Research Topics
| K M KhanSummaryAffiliation: University of British Columbia Country: Canada Publications
| Collaborators
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Detail Information
Publications
Overuse tendinosis, not tendinitis part 1: a new paradigm for a difficult clinical problemK M Khan
Allan McGavin Sports Medicine Centre, University of British Columbia, Vancouver, BC, V6T 1Z1, Can
Phys Sportsmed 28:38-48. 2000..These include adaptation of advice given when counseling, interaction with the physical therapist and athletic trainer, interpretation of imaging, choice of conservative management, and consideration of whether surgery is an option...- Histopathology of common tendinopathies. Update and implications for clinical managementK M Khan
School of Human Kinetics, University of British Columbia, Vancouver, Canada
Sports Med 27:393-408. 1999..We conclude that effective treatment of athletes with tendinopathies must target the most common underlying histopathology, tendinosis, a noninflammatory condition... 
New criteria for female athlete triad syndrome? As osteoporosis is rare, should osteopenia be among the criteria for defining the female athlete triad syndrome?K M Khan
Department of Family Practice, University of British Columbia, Vancouver, Canada
Br J Sports Med 36:10-3. 2002- Are ultrasound and magnetic resonance imaging of value in assessment of Achilles tendon disorders? A two year prospective studyK M Khan
Department of Family Practice, University of British Columbia, Vancouver, BC, Canada
Br J Sports Med 37:149-53. 2003.... 
Does a novel school-based physical activity model benefit femoral neck bone strength in pre- and early pubertal children?H M Macdonald
Department of Orthopaedics, University of British Columbia, 302 2647 Willow St, Vancouver, BC, Canada, V5Z 3P1
Osteoporos Int 19:1445-56. 2008..Our intervention also enhanced bone mass accrual by 2-4% at the lumbar spine and total body in boys...- A school-based exercise intervention augments bone mineral accrual in early pubertal girlsK J MacKelvie
School of Human Kinetics, University of British Columbia, Vancouver, Canada
J Pediatr 139:501-8. 2001..05); gain at other sites did not differ. CONCLUSIONS: In girls, early puberty may be a particularly opportune time during growth for simple exercise interventions to have a positive effect on bone health... - Lifestyle risk factors for osteoporosis in Asian and Caucasian girlsK J MacKelvie
School of Human Kinetics, University of British Columbia, Vancouver, BC, Canada
Med Sci Sports Exerc 33:1818-24. 2001..CONCLUSION: Thus, there was greater ethnic disparity in lifestyle factors related to bone health and absolute measures of bone mineral with advanced maturity... - Results of a 10 week community based strength and balance training programme to reduce fall risk factors: a randomised controlled trial in 65-75 year old women with osteoporosisN D Carter
BC Women's Hospital and Health Centre Osteoporosis Program and Faculty of Medicine, University of British Columbia, Vancouver, Canada
Br J Sports Med 35:348-51. 2001..However, trends toward improvement in key independent risk factors for falling suggest that a study with greater power may show that these variables can be improved to a level that reaches statistical significance... - Increased versican content is associated with tendinosis pathology in the patellar tendon of athletes with jumper's kneeA Scott
Department of Medicine, University of British Columbia, Vancouver, BC, Canada
Scand J Med Sci Sports 18:427-35. 2008.... - Hand dominance and bone response after a distal radial fracture: a peripheral QCT studyM C Ashe
University of British Columbia, Vancouver, British Columbia, Canada
J Clin Densitom 10:93-101. 2007..This cross-sectional study suggests that the bone response to a nondominant fracture may differ from a dominant fracture... - Muscle power is related to tibial bone strength in older womenM C Ashe
Centre for Hip Health and Mobility, Vancouver, BC, Canada
Osteoporos Int 19:1725-32. 2008..9% in the section modulus after accounting for age, height, weight, and physical activity; moderate to vigorous physical activity was related to muscle power in the lower extremity... - "Bounce at the Bell": a novel program of short bouts of exercise improves proximal femur bone mass in early pubertal childrenH A McKay
University of British Columbia, 588 828 West 10th Ave, Vancouver, BC, V52 1L8, Canada
Br J Sports Med 39:521-6. 2005..To examine the effects of a simple and inexpensive physical activity intervention on change in bone mass and structure in school aged children... - Economic evaluation of dose-response resistance training in older women: a cost-effectiveness and cost-utility analysisJ C Davis
Centre for Hip Health and Mobility, University of British Columbia, Vancouver, Canada
Osteoporos Int 22:1355-66. 2011..Both resistance training interventions were more likely to save health care resource money and offer better health outcomes for falls prevention than balance and tone classes... - Bone geometric response to chronic disuse following stroke: a pQCT studyM C Ashe
