Armand Keating

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. doi request reprint Mesenchymal stromal cells: new directions
    Armand Keating
    Cell Therapy Program, Princess Margaret Hospital, Toronto, ON M5G 2M9, Canada
    Cell Stem Cell 10:709-16. 2012
  2. ncbi request reprint Bone marrow cells for cardiac repair
    Armand Keating
    Princvess Margaret Hospital, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
    Biol Blood Marrow Transplant 11:2-6. 2005
  3. pmc Mesenchymal stromal cells
    Armand Keating
    Princess Margaret Hospital Ontario Cancer Institute, Faculty of Medicine and Institute for Biomaterials and Biomedical Engineering, University of Toronto, ON, Canada
    Curr Opin Hematol 13:419-25. 2006
  4. doi request reprint How do mesenchymal stromal cells suppress T cells?
    Armand Keating
    Princess Margaret Hospital, 610 University Avenue, Suite 5 303, Toronto, ON M5G 2M9, Canada
    Cell Stem Cell 2:106-8. 2008
  5. pmc Second-line salvage chemotherapy for transplant-eligible patients with Hodgkin's lymphoma resistant to platinum-containing first-line salvage chemotherapy
    Diego Villa
    Autologous Blood and Marrow Transplant Program, Princess Margaret Hospital, Toronto, ON, Canada
    Haematologica 97:751-7. 2012
  6. pmc Different response to salvage chemotherapy but similar post-transplant outcomes in patients with relapsed and refractory Hodgkin's lymphoma
    Noemi Puig
    Division of Medical Oncology and Hematology, Princess Margaret Hospital, 610 University Avenue, Room 5 221, Toronto M5G 2M9, Canada
    Haematologica 95:1496-502. 2010
  7. doi request reprint Treatment response and overall outcome of patients with relapsed and refractory peripheral T-cell lymphoma compared to diffuse large B-cell lymphoma
    Noemi Puig
    Division of Medical Oncology and Hematology, Princess Margaret Hospital, Toronto, Ontario, Canada
    Leuk Lymphoma 54:507-13. 2013
  8. doi request reprint Lack of microsomal prostaglandin E(2) synthase-1 in bone marrow-derived myeloid cells impairs left ventricular function and increases mortality after acute myocardial infarction
    Norbert Degousee
    Division of Vascular Surgery, Toronto General Hospital, University Health Network, Toronto, Canada
    Circulation 125:2904-13. 2012
  9. pmc Human mesenchymal stromal cells improve scar thickness without enhancing cardiac function in a chronic ischaemic heart failure model
    Victor Dayan
    Cell Therapy Program, Princess Margaret Hospital, University Health Network, Toronto, Canada
    Interact Cardiovasc Thorac Surg 14:516-20. 2012
  10. doi request reprint Role of salvage radiation therapy for patients with relapsed or refractory hodgkin lymphoma who failed autologous stem cell transplant
    Jayant S Goda
    Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
    Int J Radiat Oncol Biol Phys 84:e329-35. 2012

Detail Information

Publications84

  1. doi request reprint Mesenchymal stromal cells: new directions
    Armand Keating
    Cell Therapy Program, Princess Margaret Hospital, Toronto, ON M5G 2M9, Canada
    Cell Stem Cell 10:709-16. 2012
    ..Taken together, a reappraisal of the definition of MSCs, a review of current research directions, and a reassessment of the approach to clinical investigation are timely and prudent...
  2. ncbi request reprint Bone marrow cells for cardiac repair
    Armand Keating
    Princvess Margaret Hospital, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
    Biol Blood Marrow Transplant 11:2-6. 2005
  3. pmc Mesenchymal stromal cells
    Armand Keating
    Princess Margaret Hospital Ontario Cancer Institute, Faculty of Medicine and Institute for Biomaterials and Biomedical Engineering, University of Toronto, ON, Canada
    Curr Opin Hematol 13:419-25. 2006
    ..stem cells or multipotent mesenchymal stromal cells has expanded dramatically over the last 3 years and is likely to have an impact on clinical practice in the near future, making a review of this topic both timely and relevant..
  4. doi request reprint How do mesenchymal stromal cells suppress T cells?
    Armand Keating
    Princess Margaret Hospital, 610 University Avenue, Suite 5 303, Toronto, ON M5G 2M9, Canada
    Cell Stem Cell 2:106-8. 2008
    ..In this issue of Cell Stem Cell, Ren et al. (2008) provide evidence for a possible underlying mechanism of MSC-mediated T cell suppression. A perspective for considering these interesting observations is discussed...
  5. pmc Second-line salvage chemotherapy for transplant-eligible patients with Hodgkin's lymphoma resistant to platinum-containing first-line salvage chemotherapy
    Diego Villa
    Autologous Blood and Marrow Transplant Program, Princess Margaret Hospital, Toronto, ON, Canada
    Haematologica 97:751-7. 2012
    ....
