Christian Klausen

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. doi request reprint Cell motility and spreading are suppressed by HOXA4 in ovarian cancer cells: possible involvement of beta1 integrin
    Christian Klausen
    Department of Obstetrics and Gynaecology, University of British Columbia, 2H30 4490 Oak Street, B C Women s Hospital, Vancouver, B C V6H 3V5, Canada
    Mol Cancer Res 7:1425-37. 2009
  2. pmc Kisspeptin and GPR54 immunoreactivity in a cohort of 518 patients defines favourable prognosis and clear cell subtype in ovarian carcinoma
    Leah M Prentice
    Molecular Oncology and Breast Cancer Program, British Columbia Cancer Research Centre and Department of Pathology, University ofBritish Columbia, Vancouver, British Columbia, Canada
    BMC Med 5:33. 2007
  3. doi request reprint Hypoxia-inducible factor 1 alpha mediates epidermal growth factor-induced down-regulation of E-cadherin expression and cell invasion in human ovarian cancer cells
    Jung Chien Cheng
    Department of Obstetrics and Gynaecology, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada V5Z 4H4
    Cancer Lett 329:197-206. 2013
  4. doi request reprint BMP15 suppresses progesterone production by down-regulating StAR via ALK3 in human granulosa cells
    Hsun Ming Chang
    PhD, FCAHS, FRSC, Department of Obstetrics and Gynaecology, Child and Family Research Institute, University of British Columbia, Room 317, 950 West 28th Avenue, Vancouver, British Columbia, Canada, V5Z 4H4
    Mol Endocrinol 27:2093-104. 2013
  5. doi request reprint Hydrogen peroxide mediates EGF-induced down-regulation of E-cadherin expression via p38 MAPK and snail in human ovarian cancer cells
    Jung Chien Cheng
    Department of Obstetrics and Gynecology, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
    Mol Endocrinol 24:1569-80. 2010
  6. doi request reprint Growth differentiation factor 8 down-regulates pentraxin 3 in human granulosa cells
    Hsun Ming Chang
    Department of Obstetrics and Gynaecology, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada
    Mol Cell Endocrinol 404:82-90. 2015
  7. doi request reprint Recombinant BMP4 and BMP7 downregulate pentraxin 3 in human granulosa cells
    Hsun Ming Chang
    Department of Obstetrics and Gynaecology, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada V5Z 4H4
    J Clin Endocrinol Metab 100:E365-74. 2015
  8. doi request reprint Effects of recombinant activins on steroidogenesis in human granulosa-lutein cells
    Hsun Ming Chang
    Department of Obstetrics and Gynecology, Child and Family Research Institute, University of British Columbia, Vancouver, BC V5Z 4H4, Canada
    J Clin Endocrinol Metab 99:E1922-32. 2014
  9. doi request reprint Transforming growth factor-α induces human ovarian cancer cell invasion by down-regulating E-cadherin in a Snail-independent manner
    Xin Qiu
    Department of Obstetrics and Gynaecology, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada
    Biochem Biophys Res Commun 461:128-35. 2015
  10. pmc Overexpression of wild-type but not C134W mutant FOXL2 enhances GnRH-induced cell apoptosis by increasing GnRH receptor expression in human granulosa cell tumors
    Jung Chien Cheng
    Department of Obstetrics and Gynaecology, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
    PLoS ONE 8:e55099. 2013