Department of Family Practice, University of British Columbia, Vancouver, British Columbia, Canada V6T 1V6
J Musculoskelet Neuronal Interact 6:226-33. 2006..The objectives of this study were to 1) assess volumetric bone geometry and density at the distal radius of individuals with chronic stroke and 2) assess whether bone strength is associated with measures of muscle strength and impairment... - SF-6D and EQ-5D result in widely divergent incremental cost-effectiveness ratios in a clinical trial of older women: implications for health policy decisionsJ C Davis
Centre for Clinical Epidemiology and Evaluation, VCH Research Institute, The University of British Columbia, Research Pavilion, 7th Floor, 828 West 10th Avenue, Vancouver, BC, V5Z 1M9, Canada
Osteoporos Int 23:1849-57. 2012..We found that the incremental QALYs estimated from the SF-6D were two- to threefold greater than those estimated from the EQ-5D... - Does a home-based strength and balance programme in people aged > or =80 years provide the best value for money to prevent falls? A systematic review of economic evaluations of falls prevention interventionsJ C Davis
Centre for Hip Health and Mobility, University of British Columbia and Vancouver Coastal Health Research Institute, Vancouver, Canada
Br J Sports Med 44:80-9. 2010..To investigate the value for money of strategies to prevent falls in older adults living in the community... - International comparison of cost of falls in older adults living in the community: a systematic reviewJ C Davis
Centre for Hip Health and Mobility, University of British Columbia, Vancouver, Canada
Osteoporos Int 21:1295-306. 2010..Our systematic review emphasized the need for a consensus on methodology for cost of falls studies to enable more accurate comparisons and subgroup-specific estimates among different countries... - Muscle cross-sectional area is associated with specific site of bone in prepubertal girls: a quantitative magnetic resonance imaging studyA Heinonen
School of Human Kinetics, University of British Columbia, Vancouver, Canada
Bone 29:388-92. 2001..This relationship was present in a regional, site-specific fashion... - Exercise in the prevention of falls in older people: a systematic literature review examining the rationale and the evidenceN D Carter
Department of Family Practice, University of British Columbia, Vancouver, Canada
Sports Med 31:427-38. 2001..Further investigation, using trials designed with the current limitations in mind, is necessary to establish the optimum exercise programme to maximise fall prevention in older adults... - High strain mechanical loading rapidly induces tendon apoptosis: an ex vivo rat tibialis anterior modelA Scott
Department of Family Practice and School of Human Kinetics, University of British Columbia, Vancouver, Canada
Br J Sports Med 39:e25. 2005..This is the first report of mechanical loading of intact tendon causing excessive apoptosis... - Community-dwelling seniors who present to the emergency department with a fall do not receive Guideline care and their fall risk profile worsens significantly: a 6-month prospective studyA E Salter
UBC Bone Health Research Group, Centre for Hip Health, Department of Orthopaedics, University of British Columbia and Vancouver Coastal Health Research Institute, Vancouver, B.C, Canada
Osteoporos Int 17:672-83. 2006..5%. This gap in care, at least in one centre, suggests further investigation into alternative approaches to delivering Guideline standard health service... - Accuracy of pQCT for evaluating the aged human radius: an ashing, histomorphometry and failure load investigationM C Ashe
Department of Family Practice, University of British Columbia, Suite 320 5950 University Blvd, Vancouver, British Columbia, Canada, V6T 1Z3
Osteoporos Int 17:1241-51. 2006..However, in a compromised osteoporotic bone, thin cortices and low scan resolution can limit accurate analysis... - What do we mean by the term "inflammation"? A contemporary basic science update for sports medicineA Scott
University of British Columbia, Vancouver, Canada
Br J Sports Med 38:372-80. 2004.... - Increased mast cell numbers in human patellar tendinosis: correlation with symptom duration and vascular hyperplasiaA Scott
Department of Medicine, University of British Columbia, Vancouver, Canada
Br J Sports Med 42:753-7. 2008..It has been suggested that because of the close anatomical associations between mast cells and vessels in connective tissues, mast cells may mediate the development of tendon hypervascularity or oedema... - Change in lean body mass is a major determinant of change in areal bone mineral density of the proximal femur: a 12-year observational studyT Liu-Ambrose
UBC Bone Health Research Group: Centre for Hip Health, BC Women's Hospital and Health Centre Osteoporosis Program, and Faculty of Medicine, University of British Columbia, 828 West 10th Avenue, Vancouver, BC, Canada, V5Z 1L8
Calcif Tissue Int 79:145-51. 2006..These novel longitudinal data highlight the important contribution of LBM to the maintenance of proximal femur bone mass at a key time in women's life span, the years surrounding menopause... - The VISA-A questionnaire: a valid and reliable index of the clinical severity of Achilles tendinopathyJ M Robinson
