Keyvan Karkouti

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. doi request reprint Comprehensive Canadian review of the off-label use of recombinant activated factor VII in cardiac surgery
    Keyvan Karkouti
    University Health Network, Toronto General Hospital, Department of Anesthesia, EN 3 402, 200 Elizabeth St, Toronto, Ontario, Canada M5G 2C4
    Circulation 118:331-8. 2008
  2. ncbi request reprint Intravenous iron and recombinant erythropoietin for the treatment of postoperative anemia
    Keyvan Karkouti
    Toronto General Hospital, University Health Network, Department of Anesthesia, 3 Eaton North, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada
    Can J Anaesth 53:11-9. 2006
  3. ncbi request reprint Platelet transfusions are not associated with increased morbidity or mortality in cardiac surgery
    Keyvan Karkouti
    Department of Anesthesia, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Can J Anaesth 53:279-87. 2006
  4. ncbi request reprint A propensity score case-control comparison of aprotinin and tranexamic acid in high-transfusion-risk cardiac surgery
    Keyvan Karkouti
    Department of Anesthesia, University of Toronto, Toronto, Ontario, Canada
    Transfusion 46:327-38. 2006
  5. doi request reprint Acute kidney injury after cardiac surgery: focus on modifiable risk factors
    Keyvan Karkouti
    Department of Anesthesia and Health Policy, Management, and Evaluation, Toronto General Hospital, University of Toronto, 200 Elizabeth St, EN 3 402, Toronto, Ontario, Canada M5G 2C4
    Circulation 119:495-502. 2009
  6. ncbi request reprint Aprotinin is useful as a hemostatic agent in cardiopulmonary surgery: no
    K Karkouti
    Department of Anesthesia, Health Network, University of Toronto, Toronto, ON, Canada
    J Thromb Haemost 4:1879-81. 2006
  7. ncbi request reprint Prediction of massive blood transfusion in cardiac surgery
    Keyvan Karkouti
    University Health Network, Toronto General Hospital, Department of Anesthesia, EN 3 402, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada
    Can J Anaesth 53:781-94. 2006
  8. ncbi request reprint Determinants of complications with recombinant factor VIIa for refractory blood loss in cardiac surgery
    Keyvan Karkouti
    University of Toronto, University Health Network, Department of Anesthesia, 3 Eaton North, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada
    Can J Anaesth 53:802-9. 2006
  9. ncbi request reprint The effects of a treatment protocol for cardiac surgical patients with excessive blood loss on clinical outcomes
    K Karkouti
    Department of Anaesthesia, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Vox Sang 91:148-56. 2006
  10. doi request reprint Influence of erythrocyte transfusion on the risk of acute kidney injury after cardiac surgery differs in anemic and nonanemic patients
    Keyvan Karkouti
    Department of Anesthesia, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Anesthesiology 115:523-30. 2011

Detail Information

Publications69

  1. doi request reprint Comprehensive Canadian review of the off-label use of recombinant activated factor VII in cardiac surgery
    Keyvan Karkouti
    University Health Network, Toronto General Hospital, Department of Anesthesia, EN 3 402, 200 Elizabeth St, Toronto, Ontario, Canada M5G 2C4
    Circulation 118:331-8. 2008
    ..This observational study sought to identify the off-label use pattern of recombinant activated factor VII (rFVIIa) in cardiac surgery and to identify predictors of its effectiveness and risk...
  2. ncbi request reprint Intravenous iron and recombinant erythropoietin for the treatment of postoperative anemia
    Keyvan Karkouti
    Toronto General Hospital, University Health Network, Department of Anesthesia, 3 Eaton North, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada
    Can J Anaesth 53:11-9. 2006
    ..To determine if early recovery from severe post-operative anemia is accelerated by iv iron therapy alone or in combination with recombinant erythropoietin (EPO)...