Collaborators

Detail Information

Publications19

  1. doi request reprint Cell motility and spreading are suppressed by HOXA4 in ovarian cancer cells: possible involvement of beta1 integrin
    Christian Klausen
    Department of Obstetrics and Gynaecology, University of British Columbia, 2H30 4490 Oak Street, B C Women s Hospital, Vancouver, B C V6H 3V5, Canada
    Mol Cancer Res 7:1425-37. 2009
    ..These observations support the hypothesis that overexpression of HOXA4 in invasive ovarian tumors is a homeostatic, invasion-suppressive response...
  2. pmc Kisspeptin and GPR54 immunoreactivity in a cohort of 518 patients defines favourable prognosis and clear cell subtype in ovarian carcinoma
    Leah M Prentice
    Molecular Oncology and Breast Cancer Program, British Columbia Cancer Research Centre and Department of Pathology, University ofBritish Columbia, Vancouver, British Columbia, Canada
    BMC Med 5:33. 2007
    ..Here, for the first time, we associate the immunoreactivity of the kisspeptin/GPR54 ligand-receptor pair with favourable prognosis in a large cohort of ovarian carcinomas...
  3. doi request reprint Hypoxia-inducible factor 1 alpha mediates epidermal growth factor-induced down-regulation of E-cadherin expression and cell invasion in human ovarian cancer cells
    Jung Chien Cheng
    Department of Obstetrics and Gynaecology, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada V5Z 4H4
    Cancer Lett 329:197-206. 2013
    ..This study demonstrates an important role for HIF-1α in mediating the effects of EGF on Snail, Slug and E-cadherin expression as well as invasiveness in human ovarian cancer cells...
  4. doi request reprint BMP15 suppresses progesterone production by down-regulating StAR via ALK3 in human granulosa cells
    Hsun Ming Chang
    PhD, FCAHS, FRSC, Department of Obstetrics and Gynaecology, Child and Family Research Institute, University of British Columbia, Room 317, 950 West 28th Avenue, Vancouver, British Columbia, Canada, V5Z 4H4
    Mol Endocrinol 27:2093-104. 2013
    ..Our findings suggest that oocyte may play a critical role in the regulation of progesterone to prevent premature luteinization during the late stage of follicle development. ..
  5. doi request reprint Hydrogen peroxide mediates EGF-induced down-regulation of E-cadherin expression via p38 MAPK and snail in human ovarian cancer cells
    Jung Chien Cheng
    Department of Obstetrics and Gynecology, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
    Mol Endocrinol 24:1569-80. 2010
    ..This study demonstrates a novel mechanism in which EGF down-regulates E-cadherin expression through production of H(2)O(2), activation of p38 MAPK, and up-regulation of Snail in human ovarian cancer cells...
  6. doi request reprint Growth differentiation factor 8 down-regulates pentraxin 3 in human granulosa cells
    Hsun Ming Chang
    Department of Obstetrics and Gynaecology, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada
    Mol Cell Endocrinol 404:82-90. 2015
    ..These novel findings support a potential role for GDF8 in the regulation of follicular function, likely via autocrine effects on human granulosa cells. ..
  7. doi request reprint Recombinant BMP4 and BMP7 downregulate pentraxin 3 in human granulosa cells
    Hsun Ming Chang
    Department of Obstetrics and Gynaecology, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada V5Z 4H4
    J Clin Endocrinol Metab 100:E365-74. 2015
    ..Pentraxin 3 (PTX3) plays a critical role in the assembly of the cumulus oophorus extracellular matrix, which is essential for cumulus expansion during ovulation and may be modulated by BMP4 and BMP7...
  8. doi request reprint Effects of recombinant activins on steroidogenesis in human granulosa-lutein cells
    Hsun Ming Chang
    Department of Obstetrics and Gynecology, Child and Family Research Institute, University of British Columbia, Vancouver, BC V5Z 4H4, Canada
    J Clin Endocrinol Metab 99:E1922-32. 2014
    ..Although activins A (βAβA), B (βBβB), AB (βAβB), and AC (βAβC) have been demonstrated in the female reproductive system, little is known about their individual functions in the ovary...
  9. doi request reprint Transforming growth factor-α induces human ovarian cancer cell invasion by down-regulating E-cadherin in a Snail-independent manner
    Xin Qiu
    Department of Obstetrics and Gynaecology, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada
    Biochem Biophys Res Commun 461:128-35. 2015
    ..This study shows that TGF-α uses common and divergent molecular mediators to regulate E-cadherin expression and cell invasion. ..
  10. pmc Overexpression of wild-type but not C134W mutant FOXL2 enhances GnRH-induced cell apoptosis by increasing GnRH receptor expression in human granulosa cell tumors
