Christian Klausen

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. doi request reprint Cell motility and spreading are suppressed by HOXA4 in ovarian cancer cells: possible involvement of beta1 integrin
    Christian Klausen
    Department of Obstetrics and Gynaecology, University of British Columbia, 2H30 4490 Oak Street, B C Women s Hospital, Vancouver, B C V6H 3V5, Canada
    Mol Cancer Res 7:1425-37. 2009
  2. pmc Kisspeptin and GPR54 immunoreactivity in a cohort of 518 patients defines favourable prognosis and clear cell subtype in ovarian carcinoma
    Leah M Prentice
    Molecular Oncology and Breast Cancer Program, British Columbia Cancer Research Centre and Department of Pathology, University ofBritish Columbia, Vancouver, British Columbia, Canada
    BMC Med 5:33. 2007
  3. doi request reprint Hypoxia-inducible factor 1 alpha mediates epidermal growth factor-induced down-regulation of E-cadherin expression and cell invasion in human ovarian cancer cells
    Jung Chien Cheng
    Department of Obstetrics and Gynaecology, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada V5Z 4H4
    Cancer Lett 329:197-206. 2013
  4. ncbi request reprint Hydrogen peroxide mediates EGF-induced down-regulation of E-cadherin expression via p38 MAPK and snail in human ovarian cancer cells
    Jung Chien Cheng
    Department of Obstetrics and Gynecology, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
    Mol Endocrinol 24:1569-80. 2010
  5. pmc Overexpression of wild-type but not C134W mutant FOXL2 enhances GnRH-induced cell apoptosis by increasing GnRH receptor expression in human granulosa cell tumors
    Jung Chien Cheng
    Department of Obstetrics and Gynaecology, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
    PLoS ONE 8:e55099. 2013
  6. doi request reprint Expression and function of HOXA genes in normal and neoplastic ovarian epithelial cells
    Takayo Ota
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of British Columbia, 2H30 4490 Oak St, B C Women s Hospital, Vancouver, BC, Canada V6H 3V5
    Differentiation 77:162-71. 2009
  7. doi request reprint Growth differentiation factor 9 reverses activin A suppression of steroidogenic acute regulatory protein expression and progesterone production in human granulosa-lutein cells
    Feng Tao Shi
    Department of Obstetrics and Gynaecology, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
    J Clin Endocrinol Metab 95:E172-80. 2010
  8. doi request reprint Antimüllerian hormone inhibits follicle-stimulating hormone-induced adenylyl cyclase activation, aromatase expression, and estradiol production in human granulosa-lutein cells
    Hsun Ming Chang
    Department of Obstetrics and Gynaecology, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
    Fertil Steril 100:585-92.e1. 2013
  9. doi request reprint BMP15 suppresses progesterone production by down-regulating StAR via ALK3 in human granulosa cells
    Hsun Ming Chang
    PhD, FCAHS, FRSC, Department of Obstetrics and Gynaecology, Child and Family Research Institute, University of British Columbia, Room 317, 950 West 28th Avenue, Vancouver, British Columbia, Canada, V5Z 4H4
    Mol Endocrinol 27:2093-104. 2013
  10. doi request reprint The human gonadotropin-inhibitory hormone ortholog RFamide-related peptide-3 suppresses gonadotropin-induced progesterone production in human granulosa cells
    Hajime Oishi
    Department of Obstetrics and Gynaecology, Child and Family Research Institute, University of British Columbia, 4490 Oak Street, Vancouver, British Columbia, Canada V6H 3V5
    Endocrinology 153:3435-45. 2012