  3. ncbi request reprint Platelet transfusions are not associated with increased morbidity or mortality in cardiac surgery
    Keyvan Karkouti
    Department of Anesthesia, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Can J Anaesth 53:279-87. 2006
    ..To determine the independent relationship between leukoreduced platelet transfusions and adverse events in cardiac surgery...
  4. ncbi request reprint A propensity score case-control comparison of aprotinin and tranexamic acid in high-transfusion-risk cardiac surgery
    Keyvan Karkouti
    Department of Anesthesia, University of Toronto, Toronto, Ontario, Canada
    Transfusion 46:327-38. 2006
    ..Prophylactic use of the antifibrinolytic drugs aprotinin and tranexamic acid is thought to prevent these hemostatic defects. Their relative clinical utility and safety in high-transfusion-risk cardiac surgery, however, is not known...
  5. doi request reprint Acute kidney injury after cardiac surgery: focus on modifiable risk factors
    Keyvan Karkouti
    Department of Anesthesia and Health Policy, Management, and Evaluation, Toronto General Hospital, University of Toronto, 200 Elizabeth St, EN 3 402, Toronto, Ontario, Canada M5G 2C4
    Circulation 119:495-502. 2009
    ..Lacking effective therapies, risk factor modification may offer a means of preventing this complication. The objective of the present study was to identify and determine the prognostic importance of such risk factors...
  6. ncbi request reprint Aprotinin is useful as a hemostatic agent in cardiopulmonary surgery: no
    K Karkouti
    Department of Anesthesia, Health Network, University of Toronto, Toronto, ON, Canada
    J Thromb Haemost 4:1879-81. 2006
  7. ncbi request reprint Prediction of massive blood transfusion in cardiac surgery
    Keyvan Karkouti
    University Health Network, Toronto General Hospital, Department of Anesthesia, EN 3 402, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada
    Can J Anaesth 53:781-94. 2006
    ..The objective of this study was to develop a prediction rule for massive blood transfusion (MBT) that could be used to optimize the management of, and research on, at-risk patients...
  8. ncbi request reprint Determinants of complications with recombinant factor VIIa for refractory blood loss in cardiac surgery
    Keyvan Karkouti
    University of Toronto, University Health Network, Department of Anesthesia, 3 Eaton North, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada
    Can J Anaesth 53:802-9. 2006
    ..Recombinant factor VIIa (rFVIIa) is being used for refractory, excessive blood loss (EBL) after cardiac surgery, but its safety for this indication is not known...
  9. ncbi request reprint The effects of a treatment protocol for cardiac surgical patients with excessive blood loss on clinical outcomes
    K Karkouti
    Department of Anaesthesia, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Vox Sang 91:148-56. 2006
    ..The objective of this before/after study was to determine whether the implementation of a protocol for management of cardiac surgical patients with EBL was associated with improved clinical outcomes...
  10. doi request reprint Influence of erythrocyte transfusion on the risk of acute kidney injury after cardiac surgery differs in anemic and nonanemic patients
    Keyvan Karkouti
    Department of Anesthesia, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Anesthesiology 115:523-30. 2011
    ..Two important risk factors for AKI are preoperative anemia and perioperative erythrocyte transfusion, and elucidating their relationship may help in devising preventive strategies...
  11. ncbi request reprint The role of recombinant factor VIIa in on-pump cardiac surgery: proceedings of the Canadian Consensus Conference
    Keyvan Karkouti
    University Health Network, Toronto General Hospital, Department of Anesthesia, Toronto, Ontario, Canada
    Can J Anaesth 54:573-82. 2007
    ..A Canadian Consensus Conference was convened to generate recommendations for rFVIIa use in on-pump cardiac surgery...
  12. doi request reprint The risk-benefit profile of aprotinin versus tranexamic acid in cardiac surgery
    Keyvan Karkouti
    Department of Anesthesia, University of Toronto, and Toronto General Hospital, Toronto, ON, Canada M5G 2C4
    Anesth Analg 110:21-9. 2010
    ..It remains unclear whether its risk-benefit profile differs among low-, moderate-, and high-risk cardiac surgical patients...
