Young In Kim
Affiliation: University of Toronto
Stempak J, Sohn K, Chiang E, Shane B, Kim Y. Cell and stage of transformation-specific effects of folate deficiency on methionine cycle intermediates and DNA methylation in an in vitro model. Carcinogenesis. 2005;26:981-90 pubmed
..Moreover, the effect of folate deficiency on DNA methylation appears to be mediated by both methionine cycle intermediate-dependent and independent pathways. ..
Visentin C, Masih S, Plumptre L, Malysheva O, Nielsen D, Sohn K, et al
. Maternal Choline Status, but Not Fetal Genotype, Influences Cord Plasma Choline Metabolite Concentrations. J Nutr. 2015;145:1491-7 pubmed publisher
..These data collectively indicate that maternal choline status, but not fetal genotype, influences cord plasma concentrations of choline metabolites. This trial was registered at clinicaltrials.gov as NCT02244684. ..
Plumptre L, Masih S, Ly A, Aufreiter S, Sohn K, Croxford R, et al
. High concentrations of folate and unmetabolized folic acid in a cohort of pregnant Canadian women and umbilical cord blood. Am J Clin Nutr. 2015;102:848-57 pubmed publisher
..This study was registered at www.clinicaltrials.gov as NCT02244684. ..
Sohn K, Stempak J, Reid S, Shirwadkar S, Mason J, Kim Y. The effect of dietary folate on genomic and p53-specific DNA methylation in rat colon. Carcinogenesis. 2003;24:81-90 pubmed
..This implies that neither genomic or p53 hypomethylation within exons 6-7 nor aberrant p53 methylation within the promoter region is likely a mechanism by which folate deficiency enhances colorectal carcinogenesis in the rat. ..
Ly A, Ishiguro L, Kim D, Im D, Kim S, Sohn K, et al
. Maternal folic acid supplementation modulates DNA methylation and gene expression in the rat offspring in a gestation period-dependent and organ-specific manner. J Nutr Biochem. 2016;33:103-10 pubmed publisher
..Maternal folic acid supplementation affects tissue folate concentrations, DNA methylation and gene expression in the offspring in a gestation-period-dependent and organ-specific manner. ..