B H Juurlink

Summary

Affiliation: University of Saskatchewan
Country: Canada

Publications

  1. ncbi request reprint Can dietary intake of phase 2 protein inducers affect the rising epidemic of diseases such as type 2 diabetes?
    Bernhard H J Juurlink
    Department of Anatomy Cell Biology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    MedGenMed 5:25. 2003
  2. ncbi request reprint Peroxide-scavenging deficit underlies oligodendrocyte susceptibility to oxidative stress
    B H Juurlink
    Department of Anatomy and Cell Biology, College of Medicine, University of Saskatchewan, Saskatoon, Canada
    Glia 22:371-8. 1998
  3. ncbi request reprint Therapeutic potential of dietary phase 2 enzyme inducers in ameliorating diseases that have an underlying inflammatory component
    B H Juurlink
    Department of Anatomy and Cell Biology, The Cameco Multiple Sclerosis and Neuroscience Research Centre, College of Medicine, University of Saskatchewan, Saskatoon, Canada
    Can J Physiol Pharmacol 79:266-82. 2001
  4. ncbi request reprint The multiple sclerosis lesion: initiated by a localized hypoperfusion in a central nervous system where mechanisms allowing leukocyte infiltration are readily upregulated?
    B H Juurlink
    Department of Anatomy and Cell Biology, Cameco Multiple Sclerosis and Neuroscience Research Centre, College of Medicine, University of Saskatchewan, Saskatoon, Canada
    Med Hypotheses 51:299-303. 1998
  5. ncbi request reprint Inhibition of phosphoenolpyruvate carboxykinase (PEPCK) gene expression by troglitazone: a peroxisome proliferator-activated receptor-gamma (PPARgamma)-independent, antioxidant-related mechanism
    G F Davies
    Department of Biochemistry, University of Saskatchewan, 107 Wiggins Road, Saskatchewan S7N 5E5, Saskatoon, Canada
    Biochem Pharmacol 62:1071-9. 2001
  6. ncbi request reprint Promoting glutathione synthesis after spinal cord trauma decreases secondary damage and promotes retention of function
    H Kamencic
    Department of Anatomy, University of Saskatchewan, Saskatoon, SK, Canada
    FASEB J 15:243-250. 2001
  7. ncbi request reprint The impaired glutathione system and its up-regulation by sulforaphane in vascular smooth muscle cells from spontaneously hypertensive rats
    L Wu
    Department of Anatomy and Cell Biology, College of Medicine, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK, Canada S7N 5E5
    J Hypertens 19:1819-25. 2001
  8. ncbi request reprint Sulfur amino acid deficiency depresses brain glutathione concentration
    P G Paterson
    College of Pharmacy and Nutrition, Cameco Multiple Sclerosis and Neuroscience Research Center, University of Saskatchewan, Saskatoon, Canada
    Nutr Neurosci 4:213-22. 2001
  9. doi request reprint Memory and survival after microbeam radiation therapy
    Elisabeth Schultke
    University of Saskatchewan, Saskatoon, 107 Wiggins Road, Saskatoon, SK S7N 5E5, Canada
    Eur J Radiol 68:S142-6. 2008
  10. ncbi request reprint Troglitazone selectively inhibits glyoxalase I gene expression
    L Wu
    Department of Anatomy and Cell Biology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada
    Diabetologia 44:2004-12. 2001

Collaborators

  • P G Paterson
  • W J Roesler
  • L Hertz
  • Susan Joyce Whiting
  • Jane Alcorn
  • E Schultke
  • Mohammad Hossein Noyan-Ashraf
  • L Wu
  • Jennifer L Adolphe
  • G F Davies
  • Jamie D Golding
  • P Joan Bobyn
  • H Kamencic
  • Lilian U Thorpe
  • Gerald F Davies
  • Deborah Saucier
  • Zahra Sadeghinejad
  • Troy A A Harkness
  • Andrew R Ross
  • Benjamin W C Rosser
  • Rui Wang
  • Sarah T Rigley MacDonald
  • Lingyun Wu
  • Federica Brandizzi
  • James A Thornhill
  • Cindy M Wall
  • Jodi L Franklin
  • E Eftekharpour
  • A W Lyon
  • R W Griebel
  • R L Khandelwal

