Research Topics
| Moira K KapralSummaryAffiliation: University of Toronto Country: Canada Publications
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Detail Information
Publications
Neighborhood income and stroke care and outcomesMoira K Kapral
Department of Medicine, University of Toronto, Toronto, Canada
Neurology 79:1200-7. 2012..To evaluate factors that may contribute to the increased stroke case fatality rates observed in individuals from low-income areas...- Study protocol of the YOU CALL--WE CALL TRIAL: impact of a multimodal support intervention after a "mild" strokeAnnie Rochette
Montreal University, Montreal, Quebec, Canada
BMC Neurol 10:3. 2010.... 
Sex differences in stroke care and outcomes: results from the Registry of the Canadian Stroke NetworkMoira K Kapral
Department of Medicine, University of Toronto, Ontario, Canada
Stroke 36:809-14. 2005..Stroke is an important cause of death and disability in women as well as men. However, little is known about sex differences in stroke care and outcomes...- Gender differences in stroke care decision-makingMoira K Kapral
Institute for Clinical Evaluative Sciences, University Health Network, University of Toronto, Ontario, Canada
Med Care 44:70-80. 2006..Women are less likely than men to receive some stroke care interventions. It is not known whether gender differences in patient preferences explain some of the observed variations in stroke care delivery... - Effect of socioeconomic status on treatment and mortality after strokeMoira K Kapral
Institute for Clinical Evaluative Sciences, University Health Network University of Toronto, Ontario, Canada
Stroke 33:268-73. 2002..Socioeconomic status is associated with increased mortality from ischemic heart disease. We undertook a study to determine whether a similar association exists between socioeconomic status and stroke mortality... - Stroke care delivery in institutions participating in the Registry of the Canadian Stroke NetworkMoira K Kapral
Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
Stroke 35:1756-62. 2004..Guidelines and performance indicators have been established for acute stroke care. However, little is known about the process of stroke care delivery in Canada... 
Gender differences in stroke care and outcomes in OntarioMoira K Kapral
Department of Medicine, University of Toronto, Toronto General Hospital, 200 Elizabeth St, Toronto, Ontario, Canada
Womens Health Issues 21:171-6. 2011....- Sex differences in carotid endarterectomy outcomes: results from the Ontario Carotid Endarterectomy RegistryMoira K Kapral
Institute for Clinical Evaluative Sciences, Division of General Internal Medicine and Clinical Epidemiology and Women s Health Program, University Health Network, Toronto, Ontario, Canada
Stroke 34:1120-5. 2003..We used data from a large population-based carotid surgery registry to determine whether sex differences exist in the risk of perioperative complications from carotid endarterectomy... - Stroke management in womenMoira K Kapral
University of Toronto, Toronto General Hospital, 200 Elizabeth St 14EN 215, Toronto, Ontario, M5G 2C4, Canada
Womens Health (Lond Engl) 2:597-603. 2006..The focus of this article is an overview of some of the key issues related to the management of stroke in women... - Potentially preventable strokes in high-risk patients with atrial fibrillation who are not adequately anticoagulatedDavid J Gladstone
FRCPC, Director, Regional Stroke Prevention Clinic, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Room A442, Toronto, Ontario, Canada
Stroke 40:235-40. 2009..This study examined the magnitude of this problem in a large contemporary, prospective stroke registry... - Do all age groups benefit from organized inpatient stroke care?Gustavo Saposnik
Stroke Research Unit, Division of Neurology, Department of Medicine, Stroke Outcome Research Canada, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
Stroke 40:3321-7. 2009..We sought to determine whether the reduction in mortality or institutionalization seen with organized stroke care was similar across all age groups... - Age disparities in stroke quality of care and delivery of health servicesGustavo Saposnik
Stroke Research Unit, Division of Neurology, Department of Medicine, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
Stroke 40:3328-35. 2009..Limited information is available on the effect of age on stroke management and care delivery. Our aim was to determine whether access to stroke care, delivery of health services, and clinical outcomes after stroke are affected by age... - Higher incidence of in-hospital complications in patients with clipped versus coiled ruptured intracranial aneurysmsMervyn D I Vergouwen
Department of Medicine, Division of Neurology, University Health Network, University of Toronto, Toronto, Canada
