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Genomes and Genes | Pauline JohnsonSummaryAffiliation: University of British Columbia Country: Canada Publications
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Publications
CD44 and its role in inflammation and inflammatory diseasesPauline Johnson
Department of Microbiology and Immunology, 2350 Health Sciences Mall, University of British Columbia, Vancouver, B C, V6T 1Z3, Canada
Inflamm Allergy Drug Targets 8:208-20. 2009..Here we describe the contributions of CD44 and hyaluronan to an inflammatory response and discuss the role of CD44 in both promoting and resolving inflammation in various mouse models of inflammatory disease...- Tyrosine phosphorylation in immune cells: direct and indirect effects on toll-like receptor-induced proinflammatory cytokine productionPauline Johnson
Department of Microbiology and Immunology, University of British Columbia, Canada
Crit Rev Immunol 29:347-67. 2009..Finally, we consider how tyrosine phosphorylation signals from other signaling pathways integrate with the TLR signaling pathway to modulate proinflammatory cytokine production... - A role for the cell adhesion molecule CD44 and sulfation in leukocyte-endothelial cell adhesion during an inflammatory response?P Johnson
Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada
Biochem Pharmacol 59:455-65. 2000..Finally, we examined the potential role of sulfation as an inducible means to regulate CD44-mediated leukocyte adhesion and as a more general mechanism to regulate leukocyte-endothelial cell interactions... - CD44 and its Role in Inflammation and Inflammatory DiseasesP Johnson
Department of Microbiology and Immunology, 2350 Health Sciences Mall, University of British Columbia, Vancouver, V6T 1Z3, Canada
Inflamm Allergy Drug Targets 8:208-20. 2009..Here we describe the contributions of CD44 and hyaluronan to an inflammatory response and discuss the role of CD44 in both promoting and resolving inflammation in various mouse models of inflammatory disease... 
Differential use of chondroitin sulfate to regulate hyaluronan binding by receptor CD44 in Inflammatory and Interleukin 4-activated MacrophagesBrian Ruffell
Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
J Biol Chem 286:19179-90. 2011..Thus, inflammatory and anti-inflammatory stimuli differentially regulate the chondroitin sulfation of CD44, which is a dynamic physiological regulator of hyaluronan binding by CD44 in mouse macrophages...- Hyaluronan induces cell death in activated T cells through CD44Brian Ruffell
Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
J Immunol 181:7044-54. 2008..This demonstrates that hyaluronan can induce cell death in activated, high hyaluronan binding T cells via a Fas-independent mechanism... - CD45 down-regulates Lck-mediated CD44 signaling and modulates actin rearrangement in T cellsNelson K Y Wong
Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada
J Immunol 181:7033-43. 2008.... 
CD44 interacts directly with Lck in a zinc-dependent mannerDennis C Lefebvre
Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada
Mol Immunol 47:1882-9. 2010..Taken together, we conclude that CD44 directly associates with Lck in a zinc-inducible manner and this is important for the transmission of CD44-mediated signaling events leading to T cell spreading...- CD45 regulates migration, proliferation, and progression of double negative 1 thymocytesJacqueline C Y Lai
Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
J Immunol 185:2059-70. 2010..CD45(-/-) CD117(-) DN1 cells were also deficient in TCRbeta expression. Thus, CD45 deficiency affects the development and progression of DN1 thymocytes... - Expression of CD45 lacking the catalytic protein tyrosine phosphatase domain modulates Lck phosphorylation and T cell activationYanni Wang
Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
J Biol Chem 280:14318-24. 2005..This finding suggests that, in addition to their established roles in the initiation of TCR signaling, CD45 and Lck may also influence the type of TCR signal generated... - CD44-mediated elongated T cell spreading requires Pyk2 activation by Src family kinases, extracellular calcium, phospholipase C and phosphatidylinositol-3 kinaseNelson K Y Wong
Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada
Cell Signal 23:812-9. 2011..Together this demonstrates that multiple factors are required for CD44-induced Pyk2 activation, which plays a critical role in CD44-mediated elongated T cell spreading... - Subdomain X of the kinase domain of Lck binds CD45 and facilitates dephosphorylationJackie Felberg
Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