Detail Information

Publications16

  1. ncbi request reprint Can dietary intake of phase 2 protein inducers affect the rising epidemic of diseases such as type 2 diabetes?
    Bernhard H J Juurlink
    Department of Anatomy Cell Biology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    MedGenMed 5:25. 2003
    ..This hypothesis can be readily tested by examining basal and induced phase 2 protein gene expression in umbilical cord fibroblasts, obtained from infants of different genetic backgrounds, grown in cell culture...
  2. ncbi request reprint Peroxide-scavenging deficit underlies oligodendrocyte susceptibility to oxidative stress
    B H Juurlink
    Department of Anatomy and Cell Biology, College of Medicine, University of Saskatchewan, Saskatoon, Canada
    Glia 22:371-8. 1998
    ..Oligodendroglia have high iron stores, and thus these findings emphasize how vulnerable the oligodendroglial lineage is to perturbations that result in oxidative stress...
  3. ncbi request reprint Therapeutic potential of dietary phase 2 enzyme inducers in ameliorating diseases that have an underlying inflammatory component
    B H Juurlink
    Department of Anatomy and Cell Biology, The Cameco Multiple Sclerosis and Neuroscience Research Centre, College of Medicine, University of Saskatchewan, Saskatoon, Canada
    Can J Physiol Pharmacol 79:266-82. 2001
    ..Research should be directed into the potential therapeutic effects of dietary phase 2 enzyme inducers in ameliorating diseases with an underlying oxidative stress and inflammatory component to them...
  4. ncbi request reprint The multiple sclerosis lesion: initiated by a localized hypoperfusion in a central nervous system where mechanisms allowing leukocyte infiltration are readily upregulated?
    B H Juurlink
    Department of Anatomy and Cell Biology, Cameco Multiple Sclerosis and Neuroscience Research Centre, College of Medicine, University of Saskatchewan, Saskatoon, Canada
    Med Hypotheses 51:299-303. 1998
    ..Evidence supporting the proposed mechanism is presented, as well as suggestions on how to test the validity of the proposal...
  5. ncbi request reprint Inhibition of phosphoenolpyruvate carboxykinase (PEPCK) gene expression by troglitazone: a peroxisome proliferator-activated receptor-gamma (PPARgamma)-independent, antioxidant-related mechanism
    G F Davies
    Department of Biochemistry, University of Saskatchewan, 107 Wiggins Road, Saskatchewan S7N 5E5, Saskatoon, Canada
    Biochem Pharmacol 62:1071-9. 2001
    ..These observations support the conclusion that troglitazone inhibits the expression of the PEPCK gene by a PPARgamma-independent, antioxidant-related mechanism...
  6. ncbi request reprint Promoting glutathione synthesis after spinal cord trauma decreases secondary damage and promotes retention of function
    H Kamencic
    Department of Anatomy, University of Saskatchewan, Saskatoon, SK, Canada
    FASEB J 15:243-250. 2001
    ..3, and 12.9). We conclude that administration of OTC after spinal cord trauma greatly decreases oxidative stress and allows tissue preservation, thereby enabling otherwise paraplegic animals to locomote...
  7. ncbi request reprint The impaired glutathione system and its up-regulation by sulforaphane in vascular smooth muscle cells from spontaneously hypertensive rats
    L Wu
    Department of Anatomy and Cell Biology, College of Medicine, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK, Canada S7N 5E5
    J Hypertens 19:1819-25. 2001
    ..We conclude that SHR SMCs experience greater oxidative stress than WKY SMCs and that malfunction of the GSH system contributes to the enhanced oxidative stress in SHR SMCs...
  8. ncbi request reprint Sulfur amino acid deficiency depresses brain glutathione concentration
    P G Paterson
    College of Pharmacy and Nutrition, Cameco Multiple Sclerosis and Neuroscience Research Center, University of Saskatchewan, Saskatoon, Canada
