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Genomes and Genes | T J KiefferSummaryAffiliation: University of British Columbia Country: Canada Publications
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Publications
GIP or not GIP? That is the questionTimothy J Kieffer
Departments of Physiology and Surgery, 2146 Health Sciences Mall, University of British Columbia, Vancouver, BC V6T 1Z3, Canada
Trends Pharmacol Sci 24:110-2. 2003..However, a recent study using GIP receptor knockout mice suggests that inhibition of GIP signalling might be a new target for anti-obesity drugs...
Circulating miR-375 as a biomarker of β-cell death and diabetes in miceSuheda Erener
Department of Cellular and Physiological Sciences, 2350 Health Science Mall, University of British Columbia, V6T 1Z3 Vancouver, British Columbia, Canada
Endocrinology 154:603-8. 2013..These data suggest that circulating miR-375 can be used as a marker of β-cell death and potential predictor of diabetes...
Maturation of human embryonic stem cell-derived pancreatic progenitors into functional islets capable of treating pre-existing diabetes in miceAlireza Rezania
BetaLogics Venture, Janssen Research and Development, LLC, Raritan, New Jersey, USA
Diabetes 61:2016-29. 2012..Our findings support the feasibility of using differentiated hESCs as an alternative to cadaveric islets for treating patients with diabetes...- Gastro-intestinal hormones GIP and GLP-1T J Kieffer
Department of Physiology, University of British Columbia, 2146 Health Sciences Mall, Vancouver, B.C. V6T 1Z3, Canada
Ann Endocrinol (Paris) 65:13-21. 2004 - The enteroinsular axis in dipeptidyl peptidase IV-negative ratsR A Pederson
Department of Physiology, University of British Columbia, Vancouver, Canada
Metabolism 45:1335-41. 1996..An explanation of the lack of effect of the absence of DPIV on the GLP-1(7-36) response to oral glucose and insulinotropic action of this peptide must await further study... - Immunohistochemical characterisation of cells co-producing insulin and glucagon in the developing human pancreasM J Riedel
Laboratory of Molecular and Cellular Medicine, Department of Cellular and Physiological Sciences, Life Sciences Institute, 2350 Health Sciences Mall, University of British Columbia, Vancouver, BC, Canada V6T 1Z3
Diabetologia 55:372-81. 2012.... - Glucose-dependent insulinotropic polypeptide as a regulator of beta cell function and fateR D Wideman
Departments of Physiology and Surgery, University of British Columbia, Vancouver, B.C. V6T 1Z3, Canada
Horm Metab Res 36:782-6. 2004..A better understanding of GIP's effects on the beta cell under normal and pathological conditions may facilitate the design of GIP derivatives for the treatment of metabolic disorders... - Musashi expression in β-cells coordinates insulin expression, apoptosis and proliferation in response to endoplasmic reticulum stress in diabetesM Szabat
Department of Cellular and Physiological Sciences, Life Sciences Institute, Vancouver, BC, Canada
Cell Death Dis 2:e232. 2011..Our data also suggest that Musashi is a novel link between ER stress and the compensatory β-cell proliferation and the loss of β-cell gene expression seen in specific phases of the progression to type 2 diabetes... - Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker ratsF C Lynn
Department of Physiology, University of British Columbia, Vancouver, Canada
Diabetes 50:1004-11. 2001..These data suggest that the decreased effectiveness of GIP in the VDF rat and in type 2 diabetes may be a result of a decreased receptor expression in the islet... - Hepatic leptin signalling and subdiaphragmatic vagal efferents are not required for leptin-induced increases of plasma IGF binding protein-2 (IGFBP-2) in ob/ob miceJ Levi
Department of Cellular and Physiological Sciences, Life Sciences Institute, 2350 Health Sciences Mall, University of British Columbia, Vancouver, BC, Canada V6T 1Z3
Diabetologia 55:752-62. 2012.... - The glucagon-like peptide-1 receptor agonist exenatide restores impaired pro-islet amyloid polypeptide processing in cultured human islets: implications in type 2 diabetes and islet transplantationY J Park
Department of Surgery, Faculty of Medicine, University of British Columbia, Jim Pattison Pavilion, Vancouver General Hospital, 910 W 10th Avenue, Vancouver, BC V5Z 4E3, Canada
Diabetologia 56:508-19. 2013.... - Differences between amyloid toxicity in alpha and beta cells in human and mouse islets and the role of caspase-3E Law
Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of British Columbia, 2146 East Mall, Vancouver, BC, V6T 1Z3, Canada
Diabetologia 53:1415-27. 2010.... - Isolation of a murine glucose-dependent insulinotropic polypeptide (GIP) cDNA from a tumor cell line (STC6-14) and quantification of glucose-induced increases in GIP mRNAP J Schieldrop
Department of Physiology, University of British Columbia, Vancouver, Canada
