Seung U Kim

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. doi request reprint Stem cell-based cell therapy in neurological diseases: a review
    Seung U Kim
    Division of Neurology, Department of Medicine, UBC Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    J Neurosci Res 87:2183-200. 2009
  2. ncbi request reprint Microglia in health and disease
    Seung U Kim
    Division of Neurology, Department of Medicine, UBC Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    J Neurosci Res 81:302-13. 2005
  3. ncbi request reprint Immortalized human microglial cell line: phenotypic expression
    Atsushi Nagai
    Department of Neurology, Shimane University School of Medicine, Izumo, Japan
    J Neurosci Res 81:342-8. 2005
  4. pmc Transplantation of human neural stem cells transduced with Olig2 transcription factor improves locomotor recovery and enhances myelination in the white matter of rat spinal cord following contusive injury
    Dong H Hwang
    Brain Disease Research Center, Institute for Medical Sciences, Ajou University School of Medicine, Suwon, Korea
    BMC Neurosci 10:117. 2009
  5. doi request reprint Neural stem cell-based gene therapy for brain tumors
    Seung U Kim
    Division of Neurology, Department of Medicine, UBC Hospital, University of British Columbia, Vancouver, BC V6T 2B5, Canada
    Stem Cell Rev 7:130-40. 2011
  6. ncbi request reprint Brain transplantation of immortalized human neural stem cells promotes functional recovery in mouse intracerebral hemorrhage stroke model
    Hong J Lee
    Division of Neurology, Department of Medicine, University of British Columbia Hospital, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
    Stem Cells 25:1204-12. 2007
  7. doi request reprint Production and characterization of immortal human neural stem cell line with multipotent differentiation property
    Seung U Kim
    Division of Neurology, UBC Hospital, University of British Columbia, Vancouver, BC, Canada
    Methods Mol Biol 438:103-21. 2008
  8. ncbi request reprint Broad-spectrum effects of 4-aminopyridine to modulate amyloid beta1-42-induced cell signaling and functional responses in human microglia
    Sonia Franciosi
    Departments of Anesthesiology, University of British Columbia, Vancouver, British Columbia, Canada
    J Neurosci 26:11652-64. 2006
  9. pmc Midkine, heparin-binding growth factor, blocks kainic acid-induced seizure and neuronal cell death in mouse hippocampus
    Yun B Kim
    Division of Neurology, Department of Medicine, UBC Hospital, University of British Columbia, Vancouver, Canada
    BMC Neurosci 11:42. 2010
  10. ncbi request reprint Differential activation of subtype purinergic receptors modulates Ca(2+) mobilization and COX-2 in human microglia
    Hyun B Choi
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Glia 43:95-103. 2003

Collaborators

Detail Information

Publications73

  1. doi request reprint Stem cell-based cell therapy in neurological diseases: a review
    Seung U Kim
    Division of Neurology, Department of Medicine, UBC Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    J Neurosci Res 87:2183-200. 2009
    ..Steady and solid progress in stem cell research in both basic and preclinical settings should support the hope for development of stem cell-based cell therapies for neurological diseases...
  2. ncbi request reprint Microglia in health and disease
    Seung U Kim
    Division of Neurology, Department of Medicine, UBC Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    J Neurosci Res 81:302-13. 2005
    ..It is thus timely to review current status of knowledge on biology and immunology of microglia, and consider new directions of investigation on microglia in health and disease...
  3. ncbi request reprint Immortalized human microglial cell line: phenotypic expression
    Atsushi Nagai
    Department of Neurology, Shimane University School of Medicine, Izumo, Japan
    J Neurosci Res 81:342-8. 2005
    ..This immortalized microglia HMO6 cell line exhibits cell-type-specific antigens for microglia, including CD11b (Mac-1), CD68, CD86 (B7-2), HLA-ABC, HLA-DR, and RCA-1 lectin, and actively phagocytoses latex beads...
  4. pmc Transplantation of human neural stem cells transduced with Olig2 transcription factor improves locomotor recovery and enhances myelination in the white matter of rat spinal cord following contusive injury
    Dong H Hwang
    Brain Disease Research Center, Institute for Medical Sciences, Ajou University School of Medicine, Suwon, Korea
    BMC Neurosci 10:117. 2009
    ....