  6. pmc Different response to salvage chemotherapy but similar post-transplant outcomes in patients with relapsed and refractory Hodgkin's lymphoma
    Noemi Puig
    Division of Medical Oncology and Hematology, Princess Margaret Hospital, 610 University Avenue, Room 5 221, Toronto M5G 2M9, Canada
    Haematologica 95:1496-502. 2010
    ..Aiming to shed light on this issue, we analyzed and compared the outcomes of patients with relapsed or refractory Hodgkin's lymphoma treated with second-line chemotherapy and planned autologous stem-cell transplantation...
  7. doi request reprint Treatment response and overall outcome of patients with relapsed and refractory peripheral T-cell lymphoma compared to diffuse large B-cell lymphoma
    Noemi Puig
    Division of Medical Oncology and Hematology, Princess Margaret Hospital, Toronto, Ontario, Canada
    Leuk Lymphoma 54:507-13. 2013
    ..Strategies aiming to maintain response duration post-autologous stem cell transplant could improve the outcome of patients with peripheral T-cell lymphoma...
  8. doi request reprint Lack of microsomal prostaglandin E(2) synthase-1 in bone marrow-derived myeloid cells impairs left ventricular function and increases mortality after acute myocardial infarction
    Norbert Degousee
    Division of Vascular Surgery, Toronto General Hospital, University Health Network, Toronto, Canada
    Circulation 125:2904-13. 2012
    ..In this study, we define the role of mPGES-1 in bone marrow-derived leukocytes in the recovery of LV function after coronary ligation...
  9. pmc Human mesenchymal stromal cells improve scar thickness without enhancing cardiac function in a chronic ischaemic heart failure model
    Victor Dayan
    Cell Therapy Program, Princess Margaret Hospital, University Health Network, Toronto, Canada
    Interact Cardiovasc Thorac Surg 14:516-20. 2012
    ..Human MSCs increased the thickness of the infarcted ventricular wall without improving cardiac function in this chronic ischaemic heart failure model. Further studies are required to assess the benefit of MSCs in this setting...
  10. doi request reprint Role of salvage radiation therapy for patients with relapsed or refractory hodgkin lymphoma who failed autologous stem cell transplant
    Jayant S Goda
    Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
    Int J Radiat Oncol Biol Phys 84:e329-35. 2012
    ..To analyze, through chart review, the efficacy of salvage radiation therapy (sRT) for relapsed or progressive Hodgkin lymphoma (HL) patients who failed autologous stem cell transplant (ASCT)...
  11. ncbi request reprint Activation of c-kit is necessary for mobilization of reparative bone marrow progenitor cells in response to cardiac injury
    Shafie S Fazel
    Division of Cardiac Surgery, Department of Surgery, Toronto General Hospital Research Institute, Toronto, ON, Canada, M5G 1L7
    FASEB J 22:930-40. 2008
    ..Amplification of this pathway may aid in restoration of cardiac function after myocardial infarction...
  12. doi request reprint Incidence and risk factors for second cancers after autologous hematopoietic cell transplantation for aggressive non-Hodgkin lymphoma
    Tara Seshadri
    Division of Medical Oncology and Hematology, Princess Margaret Hospital, Toronto, Ontario, Canada
    Leuk Lymphoma 50:380-6. 2009
    ..004). In conclusion, second cancers are a significant cause of late morbidity and mortality patients treated with AHCT with curative intent, and appear increased in patients exposed to mini-BEAM chemotherapy...
  13. doi request reprint Mesenchymal stromal cells mediate a switch to alternatively activated monocytes/macrophages after acute myocardial infarction
    Victor Dayan
    Cell Therapy Program, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Canada
    Basic Res Cardiol 106:1299-310. 2011
    ..Additional studies are warranted confirming the role of IL-10 and augmenting the anti-inflammatory effects of MSCs in cardiac regeneration...
  14. ncbi request reprint Oligodendrocytes and radial glia derived from adult rat spinal cord progenitors: morphological and immunocytochemical characterization
    Iris Kulbatski
    Institute of Medical Science, University of Toronto, Toronto, Canada
    J Histochem Cytochem 55:209-22. 2007
    ..These findings indicate that adult rat spinal cord ependymal NPCs differentiate preferentially into oligodendrocytes and RG, which may support axonal regeneration in future trials of transplant therapy for spinal cord injury...
  15. doi request reprint An adult uterine hemangioblast: evidence for extramedullary self-renewal and clonal bilineage potential
    Zhuo Sun
    Division of Cardiovascular Surgery, University Health Network and University of Toronto, Toronto, ON, Canada
    Blood 116:2932-41. 2010
    ..Our findings offer new understanding of uterine cell renewal and turnover and may provide insights and opportunities for the study of stem cell maintenance...
  16. doi request reprint Human Vδ1 γδ T cells expanded from peripheral blood exhibit specific cytotoxicity against B-cell chronic lymphocytic leukemia-derived cells
    Gabrielle M Siegers
    Cell Therapy Program, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada
    Cytotherapy 13:753-64. 2011
    ..We have developed a protocol to expand Vδ1 and Vδ2 preferentially from human blood. We have characterized these subsets and their specificities for leukemic targets...