    Jung Chien Cheng
    Department of Obstetrics and Gynaecology, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
    PLoS ONE 8:e55099. 2013
    ..These results suggest that the FOXL2 402C>G mutation may contribute to the development of human adult-type GCTs by reducing the expression of GnRH receptor, thus conferring resistance to GnRH-induced cell apoptosis...
  11. doi request reprint Expression and function of HOXA genes in normal and neoplastic ovarian epithelial cells
    Takayo Ota
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of British Columbia, 2H30 4490 Oak St, B C Women s Hospital, Vancouver, BC, Canada V6H 3V5
    Differentiation 77:162-71. 2009
    ..In summary, increased HOXA4 expression in ovarian cancer appears to constitute a tumor-suppressive, homeostatic response to aberrant cell behavior, and, in particular, to cell dispersion and migration...
  12. doi request reprint Growth differentiation factor 9 reverses activin A suppression of steroidogenic acute regulatory protein expression and progesterone production in human granulosa-lutein cells
    Feng Tao Shi
    Department of Obstetrics and Gynaecology, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
    J Clin Endocrinol Metab 95:E172-80. 2010
    ..We undertook this study to further evaluate GDF9 in this regard...
  13. doi request reprint Recombinant BMP4 and BMP7 increase activin A production by up-regulating inhibin βA subunit and furin expression in human granulosa-lutein cells
    Hsun Ming Chang
    Department of Obstetrics and Gynaecology, Child and Family Research Institute, University of British Columbia, Vancouver, Canada V5Z 4H4
    J Clin Endocrinol Metab 100:E375-86. 2015
    ..To date, there is limited information pertaining to the intracellular regulation, assembly, and secretion of endogenous activin A in human granulosa cells...
  14. doi request reprint Antimüllerian hormone inhibits follicle-stimulating hormone-induced adenylyl cyclase activation, aromatase expression, and estradiol production in human granulosa-lutein cells
    Hsun Ming Chang
    Department of Obstetrics and Gynaecology, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
    Fertil Steril 100:585-92.e1. 2013
    ....
  15. doi request reprint The human gonadotropin-inhibitory hormone ortholog RFamide-related peptide-3 suppresses gonadotropin-induced progesterone production in human granulosa cells
    Hajime Oishi
    Department of Obstetrics and Gynaecology, Child and Family Research Institute, University of British Columbia, 4490 Oak Street, Vancouver, British Columbia, Canada V6H 3V5
    Endocrinology 153:3435-45. 2012
    ..Thus, ovarian RFRP-3/GPR147 signaling could contribute to normal ovarian function...
  16. doi request reprint 37-kDa laminin receptor precursor mediates GnRH-II-induced MMP-2 expression and invasiveness in ovarian cancer cells
    Song Ling Poon
    Department of Obstetrics and Gynecology, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
    Mol Endocrinol 25:327-38. 2011
    ....
  17. doi request reprint Activin A, B, and AB increase human trophoblast cell invasion by up-regulating N-cadherin
    Yan Li
    Department of Obstetrics and Gynaecology, Child and Family Research Institute, University of British Columbia, Vancouver, BC V5Z 4H4, Canada
    J Clin Endocrinol Metab 99:E2216-25. 2014
    ..Moreover, whether the expression of mesenchymal adhesion molecule neural cadherin (N-cadherin) is essential for this proinvasive effect of activin has yet to be determined...
  18. doi request reprint AP-1 Transcription Factors c-FOS and c-JUN Mediate GnRH-Induced Cadherin-11 Expression and Trophoblast Cell Invasion
    Bo Peng
    Department of Obstetrics and Gynaecology B P, H Z, C K, P C K L, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada V5Z 4H4 and State Key Laboratory of Reproductive Biology L M, Y W, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, People s Republic of China
    Endocrinology 156:2269-77. 2015
    ..Our results suggest that GnRH induces the expression and phosphorylation of the AP-1 transcription factors c-FOS and c-JUN in trophoblast cells, which contributes to GnRH-induced elevation of cadherin-11 expression and cell invasion. ..
  19. pmc HOXA4 protein levels and localization in the aorta and in human abdominal aortic aneurysms
    Christian Klausen
    Department of Obstetrics and Gynaecology, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
    BMC Physiol 11:18. 2011
    ..which cannot be attributed to HOXA4. Our results highlight and briefly discuss the importance of careful antibody validation and selection for use in various applications...