Peter Jh Jones

Summary

Affiliation: University of Manitoba
Country: Canada

Publications

  1. ncbi request reprint Consumption of an oil composed of medium chain triacyglycerols, phytosterols, and N-3 fatty acids improves cardiovascular risk profile in overweight women
    Christine Bourque
    School of Dietetics and Human Nutrition, McGill University, Ste Anne de Bellevue, Quebec, Canada
    Metabolism 52:771-7. 2003
  2. ncbi request reprint Dietary conjugated linoleic acid and body composition
    Yanwen Wang
    School of Dietetics and Human Nutrition, McGill University, Ste Anne de Bellevue, Quebec, Canada
    Am J Clin Nutr 79:1153S-1158S. 2004
  3. ncbi request reprint Intake of a single morning dose of standard and novel plant sterol preparations for 4 weeks does not dramatically affect plasma lipid concentrations in humans
    Suhad S AbuMweis
    School of Dietetics and Human Nutrition, McGill University, Montreal, Quebec, Canada
    J Nutr 136:1012-6. 2006
  4. doi request reprint Response to commentary on a trial comparing krill oil versus fish oil
    Vanu R Ramprasath
    Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, 196 Innovation Drive, Winnipeg MB R3T 2N2, Canada
    Lipids Health Dis 13:17. 2014
  5. doi request reprint Enhanced increase of omega-3 index in healthy individuals with response to 4-week n-3 fatty acid supplementation from krill oil versus fish oil
    Vanu R Ramprasath
    Richardson Centre for Functional Foods and Nutraceuticals, Winnipeg, Canada
    Lipids Health Dis 12:178. 2013
  6. pmc The effect of drinking milk containing conjugated linoleic acid on fecal microbiological profile, enzymatic activity, and fecal characteristics in humans
    Edward R Farnworth
    Food Research and Development Centre, Agriculture Canada, Saint Hyacinthe, Quebec, Canada
    Nutr J 6:15. 2007
  7. pmc Changes in cholesterol kinetics following sugar cane policosanol supplementation: a randomized control trial
    Amira N Kassis
    School of Dietetics and Human Nutrition, McGill University, Ste Anne de Bellevue, Montreal, Quebec, H9X 3V9, Canada
    Lipids Health Dis 7:17. 2008
  8. pmc Plant sterols, marine-derived omega-3 fatty acids and other functional ingredients: a new frontier for treating hyperlipidemia
    Christopher Pf Marinangeli
    Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, 196 Innovation Drive, Winnipeg MB, R3T 2N2, Canada
    Nutr Metab (Lond) 7:76. 2010
  9. doi request reprint Are functional foods redefining nutritional requirements?
    Peter J Jones
    Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, 196 Innovation Dr, Winnipeg, MB R3T 6C5
    Appl Physiol Nutr Metab 33:118-23. 2008
  10. ncbi request reprint Evidence for health claims on foods: how much is enough? Introduction and general remarks
    Peter J H Jones
    Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, Manitoba R3T 6C5, Canada
    J Nutr 138:1189S-91S. 2008

Collaborators

Detail Information

Publications92

  1. ncbi request reprint Consumption of an oil composed of medium chain triacyglycerols, phytosterols, and N-3 fatty acids improves cardiovascular risk profile in overweight women
    Christine Bourque
    School of Dietetics and Human Nutrition, McGill University, Ste Anne de Bellevue, Quebec, Canada
    Metabolism 52:771-7. 2003
    ..In conclusion, despite equivocal effects on homocysteine levels, consumption of a functional oil composed of MCT, phytosterols, and n-3 fatty acids for 27 days improves the overall cardiovascular risk profile of overweight women...
  2. ncbi request reprint Dietary conjugated linoleic acid and body composition
    Yanwen Wang
    School of Dietetics and Human Nutrition, McGill University, Ste Anne de Bellevue, Quebec, Canada
    Am J Clin Nutr 79:1153S-1158S. 2004
    ..This review addresses recent studies of the effects of CLA on lipid metabolism, fat deposition, and body composition in both animals and humans as well as the mechanisms surrounding these effects...
  3. ncbi request reprint Intake of a single morning dose of standard and novel plant sterol preparations for 4 weeks does not dramatically affect plasma lipid concentrations in humans
    Suhad S AbuMweis
    School of Dietetics and Human Nutrition, McGill University, Montreal, Quebec, Canada
    J Nutr 136:1012-6. 2006
    ....
  4. doi request reprint Response to commentary on a trial comparing krill oil versus fish oil
    Vanu R Ramprasath
    Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, 196 Innovation Drive, Winnipeg MB R3T 2N2, Canada
    Lipids Health Dis 13:17. 2014
    ....
  5. doi request reprint Enhanced increase of omega-3 index in healthy individuals with response to 4-week n-3 fatty acid supplementation from krill oil versus fish oil
    Vanu R Ramprasath
    Richardson Centre for Functional Foods and Nutraceuticals, Winnipeg, Canada
    Lipids Health Dis 12:178. 2013
    ....
  6. pmc The effect of drinking milk containing conjugated linoleic acid on fecal microbiological profile, enzymatic activity, and fecal characteristics in humans
    Edward R Farnworth
    Food Research and Development Centre, Agriculture Canada, Saint Hyacinthe, Quebec, Canada
    Nutr J 6:15. 2007
    ..The primary objective was to determine whether consumption of conjugated linoleic acids (CLAs) affected the fecal microbiota composition, fecal enzyme activity or fecal composition...
