Young In Kim

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi request reprint Severe folate deficiency impairs natural killer cell-mediated cytotoxicity in rats
    Young In Kim
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Nutr 132:1361-7. 2002
  2. doi request reprint Folic acid supplementation promotes mammary tumor progression in a rat model
    Shaidah Deghan Manshadi
    Department of Nutritional Sciences, University of Toronto and Keenan Research Center for Biomedical Science at St Michael s Hospital, Toronto, Ontario, Canada
    PLoS ONE 9:e84635. 2014
  3. ncbi request reprint Colonic mucosal concentrations of folate correlate well with blood measurements of folate status in persons with colorectal polyps
    Y I Kim
    Department of Medicine, St Michael s Hospital, and the University of Toronto, Ontario, Canada
    Am J Clin Nutr 68:866-72. 1998
  4. ncbi request reprint Folate and colorectal cancer: an evidence-based critical review
    Young In Kim
    Department of Medicine and Nutritional Sciences, Medical Sciences Building, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada
    Mol Nutr Food Res 51:267-92. 2007
  5. ncbi request reprint Does a high folate intake increase the risk of breast cancer?
    Young In Kim
    Department of Medicine and Nutritional Sciences, University of Toronto, Division of Gastroenterology, St Michael s Hospital, Toronto, Canada
    Nutr Rev 64:468-75. 2006
  6. pmc Folate: a magic bullet or a double edged sword for colorectal cancer prevention?
    Y I Kim
    University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada
    Gut 55:1387-9. 2006
  7. ncbi request reprint 5,10-Methylenetetrahydrofolate reductase polymorphisms and pharmacogenetics: a new role of single nucleotide polymorphisms in the folate metabolic pathway in human health and disease
    Young In Kim
    Department of Medicine, University of Toronto, Division of Gastroenterology, St Michael s Hospital, Room 7258, Medical Sciences Building, 1 King s College Circle, Toronto, Ontario, Canada M5S 1A8
    Nutr Rev 63:398-407. 2005
  8. ncbi request reprint Folate and DNA methylation: a mechanistic link between folate deficiency and colorectal cancer?
    Young In Kim
    Departments of Medicine and Nutritional Sciences, University of Toronto, Medical Sciences Building Room 7258, 1 King s College Circle, Toronto, Ontario, Canada M5S 1A8
    Cancer Epidemiol Biomarkers Prev 13:511-9. 2004
  9. ncbi request reprint Folate, colorectal carcinogenesis, and DNA methylation: lessons from animal studies
    Young In Kim
    Departments of Medicine and Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    Environ Mol Mutagen 44:10-25. 2004
  10. ncbi request reprint Nutritional epigenetics: impact of folate deficiency on DNA methylation and colon cancer susceptibility
    Young In Kim
    Departments of Medicine and Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    J Nutr 135:2703-9. 2005

Collaborators

Detail Information

Publications56

  1. ncbi request reprint Severe folate deficiency impairs natural killer cell-mediated cytotoxicity in rats
    Young In Kim
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Nutr 132:1361-7. 2002
    ..These data collectively suggest that NK-mediated cytotoxicity is not a likely mechanism by which folate status modulates carcinogenesis...
  2. doi request reprint Folic acid supplementation promotes mammary tumor progression in a rat model
    Shaidah Deghan Manshadi
    Department of Nutritional Sciences, University of Toronto and Keenan Research Center for Biomedical Science at St Michael s Hospital, Toronto, Ontario, Canada
    PLoS ONE 9:e84635. 2014
    ..The potential tumor-promoting effect of folic acid supplementation in breast cancer patients and survivors needs further clarification. ..
  3. ncbi request reprint Colonic mucosal concentrations of folate correlate well with blood measurements of folate status in persons with colorectal polyps
    Y I Kim
    Department of Medicine, St Michael s Hospital, and the University of Toronto, Ontario, Canada
    Am J Clin Nutr 68:866-72. 1998
    ..This issue is important for assessing folate status in the colorectal mucosa because low dietary intake or blood concentrations of folate are associated with an increased risk of colorectal neoplasia...
