Gary J Kargacin

Summary

Affiliation: University of Calgary
Country: Canada

Publications

  1. ncbi Iodide and bromide inhibit Ca(2+) uptake by cardiac sarcoplasmic reticulum
    G J Kargacin
    Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    Am J Physiol Heart Circ Physiol 280:H1624-34. 2001
  2. ncbi Responses of Ca2+-binding proteins to localized, transient changes in intracellular [Ca2+]
    Gary J Kargacin
    Department of Physiology and Biophysics, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1
    J Theor Biol 221:245-58. 2003
  3. ncbi Inhibition of SERCA2 Ca(2+)-ATPases by Cs(+)
    Gary J Kargacin
    Department of Physiology and Biophysics, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada
    Pflugers Arch 449:356-63. 2005
  4. ncbi Localization of telokin at the intercalated discs of cardiac myocytes
    Gary J Kargacin
    Department of Physiology and Biophysics, University of Calgary, Calgary, Alta, Canada T2N 4N1
    Arch Biochem Biophys 456:151-60. 2006
  5. ncbi Effects of monovalent cations on Ca2+ uptake by skeletal and cardiac muscle sarcoplasmic reticulum
    Sanja Beca
    Department of Physiology and Biophysics, University of Calgary, Alta, Canada
    Arch Biochem Biophys 490:110-7. 2009
  6. ncbi Inhibition of a cardiac sarcoplasmic reticulum chloride channel by tamoxifen
    Sanja Beca
    Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, T2N 4N1, Canada
    Pflugers Arch 457:121-35. 2008
  7. ncbi Effects of phloretin and phloridzin on Ca2+ handling, the action potential, and ion currents in rat ventricular myocytes
    Marnie L Olson
    Department of Physiology and Biophysics, University of Calgary, 3330 Hospital Dr NW, Calgary, Alberta T2N 4N1, Canada E mail
    J Pharmacol Exp Ther 321:921-9. 2007
  8. ncbi Ca2+ regulation in the near-membrane microenvironment in smooth muscle cells
    Hojjat Bazzazi
    Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada
    Biophys J 85:1754-65. 2003
  9. ncbi Epigallocatechin-3-gallate has dual, independent effects on the cardiac sarcoplasmic reticulum/endoplasmic reticulum Ca2+ ATPase
    M E Kargacin
    Department of Physiology and Pharmacology, University of Calgary, 3330 Hospital Drive NW, Calgary, AB, T2N 4N1, Canada
    J Muscle Res Cell Motil 32:89-98. 2011
  10. ncbi Effects of phytoestrogens on sarcoplasmic/endoplasmic reticulum calcium ATPase 2a and Ca2+ uptake into cardiac sarcoplasmic reticulum
    Marnie L Olson
    Department of Physiology and Biophysics, University of Calgary, Canada
    J Pharmacol Exp Ther 316:628-35. 2006