  13. ncbi request reprint Variability and predictability of large-volume red blood cell transfusion in cardiac surgery: a multicenter study
    Keyvan Karkouti
    University Health Network, Toronto General Hospital, Department of Anesthesia, Ontario, Canada
    Transfusion 47:2081-8. 2007
    ..The objectives of this study were to measure the interinstitution variation and predictability of large-volume RBC transfusion...
  14. doi request reprint Risk associated with preoperative anemia in cardiac surgery: a multicenter cohort study
    Keyvan Karkouti
    Department of Anesthesia, University Health Network, University of Toronto, Toronto, Ontario, Canada, M5G 2C4
    Circulation 117:478-84. 2008
    ..Whether preoperative anemia also is an independent risk factor for adverse outcomes after cardiac surgery, however, has not been fully elucidated...
  15. doi request reprint The influence of baseline hemoglobin concentration on tolerance of anemia in cardiac surgery
    Keyvan Karkouti
    Department of Anesthesia, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Transfusion 48:666-72. 2008
    ..Nonetheless, "normal" Hb concentrations vary widely in the population, and this variability may influence patients' tolerance of acute anemia. This retrospective cohort study was carried out to test this hypothesis...
  16. ncbi request reprint Prognostic value of postoperative proteinuria in cardiac surgery: a pilot study
    Keyvan Karkouti
    University Health Network, Toronto General Hospital, Department of Anesthesia, EN 3 402, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada
    Can J Anaesth 53:500-6. 2006
    ..The objective of this pilot study was to determine if postoperative proteinuria is associated with adverse outcomes following cardiac surgery with cardiopulmonary bypass...
  17. ncbi request reprint Low hematocrit during cardiopulmonary bypass is associated with increased risk of perioperative stroke in cardiac surgery
    Keyvan Karkouti
    Department of Anesthesia, University Health Network, Toronto, Ontario, Canada
    Ann Thorac Surg 80:1381-7. 2005
    ..The objective of this observational study was to evaluate the relationship between nadir hematocrit during CPB and perioperative stroke while adjusting for variables known to have an association with stroke and anemia...
  18. ncbi request reprint A multivariable model for predicting the need for blood transfusion in patients undergoing first-time elective coronary bypass graft surgery
    K Karkouti
    Department of Anesthesia, University Health Network, Toronto General Hospital, Centre for Research in Women s Health, Ontario, Canada
    Transfusion 41:1193-203. 2001
    ..Multivariable analysis techniques were used in this study to develop a prediction rule for such a purpose...
  19. ncbi request reprint Pro: Preoperative autologous blood donation has a role in cardiac surgery
    Keyvan Karkouti
    Department of Anesthesia and Perioperative Blood Conservation Program, University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Cardiothorac Vasc Anesth 17:121-5. 2003
  20. ncbi request reprint The independent association of massive blood loss with mortality in cardiac surgery
    Keyvan Karkouti
    Department of Anesthesia, University of Toronto, Toronto, Ontario, Canada
    Transfusion 44:1453-62. 2004
    ..The objective of this cohort study was to quantify the independent association of MBL in cardiac surgery with all-cause in-hospital mortality...
  21. ncbi request reprint Predicting difficult intubation: a multivariable analysis
    K Karkouti
    Department of Anaesthesia, Toronto General Hospital, University Health Network, Ontario, Canada
    Can J Anaesth 47:730-9. 2000
    ..To develop a clinically useful and valid model for predicting difficult laryngoscopic tracheal intubation in patients with seemingly normal airways by adhering to the principles of multivariable model development...
