T P Klassen

Summary

Affiliation: University of Alberta
Country: Canada

Publications

  1. ncbi request reprint Abstracts of randomized controlled trials presented at the society for pediatric research meeting: an example of publication bias
    Terry P Klassen
    Department of Pediatrics, University of Alberta, 2C3 67 Walter C Mackenzie Centre, Edmonton, Alberta, Canada T6G 2B7
    Arch Pediatr Adolesc Med 156:474-9. 2002
  2. ncbi request reprint Variation in utilization of computed tomography scanning for the investigation of minor head trauma in children: a Canadian experience
    T P Klassen
    Department of Pediatrics, University of Alberta, Health Sciences Centre, Edmonton, Canada
    Acad Emerg Med 7:739-44. 2000
  3. pmc Risk factors for methamphetamine use in youth: a systematic review
    Kelly Russell
    Department of Pediatrics, University of Alberta, Edmonton, Canada
    BMC Pediatr 8:48. 2008
  4. pmc Storytelling as a communication tool for health consumers: development of an intervention for parents of children with croup. Stories to communicate health information
    Lisa Hartling
    Alberta Research Centre for Health Evidence, Department of Pediatrics, University of Alberta, Edmonton, Canada
    BMC Pediatr 10:64. 2010
  5. pmc A descriptive analysis of child-relevant systematic reviews in the Cochrane Database of Systematic Reviews
    Simon Bow
    Alberta Research Centre for Health Evidence, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    BMC Pediatr 10:34. 2010
  6. pmc Children in reviews: methodological issues in child-relevant evidence syntheses
    Kristie Cramer
    Alberta Research Centre for Child Health Evidence, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    BMC Pediatr 5:38. 2005
  7. pmc Can electronic search engines optimize screening of search results in systematic reviews: an empirical study
    Margaret Sampson
    Chalmers Research Group, Children s Hospital of Eastern Ontario Research Institute, Ottawa, Canada
    BMC Med Res Methodol 6:7. 2006
  8. pmc Which resources should be used to identify RCT/CCTs for systematic reviews: a systematic review
    Ellen T Crumley
    HealthInfo and Searching Practice Inc, Edmonton, Canada
    BMC Med Res Methodol 5:24. 2005
  9. pmc An alternative to the hand searching gold standard: validating methodological search filters using relative recall
    Margaret Sampson
    Chalmers Research Group, Children s Hospital of Eastern Ontario Research Institute, Canada
    BMC Med Res Methodol 6:33. 2006
  10. pmc A randomized, placebo-controlled trial of prednisone in early Henoch Schönlein Purpura [ISRCTN85109383]
    Adam M Huber
    IWK Health Centre and Dalhousie University, Halifax, Nova Scotia, Canada
    BMC Med 2:7. 2004

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Abstracts of randomized controlled trials presented at the society for pediatric research meeting: an example of publication bias
    Terry P Klassen
    Department of Pediatrics, University of Alberta, 2C3 67 Walter C Mackenzie Centre, Edmonton, Alberta, Canada T6G 2B7
    Arch Pediatr Adolesc Med 156:474-9. 2002
    ..The increased interest in meta-analyses has highlighted the need to identify the totality of evidence when addressing treatment questions...
  2. ncbi request reprint Variation in utilization of computed tomography scanning for the investigation of minor head trauma in children: a Canadian experience
    T P Klassen
    Department of Pediatrics, University of Alberta, Health Sciences Centre, Edmonton, Canada
    Acad Emerg Med 7:739-44. 2000
    ....
  3. pmc Risk factors for methamphetamine use in youth: a systematic review
    Kelly Russell
    Department of Pediatrics, University of Alberta, Edmonton, Canada
    BMC Pediatr 8:48. 2008
    ..Results were presented separately by comparison group: low-risk (no previous drug abuse) and high-risk children (reported previous drug abuse or were recruited from a juvenile detention center)...