  7. pmc Changes in cholesterol kinetics following sugar cane policosanol supplementation: a randomized control trial
    Amira N Kassis
    School of Dietetics and Human Nutrition, McGill University, Ste Anne de Bellevue, Montreal, Quebec, H9X 3V9, Canada
    Lipids Health Dis 7:17. 2008
    ..Blood was collected on the first two and last five days of the trial. Cholesterol absorption and synthesis were determined by measuring red cell cholesterol 13C and deuterium enrichment, respectively...
  8. pmc Plant sterols, marine-derived omega-3 fatty acids and other functional ingredients: a new frontier for treating hyperlipidemia
    Christopher Pf Marinangeli
    Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, 196 Innovation Drive, Winnipeg MB, R3T 2N2, Canada
    Nutr Metab (Lond) 7:76. 2010
    ..Finally, this editorial aims to challenge current medical guidelines to emphasize efficacious FFN during all stages of treatment of hyperlipidemias as adjuncts to pharmacotherapy...
  9. doi request reprint Are functional foods redefining nutritional requirements?
    Peter J Jones
    Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, 196 Innovation Dr, Winnipeg, MB R3T 6C5
    Appl Physiol Nutr Metab 33:118-23. 2008
    ..Such discrepancies emphasize the need for a more all-encompassing definition of a nutrient requirement; that is, one that moves beyond the prevention of overt deficiency to encompass improved health and disease risk reduction...
  10. ncbi request reprint Evidence for health claims on foods: how much is enough? Introduction and general remarks
    Peter J H Jones
    Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, Manitoba R3T 6C5, Canada
    J Nutr 138:1189S-91S. 2008
  11. ncbi request reprint Phytosterols as functional food ingredients: linkages to cardiovascular disease and cancer
    Peter J H Jones
    Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, Smartpark, Winnipeg, Manitoba, Canada
    Curr Opin Clin Nutr Metab Care 12:147-51. 2009
    ..To examine experimental evidence that has examined association of phytosterols and the reduction of the risk of cardiovascular disease and cancer...
  12. doi request reprint The effect of dietary oleic, linoleic, and linolenic acids on fat oxidation and energy expenditure in healthy men
    Peter J H Jones
    Faculty of Agriculture and Environmental Sciences, School of Dietetics and Human Nutrition, McGill University, Quebec, Canada H9X 3V9
    Metabolism 57:1198-203. 2008
    ..In conclusion, diets rich in oleic acid derived from olive oil may offer increased oxidation translating into increased energy expenditure postprandially...
  13. ncbi request reprint Fish-oil esters of plant sterols improve the lipid profile of dyslipidemic subjects more than do fish-oil or sunflower oil esters of plant sterols
    Isabelle Demonty
    School of Dietetics and Human Nutrition, McGill University, Sainte Anne de Bellevue, Canada
    Am J Clin Nutr 84:1534-42. 2006
    ..Fish-oil fatty acid esters of plant sterols (FO-PS) were shown to have hypotriglyceridemic and hypocholesterolemic properties in animal models...
  14. doi request reprint High basal fractional cholesterol synthesis is associated with nonresponse of plasma LDL cholesterol to plant sterol therapy
    Todd C Rideout
    Richardson Centre for Functional Foods and Nutraceuticals, Winnipeg, Canada
    Am J Clin Nutr 92:41-6. 2010
    ..To capitalize on the LDL-cholesterol-lowering potential of PS in the clinical setting, it is paramount to characterize the metabolic factors that underlie this heterogeneity of responsiveness...
  15. ncbi request reprint Phytosterols mixed with medium-chain triglycerides and high-oleic canola oil decrease plasma lipids in overweight men
    Iwona Rudkowska
    School of Dietetics and Human Nutrition, Faculty of Agricultural and Environmental Sciences, McGill University, Montreal, Quebec, Canada H9X 3V9
    Metabolism 55:391-5. 2006
    ....
  16. ncbi request reprint Effects of a medium chain triglyceride oil mixture and alpha-lipoic acid diet on body composition, antioxidant status, and plasma lipid levels in the Golden Syrian hamster
    Stephanie D Wollin
    School of Dietetics and Human Nutrition, McGill University, 21, 111 Lakeshore Rd, Ste Anne de Bellevue, Quebec, Canada H9X 3V9
    J Nutr Biochem 15:402-10. 2004
    ..However, our results do support the existence of beneficial effects of ALP on circulating lipoprotein content in the hamster...
  17. pmc Kefir consumption does not alter plasma lipid levels or cholesterol fractional synthesis rates relative to milk in hyperlipidemic men: a randomized controlled trial [ISRCTN10820810]
    Marie Pierre St-Onge
    School of Dietetics and Human Nutrition, McGill University, Ste Anne de Bellevue, Canada
    BMC Complement Altern Med 2:1. 2002
    ..Kefir, a fermented milk product, has been traditionally consumed for its potential health benefits but has to date not been studied for its hypocholesterolemic properties...
  18. ncbi request reprint Medium-chain triglycerides increase energy expenditure and decrease adiposity in overweight men
    Marie Pierre St-Onge
    School of Dietetics and Human Nutrition, McGill University, Ste Anne de Bellevue, Quebec, Canada
    Obes Res 11:395-402. 2003
    ....
  19. pmc Low and moderate-fat plant sterol fortified soymilk in modulation of plasma lipids and cholesterol kinetics in subjects with normal to high cholesterol concentrations: report on two randomized crossover studies
    Todd C Rideout
    Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, Manitoba R3T6C5, Canada
    Lipids Health Dis 8:45. 2009
    ..Both the low and moderate-fat PS-enriched soymilk varieties provided 1.95 g PS/d. Endpoint plasma variables were analyzed by repeated-measures ANOVA using baseline values as covariates for plasma lipid measurements...