  5. doi request reprint Neural stem cell-based gene therapy for brain tumors
    Seung U Kim
    Division of Neurology, Department of Medicine, UBC Hospital, University of British Columbia, Vancouver, BC V6T 2B5, Canada
    Stem Cell Rev 7:130-40. 2011
    ....
  6. ncbi request reprint Brain transplantation of immortalized human neural stem cells promotes functional recovery in mouse intracerebral hemorrhage stroke model
    Hong J Lee
    Division of Neurology, Department of Medicine, University of British Columbia Hospital, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
    Stem Cells 25:1204-12. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  7. doi request reprint Production and characterization of immortal human neural stem cell line with multipotent differentiation property
    Seung U Kim
    Division of Neurology, UBC Hospital, University of British Columbia, Vancouver, BC, Canada
    Methods Mol Biol 438:103-21. 2008
    ....
  8. ncbi request reprint Broad-spectrum effects of 4-aminopyridine to modulate amyloid beta1-42-induced cell signaling and functional responses in human microglia
    Sonia Franciosi
    Departments of Anesthesiology, University of British Columbia, Vancouver, British Columbia, Canada
    J Neurosci 26:11652-64. 2006
    ..1) and intracellular signaling pathways in human microglia could serve as a therapeutic strategy for neuroprotection in Alzheimer's disease pathology...
  9. pmc Midkine, heparin-binding growth factor, blocks kainic acid-induced seizure and neuronal cell death in mouse hippocampus
    Yun B Kim
    Division of Neurology, Department of Medicine, UBC Hospital, University of British Columbia, Vancouver, Canada
    BMC Neurosci 11:42. 2010
    ..The present study was undertaken to investigate whether MK acts as an anticonvulsant in kainic acid (KA)-induced seizure in mouse and blocks KA-mediated neuronal cell death in hippocampus...
  10. ncbi request reprint Differential activation of subtype purinergic receptors modulates Ca(2+) mobilization and COX-2 in human microglia
    Hyun B Choi
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Glia 43:95-103. 2003
    ..These results suggest that modulation of subtypes of purinergic receptors regulates COX-2 in human microglia with a link involving SOC-mediated influx of Ca(2+)...
  11. pmc Human neural stem cells genetically modified to overexpress Akt1 provide neuroprotection and functional improvement in mouse stroke model
    Hong J Lee
    Department of Medicine, Division of Neurology, UBC Hospital, University of British Columbia, Vancouver, Canada
    PLoS ONE 4:e5586. 2009
    ..These results indicate that the F3.Akt1 human NSCs should be a great value as a cellular source for the cellular therapy in animal models of human neurological disorders including ICH...
  12. ncbi request reprint Mitochondrial ligand inhibits store-operated calcium influx and COX-2 production in human microglia
    Seok H Hong
    Department of Pharmacology and Therapeutics, Department of Medicine, University of British Columbia, Vancouver, Canada
    J Neurosci Res 83:1293-8. 2006
    ..These results suggest that activation of the PBR in mitochondria is linked to reduced entry of Ca2+ through plasmalemmal SOC and subsequent modulation of cellular functions in human microglia...
  13. pmc Multilineage potential of stable human mesenchymal stem cell line derived from fetal marrow
    Atsushi Nagai
    Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, Canada
    PLoS ONE 2:e1272. 2007
    ....
  14. ncbi request reprint Neuronal cell death induced by cystatin C in vivo and in cultured human CNS neurons is inhibited with cathepsin B
    Atsushi Nagai
    Department of Neurology, University of British Columbia, Vancouver, Canada
    Brain Res 1066:120-8. 2005
    ....
  15. ncbi request reprint IL-8 enhancement of amyloid-beta (Abeta 1-42)-induced expression and production of pro-inflammatory cytokines and COX-2 in cultured human microglia
    Sonia Franciosi
    Department of Pharmacology and Therapeutics, University of British Columbia, 2176 Health Sciences Mall, Vancouver, BC, Canada, V6T 1Z3
    J Neuroimmunol 159:66-74. 2005
    ..The actions of IL-8 to potentiate Abeta(1-42)-induced inflammatory mediators may have particular relevance to Alzheimer disease brain which exhibits elevated levels of the chemokine...