  4. pmc Storytelling as a communication tool for health consumers: development of an intervention for parents of children with croup. Stories to communicate health information
    Lisa Hartling
    Alberta Research Centre for Health Evidence, Department of Pediatrics, University of Alberta, Edmonton, Canada
    BMC Pediatr 10:64. 2010
    ..The objective of this paper is to describe the development of a story-based intervention for delivery of health evidence to parents of children with croup for use in a randomized controlled trial...
  5. pmc A descriptive analysis of child-relevant systematic reviews in the Cochrane Database of Systematic Reviews
    Simon Bow
    Alberta Research Centre for Health Evidence, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    BMC Pediatr 10:34. 2010
    ..The objective of this study was to describe child-relevant SRs from the Cochrane Database of Systematic Reviews (CDSR, Issue 2, 2009)...
  6. pmc Children in reviews: methodological issues in child-relevant evidence syntheses
    Kristie Cramer
    Alberta Research Centre for Child Health Evidence, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    BMC Pediatr 5:38. 2005
    ....
  7. pmc Can electronic search engines optimize screening of search results in systematic reviews: an empirical study
    Margaret Sampson
    Chalmers Research Group, Children s Hospital of Eastern Ontario Research Institute, Ottawa, Canada
    BMC Med Res Methodol 6:7. 2006
    ..Our objective is to test the ability of an Ultraseek search engine to rank MEDLINE records of the included studies of Cochrane reviews within the top half of all the records retrieved by the Boolean MEDLINE search used by the reviewers...
  8. pmc Which resources should be used to identify RCT/CCTs for systematic reviews: a systematic review
    Ellen T Crumley
    HealthInfo and Searching Practice Inc, Edmonton, Canada
    BMC Med Res Methodol 5:24. 2005
    ..This systematic review was conducted in order to assess the value of different resources to identify trials for inclusion in systematic reviews...
  9. pmc An alternative to the hand searching gold standard: validating methodological search filters using relative recall
    Margaret Sampson
    Chalmers Research Group, Children s Hospital of Eastern Ontario Research Institute, Canada
    BMC Med Res Methodol 6:33. 2006
    ..We demonstrate the feasibility of using relative recall of included studies from multiple systematic reviews to validate methodological search filters as an alternative to validation against a gold standard formed through hand searching...
  10. pmc A randomized, placebo-controlled trial of prednisone in early Henoch Schönlein Purpura [ISRCTN85109383]
    Adam M Huber
    IWK Health Centre and Dalhousie University, Halifax, Nova Scotia, Canada
    BMC Med 2:7. 2004
    ..The goal of this study was to investigate whether early corticosteroid administration could reduce the rate of renal or gastrointestinal complications in children with HSP...
  11. pmc Oral rehydration versus intravenous therapy for treating dehydration due to gastroenteritis in children: a meta-analysis of randomised controlled trials
    Steven Bellemare
    Alberta Research Centre for Child Health Evidence, Department of Pediatrics, University of Alberta, 2C3, 00 WMC, Edmonton, Alberta, Canada, T6G 2R7
    BMC Med 2:11. 2004
    ..We conducted a systematic review of randomised controlled trials (RCTs) to compare ORT and intravenous therapy (IVT) for the treatment of dehydration secondary to acute gastroenteritis in children...
  12. pmc A systematic review of intravenous gamma globulin for therapy of acute myocarditis
    Joan L Robinson
    Department of Pediatrics, Stollery Children s Hospital and University of Alberta, Edmonton, Alberta, Canada
    BMC Cardiovasc Disord 5:12. 2005
    ..Intravenous gamma globulin (IVGG) is commonly used in the management of acute myocarditis. The objective of this study was to systematically review the literature evaluating this practice...
  13. pmc Acyclovir for treating varicella in otherwise healthy children and adolescents: a systematic review of randomised controlled trials
    Terry P Klassen
    Alberta Research Center for Child Health Evidence, Department of Pediatrics, University of Alberta, 2C3, 00 WMC, Edmonton, Alberta, T6G 2R7, Canada
    BMC Pediatr 2:9. 2002
    ..We conducted a systematic review of randomised controlled trials that evaluated acyclovir for the treatment of chickenpox in otherwise healthy children...
