Bradley J Kerr
Affiliation: University of Alberta
Benson C, Paylor J, Tenorio G, Winship I, Baker G, Kerr B. Voluntary wheel running delays disease onset and reduces pain hypersensitivity in early experimental autoimmune encephalomyelitis (EAE). Exp Neurol. 2015;271:279-90 pubmed publisher
..Together these results indicate that in mice with EAE, voluntary motor activity can delay the onset of clinical signs and reduce pain symptoms associated with the disease. ..
Potter L, Doolen S, Mifflin K, Tenorio G, Baker G, Taylor B, et al
. Antinociceptive Effects of the Antidepressant Phenelzine are Mediated by Context-Dependent Inhibition of Neuronal Responses in the Dorsal Horn. Neuroscience. 2018;383:205-215 pubmed publisher
..We conclude that PLZ exerts antinociceptive effects through a 5-HT/5HT1AR-dependent inhibition of neuronal responses within nociceptive circuits of the dorsal horn. ..
Mifflin K, Benson C, Thorburn K, Baker G, Kerr B. Manipulation of Neurotransmitter Levels Has Differential EffectsÂ on Formalin-Evoked Nociceptive Behavior in Male andÂ Female Mice. J Pain. 2016;17:483-98 pubmed publisher
..The present study found that nociception in male and female mice may be regulated by different neurotransmitter systems. These results indicate that different pharmacological approaches may be needed to treat pain in both sexes. ..
Yousuf M, Kerr B. The Role of Regulatory Transporters in Neuropathic Pain. Adv Pharmacol. 2016;75:245-71 pubmed publisher
..This chapter explores various reuptake transporter systems and implicates their role in pain processing. Understanding the transporter systems will enhance drug discovery targeting different facets of neuropathic pain. ..
Potter L, Paylor J, Suh J, Tenorio G, Caliaperumal J, Colbourne F, et al
. Altered excitatory-inhibitory balance within somatosensory cortex is associated with enhanced plasticity and pain sensitivity in a mouse model of multiple sclerosis. J Neuroinflammation. 2016;13:142 pubmed publisher
..They also suggest a novel antinociceptive effect of PLZ treatment. ..
Yousuf M, Zubkow K, Tenorio G, Kerr B. The chloride co-transporters, NKCC1 and KCC2, in experimental autoimmune encephalomyelitis (EAE). Neuroscience. 2017;344:178-186 pubmed publisher
..These results indicate that mechanical hypersensitivity in EAE is not mediated by altered levels of NKCC1. ..
Mifflin K, Frieser E, Benson C, Baker G, Kerr B. Voluntary wheel running differentially affects disease outcomes in male and female mice with experimental autoimmune encephalomyelitis. J Neuroimmunol. 2017;305:135-144 pubmed publisher
..Taken together, our results indicate that the inflammatory response generated in EAE is distinct between the sexes and its modulation by daily exercise can have sex-specific effects on disease-related outcomes. ..