Research Topics
| Jeffrey A KleimSummaryAffiliation: University of Lethbridge Country: Canada Publications
| Collaborators
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Detail Information
Publications
Motor map expansion following repeated cortical and limbic seizures is related to synaptic potentiationG Campbell Teskey
Behavioural Neuroscience Research Group, Department of Psychology, University of Calgary, Calgary, Alberta, Canada T2N 1N4
Cereb Cortex 12:98-105. 2002..Moreover, both the motor map and field potential enhancements were persistent in nature and could be driven from either cortical or limbic sites. The data have implications for human populations with epilepsy...- III STEP: a basic scientist's perspectiveJeffrey A Kleim
Phys Ther 86:614-7. 2006 - BDNF val66met polymorphism is associated with modified experience-dependent plasticity in human motor cortexJeffrey A Kleim
Brain Research Rehabilitation Center, Malcom Randall VA Hospital, 1601 SW Archer Road, Gainesville, Florida 32608, USA
Nat Neurosci 9:735-7. 2006..The results suggest that BDNF is involved in mediating experience-dependent plasticity of human motor cortex... - Functional organization of adult motor cortex is dependent upon continued protein synthesisJeffrey A Kleim
Canadian Centre for Behavioural Neuroscience, Department of Psychology and Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta T1K 3M4, Canada
Neuron 40:167-76. 2003..We propose that the circuitry of adult motor cortex is perpetually labile and requires continued protein synthesis in order to maintain its functional organization... - Motor learning-dependent synaptogenesis is localized to functionally reorganized motor cortexJeffrey A Kleim
Department of Psychology and Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, Canada, T1K 3M4
Neurobiol Learn Mem 77:63-77. 2002.... - Exercise induces angiogenesis but does not alter movement representations within rat motor cortexJeffrey A Kleim
Department of Psychology and Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Dr, Lethbridge, Alberta T1K 3M4, Canada
Brain Res 934:1-6. 2002..These results demonstrate that increases in forelimb motor activity sufficient to induce cortical angiogenesis does not alter the topography of forelimb movement representations within forelimb motor cortex... 
Synapse formation is associated with memory storage in the cerebellumJeffrey A Kleim
Canadian Centre for Behavioural Neuroscience, Department of Psychology and Neuroscience, University of Lethbridge, Lethbridge, AB, Canada T1K 3M4
Proc Natl Acad Sci U S A 99:13228-31. 2002..These results demonstrate that the modifications of specific neural pathways by means of synaptogenesis contributes to formation of a specific memory within the mammalian brain...- Cortical synaptogenesis and motor map reorganization occur during late, but not early, phase of motor skill learningJeffrey A Kleim
Canadian Centre for Behavioural Neuroscience, Department of Psychology and Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada T1K 3M4
J Neurosci 24:628-33. 2004..We propose that motor map reorganization and synapse formation do not contribute to the initial acquisition of motor skills but represent the consolidation of motor skill that occurs during late stages of training... - Motor cortex stimulation enhances motor recovery and reduces peri-infarct dysfunction following ischemic insultJeffrey A Kleim
Department of Psychology and Neuroscience, Canadian Centre for Behavioural Neuroscience University of Lethbridge, 4401 University Dr, Lethbridge, Alberta, Canada T1K 3M4
Neurol Res 25:789-93. 2003..The results demonstrate the behavioral and neurophysiological benefits of cortical stimulation in combination with rehabilitation for recovery from stroke... - FGF-2-induced cell proliferation stimulates anatomical, neurophysiological and functional recovery from neonatal motor cortex injuryMarie H Monfils
Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, Canada
Eur J Neurosci 24:739-49. 2006.... - Limits on recovery in the corticospinal tract of the rat: partial lesions impair skilled reaching and the topographic representation of the forelimb in motor cortexDionne M Piecharka
Department of Psychology and Neuroscience, Canadian Centre for Behavioral Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, T1K 3M4, Canada
Brain Res Bull 66:203-11. 2005..The incomplete recovery, as measured both behaviorally and electrophysiologically, demonstrates that plasticity within the corticospinal system is limited even with lesions that permit substantial sparing of pyramidal tract fibers... - Preserved ipsilateral-to-lesion motor map organization in the unilateral 6-OHDA-treated rat model of Parkinson's diseaseGerlinde A Metz
Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada, T1K 3M4, Canada
Brain Res 1026:126-35. 2004.... - Long-Evans and Sprague-Dawley rats have similar skilled reaching success and limb representations in motor cortex but different movements: some cautionary insights into the selection of rat strains for neurobiological motor researchIan Q Whishaw
The Canadian Centre for Behavioural Neuroscience, The University of Lethbridge, Lethbridge, Alta, Canada T1K 3M4
Behav Brain Res 145:221-32. 2003.... - A novel phosphodiesterase type 4 inhibitor, HT-0712, enhances rehabilitation-dependent motor recovery and cortical reorganization after focal cortical ischemiaErin MacDonald
Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada
Neurorehabil Neural Repair 21:486-96. 2007..Our results suggest that PDE4 inhibitors during motor rehabilitation facilitate behavioral recovery and cortical reorganization after ischemic insult to levels significantly greater than that observed with rehabilitation alone... - Long-Evans rats have a larger cortical topographic representation of movement than Fischer-344 rats: a microstimulation study of motor cortex in naïve and skilled reaching-trained ratsPenny M VandenBerg
Department of Psychology and Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Alta, Lethbridge, Canada
Brain Res Bull 59:197-203. 2002..The results are discussed in relation to using strain differences as a way of examining the behavioral, the physiological, and the anatomical organization of the motor system... - In search of the motor engram: motor map plasticity as a mechanism for encoding motor experienceMarie-H Monfils
Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Alberta, Canada
Neuroscientist 11:471-83. 2005..Finally, the role of motor map plasticity in recovery of motor function after brain damage is discussed... 
