James B Kirkland

Summary

Affiliation: University of Guelph
Country: Canada

Publications

  1. doi request reprint Niacin status impacts chromatin structure
    James B Kirkland
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    J Nutr 139:2397-401. 2009
  2. doi request reprint Niacin requirements for genomic stability
    James B Kirkland
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Mutat Res 733:14-20. 2012
  3. ncbi request reprint Niacin status, NAD distribution and ADP-ribose metabolism
    James B Kirkland
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Curr Pharm Des 15:3-11. 2009
  4. doi request reprint Niacin status and treatment-related leukemogenesis
    James B Kirkland
    University of Guelph, Guelph, Ontario, Canada, N1G 2W1
    Mol Cancer Ther 8:725-32. 2009
  5. doi request reprint Poly ADP-ribose polymerase-1 and health
    James B Kirkland
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    Exp Biol Med (Maywood) 235:561-8. 2010
  6. doi request reprint Niacin status and genomic instability in bone marrow cells; mechanisms favoring the progression of leukemogenesis
    James B Kirkland
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada, N1G 2W1
    Subcell Biochem 56:21-36. 2012
  7. ncbi request reprint Pharmacological intakes of niacin increase bone marrow poly(ADP-ribose) and the latency of ethylnitrosourea-induced carcinogenesis in rats
    Ann C Boyonoski
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, ON, Canada N1G 2W1
    J Nutr 132:115-20. 2002
  8. ncbi request reprint Chronic DNA damage and niacin deficiency enhance cell injury and cause unusual interactions in NAD and poly(ADP-ribose) metabolism in rat bone marrow
    Jennifer C Spronck
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Nutr Cancer 45:124-31. 2003
  9. doi request reprint Niacin supplementation decreases the incidence of alkylation-induced nonlymphocytic leukemia in Long-Evans rats
    Anne Pascale Bartleman
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    Nutr Cancer 60:251-8. 2008
  10. ncbi request reprint Niacin deficiency alters p53 expression and impairs etoposide-induced cell cycle arrest and apoptosis in rat bone marrow cells
    Jennifer C Spronck
    Department of Human Biology and Nutritional Sciences, University of Guelph, Ontario, Canada
    Nutr Cancer 57:88-99. 2007

