Keyvan Karkouti

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi Predicting difficult intubation: a multivariable analysis
    K Karkouti
    Department of Anaesthesia, Toronto General Hospital, University Health Network, Ontario, Canada
    Can J Anaesth 47:730-9. 2000
  2. ncbi Variability and predictability of large-volume red blood cell transfusion in cardiac surgery: a multicenter study
    Keyvan Karkouti
    University Health Network, Toronto General Hospital, Department of Anesthesia, Ontario, Canada
    Transfusion 47:2081-8. 2007
  3. ncbi Intravenous iron and recombinant erythropoietin for the treatment of postoperative anemia
    Keyvan Karkouti
    Toronto General Hospital, University Health Network, Department of Anesthesia, 3 Eaton North, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada
    Can J Anaesth 53:11-9. 2006
  4. ncbi Platelet transfusions are not associated with increased morbidity or mortality in cardiac surgery
    Keyvan Karkouti
    Department of Anesthesia, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Can J Anaesth 53:279-87. 2006
  5. ncbi A propensity score case-control comparison of aprotinin and tranexamic acid in high-transfusion-risk cardiac surgery
    Keyvan Karkouti
    Department of Anesthesia, University of Toronto, Toronto, Ontario, Canada
    Transfusion 46:327-38. 2006
  6. ncbi Prognostic value of postoperative proteinuria in cardiac surgery: a pilot study
    Keyvan Karkouti
    University Health Network, Toronto General Hospital, Department of Anesthesia, EN 3 402, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada
    Can J Anaesth 53:500-6. 2006
  7. ncbi Aprotinin is useful as a hemostatic agent in cardiopulmonary surgery: no
    K Karkouti
    Department of Anesthesia, Health Network, University of Toronto, Toronto, ON, Canada
    J Thromb Haemost 4:1879-81. 2006
  8. ncbi Prediction of massive blood transfusion in cardiac surgery
    Keyvan Karkouti
    University Health Network, Toronto General Hospital, Department of Anesthesia, EN 3 402, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada
    Can J Anaesth 53:781-94. 2006
  9. ncbi Determinants of complications with recombinant factor VIIa for refractory blood loss in cardiac surgery
    Keyvan Karkouti
    University of Toronto, University Health Network, Department of Anesthesia, 3 Eaton North, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada
    Can J Anaesth 53:802-9. 2006
  10. ncbi The effects of a treatment protocol for cardiac surgical patients with excessive blood loss on clinical outcomes
    K Karkouti
    Department of Anaesthesia, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Vox Sang 91:148-56. 2006

Detail Information

Publications63

  1. ncbi Predicting difficult intubation: a multivariable analysis
    K Karkouti
    Department of Anaesthesia, Toronto General Hospital, University Health Network, Ontario, Canada
    Can J Anaesth 47:730-9. 2000
    ..To develop a clinically useful and valid model for predicting difficult laryngoscopic tracheal intubation in patients with seemingly normal airways by adhering to the principles of multivariable model development...
  2. ncbi Variability and predictability of large-volume red blood cell transfusion in cardiac surgery: a multicenter study
    Keyvan Karkouti
    University Health Network, Toronto General Hospital, Department of Anesthesia, Ontario, Canada
    Transfusion 47:2081-8. 2007
    ..The objectives of this study were to measure the interinstitution variation and predictability of large-volume RBC transfusion...
  3. ncbi Intravenous iron and recombinant erythropoietin for the treatment of postoperative anemia
    Keyvan Karkouti
    Toronto General Hospital, University Health Network, Department of Anesthesia, 3 Eaton North, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada
    Can J Anaesth 53:11-9. 2006
    ..To determine if early recovery from severe post-operative anemia is accelerated by iv iron therapy alone or in combination with recombinant erythropoietin (EPO)...