Distributed versus focal cortical stimulation to enhance motor function and motor map plasticity in a rodent model of ischemiaJeffery A Boychuk
University of Calgary, Alberta, Canada
Neurorehabil Neural Repair 25:88-97. 2011..This study examined the behavioral and neurophysiological effects of delivering CS/RT through a distributed versus focal arrangement of electrical contacts...- Evidence for bilateral control of skilled movements: ipsilateral skilled forelimb reaching deficits and functional recovery in rats follow motor cortex and lateral frontal cortex lesionsClaudia L R Gonzalez
Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Dr, Lethbridge, AB T1K 3M4, Canada
Eur J Neurosci 20:3442-52. 2004.... - Motor enrichment and the induction of plasticity before or after brain injuryJeffrey A Kleim
Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada
Neurochem Res 28:1757-69. 2003..However, it is possible that, in the chronic stages after brain injury, a regimen of exercise would reactivate mechanisms of plasticity and thus enhance rehabilitation targeting residual functional deficits... - A quantitative comparison of synaptic density following perfusion versus immersion fixation in the rat cerebral cortexMarie H Monfils
Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada, T1K 3M4
Microsc Res Tech 67:300-4. 2005..Our results suggest that, despite suboptimal qualitative results, fixation by immersion allows for adequate quantification of synapses... - Long-term potentiation induces expanded movement representations and dendritic hypertrophy in layer V of rat sensorimotor neocortexMarie-H Monfils
Department of Psychology, University of Calgary, Calgary, Alberta, Canada T2N 1N4
Cereb Cortex 14:586-93. 2004..This study sheds light on the interaction between artificial models of learning, receptive field characteristics and dendritic morphology in the sensorimotor cortex... - Learning-induced multiple synapse formation in rat cerebellar cortexKara D Federmeier
Department of Psychology, University of Illinois Urbana-Champaign, Urbana, IL, USA
Neurosci Lett 332:180-4. 2002..The formation of multiple synapses provides an additional connection between a given parallel fiber and Purkinje cell, thereby enhancing particular pathways, and may constitute a fundamental mechanism of neural encoding... - Systematic assessment of training-induced changes in corticospinal output to hand using frameless stereotaxic transcranial magnetic stimulationJeffrey A Kleim
Brain Rehabilitation Research Center, Malcom Randall VA Hospital, 1601 SW Archer Road, Gainesville, Florida 32608, USA
Nat Protoc 2:1675-84. 2007..The protocol allows for reliably and repeatedly detecting changes in corticospinal output to FDI muscle in response to brief periods of motor training... - Motor learning induces astrocytic hypertrophy in the cerebellar cortexJeffrey A Kleim
Department of Neuroscience, University of Florida College of Medicine, Gainesville, FL 32610, USA
Behav Brain Res 178:244-9. 2007..These findings demonstrate that learning triggers the hypertrophy of astrocytic processes and furthermore that, unlike learning-induced synaptogenesis, astrocytic growth is reduced in the absence of continued training... - Motor training induces experience-specific patterns of plasticity across motor cortex and spinal cordDeAnna L Adkins
Brain Rehabilitation Research Center, Malcom Randall Veterans Affairs Hospital, Gainesville, FL, USA
J Appl Physiol 101:1776-82. 2006..The consequences of such distributed, experience-specific plasticity for the encoding of motor experience by the motor system are discussed... - A brain adaptation view of plasticity: is synaptic plasticity an overly limited concept?Aaron W Grossman
Beckman Institute, Neuroscience Program, Medical Scholars Program, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
Prog Brain Res 138:91-108. 2002..Appreciation of this aspect of the brain's adaptive process may allow us to better understand the capacity of the brain to tailor a particular set of changes to the demands of the specific experiences that generated them... - Induction of neocortical long-term depression results in smaller movement representations, fewer excitatory perforated synapses, and more inhibitory synapsesG Campbell Teskey
Behavioural Neuroscience Research Group, Department of Psychology and the Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada T2N 1N4
Cereb Cortex 17:434-42. 2007..This study sheds light on the interaction between an artificial model of learning, receptive field characteristics, and synaptic number in the sensorimotor cortex... - Rat models of upper extremity impairment in strokeJeffrey A Kleim
Department of Neuroscience, McKnight Brain Institute, 100 South Newell Drive, University of Florida, Gainesville, FL 32610, USA
ILAR J 48:374-84. 2007..Finally, we outline general considerations for conducting research using rat models of stroke and the role that these models should play in guiding clinical trials... - Principles of experience-dependent neural plasticity: implications for rehabilitation after brain damageJeffrey A Kleim
McKnight Brain Institute, University of Florida, Gainesville, and Brain Rehabilitation Research Center 151A, Malcom Randall VA Hospital, 1610 SW Archer Road, Gainesville, FL 32610, USA
J Speech Lang Hear Res 51:S225-39. 2008..This paper reviews 10 principles of experience-dependent neural plasticity and considerations in applying them to the damaged brain...