Mads Kaern

Summary

Affiliation: University of Ottawa
Country: Canada

Publications

  1. pmc Estimating the stochastic bifurcation structure of cellular networks
    Carl Song
    Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
    PLoS Comput Biol 6:e1000699. 2010
  2. pmc Quantitative epistasis analysis and pathway inference from genetic interaction data
    Hilary Phenix
    Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada
    PLoS Comput Biol 7:e1002048. 2011
  3. pmc Identification of response-modulated genetic interactions by sensitivity-based epistatic analysis
    Cory Batenchuk
    Ottawa Institute of Systems Biology, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, K1H 8M5, Canada
    BMC Genomics 11:493. 2010
  4. ncbi request reprint Stochasticity in gene expression: from theories to phenotypes
    Mads Kaern
    Department of Cellular and Molecular Medicine and Ottawa Institute of Systems Biology, University of Ottawa, 451 Smyth Road, Ottawa, Ontario K1H8M5, Canada
    Nat Rev Genet 6:451-64. 2005
  5. doi request reprint A chance at survival: gene expression noise and phenotypic diversification strategies
    Dawn Fraser
    Ottawa Institute of Systems Biology, Ottawa, Canada
    Mol Microbiol 71:1333-40. 2009
  6. pmc A non-death role of the yeast metacaspase: Yca1p alters cell cycle dynamics
    Robin E C Lee
    Regenerative Medicine Program, Ottawa Health Research Institute, Sprott Centre for Stem Cell Research, Ottawa, Canada
    PLoS ONE 3:e2956. 2008
  7. ncbi request reprint Gene expression noise facilitates adaptation and drug resistance independently of mutation
    Daniel A Charlebois
    Department of Physics, University of Ottawa, Ontario, Canada
    Phys Rev Lett 107:218101. 2011
  8. pmc Physics takes another stab at biological design principles
    Daniil Zhuravel
    Mol Syst Biol 1:2005.0029. 2005
  9. ncbi request reprint The engineering of gene regulatory networks
    Mads Kaern
    Center for BioDynamics, Department of Biomedical Engineering, and Bioinformatics Program, Boston University, Boston, Massachusetts 02215, USA
    Annu Rev Biomed Eng 5:179-206. 2003
  10. ncbi request reprint Noise in eukaryotic gene expression
    William J Blake
    Center for BioDynamics, Center for Advanced Biotechnology, Bioinformatics Program, and Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, Massachusetts 02215, USA
    Nature 422:633-7. 2003

Collaborators

Detail Information

Publications14

  1. pmc Estimating the stochastic bifurcation structure of cellular networks
    Carl Song
    Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
    PLoS Comput Biol 6:e1000699. 2010
    ....
  2. pmc Quantitative epistasis analysis and pathway inference from genetic interaction data
    Hilary Phenix
    Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada
    PLoS Comput Biol 7:e1002048. 2011
    ..Strikingly, when the analyses of the two traits are combined, the method correctly infers ~80% of the known relationships without any false positives...
  3. pmc Identification of response-modulated genetic interactions by sensitivity-based epistatic analysis
    Cory Batenchuk
    Ottawa Institute of Systems Biology, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, K1H 8M5, Canada
    BMC Genomics 11:493. 2010
    ....
  4. ncbi request reprint Stochasticity in gene expression: from theories to phenotypes
    Mads Kaern
    Department of Cellular and Molecular Medicine and Ottawa Institute of Systems Biology, University of Ottawa, 451 Smyth Road, Ottawa, Ontario K1H8M5, Canada
    Nat Rev Genet 6:451-64. 2005
    ..It can provide the flexibility needed by cells to adapt to fluctuating environments or respond to sudden stresses, and a mechanism by which population heterogeneity can be established during cellular differentiation and development...
  5. doi request reprint A chance at survival: gene expression noise and phenotypic diversification strategies
    Dawn Fraser
    Ottawa Institute of Systems Biology, Ottawa, Canada
    Mol Microbiol 71:1333-40. 2009
    ..Here, we discuss different scenarios where gene expression noise might bestow a selective advantage under stress, highlighting a potentially fundamental role of stochastic mechanisms in the evolution of microbial survival strategies...
  6. pmc A non-death role of the yeast metacaspase: Yca1p alters cell cycle dynamics
    Robin E C Lee
    Regenerative Medicine Program, Ottawa Health Research Institute, Sprott Centre for Stem Cell Research, Ottawa, Canada
    PLoS ONE 3:e2956. 2008
    ..Our results demonstrate multiple non-death roles for yca1 in the cell cycle...
  7. ncbi request reprint Gene expression noise facilitates adaptation and drug resistance independently of mutation
    Daniel A Charlebois
    Department of Physics, University of Ottawa, Ontario, Canada
    Phys Rev Lett 107:218101. 2011
    ..We examine how this effect contributes to the development of drug-resistant cancer cells, and demonstrate that permanent immunity can arise independently of mutations...
  8. pmc Physics takes another stab at biological design principles
    Daniil Zhuravel
    Mol Syst Biol 1:2005.0029. 2005
  9. ncbi request reprint The engineering of gene regulatory networks
    Mads Kaern
    Center for BioDynamics, Department of Biomedical Engineering, and Bioinformatics Program, Boston University, Boston, Massachusetts 02215, USA
    Annu Rev Biomed Eng 5:179-206. 2003
    ....
  10. ncbi request reprint Noise in eukaryotic gene expression
    William J Blake
    Center for BioDynamics, Center for Advanced Biotechnology, Bioinformatics Program, and Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, Massachusetts 02215, USA
    Nature 422:633-7. 2003
    ..This result has implications for the role of noise in phenotypic variation and cellular differentiation...
  11. ncbi request reprint Estimations of intrinsic and extrinsic noise in models of nonlinear genetic networks
    Matthew Scott
    Center for Theoretical Biological Physics, Department of Physics, University of California, San Diego, La Jolla, California, 92093 0374, USA
    Chaos 16:026107. 2006
    ..The methods allow for rapid estimations of intrinsic and extrinsic noise and should prove useful in the analysis of natural genetic networks and when constructing synthetic gene regulatory systems...
  12. ncbi request reprint Predictable trends in protein noise
    Kristin Baetz
    Nat Genet 38:610-1. 2006
  13. pmc Programmable cells: interfacing natural and engineered gene networks
    Hideki Kobayashi
    Department of Biomedical Engineering, Center for BioDynamics, and Center for Advanced Biotechnology, Boston University, 44 Cummington Street, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 101:8414-9. 2004
    ..Our work represents a step toward the development of "plug-and-play" genetic circuitry that can be used to create cells with programmable behaviors...