Stroke 42:3093-8. 2011..It remains unknown if patients with clipped aneurysms also have a higher incidence of other in-hospital complications... - International experience in stroke registries: lessons learned in establishing the Registry of the Canadian Stroke NetworkFrank L Silver
Division of Neurology, University of Toronto, Toronto, Ontario, Canada
Am J Prev Med 31:S235-7. 2006..The need for stroke registries to collect accurate data that are representative of all patients with acute stroke in a given community is emphasized, and how the current methodology strives to reach this goal is outlined... - Escalating levels of access to in-hospital care and stroke mortalityGustavo Saposnik
Stroke Research Unit, Division of Neurology, Department of Medicine, St Michael s Hospital, University of Toronto, Toronto, M5C 1R6, Canada
Stroke 39:2522-30. 2008..However, limited information is available comparing different levels of organized care. Our aim was to determine whether escalating levels of organized care can improve stroke outcomes... - Stroke unit care: does ischemic stroke subtype matter?Gustavo Saposnik
Stroke Outcomes Research Unit, Stroke Research Unit, Department of Medicine, Division of Neurology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
Int J Stroke 6:244-50. 2011..Stroke unit care improves outcomes following ischemic stroke. However, it is not known whether all ischemic stroke subtypes benefit equally from stroke unit admission... - IScore: a risk score to predict death early after hospitalization for an acute ischemic strokeGustavo Saposnik
Stroke Outcomes Research Centre, Stroke Outcome Research Canada Working Group, Department of Medicine, St Michael s Hospital, University of Toronto, 55 Queen St E, Toronto, Ontario, Canada
Circulation 123:739-49. 2011..Our aim was to identify predictors of mortality and to develop and validate a risk score model using information available at hospital presentation... - Socioeconomic status, hospital volume, and stroke fatality in CanadaGustavo Saposnik
Department of Medicine, Division of Neurology, Stroke Research Unit, South East Toronto Regional Stroke Center, St Michael sHospital, University of Toronto, Toronto, Canada
Stroke 39:3360-6. 2008..We sought to determine whether residence in a low-income neighborhood was associated with admission to low-volume facilities and whether this contributed to differences in fatality after stroke... - The iScore predicts effectiveness of thrombolytic therapy for acute ischemic strokeGustavo Saposnik
Department of Medicine, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
Stroke 43:1315-22. 2012..The purpose of this study was to determine the ability of the iScore to predict clinical response and risk of hemorrhagic transformation after tPA... - The iScore predicts poor functional outcomes early after hospitalization for an acute ischemic strokeGustavo Saposnik
Stroke Outcomes Research Unit, Stroke Outcome Research Canada Working Group, Department of Medicine, St Michael s Hospital, University of Toronto, 55 Queen Street E, Toronto, Ontario, M5C 1R6, Canada
Stroke 42:3421-8. 2011..The iScore is a prediction tool originally developed to estimate the risk of death after hospitalization for an acute ischemic stroke. Our objective was to determine whether the iScore could also predict poor functional outcomes... - Association between weekend hospital presentation and stroke fatalityJiming Fang
Toronto General Hospital, 200 Elizabeth Street, Toronto, Ontario, Canada
Neurology 75:1589-96. 2010..Previous studies have found higher stroke case fatality in patients admitted to the hospital on weekends compared to weekdays, but the reasons for this association are not known... - Variables associated with 7-day, 30-day, and 1-year fatality after ischemic strokeGustavo Saposnik
Stroke Research Unit, Division of Neurology, Department of Medicine, Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, Canada
Stroke 39:2318-24. 2008..However, limited information is available concerning variables associated with stroke case fatality at these different points in time. We sought to identify and compare variables associated with 7-day, 30-day, and 1-year stroke fatality... - The Registry of Canadian Stroke Network : an evolving methodologyJiming Fang
Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
Acta Neurol Taiwan 20:77-84. 2011..The changes in the data collection methodology developed by the RCSN can be applied to other provinces and countries... - The impact of severe acute respiratory syndrome on medical house staff: a qualitative studyGloria Rambaldini
Division of General Internal Medicine, University Health Network, Toronto, Ontario, Canada
J Gen Intern Med 20:381-5. 2005..It is hoped that training programs for health care professionals will be able to implement these tenets of crisis management as they develop strategies for dealing with future health threats... - Urgency of carotid endarterectomy for secondary stroke prevention: results from the Registry of the Canadian Stroke NetworkDavid J Gladstone