  16. ncbi request reprint Perturbations in calcium-mediated signal transduction in microglia from Alzheimer's disease patients
    James G McLarnon
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    J Neurosci Res 81:426-35. 2005
    ..Overall, these data indicate significant abnormalities are present in Ca2+-mediated signal transduction in microglia isolated from AD patients...
  17. ncbi request reprint Generation and characterization of human hybrid neurons produced between embryonic CNS neurons and neuroblastoma cells
    Atsushi Nagai
    Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, Canada
    Neurobiol Dis 11:184-98. 2002
    ..The present study indicates that the A1 human hybrid neuronal cell line should serve as a valuable in vitro model for studies of biology, physiology, and pathology of human neurons in health and disease...
  18. ncbi request reprint Minocycline inhibits neuronal death and glial activation induced by beta-amyloid peptide in rat hippocampus
    Jae K Ryu
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Glia 48:85-90. 2004
    ..The results from this study suggest that minocycline may have efficacy in the treatment of AD...
  19. ncbi request reprint Blockade of quinolinic acid-induced neurotoxicity by pyruvate is associated with inhibition of glial activation in a model of Huntington's disease
    Jae K Ryu
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada V6T 1Z3
    Exp Neurol 187:150-9. 2004
    ..These data suggest that pyruvate reduces oxidative free radical damage in QA-injected striatum and could have clinical utility in the treatment of Huntington's disease (HD)...
  20. ncbi request reprint Fractalkine and fractalkine receptors in human neurons and glial cells
    Kozo Hatori
    Division of Neurology, Department of Medicine, UBC Hospital, University of British Columbia, Vancouver, Canada
    J Neurosci Res 69:418-26. 2002
    ..These observations suggest that fractalkine released by injured neurons could induce proliferation, activation and/or migration of microglia at the injured brain sites...
  21. doi request reprint Expression of cytokines and cytokine receptors in human Schwann cells
    Akihiko Ozaki
    Division of Neurology, Department of Medicine, UBC Hospital, University of British Columbia, Vancouver, Canada
    Neuroreport 19:31-5. 2008
    ..The secreted cytokines may play a role in leukocyte recruitment and exacerbation of axonal injury process...
  22. ncbi request reprint Inhibition of lipopolysaccharide-induced cyclooxygenase-2, tumor necrosis factor-alpha and [Ca2+]i responses in human microglia by the peripheral benzodiazepine receptor ligand PK11195
    Hyan B Choi
    Department of Pharmacology and Therapeutics, Division of Neurology, Faculty of Medicine, The University of British Columbia, 2176 Health Sciences Mall, Vancouver, British Columbia, Canada V6T 1Z3
    J Neurochem 83:546-55. 2002
    ....
  23. ncbi request reprint Modulation of the purinergic P2X7 receptor attenuates lipopolysaccharide-mediated microglial activation and neuronal damage in inflamed brain
    Hyun B Choi
    Department of Anesthesiology, Pharmacology, and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada
    J Neurosci 27:4957-68. 2007
    ....
  24. ncbi request reprint Potential tumor-tropic effect of genetically engineered stem cells expressing suicide enzymes to selectively target invasive cancer in animal models
    Seung U Kim
    Department of Medicine, University of British Columbia Hospital Vancouver, BC, Canada
    Anticancer Res 31:1249-58. 2011
    ....
  25. ncbi request reprint Neuroprotective effects of pyruvate in the quinolinic acid rat model of Huntington's disease
    Jae K Ryu
    Department of Pharmacology and Therapeutics, Faculty of Medicine, The University of British Columbia, V6T 1Z3, Vancouver, BC, Canada
    Exp Neurol 183:700-4. 2003
    ..These results suggest that pyruvate may be effective in reducing neuronal damage in HD...