  20. ncbi request reprint Olive oil containing olive oil fatty acid esters of plant sterols and dietary diacylglycerol reduces low-density lipoprotein cholesterol and decreases the tendency for peroxidation in hypercholesterolaemic subjects
    Yen Ming Chan
    The School of Dietetics and Human Nutrition, McGill University, Macdonald Campus, 21, 111 Lakeshore Road, Sainte Anne de Bellevue, Quebec, Canada H9X 3V9
    Br J Nutr 98:563-70. 2007
    ..Our results suggest that supplementing an OO-rich diet with PS-OO favourably alters the plasma lipid profile and may decrease the susceptibility of LDL-C to lipid peroxidation in hypercholesterolaemic subjects...
  21. doi request reprint Policosanols as nutraceuticals: fact or fiction
    Christopher P F Marinangeli
    Richardson Centre for Functional Foods and Nutraceuticals, Department of Food Science, University of Manitoba, Winnipeg, Manitoba, Canada
    Crit Rev Food Sci Nutr 50:259-67. 2010
    ..The absence of independent and external studies confirming the therapeutic benefits of PC in disease prevention and treatment raises questions regarding their true efficacy...
  22. doi request reprint Efficacy of plant sterols is not influenced by dietary cholesterol intake in hypercholesterolemic individuals
    Amira N Kassis
    School of Dietetics and Human Nutrition, McGill University, Ste Anne de Bellevue, Montreal, Quebec, Canada
    Metabolism 57:339-46. 2008
    ..0001) as a result of PS supplementation. Data from the present study indicate that, although PSs and dietary cholesterol exert independent effects on plasma cholesterol, PS efficacy is not affected by varying levels of cholesterol intake...
  23. ncbi request reprint Cholesterol-lowering efficacy of plant sterols in low-fat yogurt consumed as a snack or with a meal
    Iwona Rudkowska
    School of Dietetics and Human Nutrition, Faculty of Agricultural and Environmental Sciences, McGill University, Ste Anne de Bellevue, Quebec, Canada
    J Am Coll Nutr 27:588-95. 2008
    ..6 g/d) with a meal over an afternoon snack will lead to favourable changes in plasma lipids, plasma PS concentrations, and cholesterol synthesis without negatively affecting alpha-tocopherol or carotenoids levels...
  24. ncbi request reprint Structured medium and long chain triglycerides show short-term increases in fat oxidation, but no changes in adiposity in men
    Catherine E Roynette
    School of Dietetics and Human Nutrition, Faculty of Agricultural and Environmental Sciences, McGill University, 21, 111 Lakeshore Road, Ste Anne de Bellevue, QC, Canada
    Nutr Metab Cardiovasc Dis 18:298-305. 2008
    ..Medium chain triglycerides (MCT) have been suggested as modulators of human energy expenditure (EE) and thus may influence total and regional body fat distribution...
  25. ncbi request reprint Unesterified plant sterols and stanols lower LDL-cholesterol concentrations equivalently in hypercholesterolemic persons
    Catherine A Vanstone
    School of Dietetics and Human Nutrition, McGill University, Ste Anne de Bellevue, Quebec, Canada
    Am J Clin Nutr 76:1272-8. 2002
    ..Particularly controversial at present is the effect of the degree of hydrogenation of the plant sterols on cholesterol-lowering efficacy and the responsible mechanisms...
  26. doi request reprint Association between non-responsiveness to plant sterol intervention and polymorphisms in cholesterol metabolism genes: a case-control study
    Iwona Rudkowska
    School of Dietetics and Human Nutrition, Faculty of Agricultural and Environmental Sciences, McGill University, Ste Anne de Bellevue, QC, Canada
    Appl Physiol Nutr Metab 33:728-34. 2008
    ....
  27. ncbi request reprint Consumption of a functional oil rich in phytosterols and medium-chain triglyceride oil improves plasma lipid profiles in men
    Marie Pierre St-Onge
    School of Dietetics and Human Nutrition, McGill University, Ste Anne de Bellevue, Quebec, Canada, H9X 3V9
    J Nutr 133:1815-20. 2003
    ..Functional oil consumption can therefore help reduce the risk of cardiovascular disease...
  28. ncbi request reprint Corn fiber oil and sitostanol decrease cholesterol absorption independently of intestinal sterol transporters in hamsters
    Deepak Jain
    School of Dietetics and Human Nutrition, Macdonald Campus of McGill University, Ste Anne de Bellevue, QC, Canada
    J Nutr Biochem 19:229-36. 2008
    ..The aim of this study was to investigate the cholesterol-lowering mechanisms of corn fiber oil (CFO), ferulate phytostanyl esters (FPEs) and parent compounds of FPE, including sitostanol and ferulic acid, in hamsters...
  29. ncbi request reprint Lack of cholesterol-lowering efficacy of Cuban sugar cane policosanols in hypercholesterolemic persons
    Amira N Kassis
    School of Dietetics and Human Nutrition, McGill University, Ste Anne de Bellevue, Montreal, Quebec, Canada
    Am J Clin Nutr 84:1003-8. 2006
    ..However, several animal and human trials conducted outside of Cuba that used non-Cuban mixtures have failed to reproduce the efficacy of policosanols observed in earlier studies...