Stroke Prevention Clinic, Division of Neurology and Regional Stroke Centre, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Room A442, Toronto, Ontario, Canada M4N 3M5
Stroke 40:2776-82. 2009..This study examined time to endarterectomy at designated stroke centers as a measure of evidence-based best practices for stroke prevention... - Variation in recruitment across sites in a consent-based clinical data registry: lessons from the Canadian Stroke NetworkDonald J Willison
Centre for Evaluation of Medicines, St, Joseph s Healthcare, Department of Clinical Epidemiology and Biostatistics, McMaster University Hamilton, Ontario, Canada
BMC Med Ethics 7:E6. 2006.... - Short-term outcomes after symptomatic internal carotid artery occlusionMatthew J Burke
Toronto Western Hospital, 399 Bathurst Street, West Wing 5 448, Toronto, Ontario, M5T 2S8, Canada
Stroke 42:2419-24. 2011..Previous studies concerning internal carotid artery (ICA) occlusion have focused on long-term prognosis. The purpose of the present study was to evaluate short-term outcomes of patients with symptomatic ICA occlusion... - Relation between age and cardiovascular disease in men and women with diabetes compared with non-diabetic people: a population-based retrospective cohort studyGillian L Booth
Department of Medicine, University of Toronto, Toronto, Ontario, Canada
Lancet 368:29-36. 2006.... - Subtherapeutic warfarin is not associated with increased hemorrhage rates in ischemic strokes treated with tissue plasminogen activatorMervyn D I Vergouwen
University of Toronto, Toronto Western Hospital, Department of Medicine, Division of Neurology, 399 Bathurst Street, 5th Floor, West Wing, Room 443, Toronto, Ontario M5T 2S8, Canada
Stroke 42:1041-5. 2011..7. However, evidence to date has been derived from a small single-center cohort of patients... - Organized outpatient care: stroke prevention clinic referrals are associated with reduced mortality after transient ischemic attack and ischemic strokeFiona Webster
Department of Surgery, University of Toronto, Toronto, Ontario, M5G 1V7, Canada
Stroke 42:3176-82. 2011..We compared 1-year mortality and stroke readmission in patients with transient ischemic attack or ischemic stroke referred versus not referred to an SPC... - Impracticability of informed consent in the Registry of the Canadian Stroke NetworkJack V Tu
Institute for Clinical Evaluative Sciences, Toronto, ON, Canada
N Engl J Med 350:1414-21. 2004..However, the effect of such a requirement on the use of clinical registries and the extent to which registry data can be generalized remain uncertain... - Socioeconomic status and care after stroke: results from the Registry of the Canadian Stroke NetworkKun Huang
Department of Medicine, University of Toronto, Toronto, Ontario, Canada
Stroke 44:477-82. 2013..We undertook a study to determine whether posthospitalization care and medication adherence vary with neighborhood income... - Association of statins and statin discontinuation with poor outcome and survival after intracerebral hemorrhageDar Dowlatshahi
Division of Neurology, University of Ottawa, Ottawa, Ontario, Canada
Stroke 43:1518-23. 2012..We studied the relationship between preintracerebral hemorrhage statin use and in-hospital statin discontinuation on stroke severity and 30-day mortality... - Is pre-existing dementia an independent predictor of outcome after stroke? A propensity score-matched analysisGustavo Saposnik
Division of Neurology, Departments of Medicine and Health Policy, Management and Evaluation, Institute for Clinical Evaluative Sciences, St Michael s Hospital, University of Toronto, 55 Queen St East, Suite 931, Toronto, ON, M5C 1R6, Canada
J Neurol 259:2366-75. 2012..Pre-existing dementia may not necessarily preclude access to thrombolytic therapy and specialized stroke care... - Variability in physician care practices for glucose treatment in stroke patientsLeanne K Casaubon
University Health Network, Toronto, Canada
Can J Neurol Sci 35:573-82. 2008..Practice guidelines recommend glucose monitoring following stroke but provide few management recommendations. We examined physician care practices for glucose management in stroke patients... - Management and outcomes of transient ischemic attacks in OntarioDavid J Gladstone
Division of Neurology, Department of Medicine, and the Regional Stroke Centre, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Toronto, Ont
CMAJ 170:1099-104. 2004..We studied prospectively a cohort of consecutive patients presenting with TIA to the emergency department of 4 regional stroke centres in Ontario... - Recent trends in cardiovascular complications among men and women with and without diabetesGillian L Booth
Department of Medicine, University of Toronto, Ontario, Canada