  17. doi request reprint Airway regeneration: the role of the Clara cell secretory protein and the cells that express it
    Amy P Wong
    Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, and the McEwen Centre for Regenerative Medicine, Toronto, Ontario, Canada
    Cytotherapy 11:676-87. 2009
    ..The use of this protein or CCSP-expressing cells as an indication of biologic processes that contribute to lung injury or repair is highlighted...
  18. ncbi request reprint Intravenously administered bone marrow cells migrate to damaged brain tissue and improve neural function in ischemic rats
    Jiang Wu
    Division of Cardiovascular Surgery, Toronto General Research Institute and University of Toronto, Toronto, Ontario, Canada
    Cell Transplant 16:993-1005. 2008
    ..Intravenously administrated BMSCs facilitated the structural and functional recovery of neural tissue following ischemic injury, perhaps mediated by enhanced angiogenesis...
  19. doi request reprint Salvage chemotherapy and autologous stem cell transplantation are inferior for relapsed or refractory primary mediastinal large B-cell lymphoma compared with diffuse large B-cell lymphoma
    John Kuruvilla
    Division of Medical Oncology and Hematology, Princess Margaret Hospital, Toronto, Canada
    Leuk Lymphoma 49:1329-36. 2008
    ..Strategies for PMLCL should focus on identifying poor risk patients to test novel induction and salvage strategies...
  20. doi request reprint Bone marrow-derived mesenchymal stromal cells express cardiac-specific markers, retain the stromal phenotype, and do not become functional cardiomyocytes in vitro
    Robert A Rose
    Department of Physiology, Heart and Stroke Richard Lewar Centre, University Health Network, Princess Margaret Hospital, Ontario Cancer Institute, Toronto, Ontario, Canada
    Stem Cells 26:2884-92. 2008
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  21. ncbi request reprint Human umbilical cord perivascular cells exhibit enhanced cardiomyocyte reprogramming and cardiac function after experimental acute myocardial infarction
    Gustavo Yannarelli
    Cell Therapy Program, Prince Margaret Hospital, University Health Network, Toronto, ON, Canada M5G2M9
    Cell Transplant 22:1651-66. 2013
    ..Our results indicate that HUCPVCs exhibit a greater degree of cardiomyocyte reprogramming but that differentiation for both cell types is partial. We conclude that HUCPVCs may be preferable to BM-MSCs in the cell therapy of AMI. ..
  22. pmc Natural killer cell lines preferentially kill clonogenic multiple myeloma cells and decrease myeloma engraftment in a bioluminescent xenograft mouse model
    Brenna E Swift
    Cell Therapy Program, Princess Margaret Hospital, 610 University Ave, Toronto, ON, Canada
    Haematologica 97:1020-8. 2012
    ..This study investigates the cytotoxicity of natural killer cell lines against bulk and clonogenic multiple myeloma and evaluates the tumor burden after NK cell therapy in a bioluminescent xenograft mouse model...
  23. doi request reprint Salvage chemotherapy and autologous stem cell transplant in primary refractory diffuse large B-cell lymphoma: outcomes and prognostic factors
    David Telio
    Division of Medical Oncology and Hematology, Princess Margaret Hospital, Toronto, ON, Canada
    Leuk Lymphoma 53:836-41. 2012
    ..Second-generation platinum-containing regimens (ESHAP, GDP) may be superior to DHAP in this setting. Novel, prospectively evaluated treatment approaches should be pursued in REF DLBCL...
  24. doi request reprint How I treat relapsed and refractory Hodgkin lymphoma
    John Kuruvilla
    Division of Medical Oncology and Hematology, Princess Margaret Hospital, Toronto, ON, Canada
    Blood 117:4208-17. 2011
    ..Patients have effective options beyond primary therapy, and continued progress through controlled trials remains a tangible goal in the treatment of relapsed and refractory disease...
  25. ncbi request reprint Autologous stem cell transplant for relapsed and refractory peripheral T-cell lymphoma: variable outcome according to pathological subtype
    Kevin W Song
    University of Toronto Autologous Blood and Marrow Transplant Program, Princess Margaret Hospital, Toronto, Ontario, Canada
    Br J Haematol 120:978-85. 2003
    ..41). While ASCT in patients with relapsed or primary refractory PTL results in long-term remission rates comparable to DLBL patients, those with PTL-NOS do significantly worse...
  26. ncbi request reprint Donor mesenchymal stromal cells (MSCs) undergo variable cardiac reprogramming in vivo and predominantly co-express cardiac and stromal determinants after experimental acute myocardial infarction
    Gustavo Yannarelli
    Cell Therapy Program, Princess Margaret Hospital, University Health Network, University of Toronto, 610 University Ave, Suite 5 303, Toronto, ON, Canada, M5G 2M9
    Stem Cell Rev 10:304-15. 2014
    ..Further studies are needed to elucidate the factors mediating the extent of cardiomyocyte reprogramming and importance of the cellular changes on tissue repair...
  27. doi request reprint Clonogenic assays measure leukemia stem cell killing not detectable by chromium release and flow cytometric cytotoxicity assays
    Brent A Williams
    Cell Therapy Program, Princess Margaret Hospital, University of Toronto, Canada
    Cytotherapy 12:951-60. 2010
    ..While the chromium-release assay is the most common method for assessing cytotoxicity of immune effectors, and flow cytometry is increasingly used, the relationship of either assay to clonogenic readouts remains unknown...
