Malcolm King

Summary

Affiliation: University of Alberta
Country: Canada

Publications

  1. ncbi request reprint Physiology of mucus clearance
    Malcolm King
    Pulmonary Research Group, 173 Heritage Med Res Ctr, University of Alberta, Edmonton, AB, Canada T6G 2S2
    Paediatr Respir Rev 7:S212-4. 2006
  2. ncbi request reprint Mucomodulator therapy in cystic fibrosis: balancing mucus clearability against the spread of airborne pathogens
    Malcolm King
    Pulmonary Research Group, 173 Heritage Med Res Ctr, University of Alberta, Edmonton, AB T6G 2S2, Canada
    Pediatr Pulmonol Suppl 26:77-9. 2004
  3. ncbi request reprint Indigenous health part 2: the underlying causes of the health gap
    Malcolm King
    Department of Medicine, University of Alberta, Edmonton, AB, Canada
    Lancet 374:76-85. 2009
  4. doi request reprint An overall approach to health care for indigenous peoples
    Malcolm King
    University of Alberta Pulmonary Research Group, CIHR Institute of Aboriginal Peoples Health, University of Alberta, 173 HMRC University of Alberta, Edmonton, AB T6G 2S2, Canada
    Pediatr Clin North Am 56:1239-42. 2009
  5. ncbi request reprint Pharmacological approaches to discovery and development of new mucolytic agents
    Malcolm King
    University of Alberta Pulmonary Research Group, 173 Heritage Medical Research Center, Edmonton, Alberta T6G 2S2, Canada
    Adv Drug Deliv Rev 54:1475-90. 2002
  6. ncbi request reprint Rheology of cystic fibrosis sputum after in vitro treatment with hypertonic saline alone and in combination with recombinant human deoxyribonuclease I
    M King
    Pulmonary Research Group, University of Alberta, Edmonton, Canada
    Am J Respir Crit Care Med 156:173-7. 1997
  7. pmc A new paradigm in respiratory hygiene: modulating respiratory secretions to contain cough bioaerosol without affecting mucus clearance
    Gustavo Zayas
    University of Alberta Pulmonary Research Group, Edmonton, Canada
    BMC Pulm Med 7:11. 2007
  8. pmc Adaptation of an amphibian mucociliary clearance model to evaluate early effects of tobacco smoke exposure
    J Gustavo Zayas
    Mucobiology Research Unit, Pulmonary Research Group, University of Alberta, Edmonton, Canada
    Respir Res 5:9. 2004
  9. pmc Effectiveness of cough etiquette maneuvers in disrupting the chain of transmission of infectious respiratory diseases
    Gustavo Zayas
    Mucophysiology Laboratory, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada
    BMC Public Health 13:811. 2013
  10. ncbi request reprint Additive effect of dornase alfa and Nacystelyn on transportability and viscoelasticity of cystic fibrosis sputum
    Feng Sun
    Pulmonary Research Group, 173 Heritage Medical Research Centre, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
    Can Respir J 9:401-6. 2002

