite suboptimal qualitative results, fixation by immersion allows for adequate quantification of synapses...
  21. ncbi request reprint Long-term potentiation induces expanded movement representations and dendritic hypertrophy in layer V of rat sensorimotor neocortex
    Marie H Monfils
    Department of Psychology, University of Calgary, Calgary, Alberta, Canada T2N 1N4
    Cereb Cortex 14:586-93. 2004
    ..This study sheds light on the interaction between artificial models of learning, receptive field characteristics and dendritic morphology in the sensorimotor cortex...
  22. ncbi request reprint Learning-induced multiple synapse formation in rat cerebellar cortex
    Kara D Federmeier
    Department of Psychology, University of Illinois Urbana Champaign, Urbana, IL, USA
    Neurosci Lett 332:180-4. 2002
    ..The formation of multiple synapses provides an additional connection between a given parallel fiber and Purkinje cell, thereby enhancing particular pathways, and may constitute a fundamental mechanism of neural encoding...
  23. ncbi request reprint Systematic assessment of training-induced changes in corticospinal output to hand using frameless stereotaxic transcranial magnetic stimulation
    Jeffrey A Kleim
    Brain Rehabilitation Research Center, Malcom Randall VA Hospital, 1601 SW Archer Road, Gainesville, Florida 32608, USA
    Nat Protoc 2:1675-84. 2007
    ..The protocol allows for reliably and repeatedly detecting changes in corticospinal output to FDI muscle in response to brief periods of motor training...
  24. pmc Motor learning induces astrocytic hypertrophy in the cerebellar cortex
    Jeffrey A Kleim
    Department of Neuroscience, University of Florida College of Medicine, Gainesville, FL 32610, USA
    Behav Brain Res 178:244-9. 2007
    ..These findings demonstrate that learning triggers the hypertrophy of astrocytic processes and furthermore that, unlike learning-induced synaptogenesis, astrocytic growth is reduced in the absence of continued training...
  25. ncbi request reprint Motor training induces experience-specific patterns of plasticity across motor cortex and spinal cord
    DeAnna L Adkins
    Brain Rehabilitation Research Center, Malcom Randall Veterans Affairs Hospital, Gainesville, FL, USA
    J Appl Physiol 101:1776-82. 2006
    ..The consequences of such distributed, experience-specific plasticity for the encoding of motor experience by the motor system are discussed...
  26. ncbi request reprint A brain adaptation view of plasticity: is synaptic plasticity an overly limited concept?
    Aaron W Grossman
    Beckman Institute, Neuroscience Program, Medical Scholars Program, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Prog Brain Res 138:91-108. 2002
    ..Appreciation of this aspect of the brain's adaptive process may allow us to better understand the capacity of the brain to tailor a particular set of changes to the demands of the specific experiences that generated them...
  27. ncbi request reprint Induction of neocortical long-term depression results in smaller movement representations, fewer excitatory perforated synapses, and more inhibitory synapses
    G Campbell Teskey
    Behavioural Neuroscience Research Group, Department of Psychology and the Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada T2N 1N4
    Cereb Cortex 17:434-42. 2007
    ..This study sheds light on the interaction between an artificial model of learning, receptive field characteristics, and synaptic number in the sensorimotor cortex...
  28. ncbi request reprint Rat models of upper extremity impairment in stroke
    Jeffrey A Kleim
    Department of Neuroscience, McKnight Brain Institute, 100 South Newell Drive, University of Florida, Gainesville, FL 32610, USA
    ILAR J 48:374-84. 2007
    ..Finally, we outline general considerations for conducting research using rat models of stroke and the role that these models should play in guiding clinical trials...
  29. doi request reprint Principles of experience-dependent neural plasticity: implications for rehabilitation after brain damage
    Jeffrey A Kleim
    McKnight Brain Institute, University of Florida, Gainesville, and Brain Rehabilitation Research Center 151A, Malcom Randall VA Hospital, 1610 SW Archer Road, Gainesville, FL 32610, USA
    J Speech Lang Hear Res 51:S225-39. 2008
    ..This paper reviews 10 principles of experience-dependent neural plasticity and considerations in applying them to the damaged brain...