  28. doi request reprint Salvage therapy for relapsed/refractory diffuse large B cell lymphoma
    Tara Seshadri
    Autologous Blood and Marrow Transplant Program, Princess Margaret Hospital, Toronto, Ontario, Canada
    Biol Blood Marrow Transplant 14:259-67. 2008
    ..This review focuses on prognostic markers, current salvage therapies, and discusses the role of novel treatment in the management of relapsed/refractory DLBCL...
  29. pmc Identification of a bone marrow-derived epithelial-like population capable of repopulating injured mouse airway epithelium
    Amy P Wong
    Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, and the McEwen Centre in Regenerative Medicine, Toronto, Ontario, Canada
    J Clin Invest 119:336-48. 2009
    ..Additionally, these data could reconcile previous controversies regarding the contribution of bone marrow to lung regeneration...
  30. ncbi request reprint Local radiotherapy induces homing of hematopoietic stem cells to the irradiated bone marrow
    Carlo Bastianutto
    Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    Cancer Res 67:10112-6. 2007
    ..Our data also suggest some opportunities for leukemia prevention in breast cancer patients undergoing RT...
  31. ncbi request reprint Similar response rates and superior early progression-free survival with gemcitabine, dexamethasone, and cisplatin salvage therapy compared with carmustine, etoposide, cytarabine, and melphalan salvage therapy prior to autologous stem cell transplantation
    John Kuruvilla
    Division of Medical Oncology and Hematology, Princess Margaret Hospital, Toronto, Canada
    Cancer 106:353-60. 2006
    ....
  32. pmc Autologous blood cell transplantation versus HLA-identical sibling transplantation for acute myeloid leukemia in first complete remission: a registry study from the Center for International Blood and Marrow Transplantation Research
    Armand Keating
    Princess Margaret Hospital, University of Toronto, Ontario, Canada
    Haematologica 98:185-92. 2013
    ..In the absence of an HLA-matched sibling donor, autologous peripheral blood may provide acceptable alternative post-remission therapy for patients with acute myeloid leukemia in first complete remission...
  33. doi request reprint Brief report: The potential role of epigenetics on multipotent cell differentiation capacity of mesenchymal stromal cells
    Gustavo Yannarelli
    Cell Therapy Program, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada
    Stem Cells 31:215-20. 2013
    ..These results are consistent with the notion that the MSC population (whether BM- or HUCPV-derived) exhibits higher proliferative capacity and contains more progenitor cells than do dermal fibroblasts...
  34. pmc Anti-leukemia activity of in vitro-expanded human gamma delta T cells in a xenogeneic Ph+ leukemia model
    Gabrielle M Siegers
    Cell Therapy Program, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada
    PLoS ONE 6:e16700. 2011
    ..In therapy experiments, we documented decreased bone marrow leukemia burden in mice treated with GDTc. Live GDTc were found in spleen and bone marrow at endpoint, suggesting the potential usefulness of this therapy...
  35. doi request reprint Rosuvastatin, identified from a zebrafish chemical genetic screen for antiangiogenic compounds, suppresses the growth of prostate cancer
    Chunyang Wang
    Keenan Research Center, Li Ka Shing Knowledge Institute, St Michael s Hospital and Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Eur Urol 58:418-26. 2010
    ..Recent clinical trials have shown encouraging results regarding the application of angiogenic inhibitors in the treatment of angiogenesis-dependent diseases, paving the way for novel PCa therapies...
  36. doi request reprint Enhanced adaptive immunity in mice lacking the immunoinhibitory adaptor Hacs1
    Dingyan Wang
    St Michael s Hospital, 30 Bond St, Queen Wing, Rm 8 019, Toronto, ON, Canada M5B 1W8
    FASEB J 24:947-56. 2010
    ..Wang, D., Stewart, A. K., Zhuang, L., Zhu, Y., Wang, Y., Shi, C., Keating, A., Slutsky, A., Zhang, H., Wen, X.-Y. Enhanced adaptive immunity in mice lacking the immunoinhibitory adaptor Hacs1...
  37. doi request reprint Is there a role for autotransplants in AML in first remission?
    Tara Seshadri
    Princess Margaret Hospital and the University of Toronto, Toronto, ON, Canada
    Biol Blood Marrow Transplant 15:17-20. 2009
    ..In this brief review, a rationale for a reexamination of the use of autotransplants for de novo AML in CR1 is explored...
  38. ncbi request reprint Constitutively polarized granules prime KHYG-1 NK cells
    Garnet Suck
    Department of Medical Oncology and Hematology, Princess Margaret Hospital Ontario Cancer Institute, 610 University Avenue, Suite 5 211, Toronto, ON M5G2M9, Canada
    Int Immunol 18:1347-54. 2006
    ..Thus, a functional role for NKG2D in KHYG-1 cytotoxicity is demonstrated. Moreover, the novel primed state may contribute to the high cytotoxicity exhibited by KHYG-1...