  26. ncbi request reprint Production of immortalized human neural crest stem cells
    Seung U Kim
    Division of Neurology, UBC Hospital, University of British Columbia, Vancouver, Canada
    Methods Mol Biol 198:55-65. 2002
  27. ncbi request reprint Cytokines, chemokines, and cytokine receptors in human microglia
    Yong B Lee
    Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, Canada
    J Neurosci Res 69:94-103. 2002
    ....
  28. ncbi request reprint Oligodendrocytes from human donors differ in resistance to herpes simplex virus 1 (HSV-1)
    Lorne F Kastrukoff
    Demyelinating Disease Study Group, Division of Neurology, University of British Columbia, Vancouver, British Columbia, Canada
    Glia 38:87-92. 2002
    ..Resistance to HSV-1, mediated by glial cells, is a nonimmune mechanism that may influence the development of acute CNS infection in man as well as individual susceptibility to this virus...
  29. doi request reprint Influence of the prodrugs 5-fluorocytosine and CPT-11 on ovarian cancer cells using genetically engineered stem cells: tumor-tropic potential and inhibition of ovarian cancer cell growth
    Ki Yon Kim
    Department of Obstetrics and Gynecology, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
    Cancer Sci 101:955-62. 2010
    ..F3.CD or HB1.F3.CE cells resulted in the inhibition of ovarian cancer cell growth. Based on the data presented herein, we suggest that GESTECs expressing CD/CE may have a potent advantage to selectively treat ovarian cancers...
  30. ncbi request reprint Amyloid beta peptide-induced corpus callosum damage and glial activation in vivo
    Nattinee Jantaratnotai
    Department of Pharmacology, The University of British Columbia, 2176 Health Sciences Mall, Vancouver, BC, Canada V6T 1Z3
    Neuroreport 14:1429-33. 2003
    ..Loss of function of cells in corpus callosum could provide a potential new model for the study of white matter damage in Alzheimer's disease...
  31. ncbi request reprint Interferon-gamma acutely induces calcium influx in human microglia
    Sonia Franciosi
    Department of Pharmacology, University of British Columbia, Vancouver, British Columbia, Canada
    J Neurosci Res 69:607-13. 2002
    ..The influx of Ca(2+) may serve a signaling role in microglia linking IFN-gamma to functional responses of the cells to infiltrating T lymphocytes into the central nervous system (CNS) during inflammatory processes...
  32. ncbi request reprint Human neural stem cells target experimental intracranial medulloblastoma and deliver a therapeutic gene leading to tumor regression
    Seung Ki Kim
    Department of Neurosurgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Clin Cancer Res 12:5550-6. 2006
    ....
  33. ncbi request reprint Regulation of human tyrosine hydroxylase gene by neuron-restrictive silencer factor
    Soo Min Kim
    Neuroscience Graduate Program, Ajou University School of Medicine, Suwon, Republic of Korea
    Biochem Biophys Res Commun 346:426-35. 2006
    ..Our data strongly suggest that NRSF/REST functions as a repressor of TH transcription in NSCs via a mechanism dependent on the TH NRSE/RE1 sites...
  34. ncbi request reprint Brain transplantation of human neural stem cells transduced with tyrosine hydroxylase and GTP cyclohydrolase 1 provides functional improvement in animal models of Parkinson disease
    Seung U Kim
    Brain Disease Research Center, Ajou University School of Medicine, Suwon, Korea
    Neuropathology 26:129-40. 2006
    ..These results indicate that human NSC, genetically transduced with TH and GTPCH1 genes, have great potential in clinical utility for cell replacement therapy in patients suffering from Parkinson disease...
  35. ncbi request reprint Granulocyte colony-stimulating factor stimulates neurogenesis via vascular endothelial growth factor with STAT activation
    Keun Hwa Jung
    Stroke and Neural Stem Cell Laboratory in Clinical Research Institute, Department of Neurology, Seoul National University Hospital, Seoul, South Korea
    Brain Res 1073:190-201. 2006
    ..G-CSF also activated endothelial cell proliferation in adult rat brain in vivo. Our results indicate that G-CSF stimulates neurogenesis through reciprocal interaction with VEGF and STAT activation...