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Physiology of mucus clearance
    Malcolm King
    Pulmonary Research Group, 173 Heritage Med Res Ctr, University of Alberta, Edmonton, AB, Canada T6G 2S2
    Paediatr Respir Rev 7:S212-4. 2006
  2. ncbi request reprint Mucomodulator therapy in cystic fibrosis: balancing mucus clearability against the spread of airborne pathogens
    Malcolm King
    Pulmonary Research Group, 173 Heritage Med Res Ctr, University of Alberta, Edmonton, AB T6G 2S2, Canada
    Pediatr Pulmonol Suppl 26:77-9. 2004
  3. ncbi request reprint Indigenous health part 2: the underlying causes of the health gap
    Malcolm King
    Department of Medicine, University of Alberta, Edmonton, AB, Canada
    Lancet 374:76-85. 2009
    ..The topics covered include Indigenous notions of health and identity; mental health and addictions; urbanisation and environmental stresses; whole health and healing; and reconciliation...
  4. doi request reprint An overall approach to health care for indigenous peoples
    Malcolm King
    University of Alberta Pulmonary Research Group, CIHR Institute of Aboriginal Peoples Health, University of Alberta, 173 HMRC University of Alberta, Edmonton, AB T6G 2S2, Canada
    Pediatr Clin North Am 56:1239-42. 2009
    ....
  5. ncbi request reprint Pharmacological approaches to discovery and development of new mucolytic agents
    Malcolm King
    University of Alberta Pulmonary Research Group, 173 Heritage Medical Research Center, Edmonton, Alberta T6G 2S2, Canada
    Adv Drug Deliv Rev 54:1475-90. 2002
    ..Further studies are required to confirm these findings, to perform direct assessments of mucus clearability, and to extend the observations to patients with various types of pulmonary diseases where mucoactive treatments are required...
  6. ncbi request reprint Rheology of cystic fibrosis sputum after in vitro treatment with hypertonic saline alone and in combination with recombinant human deoxyribonuclease I
    M King
    Pulmonary Research Group, University of Alberta, Edmonton, Canada
    Am J Respir Crit Care Med 156:173-7. 1997
    ..These in vitro results suggest that combined treatment with rhDNase and HS should be evaluated further as a potential mucotropic approach to augment the clearance of purulent sputum in CF lung disease...
  7. pmc A new paradigm in respiratory hygiene: modulating respiratory secretions to contain cough bioaerosol without affecting mucus clearance
    Gustavo Zayas
    University of Alberta Pulmonary Research Group, Edmonton, Canada
    BMC Pulm Med 7:11. 2007
    ....
  8. pmc Adaptation of an amphibian mucociliary clearance model to evaluate early effects of tobacco smoke exposure
    J Gustavo Zayas
    Mucobiology Research Unit, Pulmonary Research Group, University of Alberta, Edmonton, Canada
    Respir Res 5:9. 2004
    ..The respiratory system has to undergo an iterative process of injury, healing and remodeling with every exposure...
  9. pmc Effectiveness of cough etiquette maneuvers in disrupting the chain of transmission of infectious respiratory diseases
    Gustavo Zayas
    Mucophysiology Laboratory, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada
    BMC Public Health 13:811. 2013
    ..The objective of the current study was to determine the effectiveness of simple primary respiratory hygiene/cough etiquette maneuvers in blocking droplets expelled as aerosol during coughing...
  10. ncbi request reprint Additive effect of dornase alfa and Nacystelyn on transportability and viscoelasticity of cystic fibrosis sputum
    Feng Sun
    Pulmonary Research Group, 173 Heritage Medical Research Centre, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
    Can Respir J 9:401-6. 2002
    ....
  11. pmc Recent epidemiologic trends of diabetes mellitus among status Aboriginal adults
    Richard T Oster
    Department of Medicine, University of Alberta, Edmonton, Alta
    CMAJ 183:E803-8. 2011
    ..We compared the incidence and prevalence of diabetes, and its impact on mortality, among status Aboriginal adults and adults in the general population between 1995 and 2007...
  12. pmc Cough aerosol in healthy participants: fundamental knowledge to optimize droplet-spread infectious respiratory disease management
    Gustavo Zayas
    Mucophysiology Laboratory, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada
    BMC Pulm Med 12:11. 2012
    ..The objective of the current study was to characterize the human cough aerosol pattern with the aim of developing a standard human cough bioaerosol model for Influenza Pandemic control...
  13. pmc Effect of needle puncture and electro-acupuncture on mucociliary clearance in anesthetized quails
    Shusheng Tai
    Pulmonary Research Group, 173 Heritage Medical Research Center, University of Alberta, Edmonton, AB T6G 2S2, Canada
    BMC Complement Altern Med 6:4. 2006
    ....
  14. ncbi request reprint Lung delivery of aerosolized dextran
    W H Finlay
    Aerosol Research Laboratory, Department of Mechanical Engineering, University of Alberta, Edmonton, Alberta, Canada
    Am J Respir Crit Care Med 161:91-7. 2000
    ..5-ml volume fill and a dextran concentration of 200 mg/ml...
  15. pmc Prevalence of asthma and chronic obstructive pulmonary disease in Aboriginal and non-Aboriginal populations: a systematic review and meta-analysis of epidemiological studies
    Maria B Ospina
    School of Public Health, Faculty of Medicine and Dentisttry, University of Alberta, Edmonton, Alberta
    Can Respir J 19:355-60. 2012
    ..Asthma and chronic obstructive pulmonary disease (COPD) have considerable potential for inequities in diagnosis and treatment, thereby affecting vulnerable groups...
  16. pmc A mechanism of airway injury in an epithelial model of mucociliary clearance
    Darryl W O'Brien
    Pulmonary Research Group, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Respir Res 5:10. 2004
    ....
  17. pmc A new paradigm in respiratory hygiene: increasing the cohesivity of airway secretions to improve cough interaction and reduce aerosol dispersion
    Gustavo Zayas
    Pulmonary Research Group, University of Alberta, Edmonton, Canada
    BMC Pulm Med 5:11. 2005
    ..Our goal is to reduce the aerosolizability of respiratory secretions while interfering only minimally with normal mucus clearance using agents capable of increasing crosslinking in the mucin glycoprotein network...
