D M Juriloff

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. ncbi request reprint The open-eyelid mutation, lidgap-Gates, is an eight-exon deletion in the mouse Map3k1 gene
    Diana M Juriloff
    Department of Medical Genetics, University of British Columbia, 6174 University Boulevard, Vancouver, BC, Canada V6T 1Z3
    Genomics 85:139-42. 2005
  2. ncbi request reprint Investigations of the genomic region that contains the clf1 mutation, a causal gene in multifactorial cleft lip and palate in mice
    Diana M Juriloff
    Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
    Birth Defects Res A Clin Mol Teratol 73:103-13. 2005
  3. ncbi request reprint Mouse models for neural tube closure defects
    D M Juriloff
    Department of Medical Genetics, University of British Columbia, 6174 University Boulevard, Vancouver, British Columbia, Canada
    Hum Mol Genet 9:993-1000. 2000
  4. ncbi request reprint A digenic cause of cleft lip in A-strain mice and definition of candidate genes for the two loci
    Diana M Juriloff
    Department of Medical Genetics, University of British Columbia, Vancouver, British ColumbiaV6T 1Z3, Canada
    Birth Defects Res A Clin Mol Teratol 70:509-18. 2004
  5. ncbi request reprint Multifactorial genetics of exencephaly in SELH/Bc mice
    D M Juriloff
    Department of Medical Genetics, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada
    Teratology 64:189-200. 2001
  6. ncbi request reprint Unravelling the complex genetics of cleft lip in the mouse model
    D M Juriloff
    Department of Medical Genetics, University of British Columbia, 6174 University Boulevard, Vancouver, B C, V6T 1Z3, Canada
    Mamm Genome 12:426-35. 2001
  7. ncbi request reprint Gaping lids, gp, a mutation on centromeric chromosome 11 that causes defective eyelid development in mice
    D M Juriloff
    Department of Medical Genetics, University of British Columbia, 6174 University Boulevard, Vancouver, British Columbia V6T 1Z3, Canada
    Mamm Genome 11:440-7. 2000
  8. ncbi request reprint Wnt9b is the mutated gene involved in multifactorial nonsyndromic cleft lip with or without cleft palate in A/WySn mice, as confirmed by a genetic complementation test
    Diana M Juriloff
    Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
    Birth Defects Res A Clin Mol Teratol 76:574-9. 2006
  9. doi request reprint Mouse genetic models of cleft lip with or without cleft palate
    Diana M Juriloff
    Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
    Birth Defects Res A Clin Mol Teratol 82:63-77. 2008
  10. ncbi request reprint Nonallelic noncomplementation models in mice: the first arch and lidgap-Gates mutations
    M J Harris
    Department of Medical Genetics, University of British Columbia, Vancouver, Canada
    Genome 41:789-96. 1998