  30. pmc Fish-oil esters of plant sterols differ from vegetable-oil sterol esters in triglycerides lowering, carotenoid bioavailability and impact on plasminogen activator inhibitor-1 (PAI-1) concentrations in hypercholesterolemic subjects
    Peter J H Jones
    School of Dietetics and Human Nutrition, McGill University, Sainte Anne de Bellevue, Canada
    Lipids Health Dis 6:28. 2007
    ..Our objective was to compare the actions of different FA esterified to PS on blood lipids, carotenoid bioavailability as well as inflammatory and coagulation markers...
  31. ncbi request reprint Phytosterols and human lipid metabolism: efficacy, safety, and novel foods
    Marie Pierre St-Onge
    School of Dietetics and Human Nutrition, McGill University, Ste Anne de Bellevue, Quebec, Canada H9X 3V9
    Lipids 38:367-75. 2003
    ....
  32. ncbi request reprint Effect of plant sterols and exercise training on cholesterol absorption and synthesis in previously sedentary hypercholesterolemic subjects
    Krista A Varady
    School of Dietetics and Human Nutrition, Faculty of Agricultural and Environmental Sciences, McGill University, Montreal, Quebec, Canada
    Transl Res 149:22-30. 2007
    ..25, P=0.03). These findings suggest that exercise does not modulate lipid levels by altering to cholesterol absorption or synthesis, whereas plant sterols favorably alter levels of LDL cholesterol by suppressing intestinal absorption...
  33. doi request reprint Combination drug-diet therapies for dyslipidemia
    Todd C Rideout
    Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, Manitoba, Canada
    Transl Res 155:220-7. 2010
    ..Accordingly, this review will assess current limitations associated with both drug and diet lipid-lowering therapies and explore the potential of combination drug/diet therapies in the treatment of dyslipidemia...
  34. doi request reprint Consumption of plant sterols reduces plasma and hepatic triglycerides and modulates the expression of lipid regulatory genes and de novo lipogenesis in C57BL/6J mice
    Todd C Rideout
    Richardson Centre for Functional Foods and Nutraceuticals, Winnipeg, MB, Canada
    Mol Nutr Food Res 54:S7-13. 2010
    ..Interference with intestinal fatty acid/TAG metabolism as suggested by increased fecal fatty acid loss and reduced weight gain may be associated with the TAG-lowering response to PS consumption...
  35. doi request reprint Dietary oils and FADS1-FADS2 genetic variants modulate [13C]α-linolenic acid metabolism and plasma fatty acid composition
    Leah G Gillingham
    Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, Canada
    Am J Clin Nutr 97:195-207. 2013
    ..Desaturation of dietary α-linolenic acid (ALA) to omega-3 (n-3) long-chain fatty acids (FAs) is mediated through FA desaturases (FADS1-FADS2) and may be influenced by dietary FA composition...
  36. pmc Guar gum and similar soluble fibers in the regulation of cholesterol metabolism: current understandings and future research priorities
    Todd C Rideout
    Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, Manitoba, Canada
    Vasc Health Risk Manag 4:1023-33. 2008
    ....
  37. doi request reprint Cholesterol-lowering effects of oat β-glucan
    Rgia A Othman
    Department of Human Nutritional Sciences and Canadian Centre for Agri food Research in Health and Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Nutr Rev 69:299-309. 2011
    ..Significant scientific agreement continues to support a relationship between oat β-glucan and blood cholesterol levels, with newer data being consistent with earlier conclusions made by the FDA and JHCI...
  38. ncbi request reprint Hypocholesterolaemic effects of plant sterol analogues are independent of ABCG5 and ABCG8 transporter expressions in hamsters
    Xiaoming Jia
    School of Dietetics and Human Nutrition, McGill University, Macdonald Campus, 21, 111 Lakeshore, Ste Anne de Bellevue, QC, Canada, H9X 3V9, Canada
    Br J Nutr 98:550-5. 2007
    ..These results suggest that plant sterols and their derivatives reduce plasma cholesterol levels independently from the mRNA expression of ABCG5 and ABCG8 transporters...
  39. ncbi request reprint Functional foods for the prevention and treatment of cardiovascular diseases: cholesterol and beyond
    Iwona Rudkowska
    School of Dietetics and Human Nutrition McGill University, St Anne de Bellevue, Quebec, Canada
    Expert Rev Cardiovasc Ther 5:477-90. 2007
    ..Overall, these functional foods should be considered as an addition to current lipid-lowering recommendations for improving CVD risk...
  40. ncbi request reprint Plant sterols combined with exercise for the treatment of hypercholesterolemia: overview of independent and synergistic mechanisms of action
    Christopher P F Marinangeli
    School of Dietetics and Human Nutrition, McGill University, Quebec, Canada
    J Nutr Biochem 17:217-24. 2006
    ..In sum, the present review lends further insight as to the metabolic benefits of adopting a healthy lifestyle, including plant sterols and endurance training, in the treatment of dyslipidemia...
  41. ncbi request reprint An investigation of hormone and lipid associations after weight loss in women
    Sylvia Santosa
    School of Dietetics and Human Nutrition, McGill University, Montreal, Canada
    J Am Coll Nutr 26:250-8. 2007
    ....
  42. ncbi request reprint Validation of a single-isotope-labeled cholesterol tracer approach for measuring human cholesterol absorption
    Yanwen Wang
    School of Dietetics and Human Nutrition, McGill University, Ste Anne de Bellevue, Quebec, Canada, H9X 3V9
    Lipids 39:87-91. 2004
    ..These results suggest that a single-isotope-labeled cholesterol tracer approach can be used as a reliable noninvasive method to replace PDSIRM for examining changes in cholesterol absorption...