  36. ncbi request reprint Transplantation of human neural stem cells exerts neuroprotection in a rat model of Parkinson's disease
    Takao Yasuhara
    Department of Neurology, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Neurosci 26:12497-511. 2006
    ..These results suggest that HB1.F3 cell transplantation exerts neuroprotective effects against dopaminergic depletion in vitro and in vivo because of trophic factor secretion and neuronal differentiation...
  37. ncbi request reprint Intravascular administration of tumor tropic neural progenitor cells permits targeted delivery of interferon-beta and restricts tumor growth in a murine model of disseminated neuroblastoma
    Paxton V Dickson
    Department of Surgery, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Pediatr Surg 42:48-53. 2007
    ..We investigated the potential of targeted delivery using tumor-tropic neural progenitor cells (NPCs) transduced to express human IFN-beta (hIFN-beta)...
  38. ncbi request reprint Transplantation of post-mitotic human neuroteratocarcinoma-overexpressing Nurr1 cells provides therapeutic benefits in experimental stroke: in vitro evidence of expedited neuronal differentiation and GDNF secretion
    Koichi Hara
    Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
    J Neurosci Res 85:1240-51. 2007
    ..Nurr1 cell grafts in ischemic stroke, with in vitro evidence suggesting the cells' excellent neuronal differentiation capability and ability to secrete GDNF as likely mechanisms mediating the observed therapeutic benefits...
  39. doi request reprint Transplantation of human neural stem cells protect against ischemia in a preventive mode via hypoxia-inducible factor-1alpha stabilization in the host brain
    Kon Chu
    Stroke and Neural Stem Cell Laboratory in Clinical Research Institute, Department of Neurology, Seoul National University Hospital, Seoul, South Korea
    Brain Res 1207:182-92. 2008
    ..These findings provide evidence that HIF-1alpha stabilization in human NSCs can be achieved effectively by DFX, and HIF-1alpha-stabilized NSCs protect against ischemia in a preventive mode...
  40. ncbi request reprint Intravenously transplanted human neural stem cells migrate to the injured spinal cord in adult mice in an SDF-1- and HGF-dependent manner
    Hiroki Takeuchi
    Department of Neurosurgery, Nagoya University School of Medicine, Nagoya, Japan
    Neurosci Lett 426:69-74. 2007
    ..Our study suggests that intravenously administered NSCs can be employed as a renewable source for replacing lost cells for the treatment of spinal cord injuries...
  41. pmc Activation of nicotinic acetylcholine receptor prevents the production of reactive oxygen species in fibrillar beta amyloid peptide (1-42)-stimulated microglia
    Ju Hyun Moon
    Neuroscience Graduate Program, Ajou University, School of Medicine, Suwon 443 721, Korea
    Exp Mol Med 40:11-8. 2008
    ....
  42. pmc Cross talk between P2 purinergic receptors modulates extracellular ATP-mediated interleukin-10 production in rat microglial cells
    Dong Reoyl Seo
    Neuroscience Graduate Program, Ajou University School of Medicine, Suwon 443 721, Korea
    Exp Mol Med 40:19-26. 2008
    ....
  43. pmc Behavioral improvement in a primate Parkinson's model is associated with multiple homeostatic effects of human neural stem cells
    D Eugene Redmond
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 104:12175-80. 2007
    ..We propose that multiple modes of reciprocal interaction between exogenous hNSCs and the pathological host milieu underlie the functional improvement observed in this model of PD...
  44. ncbi request reprint Upregulation of protease-activated receptor-1 in astrocytes in Parkinson disease: astrocyte-mediated neuroprotection through increased levels of glutathione peroxidase
    Yuri Ishida
    Department of Neurology and Department of Laboratory Medicine, Shimane University School of Medicine, Izumo, Japan
    J Neuropathol Exp Neurol 65:66-77. 2006
    ....
  45. ncbi request reprint Human neural stem cells improve sensorimotor deficits in the adult rat brain with experimental focal ischemia
    Kon Chu
    Department of Neurology, Stroke and Neural Stem Cell Laboratory in Clinical Research Institute, Seoul National University Hospital, Seoul National University, 28, Yongon Dong, Chongro Gu, Seoul 110 744, South Korea
    Brain Res 1016:145-53. 2004
    ..Our data suggest intravenously transplanted human NSCs can migrate and differentiate in the rat brain with focal ischemia and improve functional recovery...
