T J Kieffer

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. ncbi request reprint GIP or not GIP? That is the question
    Timothy J Kieffer
    Departments of Physiology and Surgery, 2146 Health Sciences Mall, University of British Columbia, Vancouver, BC V6T 1Z3, Canada
    Trends Pharmacol Sci 24:110-2. 2003
  2. doi request reprint Circulating miR-375 as a biomarker of β-cell death and diabetes in mice
    Suheda Erener
    Department of Cellular and Physiological Sciences, 2350 Health Science Mall, University of British Columbia, V6T 1Z3 Vancouver, British Columbia, Canada
    Endocrinology 154:603-8. 2013
  3. pmc Maturation of human embryonic stem cell-derived pancreatic progenitors into functional islets capable of treating pre-existing diabetes in mice
    Alireza Rezania
    BetaLogics Venture, Janssen Research and Development, LLC, Raritan, New Jersey, USA
    Diabetes 61:2016-29. 2012
  4. ncbi request reprint Gastro-intestinal hormones GIP and GLP-1
    T J Kieffer
    Department of Physiology, University of British Columbia, 2146 Health Sciences Mall, Vancouver, B C V6T 1Z3, Canada
    Ann Endocrinol (Paris) 65:13-21. 2004
  5. ncbi request reprint The enteroinsular axis in dipeptidyl peptidase IV-negative rats
    R A Pederson
    Department of Physiology, University of British Columbia, Vancouver, Canada
    Metabolism 45:1335-41. 1996
  6. doi request reprint Immunohistochemical characterisation of cells co-producing insulin and glucagon in the developing human pancreas
    M J Riedel
    Laboratory of Molecular and Cellular Medicine, Department of Cellular and Physiological Sciences, Life Sciences Institute, 2350 Health Sciences Mall, University of British Columbia, Vancouver, BC, Canada V6T 1Z3
    Diabetologia 55:372-81. 2012
  7. ncbi request reprint Glucose-dependent insulinotropic polypeptide as a regulator of beta cell function and fate
    R D Wideman
    Departments of Physiology and Surgery, University of British Columbia, Vancouver, B C V6T 1Z3, Canada
    Horm Metab Res 36:782-6. 2004
  8. doi request reprint The glucagon-like peptide-1 receptor agonist exenatide restores impaired pro-islet amyloid polypeptide processing in cultured human islets: implications in type 2 diabetes and islet transplantation
    Y J Park
    Department of Surgery, Faculty of Medicine, University of British Columbia, Jim Pattison Pavilion, Vancouver General Hospital, 910 W 10th Avenue, Vancouver, BC V5Z 4E3, Canada
    Diabetologia 56:508-19. 2013
  9. pmc Musashi expression in β-cells coordinates insulin expression, apoptosis and proliferation in response to endoplasmic reticulum stress in diabetes
    M Szabat
    Department of Cellular and Physiological Sciences, Life Sciences Institute, Vancouver, BC, Canada
    Cell Death Dis 2:e232. 2011
  10. ncbi request reprint Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats
    F C Lynn
    Department of Physiology, University of British Columbia, Vancouver, Canada
    Diabetes 50:1004-11. 2001

Collaborators

Detail Information

Publications48

  1. ncbi request reprint GIP or not GIP? That is the question
    Timothy J Kieffer
    Departments of Physiology and Surgery, 2146 Health Sciences Mall, University of British Columbia, Vancouver, BC V6T 1Z3, Canada
    Trends Pharmacol Sci 24:110-2. 2003
    ..However, a recent study using GIP receptor knockout mice suggests that inhibition of GIP signalling might be a new target for anti-obesity drugs...
  2. doi request reprint Circulating miR-375 as a biomarker of β-cell death and diabetes in mice
    Suheda Erener
    Department of Cellular and Physiological Sciences, 2350 Health Science Mall, University of British Columbia, V6T 1Z3 Vancouver, British Columbia, Canada
    Endocrinology 154:603-8. 2013
    ..These data suggest that circulating miR-375 can be used as a marker of β-cell death and potential predictor of diabetes...