  14. pmc Long term effects of a home visit to prevent childhood injury: three year follow up of a randomized trial
    W J King
    Department of Pediatrics, Children s Hospital of Eastern Ontario Research Institute, University of Ottawa, Ontario K1H 8L1, Canada
    Inj Prev 11:106-9. 2005
    ..To assess the long term effect of a home safety visit on the rate of home injury...
  15. ncbi request reprint Nebulized budesonide and oral dexamethasone for treatment of croup: a randomized controlled trial
    T P Klassen
    Department of Pediatrics, University of Ottawa, Ontario, Canada
    JAMA 279:1629-32. 1998
    ..The effectiveness of glucocorticoids for patients with croup is well established but it remains uncertain which glucocorticoid regimen is most effective...
  16. ncbi request reprint A randomized, clinical trial comparing butylcyanoacrylate with octylcyanoacrylate in the management of selected pediatric facial lacerations
    M H Osmond
    Department of Pediatrics, University of Ottawa, Ontario, Canada
    Acad Emerg Med 6:171-7. 1999
    ..To compare two tissue adhesives, butylcyanoacrylate and octylcyanoacrylate, in the treatment of small (<4 cm) superficial linear traumatic facial lacerations in children...
  17. ncbi request reprint Validation of the Ottawa Ankle Rules in children with ankle injuries
    A C Plint
    Department of Pediatrics, Children s Hospital of Eastern Ontario, University of Ottawa, Canada
    Acad Emerg Med 6:1005-9. 1999
    ..The objectives of this study were to determine the sensitivity and specificity of the OAR in children and to determine the potential change in x-ray utilization...
  18. doi request reprint StaR Child Health: developing evidence-based guidance for the design, conduct, and reporting of pediatric trials
    L Hartling
    Alberta Research Centre for Health Evidence, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    Clin Pharmacol Ther 90:727-31. 2011
    ..Through a systematic "knowledge to action" plan, StaR Child Health will make efforts to improve and expand the evidence base for child health across the world...
  19. pmc Epidemiology of electrical and lightning related deaths and injuries among Canadian children and youth
    B H Nguyen
    Division of Emergency Medicine, Department of Pediatrics, Hopital Ste Justine, Universite de Montreal, Montreal, Quebec, Canada
    Inj Prev 10:122-4. 2004
    ....
  20. pmc Effects of exercise on breast cancer patients and survivors: a systematic review and meta-analysis
    Margaret L McNeely
    Department of Behavioural Medicine, Faculty of Physical Education, University of Alberta, Edmonton, Alta
    CMAJ 175:34-41. 2006
    ..We sought to summarize the available evidence concerning the effects of exercise on breast cancer patients and survivors...
  21. ncbi request reprint Single data extraction generated more errors than double data extraction in systematic reviews
    Nina Buscemi
    Department of Pediatrics, University of Alberta Capital Health Evidence Based Practice Centre, Edmonton, Alberta T6G 2J3, Canada
    J Clin Epidemiol 59:697-703. 2006
    ..To conduct a pilot study to compare the frequency of errors that accompany single vs. double data extraction, compare the estimate of treatment effect derived from these methods, and compare the time requirements for these methods...
  22. pmc Efficacy and safety of exogenous melatonin for secondary sleep disorders and sleep disorders accompanying sleep restriction: meta-analysis
    Nina Buscemi
    University of Alberta Capital Health Evidence Based Practice Centre, Department of Pediatrics, University of Alberta, Edmonton, AB, Canada T6G 2J3
    BMJ 332:385-93. 2006
    ..To conduct a systematic review of the efficacy and safety of exogenous melatonin in managing secondary sleep disorders and sleep disorders accompanying sleep restriction, such as jet lag and shiftwork disorder...
  23. ncbi request reprint A systematic review identifies a lack of standardization in methods for handling missing variance data
    Natasha Wiebe
    Department of Medicine, Division of Nephrology, University of Alberta, Rm 4048, Research Transition Facility, 8308 114 Street, Edmonton, Alberta, Canada T6G 2E1
    J Clin Epidemiol 59:342-53. 2006
    ..To describe and critically appraise available methods for handling missing variance data in meta-analysis (MA)...