  46. ncbi request reprint Amyloid beta peptide directly inhibits PKC activation
    Woojin Lee
    Department of Biology, College of Natural Sciences, Seoul National University, South Korea
    Mol Cell Neurosci 26:222-31. 2004
    ..These results suggest that Abeta peptides inhibit PKC activation via direct interactions, which may play a role in pathogenesis of AD...
  47. ncbi request reprint Proactive transplantation of human neural stem cells prevents degeneration of striatal neurons in a rat model of Huntington disease
    Jae K Ryu
    Brain Disease Research Center, Ajou University School of Medicine, Suwon, South Korea
    Neurobiol Dis 16:68-77. 2004
    ..The findings in this work have particular relevance to a rat model of HD in that proactive transplanted hNSCs protect host striatal neurons against neuronal injury and improve motor impairment induced by 3-NP toxicity...
  48. ncbi request reprint Roscovitine sensitizes glioma cells to TRAIL-mediated apoptosis by downregulation of survivin and XIAP
    Eun Hee Kim
    Institute for Medical Sciences, Ajou University School of Medicine, Suwon, South Korea
    Oncogene 23:446-56. 2004
    ..Taken together, these results suggest that downregulation of survivin and XIAP by subtoxic doses of roscovitine contributes to the amplification of caspase cascades, thereby overcoming glioma cell resistance to TRAIL-mediated apoptosis...
  49. ncbi request reprint Trisialoganglioside GT1b induces in vivo degeneration of nigral dopaminergic neurons: role of microglia
    Jae K Ryu
    Brain Disease Research Center, Ajou University School of Medicine, Suwon, South Korea
    Glia 38:15-23. 2002
    ....
  50. ncbi request reprint Lovastatin enhances Abeta production and senile plaque deposition in female Tg2576 mice
    In Ho Park
    Brain Disease Research Center, Ajou University School of Medicine, Suwon, South Korea
    Neurobiol Aging 24:637-43. 2003
    ..Our results suggest that low plasma cholesterol levels might be a risk factor for AD in females...
  51. ncbi request reprint Human neural stem cell transplantation promotes functional recovery in rats with experimental intracerebral hemorrhage
    Sang Wuk Jeong
    Department of Neurology, Ilsan Paik Hospital, Inje University, Ilsan, Korea
    Stroke 34:2258-63. 2003
    ..We hypothesize that intravenously transplanted human neural stem cells (NSCs) can migrate and differentiate into neurons or glial cells, thereby improving functional outcome in ICH...
  52. ncbi request reprint Thrombin-induced microglial activation produces degeneration of nigral dopaminergic neurons in vivo
    Sang H Choi
    Brain Disease Research Center, Neuroscience Graduate Program, Ajou University School of Medicine, Suwon 442 749, Korea
    J Neurosci 23:5877-86. 2003
    ....
  53. ncbi request reprint Sonic hedgehog and FGF8 collaborate to induce dopaminergic phenotypes in the Nurr1-overexpressing neural stem cell
    Tae Eun Kim
    Brain Disease Research Center, Ajou University School of Medicine, Suwon 442 749, Republic of Korea
    Biochem Biophys Res Commun 305:1040-8. 2003
    ....
  54. ncbi request reprint Human neural stem cells can migrate, differentiate, and integrate after intravenous transplantation in adult rats with transient forebrain ischemia
    Kon Chu
    Department of Neurology, Seoul National University Hospital, Seoul, South Korea
    Neurosci Lett 343:129-33. 2003
    ..Our findings show that transplanted human neural stem cells differentiate into mature neurons to replace lost neural cells in the adult hippocampus with human-rat neural chimeras...