  3. pmc Maturation of human embryonic stem cell-derived pancreatic progenitors into functional islets capable of treating pre-existing diabetes in mice
    Alireza Rezania
    BetaLogics Venture, Janssen Research and Development, LLC, Raritan, New Jersey, USA
    Diabetes 61:2016-29. 2012
    ..Our findings support the feasibility of using differentiated hESCs as an alternative to cadaveric islets for treating patients with diabetes...
  4. ncbi request reprint Gastro-intestinal hormones GIP and GLP-1
    T J Kieffer
    Department of Physiology, University of British Columbia, 2146 Health Sciences Mall, Vancouver, B C V6T 1Z3, Canada
    Ann Endocrinol (Paris) 65:13-21. 2004
  5. ncbi request reprint The enteroinsular axis in dipeptidyl peptidase IV-negative rats
    R A Pederson
    Department of Physiology, University of British Columbia, Vancouver, Canada
    Metabolism 45:1335-41. 1996
    ..An explanation of the lack of effect of the absence of DPIV on the GLP-1(7-36) response to oral glucose and insulinotropic action of this peptide must await further study...
  6. doi request reprint Immunohistochemical characterisation of cells co-producing insulin and glucagon in the developing human pancreas
    M J Riedel
    Laboratory of Molecular and Cellular Medicine, Department of Cellular and Physiological Sciences, Life Sciences Institute, 2350 Health Sciences Mall, University of British Columbia, Vancouver, BC, Canada V6T 1Z3
    Diabetologia 55:372-81. 2012
    ....
  7. ncbi request reprint Glucose-dependent insulinotropic polypeptide as a regulator of beta cell function and fate
    R D Wideman
    Departments of Physiology and Surgery, University of British Columbia, Vancouver, B C V6T 1Z3, Canada
    Horm Metab Res 36:782-6. 2004
    ..A better understanding of GIP's effects on the beta cell under normal and pathological conditions may facilitate the design of GIP derivatives for the treatment of metabolic disorders...
  8. doi request reprint The glucagon-like peptide-1 receptor agonist exenatide restores impaired pro-islet amyloid polypeptide processing in cultured human islets: implications in type 2 diabetes and islet transplantation
    Y J Park
    Department of Surgery, Faculty of Medicine, University of British Columbia, Jim Pattison Pavilion, Vancouver General Hospital, 910 W 10th Avenue, Vancouver, BC V5Z 4E3, Canada
    Diabetologia 56:508-19. 2013
    ....
  9. pmc Musashi expression in β-cells coordinates insulin expression, apoptosis and proliferation in response to endoplasmic reticulum stress in diabetes
    M Szabat
    Department of Cellular and Physiological Sciences, Life Sciences Institute, Vancouver, BC, Canada
    Cell Death Dis 2:e232. 2011
    ..Our data also suggest that Musashi is a novel link between ER stress and the compensatory β-cell proliferation and the loss of β-cell gene expression seen in specific phases of the progression to type 2 diabetes...
  10. ncbi request reprint Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats
    F C Lynn
    Department of Physiology, University of British Columbia, Vancouver, Canada
    Diabetes 50:1004-11. 2001
    ..These data suggest that the decreased effectiveness of GIP in the VDF rat and in type 2 diabetes may be a result of a decreased receptor expression in the islet...
  11. doi request reprint Hepatic leptin signalling and subdiaphragmatic vagal efferents are not required for leptin-induced increases of plasma IGF binding protein-2 (IGFBP-2) in ob/ob mice
    J Levi
    Department of Cellular and Physiological Sciences, Life Sciences Institute, 2350 Health Sciences Mall, University of British Columbia, Vancouver, BC, Canada V6T 1Z3
    Diabetologia 55:752-62. 2012
    ....