  22. ncbi request reprint Erythropoietin is an effective clinical modality for reducing RBC transfusion in joint surgery
    Keyvan Karkouti
    Department of Anesthesia, Unversity Health Network, University of Toronto, Ontario, Canada
    Can J Anaesth 52:362-8. 2005
    ..The purpose of this observational, cohort study was to assess the effectiveness of this practice in reducing red blood cell (RBC) transfusion...
  23. ncbi request reprint Hemodilution during cardiopulmonary bypass is an independent risk factor for acute renal failure in adult cardiac surgery
    K Karkouti
    Department of Anesthesia, University Health Network, University of Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 129:391-400. 2005
    ..This observational study sought to determine whether the degree of hemodilution during cardiopulmonary bypass is independently related to perioperative acute renal failure necessitating dialysis support...
  24. ncbi request reprint The incremental value of thrombelastography for prediction of excessive blood loss after cardiac surgery: an observational study
    Marcin Wasowicz
    Toronto General Hospital, 200 Elizabeth St, 3EN 402 Toronto, ON, Canada M5G 2C4
    Anesth Analg 111:331-8. 2010
    ..Accurate risk stratification may help reduce the burden of excessive blood loss after cardiac surgery. We measured the incremental value of thrombelastography to an existing risk prediction model for excessive blood loss in cardiac surgery...
  25. ncbi request reprint Derivation of a risk index for the prediction of massive blood transfusion in liver transplantation
    Stuart A McCluskey
    Department of Anesthesia and Pain Management, University of Toronto, Toronto, Ontario, Canada
    Liver Transpl 12:1584-93. 2006
    ..The ROC for this risk index was 0.79. MBT in liver transplantation surgery can be accurately predicted by 7 readily available preoperative predictors...
  26. ncbi request reprint The influence of perioperative coagulation status on postoperative blood loss in complex cardiac surgery: a prospective observational study
    Keyvan Karkouti
    Department of Anesthesia, Toronto General Hospital, 200 Elizabeth St, EN3 402, Toronto, ON, Canada M5G 2C4
    Anesth Analg 110:1533-40. 2010
    ..In this prospective cohort study, we measured patients' coagulation status before and after cardiopulmonary bypass (CPB) and examined their relationships with postoperative blood loss...
  27. doi request reprint Acute surgical anemia influences the cardioprotective effects of beta-blockade: a single-center, propensity-matched cohort study
    W Scott Beattie
    Department of Health Policy Management and Evaluation, University of Toronto, Toronto, Ontario, Canada
    Anesthesiology 112:25-33. 2010
    ....
  28. ncbi request reprint Evaluating surrogate measures of renal dysfunction after cardiac surgery
    Duminda N Wijeysundera
    Department of Anaesthesia, University of Toronto, Ontario, Canada
    Anesth Analg 96:1265-73, table of contents. 2003
    ..Mathematical transformation of DeltaCr(72h) to %DeltaCrCl(72h) results in a normal distribution that is amenable to parametric statistical tests. DeltaCr(72h) and %DeltaCrCl(72h) may be used as surrogate outcomes in future trials...
  29. doi request reprint The relationship between fibrinogen levels after cardiopulmonary bypass and large volume red cell transfusion in cardiac surgery: an observational study
    Keyvan Karkouti
    Department of Anesthesia, Toronto General Hospital, 3EN, Toronto, ON, M5G 2C4, Canada
    Anesth Analg 117:14-22. 2013
    ..We explored the relationship between post-CPB fibrinogen levels and large volume red cell transfusion...
  30. ncbi request reprint Recombinant factor VIIa for intractable blood loss after cardiac surgery: a propensity score-matched case-control analysis
    Keyvan Karkouti
    Department of Anesthesia, University of Toronto, University Health Network, Toronto, Ontario, Canada
    Transfusion 45:26-34. 2005
    ..Recombinant factor VIIa (rF-VIIa) is being increasingly used as rescue therapy in such cases, but little information is available on its safety and efficacy for this indication...