Biochim Biophys Acta 1308:111-3. 1996..In the presence of a 5-mM glucose stimulus, 1 x 10(5) GIP cells were found to contain 3.9 +/- 0.59 amol of GIP mRNA while the same number of cells contained 11.6 +/- 1.4 amol when subjected to a high (25 mM) glucose stimulus... - New aspects of an old drug: metformin as a glucagon-like peptide 1 (GLP-1) enhancer and sensitiserY M Cho
Laboratory of Molecular and Cellular Medicine, Department of Cellular and Physiological Sciences, 2350 Health Sciences Mall, Life Sciences Centre, University of British Columbia, Vancouver, BC, Canada
Diabetologia 54:219-22. 2011..These provocative findings by Maida et al. extend our understanding of the mechanism of action of metformin and provide further insights into the benefits of combining metformin with incretin-based drugs to combat diabetes... - Effects of dipeptidyl peptidase IV on the satiety actions of peptide YYS Unniappan
Laboratory of Cellular and Molecular Medicine, Departments of Cellular and Physiological Sciences and Surgery, Life Sciences Institute, 2350 Health Sciences Mall, University of British Columbia, Vancouver, BC, V6T 1Z3 Canada
Diabetologia 49:1915-23. 2006..We hypothesised that DP IV inhibition could attenuate the satiety actions of peptide YY (PYY) by altering the conversion of PYY(1-36) to PYY(3-36)... - Improving function and survival of pancreatic islets by endogenous production of glucagon-like peptide 1 (GLP-1)Rhonda D Wideman
Laboratories of Molecular and Cellular Medicine, Departments of Cellular and Physiological Sciences and Surgery, Life Sciences Institute, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC, Canada
Proc Natl Acad Sci U S A 103:13468-73. 2006..These results demonstrate a unique strategy for liberating GLP-1 from directly within the target organ and highlight the potential for up-regulating islet GLP-1 production as a means of treating diabetes... - The pancreatic beta cell is a key site for mediating the effects of leptin on glucose homeostasisScott D Covey
Laboratory of Molecular and Cellular Medicine, Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
Cell Metab 4:291-302. 2006..These data suggest that defects in this adipoinsular axis could contribute to diabetes associated with obesity... - Reprogramming gut and pancreas endocrine cells to treat diabetesE Tuduri
Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada
Diabetes Obes Metab 13:53-9. 2011..Here we review several reports based on the reprogramming of pancreas and gut endocrine cells to treat diabetes... - Exercise restores endothelial function independently of weight loss or hyperglycaemic status in db/db miceF Moien-Afshari
Department of Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada
Diabetologia 51:1327-37. 2008.... - DsAAV8-mediated expression of glucagon-like peptide-1 in pancreatic beta-cells ameliorates streptozotocin-induced diabetesM J Riedel
Laboratory of Molecular and Cellular Medicine, Departments of Cellular and Physiological Sciences and Surgery, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
Gene Ther 17:171-80. 2010..Results from this study indicate that expression and secretion of GLP-1 from beta-cells in vivo via DsAAV8 represents a novel therapeutic strategy for treatment of diabetes... - Mining incretin hormone pathways for novel therapiesRhonda D Wideman
Laboratory of Molecular and Cellular Medicine, Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada
Trends Endocrinol Metab 20:280-6. 2009..Here, we review these recent advances and outline the multiple strategies being pursued to exploit the potential therapeutic benefits of GIP and GLP-1... - Disruption of hepatic leptin signaling protects mice from age- and diet-related glucose intoleranceFrank K Huynh
Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
Diabetes 59:3032-40. 2010..Leptin has a profound influence on glucose metabolism, so we sought to determine if leptin may exert this effect in part through the liver... - Ldlr-/- mice display decreased susceptibility to Western-type diet-induced obesity due to increased thermogenesisYing Fai Ngai
Department of Medical Genetics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
Endocrinology 151:5226-36. 2010..In addition to its known role in lipid transport, these results demonstrate the importance of the Ldlr in energy homeostasis and suggest a direct physiological link between altered lipid transport and energy balance... - Ghrelin, peptide YY, glucose-dependent insulinotropic polypeptide, and hunger responses to a mixed meal in anorexic, obese, and control female adolescentsSue Stock
Endocrinology and Diabetes Unit, Room K4-212, British Columbia's Children's Hospital, 4480 Oak Street, Vancouver, British Columbia V6H 3V4, Canada