  4. ncbi request reprint Folate and colorectal cancer: an evidence-based critical review
    Young In Kim
    Department of Medicine and Nutritional Sciences, Medical Sciences Building, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada
    Mol Nutr Food Res 51:267-92. 2007
    ..Based on the lack of compelling supportive evidence and on the potential tumor-promoting effect, routine folic acid supplementation should not be recommended as a chemopreventive measure against CRC at present...
  5. ncbi request reprint Does a high folate intake increase the risk of breast cancer?
    Young In Kim
    Department of Medicine and Nutritional Sciences, University of Toronto, Division of Gastroenterology, St Michael s Hospital, Toronto, Canada
    Nutr Rev 64:468-75. 2006
    ..Based on the lack of compelling supportive evidence, routine folic acid supplementation should not be recommended as a chemopreventive measure against breast cancer at present...
  6. pmc Folate: a magic bullet or a double edged sword for colorectal cancer prevention?
    Y I Kim
    University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada
    Gut 55:1387-9. 2006
  7. ncbi request reprint 5,10-Methylenetetrahydrofolate reductase polymorphisms and pharmacogenetics: a new role of single nucleotide polymorphisms in the folate metabolic pathway in human health and disease
    Young In Kim
    Department of Medicine, University of Toronto, Division of Gastroenterology, St Michael s Hospital, Room 7258, Medical Sciences Building, 1 King s College Circle, Toronto, Ontario, Canada M5S 1A8
    Nutr Rev 63:398-407. 2005
    ....
  8. ncbi request reprint Folate and DNA methylation: a mechanistic link between folate deficiency and colorectal cancer?
    Young In Kim
    Departments of Medicine and Nutritional Sciences, University of Toronto, Medical Sciences Building Room 7258, 1 King s College Circle, Toronto, Ontario, Canada M5S 1A8
    Cancer Epidemiol Biomarkers Prev 13:511-9. 2004
    ..However, there is still a possibility that sequence-specific alterations of DNA methylation in critical cancer-related genes might be mechanistically involved in the folate deficiency-mediated colorectal carcinogenesis...
  9. ncbi request reprint Folate, colorectal carcinogenesis, and DNA methylation: lessons from animal studies
    Young In Kim
    Departments of Medicine and Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    Environ Mol Mutagen 44:10-25. 2004
    ..A mechanistic understanding of how folate status modulates colorectal carcinogenesis further strengthens the case for a causal relationship and provides insight into a possible chemopreventive role of folate...
  10. ncbi request reprint Nutritional epigenetics: impact of folate deficiency on DNA methylation and colon cancer susceptibility
    Young In Kim
    Departments of Medicine and Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    J Nutr 135:2703-9. 2005
    ....
  11. ncbi request reprint Will mandatory folic acid fortification prevent or promote cancer?
    Young In Kim
    Department of Medicine and Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    Am J Clin Nutr 80:1123-8. 2004
    ..The potential cancer-promoting effect of folic acid supplementation needs to be considered in carefully monitoring the long-term effect of folic acid fortification on the vast majority of the US population, who are not at risk of NTDs...
  12. ncbi request reprint Folic acid fortification and supplementation--good for some but not so good for others
    Young In Kim
    Department of Medicine, University of Toronto, Toronto, Canada
    Nutr Rev 65:504-11. 2007
    ....
  13. ncbi request reprint The effect of dietary folate on genomic and p53-specific DNA methylation in rat colon
    Kyoung Jin Sohn
    Department of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada
    Carcinogenesis 24:81-90. 2003
    ..This implies that neither genomic or p53 hypomethylation within exons 6-7 nor aberrant p53 methylation within the promoter region is likely a mechanism by which folate deficiency enhances colorectal carcinogenesis in the rat...