Department of Family Practice, University of British Columbia, Vancouver, Canada
Br J Sports Med 35:335-41. 2001..The test is not designed to be diagnostic. Further studies are needed to determine whether the VISA-A score predicts prognosis... - Exercise interventions for health: time to focus on dimensions, delivery, and dollarsH A McKay
School of Human Kinetics, University of British Columbia, Vancouver, BC V6T 1Z1, Canada
Br J Sports Med 37:98-9. 2003 - Is there a critical period for bone response to weight-bearing exercise in children and adolescents? a systematic reviewK J MacKelvie
School of Human Kinetics, University of British Columbia, 6081 University Boulevard, Vancouver, BC V6T 1Z1, Canada
Br J Sports Med 36:250-7; discussion 257. 2002..The effects of hormonal factors and growth on bone mineral change during puberty are examined, and the possibility of a critical period during which bone is especially adaptable to exercise is discussed... - The cost of fall related presentations to the ED: a prospective, in-person, patient-tracking analysis of health resource utilizationJ C Woolcott
Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada
Osteoporos Int 23:1513-9. 2012..Using data collected on 102 falls, we found the average cost per fall causing an Emergency Department presentation of $11,408. When hospitalization was required, the average cost per fall was $29,363... - A randomized school-based jumping intervention confers site and maturity-specific benefits on bone structural properties in girls: a hip structural analysis studyM A Petit
School of Human Kinetics, University of British Columbia, Vancouver, Canada
J Bone Miner Res 17:363-72. 2002..0%, p = 0.04), but not at the IT region. There were no differences at the primarily cortical FS. These data provide insight into geometric changes that underpin exercise-associated gain in bone strength in early-pubertal girls... - Bone mineral response to a 7-month randomized controlled, school-based jumping intervention in 121 prepubertal boys: associations with ethnicity and body mass indexK J MacKelvie
School of Human Kinetics, University of British Columbia, Vancouver, Canada
J Bone Miner Res 17:834-44. 2002..In summary, jumping exercise augmented bone mineral accrual at several regions equally in prepubertal Asian and white boys of average or low BMI, and intervention effects on bone mineral were undetectable in high BMI prepubertal boys... - Mechanotherapy: how physical therapists' prescription of exercise promotes tissue repairK M Khan
Centre for Hip Health and Mobility and Department of Family Practice, University of British Columbia, Vancouver, Canada
Br J Sports Med 43:247-52. 2009..After first outlining the process of mechanotransduction, we provide well-known clinical therapeutic examples of mechanotherapy-turning movement into tissue healing... - The de morton mobility index: normative data for a clinically useful mobility instrumentE M Macri
Centre for Hip Health and Mobility, University of British Columbia, Vancouver, BC, Canada V5Z 1M9
J Aging Res 2012:353252. 2012..49) or reported falls history (P = 0.21). Normative data for the DEMMI mobility instrument provides vital reference scores to facilitate its use across the mobility spectrum in clinical, research, and policymaking settings... - Body position affects performance in untrained cyclistsM C Ashe
University of British Columbia, Vancouver, BC, Canada
Br J Sports Med 37:441-4. 2003..To compare cardiovascular and ventilatory variables in upright versus aero cycle ergometry at submaximal and maximal exercise intensities in untrained cyclists... - Ground reaction forces associated with an effective elementary school based jumping interventionH McKay
Department of Family Practice and Orthopaedics, Faculty of Medicine, University of British Columbia, Vancouver, Canada
Br J Sports Med 39:10-4. 2005..Ground reaction forces (GRFs) may provide a surrogate measure for the strain experienced by bone on landing and at take off. However, there appear to be no paediatric studies that assess GRFs across a variety of loading activities... - Balance confidence improves with resistance or agility training. Increase is not correlated with objective changes in fall risk and physical abilitiesT Liu-Ambrose
School of Human Kinetics, University of British Columbia, Vancouver, Canada
Gerontology 50:373-82. 2004..Objective changes in fall risk factors cannot be assumed to mirror change in fear of falling and physical abilities in older adults in the short-term... - What is "inflammation"? Are we ready to move beyond Celsus?A Scott
University of British Columbia, Vancouver, Canada
Br J Sports Med 38:248-9. 2004 - The effects of proprioceptive or strength training on the neuromuscular function of the ACL reconstructed knee: a randomized clinical trialT Liu-Ambrose
School of Human Kinetics, University of British Columbia, Canada
Scand J Med Sci Sports 13:115-23. 2003..Proprioceptive training alone can induce isokinetic strength gains. Restoring and increasing quadriceps strength is essential to maximize functional ability of the operated knee joint... - The influence of back pain on balance and functional mobility in 65- to 75-year-old women with osteoporosisT Liu-Ambrose