  12. doi request reprint Differences between amyloid toxicity in alpha and beta cells in human and mouse islets and the role of caspase-3
    E Law
    Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of British Columbia, 2146 East Mall, Vancouver, BC, V6T 1Z3, Canada
    Diabetologia 53:1415-27. 2010
    ....
  13. ncbi request reprint Isolation of a murine glucose-dependent insulinotropic polypeptide (GIP) cDNA from a tumor cell line (STC6-14) and quantification of glucose-induced increases in GIP mRNA
    P J Schieldrop
    Department of Physiology, University of British Columbia, Vancouver, Canada
    Biochim Biophys Acta 1308:111-3. 1996
    ..In the presence of a 5-mM glucose stimulus, 1 x 10(5) GIP cells were found to contain 3.9 +/- 0.59 amol of GIP mRNA while the same number of cells contained 11.6 +/- 1.4 amol when subjected to a high (25 mM) glucose stimulus...
  14. doi request reprint New aspects of an old drug: metformin as a glucagon-like peptide 1 (GLP-1) enhancer and sensitiser
    Y M Cho
    Laboratory of Molecular and Cellular Medicine, Department of Cellular and Physiological Sciences, 2350 Health Sciences Mall, Life Sciences Centre, University of British Columbia, Vancouver, BC, Canada
    Diabetologia 54:219-22. 2011
    ..These provocative findings by Maida et al. extend our understanding of the mechanism of action of metformin and provide further insights into the benefits of combining metformin with incretin-based drugs to combat diabetes...
  15. ncbi request reprint Effects of dipeptidyl peptidase IV on the satiety actions of peptide YY
    S Unniappan
    Laboratory of Cellular and Molecular Medicine, Departments of Cellular and Physiological Sciences and Surgery, Life Sciences Institute, 2350 Health Sciences Mall, University of British Columbia, Vancouver, BC, V6T 1Z3 Canada
    Diabetologia 49:1915-23. 2006
    ..We hypothesised that DP IV inhibition could attenuate the satiety actions of peptide YY (PYY) by altering the conversion of PYY(1-36) to PYY(3-36)...
  16. pmc Improving function and survival of pancreatic islets by endogenous production of glucagon-like peptide 1 (GLP-1)
    Rhonda D Wideman
    Laboratories of Molecular and Cellular Medicine, Departments of Cellular and Physiological Sciences and Surgery, Life Sciences Institute, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC, Canada
    Proc Natl Acad Sci U S A 103:13468-73. 2006
    ..These results demonstrate a unique strategy for liberating GLP-1 from directly within the target organ and highlight the potential for up-regulating islet GLP-1 production as a means of treating diabetes...
  17. ncbi request reprint The pancreatic beta cell is a key site for mediating the effects of leptin on glucose homeostasis
    Scott D Covey
    Laboratory of Molecular and Cellular Medicine, Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    Cell Metab 4:291-302. 2006
    ..These data suggest that defects in this adipoinsular axis could contribute to diabetes associated with obesity...
  18. doi request reprint Reprogramming gut and pancreas endocrine cells to treat diabetes
    E Tuduri
    Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada
    Diabetes Obes Metab 13:53-9. 2011
    ..Here we review several reports based on the reprogramming of pancreas and gut endocrine cells to treat diabetes...
  19. doi request reprint Exercise restores endothelial function independently of weight loss or hyperglycaemic status in db/db mice
    F Moien-Afshari
    Department of Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada
    Diabetologia 51:1327-37. 2008
    ....
  20. doi request reprint DsAAV8-mediated expression of glucagon-like peptide-1 in pancreatic beta-cells ameliorates streptozotocin-induced diabetes
    M J Riedel
    Laboratory of Molecular and Cellular Medicine, Departments of Cellular and Physiological Sciences and Surgery, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
    Gene Ther 17:171-80. 2010
    ..Results from this study indicate that expression and secretion of GLP-1 from beta-cells in vivo via DsAAV8 represents a novel therapeutic strategy for treatment of diabetes...