  55. ncbi request reprint Adenosine triphosphate induces proliferation of human neural stem cells: Role of calcium and p70 ribosomal protein S6 kinase
    Jae K Ryu
    Brain Disease Research Center, Ajou University, Suwon, Korea
    J Neurosci Res 72:352-62. 2003
    ..The increase in NSC proliferation observed following ATP application can also be mediated by PI3-kinase-dependent p70 S6 kinase activation...
  56. ncbi request reprint Microglial activation and cell death induced by the mitochondrial toxin 3-nitropropionic acid: in vitro and in vivo studies
    Jae K Ryu
    Brain Disease Research Center, Ajou University School of Medicine, Suwon, Korea
    Neurobiol Dis 12:121-32. 2003
    ..The present results indicate that metabolic impairment in the CNS could involve both activation and cell death of microglia and contribute to pathology in neurodegenerative diseases...
  57. ncbi request reprint Phosphatidylinositol-3 kinase/Akt and GSK-3 mediated cytoprotective effect of epigallocatechin gallate on oxidative stress-injured neuronal-differentiated N18D3 cells
    Seong Ho Koh
    Department of Neurology, College of Medicine, Hanyang University, Seongdong Gu, Seoul 133 791, South Korea
    Neurotoxicology 25:793-802. 2004
    ..These results imply that EGCG has neuroprotective effect by increasing PI3K/Akt-dependent anti-apoptotic signals...
  58. ncbi request reprint ATP-induced in vivo neurotoxicity in the rat striatum via P2 receptors
    Jae K Ryu
    Brain Disease Research Center, Ajou University School of Medicine, Suwon 442 749, Korea
    Neuroreport 13:1611-5. 2002
    ....
  59. ncbi request reprint Intravenous administration of human neural stem cells induces functional recovery in Huntington's disease rat model
    Soon Tae Lee
    Department of Neurology, Clinical Research Institute, Seoul National University Hospital, 28, Yongon Dong, Chongro Gu, Seoul 110 744, South Korea
    Neurosci Res 52:243-9. 2005
    ....
  60. ncbi request reprint PEX-producing human neural stem cells inhibit tumor growth in a mouse glioma model
    Seung Ki Kim
    Department of Neurosurgery, Brigham and Women s Hospital and Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Clin Cancer Res 11:5965-70. 2005
    ..8%, P < 0.03) and proliferation (23.6%, P < 0.03). These results support the use of neural stem cells as delivery vehicle for targeting therapeutic genes against human glioma...
  61. ncbi request reprint Inhibition of thrombin-induced microglial activation and NADPH oxidase by minocycline protects dopaminergic neurons in the substantia nigra in vivo
    Sang H Choi
    Neuroscience Graduate Program and Brain Disease Research Center, Ajou University School of Medicine, Suwon, Korea
    J Neurochem 95:1755-65. 2005
    ..These results suggest that microglial NADPH oxidase may be a viable target for neuroprotection against oxidative damage...
  62. ncbi request reprint Effects of sabiporide, a specific Na+/H+ exchanger inhibitor, on neuronal cell death and brain ischemia
    Hye Seong Park
    Department of Physiology, School of Medicine, Ajou University, Suwon, Kyungkido 442 749, Republic of Korea
    Brain Res 1061:67-71. 2005
    ..In in vivo brain ischemia model, sabiporide produced protective effects, decreasing the infarct size and edema volume. Our results suggest that sabiporide elicits neuroprotective effect both in vitro and in vivo...
  63. ncbi request reprint Distribution and in situ proliferation patterns of intravenously injected immortalized human neural stem-like cells in rats with focal cerebral ischemia
    Kon Chu
    Department of Neurology, Clinical Research Institute, Seoul National University Hospital, 28 Yongon Dong, Chongro Gu, Seoul 110 744, South Korea
    Neurosci Res 50:459-65. 2004
    ..Our findings show that intravenously injected human neural stem-like cells may incorporate into the ischemic brain, and undergo proliferation responding to the endogenous mitotic signal during the acute period of focal ischemia...