Collaborators

Detail Information

Publications12

  1. doi request reprint Cell motility and spreading are suppressed by HOXA4 in ovarian cancer cells: possible involvement of beta1 integrin
    Christian Klausen
    Department of Obstetrics and Gynaecology, University of British Columbia, 2H30 4490 Oak Street, B C Women s Hospital, Vancouver, B C V6H 3V5, Canada
    Mol Cancer Res 7:1425-37. 2009
    ..These observations support the hypothesis that overexpression of HOXA4 in invasive ovarian tumors is a homeostatic, invasion-suppressive response...
  2. pmc Kisspeptin and GPR54 immunoreactivity in a cohort of 518 patients defines favourable prognosis and clear cell subtype in ovarian carcinoma
    Leah M Prentice
    Molecular Oncology and Breast Cancer Program, British Columbia Cancer Research Centre and Department of Pathology, University ofBritish Columbia, Vancouver, British Columbia, Canada
    BMC Med 5:33. 2007
    ..Here, for the first time, we associate the immunoreactivity of the kisspeptin/GPR54 ligand-receptor pair with favourable prognosis in a large cohort of ovarian carcinomas...
  3. doi request reprint Hypoxia-inducible factor 1 alpha mediates epidermal growth factor-induced down-regulation of E-cadherin expression and cell invasion in human ovarian cancer cells
    Jung Chien Cheng
    Department of Obstetrics and Gynaecology, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada V5Z 4H4
    Cancer Lett 329:197-206. 2013
    ..This study demonstrates an important role for HIF-1α in mediating the effects of EGF on Snail, Slug and E-cadherin expression as well as invasiveness in human ovarian cancer cells...
  4. ncbi request reprint Hydrogen peroxide mediates EGF-induced down-regulation of E-cadherin expression via p38 MAPK and snail in human ovarian cancer cells
    Jung Chien Cheng
    Department of Obstetrics and Gynecology, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
    Mol Endocrinol 24:1569-80. 2010
    ..This study demonstrates a novel mechanism in which EGF down-regulates E-cadherin expression through production of H(2)O(2), activation of p38 MAPK, and up-regulation of Snail in human ovarian cancer cells...
  5. pmc Overexpression of wild-type but not C134W mutant FOXL2 enhances GnRH-induced cell apoptosis by increasing GnRH receptor expression in human granulosa cell tumors
    Jung Chien Cheng
    Department of Obstetrics and Gynaecology, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
    PLoS ONE 8:e55099. 2013
    ..These results suggest that the FOXL2 402C>G mutation may contribute to the development of human adult-type GCTs by reducing the expression of GnRH receptor, thus conferring resistance to GnRH-induced cell apoptosis...
  6. doi request reprint Expression and function of HOXA genes in normal and neoplastic ovarian epithelial cells
    Takayo Ota
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of British Columbia, 2H30 4490 Oak St, B C Women s Hospital, Vancouver, BC, Canada V6H 3V5
    Differentiation 77:162-71. 2009
    ..In summary, increased HOXA4 expression in ovarian cancer appears to constitute a tumor-suppressive, homeostatic response to aberrant cell behavior, and, in particular, to cell dispersion and migration...
  7. doi request reprint Growth differentiation factor 9 reverses activin A suppression of steroidogenic acute regulatory protein expression and progesterone production in human granulosa-lutein cells
    Feng Tao Shi
    Department of Obstetrics and Gynaecology, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
    J Clin Endocrinol Metab 95:E172-80. 2010
    ..We undertook this study to further evaluate GDF9 in this regard...
  8. doi request reprint Antimüllerian hormone inhibits follicle-stimulating hormone-induced adenylyl cyclase activation, aromatase expression, and estradiol production in human granulosa-lutein cells
    Hsun Ming Chang
    Department of Obstetrics and Gynaecology, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
    Fertil Steril 100:585-92.e1. 2013
    ....
  9. doi request reprint BMP15 suppresses progesterone production by down-regulating StAR via ALK3 in human granulosa cells
    Hsun Ming Chang
    PhD, FCAHS, FRSC, Department of Obstetrics and Gynaecology, Child and Family Research Institute, University of British Columbia, Room 317, 950 West 28th Avenue, Vancouver, British Columbia, Canada, V5Z 4H4
    Mol Endocrinol 27:2093-104. 2013
    ..Our findings suggest that oocyte may play a critical role in the regulation of progesterone to prevent premature luteinization during the late stage of follicle development. ..
  10. doi request reprint The human gonadotropin-inhibitory hormone ortholog RFamide-related peptide-3 suppresses gonadotropin-induced progesterone production in human granulosa cells
    Hajime Oishi
    Department of Obstetrics and Gynaecology, Child and Family Research Institute, University of British Columbia, 4490 Oak Street, Vancouver, British Columbia, Canada V6H 3V5
    Endocrinology 153:3435-45. 2012
    ..Thus, ovarian RFRP-3/GPR147 signaling could contribute to normal ovarian function...
  11. doi request reprint 37-kDa laminin receptor precursor mediates GnRH-II-induced MMP-2 expression and invasiveness in ovarian cancer cells
    Song Ling Poon
    Department of Obstetrics and Gynecology, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
    Mol Endocrinol 25:327-38. 2011
    ....
  12. pmc HOXA4 protein levels and localization in the aorta and in human abdominal aortic aneurysms
    Christian Klausen
    Department of Obstetrics and Gynaecology, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
    BMC Physiol 11:18. 2011
    ..which cannot be attributed to HOXA4. Our results highlight and briefly discuss the importance of careful antibody validation and selection for use in various applications...