Lisa E Kalynchuk

Summary

Affiliation: University of Saskatchewan
Country: Canada

Publications

  1. ncbi request reprint Serotonin receptor binding and mRNA expression in the hippocampus of fearful amygdala-kindled rats
    Lisa E Kalynchuk
    Department of Psychology, University of Saskatchewan, 9 Campus Drive, Saskatoon, Sask, Canada S7N 5A5
    Neurosci Lett 396:38-43. 2006
  2. doi request reprint Reelin as a putative vulnerability factor for depression: examining the depressogenic effects of repeated corticosterone in heterozygous reeler mice
    April L Lussier
    Neural Systems and Plasticity Research Group, Department of Psychology, University of Saskatchewan, Saskatoon, Saskatchewan S7V1C2, Canada
    Neuropharmacology 60:1064-74. 2011
  3. doi request reprint The progressive development of depression-like behavior in corticosterone-treated rats is paralleled by slowed granule cell maturation and decreased reelin expression in the adult dentate gyrus
    April L Lussier
    Department of Psychology, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5A5, Canada
    Neuropharmacology 71:174-83. 2013
  4. doi request reprint Altered synapsin I immunoreactivity and fear behavior in male and female rats subjected to long-term amygdala kindling
    Neil M Fournier
    Department of Psychology, University of Saskatchewan, 9 Campus Drive, Saskatoon, Saskatchewan, Canada
    Behav Brain Res 196:106-15. 2009
  5. doi request reprint Decreased levels of disrupted-in-schizophrenia 1 (DISC1) are associated with expansion of the dentate granule cell layer in normal and kindled rats
    Neil M Fournier
    Department of Psychology, University of Saskatchewan, Saskatoon, SK, Canada
    Neurosci Lett 455:134-9. 2009
  6. ncbi request reprint Behavioral and neurobiological consequences of prolonged glucocorticoid exposure in rats: relevance to depression
    Erin Y Sterner
    Department of Psychology, 9 Campus Drive, University of Saskatchewan, Saskatoon, SK, Canada S7N 5A5
    Prog Neuropsychopharmacol Biol Psychiatry 34:777-90. 2010
  7. doi request reprint Repeated exposure to corticosterone increases depression-like behavior in two different versions of the forced swim test without altering nonspecific locomotor activity or muscle strength
    Wendie Marks
    Department of Psychology, University of Saskatchewan, Saskatoon, SK, Canada S7N 5A5
    Physiol Behav 98:67-72. 2009
  8. doi request reprint Repeated exposure to corticosterone, but not restraint, decreases the number of reelin-positive cells in the adult rat hippocampus
    April L Lussier
    Department of Psychology, University of Saskatchewan, 9 Campus Drive, Saskatoon, Saskatchewan S7N 5A5, Canada
    Neurosci Lett 460:170-4. 2009
  9. ncbi request reprint Amygdala kindling decreases insulin-like growth factor-I receptor binding sites in the rat hippocampus
    Lisa E Kalynchuk
    Department of Psychology, Dalhousie University, Halifax, Nova Scotia B3H 4J1, Canada
    Brain Res 935:118-23. 2002
  10. ncbi request reprint Environmental enrichment facilitates amygdala kindling but reduces kindling-induced fear in male rats
    Nicole A Young
    Department of Psychology, Dalhousie University, 1355 Oxford Street, Halifax, NS B3H 4J1, Canada
    Behav Neurosci 118:1128-33. 2004