  14. ncbi request reprint Effects of dietary folate on DNA strand breaks within mutation-prone exons of the p53 gene in rat colon
    Y I Kim
    Division of Gastroenterology, Department of Medicine, St Michael s Hospital and University of Toronto, Toronto, Ontario, Canada
    Gastroenterology 119:151-61. 2000
    ..This study investigated the effects of dietary folate on DNA strand breaks in the p53 and Apc genes, and how these changes are related to steady-state levels of the corresponding transcripts...
  15. doi request reprint Role of the MTHFR polymorphisms in cancer risk modification and treatment
    Young In Kim
    Department of Medicine, Room 7258, Medical Sciences Building, University of Toronto, 1 King s College Circle, Toronto, Ontario, M5S 1A8, Canada
    Future Oncol 5:523-42. 2009
    ..As such, largescale human studies and in vitro mechanistic studies are warranted to clarify the pharmacogenetic role of the MTHFR SNPs...
  16. ncbi request reprint Cell and stage of transformation-specific effects of folate deficiency on methionine cycle intermediates and DNA methylation in an in vitro model
    Joanne M Stempak
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada, M5S 1A8
    Carcinogenesis 26:981-90. 2005
    ..Moreover, the effect of folate deficiency on DNA methylation appears to be mediated by both methionine cycle intermediate-dependent and independent pathways...
  17. ncbi request reprint Colonic mucosal concentrations of folate are accurately predicted by blood measurements of folate status among individuals ingesting physiologic quantities of folate
    Y I Kim
    Department of Medicine, University of Toronto and St Michael s Hospital, Toronto, Ontario, M5S 1A8 Canada
    Cancer Epidemiol Biomarkers Prev 10:715-9. 2001
    ..Our observations indicate that colonic mucosal concentrations of folate may be predicted accurately by blood measurements of folate status only among individuals not ingesting supraphysiological quantities of folate...
  18. doi request reprint Folic acid supplementation and cancer risk: point
    Young In Kim
    Department of Medicine, University of Toronto, St Michael s Hospital, Toronto, Ontario, Canada
    Cancer Epidemiol Biomarkers Prev 17:2220-5. 2008
  19. ncbi request reprint Role of folate in colon cancer development and progression
    Young In Kim
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Nutr 133:3731S-3739S. 2003
    ..Notwithstanding the limitations associated with animal models, these animal studies suggest that the optimal timing and dose of folate intervention need to be established for safe and effective chemoprevention in humans...
  20. ncbi request reprint Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexate
    Kyoung Jin Sohn
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Natl Cancer Inst 96:134-44. 2004
    ....
  21. doi request reprint Effect of maternal and postweaning folic acid supplementation on colorectal cancer risk in the offspring
    Karen K Y Sie
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    Gut 60:1687-94. 2011
    ..The effect of maternal and postweaning folic acid supplementation on colorectal cancer risk in the offspring was investigated...
  22. pmc The methylenetetrahydrofolate reductase C677T mutation induces cell-specific changes in genomic DNA methylation and uracil misincorporation: a possible molecular basis for the site-specific cancer risk modification
    Kyoung Jin Sohn
    Department of Medicine, University of Toronto, St Michael s Hospital, Toronto, Ontario, Canada
    Int J Cancer 124:1999-2005. 2009
    ....
  23. doi request reprint Effect of maternal and postweaning folic acid supplementation on mammary tumor risk in the offspring
    Anna Ly
    Department of Nutritional Sciences, University of Toronto, Ontario, Canada
    Cancer Res 71:988-97. 2011
    ..Further, they suggest that this tumor-promoting effect may be mediated in part by altered DNA methylation and DNMT activity...
  24. doi request reprint Effect of maternal and postweaning folic acid supplementation on global and gene-specific DNA methylation in the liver of the rat offspring
    Karen K Y Sie
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    Mol Nutr Food Res 57:677-85. 2013
    ..We investigated the effect of maternal and postweaning folic acid supplementation on DNA methylation in the rat offspring...
  25. ncbi request reprint Effects of dietary folate on the development and progression of mammary tumors in rats
    Joanne Kotsopoulos
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    Carcinogenesis 26:1603-12. 2005
    ..However, the limitations associated with the route and dose of MNU administration preclude a definitive conclusion concerning the effect of folate status on the initiation of MNU-induced mammary tumorigenesis...