  39. ncbi request reprint Acute promyelocytic leukemia: a case-based review
    Vikas Gupta
    Department of Medical Oncology and Hematology, Princess Margaret Hospital, University of Toronto, Toronto, Canada M5G 2M9
    Hematology 8:105-13. 2003
    ..The main aim of this review is to highlight recent progress made in the management of APL and address the role of maintenance therapy, prognostic factors for relapse and treatment of relapsed disease...
  40. ncbi request reprint KHYG-1, a model for the study of enhanced natural killer cell cytotoxicity
    Garnet Suck
    Department of Medical Oncology and Hematology, Princess Margaret Hospital Ontario Cancer Institute, Toronto, Ontario, Canada
    Exp Hematol 33:1160-71. 2005
    ..To compare the cytotoxicity of KHYG-1 with other natural killer (NK)/NK T-cell lines and identify molecules that may be associated with enhanced cytotoxicity, thereby eventually leading to improved NK cell-mediated cancer immunotherapy...
  41. doi request reprint Mesenchymal stromal cells augment CD4+ and CD8+ T-cell proliferation through a CCL2 pathway
    Yingzhe Zhou
    Latner Thoracic Surgery Research Laboratories, Division of Thoracic Surgery, University Health Network, Toronto, Ontario, Canada
    Cytotherapy 15:1195-207. 2013
    ..Recent evidence, however, has shown that in certain settings, MSC can also be immunostimulatory. The mechanisms involved in this process are largely unknown...
  42. doi request reprint Extensive expansion of primary human gamma delta T cells generates cytotoxic effector memory cells that can be labeled with Feraheme for cellular MRI
    Gabrielle M Siegers
    Imaging Research Laboratories, Robarts Research Institute, Western University, London, ON, Canada
    Cancer Immunol Immunother 62:571-83. 2013
    ..MRI of GDTc in agarose phantoms was performed at 3 Tesla. The signal-to-noise ratios for unlabeled and labeled cells were 56 and 21, respectively. Thus, Feraheme-labeled GDTc could be readily detected in vitro via MRI...
  43. doi request reprint Cell therapy for age-related disorders: myocardial infarction and stroke--a mini-review
    Brent A Williams
    Cell Therapy Program, Princess Margaret Hospital, Ontario Cancer Institute, Toronto, Ontario, Canada
    Gerontology 54:300-11. 2008
    ..As the field of stem cell biology has progressed, cell therapies for the treatment of myocardial infarction and stroke have been tested in early stage clinical trials using a variety of cellular agents...
  44. pmc Group V phospholipase A2 in bone marrow-derived myeloid cells and bronchial epithelial cells promotes bacterial clearance after Escherichia coli pneumonia
    Norbert Degousee
    Division of Vascular Surgery, Peter Munk Cardiac Centre, University of Toronto, Toronto, Ontario M5G 2C4, Canada
    J Biol Chem 286:35650-62. 2011
    ..coli...
  45. pmc Human mesenchymal stem cells self-renew and differentiate according to a deterministic hierarchy
    Rahul Sarugaser
    Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 4:e6498. 2009
    ..Accordingly, the term "MSC" has been criticised, as there is little data demonstrating self-renewal of definitive single-cell-derived (SCD) clonal populations from a mesenchymal cell source...
  46. ncbi request reprint rbm47, a novel RNA binding protein, regulates zebrafish head development
    Rui Guan
    Zebrafish Centre for Advanced Drug Discovery, Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada Department of Medicine, Physiology and Institute of Medical Science, University of Toronto, Canada Department of Laboratory Medicine and Pathology, University of Toronto and Program in Physiology and Experimental Medicine, The Hospital for Sick Children, Toronto, Canada Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, Xiangya Hospital and Cancer Research Institute, Central South, Hunan Province, China
    Dev Dyn 242:1395-404. 2013
    ..RNA binding proteins play diverse roles in embryonic development and their roles in vertebrate head development remain to be elucidated...
  47. pmc Overcoming challenges to initiating cell therapy clinical trials in rapidly developing countries: India as a model
    Sowmya Viswanathan
    Cell Therapy Program, University Health Network, Princess Margaret Hospital, Toronto, Ontario, Canada
    Stem Cells Transl Med 2:607-13. 2013
    ..By doing so, these countries would have taken one important step to move to the forefront of stem cell-based therapeutics. ..
  48. doi request reprint The effect of local breast radiotherapy on circulating CD34(+) cells
    Nehad M Alajez
    Ontario Cancer Institute, Toronto, Canada
    Radiother Oncol 100:304-7. 2011
    ..These data demonstrate that local radiation therapy can profoundly affect HSC homeostasis, which might have a myriad of important implications...
  49. doi request reprint Cell-based therapies for osteonecrosis of the femoral head
    Kevin B Jones
    Division of Orthopedics, Department of Surgery, Mount Sinai Hospital, Toronto, Ontario, Canada
    Biol Blood Marrow Transplant 14:1081-7. 2008
    ..This review presents an overview of osteonecrosis with particular emphasis on HCT recipients and introduces the role of cell therapy, especially with mesenchymal stromal cells, as a promising new treatment...