  31. ncbi request reprint Improving the identification of patients at risk of postoperative renal failure after cardiac surgery
    Duminda N Wijeysundera
    Department of Anesthesia, Toronto General Hospital and University of Toronto, Ontario, Canada
    Anesthesiology 104:65-72. 2006
    ..Calculated creatinine clearance (CrCl) is an alternative measure of renal function that may allow better estimation of renal reserve...
  32. doi request reprint Platelet dysfunction as measured by a point-of-care monitor is an independent predictor of high blood loss in cardiac surgery
    David Orlov
    From the Departments of Anesthesia and Pain Management, Laboratory Medicine, Clinical Biochemistry, and the Toronto General Research Institute, Toronto General Hospital, University Health Network, University of Toronto, and Institute of Health Policy, Management, and Evaluation, University of Toronto, Toronto, Ontario, Canada
    Anesth Analg 118:257-63. 2014
    ..Although platelet dysfunction is considered to be an important cause, it is not routinely measured. Our objective was to explore the relationship between platelet dysfunction and blood loss in cardiac surgery...
  33. doi request reprint Advance targeted transfusion in anemic cardiac surgical patients for kidney protection: an unblinded randomized pilot clinical trial
    Keyvan Karkouti
    Department of Anesthesia and Institute of Health Policy, Management, and Evaluation, University of Toronto, Toronto, Ontario, Canada
    Anesthesiology 116:613-21. 2012
    ..Prophylactic erythrocyte transfusion in anemic patients may, therefore, protect against AKI...
  34. doi request reprint Hyperchloremia after noncardiac surgery is independently associated with increased morbidity and mortality: a propensity-matched cohort study
    Stuart A McCluskey
    Department of Anesthesia and Pain Management, Toronto General Hospital, University Health Network, 200 Elizabeth St, EN 3 405, Toronto, Ontario M5G 2C4, Canada
    Anesth Analg 117:412-21. 2013
    ....
  35. doi request reprint Use of clinically based troponin underestimates the cardiac injury in non-cardiac surgery: a single-centre cohort study in 51,701 consecutive patients
    W Scott Beattie
    Department of Anesthesia and Pain Management, University Health Network, Toronto, ON, Canada
    Can J Anaesth 59:1013-22. 2012
    ....
  36. ncbi request reprint Acupressure wristbands for the prevention of postoperative nausea and vomiting in adults undergoing cardiac surgery
    Andrew A Klein
    Department of Anesthesia, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Cardiothorac Vasc Anesth 18:68-71. 2004
    ..To determine whether the application of acupressure bands would lead to a reduction in postoperative nausea and vomiting after cardiac surgery...
  37. doi request reprint N-acetylcysteine is associated with increased blood loss and blood product utilization during cardiac surgery
    Duminda N Wijeysundera
    Department of Anesthesia, Toronto General Hospital and University of Toronto, Toronto, Ontario, Canada
    Crit Care Med 37:1929-34. 2009
    ..We, therefore, performed a post hoc analysis of a recent randomized controlled trial in cardiac surgery to determine whether N-acetylcysteine was associated with increased blood loss and blood product transfusion...
  38. doi request reprint Efficacy and safety of recombinant factor XIII on reducing blood transfusions in cardiac surgery: a randomized, placebo-controlled, multicenter clinical trial
    Keyvan Karkouti
    Department of Anesthesia and the Toronto General Research Institute, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada Electronic address
    J Thorac Cardiovasc Surg 146:927-39. 2013
    ..Because low factor XIII (FXIII) levels have been associated with bleeding after cardiac surgery, we investigated whether administering recombinant FXIII after cardiopulmonary bypass would reduce transfusions...
  39. ncbi request reprint The clinical utility of an index of global oxygenation for guiding red blood cell transfusion in cardiac surgery
    David Orlov
    Faculty of Medicine, Department of Anesthesia, Toronto General Hospital, Toronto, Ontario, Canada
    Transfusion 49:682-8. 2009
    ....