J Clin Endocrinol Metab 90:2161-8. 2005..Ghrelin is unlikely to play a causal role in anorexia nervosa or obesity. The lower GIP observed in AN subjects despite a similar caloric intake may appropriately prevent an excessive insulin response in these patients... - Glucose-dependent insulinotropic polypeptide is expressed in pancreatic islet alpha-cells and promotes insulin secretionYukihiro Fujita
Laboratory of Molecular and Cellular Medicine, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
Gastroenterology 138:1966-75. 2010..Interestingly, a subset of enteroendocrine cells express both GIP and GLP-1. We sought to determine whether GIP also might be co-expressed with proglucagon in pancreatic alpha-cells... - Transplantation of PC1/3-Expressing alpha-cells improves glucose handling and cold tolerance in leptin-resistant miceRhonda D Wideman
Laboratory of Molecular and Cellular Medicine, Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
Mol Ther 17:191-8. 2009.... - Metabolic effects of chronic obestatin infusion in ratsSuraj Unniappan
Department of Cellular, Life Sciences Centre, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
Peptides 29:1354-61. 2008..Moreover, obestatin did not bind to INS-1 beta-cells or HEK cells overexpressing GLP-1 receptors or displace GLP-1 binding to these cells. Our findings do not support the concept that obestatin is a hormone with metabolic actions... - Production of functional glucagon-secreting α-cells from human embryonic stem cellsAlireza Rezania
BetaLogics Venture, Centocor Research and Development, Skillman, New Jersey, USA
Diabetes 60:239-47. 2011..Here we describe an efficient differentiation protocol for the in vitro conversion of hES cells to functional glucagon-producing α- cells... - Acute disruption of leptin signaling in vivo leads to increased insulin levels and insulin resistanceJasna Levi
Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
Endocrinology 152:3385-95. 2011..Our findings indicate that alterations in insulin sensitivity occur before changes in the lean:lipid ratio and energy expenditure during the acute disruption of endogenous leptin signaling... - Leptin therapy reverses hyperglycemia in mice with streptozotocin-induced diabetes, independent of hepatic leptin signalingHeather C Denroche
Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
Diabetes 60:1414-23. 2011..Thus we hypothesized that exogenous leptin administered to mice with streptozotocin (STZ)-induced diabetes reverses hyperglycemia through direct action on hepatocytes... - Duodenal-jejunal bypass protects GK rats from {beta}-cell loss and aggravation of hyperglycemia and increases enteroendocrine cells coexpressing GIP and GLP-1Madeleine Speck
Dept of Cellular and Physiological Sciences, Life Sciences Institute, Univ of British Columbia, 2350 Health Sciences Mall, Vancouver, BC, Canada V6T 1Z3
Am J Physiol Endocrinol Metab 300:E923-32. 2011.... - Hyperinsulinemia precedes insulin resistance in mice lacking pancreatic beta-cell leptin signalingSarah L Gray
Laboratory of Molecular and Cellular Medicine, Department of Cellular and Physiological Sciences, Life Sciences Institute, 2350 Health Sciences Mall, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
Endocrinology 151:4178-86. 2010..Therefore, pancreatic beta-cell leptin receptor-deficient mice may represent a model of obesity-associated insulin resistance that is initiated by hyperinsulinemia... - Differential processing of pro-glucose-dependent insulinotropic polypeptide in gutYukihiro Fujita
Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, Canada
Am J Physiol Gastrointest Liver Physiol 298:G608-14. 2010..Amidated GIP(1-30) and GIP(1-42) have comparable potency at stimulating somatostatin release in the perfused mouse stomach. Therefore, GIP(1-30) represents a naturally occurring, biologically active form of GIP... - A switch from prohormone convertase (PC)-2 to PC1/3 expression in transplanted alpha-cells is accompanied by differential processing of proglucagon and improved glucose homeostasis in miceRhonda D Wideman
Department of Cellular and Physiological Sciences, Laboratory of Molecular and Cellular Medicine, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
Diabetes 56:2744-52. 2007..We hypothesized that alteration of PC expression in alpha-cells might convert the alpha-cell from a hyperglycemia-promoting cell to one that would improve glucose homeostasis... - Treatment of obesity and diabetes in mice by transplant of gut cells engineered to produce leptinSarah N Oosman
Laboratory of Molecular and Cellular Medicine, Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
Mol Ther 16:1138-45. 2008..These results indicate that gut cells can be modified to express leptin in an inducible manner and that the transplantation of these cells has a therapeutic effect in leptin-deficient mice, but not in mice fed on a HFD... - Pax6 and Pdx1 are required for production of glucose-dependent insulinotropic polypeptide in proglucagon-expressing L cellsYukihiro Fujita