J Biol Chem 279:3455-62. 2004..This demonstrates a role for CD45-D2 in binding substrate and identifies the SD10 region in Lck as a novel site involved in substrate recognition... - Regulation of hyaluronan binding by F-actin and colocalization of CD44 and phosphorylated ezrin/radixin/moesin (ERM) proteins in myeloid cellsKelly L Brown
Department of Microbiology and Immunology, University of British Columbia, 300 6174 University Boulevard, Vancouver, B C, Canada, V6T 1Z3
Exp Cell Res 303:400-14. 2005..Taken together, these data suggest that CD44-mediated hyaluronan binding in human myeloid cells is regulated by P-ERM and the actin cytoskeleton... - CD45 regulates TLR-induced proinflammatory cytokine and IFN-beta secretion in dendritic cellsJennifer L Cross
Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada
J Immunol 180:8020-9. 2008..This indicates a new role for CD45 in regulating TLR-induced responses in DCs and implicates CD45 in a wider regulatory role in innate and adaptive immunity... - Differential function of PTPalpha and PTPalpha Y789F in T cells and regulation of PTPalpha phosphorylation at Tyr-789 by CD45Lola Maksumova
Departments of Pediatrics, Microbiology and Immunology, and Pathology and Laboratory Medicine, University of British Columbia and Child and Family Research Institute, Vancouver, British Columbia V6T 1Z3, Canada
J Biol Chem 282:20925-32. 2007..These data demonstrate distinct activities of PTPalpha and PTPalpha-Y789F in T cells and identify CD45 as a regulator of PTPalpha phosphorylation at tyrosine 789 in T cells... - Hyaluronan binding identifies the most proliferative activated and memory T cellsNina Maeshima
Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
Eur J Immunol 41:1108-19. 2011..This study demonstrates that hyaluronan binding is induced upon antigen-induced T-cell activation and occurs on a percentage of the most proliferative activated and memory T cells... - Chondroitin sulfate addition to CD44H negatively regulates hyaluronan bindingBrian Ruffell
Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada V6T 1Z3
Biochem Biophys Res Commun 334:306-12. 2005.... - Expression of N-acetylglucosamine 6-O-sulfotransferases (GlcNAc6STs)-1 and -4 in human monocytes: GlcNAc6ST-1 is implicated in the generation of the 6-sulfo N-acetyllactosamine/Lewis x epitope on CD44 and is induced by TNF-alphaSie Lung Tjew
Department of Microbiology and Immunology, University of British Columbia, 300-6174 University Boulevard, Vancouver, British Columbia, Canada V6T 1Z3
Glycobiology 15:7C-13C. 2005..This demonstrates the induction of GlcNAc6STs in human monocytes in response to TNF-alpha and implicates GlcNAc6ST-1 in the generation of the 6-sulfo LacNAc/Lewis x epitope on CD44... - Y-box binding protein-1 induces the expression of CD44 and CD49f leading to enhanced self-renewal, mammosphere growth, and drug resistanceKaren To
Experimental Medicine Program, University of British Columbia, Canada
Cancer Res 70:2840-51. 2010..Importantly, targeting YB-1 sensitized the CD44(High)/CD24(Low) cells to paclitaxel. In conclusion, YB-1 promotes cancer cell growth and drug resistance through its induction of CD44 and CD49f... - The Suv39H1 methyltransferase inhibitor chaetocin causes induction of integrated HIV-1 without producing a T cell responseWendy Bernhard
Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, Canada
FEBS Lett 585:3549-54. 2011..These results indicate that chaetocin may provide a therapy to purge cells of latent HIV-1, possibly in combination with other chromatin remodeling drugs... - H2-M3-restricted T cells participate in the priming of antigen-specific CD4+ T cellsMichael T Chow
Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada
J Immunol 177:5098-104. 2006..These results reveal a novel function for H2-M3- and Qa-1-restricted T cells; provision of help to CD4+ Th cells during the primary response... - TNF-alpha increases the carbohydrate sulfation of CD44: induction of 6-sulfo N-acetyl lactosamine on N- and O-linked glycansMarc Delcommenne
Department of Microbiology and Immunology, 6174 University Boulevard, University of British Columbia, Vancouver, British Columbia, V6T 1Z3 Canada
Glycobiology 12:613-22. 2002..In addition, it demonstrates that TNF-alpha can induce the expression of 6-sulfo N-acetyl glucosamine on both N- and O-linked glycans of CD44 in myeloid cells... - The noncatalytic domains of Lck regulate its dephosphorylation by CD45Dennis C Lefebvre
Department of Microbiology and Immunology, University of British Columbia, 300 6174 University Boulevard, Vancouver, BC, Canada V6T 1Z3
Biochim Biophys Acta 1650:40-9. 2003..This demonstrates that the noncatalytic domains of Lck regulate the dephosphorylation of both Tyr-394 and Tyr-505 by CD45...