  50. pmc Allogeneic hematopoietic cell transplantation in human immunodeficiency virus-positive patients with hematologic disorders: a report from the center for international blood and marrow transplant research
    Vikas Gupta
    Division of Haematology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
    Biol Blood Marrow Transplant 15:864-71. 2009
    ..Prospective studies are needed to evaluate the safety and efficacy of this modality in specific diseases in these patients...
  51. pmc Mesenchymal stromal cells as supportive cells for hepatocytes
    Alejandro Gómez-Aristizábal
    Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada
    Mol Ther 17:1504-8. 2009
    ..These observations suggest that allogeneic MSCs may be useful not only in supporting hepatocyte growth and proliferation but also in modulating immune responses such as stellate cell activation...
  52. pmc Cardioprotective c-kit+ cells are from the bone marrow and regulate the myocardial balance of angiogenic cytokines
    Shafie Fazel
    Division of Cardiovascular Surgery, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Clin Invest 116:1865-77. 2006
    ..We conclude that, consistent with their documented role in tumorigenesis, bone marrow c-kit+ cells act as key regulators of the angiogenic switch in infarcted myocardium, thereby driving efficient cardiac repair...
  53. ncbi request reprint The autologous blood and marrow transplant long-term follow-up clinic: a model of care for following and treating survivors of autotransplant
    Aaron D Schimmer
    ABMT Long term Follow up Research Unit, Princess Margaret Hospital, University of Toronto, ABMT Program, Canada
    Support Care Cancer 10:247-52. 2002
    ..In conclusion, we present an inexpensive model of care for ABMT survivors that can be extended to adult survivors of malignancy not treated by ABMT...
  54. pmc Soliciting strategies for developing cell-based reference materials to advance mesenchymal stromal cell research and clinical translation
    Sowmya Viswanathan
    1 Cell Therapy Program, University Health Network, Toronto, ON, Canada
    Stem Cells Dev 23:1157-67. 2014
    ..Importantly, a reference material may enable a consensus on a practical definition of MSCs. ..
  55. ncbi request reprint A roadmap to safe, efficient, and stable lentivirus-mediated gene therapy with hematopoietic cell transplantation
    Anton Neschadim
    Division of Stem Cell and Developmental Biology, Ontario Cancer Institute, Toronto, Ontario, Canada
    Biol Blood Marrow Transplant 13:1407-16. 2007
    ..Finally, this review underlines the specific advantages offered by lentiviral gene-transfer vectors for gene therapy in stem cells...
  56. doi request reprint Overcoming the challenges of conducting translational research in cell therapy
    Sowmya Viswanathan
    Cell Therapy Program, Princess Margaret Hospital, University Health Network, Toronto, ON, M5G 2M9, Canada
    Front Med 5:333-5. 2011
    ..Nonetheless, several initiatives to address all of these issues are underway...
  57. ncbi request reprint Effect of radiation and cell implantation on wound healing in a rat model
    Dale Dantzer
    The Samuel Lunenfeld Research Institute, Sinai Hospital, Toronto, Ontario, Canada
    J Surg Oncol 83:185-90. 2003
    ..Having shown that intra-dermal injection of fibroblasts decreases the effect of radiation on healing of superficial wounds, we now test the effect of fibroblasts and syngeneic marrow stromal cells on irradiated deep and superficial wounds...
  58. ncbi request reprint Flow cytometric assessment of autologous gammadelta T cells in patients with acute myeloid leukemia: potential effector cells for immunotherapy?
    Jorg M Aswald
    Department of Medical Oncology and Hematology, Princess Margaret Hospital Ontario Cancer Institute, Toronto, Ontario, Canada M5G 2M9
    Cytometry B Clin Cytom 70:379-90. 2006
    ..The aim of the study was to enumerate peripheral blood gammadelta T cells in patients with AML and explore the feasibility of their use clinically...
  59. ncbi request reprint Analysis of green fluorescent protein expression in transgenic rats for tracking transplanted neural stem/progenitor cells
    Andrea J Mothe
    Division of Cellular and Molecular Biology, Toronto Western Research Institute, Ontario, Canada
    J Histochem Cytochem 53:1215-26. 2005
    ..The cultured stem/progenitor cells transplanted into the spinal cord survived for at least 49 days after transplantation, and continued to express GFP, demonstrating stable expression of the GFP transgene in vivo...
  60. doi request reprint Older patients with acute myeloid leukemia
    Karen W L Yee
    Division of Medical Oncology and Hematology, University Health Network Princess Margaret Hospital, 610 University Avenue, Toronto, Ontario, Canada
    Expert Rev Hematol 3:755-74. 2010
    ....
  61. ncbi request reprint A phase II study of thalidomide and vinblastine for palliative patients with Hodgkin's lymphoma
    John Kuruvilla
    The University of Toronto Autologous Blood and Marrow Transplant Program, Princess Margaret Hospital, Toronto, Ont, Canada
    Hematology 11:25-9. 2006
    ....