  26. ncbi request reprint Effects of dietary folate on ulcerative colitis-associated colorectal carcinogenesis in the interleukin 2- and beta(2)-microglobulin-deficient mice
    Julie Carrier
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Cancer Epidemiol Biomarkers Prev 12:1262-7. 2003
    ..However, the high mortality observed in the folate-deficient group precludes a definitive conclusion concerning the effect of folate deficiency on UC-associated colorectal carcinogenesis in this model...
  27. ncbi request reprint Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells
    Petar Novakovic
    Institute of Medical Science, Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    Carcinogenesis 27:916-24. 2006
    ....
  28. doi request reprint Effect of folic acid supplementation on the progression of colorectal aberrant crypt foci
    Gillian M Lindzon
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    Carcinogenesis 30:1536-43. 2009
    ..34; P < 0.001) and inversely with plasma homocysteine concentrations (r = -0.37; P < 0.001). Our data suggest that folic acid supplementation may promote the progression of ACF to colorectal tumors...
  29. pmc High folate gestational and post-weaning diets alter hypothalamic feeding pathways by DNA methylation in Wistar rat offspring
    Clara E Cho
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada
    Epigenetics 8:710-9. 2013
    ..Our work is novel in showing post-weaning epigenetic plasticity of the hypothalamus and that in utero programming by vitamin gestational diets can be modified by vitamin content of the pup diet. ..
  30. ncbi request reprint Folate deficiency induces cell-specific changes in the steady-state transcript levels of genes involved in folate metabolism and 1-carbon transfer reactions in human colonic epithelial cells
    Inki Hayashi
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada, M5S 1A8
    J Nutr 137:607-13. 2007
    ..In both HCT116 and Caco2 cells, folate depletion was associated with the conservation of the existing pattern and extent of DNA methylation...
  31. ncbi request reprint Effects of folate and folylpolyglutamyl synthase modulation on chemosensitivity of breast cancer cells
    Robert C Cho
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    Mol Cancer Ther 6:2909-20. 2007
    ..Whether or not FPGS modulation may be an important clinical determinant of chemosensitivity of breast cancer cells to 5FU and methotrexate-based chemotherapy needs further exploration...
  32. ncbi request reprint Postweaning dietary folate deficiency provided through childhood to puberty permanently increases genomic DNA methylation in adult rat liver
    Joanne Kotsopoulos
    Department of Nutritional Sciences, University of Toronto, Toronto, Canada, M5S 1A8
    J Nutr 138:703-9. 2008
    ..Our data suggest that early folate nutrition during postnatal development plays an important role in epigenetic programming that can have a permanent effect in adulthood...
  33. ncbi request reprint Msh2 deficiency enhances somatic Apc and p53 mutations in Apc+/-Msh2-/- mice
    Kyoung Jin Sohn
    Department of Medicine, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
    Carcinogenesis 24:217-24. 2003
    ..The nature and frequency of somatic Apc and p53 mutations in Apc+/-Msh2-/- mice suggest that many genomic sites, in addition to genes containing simple repeated sequences, are at risk of somatic mutations associated with Msh2 deficiency...
  34. ncbi request reprint Chemopreventive effects of dietary folate on intestinal polyps in Apc+/-Msh2-/- mice
    J Song
    Department of Nutritional Sciences, University of Toronto, Ontario, Canada
    Cancer Res 60:3191-9. 2000
    ....
  35. doi request reprint Folate and breast cancer: what about high-risk women?
    Joanne Kotsopoulos
    Women s College Research Institute, Women s College Hospital, 790 Bay Street, 7th Floor, Room 710, Toronto, ON M5G IN8, Canada
    Cancer Causes Control 23:1405-20. 2012
    ..Our goal is to develop practical and safe interventions for high-risk women leading to a decrease in the number of breast cases and deaths attributed to breast cancer...