  4. ncbi Platelet transfusions are not associated with increased morbidity or mortality in cardiac surgery
    Keyvan Karkouti
    Department of Anesthesia, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Can J Anaesth 53:279-87. 2006
    ..To determine the independent relationship between leukoreduced platelet transfusions and adverse events in cardiac surgery...
  5. ncbi A propensity score case-control comparison of aprotinin and tranexamic acid in high-transfusion-risk cardiac surgery
    Keyvan Karkouti
    Department of Anesthesia, University of Toronto, Toronto, Ontario, Canada
    Transfusion 46:327-38. 2006
    ..Prophylactic use of the antifibrinolytic drugs aprotinin and tranexamic acid is thought to prevent these hemostatic defects. Their relative clinical utility and safety in high-transfusion-risk cardiac surgery, however, is not known...
  6. ncbi Prognostic value of postoperative proteinuria in cardiac surgery: a pilot study
    Keyvan Karkouti
    University Health Network, Toronto General Hospital, Department of Anesthesia, EN 3 402, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada
    Can J Anaesth 53:500-6. 2006
    ..The objective of this pilot study was to determine if postoperative proteinuria is associated with adverse outcomes following cardiac surgery with cardiopulmonary bypass...
  7. ncbi Aprotinin is useful as a hemostatic agent in cardiopulmonary surgery: no
    K Karkouti
    Department of Anesthesia, Health Network, University of Toronto, Toronto, ON, Canada
    J Thromb Haemost 4:1879-81. 2006
  8. ncbi Prediction of massive blood transfusion in cardiac surgery
    Keyvan Karkouti
    University Health Network, Toronto General Hospital, Department of Anesthesia, EN 3 402, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada
    Can J Anaesth 53:781-94. 2006
    ..The objective of this study was to develop a prediction rule for massive blood transfusion (MBT) that could be used to optimize the management of, and research on, at-risk patients...
  9. ncbi Determinants of complications with recombinant factor VIIa for refractory blood loss in cardiac surgery
    Keyvan Karkouti
    University of Toronto, University Health Network, Department of Anesthesia, 3 Eaton North, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada
    Can J Anaesth 53:802-9. 2006
    ..Recombinant factor VIIa (rFVIIa) is being used for refractory, excessive blood loss (EBL) after cardiac surgery, but its safety for this indication is not known...
  10. ncbi The effects of a treatment protocol for cardiac surgical patients with excessive blood loss on clinical outcomes
    K Karkouti
    Department of Anaesthesia, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Vox Sang 91:148-56. 2006
    ..The objective of this before/after study was to determine whether the implementation of a protocol for management of cardiac surgical patients with EBL was associated with improved clinical outcomes...
  11. ncbi Acute kidney injury after cardiac surgery: focus on modifiable risk factors
    Keyvan Karkouti
    Department of Anesthesia and Health Policy, Management, and Evaluation, Toronto General Hospital, University of Toronto, 200 Elizabeth St, EN 3 402, Toronto, Ontario, Canada M5G 2C4
    Circulation 119:495-502. 2009
    ..Lacking effective therapies, risk factor modification may offer a means of preventing this complication. The objective of the present study was to identify and determine the prognostic importance of such risk factors...
  12. ncbi Comprehensive Canadian review of the off-label use of recombinant activated factor VII in cardiac surgery
    Keyvan Karkouti
    University Health Network, Toronto General Hospital, Department of Anesthesia, EN 3 402, 200 Elizabeth St, Toronto, Ontario, Canada M5G 2C4
    Circulation 118:331-8. 2008
    ..This observational study sought to identify the off-label use pattern of recombinant activated factor VII (rFVIIa) in cardiac surgery and to identify predictors of its effectiveness and risk...
  13. ncbi The influence of baseline hemoglobin concentration on tolerance of anemia in cardiac surgery
    Keyvan Karkouti
    Department of Anesthesia, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Transfusion 48:666-72. 2008
    ..Nonetheless, "normal" Hb concentrations vary widely in the population, and this variability may influence patients' tolerance of acute anemia. This retrospective cohort study was carried out to test this hypothesis...