Department of Cellular and Physiological Sciences, Univ of British Columbia, Vancouver, BC, Canada V6T 1Z3
Am J Physiol Endocrinol Metab 295:E648-57. 2008..Our findings indicate that concomitant expression of Pax6 and Pdx1 is important for GIP expression. Our results also suggest that the presence of Pdx1 defines whether GLP-1-expressing gastrointestinal L cells also coexpress GIP... - Incretin release from gut is acutely enhanced by sugar but not by sweeteners in vivoYukihiro Fujita
Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada V6T 1Z3
Am J Physiol Endocrinol Metab 296:E473-9. 2009..Collectively, our findings do not support the concept that release of incretins from enteroendocrine cells is triggered by carbohydrates via a pathway identical to the sensation of "sweet taste" in the tongue... - Engineered glucagon-like peptide-1-producing hepatocytes lower plasma glucose levels in miceMichael J Riedel
Laboratory of Molecular and Cellular Medicine, Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada V6T 1Z3
Am J Physiol Endocrinol Metab 296:E936-44. 2009..The results from this study demonstrate that a gene therapy approach designed to induce GLP-1 production in hepatocytes may represent a novel strategy for long-term secretion of bioactive GLP-1 for the treatment of type 2 diabetes... - Regulation of somatostatin release by adenosine in the mouse stomachGary K Yang
Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, Canada
J Pharmacol Exp Ther 329:729-37. 2009.... - Harnessing the gut to treat diabetesYukihiro Fujita
The Laboratory of Molecular and Cellular Medicine, Department of Physiology, University of British Columbia, Vancouver, BC, Canada V6T 1Z3
Pediatr Diabetes 5:57-69. 2004..Utilizing a patient's own gut cells to re-establish endogenous meal-regulated insulin secretion could represent an attractive approach to ultimately cure diabetes... - Leptin extends the anorectic effects of chronic PYY(3-36) administration in ad libitum-fed ratsSuraj Unniappan
Laboratory of Molecular and Cellular Medicine, Departments of Cellular and Physiological Sciences and Surgery, Life Sciences Institute, University of British Columbia, Vancouver, Canada
Am J Physiol Regul Integr Comp Physiol 295:R51-8. 2008.... - Treatment of diabetes by transplantation of drug-inducible insulin-producing gut cellsSuraj Unniappan
Laboratory of Molecular and Cellular Medicine, Department of Cellular and Physiological Sciences, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC, V6T 1Z3, Canada
J Mol Med (Berl) 87:703-12. 2009..These data support the notion that engineering regulatable insulin expression within a cell already equipped for regulated secretion may be efficacious for the treatment of insulin-dependent diabetes... - Ontogeny of ghrelin, obestatin, preproghrelin, and prohormone convertases in rat pancreas and stomachPallavi Walia
Endocrinology and Diabetes Unit, British Columbia Children s Hospital, Vancouver, British Columbia, V6H 3V4, Canada
Pediatr Res 65:39-44. 2009..In pancreas, the colocalization of PC1/3 or PC2 in ghrelin positive cells points to a role for both PCs in preproghrelin processing... - Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in womenKaren L Teff
Monell Chemical Senses Center, University of Pennsylvania, Philadelphia 19104, USA
J Clin Endocrinol Metab 89:2963-72. 2004.... - Inhibition of preproinsulin gene expression by leptin induction of suppressor of cytokine signaling 3 in pancreatic beta-cellsKatharina Laubner
Division of Metabolism, Endocrinology, and Molecular Medicine, Medizinische Klinik und Poliklinik II, University of Wurzburg, Klinikstrasse 6 8, 97070 Wurzburg, Germany
Diabetes 54:3410-7. 2005.... - Glucose-dependent insulinotropic polypeptide is expressed in adult hippocampus and induces progenitor cell proliferationJenny Nyberg
The Arvid Carlsson Institute for Neuroscience at the Institute of Clinical Neuroscience, Goteborg University, Sahlgrenska University Hospital, 413 45 Goteborg, Sweden
J Neurosci 25:1816-25. 2005..This investigation demonstrates the presence of GIP in the brain for the first time and provides evidence for a regulatory function for GIP in progenitor cell proliferation... - Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineagesRaewyn M Seaberg
Department of Medical Genetics and Microbiology, University of Toronto, Toronto M5S 1A8, Canada
Nat Biotechnol 22:1115-24. 2004..These cells represent a previously unidentified adult intrinsic pancreatic precursor population and are a promising candidate for cell-based therapeutic strategies... - Leptin increases hepatic insulin sensitivity and protein tyrosine phosphatase 1B expressionNi T Lam
Departments of Medicine and Physiology, University of Alberta, Edmonton, Alberta, Canada
Mol Endocrinol 18:1333-45. 2004....