R Brad Jones

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. pmc Nucleoside analogue reverse transcriptase inhibitors differentially inhibit human LINE-1 retrotransposition
    R Brad Jones
    Department of Immunology, University of Toronto, Medical Sciences Building, Toronto, Ontario, Canada
    PLoS ONE 3:e1547. 2008
  2. pmc Human endogenous retrovirus K(HML-2) Gag and Env specific T-cell responses are not detected in HTLV-I-infected subjects using standard peptide screening methods
    R Brad Jones
    Department of Immunology, University of Toronto, 1 King s College Circle, Rm 6352, Toronto, ON M5S 1A8, Canada
    J Negat Results Biomed 12:3. 2013
  3. pmc Short communication: HIV type 1 accumulates in influenza-specific T cells in subjects receiving seasonal vaccination in the context of effective antiretroviral therapy
    R Brad Jones
    Department of Immunology, University of Toronto, Medical Sciences Building, Toronto, Ontario, Canada
    AIDS Res Hum Retroviruses 28:1687-92. 2012
  4. pmc Human endogenous retrovirus K(HML-2) Gag- and Env-specific T-cell responses are infrequently detected in HIV-1-infected subjects using standard peptide matrix-based screening
    R Brad Jones
    Department of Immunology, University of Toronto, Toronto, Ontario, Canada
    Clin Vaccine Immunol 19:288-92. 2012
  5. pmc Human immunodeficiency virus type 1 escapes from interleukin-2-producing CD4+ T-cell responses without high-frequency fixation of mutations
    R Brad Jones
    Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada
    J Virol 83:8722-32. 2009
  6. pmc Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection
    R Brad Jones
    Department of Immunology, University of Toronto, Toronto, ON, Canada
    J Exp Med 205:2763-79. 2008
  7. doi request reprint HCV-specific T cells in HCV/HIV co-infection show elevated frequencies of dual Tim-3/PD-1 expression that correlate with liver disease progression
    Bahareh Vali
    Institute of Medical Science, University of Toronto, Toronto, ON, Canada
    Eur J Immunol 40:2493-505. 2010
  8. doi request reprint Antigen-independent induction of Tim-3 expression on human T cells by the common γ-chain cytokines IL-2, IL-7, IL-15, and IL-21 is associated with proliferation and is dependent on the phosphoinositide 3-kinase pathway
    Shariq Mujib
    Institute of Medical Sciences, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Immunol 188:3745-56. 2012
  9. doi request reprint HIV-specific IL-21 producing CD4+ T cells are induced in acute and chronic progressive HIV infection and are associated with relative viral control
    Feng Yun Yue
    Clinical Sciences Division, St Michael s Hospital, University of Toronto, Canada
    J Immunol 185:498-506. 2010
  10. pmc HERV-K-specific T cells eliminate diverse HIV-1/2 and SIV primary isolates
    R Brad Jones
    Department of Immunology, University of Toronto, and Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
    J Clin Invest 122:4473-89. 2012