  14. ncbi Risk associated with preoperative anemia in cardiac surgery: a multicenter cohort study
    Keyvan Karkouti
    Department of Anesthesia, University Health Network, University of Toronto, Toronto, Ontario, Canada, M5G 2C4
    Circulation 117:478-84. 2008
    ..Whether preoperative anemia also is an independent risk factor for adverse outcomes after cardiac surgery, however, has not been fully elucidated...
  15. ncbi Low hematocrit during cardiopulmonary bypass is associated with increased risk of perioperative stroke in cardiac surgery
    Keyvan Karkouti
    Department of Anesthesia, University Health Network, Toronto, Ontario, Canada
    Ann Thorac Surg 80:1381-7. 2005
    ..The objective of this observational study was to evaluate the relationship between nadir hematocrit during CPB and perioperative stroke while adjusting for variables known to have an association with stroke and anemia...
  16. ncbi The role of recombinant factor VIIa in on-pump cardiac surgery: proceedings of the Canadian Consensus Conference
    Keyvan Karkouti
    University Health Network, Toronto General Hospital, Department of Anesthesia, Toronto, Ontario, Canada
    Can J Anaesth 54:573-82. 2007
    ..A Canadian Consensus Conference was convened to generate recommendations for rFVIIa use in on-pump cardiac surgery...
  17. ncbi Pro: Preoperative autologous blood donation has a role in cardiac surgery
    Keyvan Karkouti
    Department of Anesthesia and Perioperative Blood Conservation Program, University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Cardiothorac Vasc Anesth 17:121-5. 2003
  18. ncbi The risk-benefit profile of aprotinin versus tranexamic acid in cardiac surgery
    Keyvan Karkouti
    Department of Anesthesia, University of Toronto, and Toronto General Hospital, Toronto, ON, Canada M5G 2C4
    Anesth Analg 110:21-9. 2010
    ..It remains unclear whether its risk-benefit profile differs among low-, moderate-, and high-risk cardiac surgical patients...
  19. ncbi The independent association of massive blood loss with mortality in cardiac surgery
    Keyvan Karkouti
    Department of Anesthesia, University of Toronto, Toronto, Ontario, Canada
    Transfusion 44:1453-62. 2004
    ..The objective of this cohort study was to quantify the independent association of MBL in cardiac surgery with all-cause in-hospital mortality...
  20. ncbi Influence of erythrocyte transfusion on the risk of acute kidney injury after cardiac surgery differs in anemic and nonanemic patients
    Keyvan Karkouti
    Department of Anesthesia, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Anesthesiology 115:523-30. 2011
    ..Two important risk factors for AKI are preoperative anemia and perioperative erythrocyte transfusion, and elucidating their relationship may help in devising preventive strategies...
  21. ncbi A multivariable model for predicting the need for blood transfusion in patients undergoing first-time elective coronary bypass graft surgery
    K Karkouti
    Department of Anesthesia, University Health Network, Toronto General Hospital, Centre for Research in Women s Health, Ontario, Canada
    Transfusion 41:1193-203. 2001
    ..Multivariable analysis techniques were used in this study to develop a prediction rule for such a purpose...
  22. ncbi Hemodilution during cardiopulmonary bypass is an independent risk factor for acute renal failure in adult cardiac surgery
    K Karkouti
    Department of Anesthesia, University Health Network, University of Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 129:391-400. 2005
    ..This observational study sought to determine whether the degree of hemodilution during cardiopulmonary bypass is independently related to perioperative acute renal failure necessitating dialysis support...