Collaborators

Detail Information

Publications21

  1. doi request reprint Niacin status impacts chromatin structure
    James B Kirkland
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    J Nutr 139:2397-401. 2009
    ..These reactions produce a variety of localized effects in chromatin structure, and altered function in response to changes in niacin status may have dramatic effects on genomic stability, cell division and differentiation, and apoptosis...
  2. doi request reprint Niacin requirements for genomic stability
    James B Kirkland
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Mutat Res 733:14-20. 2012
    ..With exposure to stressors, like chemotherapy or excess sunlight, suraphysiological doses of niacin may be beneficial...
  3. ncbi request reprint Niacin status, NAD distribution and ADP-ribose metabolism
    James B Kirkland
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Curr Pharm Des 15:3-11. 2009
    ..This article will explore what is known and yet to be learned about the response of tissues, cells and subcellular compartments to excessive and limiting supplies of niacin, and will discuss the etiology of the resulting pathologies...
  4. doi request reprint Niacin status and treatment-related leukemogenesis
    James B Kirkland
    University of Guelph, Guelph, Ontario, Canada, N1G 2W1
    Mol Cancer Ther 8:725-32. 2009
    ....
  5. doi request reprint Poly ADP-ribose polymerase-1 and health
    James B Kirkland
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    Exp Biol Med (Maywood) 235:561-8. 2010
    ..Promising new PARP-1 inhibitors may display interactions with dietary niacin status and may have long-term deleterious effects on genomic stability, but may be extremely valuable for the treatment of acute inflammatory conditions...
  6. doi request reprint Niacin status and genomic instability in bone marrow cells; mechanisms favoring the progression of leukemogenesis
    James B Kirkland
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada, N1G 2W1
    Subcell Biochem 56:21-36. 2012
    ....
  7. ncbi request reprint Pharmacological intakes of niacin increase bone marrow poly(ADP-ribose) and the latency of ethylnitrosourea-induced carcinogenesis in rats
    Ann C Boyonoski
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, ON, Canada N1G 2W1
    J Nutr 132:115-20. 2002
    ....
  8. ncbi request reprint Chronic DNA damage and niacin deficiency enhance cell injury and cause unusual interactions in NAD and poly(ADP-ribose) metabolism in rat bone marrow
    Jennifer C Spronck
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Nutr Cancer 45:124-31. 2003
    ....
  9. doi request reprint Niacin supplementation decreases the incidence of alkylation-induced nonlymphocytic leukemia in Long-Evans rats
    Anne Pascale Bartleman
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    Nutr Cancer 60:251-8. 2008
    ..Because nonlymphocytic leukemias represent the majority of secondary cancers, these data support the concept that niacin supplementation may help protect cancer patients from the deleterious side effects of chemotherapy...
  10. ncbi request reprint Niacin deficiency alters p53 expression and impairs etoposide-induced cell cycle arrest and apoptosis in rat bone marrow cells
    Jennifer C Spronck
    Department of Human Biology and Nutritional Sciences, University of Guelph, Ontario, Canada
    Nutr Cancer 57:88-99. 2007
    ..In conclusion, dietary niacin deficiency causes changes in NAD+ and pADPr metabolism, alters p53 expression, and impairs cellular responses to DNA damage...
  11. ncbi request reprint Water maze performance in young male Long-Evans rats is inversely affected by dietary intakes of niacin and may be linked to levels of the NAD+ metabolite cADPR
    Genevieve S Young
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    J Nutr 137:1050-7. 2007
    ..Changes in neural function related to the NAD(+) associated calcium signaling molecule, cADPR, may be the link between diet and behavior...
  12. ncbi request reprint Niacin and carcinogenesis
    James B Kirkland
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    Nutr Cancer 46:110-8. 2003
    ..There are various sources of evidence that niacin status does have an impact on cancer risk, including animal models of leukemogenesis and skin cancer, as well as epidemiological data from human populations...
  13. ncbi request reprint Niacin deficiency delays DNA excision repair and increases spontaneous and nitrosourea-induced chromosomal instability in rat bone marrow
    Lisa M Kostecki
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Mutat Res 625:50-61. 2007
    ....
  14. ncbi request reprint The guinea-pig is a poor animal model for studies of niacin deficiency and presents challenges in any study using purified diets
    Stephanie L Thorn
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    Br J Nutr 98:78-85. 2007
    ..We conclude that guinea-pigs are not suitable for research on niacin deficiency and they present challenges for any study requiring purified diets and wire-bottomed cages...
  15. ncbi request reprint The role of dietary niacin intake and the adenosine-5'-diphosphate-ribosyl cyclase enzyme CD38 in spatial learning ability: is cyclic adenosine diphosphate ribose the link between diet and behaviour?
    Genevieve S Young
    Department of Human Health and Nutritional Sciences, University of Guelph, Ontario, Canada
    Nutr Res Rev 21:42-55. 2008
    ....
  16. doi request reprint Niacin deficiency causes oxidative stress in rat bone marrow cells but not through decreased NADPH or glutathione status
    Kitty Tang
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    J Nutr Biochem 19:746-53. 2008
    ..Oxidative stress, of uncertain etiology, may play a role in the observed genomic instability and sensitivity to leukemogenesis in bone marrow cells during niacin deficiency...
  17. ncbi request reprint Decreased cADPR and increased NAD+ in the Cd38-/- mouse
    Genevieve S Young
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ont, Canada N1G 3W1
    Biochem Biophys Res Commun 346:188-92. 2006
    ..We also report significant increases in brain, lung, and kidney NAD(+) in the Cd38(-/-) mouse, and provide the first experimental demonstration of the proximate relationship between CD38 and NAD(+)...
  18. ncbi request reprint Modifications to increase the efficiency of the fluorometric cycling assay for cyclic ADP-ribose
    Genevieve S Young
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    Comb Chem High Throughput Screen 9:633-7. 2006
    ..We hope that these observations will encourage more widespread application of this valuable assay...
  19. ncbi request reprint Rat models of caloric intake and activity: relationships to animal physiology and human health
    Genevieve S Young
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, ON, Canada
    Appl Physiol Nutr Metab 32:161-76. 2007
    ....
  20. ncbi request reprint Niacin deficiency decreases bone marrow poly(ADP-ribose) and the latency of ethylnitrosourea-induced carcinogenesis in rats
    Ann C Boyonoski
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, ON, Canada N1G 2W1
    J Nutr 132:108-14. 2002
    ..These data show that niacin deficiency alters poly(ADP-ribose) metabolism in the bone marrow and increases the risk of nitrosourea-induced leukemias...
  21. ncbi request reprint Use of salient and non-salient visuospatial cues by rats in the Morris Water Maze
    Genevieve S Young
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    Physiol Behav 87:794-9. 2006
    ..This suggests that during place learning in Long-Evans rats, non-salient visual cues may play a dominant role, at least when salient cue presentation is limited to four cues...