Fall-Free BC Research Group, BC Women's Hospital, University of British Columbia, Vancouver, Canada
Osteoporos Int 13:868-73. 2002..Prospective studies are needed to determine whether pain management will improve balance and functional mobility... - Effect of nutrition and body composition on bone density after liver transplantationK M Khan
Department of Pediatrics University of Minnesota, Minneapolis, Minnesota 55455, USA
Transplant Proc 39:3292-4. 2007..We investigated the relationship between nutrition, body composition, and bone mineral density (BMD) in young adults after liver transplantation... - Dancing for bone health: a 3-year longitudinal study of bone mineral accrual across puberty in female non-elite dancers and controlsB L Matthews
Centre for Health, Exercise and Sports Medicine School of Physiotherapy, The University of Melbourne, Melbourne, Victoria 3010, Australia
Osteoporos Int 17:1043-54. 2006..However, the window of opportunity for optimizing positive effects of exercise on peak bone mass remains to be fully defined. Ballet dancing provides a model of mechanical loading patterns required to site-specifically modulate bone... - Abnormal tenocyte morphology is more prevalent than collagen disruption in asymptomatic athletes' patellar tendonsJ L Cook
Musculoskeletal Research Centre, La Trobe University, Victoria 3086, Australia
J Orthop Res 22:334-8. 2004..No tendons demonstrated neovascularization. It appears that cellular changes must be present if there is an increase in ground substance, or collagen and vascular changes. Further research is required to confirm these findings... - Outcome of surgery for chronic Achilles tendinopathy. A critical reviewC Tallon
Department of Orthopaedic Surgery, University of Aberdeen Medical School, Scotland
Am J Sports Med 29:315-20. 2001..01). Study methods may influence reported surgical outcome, and we suggest guidelines for improving study design in this area of clinical research. We acknowledge that study methods have improved over the course of the past 20 years... - Epidural abscess and vertebral osteomyelitis caused by Listeria monocytogenes: case report and literature reviewK M Khan
Department of Internal Medicine, New York Presbyterian Hospital-Weill Cornell Medical Center, NY 10021, USA
Scand J Infect Dis 33:714-6. 2001..To our knowledge, no cases of epidural abscess and only 3 cases of osteomyelitis have previously been reported in association with this organism... - Role of laminin in matrix induction of macrophage urokinase-type plasminogen activator and 92-kDa metalloproteinase expressionK M Khan
Department of Pathology, Cornell University Medical College, New York, New York 10021, USA
J Biol Chem 272:8270-5. 1997..These results demonstrate that macrophage binding to laminin plays an important role in the regulation of their degradative phenotype via the up-regulation of uPA and MMP-9... - Achilles tendinopathyJ L Cook
Musculoskeletal Research Centre, La Trobe University, Victoria, Australia
Man Ther 7:121-30. 2002..Surgical treatment is effective after complete tendon rupture, but may not assist recovery from overuse tendinopathy. Further research into the clinical aspects of Achilles tendinopathy is required... - Risk factors associated with exertional medial tibial pain: a 12 month prospective clinical studyS G Burne
University of NSW, Birchgrove, New South Wales, Australia
Br J Sports Med 38:441-5. 2004..To investigate in a military setting the potential role of intrinsic biomechanical and anthropometric risk factors for, and the incidence of, exertional medial tibial pain (EMTP)... - International Olympic Committee consensus statement: molecular basis of connective tissue and muscle injuries in sportArne Ljungqvist
International Olympic Committee Medical Commission, Lausanne, Switzerland
Clin Sports Med 27:231-9, x-xi. 2008..The International Olympic Committee (IOC) now has high-level scientific advisors who can advise the IOC as to the use and abuse of these technologies... - Anthropometry, physical performance, and ultrasound patellar tendon abnormality in elite junior basketball players: a cross-sectional studyJ L Cook
Musculoskeletal Research Centre, La Trobe University, Bundoora, VIC 3083, Australia
Br J Sports Med 38:206-9. 2004..This cross-sectional study examined the anthropometric and physical performance results of elite junior basketball players with normal or abnormal patellar tendons to see if any measures were associated with changes in tendon morphology... - Pituitary adenylyl cyclase-activating polypeptide (PACAP) and its receptor (PAC1-R) are positioned to modulate afferent signaling in the cochleaM J Drescher
Laboratory of Bio Otology, Department of Otolaryngology, Wayne State University School of Medicine, 261 Lande Medical Research Building, 540 East Canfield Avenue, Detroit, MI 48201, USA
Neuroscience 142:139-64. 2006..Additionally, PACAP/PAC1-R may modulate secretion of catecholamines from adrenergic terminals within the organ of Corti...