  62. pmc Culture-modified bone marrow cells attenuate cardiac and renal injury in a chronic kidney disease rat model via a novel antifibrotic mechanism
    Darren A Yuen
    Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael s Hospital, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 5:e9543. 2010
    ..In exploring the therapeutic potential of bone marrow derived cells in chronic cardio-renal disease, we examined the anti-fibrotic effects of bone marrow-derived culture modified cells (CMCs) and stromal cells (SCs)...
  63. ncbi request reprint Donor stem cells home to marrow efficiently and contribute to short- and long-term hematopoiesis after low-cell-dose unconditioned bone marrow transplantation
    Simon J Bubnic
    Toronto General Research Institute, Toronto, Ontario, Canada
    Exp Hematol 30:606-11. 2002
    ..To study the homing of donor stem cells, their contribution to short- and long-term hematopoiesis, and their functional capacity in an unconditioned marrow transplant model using a clinically relevant low marrow cell dose...
  64. ncbi request reprint Biomarkers of potential prognostic significance in diffuse large B-cell lymphoma
    Grace Wu
    Department of Medical Oncology and Hematology, Princess Margaret Hospital Ontario Cancer Institute, University of Toronto, Toronto, Ontario, Canada
    Cancer 106:247-57. 2006
    ..The goal is to be able to identify subgroups of patients at high risk of treatment failure and develop more effective treatment based on specific biological defects that may represent new rational therapeutic targets...
  65. ncbi request reprint Pretransplantation consolidation chemotherapy decreases leukemia relapse after autologous blood and bone marrow transplants for acute myelogenous leukemia in first remission
    Martin S Tallman
    Northwestern University Medical School, Chicago, Illinois, USA
    Biol Blood Marrow Transplant 12:204-16. 2006
    ..Outcomes with standard-dose and high-dose cytarabine were similar. Based on our findings, we recommend that patients with AML in first remission receive consolidation before undergoing autotransplantation...
  66. ncbi request reprint Comparison of outcome following allogeneic bone marrow transplantation with cyclophosphamide-total body irradiation versus busulphan-cyclophosphamide conditioning regimens for acute myelogenous leukaemia in first remission
    Mark R Litzow
    Mayo Clinic and Foundation, Rochester, MN, USA
    Br J Haematol 119:1115-24. 2002
    ..016). There were no differences in TRM, LFS and OS. CyTBI conditioning may lower relapse risk but produces comparable TRM, LFS and OS to BuCy for HLA-matched sibling transplantation in first remission AML...
  67. ncbi request reprint Myelodysplastic syndrome and acute myeloid leukemia after autotransplantation for lymphoma: a multicenter case-control study
    Catherine Metayer
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Blood 101:2015-23. 2003
    ..Transplantation-related factors may also modulate this risk; however, the apparent contribution of high-dose TBI requires confirmation...
  68. ncbi request reprint Bone marrow transplantation from HLA-identical siblings as treatment for myelodysplasia
    Jorge Sierra
    International Bone Marrow Transplant Registry IBMTR, Health Policy Institute, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Blood 100:1997-2004. 2002
    ..Best candidates are younger patients with a low percentage of blasts and preserved platelet counts...
  69. ncbi request reprint Autologous versus allogeneic unrelated donor transplantation for acute lymphoblastic leukemia: comparative toxicity and outcomes
    Daniel Weisdorf
    University of Minnesota, the National Marrow Donor Program and the Autologous Blood and Marrow Transplant Registry, Minneapolis 55455, USA
    Biol Blood Marrow Transplant 8:213-20. 2002
    ....
  70. ncbi request reprint Predictive value of karyotype on outcome of autotransplants for acute myeloid leukemia in second remission
    Kevin W Song
    The Leukemia Bone Marrow Transplantation Program of British Columbia, Vancouver Hospital and Health Sciences Center, British Columbia Cancer Agency, University of British Columbia, Vancouver, British Columbia, Canada
    Leuk Lymphoma 46:525-31. 2005
    ..5-63.9); unknown 2.3 (0.6-8.8) (P=0.028). We conclude that patients with AML in CR2 who undergo autotransplant can have durable remissions and those with a good risk karyotype are the most likely to obtain long-term disease-free survival...
  71. ncbi request reprint Do mesenchymal stromal cells transdifferentiate into functional cardiomyocytes?
    Robert A Rose
    Circ Res 103:e120. 2008
  72. ncbi request reprint ABO blood group barrier in allogeneic bone marrow transplantation revisited
    Jörg D Seebach
    Department of Internal Medicine, University Hospital Zurich, Zurich, Switzerland
    Biol Blood Marrow Transplant 11:1006-13. 2005
    ..001). There was no evidence of a substantial effect of ABO blood group incompatibility on the outcome of conventional BMT among patients with leukemia...
  73. pmc Second autologous stem cell transplantation for relapsed lymphoma after a prior autologous transplant
    Sonali M Smith
    Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    Biol Blood Marrow Transplant 14:904-12. 2008
    ..HCT2 should be considered for patients with relapsed HL or NHL after HCT1 without alternative allogeneic stem cell transplant options...