  23. ncbi Erythropoietin is an effective clinical modality for reducing RBC transfusion in joint surgery
    Keyvan Karkouti
    Department of Anesthesia, Unversity Health Network, University of Toronto, Ontario, Canada
    Can J Anaesth 52:362-8. 2005
    ..The purpose of this observational, cohort study was to assess the effectiveness of this practice in reducing red blood cell (RBC) transfusion...
  24. ncbi The incremental value of thrombelastography for prediction of excessive blood loss after cardiac surgery: an observational study
    Marcin Wasowicz
    Toronto General Hospital, 200 Elizabeth St, 3EN 402 Toronto, ON, Canada M5G 2C4
    Anesth Analg 111:331-8. 2010
    ..Accurate risk stratification may help reduce the burden of excessive blood loss after cardiac surgery. We measured the incremental value of thrombelastography to an existing risk prediction model for excessive blood loss in cardiac surgery...
  25. ncbi Derivation of a risk index for the prediction of massive blood transfusion in liver transplantation
    Stuart A McCluskey
    Department of Anesthesia and Pain Management, University of Toronto, Toronto, Ontario, Canada
    Liver Transpl 12:1584-93. 2006
    ..The ROC for this risk index was 0.79. MBT in liver transplantation surgery can be accurately predicted by 7 readily available preoperative predictors...
  26. ncbi The influence of perioperative coagulation status on postoperative blood loss in complex cardiac surgery: a prospective observational study
    Keyvan Karkouti
    Department of Anesthesia, Toronto General Hospital, 200 Elizabeth St, EN3 402, Toronto, ON, Canada M5G 2C4
    Anesth Analg 110:1533-40. 2010
    ..In this prospective cohort study, we measured patients' coagulation status before and after cardiopulmonary bypass (CPB) and examined their relationships with postoperative blood loss...
  27. ncbi Acute surgical anemia influences the cardioprotective effects of beta-blockade: a single-center, propensity-matched cohort study
    W Scott Beattie
    Department of Health Policy Management and Evaluation, University of Toronto, Toronto, Ontario, Canada
    Anesthesiology 112:25-33. 2010
    ....
  28. ncbi Evaluating surrogate measures of renal dysfunction after cardiac surgery
    Duminda N Wijeysundera
    Department of Anaesthesia, University of Toronto, Ontario, Canada
    Anesth Analg 96:1265-73, table of contents. 2003
    ..Both measures were correlated with clinical outcomes. Creatinine clearance had the advantage of a distribution suitable for parametric statistical tests...
  29. ncbi Recombinant factor VIIa for intractable blood loss after cardiac surgery: a propensity score-matched case-control analysis
    Keyvan Karkouti
    Department of Anesthesia, University of Toronto, University Health Network, Toronto, Ontario, Canada
    Transfusion 45:26-34. 2005
    ..Recombinant factor VIIa (rF-VIIa) is being increasingly used as rescue therapy in such cases, but little information is available on its safety and efficacy for this indication...
  30. ncbi Improving the identification of patients at risk of postoperative renal failure after cardiac surgery
    Duminda N Wijeysundera
    Department of Anesthesia, Toronto General Hospital and University of Toronto, Ontario, Canada
    Anesthesiology 104:65-72. 2006
    ..Calculated creatinine clearance (CrCl) is an alternative measure of renal function that may allow better estimation of renal reserve...
  31. ncbi Advance targeted transfusion in anemic cardiac surgical patients for kidney protection: an unblinded randomized pilot clinical trial
    Keyvan Karkouti
    Department of Anesthesia and Institute of Health Policy, Management, and Evaluation, University of Toronto, Toronto, Ontario, Canada
    Anesthesiology 116:613-21. 2012
    ..Prophylactic erythrocyte transfusion in anemic patients may, therefore, protect against AKI...
  32. ncbi N-acetylcysteine is associated with increased blood loss and blood product utilization during cardiac surgery
    Duminda N Wijeysundera
    Department of Anesthesia, Toronto General Hospital and University of Toronto, Toronto, Ontario, Canada
    Crit Care Med 37:1929-34. 2009
    ..We, therefore, performed a post hoc analysis of a recent randomized controlled trial in cardiac surgery to determine whether N-acetylcysteine was associated with increased blood loss and blood product transfusion...