Collaborators

Detail Information

Publications28

  1. ncbi request reprint The open-eyelid mutation, lidgap-Gates, is an eight-exon deletion in the mouse Map3k1 gene
    Diana M Juriloff
    Department of Medical Genetics, University of British Columbia, 6174 University Boulevard, Vancouver, BC, Canada V6T 1Z3
    Genomics 85:139-42. 2005
    ..The lg(Ga) mutation is consistent with a pattern suggesting that the waves of mutation in BALB/cGa and its descendants tend to be large deletions or ETn insertions, whose elevated rate of occurrence is due to an unknown mechanism...
  2. ncbi request reprint Investigations of the genomic region that contains the clf1 mutation, a causal gene in multifactorial cleft lip and palate in mice
    Diana M Juriloff
    Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
    Birth Defects Res A Clin Mol Teratol 73:103-13. 2005
    ..A potentially homologous gene, clf1 on distal chromosome 11, is part of the digenic cause of the 10-30% CL(P) in the A/WySn mouse strain. Here we report our progress toward identifying the clf1 mutation...
  3. ncbi request reprint Mouse models for neural tube closure defects
    D M Juriloff
    Department of Medical Genetics, University of British Columbia, 6174 University Boulevard, Vancouver, British Columbia, Canada
    Hum Mol Genet 9:993-1000. 2000
    ....
  4. ncbi request reprint A digenic cause of cleft lip in A-strain mice and definition of candidate genes for the two loci
    Diana M Juriloff
    Department of Medical Genetics, University of British Columbia, Vancouver, British ColumbiaV6T 1Z3, Canada
    Birth Defects Res A Clin Mol Teratol 70:509-18. 2004
    ..Our previous studies mapped two loci: clf1 on Chr11 and clf2 on Chr13--with a strong genetic maternal effect on the level of risk. Here we test the hypothesis that CL(P) is digenic and identify candidate genes for clf1 and clf2...
  5. ncbi request reprint Multifactorial genetics of exencephaly in SELH/Bc mice
    D M Juriloff
    Department of Medical Genetics, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada
    Teratology 64:189-200. 2001
    ..The SELH/Bc mouse strain has 10-30% exencephaly and is an animal model for human neural tube closure defects. This study examined the number of causative genes, their dominance relationships, and linkage map positions...
  6. ncbi request reprint Unravelling the complex genetics of cleft lip in the mouse model
    D M Juriloff
    Department of Medical Genetics, University of British Columbia, 6174 University Boulevard, Vancouver, B C, V6T 1Z3, Canada
    Mamm Genome 12:426-35. 2001
    ..Human homologs of clf1 and clf2 are expected to be on 17q and 5q/9q...
  7. ncbi request reprint Gaping lids, gp, a mutation on centromeric chromosome 11 that causes defective eyelid development in mice
    D M Juriloff
    Department of Medical Genetics, University of British Columbia, 6174 University Boulevard, Vancouver, British Columbia V6T 1Z3, Canada
    Mamm Genome 11:440-7. 2000
    ..The gaping lids mutation identifies a previously unknown locus on proximal Chromosome (Chr) 11 that has a strong role in fetal eyelid growth...
  8. ncbi request reprint Wnt9b is the mutated gene involved in multifactorial nonsyndromic cleft lip with or without cleft palate in A/WySn mice, as confirmed by a genetic complementation test
    Diana M Juriloff
    Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
    Birth Defects Res A Clin Mol Teratol 76:574-9. 2006
    ..Independently a recessive knockout mutation of Wnt9b (Wnt9b-) was reported to cause a lethal syndrome that includes some CLP...
  9. doi request reprint Mouse genetic models of cleft lip with or without cleft palate
    Diana M Juriloff
    Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
    Birth Defects Res A Clin Mol Teratol 82:63-77. 2008
    ....
  10. ncbi request reprint Nonallelic noncomplementation models in mice: the first arch and lidgap-Gates mutations
    M J Harris
    Department of Medical Genetics, University of British Columbia, Vancouver, Canada
    Genome 41:789-96. 1998
    ..Based on our data on open eyelids at birth, we suggest that false allelism may be common in mammalian birth defects that result from failure to meet developmental thresholds, even when the "causal" mutations are Mendelian...
  11. ncbi request reprint The major locus for multifactorial nonsyndromic cleft lip maps to mouse chromosome 11
    D M Juriloff
    Department of Medical Genetics, University of British Columbia, Vancouver, Canada
    Mamm Genome 6:63-9. 1995
    ..This locus, here named clf1 (cleft lip) maps to Chromosome (Chr) 11 to a region having linkage homology with human 17q21-24, supporting reports of association of human CL(P) with the retinoic acid receptor alpha (RARA) locus...
  12. ncbi request reprint The first arch (Far) mutation in mice recombines with Hoxd and Mdk
    R T Dreger
    Department of Medical Genetics, University of British Columbia, Vancouver, Canada
    Mamm Genome 6:662-3. 1995
  13. ncbi request reprint Three spontaneous mutations at the albino locus in SELH/Bc mice
    D M Juriloff
    Department of Medical Genetics, University of British Columbia, Vancouver, Canada
    Genome 37:190-7. 1994
    ..SELH/Bc mice may provide an animal model for the study of mechanisms underlying genetic instability...
  14. ncbi request reprint The lidgap-Gates (lgGa) mutation for open eyelids at birth maps to mouse chromosome 13
    D M Juriloff
    Department of Medical Genetics, University of British Columbia, Canada
    Mamm Genome 7:403-7. 1996