  21. doi request reprint Mining incretin hormone pathways for novel therapies
    Rhonda D Wideman
    Laboratory of Molecular and Cellular Medicine, Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada
    Trends Endocrinol Metab 20:280-6. 2009
    ..Here, we review these recent advances and outline the multiple strategies being pursued to exploit the potential therapeutic benefits of GIP and GLP-1...
  22. pmc Disruption of hepatic leptin signaling protects mice from age- and diet-related glucose intolerance
    Frank K Huynh
    Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
    Diabetes 59:3032-40. 2010
    ..Leptin has a profound influence on glucose metabolism, so we sought to determine if leptin may exert this effect in part through the liver...
  23. doi request reprint Ldlr-/- mice display decreased susceptibility to Western-type diet-induced obesity due to increased thermogenesis
    Ying Fai Ngai
    Department of Medical Genetics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
    Endocrinology 151:5226-36. 2010
    ..In addition to its known role in lipid transport, these results demonstrate the importance of the Ldlr in energy homeostasis and suggest a direct physiological link between altered lipid transport and energy balance...
  24. ncbi request reprint Ghrelin, peptide YY, glucose-dependent insulinotropic polypeptide, and hunger responses to a mixed meal in anorexic, obese, and control female adolescents
    Sue Stock
    Endocrinology and Diabetes Unit, Room K4 212, British Columbia s Children s Hospital, 4480 Oak Street, Vancouver, British Columbia V6H 3V4, Canada
    J Clin Endocrinol Metab 90:2161-8. 2005
    ..Ghrelin is unlikely to play a causal role in anorexia nervosa or obesity. The lower GIP observed in AN subjects despite a similar caloric intake may appropriately prevent an excessive insulin response in these patients...
  25. doi request reprint Glucose-dependent insulinotropic polypeptide is expressed in pancreatic islet alpha-cells and promotes insulin secretion
    Yukihiro Fujita
    Laboratory of Molecular and Cellular Medicine, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
    Gastroenterology 138:1966-75. 2010
    ..Interestingly, a subset of enteroendocrine cells express both GIP and GLP-1. We sought to determine whether GIP also might be co-expressed with proglucagon in pancreatic alpha-cells...
  26. pmc Transplantation of PC1/3-Expressing alpha-cells improves glucose handling and cold tolerance in leptin-resistant mice
    Rhonda D Wideman
    Laboratory of Molecular and Cellular Medicine, Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
    Mol Ther 17:191-8. 2009
    ....
  27. doi request reprint Metabolic effects of chronic obestatin infusion in rats
    Suraj Unniappan
    Department of Cellular, Life Sciences Centre, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
    Peptides 29:1354-61. 2008
    ..Moreover, obestatin did not bind to INS-1 beta-cells or HEK cells overexpressing GLP-1 receptors or displace GLP-1 binding to these cells. Our findings do not support the concept that obestatin is a hormone with metabolic actions...
  28. pmc Production of functional glucagon-secreting α-cells from human embryonic stem cells
    Alireza Rezania
    BetaLogics Venture, Centocor Research and Development, Skillman, New Jersey, USA
    Diabetes 60:239-47. 2011
    ..Here we describe an efficient differentiation protocol for the in vitro conversion of hES cells to functional glucagon-producing α- cells...
  29. doi request reprint Acute disruption of leptin signaling in vivo leads to increased insulin levels and insulin resistance
    Jasna Levi
    Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
    Endocrinology 152:3385-95. 2011
    ..Our findings indicate that alterations in insulin sensitivity occur before changes in the lean:lipid ratio and energy expenditure during the acute disruption of endogenous leptin signaling...
  30. pmc Leptin therapy reverses hyperglycemia in mice with streptozotocin-induced diabetes, independent of hepatic leptin signaling
    Heather C Denroche
    Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
    Diabetes 60:1414-23. 2011
    ..Thus we hypothesized that exogenous leptin administered to mice with streptozotocin (STZ)-induced diabetes reverses hyperglycemia through direct action on hepatocytes...