Collaborators

Detail Information

Publications15

  1. ncbi Iodide and bromide inhibit Ca(2+) uptake by cardiac sarcoplasmic reticulum
    G J Kargacin
    Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    Am J Physiol Heart Circ Physiol 280:H1624-34. 2001
    ..Our results support the hypothesis that an anionic current that occurs during SR Ca(2+) uptake is reduced by the substitution of Br(-) or I(-) for Cl(-)...
  2. ncbi Responses of Ca2+-binding proteins to localized, transient changes in intracellular [Ca2+]
    Gary J Kargacin
    Department of Physiology and Biophysics, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1
    J Theor Biol 221:245-58. 2003
    ....
  3. ncbi Inhibition of SERCA2 Ca(2+)-ATPases by Cs(+)
    Gary J Kargacin
    Department of Physiology and Biophysics, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada
    Pflugers Arch 449:356-63. 2005
    ..Consideration of these results and the recent molecular modeling work of others suggests that monovalent cations could interact with the Ca(2+) binding region of SERCA...
  4. ncbi Localization of telokin at the intercalated discs of cardiac myocytes
    Gary J Kargacin
    Department of Physiology and Biophysics, University of Calgary, Calgary, Alta, Canada T2N 4N1
    Arch Biochem Biophys 456:151-60. 2006
    ....
  5. ncbi Effects of monovalent cations on Ca2+ uptake by skeletal and cardiac muscle sarcoplasmic reticulum
    Sanja Beca
    Department of Physiology and Biophysics, University of Calgary, Alta, Canada
    Arch Biochem Biophys 490:110-7. 2009
    ....
  6. ncbi Inhibition of a cardiac sarcoplasmic reticulum chloride channel by tamoxifen
    Sanja Beca
    Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, T2N 4N1, Canada
    Pflugers Arch 457:121-35. 2008
    ....
  7. ncbi Effects of phloretin and phloridzin on Ca2+ handling, the action potential, and ion currents in rat ventricular myocytes
    Marnie L Olson
    Department of Physiology and Biophysics, University of Calgary, 3330 Hospital Dr NW, Calgary, Alberta T2N 4N1, Canada E mail
    J Pharmacol Exp Ther 321:921-9. 2007
    ....
  8. ncbi Ca2+ regulation in the near-membrane microenvironment in smooth muscle cells
    Hojjat Bazzazi
    Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada
    Biophys J 85:1754-65. 2003
    ..Immunofluorescence imaging, however, did not reveal obvious differences in the density of SR Ca(2+) pumps or phospholamban between the peripheral and central SR in smooth muscle cells...
  9. ncbi Epigallocatechin-3-gallate has dual, independent effects on the cardiac sarcoplasmic reticulum/endoplasmic reticulum Ca2+ ATPase
    M E Kargacin
    Department of Physiology and Pharmacology, University of Calgary, 3330 Hospital Drive NW, Calgary, AB, T2N 4N1, Canada
    J Muscle Res Cell Motil 32:89-98. 2011
    ....
  10. ncbi Effects of phytoestrogens on sarcoplasmic/endoplasmic reticulum calcium ATPase 2a and Ca2+ uptake into cardiac sarcoplasmic reticulum
    Marnie L Olson
    Department of Physiology and Biophysics, University of Calgary, Canada
    J Pharmacol Exp Ther 316:628-35. 2006
    ..Neither compound induced a detectable change in the permeability of the SR membrane to Ca(2+). These results indicate that phloretin and phloridzin inhibit cardiac SR Ca(2+) uptake by directly inhibiting SERCA2a...
  11. ncbi High sensitivity, quantitative measurements of polyphosphate using a new DAPI-based approach
    Roozbeh Aschar-Sobbi
    Department of Physiology and Biophysics, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, T2N 4N1, Canada
    J Fluoresc 18:859-66. 2008
    ..In addition, we demonstrate the use of this protocol to measure the activity of poly-P hydrolyzing enzyme, polyphosphatase and demonstrate a similar signal from the mitochondrial region of cultured neurons...
  12. ncbi Postnatal changes in caldesmon expression and localization in cardiac myocytes
    Gail A McMartin
    Department of Physiology and Biophysics, University of Calgary, Alberta, Canada
    J Anat 203:369-77. 2003
    ....
  13. ncbi Inhibition of cAMP-dependent protein kinase under conditions occurring in the cardiac dyad during a Ca2+ transient
    Peter P Jones
    Institute of Membrane and Systems Biology, University of Leeds, Leeds LS2 9JT, United Kingdom
    Biophys J 91:433-43. 2006
    ....
  14. ncbi Inward rectifier K(+) currents and Kir2.1 expression in renal afferent and efferent arterioles
    Lisa Chilton
    Department of Pharmacology and Therapeutics, University of Calgary Faculty of Medicine, 3330 Hospital Drive N W, Calgary, Alberta T2N 4N1, Canada
    J Am Soc Nephrol 19:69-76. 2008
    ..The expression of Kir in the efferent arteriole, a resistance vessel whose tone is not affected by membrane potential, is intriguing and may suggest a novel function of this channel in the renal microcirculation...
  15. ncbi Tamoxifen inhibits Na+ and K+ currents in rat ventricular myocytes
    Jianying He
    Department of Physiology, Queen's University, Kingston, Ontario K7L 3N6, Canada
    Am J Physiol Heart Circ Physiol 285:H661-8. 2003
    ..The results of this study indicate that inhibition of Ito, Isus, and IK1 by tamoxifen may underlie AP prolongation in cardiac myocytes and thereby contribute to prolonged QT interval observed in patients...