    ..Evidence is also presented for a common unlinked recessive suppressor of the open eyelids trait caused by lgGa...
  15. ncbi request reprint Current status of genetic linkage studies of a major gene that causes CL(P) in mice: exclusion map
    D M Juriloff
    Department of Medical Genetics, University of British Columbia, Vancouver, Canada
    J Craniofac Genet Dev Biol 13:223-9. 1993
    ..More than 40% of the mouse genome has been swept. Some candidate regions include mouse chromosomes 12, 18, and 19, and candidate loci on other chromosomes should include Rara, Tgfa, Bmp2b1, and Igf-2...
  16. ncbi request reprint Disruption of pattern formation in palatal rugae in fetal mice heterozygous for First arch (Far)
    M J Harris
    Department of Medical Genetics, University of British Columbia, Vancouver, Canada
    J Craniofac Genet Dev Biol 10:363-71. 1990
    ..The First arch mutation, which in heterozygotes disrupts pattern formation in both palatal rugae and maxillary vibrissae, can be used to study genetic control of pattern formation in mammalian embryos...
  17. ncbi request reprint Genetic analysis of the construction of the AEJ.A congenic strain indicates that nonsyndromic CL(P) in the mouse is caused by two loci with epistatic interaction
    D M Juriloff
    Department of Medical Genetics, University of British Columbia, Vancouver, Canada
    J Craniofac Genet Dev Biol 15:1-12. 1995
    ....
  18. ncbi request reprint Genetic landmarks for defects in mouse neural tube closure
    M J Harris
    Department of Medical Genetics, University of British Columbia, Vancouver, Canada
    Teratology 56:177-87. 1997
    ....
  19. ncbi request reprint Mapping the mouse craniofacial mutation first arch (Far) to chromosome 2
    D M Juriloff
    Department of Medical Genetics, University of British Columbia, Vancouver, B C Canada
    J Hered 82:402-5. 1991
    ..It may therefore be significant that, in mapping near Ulnaless, Far also maps in the vicinity of the Hox-4 gene cluster...
  20. ncbi request reprint Studies of a spontaneous lethal mutation at the albino locus in SELH/Bc mice
    D M Juriloff
    Department of Medical Genetics, University of British Columbia, Vancouver, Canada
    Genome 35:342-6. 1992
    ..This lethal albino mutation that appears to be a postmeiotic deletion should be useful in the search for the mechanism of mutagenesis in SELH/Bc mice. It may also be useful in mapping essential genes in the c-locus region...
  21. ncbi request reprint Mouse mutants with neural tube closure defects and their role in understanding human neural tube defects
    Muriel J Harris
    Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
    Birth Defects Res A Clin Mol Teratol 79:187-210. 2007
    ..The number of mouse mutants and strains with neural tube closure defects (NTDs) now exceeds 190, including 155 involving known genes, 33 with unidentified genes, and eight "multifactorial" strains...
  22. ncbi request reprint Maternal diet alters exencephaly frequency in SELH/Bc strain mouse embryos
    Muriel J Harris
    Department of Medical Genetics, University of British Columbia, Vancouver, Canada
    Birth Defects Res A Clin Mol Teratol 73:532-40. 2005
    ..The SELH/Bc mouse inbred strain, with a high frequency of nonsyndromic, genetically-multifactorial exencephaly, is a model for human cranial neural tube defects (NTDs). Maternal diet affects risk of human NTDs...
  23. doi request reprint An update to the list of mouse mutants with neural tube closure defects and advances toward a complete genetic perspective of neural tube closure
    Muriel J Harris
    Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
    Birth Defects Res A Clin Mol Teratol 88:653-69. 2010
    ....
  24. ncbi request reprint Whiskers amiss, a new vibrissae and hair mutation near the Krt1 cluster on mouse chromosome 11
    L A Taylor
    Department of Medical Genetics, University of British Columbia, Vancouver, Canada
    Mamm Genome 11:255-9. 2000
    ..The SELH/Bc strain background appears to have an unusually high rate of spontaneous mutation; wam is the sixth mutation to be described...
  25. ncbi request reprint Mini-review: toward understanding mechanisms of genetic neural tube defects in mice
    M J Harris
    Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
    Teratology 60:292-305. 1999
    ....
  26. ncbi request reprint Is Far a Hox mutation?
    D M Juriloff
    Department of Medical Genetics, University of British Columbia, Vancouver, Canada
    J Craniofac Genet Dev Biol 12:119-29. 1992
    ..abstract truncated at 400 words)..
  27. pmc Structure and expression of mobile ETnII retroelements and their coding-competent MusD relatives in the mouse
    Corinna Baust
    Terry Fox Laboratory, B C Cancer Agency, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
    J Virol 77:11448-58. 2003
    ..We also show that ETnII is expressed up to 30-fold more than MusD, which could explain why only ETnII, but not MusD, elements have been positively identified as new insertions...
  28. doi request reprint Accelerated embryonic development associated with increased risk of neural tube defects induced by maternal diet in offspring of SELH/Bc mice
    Katharine L Stoate
    Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
    Birth Defects Res A Clin Mol Teratol 82:720-7. 2008
    ..Maternal diets affect SELH/Bc exencephaly rates: 25-35% on Purina Diet 5015 versus 5-10% on Purina Diet 5001. We hypothesized that in SELH/Bc, the diets affect maternal blood glucose and embryonic developmental rate...