  24. pmc The efficacy and safety of exogenous melatonin for primary sleep disorders. A meta-analysis
    Nina Buscemi
    Capital Health Evidence based Practice Centre, Department of Pediatrics, University of Alberta, Edmonton, AB, Canada
    J Gen Intern Med 20:1151-8. 2005
    ..Exogenous melatonin has been increasingly used in the management of sleep disorders...
  25. ncbi request reprint The influence of display and statistical factors on the interpretation of metaanalysis results by physicians
    Parminder S Raina
    Department of Clinical Epidemiology and Biostatistics, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Med Care 43:1242-9. 2005
    ..The objective of this study was to determine the extent to which various factors affect the interpretation of metaanalytic results by physicians...
  26. ncbi request reprint Factors influencing the publication of randomized controlled trials in child health research
    Lisa Hartling
    Alberta Research Centre for Child Health Evidence, Department of Pediatrics, University of Alberta, Edmonton, Canada
    Arch Pediatr Adolesc Med 158:983-7. 2004
    ..Publication bias threatens the validity of clinical decisions. The root causes are relatively unknown, and there is limited investigation in child research literature...
  27. ncbi request reprint Language of publication restrictions in systematic reviews gave different results depending on whether the intervention was conventional or complementary
    Ba Pham
    Biomedical Data Sciences, GlaxoSmithKline, Toronto, Ontario, Canada
    J Clin Epidemiol 58:769-76. 2005
    ....
  28. ncbi request reprint Systematic reviews involving complementary and alternative medicine interventions had higher quality of reporting than conventional medicine reviews
    Margaret L Lawson
    Department of Pediatrics, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
    J Clin Epidemiol 58:777-84. 2005
    ....
  29. ncbi request reprint For randomized controlled trials, the quality of reports of complementary and alternative medicine was as good as reports of conventional medicine
    Terry P Klassen
    Department of Pediatrics, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada
    J Clin Epidemiol 58:763-8. 2005
    ....
  30. ncbi request reprint Should meta-analysts search Embase in addition to Medline?
    Margaret Sampson
    Chalmers Research Group, Children s Hospital of Eastern Ontario Research Institute, 401 Smyth Road, Ottawa, ON K1H 8L1, Canada
    J Clin Epidemiol 56:943-55. 2003
    ..88-0.99). Searching Medline but not Embase risks biasing a meta-analysis by finding studies that show larger estimates, but their prevalence seems low enough that the risk may be slight, provided the rest of the search is comprehensive...
  31. ncbi request reprint Challenges in systematic reviews of therapeutic devices and procedures
    Lisa Hartling
    Capital Health Evidence based Practice Center, University of Alberta, Edmonton, Canada
    Ann Intern Med 142:1100-11. 2005
    ....
  32. ncbi request reprint A systematic review of interventions to prevent childhood farm injuries
    Lisa Hartling
    Alberta Research Centre for Child Health Evidence, Department of Pediatrics, University of Alberta, Room 9424, 11402 University Ave, Edmonton, Alberta, Canada T6J 2G3
    Pediatrics 114:e483-96. 2004
    ..A specific focus was the effectiveness of the North American Guidelines for Children's Agricultural Tasks...
  33. ncbi request reprint A meta-analysis of randomized controlled trials evaluating the efficacy of epinephrine for the treatment of acute viral bronchiolitis
    Lisa Hartling
    Alberta Research Center for Child Health Evidence, Department of Pediatrics, University of Alberta, Edmonton, USA
    Arch Pediatr Adolesc Med 157:957-64. 2003
    ..Controversy exists surrounding the use of bronchodilators for bronchiolitis. Epinephrine hydrochloride is being used with increasing frequency in this group; however, its efficacy has not been systematically reviewed...
  34. doi request reprint Usefulness of systematic review search strategies in finding child health systematic reviews in MEDLINE
    Nicole Boluyt
    Center for Pediatric Clinical Epidemiology, Room H3 145, Emma Children s Hospital, Academic Medical Centre, PO Box 22700, 1100 DD Amsterdam, The Netherlands
    Arch Pediatr Adolesc Med 162:111-6. 2008
    ..To determine the sensitivity and precision of existing search strategies for retrieving child health systematic reviews in MEDLINE using PubMed...