  40. ncbi request reprint Off-pump coronary artery surgery for reducing mortality and morbidity: meta-analysis of randomized and observational studies
    Duminda N Wijeysundera
    Department of Anesthesia, Toronto General Hospital, Toronto, Ontario, Canada
    J Am Coll Cardiol 46:872-82. 2005
    ..The purpose of this study was to assess the effects of off-pump coronary bypass surgery (OPCAB) on mortality and morbidity...
  41. ncbi request reprint N-acetylcysteine to reduce renal failure after cardiac surgery: a systematic review and meta-analysis
    Finola Naughton
    Department of Anesthesia and Pain Management, University Health Network, Toronto General Hospital, University of Toronto, Ontario, Canada
    Can J Anaesth 55:827-35. 2008
    ..To assess the effect of N-acetylcysteine (NAC) on acute renal failure and important clinical outcomes after cardiac surgery...
  42. doi request reprint The pharmacokinetic profile of recombinant human erythropoietin is unchanged in patients undergoing cardiac surgery
    Stuart A McCluskey
    Department of Anesthesia and Pain Management, Toronto General Hospital, University Health Network, Eaton North 3 405, 200 Elizabeth Street, Toronto, ON M5G 2C4, Canada
    Eur J Clin Pharmacol 65:273-9. 2009
    ..In anticipation of future studies, we examined the pharmacokinetics profile of erythropoietin (EPO) in patients undergoing cardiac surgery...
  43. ncbi request reprint Calcium antagonists are associated with reduced mortality after cardiac surgery: a propensity analysis
    Duminda N Wijeysundera
    Department of Anesthesia, University of Toronto, EN 3 453, Toronto General Hospital, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada
    J Thorac Cardiovasc Surg 127:755-62. 2004
    ..We therefore performed a prospective observational cohort study of the effects of calcium channel blockers on cardiac surgical mortality. A propensity score technique was used for risk adjustment...
  44. ncbi request reprint Mild to moderate atheromatous disease of the thoracic aorta and new ischemic brain lesions after conventional coronary artery bypass graft surgery
    George Djaiani
    Department of Anesthesiology, Toronto General Hospital, University Health Network, University of Toronto, Canada
    Stroke 35:e356-8. 2004
    ..We sought to determine the role of proximal thoracic aortic atheroma in predicting embolic events and new ischemic brain lesions in patients undergoing conventional coronary revascularization surgery...
  45. ncbi request reprint Derivation and validation of a simplified predictive index for renal replacement therapy after cardiac surgery
    Duminda N Wijeysundera
    Department of Anesthesia, Toronto General Hospital and University of Toronto, Toronto, Ontario, Canada
    JAMA 297:1801-9. 2007
    ..A predictive index for renal replacement therapy (RRT; hemodialysis or continuous venovenous hemodiafiltration) after cardiac surgery may improve clinical decision making and research design...
  46. doi request reprint The utility of thromboelastography for guiding recombinant activated factor VII therapy for refractory hemorrhage after cardiac surgery
    Marcin Wasowicz
    Department of Anesthesia, Toronto General Hospital, Toronto, Ontario, Canada
    J Cardiothorac Vasc Anesth 23:828-34. 2009
    ..In this study, the authors assessed the ability of thromboelastography (TEG) in guiding rFVIIa therapy in this setting...
  47. doi request reprint The safety of perioperative esmolol: a systematic review and meta-analysis of randomized controlled trials
    Savio K H Yu
    Department of Anesthesia and Pain Management, University Health Network, of Toronto, Toronto, Ontario, M5G 2C4, Canada
    Anesth Analg 112:267-81. 2011
    ..Safety was assessed by analyzing the incidence of postoperative hypotension and bradycardia, and efficacy was assessed by analyzing the incidence of myocardial ischemia...