  31. doi request reprint Duodenal-jejunal bypass protects GK rats from {beta}-cell loss and aggravation of hyperglycemia and increases enteroendocrine cells coexpressing GIP and GLP-1
    Madeleine Speck
    Dept of Cellular and Physiological Sciences, Life Sciences Institute, Univ of British Columbia, 2350 Health Sciences Mall, Vancouver, BC, Canada V6T 1Z3
    Am J Physiol Endocrinol Metab 300:E923-32. 2011
    ....
  32. doi request reprint Hyperinsulinemia precedes insulin resistance in mice lacking pancreatic beta-cell leptin signaling
    Sarah L Gray
    Laboratory of Molecular and Cellular Medicine, Department of Cellular and Physiological Sciences, Life Sciences Institute, 2350 Health Sciences Mall, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
    Endocrinology 151:4178-86. 2010
    ..Therefore, pancreatic beta-cell leptin receptor-deficient mice may represent a model of obesity-associated insulin resistance that is initiated by hyperinsulinemia...
  33. doi request reprint Differential processing of pro-glucose-dependent insulinotropic polypeptide in gut
    Yukihiro Fujita
    Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, Canada
    Am J Physiol Gastrointest Liver Physiol 298:G608-14. 2010
    ..Amidated GIP(1-30) and GIP(1-42) have comparable potency at stimulating somatostatin release in the perfused mouse stomach. Therefore, GIP(1-30) represents a naturally occurring, biologically active form of GIP...
  34. ncbi request reprint A switch from prohormone convertase (PC)-2 to PC1/3 expression in transplanted alpha-cells is accompanied by differential processing of proglucagon and improved glucose homeostasis in mice
    Rhonda D Wideman
    Department of Cellular and Physiological Sciences, Laboratory of Molecular and Cellular Medicine, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
    Diabetes 56:2744-52. 2007
    ..We hypothesized that alteration of PC expression in alpha-cells might convert the alpha-cell from a hyperglycemia-promoting cell to one that would improve glucose homeostasis...
  35. doi request reprint Treatment of obesity and diabetes in mice by transplant of gut cells engineered to produce leptin
    Sarah N Oosman
    Laboratory of Molecular and Cellular Medicine, Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
    Mol Ther 16:1138-45. 2008
    ..These results indicate that gut cells can be modified to express leptin in an inducible manner and that the transplantation of these cells has a therapeutic effect in leptin-deficient mice, but not in mice fed on a HFD...
  36. doi request reprint Pax6 and Pdx1 are required for production of glucose-dependent insulinotropic polypeptide in proglucagon-expressing L cells
    Yukihiro Fujita
    Department of Cellular and Physiological Sciences, Univ of British Columbia, Vancouver, BC, Canada V6T 1Z3
    Am J Physiol Endocrinol Metab 295:E648-57. 2008
    ..Our findings indicate that concomitant expression of Pax6 and Pdx1 is important for GIP expression. Our results also suggest that the presence of Pdx1 defines whether GLP-1-expressing gastrointestinal L cells also coexpress GIP...
  37. doi request reprint Incretin release from gut is acutely enhanced by sugar but not by sweeteners in vivo
    Yukihiro Fujita
    Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada V6T 1Z3
    Am J Physiol Endocrinol Metab 296:E473-9. 2009
    ..Collectively, our findings do not support the concept that release of incretins from enteroendocrine cells is triggered by carbohydrates via a pathway identical to the sensation of "sweet taste" in the tongue...
  38. doi request reprint Engineered glucagon-like peptide-1-producing hepatocytes lower plasma glucose levels in mice
    Michael J Riedel
    Laboratory of Molecular and Cellular Medicine, Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada V6T 1Z3
    Am J Physiol Endocrinol Metab 296:E936-44. 2009
    ..The results from this study demonstrate that a gene therapy approach designed to induce GLP-1 production in hepatocytes may represent a novel strategy for long-term secretion of bioactive GLP-1 for the treatment of type 2 diabetes...