  35. ncbi request reprint Strangulation with intravenous tubing: a previously undescribed adverse advent in children
    Daniel Garros
    Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    Pediatrics 111:e732-4. 2003
    ....
  36. ncbi request reprint Tissue adhesives for traumatic lacerations: a systematic review of randomized controlled trials
    Ken J Farion
    Department of Pediatrics, University of Ottawa, Children s Hospital of Eastern Ontario, Ottawa, Canada
    Acad Emerg Med 10:110-8. 2003
    ..To summarize the best available evidence for the effect of tissue adhesives (TAs) in managing traumatic lacerations in children and adults...
  37. pmc The efficacy and safety of drug treatments for chronic insomnia in adults: a meta-analysis of RCTs
    Nina Buscemi
    University of Alberta Capital Health Evidence Based Practice Centre, Department of Pediatrics, University of Alberta, Alberta, Canada
    J Gen Intern Med 22:1335-50. 2007
    ..Hypnotics have a role in the management of acute insomnia; however, the efficacy and safety of pharmacological interventions in the management of chronic insomnia is unclear...
  38. pmc Treatment in the pediatric emergency department is evidence based: a retrospective analysis
    Kellie L Waters
    Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    BMC Pediatr 6:26. 2006
    ..Further, we wished to ascertain what percentage of evidence for treatment provided in the PED comes from pediatric studies...
  39. ncbi request reprint A randomized controlled trial of mist in the acute treatment of moderate croup
    Gina M Neto
    Department of Pediatrics, University of Ottawa, Ottawa, Ontario, Canada
    Acad Emerg Med 9:873-9. 2002
    ..To determine whether the use of mist improves clinical symptoms in children presenting to the emergency department (ED) with moderate croup...
  40. ncbi request reprint Practice variation among pediatric emergency departments in the treatment of bronchiolitis
    Amy C Plint
    Department of Pediatrics, University of Ottawa, 401 Smyth Avenue, Ottawa, Ontario, Canada K1H 8L1
    Acad Emerg Med 11:353-60. 2004
    ....
  41. ncbi request reprint A randomized trial of a single dose of oral dexamethasone for mild croup
    Candice L Bjornson
    Department of Pediatrics, University of Calgary, Calgary, Alta, Canada
    N Engl J Med 351:1306-13. 2004
    ..However, most children with croup have mild symptoms, and it is unknown whether they would derive the same degree of benefit from dexamethasone treatment as children with more severe disease...
  42. pmc A randomized, double-blind, placebo-controlled noninferiority trial of amoxicillin for clinically diagnosed acute otitis media in children 6 months to 5 years of age
    Nicole Le Saux
    Department of Pediatrics, Children s Hospital of Eastern Ontario, Ottawa, Ont
    CMAJ 172:335-41. 2005
    ..In this double-blind noninferiority trial, we compared clinical improvement rates at 14 days for children (6 months to 5 years of age) with acute otitis media who were randomly assigned to receive amoxicillin or placebo...
  43. pmc Effectiveness of a home-based balance-training program in reducing sports-related injuries among healthy adolescents: a cluster randomized controlled trial
    Carolyn A Emery
    Sport Medicine Centre, Faculty of Kinesiology, University of Calgary, Calgary, Alta
    CMAJ 172:749-54. 2005
    ..We studied the effectiveness of a home-based balance-training program using a wobble board in improving static and dynamic balance and reducing sports-related injuries among healthy adolescents...
  44. ncbi request reprint Publication bias of randomized controlled trials in emergency medicine
    Maria B Ospina
    University of Alberta Evidence Based Practice Centre, Department of Emergency Medicine, University of Alberta, Edmonton, Alberta, Canada
    Acad Emerg Med 13:102-8. 2006
    ..The impact of positive-outcome bias, time-lag bias, and gray literature bias also was assessed...
  45. ncbi request reprint Bridging the gap between clinical research and knowledge translation in pediatric emergency medicine
    Lisa Hartling
    Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    Acad Emerg Med 14:968-77. 2007
    ....