  43. ncbi request reprint Phytosterols in low- and nonfat beverages as part of a controlled diet fail to lower plasma lipid levels
    Peter J H Jones
    School of Dietetics and Human Nutrition, McGill University, Ste Anne de Bellevue, Quebec, Canada H9X 3V9
    J Lipid Res 44:1713-9. 2003
    ..These results show that intake of phytosterols in a low-fat beverage format is not efficacious for lipid level modification...
  44. ncbi request reprint Role of isoflavones in the hypocholesterolemic effect of soy
    Isabelle Demonty
    School of Dietetics and Human Nutrition, Macdonald Campus of McGill University, Ste Anne de Bellevue, Quebec, Canada, H9X 3V9
    Nutr Rev 61:189-203. 2003
    ..There are currently not enough data to recommend the consumption of isoflavone supplements to lower plasma cholesterol levels...
  45. ncbi request reprint Unesterified plant sterols and stanols do not affect LDL electrophoretic characteristics in hypercholesterolemic subjects
    Amélie Charest
    Institute on Nutraceuticals and Functional Foods, Laval University, Quebec, Quebec, Canada
    J Nutr 134:592-5. 2004
    ..0 nm). The significant reduction in plasma LDL-C concentrations by sterol and stanol consumption in subjects was not paralleled by any beneficial changes in LDL electrophoretic characteristics...
  46. ncbi request reprint Red yeast rice: a new hypolipidemic drug
    Mélanie Journoud
    School of Human Nutrition, Faculty of Agricultural and Environmental Sciences, McGill University, Montreal, Canada
    Life Sci 74:2675-83. 2004
    ..It is concluded from the present evidence that other types of pigmented rice possess opportunities for development as new functional foods...
  47. ncbi request reprint Very long chain fatty acids (policosanols) and phytosterols affect plasma lipid levels and cholesterol biosynthesis in hamsters
    Yanwen Wang
    School of Dietetics and Human Nutrition, GcGill University, Ste Anne de Bellevue, Quebec, Canada
    Metabolism 54:508-14. 2005
    ..05) in animals fed VLCFA25 and VLCFA50 than those fed control or VLCFA25/LT or VLCFA25/PS. Results suggest that PSs can decrease total and non-HDL-C cholesterol, whereas VLCFA may increase HDL-C in hamsters...
  48. doi request reprint Red algal cellular biomass lowers circulating cholesterol concentrations in Syrian golden hamsters consuming hypercholesterolaemic diets
    Scott V Harding
    Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, 196 Innovation Drive, Winnipeg, MB, Canada R3T 6C5
    Br J Nutr 102:842-7. 2009
    ..There is potential for the use of this biomass as a functional ingredient to aid in the management of blood cholesterol concentrations...
  49. ncbi request reprint Plant sterols are efficacious in lowering plasma LDL and non-HDL cholesterol in hypercholesterolemic type 2 diabetic and nondiabetic persons
    Vivian W Y Lau
    School of Dietetics and Human Nutrition, McGill University, Ste Anne de Bellevue, Canada
    Am J Clin Nutr 81:1351-8. 2005
    ..Differences in plant sterol efficacy between diabetic and nondiabetic persons have not been examined...
  50. ncbi request reprint No changes in serum fat-soluble vitamin and carotenoid concentrations with the intake of plant sterol/stanol esters in the context of a controlled diet
    Mahmoud Raeini-Sarjaz
    School of Dietetics and Human Nutrition, Faculty of Agricultural and Environmental Sciences McGill University, 21, 111 Lakeshore Road, Ste Anne de Bellevue, Quebec, Canada H9X 3V9
    Metabolism 51:652-6. 2002
    ..In conclusion, our results show no effect of consumption of esterified plant sterols or stanols on serum fat-soluble vitamin or carotenoid concentrations compared with a control diet...
  51. pmc Effects of dietary cholesterol and simvastatin on cholesterol synthesis in Smith-Lemli-Opitz syndrome
    Yen Ming Chan
    Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, Manitoba, Canada
    Pediatr Res 65:681-5. 2009
    ..The data suggest that dietary cholesterol supplementation reduces cholesterol synthesis in SLOS and further support the rationale for the combined treatment of SLOS with a cholesterol-enriched diet and simvastatin...
  52. doi request reprint Glycemic responses and sensory characteristics of whole yellow pea flour added to novel functional foods
    Christopher P F Marinangeli
    Richardson Centre for Functional Foods and Nutraceuticals, Univ of Manitoba, 196 Innovation Drive, Winnipeg MB, R3T 2N2, Canada
    J Food Sci 74:S385-9. 2009
    ..02) for smell compared to WWF pasta (3.6 +/- 1). WYPF can be used to produce low-glycemic functional foods possessing sensory attributes that are comparable to identical food products containing WWF...
  53. doi request reprint Sugar cane policosanols do not reduce LDL oxidation in hypercholesterolemic individuals
    Amira N Kassis
    School of Dietetics and Human Nutrition, McGill University, Montreal, QC, Canada
    Lipids 44:391-6. 2009
    ..The findings of the present study suggest that SCP do not significantly affect LDL oxidation. Our results align with results of recent policosanol research questioning the efficacy of these natural extracts as cardio-protective agents...
  54. doi request reprint Hepatic nuclear sterol regulatory binding element protein 2 abundance is decreased and that of ABCG5 increased in male hamsters fed plant sterols
    Scott V Harding
    Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Canada R3T 6C5
    J Nutr 140:1249-54. 2010
    ..In conclusion, high-dose plant sterol feeding of hamsters changes hepatic protein abundance in favor of cholesterol excretion despite lower hepatic cholesterol concentrations and higher cholesterol fractional synthesis...