    Nutr Neurosci 4:213-22. 2001
    ..The depletion of brain GSH by a reduced supply of dietary precursors may be important during brain ischemia when the rate of GSH utilization and the need for synthesis are increased...
  9. doi request reprint Memory and survival after microbeam radiation therapy
    Elisabeth Schultke
    University of Saskatchewan, Saskatoon, 107 Wiggins Road, Saskatoon, SK S7N 5E5, Canada
    Eur J Radiol 68:S142-6. 2008
    ..Experiments in small animal models of malignant brain tumour using synchrotron-based microbeam radiation therapy (MRT) have shown a promising prolongation of survival times...
  10. ncbi request reprint Troglitazone selectively inhibits glyoxalase I gene expression
    L Wu
    Department of Anatomy and Cell Biology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada
    Diabetologia 44:2004-12. 2001
    ..This inhibition of the glyoxalase system could contribute to troglitazone's hepatotoxic action which has previously been reported in a small percentage of individuals...
  11. doi request reprint Health effects with consumption of the flax lignan secoisolariciresinol diglucoside
    Jennifer L Adolphe
    College of Pharmacy and Nutrition, University of Saskatchewan, 110 Science Place, Saskatoon, SK, Canada S7N 5C9
    Br J Nutr 103:929-38. 2010
    ..The present review discusses the potential health benefits of SDG in humans, with supporting evidence from animal studies, and offers suggestions for future research...
  12. ncbi request reprint Constitutive nuclear localization of activated caspase 3 in subpopulations of the astroglial family of cells
    Mohammad Hossein Noyan-Ashraf
    Department of Anatomy and Cell Biology, University of Saskatchewan, Saskatoon, Canada
    Glia 49:588-93. 2005
    ..We conclude that Bergmann glia and a subpopulation of astrocytes throughout the CNS express activated caspase 3 in nuclei to fulfill a yet-to-be defined non-apoptotic function. GLIA...
  13. ncbi request reprint Dietary approaches to positively influence fetal determinants of adult health
    Mohammad Hossein Noyan-Ashraf
    Department of Anatomy and Cell Biology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    FASEB J 20:371-3. 2006
    ..We conclude that reducing oxidative stress in pregnant females has profound outcomes in the health of their adult offspring...
  14. ncbi request reprint The effect of glutamine on locomotor performance and skeletal muscle myosins following spinal cord injury in rats
    Jamie D Golding
    Department of Anatomy and Cell Biology, College of Medicine, University of Saskatchewan, Rm A315 Health Science Bldg, 107 Wiggins Road, Saskatoon, Saskatchewan, Canada S7N 5E5
    J Appl Physiol 101:1045-52. 2006
    ..Our findings suggest glutamine improves functional recovery and helps preserve myosin profile by reducing secondary SCI, thereby maintaining more nerves...
  15. ncbi request reprint Phase 2 protein inducers in the diet promote healthier aging
    Mohammad Hossein Noyan-Ashraf
    Department of Anatomy and Cell Biology, College of Medicine, University of Saskatchewan, Saskatoon, Canada
    J Gerontol A Biol Sci Med Sci 63:1168-76. 2008
    ..We conclude that simple changes in the diet such as incorporation of phase 2 protein inducers can have a profound influence on health and, thereby, the aging process...
  16. ncbi request reprint The effects of dietary sulfur amino acid deficiency on rat brain glutathione concentration and neural damage in global hemispheric hypoxia-ischemia
    P Joan Bobyn
    College of Pharmacy and Nutrition, University of Saskatchewan, 110 Science Place, Saskatoon, Sask, S7N 5C9, Canada
    Nutr Neurosci 5:407-16. 2002
    ..These findings suggest that well-nourished but not "deficient" animals tolerate a mild brain insult. The decline in brain glutathione in the "deficient" animals may be one of several contributing mechanisms...