  74. ncbi request reprint Autotransplantation versus HLA-matched unrelated donor transplantation for acute myeloid leukaemia: a retrospective analysis from the Center for International Blood and Marrow Transplant Research
    Hillard M Lazarus
    University Hospitals of Cleveland, Ireland Cancer Center, Cleveland, OH, USA
    Br J Haematol 132:755-69. 2006
    ..Cytogenetics, however, were known in only two-thirds of patients and treatment bias cannot be eliminated...
  75. pmc Unrelated donor transplants in adults with Philadelphia-negative acute lymphoblastic leukemia in first complete remission
    David I Marks
    Adult Blood and Marrow Transplantation BMT Unit, United Bristol Healthcare Trust, Bristol, United Kingdom
    Blood 112:426-34. 2008
    ..Nearly 40% of adults with ALL in CR1 survive 5 years after URD transplantation. Relapse risks were modest; TRM is the major cause of treatment failure. Selecting closely HLA-matched URD and reducing TRM should improve results...
  76. ncbi request reprint A comparison of cyclophosphamide and total body irradiation with etoposide and total body irradiation as conditioning regimens for patients undergoing sibling allografting for acute lymphoblastic leukemia in first or second complete remission
    David I Marks
    Adult BMT Unit, Bristol Children s Hospital, Bristol, UK
    Biol Blood Marrow Transplant 12:438-53. 2006
    ..We conclude that for HLA-identical sibling allografts for acute lymphoblastic leukemia in CR2, there is an advantage in substituting etoposide for Cy or, when Cy is used, in increasing the TBI dose to > or =13 Gy...
  77. pmc Impact of cytogenetics on outcome of matched unrelated donor hematopoietic stem cell transplantation for acute myeloid leukemia in first or second complete remission
    Martin S Tallman
    Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Blood 110:409-17. 2007
    ..However, treatment-related mortality was high. Matched unrelated donor HSCT should be considered for all patients with unfavorable cytogenetics who lack a suitable HLA-matched sibling donor...
  78. pmc Impact of prior imatinib mesylate on the outcome of hematopoietic cell transplantation for chronic myeloid leukemia
    Stephanie J Lee
    Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Blood 112:3500-7. 2008
    ..Acute graft-versus-host disease rates were similar between IM(+) and IM(-) groups regardless of leukemia phase. These results should be reassuring to patients receiving IM before HCT...
  79. doi request reprint The role of cytotoxic therapy with hematopoietic stem cell transplantation in the therapy of acute myelogenous leukemia in adults: an evidence-based review
    Denise M Oliansky
    Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Biol Blood Marrow Transplant 14:137-80. 2008
    ..conventional conditioning in older (>60 years) and intermediate (40-60 years) aged adults? (4) What is the impact on survival outcomes of unrelated donor HSCT vesus chemotherapy in younger (<40 years) adults with high risk disease?..
  80. ncbi request reprint Preparing for the unthinkable: emergency preparedness for the hematopoietic cell transplant program
    John R Wingard
    University of Florida College of Medicine, Gainesville, FL 32610 0277, USA
    Biol Blood Marrow Transplant 12:1229-38. 2006
    ..This report provides the framework for a HCT-specific emergency preparedness plan that can be used by individual centers to develop customized guidelines on preparing for, responding to, and recovering from an emergency...
  81. ncbi request reprint A decision analysis of allogeneic bone marrow transplantation for the myelodysplastic syndromes: delayed transplantation for low-risk myelodysplasia is associated with improved outcome
    Corey S Cutler
    International Bone Marrow Transplant Registry, Medical College of Wisconsin, 8701 Watertown Plank Rd, PO Box 26509, Milwaukee, WI 53226, USA
    Blood 104:579-85. 2004
    ..For low- and intermediate-1-risk MDS, delayed BMT is associated with maximal life expectancy, whereas immediate transplantation for intermediate-2- and high-risk disease is associated with maximal life expectancy...
  82. ncbi request reprint Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML
    Catriona H M Jamieson
    Division of Hematology, Stanford University School of Medicine, Stanford, Calif 94305 5323, USA
    N Engl J Med 351:657-67. 2004
    ..In normal mouse hematopoietic stem cells, the process of self-renewal involves the beta-catenin-signaling pathway. We investigated whether leukemic stem cells in CML also use the beta-catenin pathway for self-renewal...
  83. ncbi request reprint Donor hematopoietic cells from transgenic mice that express GFP are immunogenic in immunocompetent recipients
    Simon J Bubnic
    Osiris Therapeutics Inc, 2001 Aliceanna Street, Baltimore, MD 21231, USA
    Hematology 10:289-95. 2005
    ....
  84. ncbi request reprint Outcome of ethnic minorities with acute or chronic leukemia treated with hematopoietic stem-cell transplantation in the United States
    K Scott Baker
    Pediatric Blood and Marrow Transplant Program, University of Minnesota, Mayo Mail Code 484, Minneapolis, MN 55455, USA
    J Clin Oncol 23:7032-42. 2005
    ..The purpose of this study was to examine the relationship between ethnicity and post-transplantation events and determine their net effect on survival...