  39. doi request reprint Regulation of somatostatin release by adenosine in the mouse stomach
    Gary K Yang
    Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, Canada
    J Pharmacol Exp Ther 329:729-37. 2009
    ....
  40. ncbi request reprint Harnessing the gut to treat diabetes
    Yukihiro Fujita
    The Laboratory of Molecular and Cellular Medicine, Department of Physiology, University of British Columbia, Vancouver, BC, Canada V6T 1Z3
    Pediatr Diabetes 5:57-69. 2004
    ..Utilizing a patient's own gut cells to re-establish endogenous meal-regulated insulin secretion could represent an attractive approach to ultimately cure diabetes...
  41. pmc Leptin extends the anorectic effects of chronic PYY(3-36) administration in ad libitum-fed rats
    Suraj Unniappan
    Laboratory of Molecular and Cellular Medicine, Departments of Cellular and Physiological Sciences and Surgery, Life Sciences Institute, University of British Columbia, Vancouver, Canada
    Am J Physiol Regul Integr Comp Physiol 295:R51-8. 2008
    ....
  42. doi request reprint Treatment of diabetes by transplantation of drug-inducible insulin-producing gut cells
    Suraj Unniappan
    Laboratory of Molecular and Cellular Medicine, Department of Cellular and Physiological Sciences, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC, V6T 1Z3, Canada
    J Mol Med (Berl) 87:703-12. 2009
    ..These data support the notion that engineering regulatable insulin expression within a cell already equipped for regulated secretion may be efficacious for the treatment of insulin-dependent diabetes...
  43. doi request reprint Ontogeny of ghrelin, obestatin, preproghrelin, and prohormone convertases in rat pancreas and stomach
    Pallavi Walia
    Endocrinology and Diabetes Unit, British Columbia Children s Hospital, Vancouver, British Columbia, V6H 3V4, Canada
    Pediatr Res 65:39-44. 2009
    ..In pancreas, the colocalization of PC1/3 or PC2 in ghrelin positive cells points to a role for both PCs in preproghrelin processing...
  44. ncbi request reprint Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women
    Karen L Teff
    Monell Chemical Senses Center, University of Pennsylvania, Philadelphia 19104, USA
    J Clin Endocrinol Metab 89:2963-72. 2004
    ....
  45. ncbi request reprint Inhibition of preproinsulin gene expression by leptin induction of suppressor of cytokine signaling 3 in pancreatic beta-cells
    Katharina Laubner
    Division of Metabolism, Endocrinology, and Molecular Medicine, Medizinische Klinik und Poliklinik II, University of Wurzburg, Klinikstrasse 6 8, 97070 Wurzburg, Germany
    Diabetes 54:3410-7. 2005
    ....
  46. ncbi request reprint Glucose-dependent insulinotropic polypeptide is expressed in adult hippocampus and induces progenitor cell proliferation
    Jenny Nyberg
    The Arvid Carlsson Institute for Neuroscience at the Institute of Clinical Neuroscience, Goteborg University, Sahlgrenska University Hospital, 413 45 Goteborg, Sweden
    J Neurosci 25:1816-25. 2005
    ..This investigation demonstrates the presence of GIP in the brain for the first time and provides evidence for a regulatory function for GIP in progenitor cell proliferation...
  47. ncbi request reprint Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages
    Raewyn M Seaberg
    Department of Medical Genetics and Microbiology, University of Toronto, Toronto M5S 1A8, Canada
    Nat Biotechnol 22:1115-24. 2004
    ..These cells represent a previously unidentified adult intrinsic pancreatic precursor population and are a promising candidate for cell-based therapeutic strategies...
  48. ncbi request reprint Leptin increases hepatic insulin sensitivity and protein tyrosine phosphatase 1B expression
    Ni T Lam
    Departments of Medicine and Physiology, University of Alberta, Edmonton, Alberta, Canada
    Mol Endocrinol 18:1333-45. 2004
    ....