  36. doi request reprint Folic acid supplementation provided in utero and during lactation reduces the number of terminal end buds of the developing mammary glands in the offspring
    Karen K Y Sie
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    Cancer Lett 280:72-7. 2009
    ..014). Our data suggest for the first time that folic acid supplementation provided in utero and during lactation may lower mammary tumor risk in the offspring...
  37. pmc A pilot randomised controlled trial to reduce colorectal cancer risk markers associated with B-vitamin deficiency, insulin resistance and colonic inflammation
    W R Bruce
    Department of Nutritional Sciences, University of Toronto, 150 College Street, and Division of Gastroenterology, St Michael s Hospital, Toronto, Ontario, Canada M5S 2E3
    Br J Cancer 93:639-46. 2005
    ..We suggest that long-term intervention studies with tumour-related end points should be undertaken when the intervention agents used are found effective in short-term biochemical risk marker trials...
  38. ncbi request reprint Effects of dietary folate on intestinal tumorigenesis in the apcMin mouse
    J Song
    Department of Medicine, University of Toronto, Ontario, Canada
    Cancer Res 60:5434-40. 2000
    ..Notwithstanding the limitations associated with this model, these data suggest that the optimal timing and dose of folate intervention need to be determined for safe and effective folate chemoprevention...
  39. ncbi request reprint Effects of folate supplementation on two provisional molecular markers of colon cancer: a prospective, randomized trial
    Y I Kim
    Department of Medicine, University of Toronto and St Michael's Hospital, Ontario, Canada
    Am J Gastroenterol 96:184-95. 2001
    ..Therefore, potential confounding factors that seem to modulate these biomarkers need to be identified and corrected in order for these markers to serve as suitable surrogate endpoints in folate chemoprevention trials...
  40. doi request reprint Folate and DNA methylation
    Anna Ly
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Antioxid Redox Signal 17:302-26. 2012
    ..Aberrant patterns and dysregulation of DNA methylation are mechanistically related to carcinogenesis...
  41. ncbi request reprint A patient with anemia of obscure origin: Crohn's disease in disguise
    Elena Dubcenco
    Department of Medicine, University of Toronto and St Michael s Hospital, Toronto, ON, Canada
    Nat Clin Pract Gastroenterol Hepatol 3:229-33; quiz following 233. 2006
    ..He had a medical history of beta thalassemia and fecal occult blood tests had occasionally been positive...
  42. doi request reprint Folate is absorbed across the colon of adults: evidence from cecal infusion of (13)C-labeled [6S]-5-formyltetrahydrofolic acid
    Susanne Aufreiter
    Department of Nutritional Sciences, University of Toronto, Toronto, Canada
    Am J Clin Nutr 90:116-23. 2009
    ..It is well known that the microflora in the colon produce large quantities of folate that approach or exceed recommended dietary intakes; however, there is no direct evidence of the bioavailability of this pool in humans...
  43. ncbi request reprint Does perioperative immunonutrition reduce postoperative complications in patients with gastrointestinal cancer undergoing operations?
    David N Moskovitz
    Department of Medicine, Division of Gastroenterology, University of Toronto, St Michael s Hospital, Medical Sciences Building, 1 King s College Circle, Toronto, Ontario, Canada M5S 1A8
    Nutr Rev 62:443-7. 2004
    ..Both pre- and perioperative immunonutritional strategies were superior to the conventional approach (no artificial nutrition perioperatively)...
  44. doi request reprint Duodenal gastrinoma with multiple gastric neuroendocrine tumors secondary to chronic Helicobacter pylori gastritis
    Andrea Grin
    Departments of Laboratory Medicine and Pathobiology, St Michael s Hospital, Toronto, ON, Canada
    Am J Surg Pathol 36:935-40. 2012
    ....
  45. ncbi request reprint Molecular genetics of ulcerative colitis-associated colon cancer in the interleukin 2- and beta(2)-microglobulin-deficient mouse
    K J Sohn
    Department of Medicine, University of Toronto, Toronto, Ontario, M5S 1A8 Canada
    Cancer Res 61:6912-7. 2001
    ..As such, this model appears to be an excellent animal model to study UC-associated colorectal carcinogenesis...