Collaborators

Detail Information

Publications15

  1. pmc Nucleoside analogue reverse transcriptase inhibitors differentially inhibit human LINE-1 retrotransposition
    R Brad Jones
    Department of Immunology, University of Toronto, Medical Sciences Building, Toronto, Ontario, Canada
    PLoS ONE 3:e1547. 2008
    ..LINE-1 element activity may also play a role in normal physiology...
  2. pmc Human endogenous retrovirus K(HML-2) Gag and Env specific T-cell responses are not detected in HTLV-I-infected subjects using standard peptide screening methods
    R Brad Jones
    Department of Immunology, University of Toronto, 1 King s College Circle, Rm 6352, Toronto, ON M5S 1A8, Canada
    J Negat Results Biomed 12:3. 2013
    ..Intriguingly, numerous studies have implicated these same HERV families in MS, though this association remains controversial...
  3. pmc Short communication: HIV type 1 accumulates in influenza-specific T cells in subjects receiving seasonal vaccination in the context of effective antiretroviral therapy
    R Brad Jones
    Department of Immunology, University of Toronto, Medical Sciences Building, Toronto, Ontario, Canada
    AIDS Res Hum Retroviruses 28:1687-92. 2012
    ..This has implications for the eradication of HIV-1 by adding to the evidence that the resting CD4(+) T cell viral reservoir is continually replenished in ART-treated subjects...
  4. pmc Human endogenous retrovirus K(HML-2) Gag- and Env-specific T-cell responses are infrequently detected in HIV-1-infected subjects using standard peptide matrix-based screening
    R Brad Jones
    Department of Immunology, University of Toronto, Toronto, Ontario, Canada
    Clin Vaccine Immunol 19:288-92. 2012
    ..Thus, HERV-K(HML-2) Gag- and Env-specific T-cell responses are infrequently detected by 15 mer peptide mapping...
  5. pmc Human immunodeficiency virus type 1 escapes from interleukin-2-producing CD4+ T-cell responses without high-frequency fixation of mutations
    R Brad Jones
    Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada
    J Virol 83:8722-32. 2009
    ....
  6. pmc Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection
    R Brad Jones
    Department of Immunology, University of Toronto, Toronto, ON, Canada
    J Exp Med 205:2763-79. 2008
    ..Blocking the Tim-3 signaling pathway restored proliferation and enhanced cytokine production in HIV-1-specific T cells. Thus, Tim-3 represents a novel target for the therapeutic reversal of HIV-1-associated T cell dysfunction...
  7. doi request reprint HCV-specific T cells in HCV/HIV co-infection show elevated frequencies of dual Tim-3/PD-1 expression that correlate with liver disease progression
    Bahareh Vali
    Institute of Medical Science, University of Toronto, Toronto, ON, Canada
    Eur J Immunol 40:2493-505. 2010
    ..These data demonstrate that co-expression of Tim-3 and PD-1 may play a significant role in HCV-specific T-cell dysfunction, especially in the setting of HIV co-infection...
  8. doi request reprint Antigen-independent induction of Tim-3 expression on human T cells by the common γ-chain cytokines IL-2, IL-7, IL-15, and IL-21 is associated with proliferation and is dependent on the phosphoinositide 3-kinase pathway
    Shariq Mujib
    Institute of Medical Sciences, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Immunol 188:3745-56. 2012
    ..The upregulation of Tim-3 could be blocked by the addition of a PI3K inhibitor, LY 294002. Thus, Tim-3 can be induced via TCR/CD28 costimulation and/or γc cytokines, likely through the PI3K pathway...
  9. doi request reprint HIV-specific IL-21 producing CD4+ T cells are induced in acute and chronic progressive HIV infection and are associated with relative viral control
    Feng Yun Yue
    Clinical Sciences Division, St Michael s Hospital, University of Toronto, Canada
    J Immunol 185:498-506. 2010
    ..Thus, IL-21-producing CD4(+) T cells are induced in viremic HIV infection and likely contribute to viral control by affecting CD8(+) T cell maintenance...
  10. pmc HERV-K-specific T cells eliminate diverse HIV-1/2 and SIV primary isolates
    R Brad Jones
    Department of Immunology, University of Toronto, and Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
    J Clin Invest 122:4473-89. 2012
    ..This justifies the consideration of HERV-K(HML-2)-specific and cross-reactive T cell responses in the natural control of HIV-1 infection and for exploring HERV-K(HML-2)-targeted HIV-1 vaccines and immunotherapeutics...
  11. doi request reprint Persistent HIV RNA shedding in semen despite effective antiretroviral therapy
    Prameet M Sheth
    Department of Medicine, Dalla Lana School of Public Health, Toronto, Ontario, Canada
    AIDS 23:2050-4. 2009
    ..Isolates were drug-sensitive, and this phenomenon was not associated with semen drug levels or regimen...
  12. pmc HIV-specific T-cells accumulate in the liver in HCV/HIV co-infection
    Bahareh Vali
    Institute of Medical Science, Department of Medicine, University of Toronto, Toronto, Canada
    PLoS ONE 3:e3454. 2008
    ..We examined whether HIV-specific T-cells are identified in the liver of HCV/HIV co-infected individuals and promote liver inflammation through bystander immune responses...
  13. pmc CD40L expressed from the canarypox vector, ALVAC, can boost immunogenicity of HIV-1 canarypox vaccine in mice and enhance the in vitro expansion of viral specific CD8+ T cell memory responses from HIV-1-infected and HIV-1-uninfected individuals
    Jun Liu
    Clinical Sciences Division, University of Toronto, Toronto, Ontario, Canada
    Vaccine 26:4062-72. 2008
    ..Taken together, our results suggest that CD40L incorporation into poxvirus vectors could be used as a strategy to enhance their immunogenicity...
  14. pmc Loss of the signaling adaptor TRAF1 causes CD8+ T cell dysregulation during human and murine chronic infection
    Chao Wang
    Department of Immunology, 2 Clinical Sciences Division, University of Toronto, Toronto, M5S 1A8, Canada
    J Exp Med 209:77-91. 2012
    ..These findings identify TRAF1 as a potential biomarker of HIV-specific CD8 T cell fitness during the chronic phase of disease and a target for therapy...
  15. pmc Clinical and immunologic features of an atypical intracranial mycobacterium avium complex (MAC) infection compared with those of pulmonary MAC infections
    Mouhannad Sadek
    Clinical Sciences Division, Rm 6271, 1 King s College Circle, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    Clin Vaccine Immunol 15:1580-9. 2008
    ..Further studies delineating the potential role of TNF-alpha in limiting the spread of MAC outside the lung are warranted...