Research Topics
| James B KirklandSummaryAffiliation: University of Guelph Country: Canada Publications
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Detail Information
Publications
Niacin status impacts chromatin structureJames B Kirkland
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
J Nutr 139:2397-401. 2009..These reactions produce a variety of localized effects in chromatin structure, and altered function in response to changes in niacin status may have dramatic effects on genomic stability, cell division and differentiation, and apoptosis...- Niacin requirements for genomic stabilityJames B Kirkland
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
Mutat Res 733:14-20. 2012..With exposure to stressors, like chemotherapy or excess sunlight, suraphysiological doses of niacin may be beneficial... 
Niacin status, NAD distribution and ADP-ribose metabolismJames B Kirkland
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
Curr Pharm Des 15:3-11. 2009..This article will explore what is known and yet to be learned about the response of tissues, cells and subcellular compartments to excessive and limiting supplies of niacin, and will discuss the etiology of the resulting pathologies...- Niacin status and treatment-related leukemogenesisJames B Kirkland
University of Guelph, Guelph, Ontario, Canada, N1G 2W1
Mol Cancer Ther 8:725-32. 2009.... - Poly ADP-ribose polymerase-1 and healthJames B Kirkland
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
Exp Biol Med (Maywood) 235:561-8. 2010..Promising new PARP-1 inhibitors may display interactions with dietary niacin status and may have long-term deleterious effects on genomic stability, but may be extremely valuable for the treatment of acute inflammatory conditions... - Niacin status and genomic instability in bone marrow cells; mechanisms favoring the progression of leukemogenesisJames B Kirkland
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada, N1G 2W1
Subcell Biochem 56:21-36. 2012.... - Pharmacological intakes of niacin increase bone marrow poly(ADP-ribose) and the latency of ethylnitrosourea-induced carcinogenesis in ratsAnn C Boyonoski
Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, ON, Canada N1G 2W1
J Nutr 132:115-20. 2002.... - Chronic DNA damage and niacin deficiency enhance cell injury and cause unusual interactions in NAD and poly(ADP-ribose) metabolism in rat bone marrowJennifer C Spronck
Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
Nutr Cancer 45:124-31. 2003.... - Niacin supplementation decreases the incidence of alkylation-induced nonlymphocytic leukemia in Long-Evans ratsAnne Pascale Bartleman
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
Nutr Cancer 60:251-8. 2008..Because nonlymphocytic leukemias represent the majority of secondary cancers, these data support the concept that niacin supplementation may help protect cancer patients from the deleterious side effects of chemotherapy... - Niacin deficiency alters p53 expression and impairs etoposide-induced cell cycle arrest and apoptosis in rat bone marrow cellsJennifer C Spronck
Department of Human Biology and Nutritional Sciences, University of Guelph, Ontario, Canada
Nutr Cancer 57:88-99. 2007..In conclusion, dietary niacin deficiency causes changes in NAD+ and pADPr metabolism, alters p53 expression, and impairs cellular responses to DNA damage... - Water maze performance in young male Long-Evans rats is inversely affected by dietary intakes of niacin and may be linked to levels of the NAD+ metabolite cADPRGenevieve S Young
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
J Nutr 137:1050-7. 2007..Changes in neural function related to the NAD(+) associated calcium signaling molecule, cADPR, may be the link between diet and behavior... - Niacin and carcinogenesisJames B Kirkland
Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
Nutr Cancer 46:110-8. 2003..There are various sources of evidence that niacin status does have an impact on cancer risk, including animal models of leukemogenesis and skin cancer, as well as epidemiological data from human populations... - Niacin deficiency delays DNA excision repair and increases spontaneous and nitrosourea-induced chromosomal instability in rat bone marrowLisa M Kostecki
Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
Mutat Res 625:50-61. 2007.... - The guinea-pig is a poor animal model for studies of niacin deficiency and presents challenges in any study using purified dietsStephanie L Thorn
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
Br J Nutr 98:78-85. 2007..We conclude that guinea-pigs are not suitable for research on niacin deficiency and they present challenges for any study requiring purified diets and wire-bottomed cages... - The role of dietary niacin intake and the adenosine-5'-diphosphate-ribosyl cyclase enzyme CD38 in spatial learning ability: is cyclic adenosine diphosphate ribose the link between diet and behaviour?Genevieve S Young
Department of Human Health and Nutritional Sciences, University of Guelph, Ontario, Canada
Nutr Res Rev 21:42-55. 2008.... - Niacin deficiency causes oxidative stress in rat bone marrow cells but not through decreased NADPH or glutathione statusKitty Tang
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
J Nutr Biochem 19:746-53. 2008..Oxidative stress, of uncertain etiology, may play a role in the observed genomic instability and sensitivity to leukemogenesis in bone marrow cells during niacin deficiency... - Decreased cADPR and increased NAD+ in the Cd38-/- mouseGenevieve S Young
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ont, Canada N1G 3W1
Biochem Biophys Res Commun 346:188-92. 2006..We also report significant increases in brain, lung, and kidney NAD(+) in the Cd38(-/-) mouse, and provide the first experimental demonstration of the proximate relationship between CD38 and NAD(+)... - Modifications to increase the efficiency of the fluorometric cycling assay for cyclic ADP-riboseGenevieve S Young
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
Comb Chem High Throughput Screen 9:633-7. 2006..We hope that these observations will encourage more widespread application of this valuable assay... - Rat models of caloric intake and activity: relationships to animal physiology and human healthGenevieve S Young
Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, ON, Canada
Appl Physiol Nutr Metab 32:161-76. 2007.... - Niacin deficiency decreases bone marrow poly(ADP-ribose) and the latency of ethylnitrosourea-induced carcinogenesis in ratsAnn C Boyonoski
Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, ON, Canada N1G 2W1
J Nutr 132:108-14. 2002..These data show that niacin deficiency alters poly(ADP-ribose) metabolism in the bone marrow and increases the risk of nitrosourea-induced leukemias... - Use of salient and non-salient visuospatial cues by rats in the Morris Water MazeGenevieve S Young
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
Physiol Behav 87:794-9. 2006..This suggests that during place learning in Long-Evans rats, non-salient visual cues may play a dominant role, at least when salient cue presentation is limited to four cues...