  55. ncbi request reprint Cholesterol-lowering effect of plant sterols
    Suhad S AbuMweis
    Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, Smartpark, 196 Innovation Drive, Winnipeg, Manitoba, R3T 6C5, Canada
    Curr Atheroscler Rep 10:467-72. 2008
    ..The addition of plant sterols to the diet is suggested by health experts as a safe and effective way to reduce the risk of coronary heart disease...
  56. ncbi request reprint Milk enriched with conjugated linoleic acid fails to alter blood lipids or body composition in moderately overweight, borderline hyperlipidemic individuals
    Sudha Venkatramanan
    Richardson Centre for Functional Foods and Nutraceuticals, 196 Innovation Drive, Smartpark, University of Manitoba, Winnipeg, Manitoba R3T 6C5, Canada
    J Am Coll Nutr 29:152-9. 2010
    ..The effects of dietary CLA on blood lipids and body composition in humans remain controversial...
  57. ncbi request reprint Effects of early cholesterol intake on cholesterol biosynthesis and plasma lipids among infants until 18 months of age
    Théa A Demmers
    School of Dietetics and Human Nutrition, McGill University, 21111 Lakeshore Rd, Montreal, QC, H9X 3V9, Canada
    Pediatrics 115:1594-601. 2005
    ....
  58. ncbi request reprint Fish oil fatty acid esters of phytosterols alter plasma lipids but not red blood cell fragility in hamsters
    Isabelle Demonty
    School of Dietetics and Human Nutrition, McGill University, Sainte Anne de Bellevue, Quebec, Canada H9X 3V9
    Lipids 40:695-702. 2005
    ..The present results show that EPA and DHA esters of plant sterols have a hypocholesterolemic effect in hamsters, and that these new esters of plant sterols exert no detrimental effect on erythrocyte fragility...
  59. ncbi request reprint Combination diet and exercise interventions for the treatment of dyslipidemia: an effective preliminary strategy to lower cholesterol levels?
    Krista A Varady
    School of Dietetics and Human Nutrition, McGill University, Ste Anne de Bellevue, QC, Canada
    J Nutr 135:1829-35. 2005
    ....
  60. ncbi request reprint Plant sterols and endurance training combine to favorably alter plasma lipid profiles in previously sedentary hypercholesterolemic adults after 8 wk
    Krista A Varady
    School of Dietetics and Human Nutrition, Faculty of Agricultural and Environmental Sciences, McGill University, Montreal, and the Veterans Hospital, Sainte Anne de Bellevue, Quebec
    Am J Clin Nutr 80:1159-66. 2004
    ..Plant sterol supplementation was shown to reduce total and LDL-cholesterol concentrations, whereas endurance training was shown to increase HDL-cholesterol concentrations and decrease triacylglycerol concentrations...
  61. ncbi request reprint Role of policosanols in the prevention and treatment of cardiovascular disease
    Krista A Varady
    School of Dietetics and Human Nutrition, McGill University, Ste Anne de Bellevue, Quebec, Canada
    Nutr Rev 61:376-83. 2003
    ..In summary, policosanols are a promising resource in the prevention and therapy of cardiovascular disease (CVD), but these results need to be confirmed in independent laboratories...
  62. ncbi request reprint Lack of effect of sugar cane policosanol on plasma cholesterol in Golden Syrian hamsters
    Amira N Kassis
    School of Dietetics and Human Nutrition, McGill University, 21, 111 Lakeshore Road, Ste Anne de Bellevue, Montreal, Quebec H9X 3V9, Canada
    Atherosclerosis 194:153-8. 2007
    ..The outcome of the present study questions the clinical usefulness of policosanol mixtures as cholesterol-lowering nutraceuticals...
  63. doi request reprint Genetic variation in ABC G5/G8 and NPC1L1 impact cholesterol response to plant sterols in hypercholesterolemic men
    Hai L Zhao
    Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, 196 Innovation Drive, Winnipeg, MB, R3T 6C5, Canada
    Lipids 43:1155-64. 2008
    ..Results suggest that genetic and metabolic biomarkers together may predict inter-individual lipid level responsiveness to PS-intervention, and thus could be useful in devising individualized cholesterol lowering strategies...
  64. ncbi request reprint Comparison of composition and absorption of sugarcane policosanols
    Christopher P F Marinangeli
    School of Dietetics and Human Nutrition, McGill University, Ste Anne de Bellevue, Quebec, H9X 3V9 Canada
    Br J Nutr 97:381-8. 2007
    ..05) than hamsters receiving APC1. If the cholesterol-lowering efficacy of PC mixtures is dependent on their purity and composition, then sugarcane-derived APC products should possess similar therapeutic properties as the OPC supplement...
  65. ncbi request reprint Diacylglycerol: efficacy and mechanism of action of an anti-obesity agent
    Iwona Rudkowska
    School of Dietetics and Human Nutrition, Faculty of Agricultural and Environmental Sciences, McGill University, Montreal, Quebec, Canada
    Obes Res 13:1864-76. 2005
    ..Safety studies show no risks in consuming a diet rich in DAG oil. Overall, consumption of oils with higher amounts of DAG, specifically 1,3-DAG, may be useful in the battle against obesity...
  66. doi request reprint Conjugated linoleic acids: why the discrepancy between animal and human studies?
    Mélanie Plourde
    Research Center on Aging and Departments of Medicine, and Physiology and Biophysics, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Nutr Rev 66:415-21. 2008
    ..The relatively unknown metabolic fate of CLA in humans may also be a contributing factor that helps explain the lack of consistency for CLA efficacy across studies...