  64. ncbi request reprint Noninvasive method of immortalized neural stem-like cell transplantation in an experimental model of Huntington's disease
    Soon Tae Lee
    Department of Neurology, Seoul National University Hospital, Neuroscience Research Institute of SNUMRC, 28 Yongondong, Chongnoku, Seoul 110 744, South Korea
    J Neurosci Methods 152:250-4. 2006
    ..This study shows that NSC migrate into the striatum, either from ventricle or from the systemic circulation, providing less invasive routes for stem cell application in HD...
  65. ncbi request reprint Human neural stem cells genetically modified for brain repair in neurological disorders
    Seung U Kim
    Brain Disease Research Center, Ajou University School of Medicine, Suwon, Korea
    Neuropathology 24:159-71. 2004
    ..There is further need for investigation into the neurogenic potential of the human bone marrow stem cell lines and their utility in animal models of neurological diseases...
  66. pmc Brain tumor tropism of transplanted human neural stem cells is induced by vascular endothelial growth factor
    Nils Ole Schmidt
    Neurosurgical Oncology Laboratory, Department of Neurosurgery, Brigham and Women s Hospital and Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neoplasia 7:623-9. 2005
    ..Our results indicate that tumor-upregulated VEGF and angiogenic-activated microvasculature are relevant guidance signals for NSC tropism toward brain tumors...
  67. pmc Human microglial cells synthesize albumin in brain
    Sung Min Ahn
    Center for Genomics and Proteomics, Lee Gil Ya Cancer and Diabetes Institute, Gachon University of Medicine and Science, Incheon, Korea
    PLoS ONE 3:e2829. 2008
    ..These data indicate that microglial cells may play a beneficial role in AD by secreting albumin that not only inhibits Abeta polymerization but also increases its clearance...
  68. doi request reprint Neural progenitor NT2N cell lines from teratocarcinoma for transplantation therapy in stroke
    Koichi Hara
    Department of Neurology and Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Prog Neurobiol 85:318-34. 2008
    ..Such highly potent neuronal lineage commitment and neurotrophic factor secretory function of NT2.Nurr1 cells make them an appealing graft source for transplantation therapy...
  69. ncbi request reprint Downregulation of GFAP, TSP-1, and p53 in human glioblastoma cell line, U373MG, by IE1 protein from human cytomegalovirus
    Karim Lee
    Institute of Molecular Biology and Genetics, Seoul National University, Seoul, Korea
    Glia 51:1-12. 2005
    ..Our data strongly suggested that HCMV IE1 could modulate the expression of cellular genes that might play important roles in the pathogenesis of glial tumors...
  70. doi request reprint Neuroprotective effect of neural stem cell-conditioned media in in vitro model of Huntington's disease
    Heon Chang Lim
    Department of Anatomay, College of Medicine, Seoul National University, Seoul, South Korea
    Neurosci Lett 435:175-80. 2008
    ..In summary, NSC-CM was neuroprotective in in vitro model of Huntington's disease with modulating mutant huntingtin-induced cytotoxicity...
  71. ncbi request reprint Transient receptor potential vanilloid subtype 1 mediates cell death of mesencephalic dopaminergic neurons in vivo and in vitro
    Sang R Kim
    Brain Disease Research Center, Ajou University School of Medicine, Suwon 442 749, Korea
    J Neurosci 25:662-71. 2005
    ..Our findings suggest that these two types of receptors, TRPV1 and CB1, may contribute to neurodegeneration in response to endogenous ligands such as AEA...
  72. ncbi request reprint Novel method for visualizing and modeling the spatial distribution of neural stem cells within intracranial glioma
    David Lin
    Division of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA 91010, USA
    Neuroimage 37:S18-26. 2007
    ..We estimate that NSC-mediated therapy would eradicate 70-90% of the primary tumor mass and the majority of invasive tumor foci. Our method may serve as a model for optimizing the efficacy of NSC-based glioma therapy...
  73. ncbi request reprint The free-radical scavenger edaravone restores the differentiation of human neural precursor cells after radiation-induced oxidative stress
    Jun Ishii
    Department of Biosciences, Teikyo University of Science and Technology, Uenohara, Yamanashi 409 0193, Japan
    Neurosci Lett 423:225-30. 2007
    ..Our study may shed some light on the beneficial effects of free-radical scavengers in impaired neurogenesis following cranial radiation therapy...