  48. ncbi request reprint Risk associated with preoperative anemia in noncardiac surgery: a single-center cohort study
    W Scott Beattie
    Department of Anesthesia, University Health Network, Toronto General Hospital, Toronto, Ontario, Canada
    Anesthesiology 110:574-81. 2009
    ..The objective of this observational study was to measure the prevalence of preoperative anemia and assess the relationship between preoperative anemia and postoperative mortality...
  49. doi request reprint Does tight heart rate control improve beta-blocker efficacy? An updated analysis of the noncardiac surgical randomized trials
    W Scott Beattie
    Department of Anesthesia, Toronto General Hospital and University of Toronto, EN 3 450 200 Elizabeth St, Toronto, Ontario M5G 2C4, Canada
    Anesth Analg 106:1039-48, table of contents. 2008
    ..Tight control of heart rate (HR) has been suggested to improve these outcomes. Meta-analyses have not considered the influence of tight HR control on the efficacy of perioperative beta-blockade...
  50. ncbi request reprint Case report: management of life-threatening oropharyngeal bleeding with recombinant factor VIIa
    Sheila Riazi
    Toronto General Hospital, University Health Network, Department of Anesthesia, Toronto, Ontario, Canada
    Can J Anaesth 53:881-4. 2006
    ..To report the use of recombinant factor VIIa (rFVIIa) for management of profuse oropharyngeal bleeding in a cirrhotic patient that nearly resulted in a 'cannot intubate, cannot ventilate' scenario...
  51. pmc Association of echocardiography before major elective non-cardiac surgery with postoperative survival and length of hospital stay: population based cohort study
    Duminda N Wijeysundera
    Keenan Research Centre, Li Ka Shing Knowledge Institute of St Michael s Hospital, 80 Bond Street, Toronto, ON, Canada
    BMJ 342:d3695. 2011
    ..To determine the association of resting echocardiography before elective intermediate to high risk non-cardiac surgery with survival and length of hospital stay...
  52. ncbi request reprint A cluster-randomized controlled trial of a blood conservation algorithm in patients undergoing total hip joint arthroplasty
    Cindy J Wong
    Robarts Research Institute, Department of Epidemiology and Biostatistics, University of Western Ontario, London, Ontario, Canada
    Transfusion 47:832-41. 2007
    ..The optimum strategy for reducing allogeneic blood transfusion in patients undergoing total hip joint arthroplasty (THJA) is unknown...
  53. doi request reprint Seek and you shall find--but then what do you do? Cold agglutinins in cardiopulmonary bypass and a single-center experience with cold agglutinin screening before cardiac surgery
    Michael D Jain
    University of Toronto, Toronto, Ontario, Canada
    Transfus Med Rev 27:65-73. 2013
    ..Based upon historical and local data, preclinical CAS is cost-substantial and nonspecific. Cold agglutinin screening does not promote an algorithm of care that meaningfully improves patient CPB outcomes...
  54. doi request reprint Relationship of erythrocyte transfusion with short- and long-term mortality in a population-based surgical cohort
    Keyvan Karkouti
    Department of Anesthesia, Toronto General Hospital, University Health Network, Institute of Health Policy, Management, and Evaluation, University of Toronto, Toronto, Ontario, Canada
    Anesthesiology 117:1175-83. 2012
    ..Nonetheless, unmeasured confounding may unduly influence this comparison. This unmeasured risk may have less influence on comparisons of patients undergoing surgery at hospitals with differing transfusion rates...
  55. pmc Dual antiplatelet therapy in patients requiring urgent coronary artery bypass grafting surgery: a position statement of the Canadian Cardiovascular Society
    David Fitchett
    St Michael s Hospital, Toronto, Canada
    Can J Cardiol 25:683-9. 2009
    ..Clopidogrel should be restarted when hemostasis is assured to prevent recurrent acute ischemic events...