  67. ncbi request reprint Alpha-lipoic acid and cardiovascular disease
    Stephanie D Wollin
    School of Dietetics and Human Nutrition, McGill University, Ste Anne de Bellevue, Quebec, Canada
    J Nutr 133:3327-30. 2003
    ..However, collectively the literature increases our understanding of the potential uses for supplementation with ALA and identifies key areas for future research...
  68. doi request reprint Functional food ingredients as adjunctive therapies to pharmacotherapy for treating disorders of metabolic syndrome
    Christopher P F Marinangeli
    The Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, Manitoba, R3T 2N2, Canada
    Ann Med 42:317-33. 2010
    ..Accordingly, new developments in FFN research must be implemented into clinical guidelines with the prospect of improving disease prognoses as accessories to prescription medications...
  69. doi request reprint Diacylglycerol oil reduces body fat but does not alter energy or lipid metabolism in overweight, hypertriglyceridemic women
    Quangeng Yuan
    Richardson Centre for Functional Foods and Nutraceuticals, Faculty of Human Ecology, University of Manitoba, Winnipeg, Manitoba, Canada
    J Nutr 140:1122-6. 2010
    ..We conclude that although DAG oil is not effective in lowing serum lipids over a 4-wk intervention, it may be useful for reducing adiposity...
  70. ncbi request reprint Physiological effects of medium-chain triglycerides: potential agents in the prevention of obesity
    Marie Pierre St-Onge
    School of Dietetics and Human Nutrition, McGill University, Ste Anne de Bellevue, Quebec, Canada, H9X 3V9
    J Nutr 132:329-32. 2002
    ..From the literature reviewed, we conclude that MCT increase energy expenditure, may result in faster satiety and facilitate weight control when included in the diet as a replacement for fats containing LCT...
  71. ncbi request reprint Generic and product-specific health claim processes for functional foods across global jurisdictions
    Stephanie Jew
    School of Dietetics and Human Nutrition, McGill University, Ste Anne de Bellevue, Quebec H9X 3V9, Canada
    J Nutr 138:1228S-36S. 2008
    ..Product-specific claims tended to use human RCT as the main basis for claims, whereas generic claims tended to base their statements on a wider spectrum of literature...
  72. ncbi request reprint Physiological and therapeutic factors affecting cholesterol metabolism: does a reciprocal relationship between cholesterol absorption and synthesis really exist?
    Sylvia Santosa
    School of Dietetics and Human Nutrition, McGill University, Montreal, Quebec, Canada
    Life Sci 80:505-14. 2007
    ..An understanding of this reciprocal relationship between cholesterol absorption and synthesis may allow for the development of more effective interventions for dyslipidemic disorders...
  73. doi request reprint Polymorphisms in ABCG5/G8 transporters linked to hypercholesterolemia and gallstone disease
    Iwona Rudkowska
    School of Dietetics and Human Nutrition, Faculty of Agricultural and Environmental Sciences, McGill University, Ste Anne de Bellevue, Quebec, Canada
    Nutr Rev 66:343-8. 2008
    ..Clearly, the ABCG5 and ABCG8 genes play an important role in cholesterol homeostasis. However, more research is needed to establish how specific polymorphisms of these genes confer to higher risk of these diseases...
  74. ncbi request reprint Effect of weight loss resulting from a combined low-fat diet/exercise regimen on low-density lipoprotein particle size and distribution in obese women
    Krista A Varady
    School of Dietetics and Human Nutrition, McGill University, Montreal, Quebec, Canada, H9X 3V9
    Metabolism 55:1302-7. 2006
    ..In conclusion, these findings suggest that weight loss, resulting from a low-fat diet/exercise program, has only a minimal effect on LDL particle size and distribution...
  75. ncbi request reprint Action of plant sterol intervention on sterol kinetics in hypercholesterolemic men with high versus low basal circulatory plant sterol concentrations
    Hai L Zhao
    Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, Manitoba, Canada
    J Am Coll Nutr 30:155-65. 2011
    ..It is therefore essential to examine campesterol, β-sitosterol, and cholesterol absorption and cholesterol fractional synthesis rate (FSR) following PS consumption in individuals with high versus low basal circulatory PS concentrations...
  76. ncbi request reprint Impact of bedtime snack composition on prevention of nocturnal hypoglycemia in adults with type 1 diabetes undergoing intensive insulin management using lispro insulin before meals: a randomized, placebo-controlled, crossover trial
    Maria Kalergis
    McGill Nutrition Centre, Royal Victoria Hospital, MUHC, McGill University, Montreal, Quebec, Canada
    Diabetes Care 26:9-15. 2003
    ....
  77. ncbi request reprint Measurement of total energy expenditure by the doubly labelled water method in professional soccer players
    Naoyuki Ebine
    Laboratory of Biochemistry of Exercise and Nutrition, Institute of Health and Sport Sciences, University of Tsukuba, Ibaraki, Japan
    J Sports Sci 20:391-7. 2002
    ..Energy intake estimated using dietary records was under-reported, suggesting that its calculation from these data does not predict energy expenditure in soccer players...
  78. ncbi request reprint Effect of n-3 polyunsaturated fatty acids on risk reduction of sudden death
    Peter J H Jones
    School of Dietetics and Human Nutrition, University of McGill, Montreal, QC H9X 3V9, Canada
    Nutr Rev 60:407-9. 2002
    ..The mechanism likely involves an antiarrhythmic effect, further supporting the role of dietary n-3 PUFA in maintenance of human health...