  46. ncbi request reprint Vegetables, fruits, and colorectal cancer risk: what should we believe?
    Y I Kim
    Department of Medicine, University of Toronto, Ontario, Canada
    Nutr Rev 59:394-8. 2001
    ....
  47. ncbi request reprint Folate and methylenetetrahydrofolate reductase polymorphisms: new nutritional and genetic risk factors for pancreatic cancer?
    Young In Kim
    Clin Gastroenterol Hepatol 3:738-42. 2005
  48. ncbi request reprint Is folic acid good for everyone?
    A David Smith
    Oxford Project to Investigate Memory and Ageing, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom
    Am J Clin Nutr 87:517-33. 2008
    ..Only then can authorities develop the right strategies for the population as a whole...
  49. ncbi request reprint Folate and colo-rectal cancer risk
    Peter Sanderson
    Nutrition Division, Food Standards Agency, London WC2 6NH, UK
    Br J Nutr 98:1299-304. 2007
    ..Also, the need to study further the influence of genetically defined subgroups was highlighted for future research...
  50. ncbi request reprint Resistance to cytotoxic chemotherapy is induced by NK cells in non-Hodgkin's Lymphoma Cells
    Daeho Cho
    Department of Life Science, Sookmyung Women s University
    J Clin Immunol 24:553-60. 2004
    ..Taken together, these results suggest that B lymphoma cell resistance to doxorubicin-mediated cell death is induced by coculture with NK cells, because of TNF alpha secretion...
  51. ncbi request reprint Canadian Association of Gastroenterology and the Canadian Digestive Health Foundation: Guidelines on colon cancer screening
    Desmond Leddin
    Department of Medicine, Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia
    Can J Gastroenterol 18:93-9. 2004
  52. ncbi request reprint Point mutations affecting the oligomeric structure of Nm23-H1 abrogates its inhibitory activity on colonization and invasion of prostate cancer cells
    Young In Kim
    Vascular System Research Center, Division of Life Sciences, College of Natural Sciences, Kangwon National University, Chunchon, Republic of Korea
    Biochem Biophys Res Commun 307:281-9. 2003
    ..These correlative data suggest that the metastasis-suppressing activity of Nm23-H1 may depend on its oligomeric structure, but not on its NDP kinase activity...
  53. ncbi request reprint L-ascorbic acid (vitamin C) induces the apoptosis of B16 murine melanoma cells via a caspase-8-independent pathway
    Jae Seung Kang
    Department of Anatomy and Tumor Immunity Medical Research Center, Seoul National University College of Medicine, 110 799 Seoul, South Korea
    Cancer Immunol Immunother 52:693-8. 2003
    ....
  54. pmc CpG DNA prevents liver injury and shock-mediated death by modulating expression of interleukin-1 receptor-associated kinases
    Young In Kim
    The Children s Foundation Research Center at Le Bonheur Children s Medical Center, and Department of Pediatrics, University of Tennessee Health Science Center, 50 N Dunlap Street, Memphis, TN 38103, USA
    J Biol Chem 283:15258-70. 2008
    ....
  55. ncbi request reprint CM1 ligation initiates apoptosis in a caspase 8-dependent manner in Ramos cells and in a mitochondria-controlled manner in Raji cells
    Daejin Kim
    Department of Anatomy, Seoul National University, College of Medicine and Institute of Allergy and Clinical Immunology, Medical Research Center, Seoul National University, Seoul, South Korea
    Hum Immunol 63:576-87. 2002
    ..Moreover, the effector caspase inhibitor, z-DEVD, blocked CM1-mediated apoptosis in both cell lines. We found that CM1-induced apoptosis is achieved via different initiation pathways, which are cell-type dependent...
  56. pmc Protein kinase D1: a new component in TLR9 signaling
    Jeoung Eun Park
    Children s Foundation Research Center at Le Bonheur Children s Medical Center and Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38103, USA
    J Immunol 181:2044-55. 2008
    ..Our findings identify PKD1 as a key signaling modulator in TLR9-mediated macrophage activation...