  56. ncbi request reprint Hyperglycemia during cardiopulmonary bypass is an independent risk factor for mortality in patients undergoing cardiac surgery
    Torsten Doenst
    Division of Cardiovascular Surgery, Toronto General Hospital and University of Toronto, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 130:1144. 2005
    ..We assessed the influence of hyperglycemia (highest glucose level) during cardiopulmonary bypass on perioperative morbidity and mortality in diabetic and nondiabetic patients...
  57. doi request reprint Risk factors for major complications after extrapleural pneumonectomy for malignant pleural mesothelioma
    Marc de Perrot
    Division of Thoracic Surgery, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada
    Ann Thorac Surg 85:1206-10. 2008
    ....
  58. doi request reprint The rationale for platelet transfusion during cardiopulmonary bypass: an observational study
    Nusrat Zaffar
    St Michael s Hospital, Toronto, ON, Canada
    Can J Anaesth 60:345-54. 2013
    ..The objectives of this study were to determine the factors that influenced physicians' decisions to transfuse platelets perioperatively and to determine whether these factors coincide with characteristics using chart abstraction...
  59. doi request reprint Technical report: analysis of citrated blood with thromboelastography: comparison with fresh blood samples
    Marcin Wasowicz
    Department of Anesthesia, Toronto General Hospital, University Health Network, and Department of Health Policy, Management and Evaluation, University of Toronto, 200 Elizabeth St, EN3 424, Toronto, Ontario M5G 2C4, Canada
    Can J Anaesth 55:284-9. 2008
    ....
  60. ncbi request reprint Case report: transfusion-related acute lung injury (TRALI) - a clear and present danger
    Yulia Lin
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Can J Anaesth 54:1011-6. 2007
    ....
  61. ncbi request reprint Cryoprecipitate: the current state of knowledge
    Jeannie L Callum
    Sunnybrook Health Sciences Centre and University Health Network, Toronto, Ontario, Canada
    Transfus Med Rev 23:177-88. 2009
    ..Despite 45 years of the use of this product, we still have a lot to learn regarding the optimal use of cryoprecipitate...
  62. doi request reprint Letter by Karkouti and Beattie regarding article "Aprotinin does not increase the risk of renal failure in cardiac surgery patients"
    Keyvan Karkouti
    Circulation 117:e472; author reply e476. 2008
  63. ncbi request reprint Con: Aprotinin has a good efficacy and safety profile relative to other alternatives for prevention of bleeding in cardiac surgery
    W Scott Beattie
    Anesth Analg 103:1360-4. 2006
  64. pmc Transfusion practices for elective orthopedic surgery
    Brian G Feagan
    Department of Epidemiology and Biostatistics, London Clinical Trials Research Group, John P Robarts Research Institute, Ont
    CMAJ 166:310-4. 2002
    ..We examined the transfusion practice and blood conservation strategies for elective orthopedic procedures in 19 Canadian hospitals...
  65. ncbi request reprint Case 6--2007: massive intraoperative thrombosis and death after recombinant activated factor VII administration
    Adam D Lichtman
    Department of Anesthesiology, Weill Cornell Medical Center, New York, NY 10021, USA
    J Cardiothorac Vasc Anesth 21:897-902. 2007
  66. ncbi request reprint Platelet transfusions as a risk factor in cardiac surgery
    Keyvan Karkouti
    Transfusion 47:1739-40; author reply 1740. 2007
  67. ncbi request reprint Pulmonary-artery catheters in high-risk surgical patients
    Keyvan Karkouti
    N Engl J Med 348:2035-7; author reply 2035-7. 2003
  68. ncbi request reprint Blood transfusions and mortality among critically ill patients
    Keyvan Karkouti
    JAMA 289:1242. 2003
  69. ncbi request reprint Perioperative blood conservation--the experts, the elephants, the clinicians, and the gauntlet
    Keyvan Karkouti
    Can J Anaesth 54:861-7. 2007