  33. ncbi Acupressure wristbands for the prevention of postoperative nausea and vomiting in adults undergoing cardiac surgery
    Andrew A Klein
    Department of Anesthesia, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Cardiothorac Vasc Anesth 18:68-71. 2004
    ..CONCLUSION: Acupressure treatment did not lead to a reduction in nausea, vomiting, or antiemetic requirements in patients after cardiac surgery...
  34. ncbi The clinical utility of an index of global oxygenation for guiding red blood cell transfusion in cardiac surgery
    David Orlov
    Faculty of Medicine, Department of Anesthesia, Toronto General Hospital, Toronto, Ontario, Canada
    Transfusion 49:682-8. 2009
    ....
  35. ncbi The pharmacokinetic profile of recombinant human erythropoietin is unchanged in patients undergoing cardiac surgery
    Stuart A McCluskey
    Department of Anesthesia and Pain Management, Toronto General Hospital, University Health Network, Eaton North 3 405, 200 Elizabeth Street, Toronto, ON M5G 2C4, Canada
    Eur J Clin Pharmacol 65:273-9. 2009
    ..In anticipation of future studies, we examined the pharmacokinetics profile of erythropoietin (EPO) in patients undergoing cardiac surgery...
  36. ncbi N-acetylcysteine to reduce renal failure after cardiac surgery: a systematic review and meta-analysis
    Finola Naughton
    Department of Anesthesia and Pain Management, University Health Network, Toronto General Hospital, University of Toronto, Ontario, Canada
    Can J Anaesth 55:827-35. 2008
    ..To assess the effect of N-acetylcysteine (NAC) on acute renal failure and important clinical outcomes after cardiac surgery...
  37. ncbi Off-pump coronary artery surgery for reducing mortality and morbidity: meta-analysis of randomized and observational studies
    Duminda N Wijeysundera
    Department of Anesthesia, Toronto General Hospital, Toronto, Ontario, Canada
    J Am Coll Cardiol 46:872-82. 2005
    ..The purpose of this study was to assess the effects of off-pump coronary bypass surgery (OPCAB) on mortality and morbidity...
  38. ncbi Derivation and validation of a simplified predictive index for renal replacement therapy after cardiac surgery
    Duminda N Wijeysundera
    Department of Anesthesia, Toronto General Hospital and University of Toronto, Toronto, Ontario, Canada
    JAMA 297:1801-9. 2007
    ..A predictive index for renal replacement therapy (RRT; hemodialysis or continuous venovenous hemodiafiltration) after cardiac surgery may improve clinical decision making and research design...
  39. ncbi Calcium antagonists are associated with reduced mortality after cardiac surgery: a propensity analysis
    Duminda N Wijeysundera
    Department of Anesthesia, University of Toronto, EN 3-453, Toronto General Hospital, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada
    J Thorac Cardiovasc Surg 127:755-62. 2004
    ..This benefit also extends to the subgroup that underwent coronary artery bypass grafting. A large randomized controlled trial of perioperative calcium channel blockers is therefore warranted...
  40. ncbi Mild to moderate atheromatous disease of the thoracic aorta and new ischemic brain lesions after conventional coronary artery bypass graft surgery
    George Djaiani
    Department of Anesthesiology, Toronto General Hospital, University Health Network, University of Toronto, Canada
    Stroke 35:e356-8. 2004
    ..We sought to determine the role of proximal thoracic aortic atheroma in predicting embolic events and new ischemic brain lesions in patients undergoing conventional coronary revascularization surgery...