  18. ncbi request reprint Diabetes in pregnancy among First Nations women in Alberta, Canada: a retrospective analysis
    Richard T Oster
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    BMC Pregnancy Childbirth 14:136. 2014
    ..We generated a comprehensive epidemiological profile of diabetes in pregnancy over a 10-year period among the First Nations population of Alberta, Canada...
  19. ncbi request reprint Health inequities experienced by Aboriginal children with respiratory conditions and their parents
    Miriam Stewart
    Faculty of Nursing and Social Support Research Program, University of Alberta, Edmonton, Canada
    Can J Nurs Res 45:6-27. 2013
    ..These children, adolescents, and parents recommended the establishment of culturally appropriate support and education programs delivered by Aboriginal peers and health professionals...
  20. ncbi request reprint High rates of the metabolic syndrome in a First Nations Community in western Canada: prevalence and determinants in adults and children
    Sharndeep Norry Kaler
    Heritage Research Medical Center, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Int J Circumpolar Health 65:389-402. 2006
    ..Some prevalence information for American Indians exists, but little has been available for Canada's First Nations...
  21. ncbi request reprint Collection and analysis of respiratory mucus from subjects without lung disease
    B K Rubin
    University of Alberta Pulmonary Defense Group, Department of Paediatrics, Edmonton, Canada
    Am Rev Respir Dis 141:1040-3. 1990
    ..This technique for mucus collection allows us to study alterations in mucus properties in patients with and without pulmonary disease at the time of incidental surgery.(ABSTRACT TRUNCATED AT 250 WORDS)..
  22. ncbi request reprint General anesthesia does not alter the viscoelastic or transport properties of human respiratory mucus
    B K Rubin
    University of Alberta, Department of Pediatrics Pulmonary, Edmonton, Canada
    Chest 98:101-4. 1990
    ..The decrease in MTR during general anesthesia is probably due to mechanisms other than alterations in the physical properties of mucus...
  23. ncbi request reprint Recurrent respiratory infections in a child with fucosidosis: is the mucus too thin for effective transport?
    B K Rubin
    Department of Pediatrics, University of Alberta Hospitals, Edmonton, Canada
    Pediatr Pulmonol 10:304-9. 1991
    ..This leads to mucus that is abnormally watery and thus difficult to clear from the airway...
  24. ncbi request reprint Marked disparity in the epidemiology of tuberculosis among Aboriginal peoples on the Canadian prairies: the challenges and opportunities
    Richard Long
    Department of Medicine, University of Alberta, Edmonton
    Can Respir J 20:223-30. 2013
    ..While it is established that Aboriginal peoples in the prairie provinces of Canada are disproportionately affected by tuberculosis (TB), little is known about the epidemiology of TB either within or across provincial borders...
  25. ncbi request reprint Increasing incidence and prevalence of diabetes among the Status Aboriginal population in urban and rural Alberta, 1995-2006
    Jeffrey A Johnson
    Department of Public Health Sciences, School of Public Health, University of Alberta, Edmonton, AB
    Can J Public Health 100:231-6. 2009
    ..To compare changes in diagnosed diabetes prevalence and incidence among Status Aboriginal men and women living in urban and rural areas of Alberta...
  26. pmc A rapid point of care immunoswab assay for SARS-CoV detection
    Sriram Kammila
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 11304 89 Avenue, Edmonton, Alberta, Canada T6G 2N8
    J Virol Methods 152:77-84. 2008
    ..The key feature of this simple immunoswab diagnostic assay is its ability to detect the presence of the SARS-CoV antigen within 45-60 min with the availability of the body fluid samples...
  27. pmc Regulation of Cl- secretion by alpha2-adrenergic receptors in mouse colonic epithelium
    Rebecca S Lam
    Department of Physiology, University of Alberta, Edmonton, Canada T6G 2H7
    J Physiol 548:475-84. 2003
    ..In summary, alpha2ARs inhibit anion secretion in colonic epithelia by acting on basolateral KATP channels, through a process that does not involve classical second messengers...
  28. ncbi request reprint Ophiopogon root (Radix Ophiopogonis) prevents ultra-structural damage by SO2 in an epithelial injury model for studies of mucociliary transport
    D W O'Brien
    Heritage Medical Research Centre, Room 173, Pulmonary Research Group, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
    Life Sci 74:2413-22. 2004
    ..In OR-incubated palates, mucociliary transport was completely restored within 20 min after topical application of MB, possibly through a protective action on the extra-cellular matrix...
  29. ncbi request reprint Thioredoxin liquefies and decreases the viscoelasticity of cystic fibrosis sputum
    Raymond C Rancourt
    National Jewish Medical and Research Center, 1400 Jackson St, Denver, CO 80206, USA
    Am J Physiol Lung Cell Mol Physiol 286:L931-8. 2004
    ..Recognizing that mucins are the major gel-forming glycoproteins in mucus, we suggest that Trx alters sputum rheology by enzymatic reduction of glycoprotein polymers present in sputum...
  30. pmc Effects of intravenous furosemide on mucociliary transport and rheological properties of patients under mechanical ventilation
    Cláudia Seiko Kondo
    Universidade de Sao Paulo, Sao Paulo, Brazil
    Crit Care 6:81-7. 2002
    ..The remaining parameters did not change significantly in either group. Our results support the hypothesis that IV furosemide might acutely impair MCT in patients under MV...
  31. ncbi request reprint Long term azithromycin therapy in cystic fibrosis patients: a study on drug levels and sputum properties
    Ulrich Baumann
    Department of Pediatric Pulmonology and Neonatology, Hanover Medical School, Hanover, Germany
    Can Respir J 11:151-5. 2004
    ..However, the underlying mechanisms remain uncertain. Some macrolides, including AZM, display inhibition of virulence factors and other antipseudomonal effects at subinhibitory levels in vitro...