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Serotonin receptor binding and mRNA expression in the hippocampus of fearful amygdala-kindled rats
    Lisa E Kalynchuk
    Department of Psychology, University of Saskatchewan, 9 Campus Drive, Saskatoon, Sask, Canada S7N 5A5
    Neurosci Lett 396:38-43. 2006
    ..These results suggest that alterations in 5-HT1A receptors in the dentate gyrus may play a role in the expression of kindled fear...
  2. doi request reprint Reelin as a putative vulnerability factor for depression: examining the depressogenic effects of repeated corticosterone in heterozygous reeler mice
    April L Lussier
    Neural Systems and Plasticity Research Group, Department of Psychology, University of Saskatchewan, Saskatoon, Saskatchewan S7V1C2, Canada
    Neuropharmacology 60:1064-74. 2011
    ..This article is part of a Special Issue entitled 'Trends in neuropharmacology: in memory of Erminio Costa'...
  3. doi request reprint The progressive development of depression-like behavior in corticosterone-treated rats is paralleled by slowed granule cell maturation and decreased reelin expression in the adult dentate gyrus
    April L Lussier
    Department of Psychology, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5A5, Canada
    Neuropharmacology 71:174-83. 2013
    ..These results support our hypothesis that reelin plays a role in the pathogenesis of depression and suggest that reelin could be an important target for the development of novel therapeutics for the treatment of depression...
  4. doi request reprint Altered synapsin I immunoreactivity and fear behavior in male and female rats subjected to long-term amygdala kindling
    Neil M Fournier
    Department of Psychology, University of Saskatchewan, 9 Campus Drive, Saskatoon, Saskatchewan, Canada
    Behav Brain Res 196:106-15. 2009
    ..These results suggest that altered synaptic plasticity in specific brain regions might be involved in the exaggerated fearfulness produced by long-term amygdala kindling, especially in male rats...
  5. doi request reprint Decreased levels of disrupted-in-schizophrenia 1 (DISC1) are associated with expansion of the dentate granule cell layer in normal and kindled rats
    Neil M Fournier
    Department of Psychology, University of Saskatchewan, Saskatoon, SK, Canada
    Neurosci Lett 455:134-9. 2009
    ..These novel findings suggest that seizure activity affects DISC1 signaling in the dentate gyrus and that DISC1 expression may regulate the cytoarchitectural organization of the granule cell layer...
  6. ncbi request reprint Behavioral and neurobiological consequences of prolonged glucocorticoid exposure in rats: relevance to depression
    Erin Y Sterner
    Department of Psychology, 9 Campus Drive, University of Saskatchewan, Saskatoon, SK, Canada S7N 5A5
    Prog Neuropsychopharmacol Biol Psychiatry 34:777-90. 2010
    ..Further study with this model may provide important new data regarding the neurobiological bases of depression...
  7. doi request reprint Repeated exposure to corticosterone increases depression-like behavior in two different versions of the forced swim test without altering nonspecific locomotor activity or muscle strength
    Wendie Marks
    Department of Psychology, University of Saskatchewan, Saskatoon, SK, Canada S7N 5A5
    Physiol Behav 98:67-72. 2009
    ..These results show that repeated CORT injections increase depression-like behavior regardless of the specific parameters of forced swim testing, and that these effects are independent of changes in locomotor activity or muscle strength...
  8. doi request reprint Repeated exposure to corticosterone, but not restraint, decreases the number of reelin-positive cells in the adult rat hippocampus
    April L Lussier
    Department of Psychology, University of Saskatchewan, 9 Campus Drive, Saskatoon, Saskatchewan S7N 5A5, Canada
    Neurosci Lett 460:170-4. 2009
    ..These novel findings suggest that altered reelin signaling could play a role in the expression of depressive symptomatology after exposure to high levels of glucocorticoids...
  9. ncbi request reprint Amygdala kindling decreases insulin-like growth factor-I receptor binding sites in the rat hippocampus
    Lisa E Kalynchuk
    Department of Psychology, Dalhousie University, Halifax, Nova Scotia B3H 4J1, Canada
    Brain Res 935:118-23. 2002
    ..These results, in keeping with the established neurotrophic effects of IGF-I, suggest a potential role for this growth factor in mediating the structural alterations associated with kindling...
  10. ncbi request reprint Environmental enrichment facilitates amygdala kindling but reduces kindling-induced fear in male rats
    Nicole A Young
    Department of Psychology, Dalhousie University, 1355 Oxford Street, Halifax, NS B3H 4J1, Canada
    Behav Neurosci 118:1128-33. 2004
    ..These results suggest that environmental enrichment has differential effects on kindling acquisition and its behavioral consequences...
  11. ncbi request reprint Amygdala kindling increases fear responses and decreases glucocorticoid receptor mRNA expression in hippocampal regions
    Lisa E Kalynchuk
    Department of Psychology and Neuroscience Institute, Dalhousie University, 1355 Oxford Street, B3H 4J1, Halifax, Nova Scotia, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 27:1225-34. 2003
    ..These results suggest that alterations in GR mRNA expression in hippocampal regions may play a role in the development of kindling-induced fear...
  12. pmc Postnatal inflammation increases seizure susceptibility in adult rats
    Michael A Galic
    Epilepsy and Brain Circuits Program, Hotchkiss Brain Institute, Department of Neuroscience, University of Calgary, Calgary, Alberta, Canada
    J Neurosci 28:6904-13. 2008
    ..These novel results indicate that a single LPS injection during a critical postnatal period causes a long-lasting increase in seizure susceptibility that is strongly dependent on TNFalpha...
  13. ncbi request reprint Corticosterone increases depression-like behavior, with some effects on predator odor-induced defensive behavior, in male and female rats
    Lisa E Kalynchuk
    Department of Psychology, Dalhousie University, Halifax, Nova Scotia, Canada
    Behav Neurosci 118:1365-77. 2004
    ..These results suggest that repeated exposure to corticosterone increases depression-like behavior, with some effects on anxiety, and that male rats may be more affected than female rats by this manipulation...
  14. ncbi request reprint Sex and repeated restraint stress interact to affect cat odor-induced defensive behavior in adult rats
    Tara S Perrot-Sinal
    Department of Psychology and Neuroscience Institute, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4J1
    Brain Res 1027:161-72. 2004
    ..These findings indicate the utility of the predator odor paradigm in detecting subtle shifts in naturally occurring anxiety-like behaviors that may occur differentially in males and females...
  15. ncbi request reprint Effect of repeated corticosterone injections and restraint stress on anxiety and depression-like behavior in male rats
    Andrea Gregus
    Molecular Psychiatry Laboratory, Department of Psychology and Neuroscience Institute, Dalhousie University, Halifax, NS, Canada B3H 4J1
    Behav Brain Res 156:105-14. 2005
    ..These results suggest that repeated CORT injections warrant further investigation as an animal model to study the role of stress in depression...
  16. ncbi request reprint Kindling-induced emotional behavior in male and female rats
    Amanda J Wintink
    Department of Psychology, Dalhousie University, 1355 Oxford Street, Halifax, Nova Scotia B3H 4J1, Canada
    Behav Neurosci 117:632-40. 2003
    ..These results suggest that kindling-induced fear is generally similar in male and female rats and that kindling does not appear to induce depression-like behavior...
  17. ncbi request reprint Effect of different doses of corticosterone on depression-like behavior and HPA axis responses to a novel stressor
    Sarah A Johnson
    Centre for Addiction and Mental Health, Institute of Medical Science, University of Toronto, R 56, 250 College Street, Toronto, Ont, Canada M5T 1R8
    Behav Brain Res 168:280-8. 2006
    ..These results support the hypothesis that high levels of cortisol contribute to the etiology of depressive symptomatology in humans...