  41. ncbi The utility of thromboelastography for guiding recombinant activated factor VII therapy for refractory hemorrhage after cardiac surgery
    Marcin Wasowicz
    Department of Anesthesia, Toronto General Hospital, Toronto, Ontario, Canada
    J Cardiothorac Vasc Anesth 23:828-34. 2009
    ..In this study, the authors assessed the ability of thromboelastography (TEG) in guiding rFVIIa therapy in this setting...
  42. ncbi Risk associated with preoperative anemia in noncardiac surgery: a single-center cohort study
    W Scott Beattie
    Department of Anesthesia, University Health Network, Toronto General Hospital, Toronto, Ontario, Canada
    Anesthesiology 110:574-81. 2009
    ..The objective of this observational study was to measure the prevalence of preoperative anemia and assess the relationship between preoperative anemia and postoperative mortality...
  43. ncbi The safety of perioperative esmolol: a systematic review and meta-analysis of randomized controlled trials
    Savio K H Yu
    Department of Anesthesia and Pain Management, University Health Network, of Toronto, Toronto, Ontario, M5G 2C4, Canada
    Anesth Analg 112:267-81. 2011
    ..Safety was assessed by analyzing the incidence of postoperative hypotension and bradycardia, and efficacy was assessed by analyzing the incidence of myocardial ischemia...
  44. ncbi Does tight heart rate control improve beta-blocker efficacy? An updated analysis of the noncardiac surgical randomized trials
    W Scott Beattie
    Department of Anesthesia, Toronto General Hospital and University of Toronto, EN 3 450 200 Elizabeth St, Toronto, Ontario M5G 2C4, Canada
    Anesth Analg 106:1039-48, table of contents. 2008
    ..Tight control of heart rate (HR) has been suggested to improve these outcomes. Meta-analyses have not considered the influence of tight HR control on the efficacy of perioperative beta-blockade...
  45. ncbi Association of echocardiography before major elective non-cardiac surgery with postoperative survival and length of hospital stay: population based cohort study
    Duminda N Wijeysundera
    Keenan Research Centre, Li Ka Shing Knowledge Institute of St Michael s Hospital, 80 Bond Street, Toronto, ON, Canada
    BMJ 342:d3695. 2011
    ..To determine the association of resting echocardiography before elective intermediate to high risk non-cardiac surgery with survival and length of hospital stay...
  46. ncbi A cluster-randomized controlled trial of a blood conservation algorithm in patients undergoing total hip joint arthroplasty
    Cindy J Wong
    Robarts Research Institute, Department of Epidemiology and Biostatistics, University of Western Ontario, London, Ontario, Canada
    Transfusion 47:832-41. 2007
    ..The optimum strategy for reducing allogeneic blood transfusion in patients undergoing total hip joint arthroplasty (THJA) is unknown...
  47. ncbi Dual antiplatelet therapy in patients requiring urgent coronary artery bypass grafting surgery: a position statement of the Canadian Cardiovascular Society
    David Fitchett
    St Michael s Hospital, Toronto, Canada
    Can J Cardiol 25:683-9. 2009
    ..Clopidogrel should be restarted when hemostasis is assured to prevent recurrent acute ischemic events...
  48. ncbi Hyperglycemia during cardiopulmonary bypass is an independent risk factor for mortality in patients undergoing cardiac surgery
    Torsten Doenst
    Division of Cardiovascular Surgery, Toronto General Hospital and University of Toronto, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 130:1144. 2005
    ..3) or aortic crossclamp times (r = 0.4). CONCLUSIONS: A high peak serum glucose level during cardiopulmonary bypass is an independent risk factor for death and morbidity in diabetic patients and unexpectedly also in nondiabetic patients...
  49. ncbi Case report: management of life-threatening oropharyngeal bleeding with recombinant factor VIIa
    Sheila Riazi
    Toronto General Hospital, University Health Network, Department of Anesthesia, Toronto, Ontario, Canada
    Can J Anaesth 53:881-4. 2006
    ....