  79. ncbi request reprint Effect of ursodeoxycholic acid on cholesterol absorption and metabolism in humans
    Laura A Woollett
    Division of Pediatric Gastroenterology Hepatology and Nutrition, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Lipid Res 44:935-42. 2003
    ....
  80. ncbi request reprint Health claims on foods in Canada: toward successful implementation
    Peter J H Jones
    School of Dietetics and Human Nutrition, McGill University, 21, 111 Lakeshore Road, Ste Anne de Bellevue, Quebec H9X 3V9
    Can J Public Health 94:260-4. 2003
  81. ncbi request reprint Modulation of apolipoprotein A1 and B, adiponectin, ghrelin, and growth hormone concentrations by plant sterols and exercise in previously sedentary humans
    Melissa Collins
    School of Dietetics and Human Nutrition, McGill University, Ste Anne de Bellevue, Montreal, QC H9X3V9, Canada
    Can J Physiol Pharmacol 85:903-10. 2007
    ..10, p = 0.006) and high-density lipoprotein cholesterol (r = 0.17, p = 0.0003). These findings suggest that plant sterols can increase adiponectin levels, thereby possibly reducing the risk of future coronary heart disease...
  82. ncbi request reprint Plasma concentrations of plant sterols: physiology and relationship with coronary heart disease
    Yen Ming Chan
    School of Dietetics and Human Nutrition, McGill University, 21, 111 Lakeshore Road, Ste Anne de Bellevue, Quebec, Canada H9X 3V9
    Nutr Rev 64:385-402. 2006
    ..Since these factors may act as potential confounders, they must be controlled for before more solid conclusions can be reached...
  83. ncbi request reprint Probiotics and their potential health claims
    Sylvia Santosa
    School of Dietetics and Human Nutrition, McGill University, Ste Anne de Bellevue, Quebec, Canada
    Nutr Rev 64:265-74. 2006
    ..Future studies that use consistent supplementation regimes will allow more definitive conclusions to be drawn on the effects of probiotics on IBS, inflammatory bowel disease, and colon cancer...
  84. ncbi request reprint Effects of different phytosterol analogs on colonic mucosal cell proliferation in hamsters
    Xiaoming Jia
    School of Dietetics and Human Nutrition, McGill University, Macdonald Campus, QC, Canada H9X 3V9
    J Nutr Biochem 17:396-401. 2006
    ..The aim of this study was to investigate the effects of different phytosterols and their analogs on colonic mucosal cell proliferation in hamsters...
  85. ncbi request reprint L-rhamnose and lactulose decrease serum triacylglycerols and their rates of synthesis, but do not affect serum cholesterol concentrations in men
    Janet A Vogt
    Clinical Nutrition and Risk Factor Modification Centre, St Michael s Hospital, Toronto, ON, Canada
    J Nutr 136:2160-6. 2006
    ..Although these data are consistent with inhibition of TGFA synthesis by SCFA, other aspects of the metabolism of these sugars cannot be ruled out as putative agents of their TG-lowering effects...
  86. ncbi request reprint Effects of chenodeoxycholic acid and deoxycholic acid on cholesterol absorption and metabolism in humans
    Yanwen Wang
    Institute for Nutrisciences and Health, National Research Council of Canada, Charlottetown, Prince Edward Island, Canada
    Transl Res 148:37-45. 2006
    ..Results of these 2 studies suggest that the solubilization of cholesterol in the intestinal micelles is not a rate-limiting step for its absorption...
  87. ncbi request reprint Effects of a water-soluble phytostanol ester on plasma cholesterol levels and red blood cell fragility in hamsters
    Naoyuki Ebine
    School of Dietetics and Human Nutrition, Macdonald Campus of McGill University, Quebec, Canada H9X 3V9
    Lipids 40:175-80. 2005
    ..Erythrocyte fragility was unaffected by DAPP or free phytostanols. Results of the current study demonstrate that DAPP lowers cholesterol more efficiently than free stanols, without an adverse effect on erythrocyte fragility in hamsters...
  88. ncbi request reprint Soy protein reduces triglyceride levels and triglyceride fatty acid fractional synthesis rate in hypercholesterolemic subjects
    Yanwen Wang
    School of Dietetics and Human Nutrition, Macdonald Campus of McGill University, Ste Anne de Bellevue, QE, Canada H9X 3V
    Atherosclerosis 173:269-75. 2004
    ..009) but had no significant effect on LDL, HDL cholesterol levels, or FC-FSR. These data demonstrate that dietary protein type modulates circulating TG and cholesterol levels in hypercholesterolemic individuals by distinct mechanisms...
  89. ncbi request reprint Cholic acid supplementation enhances cholesterol absorption in humans
    Laura A Woollett
    Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Ohio, USA
    Gastroenterology 126:724-31. 2004
    ..The role of cholic acid (CA) in cholesterol absorption in humans remains unclear and, thus, was examined in the current study...
  90. ncbi request reprint Limitations of plasma plant sterols as indicators of cholesterol absorption
    Catherine A Vanstone
    Am J Clin Nutr 79:340-1. 2004
  91. ncbi request reprint Longer term effects of early dietary cholesterol level on synthesis and circulating cholesterol concentrations in human infants
    Timothy M Bayley
    School of Dietetics and Human Nutrition, Macdonald Campus of McGill University, Ste Anne de Bellevue, Quebec, Canada
    Metabolism 51:25-33. 2002
    ..These findings support the notion that early dietary cholesterol causes minimal changes in cholesterol metabolism about 6 months after dietary exposure in young infants...
  92. ncbi request reprint Ingestion of phytosterols is not potentially hazardous
    Peter J H Jones
    J Nutr 137:2485; author reply 2486. 2007