Diabetes Care 29:32-7. 2006..To compare recent trends in cardiovascular disease (CVD) outcomes among men and women with diabetes with those in the nondiabetic population... - Reinitiation of anticoagulation after warfarin-associated intracranial hemorrhage and mortality risk: the Best Practice for Reinitiating Anticoagulation Therapy After Intracranial Bleeding (BRAIN) studyDerek Yung
Division of Cardiology, University of Toronto, Toronto, Ontario, Canada
Can J Cardiol 28:33-9. 2012..While warfarin-related intracranial hemorrhage (ICH) occurs in 0.25%-1.1% patients per year, little is known about the practice and outcomes of anticoagulant reinitiation... - Predictors of antiviral therapy in a post-transfusion cohort of hepatitis C patientsMaciej Witkos
Department of Health Policy, Management and Evaluation, University of Toronto, Toronto General Hospital, Ontario, Canada
Can J Gastroenterol 20:107-11. 2006..Further work is required to understand barriers to treatment related to geography, organization of medical care, age, medical provider and patient preferences... - Bone density and structure in healthy postmenopausal women treated with exemestane for the primary prevention of breast cancer: a nested substudy of the MAP.3 randomised controlled trialAngela M Cheung
University Health Network, University of Toronto, Toronto, ON, Canada
Lancet Oncol 13:275-84. 2012..Exemestane can prevent breast cancer in postmenopausal women. Because of potential widespread use, we examined the safety of exemestane on bone health... - Progress in clinical neurosciences: pharmacotherapies for the secondary prevention of strokeDaniel G Hackam
From the Division of Clinical Pharmacology, University of Toronto, Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
Can J Neurol Sci 31:295-303. 2004..We review the literature to determine the clinical significance of these therapies, and provide recommendations regarding their use in the prevention of recurrent stroke... - The Canadian Stroke Quality of Care Study: establishing indicators for optimal acute stroke careM Patrice Lindsay
Institute for Clinical Evaluative Sciences and the Department of Medicine, University of Toronto, Toronto, Ont
CMAJ 172:363-5. 2005 - Effect of depression on five-year mortality after an acute coronary syndromeSherry L Grace
York University, Toronto, Ontario, Canada
Am J Cardiol 96:1179-85. 2005.... - The safety of proton pump inhibitors and clopidogrel in patients after strokeDavid N Juurlink
Sunnybrook Research Institute, Toronto, Ontario, Canada
Stroke 42:128-32. 2011..evidence suggests that some proton pump inhibitors can attenuate the antiplatelet effect of clopidogrel. The significance of this potential drug interaction in patients with cerebrovascular disease is unknown... - Severe acute respiratory syndrome and its impact on professionalism: qualitative study of physicians' behaviour during an emerging healthcare crisisSharon E Straus
Division of General Internal Medicine, University Health Network, 200 Elizabeth Street, Toronto, ON, Canada M5G 2C4
BMJ 329:83. 2004..To explore issues of medical professionalism in the context of severe acute respiratory syndrome (SARS), a new emerging health threat... - Gender differences in stroke examined in a 10-year cohort of patients admitted to a Canadian teaching hospitalJohn M Reid
Institute of Neurological Sciences, 1345 Govan Road, Glasgow, UK G51 4TF
Stroke 39:1090-5. 2008..We tested whether gender differences in the investigation, treatment, and outcome of stroke are due to confounding factors... - Outcome after stroke upon awakeningJanel O Nadeau
Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada
Can J Neurol Sci 32:232-6. 2005..Functional outcomes are slightly worse among patients with stroke-on-awakening, an effect which was driven by poor outcomes among patients with subarachnoid hemorrhage... - TPA use for stroke in the Registry of the Canadian Stroke NetworkJanel O Nadeau
Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
Can J Neurol Sci 32:433-9. 2005..2, approximately equivalent to a modified Rankin scale score of 2. CONCLUSIONS: At selected hospitals in Canada, thrombolysis use is higher than previously reported rates. Thrombolysis continues to be safe and effective in Canada... - Intracerebral hemorrhage: outcomes and eligibility for factor VIIa treatment in a National Stroke RegistryJanel O Nadeau
Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Calgary, Canada
Cerebrovasc Dis 22:271-5. 2006..In Canada, about one fifth of ICH patients might potentially benefit from rFVIIa if it is approved, with the major exclusion factor being time... - Poststroke care: chronicles of a neglected battleGustavo Saposnik
Stroke 38:1727-9. 2007 - Detecting paroxysmal atrial fibrillation after ischemic stroke and transient ischemic attack: if you don't look, you won't findDavid J Gladstone
Stroke 39:e78-9; discussion e80. 2008