  50. ncbi Risk factors for major complications after extrapleural pneumonectomy for malignant pleural mesothelioma
    Marc de Perrot
    Division of Thoracic Surgery, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada
    Ann Thorac Surg 85:1206-10. 2008
    ....
  51. ncbi Use of clinically based troponin underestimates the cardiac injury in non-cardiac surgery: a single-centre cohort study in 51,701 consecutive patients
    W Scott Beattie
    Department of Anesthesia and Pain Management, University Health Network, Toronto, ON, Canada
    Can J Anaesth 59:1013-22. 2012
    ....
  52. ncbi Technical report: analysis of citrated blood with thromboelastography: comparison with fresh blood samples
    Marcin Wasowicz
    Department of Anesthesia, Toronto General Hospital, University Health Network, and Department of Health Policy, Management and Evaluation, University of Toronto, 200 Elizabeth St, EN3 424, Toronto, Ontario M5G 2C4, Canada
    Can J Anaesth 55:284-9. 2008
    ....
  53. ncbi Case report: transfusion-related acute lung injury (TRALI) - a clear and present danger
    Yulia Lin
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Can J Anaesth 54:1011-6. 2007
    ....
  54. ncbi Cryoprecipitate: the current state of knowledge
    Jeannie L Callum
    Sunnybrook Health Sciences Centre and University Health Network, Toronto, Ontario, Canada
    Transfus Med Rev 23:177-88. 2009
    ..Despite 45 years of the use of this product, we still have a lot to learn regarding the optimal use of cryoprecipitate...
  55. ncbi Relationship of erythrocyte transfusion with short- and long-term mortality in a population-based surgical cohort
    Keyvan Karkouti
    Department of Anesthesia, Toronto General Hospital, University Health Network, Institute of Health Policy, Management, and Evaluation, University of Toronto, Toronto, Ontario, Canada
    Anesthesiology 117:1175-83. 2012
    ..Nonetheless, unmeasured confounding may unduly influence this comparison. This unmeasured risk may have less influence on comparisons of patients undergoing surgery at hospitals with differing transfusion rates...
  56. ncbi Con: Aprotinin has a good efficacy and safety profile relative to other alternatives for prevention of bleeding in cardiac surgery
    W Scott Beattie
    Anesth Analg 103:1360-4. 2006
  57. ncbi Letter by Karkouti and Beattie regarding article "Aprotinin does not increase the risk of renal failure in cardiac surgery patients"
    Keyvan Karkouti
    Circulation 117:e472; author reply e476. 2008
  58. ncbi Case 6--2007: massive intraoperative thrombosis and death after recombinant activated factor VII administration
    Adam D Lichtman
    Department of Anesthesiology, Weill-Cornell Medical Center, New York, NY 10021, USA
    J Cardiothorac Vasc Anesth 21:897-902. 2007
  59. ncbi Transfusion practices for elective orthopedic surgery
    Brian G Feagan
    Department of Epidemiology and Biostatistics, London Clinical Trials Research Group, John P. Robarts Research Institute, Ont
    CMAJ 166:310-4. 2002
    ..4% of all cases). INTERPRETATION: The use of blood conservation techniques among hospitals in Canada remains low. Only a minority of eligible patients participated in an autologous blood donation program...
  60. ncbi Pulmonary-artery catheters in high-risk surgical patients
    Keyvan Karkouti
    N Engl J Med 348:2035-7; author reply 2035-7. 2003
  61. ncbi Blood transfusions and mortality among critically ill patients
    Keyvan Karkouti
    JAMA 289:1242. 2003
  62. ncbi Perioperative blood conservation--the experts, the elephants, the clinicians, and the gauntlet
    Keyvan Karkouti
    Can J Anaesth 54:861-7. 2007
  63. ncbi Platelet transfusions as a risk factor in cardiac surgery
    Keyvan Karkouti
    Transfusion 47:1739-40; author reply 1740. 2007